Pre Test !!!!!!
How many classes of HIV meds are
currently available?
20%
3%
3%
5
5.
4
4.
30%
3
3.
43%
2
2.
1
2
3
4
5
1
1.
A side effect with Reyataz
(atazanavir) which is reversible
when discontinued is?
1. Discoloration of
38%
the fingernail and
31%
toe nails
ai
lu
re
ve
rF
Li
Fa
ey
id
n
K
yp
H
ilu
re
bi
n.
..
er
bi
lir
u
io
n
...
7%
ol
or
at
4.
is
c
3.
Hyperbilirubinemia
Kidney Failure
Liver Failure
D
2.
24%
HIV stands for:
0%
N
on
e
of
at
iti
s
th
e
In
ab
...
je
...
...
ep
H
Im
m
un
od
e
n.
..
Is
la
um
an
H
4.
3%
0%
ia
n
3.
97%
aw
ai
2.
Hawaiian Island
Visitors
Human
Immunodeficiency
Virus
Hepatitis Injection
Vaccine
None of the above
H
1.
The first three steps involved in HIV
cell entry include all of the following
except:
22%
C
ore
c
ng
ep
A
to
r
tta
bi
nd
i
ch
m
en
ra
tio
n
t
19%
te
g
4.
26%
In
3.
33%
si
on
2.
Fusion
Integration
Attachment
Co-receptor
binding
Fu
1.
All the following are combination
formulations except for?
10%
r
iv
i
Tr
iz
m
zi
co
Ep
om
bi
vi
r
3%
C
4.
39%
r
3.
48%
iv
i
2.
Epivir
Combivir
Epzicom
Trizivir
Ep
1.
Like Hepatitis C, HIV is…
of
e
on
N
cu
ra
b
le
th
e
ab
...
vi
ru
...
v.
..
oo
d
bl
A
A
s
4%
0%
bo
rn
e
vi
r ..
.
4%
le
s
4.
rm
3.
93%
ha
2.
A harmless virus
A bloodborne
virus
A curable virus
None of the above
A
1.
What HIV med causes Vivid
Dreams?
1. Selzentry
(Maraviroc)
2. Sustiva
(Efavirenz)
3. Lexiva
(Fosamprenavir)
4. None of the above
68%
23%
6%
ab
...
..
th
e
m
p.
N
on
e
of
(F
os
a
xi
va
Le
st
iv
a
Su
Se
lz
e
nt
ry
(M
(E
fa
v
ar
..
i..
.
.
3%
Living or working with a person who is infected
with HIV can cause someone to get HIV
94%
Tr
ue
6%
ls
e
2.
False
True
Fa
1.
What must one be careful of when
taking Ziagen (abacavir)?
13%
3%
yp
H
R
un
er
se
ny
ns
i
tiv
i
no
s
gh
e
...
0%
ou
C
4.
e
3.
83%
cn
2.
Acne
Cough
Runny nose
Hypersensitivity
reaction
A
1.
The most common side effect found
with the “D” drugs is?
7%
es
eu
...
3%
ra
l
rip
he
Pe
ea
H
N
da
ch
se
a
au
N
4.
30%
rh
ea
3.
60%
ia
r
2.
Diarrhea
Nausea
Headaches
Peripheral
Neuropathy
D
1.
Consistent and correct condom use can
prevent HIV
97%
ls
e
3%
Fa
2.
True
False
Tr
ue
1.
HIV can be transmitted by:
N
on
e
of
ab
...
th
e
ab
o.
..
0%
ft
he
ll
o
lF
lu
id
s
0%
A
gi
na
Se
m
en
0%
Va
d
0%
lo
o
B
6.
0%
...
5.
rty
4.
di
3.
100%
ar
in
g
2.
Sharing dirty
needles
Blood
Semen
Vaginal Fluids
All of the above
None of the above
Sh
1.
Before beginning Selzentry (maraviroc) what
type of lab test must be performed?
H
ct
&
LF
T
7%
hi
le
Hg
b
7%
Tr
op
7%
w
/D
iff
4.
C
3.
80%
B
2.
CBC w/ Diff
Hct & Hgb
Trophile
LFT
C
1.
The only HIV medication currently
on the market which is injected is?
10%
om
bi
vi
C
C
rix
iv
a
on
ze
r
0%
n
0%
Fu
4.
ir
3.
90%
et
ro
v
2.
Retrovir
Fuzeon
Crixivan
Combivir
R
1.
One of the body fluids that can transmit
HIV is:
9%
rin
e
B
re
a
st
U
a
m
ilk
3%
0%
liv
4.
Sa
3.
88%
ar
s
2.
Tears
Saliva
Urine
Breast milk
Te
1.
All of the following agents are
Protease Inhibitors except?
15%
...
(a
ag
en
Zi
Vi
ra
c
ep
t
ba
c
(n
e
av
lf.
.
am
p.
..
(fo
s
..
xi
va
Le
.
11%
(d
ar
u.
4.
26%
ta
3.
48%
is
2.
Prezista
(darunavir)
Lexiva
(fosamprenavir)
Viracept
(nelfinavir)
Ziagen (abacavir)
Pr
ez
1.
Trizivir, although is a 3 med combo
it should not be used alone
because….
23%
th
e
ts
u.
e
on
N
It
do
e
s
of
no
to
o
e
ar
er
e
Th
ab
...
..
...
...
7%
ex
pe
4.
33%
to
o
3.
37%
is
2.
It is too expensive
There are too many
side effects
It does not sustain
good results as triple
nuc therapy
None of the above
It
1.
The first medication used in HIV
was?
(Z
id
o.
ir
et
ro
v
R
Su
e
vi
ra
s
In
st
iv
a
(S
aq
(E
fa
v
i..
.
u.
..
...
(In
di
3%
..
3%
0%
n
4.
iv
a
3.
94%
rix
2.
Crixivan (Indinavir)
Invirase (Saquinavir)
Sustiva (Efavirenz)
Retrovir
(Zidovudine)
C
1.
3%
3%
4
5
3
2
1
What is the least number of HIV
meds that can be used to treat
HIV?
1. 1
41%
2. 2
3. 3
31%
4. 4
21%
5. 5
What HIV med is used as a
booster?
21%
Vi
.
ra
m
un
e
(N
ev
i..
...
ito
na
or
vi
r(
R
at
az
ey
R
N
(A
ta
z
a.
..
el
f..
.
6%
(N
4.
30%
ep
t
3.
42%
ra
c
2.
Viracept
(Nelfinavir)
Reyataz
(Atazanavir)
Norvir (Ritonavir)
Viramune
(Nevirapine)
Vi
1.
The newest HIV medication combined into one
pill and taken once a day by two different
manufacturers is?
37%
17%
m
zi
co
Ep
A
om
bi
vi
tr
ip
r
la
10%
C
4.
r
3.
37%
iv
i
2.
Trizivir
Combivir
Atripla
Epzicom
Tr
iz
1.
HIV Medications 101
Fred Cruz, R.Ph.
Pharmacist-In-Charge
CarePlus CVS/pharmacy
My Personal Story
TEST !!!!!
What is Fred’s male dog’s name?
7%
7%
ud
R
le
s
er
cu
H
y
0%
uz
4.
Ze
3.
86%
or
2.
Thor
Zeuz
Hercules
Rudy
Th
1.
What is Fred’s female dogs name?
9%
6%
ab
...
na
th
e
th
e
of
A
ro
di
te
0%
ph
e
on
N
4.
A
3.
86%
na
2.
Xena
Aphrodite
Athena
None of the above
Xe
1.
What is Fred’s partners occupation?
9%
3%
to
r
oc
of
fic
e
lic
Po
D
ct
er
0%
ite
rc
h
A
4.
is
t
3.
88%
ar
m
ac
2.
Pharmacist
Architect
Police officer
Doctor
Ph
1.
How many pictures did it take to
get the family picture of the dogs?
34%
5
6%
12
3%
0
4.
10
3.
56%
75
2.
50
75
100
125
50
1.
What made Fred interested in
working with HIV?
...
ab
A
ll
o
ft
he
ha
ha
s
Fr
ed
is
fri
e
nd
d
a
m
...
H
o.
..
0%
p.
..
0%
at
io
n
4.
15%
m
ed
ic
3.
85%
IV
2.
HIV medications are
always changing
His friend a pharmacist
had a brother who died
of HIV
Fred has had many
friends die of HIV
All of the above
H
1.
CarePlus Pharmacy Team
HIV Myths
HIV stands for:
1.
2.
3.
4.
Hawaiian Island
Visitors
Human
Immunodeficiency
Virus
Hepatitis Injection
Vaccine
None of the above
Living or working with a person who is infected
with HIV can cause someone to get HIV
1.
2.
False
True
Like Hepatitis C, HIV is…
1.
2.
3.
4.
A harmless virus
A bloodborne
virus
A curable virus
None of the above
Consistent and correct condom use can
prevent HIV
1.
2.
True
False
HIV can be transmitted by:
1.
2.
3.
4.
5.
6.
Sharing dirty
needles
Blood
Semen
Vaginal Fluids
All of the above
None of the above
One of the body fluids that can transmit
HIV is:
1.
2.
3.
4.
Tears
Saliva
Urine
Breast milk
HIV Life Cycle
Videos
HIV: Antiretroviral Therapy
Nucleoside RTI
Entry Inhibitors
Integrase
Inhibitors
Nucleus
HIV
HIV
RNA
Non-Nucleoside RTI
HIV
DNA
Host Cell
Protease Inhibitors
Classes of HIV Meds





Protease Inhibitors (PI’s)
Nucleoside Reverse Transciptase
Inhibitors (NRTI’s)
Non-Nucleoside Reverse Transciptase
Inhibitors (NNRTI’s)
Entry Inhibitors
Integrase Inhibitors
Classes of HIV meds in the pipeline



Maturation Inhibitors
Cellular Inhibitors
Immune Based Therapies
Approved Antiretrovirals
Combivir Ziagen
Hivid
Retrovir
Videx
Epivir
Zerit
Viread
Emtriva
Sustiva
Viramune
Trizivir
Rescriptor
’87 ’88 ’89 ’90 ’91 ’92 ’93 ’94 ’95 ’96 ’97 ’98 ’99 ’00 ’01 ’02 ’03
NRTI
NNRTI
PI
FI
Invirase
Viracept
Kaletra
Fortovase
Norvir
Crixivan
Reyataz
Lexiva
Agenerase
FUZEON
Retrovir, Epivir, Combivir, Ziagen, Agenerase, Lexiva and Trizivir are trademarks of GlaxoSmithKline. Videx, Zerit, Sustiva and Reyataz are
trademarks of Bristol-Myers Squibb. Norvir and Kaletra are registered trademarks of Abbott. Crixivan is registered trademark of Merck.
Viramune is registered trademark of Boehringer Ingelheim. Viracept and Rescriptor are registered trademarks of Agouron. Viread and
Emtriva are trademarks of Gilead. Hivid, Invirase, Fortovase and FUZEON are registered trademarks of Roche Laboratories.
HAART = High Active
Anti-Retroviral Therapy
NRTI’s (Nucleoside Reverse
Transciptase Inhibitors)











Combivir (zidovudine + lamivudine, AZT + 3TC)
Emtriva (emtricitabine, FTC)
Epivir (lamivudine, 3TC)
Epzicom (abacavir + lamivudine, ABC + 3TC)
Retrovir (zidovudine, AZT, ZDV)
Trizivir (abacavir + zidovudine + lamivudine, ABC + AZT +
3TC)
Truvada (tenofovir DF + emtricitabine, TDF + FTC)
Videx & Videx EC (didanosine, ddI)
Viread (tenofovir disoproxil fumarate, TDF)
Zerit (stavudine, d4T)
Ziagen (abacavir, ABC)
NRTI’s in the Pipeline




Racivir (RCV)
Amdoxovir (AMDX, DAPD)
Apricitabine (SPD754, AVX754)
Elvucitabine (ACH-126,443, Beta-L-Fd4C)
NNRTI’s (Non-Nucleoside Reverse
Transciptase Inhibitors)




Intelence (etravirine, TMC-125)
Rescriptor (delavirdine, DLV)
Sustiva (efavirenz, EFV)
Viramune (nevirapine, NVP)
NNRTI’s in the Pipeline

Rilpivirine (TMC-
PI’s (Protease Inhibitors)










Agenerase (amprenavir, APV)
Aptivus (tipranavir, TPV)
Crixivan (indinavir, IDV)
Invirase (saquinavir, SQV)
Kaletra (lopinavir/ritonavir, LPV/r)
Lexiva (fosamprenavir, FPV)
Norvir (ritonavir, RTV)
Prezista (darunavir, DRV)
Reyataz (atazanavir, ATV)
Viracept (nelfinavir)
Entry Inhibitors


Fuzeon (enfuvirtide, ENF, T-20)
Selzentry (maraviroc, UK-427,857)
Entry Inhibitors in the Pipeline



Vicriviroc (SCH-417690, SCH-D)
PRO 140
TNX-355
Integrase Inhibitors

Isentress (raltegravir, MK-0518)
Integrase Inhibitors in the Pipeline

Elvitegravir (GS-9137)
HIV Treatment: Then and
Now
‡
????????’s
DHS/HIV/PP
Post Test HIV Meds 101
The first three steps involved in HIV
cell entry include all of the following
except:
26%
...
7%
bi
to
r
ep
ore
c
C
A
tta
ch
m
en
ra
tio
n
t
7%
te
g
4.
In
3.
59%
si
on
2.
Fusion
Integration
Attachment
Co-receptor
binding
Fu
1.
The first medication used in HIV
was?
R
..
et
ro
v
ir
(Z
id
o.
i..
.
(E
fa
v
Su
e
vi
ra
s
In
st
iv
a
(S
aq
(In
di
3%
0%
u.
..
...
3%
n
4.
iv
a
3.
94%
rix
2.
Crixivan (Indinavir)
Invirase (Saquinavir)
Sustiva (Efavirenz)
Retrovir
(Zidovudine)
C
1.
How many classes of HIV meds are
currently available?
0%
3%
6%
0%
5
5.
4
4.
3
3.
91%
2
2.
1
2
3
4
5
1
1.
What is the least number of HIV
meds that can be used to treat
HIV?
1. 1
50%
2. 2
36%
3. 3
4. 4
5. 5
0%
0%
4
5
3
2
1
14%
What HIV med causes Vivid
Dreams?
1. Selzentry
(Maraviroc)
2. Sustiva
(Efavirenz)
3. Lexiva
(Fosamprenavir)
4. None of the above
94%
0%
ab
...
..
th
e
m
p.
of
e
on
N
xi
va
Le
st
iv
a
Su
(F
os
a
(E
fa
v
ar
..
(M
nt
ry
lz
e
Se
3%
i..
.
.
3%
What HIV med is used as a
booster?
Vi
.
ra
m
un
e
(N
ev
i..
...
ito
na
or
vi
r(
R
at
az
ey
R
N
(A
ta
z
a.
..
el
f..
.
4%
(N
4.
21%
18%
ep
t
3.
57%
ra
c
2.
Viracept
(Nelfinavir)
Reyataz
(Atazanavir)
Norvir (Ritonavir)
Viramune
(Nevirapine)
Vi
1.
All of the following agents are
Protease Inhibitors except?
...
.
av
lf.
.
ba
c
(n
e
Zi
ag
en
(a
ep
t
ra
c
Vi
(fo
s
..
xi
va
Le
4%
am
p.
..
4%
(d
ar
u.
4.
13%
ta
3.
79%
is
2.
Prezista
(darunavir)
Lexiva
(fosamprenavir)
Viracept
(nelfinavir)
Ziagen (abacavir)
Pr
ez
1.
What must one be careful of when
taking Ziagen (abacavir)?
...
0%
tiv
i
yp
R
un
er
se
ny
ns
i
ou
no
s
gh
e
0%
H
3%
C
4.
e
3.
97%
cn
2.
Acne
Cough
Runny nose
Hypersensitivity
reaction
A
1.
The newest HIV medication combined into one
pill and taken once a day by two different
manufacturers is?
26%
17%
m
zi
co
Ep
A
om
bi
vi
tr
ip
r
la
9%
C
4.
r
3.
48%
iv
i
2.
Trizivir
Combivir
Atripla
Epzicom
Tr
iz
1.
Trizivir, although is a 3 med combo
it should not be used alone
because….
15%
th
e
ts
u.
e
on
N
It
do
e
s
of
no
to
o
e
ar
er
e
Th
ab
...
..
...
...
4%
ex
pe
4.
27%
to
o
3.
54%
is
2.
It is too expensive
There are too many
side effects
It does not sustain
good results as triple
nuc therapy
None of the above
It
1.
The most common side effect found
with the “D” drugs is?
48%
eu
...
0%
N
ra
l
rip
he
Pe
H
ea
au
da
ch
se
a
es
0%
N
4.
rh
ea
3.
52%
ia
r
2.
Diarrhea
Nausea
Headaches
Peripheral
Neuropathy
D
1.
Before beginning Selzentry (maraviroc) what
type of lab test must be performed?
T
LF
Tr
op
Hg
b
&
ct
H
hi
le
8%
4%
w
/D
iff
4.
32%
C
3.
56%
B
2.
CBC w/ Diff
Hct & Hgb
Trophile
LFT
C
1.
A side effect with Reyataz
(atazanavir) which is reversible
when discontinued is?
1. Discoloration of
92%
the fingernail and
toe nails
ai
lu
re
0%
ve
rF
Li
Fa
ey
id
n
K
yp
H
ilu
re
bi
n.
..
0%
er
bi
lir
u
io
n
...
8%
ol
or
at
4.
is
c
3.
Hyperbilirubinemia
Kidney Failure
Liver Failure
D
2.
The only HIV medication currently
on the market which is injected is?
om
bi
vi
C
C
rix
iv
a
on
ze
0%
r
0%
n
0%
Fu
4.
ir
3.
100%
et
ro
v
2.
Retrovir
Fuzeon
Crixivan
Combivir
R
1.
All the following are combination
formulations except for?
32%
iv
i
Tr
iz
m
zi
co
Ep
om
bi
vi
r
0%
r
0%
C
4.
r
3.
68%
iv
i
2.
Epivir
Combivir
Epzicom
Trizivir
Ep
1.
Helpful Basic Websites:


www.aidsmeds.com
www.thebody.com