COMPASS
ChicagO Multiethnic Prevention And
Surveillance Study
Habibul Ahsan
Karen Kim, Doriane Miller, Diane Lauderdale, Michelle Le Beau, Dezheng Huo, Brian
Chiu, Andrea King, Funmi Olopade, Sola Olopade, Stacy Lindau, Lainie Ross, Nancy Cox,
Marshall Chin, Kathleen Cagney, Lianne Kurina, Ronald Thisted, Mark Lingen, Geoffrey
Greene, Muhammad Kibriya, Maria Argos, Briseis Aschebrook-Kilfoy
What is COMPASS?
• Its a health study designed by researchers at the University of
Chicago to understand how lifestyle, environment, genetic,
and healthcare-related factors affect health of Chicagoans.
• By identifying the determinants of these diseases, we aim to
help develop new strategies to prevent cancer and other
chronic diseases among Chicago residents.
Rationale
Chronic diseases like cancer, heart disease, stroke, diabetes
and respiratory disease are the biggest causes of disability
and mortality, days lost at work, lower quality of life and
high health care costs.
There is disparity in the distribution of these illnesses, their
known causes and care-related factors across population.
Temporal Trends and Black:White Disparity in
Cancer Rates in Cook County & US [Women]
Cook County
White Females
USA (SEER)
Black Females
1990-1994 2005-2009
1990-1994
2005-2009
White Females
1990-1994
2005-2009
Black Females
1990-1994 2005-2009
rate
rate
% change
rate
rate
% change
B:W IRR
rate
rate
% change
rate
rate
Oral and pharynx
6.0
6.2
3.0
8.2
6.3
-23.0
1.02
7.2
6.4
-11.0
7.2
5.7
-21.0
0.89
Esophagus
2.2
2.0
-9.1
5.9
2.9
-50.1
1.45
2.0
1.9
-5.0
5.1
2.8
-45.1
1.47
Stomach
6.5
6.0
-7.7
9.7
8.7
-10.3
1.45
5.1
4.0
-21.6
9.4
8.6
-8.5
2.15
CRC
49.2
41.8
-15.0
54.4
54.6
3.7
1.31
48.8
39.1
-19.9
58.0
50.3
-13.3
1.29
Liver
1.7
2.9
70.6
2.5
4.0
60.0
1.38
1.5
2.5
66.7
2.7
4.6
70.4
1.84
Pancreas
9.1
11.8
29.7
12.4
16.4
32.2
1.39
9.7
10.6
9.3
14.9
15.4
3.4
1.45
Lung & Bronchus
48.3
56.1
16.1
54.9
66.4
20.9
1.18
50.6
54.3
7.3
54.8
57.3
4.6
1.06
Bladder
10.7
10.6
-0.9
7.9
8.5
7.6
0.8
10.2
9.7
-4.9
7.8
7.3
-6.4
0.75
Kidney
7.4
11.4
54.1
6.5
12.8
96.9
1.12
7.7
10.5
36.4
8.0
12.3
53.8
1.17
Brain
5.6
5.4
-3.6
3.6
3.9
8.3
0.72
6.2
6.0
-3.2
3.6
3.9
8.3
0.65
Breast
134.6
124.1
-7.8
113.1
124.4
9.9
1
135.9
130.6
-3.9
120.4
123.5
2.6
0.95
Cervical
11.4
8.5
-25.4
23.0
15.1
-34.3
1.78
9.3
6.5
-30.1
15.0
8.6
-42.7
1.32
Uterine
26.6
29.2
9.8
15.7
24.1
53.5
0.83
25.8
25.8
0.0
16.2
21.6
33.3
0.84
Ovary
17.1
14.5
-15.2
10.9
10.0
-8.3
0.69
15.9
13.4
-15.7
11.3
10.0
-11.5
0.75
Hodgkins
2.8
2.8
0.0
1.9
2.4
26.3
0.86
2.8
2.9
3.6
2.3
2.5
8.7
0.86
NHL
15.3
16.6
8.5
8.5
10.8
27.1
0.64
15.8
17.7
12.0
9.8
13.2
34.7
0.75
MM
3.7
4.2
13.5
8.8
9.5
8.0
2.26
4.3
4.3
0.0
10.8
11.1
2.8
2.58
Leukemia
9.6
10.0
4.0
6.4
7.5
17.0
0.75
10.4
10.6
2.0
8.8
8.1
-8.0
0.76
Rate is per 100,000 woman-years
% change B:W IRR
Temporal Trends and Black:White Disparity
in Cancer Rates in Cook County & US [Men]
Cook County
White Males
Black Males
1990-1994 2005-2009
rate
rate
Oral and pharynx
15.1
15.9
Esophagus
7.8
Stomach
USA (SEER)
White Males
1990-1994 2005-2009
1990-1994 2005-2009
rate
rate
% change
5.0
25.7
19.5
-24.0
8.8
12.8
19.4
10.2
14.1
11.6
-17.7
22.5
CRC
74.1
57.3
-22.7
Liver
5.0
10.2
Pancreas
11.7
Lung & Bronchus
rate
% change
rate
rate
% change
1.23
18.0
16.2
-10.0
25.6
15.6
-39.0
0.96
-47.4
2.49
7.1
8.4
18.3
17.8
8.0
-55.1
0.95
20.0
-11.1
1.72
11.9
9.1
-23.5
23.2
17.3
-8.5
2.15
72.3
80.0
10.7
1.40
70.5
50.9
-27.8
76.6
63.6
-17.0
1.25
104.0
7.5
14.8
97.3
1.45
4.4
8.5
93.2
8.9
16.8
88.7
1.98
15.2
29.9
16.4
19.9
21.3
1.31
12.5
14.0
12.0
19.5
18.5
-5.1
1.32
93.4
76.7
-17.9
132.7
112.3
-15.3
1.46
93.9
71.5
-23.9
139.3
99.0
-28.9
1.38
Bladder
41.2
39.9
-3.2
15.8
21.1
33.5
0.53
40.7
41.1
0.9
20.7
21.0
-6.4
0.51
Kidney
15.6
20.8
33.3
14.6
25.8
76.7
1.24
15.3
20.2
32.0
17.2
26.0
51.1
1.29
Brain
8.7
7.6
-12.6
4.8
4.5
-6.3
0.59
9.0
8.6
-4.4
4.4
4.4
0.0
0.51
154.9
145.1
-6.3
216.9
248.7
14.6
1.71
200.8
155.4
-22.6
300.4
249.4
-17.0
1.60
Testis
4.9
6.0
22.4
1.2
1.3
8.3
0.22
6.0
6.9
15.0
0.8
1.4
75.0
0.20
Hodgkins
3.3
3.3
0.0
3.2
3.4
6.3
1.03
3.6
3.6
0.0
2.9
3.5
8.7
0.97
NHL
22.5
24.9
10.7
13.1
15.6
19.1
0.63
24.5
26.0
6.1
19.3
18.9
-2.1
0.73
MM
5.6
6.6
17.9
11.3
13.1
15.9
1.98
6.8
7.1
4.4
14.9
15.0
0.7
2.11
Leukemia
15.2
16.4
8.0
11.7
13.8
18.0
0.84
18.1
17.7
-2.0
13.8
13.7
-1.0
0.77
Rate is per 100,000 man-years
B:W IRR
1990-1994 2005-2009
rate
Prostate
% change
Black Males
B:W IRR
Excess Cancer in Women in Cook County
White Females
COOK/SEER
Esophagus
Stomach
crc
Liver
Pancreas
Lung and Bronchus
Urinary Bladder
Kidney and Renal Pelvis
Brain
Breast
Cervix Uteri
Corpus Uteri
Ovary
Hodgkin
NHL
MM
leukemia
IRR is >= 1.00
1.05
1.50
1.07
1.16
1.11
1.03
1.09
1.09
0.96
0.95
1.31
1.13
1.08
0.97
0.94
0.98
0.97
Black Females
COOK/SanFranCo o k/Detro it Co o k/Seattle Co o k/A tlanta
1.11
1.36
1.06
0.83
1.09
1.17
1.13
1.25
1.02
0.88
1.47
1.16
1.02
0.93
0.97
0.93
1.06
1.11
1.36
1.06
0.83
1.09
1.17
1.13
1.25
1.02
0.88
1.47
1.16
1.02
0.93
0.97
0.93
1.06
0.87
1.71
1.11
1.16
1.04
0.91
1.05
0.98
0.86
0.87
1.21
1.14
1.01
1.00
0.84
0.91
0.86
1.05
2.00
1.31
1.32
1.33
1.14
1.39
1.28
1.13
1.00
1.33
1.55
1.04
1.04
1.07
1.24
1.16
COOK/SEER
1.04
1.01
1.09
0.87
1.06
1.16
1.16
1.04
1.08
1.01
1.76
1.12
1.00
0.96
0.82
0.86
0.99
COOK/SanFranCo o k/Detro it Co o k/Seattle Co o k/A tlanta
0.94
1.13
1.11
0.67
1.08
1.07
1.21
1.03
1.08
1.00
2.56
1.16
0.97
0.75
0.72
0.91
1.01
0.85
0.95
1.02
0.78
0.91
0.95
1.05
0.96
1.03
1.00
1.39
1.03
1.00
0.96
0.79
0.78
0.87
0.97
1.00
1.25
0.45
1.21
1.18
1.20
0.96
1.26
1.00
2.60
1.12
1.28
0.60
0.78
0.81
0.68
1.16
0.98
1.09
1.33
1.30
1.47
1.35
1.02
1.08
0.97
1.74
1.29
0.89
1.09
0.90
0.93
1.14
Excess Cancer in Men in Cook County
White Males
COOK/SEER
Esophagus
Stomach
crc
Liver
Pancreas
Lung and Bronchus
Urinary Bladder
Kidney and Renal Pelvis
Brain
Prostate
Testis
Hodgkin
NHL
MM
leukemia
IRR is >= 1.00
1.05
1.27
1.13
1.20
1.09
1.07
0.97
1.03
0.88
0.93
0.87
0.92
0.96
0.93
0.93
Black Males
COOK/SanFranCook/Detroit Cook/Seattle Cook/Atlanta
1.26
1.21
1.15
0.95
1.04
1.36
1.02
1.09
0.94
0.94
0.91
0.94
0.88
0.87
0.96
1.26
1.21
1.15
0.95
1.04
1.36
1.02
1.09
0.94
0.94
0.91
0.94
0.88
0.87
0.96
0.98
1.41
1.16
1.17
1.06
1.02
0.93
0.95
0.90
0.88
0.77
0.87
0.86
0.84
0.84
1.26
1.78
1.39
1.46
1.32
1.18
1.16
1.22
1.04
0.98
1.05
1.06
1.06
1.06
1.21
COOK/SEER COOK/SanFranCook/Detroit Cook/Seattle Cook/Atlanta
1.28
1.16
1.26
0.88
1.08
1.13
1.00
0.99
1.02
1.00
0.93
0.97
0.83
0.87
1.01
1.73
1.18
1.26
0.69
1.29
1.24
0.88
1.07
1.25
1.13
0.62
0.85
0.89
0.94
0.95
1.06
1.05
1.14
0.84
0.87
0.95
0.87
0.86
0.88
0.96
0.87
0.83
0.83
0.80
0.93
1.89
1.42
1.35
0.58
1.24
1.22
0.88
0.72
0.90
1.05
1.63
1.55
0.86
0.73
1.09
1.29
1.32
1.34
1.16
1.28
1.25
1.29
1.21
1.41
0.89
1.00
1.06
0.77
1.01
1.14
COMPASS Broad Goals:
• Novel scientific discovery related to prevention and population science
• Evaluate preventive interventions
• Evaluate health care and disparity related factors
• Create a long-term public health research resource
• Education and training tool for prevention and population sciences
• Outreach, community engagement and population translation
• Ultimately improve the health of the population of Chicago and beyond
Research Scope of COMPASS
Study Design
• Using a longitudinal cohort design.
• This means we will recruit a large random sample of Chicago
population, will measure the factors mentioned above, and then
follow them into the future for assessing health outcomes.
• We will compare the social, biological and contextual
characteristics of the persons who get cancer and other chronic
diseases to those who don’t.
COMPASS Pilot Phase [Funded by UCCCC]
• 3,000 residents representing City of Chicago population
–
–
–
–
1,350 White
1,350 African American
600 Hispanic
300 Asian
• ≥ 35 years
• Ability to complete interview in English
• Citizen or permanent resident
• Enrollment from mid-2013 in 40 Chicago Census Tracts
Where will they be recruited?
Rogers Park
tract 0103, population 6,236
West Ridge
tract 0205, population 6,214
tract 0206.02, population 4,340
Lincoln Square
tract 0409, population 1,950
North Center
tract 0502, population 4,837
Near North Side
tract 0804, population 4,317
tract 8422, population 2,603
Jefferson Park
tract 1104, population 4,352
Albany Park
tract 1403.01, population 2,891
Portage Park
tract 1503, population 7,198
Irving Park
tract 1606.1, population 3,490
Belmont Cragin
tract 1903, population 5,794
Logan Square
tract 2207.02, population 4,060
West Town
tract 2424, population 2,764
Austin
tract 2521.02, population 6,438
North Lawndale
tract 2909, population 4,530
tract 8433, population 1,228
tract 8434, population 1,451
South Lawndale
tract 3012, population 4,012
Near South Side
tract 3302, population 3,806
Armour Square
tract 8411, population 7,254
Douglas
tract 3510, population 3,267
Grand Boulevard
tract 3819, population 1,295
Washington Park
tract 4005, population 2,558
Calumet Heights
tract 4801, population 2,033
Roseland
tract 4907, population 3,085
tract 4908, population 4,007
tract 4913, population 2,886
West Pullman
tract 5305.03, population 5,345
McKinley Park
tract 8404, population 3,326
Bridgeport
tract 8397, population 4,326
tract 8400, population 2,695
Gage Park
tract 6305, population 6,364
West Lawn
tract 6606, population 6,333
West Englewood
tract 6704, population
Ashburn
tract 7002, population 6,609
tract 7004.01, population 5,923
tract 7005.01, population 7,125
Washington Heights
tract 7301, population 2,424
Edgewater
tract 0305, population 6,395
Fieldwork
• Community engagement efforts and advance contacts with
target participants
• Initial consenting/recruitment of subjects at their homes
[supplemented with other methods as needed]
• In-person interview, physical measures, and biological sample
by trained interviewer/phlebotomist
• Permission for follow-up and to access medical records
• Initial focus on cancer and chronic diseases (including CVD,
diabetes and respiratory disease outcomes)
• $50 compensation for effort in participation
COMPASS Long-term Plan
• Seek external funding for project expansion
• Establish a multiethnic cohort of 100,000 adults
representing population of Cook County
• Partnership with other Chicago academic and city/state
institutions and private organizations
• Participate in national and international consortiums
• Enumerate children and family members for future
broader child/family health studies
http://compass.uchicago.edu