Module B: Basic Math for Pharmacology Basic Math • • • • Addition Subtraction Multiplication Division Roman Numerals • • • • • • • I=1 V=5 X = 10 L = 50 C = 100 D = 500 M = 1000 • • • • • • • • Examples: VII = XV = III = IX = IV = XIX = XIV = Fractions • • • • • Simple Proper Improper Mixed numbers Complex Fractions • Reducing to lowest terms – Divide N & D with a common D • Changing improper fractions – Top number is larger than the bottom, divide bottom # into top#. - Write the remainder as a fraction and reduce to lowest terms Fractions • Change mixed #’s into improper fractions – Multiply the whole # by the bottom # – Add total to the top # – Write sum at top; bottom remains same Fractions • Adding and subtracting fractions – If same bottom #, then add the top, bottom remains same. – If D is different, then find the lowest common D. • Adding and Subtracting mixed numbers Fractions • Multiple a Whole # by a fraction – Always reduce to the lowest term – Always change improper fractions • Multiplying two fractions – Use cancellation to speed the process Fractions • Multiplying Mixed #s – Change to an improper fraction • Dividing Fractions – Invert the divisor Decimals • Decimal Places – Numbers on left of decimal are whole numbers – Number on the right of the decimal are as follows: • • • • Tenths Hundredths Thousandths Ten thousandths Decimals • Adding • Subtracting Decimals • Rounding the answer • Multiplying decimals • Dividing decimals – Make the divisor a whole # by moving the decimal – Move the decimal in the dividend the same amount of places as in the divisor. – Place directly above in bracket Decimals • Change decimals to common fractions – Remove decimal – Place appropriate D – Reduce to lowest terms Percents • Change percents to fractions – Ommit percent sign – Use 100 as D – Reduce fraction Percent • Change percent to decimals – Omit percent sign – Insert a decimal point 2 places to the left. Ratios • Indicate the relationship of one quantity to another – Form of fraction – Form of ratio Proportions • Shows how 2 equal ratios are related • Three factors are known • One factor is unknown (x) Systems of Measurements Household Apothecary Metric Household • • • • Most often used by people at home Least accurate Used by nurse in teaching patients Should not be relied on in hospital setting Household Unit Abbreviation Equivalent Drop gtt none teaspoon tsp (t) 1T = 3t Tablespoon tbs (T) Apothecary System • • • • Ancient system “Old English” Not very accurate Use Roman Numerals The symbol is placed in front of the number. • Change to metric system when possible. Apothecary • Weight Unit Abbreviation Equivalent Grain gr *** Apothecary • Volume Unit Abbreviation Equivalent Quart qt Pint pt Fluidounce Dram oz Minim m qt 1 = pt 2 qt 1 = oz 32 pt 1 = oz 16 oz 1= 8 drams Metric System • Base Units – – – – Wt - gram Volume – liter Length – meter Prefixes • • • • • • Centi Milli Micro Deca Hecto Kilo Metric System Weight Volume Length Unit Abbreviation Equivelent gram g 1 g = 1000mg Milligram mg 1 mg = 1000mcg microgram Mcg kilogram kg 1 kg = 1000g liter L 1 L = 1000ml mililiter ml 1ml = 1cc Cubic cent. cc 1cc = 1 ml Meter m 1m=100cm=1000mm centimeter cm 1cm =10mm milimeter mm Other Common Drug Measures • Units = U • Milli unit = mU • Milli equivalent Conversions • Use: – Ratio and Proportion • 1 step problems • 2 step problems • (know) = (want to know) X:Y = X:Y mg : g = mg : g Conversions between systems Metric Apothecary Household Conversion Equivalents 1T 1L pt 1 1g gr xv gr 1 1t 3t 1oz qt 1 500 ml 1 cup 1 kg 1lb 60mg 5 ml 15ml 30 ml pt 2 oz 16 250 ml 2.2 lbs 16 oz ½ oz 6t oz 32 2 cups oz 8 4 cups Drug Calculations Perform Calculation by • Ratio and Proportion or • Dimensional Analysis or • Formula – D/H x Q = X Ratio & Proportion • Ratios you many see: – Wt or strength of a drug in a tab or capsule • Example: 50mg: 1 tab • Meaning : each tablet has 50 mg • Weight or strength of a drug in a volume • Example = 50mg:2ml • Meaning = 50 mg in 2ml of volume Ration & Proportion • When administering medication you can give – Tablets, Capsules, and ml (in a syringe) • Remember: – The ratios must be written in the same sequence of measurements Ratio & Proportion • One step Ratio & Proportion • Two step Ratio & Proportion Dimensional Analysis 1) Identify the desired unit. 2) Identify the equivalent needed and set up in fraction form. 3) Write the equivalent in fraction format, keeping the desired unit in the numerator of the fraction. 4) Be sure to label all factors in the equation. 5) Identify undesired units and cancel them. 6) Perform the mathematical process indicated. Dimensional Analysis • By flipping the fraction, no value is changed. • Remember: They are ratios in fraction form. • Starting the equivalent incorrectly will not allow you to eliminate desired units. • Knowing when the equation is set up correctly is an important part of using Dimensional Analysis. Formulas • • • • D/H x Q = X D = Dose desired Hand = have on hand Q = the quantity or the unit of measure that contains the dose. Formulas • Memorize the formula • Place the information from the problem into the formula in the correct position, with all terms in the formula labeled correctly. • Make sure all measures are in the same units and system of measure or a conversion must be done before calculating the dose. International Units o Units o Milliunits Reconstitution of medications • Stability of the drug • Powder mixed with diluent or solvent • Reconstitute medication before giving to client