INVITATION XIXth annual symposium of the Dutch Thyroid Research Foundation The Dutch Thyroid Research Foundation (formerly known as the Dutch Thyroid Club) cordially invites you to the 19th edition of its annual symposium, which will take place on June 12 2015 at the Trippenhuis in Amsterdam. International and Dutch experts will highlight important recent developments in fundamental and clinical thyroidology. In addition, a number of young investigators have been selected for short oral presentations. The symposium will start with a clinical session on thyroid cancer with Dr. Kate Newbold (London) as an international expert. She will discuss the use of tyrosine kinase inhibitors in thyroid cancer. This session is followed by a basic session focussing on local thyroid hormone metabolism in muscle. Dr. Monica Dentice (Naples) will present her recent findings on the role of deiodinating enzymes in muscle regeneration. The next basic session is about the consequences of mutations in the α-isoform of the thyroid hormone receptor (TRα) with Prof. Jens Mittag (Lubeck) as a leading expert. He will present the effects of a dominant negative mutation on metabolism in a mouse model. The focus will then shift to clinical thyroidology with Prof. Laszlo Hegedus addressing the association of hypo- and hyperthyroidism with morbidity, mortality, early retirement and income. We look forward to an exciting meeting and hope to see you in Amsterdam! The Dutch Thyroid Research Foundation 9:30 Welcome and registration 10:00 Introduction Thyroid cancer 10.10: 10.20: 10.30: 10.40: Recent developments in thyroid cancer Thera Links (UMCG, Groningen) Differentiated thyroid carcinoma in children: a long-term follow-up study Marielle Klein Hesselink (UMCG, Groningen) Role of autophagy in dedifferentiation and RAI therapy resistance in thyroid cancer Theo Plantinga (UMCN, Nijmegen) TKI in thyroid cancer : patient selection and effects Kate Newbold (Royal Marsden Hospital, London, UK) Plenary discussion 11.10: Thyroid hormone action and metabolism: 11.30: 11.40: 11.50: 12.20: 12:45: 13.45: 13.55: 14.05: 14.15: 14.45: TR and the HPT-axis Marcel Meima (Erasmus MC, Rotterdam) The diverse phenotype of patients with mutations in TR Anja van Gucht (Erasmus MC, Rotterdam) The role of TR in metabolism Jens Mittag (University Lubeck, Germany) Plenary discussion Lunch Muscle thyroid hormone metabolism Anita Boelen (AMC, Amsterdam) Type 3 deiodinase in the heart tba (VUMC, Amsterdam) Deiodinases in muscle during illness Flavia Bloise (AMC, Amsterdam) Deodinases in muscle regeneration Monica Dentice (Naples, Italy) Plenary discussion 15:15 Tea Thyroid clinical: 15.45: 15.55: 16.05: 16.35: 17:00 Recent developments in clinical thyroidology Marco Medici (Erasmus MC, Rotterdam) Subclinical thyroid dysfunction and neurological disease Layal Chaker (Erasmus MC, Rotterdam) The association of hypo- and hyperthyroidism with morbidity, mortality, early retirement and income Laszlo Hegedus (Odense university Hospital, Denmark) Plenary discussion Drinks and farewell INSCHRIJVING Locatie: Het Trippenhuis (KNAW Gebouw) Kloveniersburgwal 29 1011 JV Amsterdam Organisatie: Stichting Schildklieronderzoek Nederland Bestuur: dr. W.S. Simonides, dr. A. Boelen, dr. R.P. Peeters, prof. dr. T.P. Links, prof. dr. J.W.A. Smit Inschrijven: U kunt zich inschrijven door een e-mail te sturen t.a.v. Anita Boelen: secr.endo.metab@amc.nl Kosten (inclusief lunch en borrel): Studenten, AIO’s en fellows: € 25,Overige deelnemers: € 50,Het bedrag graag overmaken voor 12 juni op rekening NL02 ABNA 0469862025 t.n.v. Stichting Schildklieronderzoek Nederland, Rotterdam Accreditatie: Het symposium wordt geaccrediteerd door de Nederlandse Internisten Vereniging (NIV)