Recognizing and Preventing Overdose and Administering Naloxone www.OverdoseFreePA.pitt.edu Substance Use Disorder Treatment Professional Curricula Core Component 2 © 2014, Overdose Prevention Coalition The OverdoseFreePA website is brought to you by the Overdose Prevention Coalition, a collaborative between: The Pennsylvania Department of Drug and Alcohol Programs (DDAP) The Single County Authorities (SCAs) of: Allegheny County Blair County Bucks County Butler County Dauphin County Delaware County Westmoreland County The Allegheny County Medical Examiner’s Office The Program Evaluation Research Unit, University of Pittsburgh School of Pharmacy The project is supported by a generous grant from the Pennsylvania Commission on Crime and Delinquency. SAMHSA National Survey Past Month Nonmedical Use of Types of Psychotherapeutic Drugs among Persons Aged 12 or Older: 2002-2012 Substance Abuse and Mental Health Services Administration (SAMHSA), 2013 SAMHSA National Survey Source Where Pain Relievers Were Obtained for Most Recent Nonmedical Use among Past Year Users Aged 12 or Older: 2011-2012 SAMHSA, 2013 Overview of Substance and Drug Use Past-Year Initiates for Specific Illicit Drugs Among Persons Age 12 or Older, 2008 SAMHSA, 2009 Overdose • An overdose means having too much of a drug or alcohol, or a mix of drugs and/or alcohol for your body to safely handle. • Overdose can result in permanent brain damage, permanent organ damage or death. • Overdose symptoms can look different depending what kinds of drugs were used. DDAP, 2014; Centers for Disease Control and Prevention (CDC), 2012 Overdose (cont’d) • Drug overdose was the leading cause of injury death in the U.S. in 2010. • Among people 25 to 64 years old, drug overdose caused more deaths than motor vehicle traffic crashes in 2010. CDC, 2012 Overdose Deaths in Pennsylvania DRUG OVERDOSE DEATHS IN PENNSYLVANIA Number of PA Rate per Deaths Population 1,000 Year 2011 1,909 12,742,886 15.4 2010 1,550 12,702,379 12.5 2008 1,522 12,448,279 12.6 2006 1,344 12,440,621 11.2 2004 1,278 12,406,292 10.6 2002 895 12,335,091 7.5 2000 896 12,281,054 7.4 1998 628 12,001,451 5.4 1996 630 12,056,112 5.4 1994 596 12,052,410 5.1 1992 449 11,995,405 3.8 1990 333 11,881,643 2.7 Based on Pennsylvania Department of Health data, overdose deaths have been on the rise over the last two decades, with an increase in the rate of death from 2.7 to 15.4 per thousand Pennsylvanians. DDAP, 2014 It’s Good to Know … Different drugs have different overdose symptoms. International Overdose Awareness Day (IOAD), 2014 Symptoms of Overdose • Depending on the drug(s) involved, an overdose victim can exhibit different symptoms. • It’s important to be able to recognize the symptoms of overdose. – Time is a factor. – Prescription pills are involved in about 60% of overdose deaths. IOAD, 2014; Jones, 2013 Signs of Alcohol Overdose: • Confusion • Difficulty remaining conscious • Slow breathing or gaps in breathing • Clammy skin • Vomiting • Seizures • Slow heart rate • Dulled responses • Extremely low body temperature DDAP, 2014 Signs of Amphetamine/Other Stimulant (“Speed”) Overdose: • Amphetamine-induced psychosis – (paranoia, hallucinations and/or delusions) • Overheating • Dehydration • High blood pressure • Seizures DDAP, 2014 Signs of Opioid (Heroin, Narcotic Pain Medication, Etc.) or Depressant (Xanax, Valium, Etc.) Overdose: • Slow and shallow breathing • Very sleepy and unable to talk • Unconscious • Blue lips or fingertips • Snoring or gurgling sounds DDAP, 2014 Overdose Prevention • Recognize the symptoms of an overdose. • Call 911 immediately! • Act quickly to administer rescue breathing. • Administer Naloxone (Narcan®) if it’s available. DDAP, 2014 Strategies for Reducing Overdose Deaths • Prescription Monitoring Programs: • Reduce Diversion, not demonstrated to reduce overdose. • Concern about increase in heroin use. • Methadone and Suboxone treatment: Very effective • Abstinence-based drug treatment: • Risk of overdose increases when relapse occurs. Bell, 2012 Strategies for Reducing Overdose Deaths (cont’d) – Community Based Education: Risk Factors, Identification of Symptoms, Effective Response, including Rescue Breathing, Calling 911 and Naloxone Administration – Naloxone Prescription Programs – Physician Prescribing when prescribing opioids for pain Bell, 2012 About Naloxone • Naloxone reverses opioid-related sedation and respiratory depression = pure opioid antagonist – Not psychoactive, no abuse potential – May cause withdrawal symptoms • May be administered IM, IV, SC, IN • Acts within 2 to 8 minutes • Lasts 30 to 90 minutes, overdose may return • May be repeated • Narcan® = naloxone • naloxone ≠ Suboxone ≠ naltrexone Walley, 2013 Intranasal Administration Mucosal Atomization Device (MAD) Pro • 1st line for some local EMS • RCTs: slower onset of action but milder withdrawal • Acceptable to non-users • No needle stick risk • No disposal concerns Prefilled naloxone ampule Luer-lock syringe Con • Not FDA approved • No large RCT • Assembly required, subject to breakage • High cost: – $40-50+ per kit Walley, 2013 Intranasal Administration (cont’d) Walley, 2013 When is Naloxone Prescribed? 1. Patient release after emergency medical care involving opioid OD/intoxication 2. Suspected history of illicit or nonmedical opioid use 3. High-dose opioid prescription (> 50 mg of morphine equivalence/day) 4. Any methadone prescription to opioid naïve patient Any opioid prescription and … a. smoking/COPD/emphysema/asthma or other respiratory illness b. renal dysfunction, hepatic disease c. known or suspected concurrent alcohol use d. concurrent benzodiazepine prescription e. concurrent SSRI or TCA anti-depressant prescription Powers, 2012 When is Naloxone Prescribed? (cont’d) 5. Prisoner released from custody 6. Release from opioid detoxification or mandatory abstinence program 7. Voluntary request from patient 8. Patients in methadone or buprenorphine detox/maintenance (for addiction or pain) 9. Patient may have difficulty accessing emergency medical services (distance, remoteness) 10. Other reasons? Powers, 2012 The Prescription Opioid Epidemic • Deaths due to prescription opioid use have more than tripled in the past ten years across the U.S. • Prescription opioids have been linked to a significant increase in overdose deaths in Pennsylvania. CDC, 2014; Sapatkin, 2014 Overdose is Preventable The best strategy for preventing overdose is to address SUD or pain management issues appropriately before they lead to overdose. SAMHSA, 2012