BioGinkgo 27/7
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A 100 Yr. Old Bonsai Ginkgo Tree
Proprietary
extract of ginkgo
leaves
Addresses #2
concern among
aging baby
boomers
 Loss of
memory
1
Ginkgo biloba L. plant: History
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Oldest living plant species, nick named “living
fossil”. In China, it is called “thousand-year-old
tree”
Described in the ancient Chinese pharmacopoeiaShen nown Ben Cao
Since 1960s, Ginkgo biloba extract is the most
widely used herb in Europe
2
Ginkgo biloba L. leaf: History,
cont’d
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Pharmanex scientific advisor, Prof. Koji
Nakanishi, Columbia University:
Discovered a class of unique
ginkgolides in ginkgo plant
Ginkgolides can increase blood flow by
blocking PAF, a substance that causes
platelet clumping
3
BioGinkgo 27/7: Uniqueness
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
Pharmanex extraction process enriches
for ginkgolides
Only Ginkgo extract that provides for
adequate and persistent amounts of
ginkgolides in the blood
4
Blood concentration of ginkolides after
oral intake of BioGinkgo 27/7 or Ginkoba
Ginkgolide levels (µg/ml)
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BioGinkgo 27/7
Ginkoba
10
8
6
4
2
0
30 minutes
Published in Planta Medica
12 hours
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BioGinkgo 27/7 - Attributes
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Unique formulation of enriched for
levels of ginkgolides
Improved bioavailability compared to
competitors
Undesirable Ginkgolic acids removed
One of the few companies to
manufacture its own ginkgo product
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Bioginkgo 27/7 process scheme
Selected leaves
1. crushed
2. aq. Alcohol extract
3. precipitation
QA/QC
4. chromatography
5. remove Ginkgolic acids
6. drying
Flavone-lactone mixture
Finished bulk preparation
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Chemical fingerprint of
ginkgolide terpene lactones
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Ginkgo biloba Extract: Cerebral
Insufficiency
Taillander et al. Presse Med. 1986 15 1583-1587
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12-month placebo controlled trial of 210 elderly patients
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Ave. age 82 years
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End points: Symptoms scale including dizziness, tinnitus, headaches,
lack of energy, and difficulties in memory and concentration at 3, 6, 9,
and 12 months
Treatment
Placebo
Ginkgo
Time of assessment
3
6
9
12 months
4%
4%
8%
8%
10% 15% 15% 17%
9
JAMA clinical study
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A Placebo-Controlled, Double-blind,
Randomized Trial
A 52-week multi-center study
Patients: Outpatients with Alzheimer
disease or multi-infarct dementia,
without other significant medical
conditions.
10
JAMA clinical study: Study
Design
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Complete outcome evaluation at 12, 26,
and 52 weeks.
Primary Outcome Measures.
Alzheimer's Disease Assessment
Scale-Cognitive subscale (ADAS-Cog),
Geriatric Evaluation by Relative's
Rating Instrument (GERRI), and Clinical
Global Impression of Change (CGIC).
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JAMA clinical study:
Conclusions
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Ginkgo group score better than placebo in ADAS-Cog
and GERRI score
No difference in the Clinical Global Assessment Index
Ginkgo was safe
Appears capable of stabilizing and improving the
cognitive performance and the social functioning of
patients for 6 months to 1 year.
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BioGinkgo 27/7: summary
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BioGinkgo enhances blood circulation
to brain, arms, legs
Mechanism of action believed to be
related to flavonoids and ginkgolides
BioGinkgo is recommended to be taken
one tablet twice a day
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Introducing…Bio St. John’s
Standardized St. John’s wort to 0.3% hypericin
(Hypericum perforatum)
PLUS
CordyMax Cs-4 [Patent Pending]
(Cordyceps sinensis)
Each capsule of Bio St John’s contains 375 mg of CordyMax
and 225 mg St John’s wort extract.
The daily recommended dosage is two capsules twice a day.
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Bio St. John’s : Claims
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Stabilizes mood and promotes a
positive outlook
Provides vitality and stamina
Reduces fatigue without stimulants
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Bio St. John’s: Benefits
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Bio St. John’s is not a substitute for
prescription anti-depressant drugs
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St. John’s Wort: Brit. Medical
Journal Study
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Meta-Analysis (BMJ, 1996)
 23
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randomized trials with 1,757 patients
% patients respond to treatment
 SJW
(55.1%) vs Placebo (22.3%)
 SJW (63.9%) vs Antidepressant (58.5%)
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Test on mild/moderate depression
 major
depression or manic depressive
disorder not tested
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Putative mechanisms of action
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Monoamine oxidase inhibition
Selective serotonin-reuptake inhibition
Inhibition of catechol Omethyltransferase
GABA and neurokinin receptors
Overall outcome: Effect on neurotransmitters function
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St. John’s wort : Safety/Possible
side effects
Most common adverse effects are:
 GI symptoms
 Tiredness/sedation
 Dizziness/confusion
 Photosensitivity, but this appears to
occur rarely
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Efficacy with age
Age
Before St.John’s wort
After St.John’s wort
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Bio St. John’s
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A combination of St. John’s wort and
CordyMax
The recommended dose for Bio St
John’s is 4 capsules daily
It is not a replacement for prescription
anti-depressants
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