NVTH Course Venous Thrombosis – 30 March-1 April 2015 Golden Tulip Hotel Westduin–Koudekerke, Zeeland Monday March 30 12.00 – 13.00 Registration and lunch 13.00 – 13.05 Introduction Jeroen Eikenboom 13.05 – 13.30 Introduction in coagulation and thrombosis Jeroen Eikenboom 13.30 – 14.15 Mechanisms of natural anticoagulants Tilman Hackeng 14.15 – 15.00 Mechanisms of therapeutic anticoagulants Michiel Coppens 15.00 – 15.30 Coffee break 15.30 – 16.10 Acquired risk factors for venous thrombosis Astrid van Hylckama Vlieg 16.10 – 16.50 Genetic risk factors for venous thrombosis ElisabettaCastoldi 16.50 – 17.30 Cancer and venous thrombosis Henri Versteeg 17.30 – 19.30 Dinner 19.30 – 21.00 Masterclass PhD students discuss own research NVTH Course Venous Thrombosis – 30 March-1 April 2015 Golden Tulip Hotel Westduin–Koudekerke, Zeeland Tuesday March 31 08.30 – 09.30 Diagnosis of venous thromboembolism Menno Huisman 09.30 – 10.30 Prevention and treatment of venous thromboembolism Frank Leebeek 10.30 – 11.00 Coffee break 11.00 – 12.00 Mouse models in venous thrombosis research Bart van Vlijmen 12.00 – 13.00 Fibrinolysis Shirley Uitte de Willige 13.00 – 14.00 Lunch 14.00 – 15.00 Post-thrombotic syndrome Arina ten Cate 15.00 – 16.00 Chronic thromboembolic pulmonary hypertension (CTEPH) Erik Klok 16.00 – 17.00 Women’s issues in venous thrombosis Saskia Middeldorp 17.00 - Cooking workshop and dinner NVTH Course Venous Thrombosis – 30 March-1 April 2015 Golden Tulip Hotel Westduin–Koudekerke, Zeeland Wednesday April 1 08.30 – 09.30 Preparation debate Papers 1. Meyer G et al., Fibrinolysis for patients with intermediaterisk pulmonary embolism. N Engl J Med 2014;370:1402-1411 2. van Es N et al., Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials. Blood 2014;124:1968-1975 09.30 – 10.30 Debate 1. Intermediate risk pulmonary embolism should be treated with fibrinolysis: Yes / No Moderator Frank Leebeek 2. Direct oral anticoagulants should become the drugs of first choice for the treatment of acute venous thromboembolism even in absence of antidotes: Yes / No Moderator Pieter Willem Kamphuisen 10.30 – 11.00 Coffee break 11.00 –11.30 Verbindende sessie met de Vereniging Hematologische Laboratoria (VHL) Laboratory measurement of direct oral anticoagulants An Stroobant 11.30 –12.00 Quality control of new assays for direct oral anticoagulants Piet Meijer 12.00 – 13.00 Lunch