Cover Page
The handle http://hdl.handle.net/1887/29578 holds various files of this Leiden University
dissertation.
Author: Krabben, Annemarie
Title: Predictive factors for the development and disease course of rheumatoid arthritis
Issue Date: 2014-10-30
Predictive Factors for the
Development and Disease Course
of Rheumatoid Arthritis
Annemarie Krabben
ISBN: 978-94-6169-559-8
The research presented in this thesis was performed at the department of Rheumatology at the Leiden
University Medical Center, Leiden. The research was financially supported by the Dutch Arthritis Foundation (Reumafonds).
© Annemarie Krabben 2014
No part of this thesis may be reproduced in any form without written permission from the author or,
when appropriate, of the publishers of the publications.
Cover: Studio57 Grafisch Ontwerp
Lay-out and printing: Optima Grafische Communicatie
The publication of this thesis was financially supported by the Dutch Arthritis Foundation (Reumafonds),
Abbvie and Pfizer B.V.
Predictive Factors for the
Development and Disease Course
of Rheumatoid Arthritis
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus prof. Mr. C.J.J.M. Stolker,
volgens het besluit van het College voor Promoties
ter verdediging op 30 oktober 2014
klokke 13:45 uur
door
Annemarie Krabben
geboren te Rotterdam
in 1983
Promotiecommissie:
Promotor:
Prof. dr. T.W.J. Huizinga
Co-promotoren: Dr. A.H.M. van der Helm-van Mil
Dr. M. Reijnierse
Overige leden:
Prof. dr. R.E.M. Toes
Prof. dr. W.F. Lems (VUMC, Amsterdam)
Prof. dr. ir. B.P.F. Lelieveldt
Table of contents
1 General introduction
1
Part I Unclassified arthritis and the risk on development of
rheumatoid arthritis
2 Undifferentiated arthritis characteristics and outcomes when
applying the 2010 and 1987 criteria for rheumatoid arthritis
19
3 Risk on rheumatoid arthritis development in patients with
unclassified arthritis according to the 2010 ACR/EULAR criteria for
rheumatoid arthritis
31
Part II Genetic and serologic factors in predicting
radiographic progression in rheumatoid arthritis
4 Biomarkers for radiographic progression in rheumatoid arthritis
47
5 Genetic variants in IL15 associated with progression of joint
destruction in rheumatoid arthritis, a multi cohort study
97
6 Association of genetic variants in the IL4 and IL4R genes with the
severity of joint damage in rheumatoid arthritis: a study in seven
cohorts
113
7 A genetic variant in Granzyme-B is associated with progression of
joint destruction in rheumatoid arthritis
133
8 Serum pyridinoline levels and prediction of severity of joint
destruction in rheumatoid arthritis
149
Part III MRI in patients with arthralgia and early arthritis
9 Magnetic resonance imaging of hand and foot joints of patients
with ACPA positive arthralgia without clinical arthritis
161
10 Concordance between inflammation at physical examination and on
MRI in early arthritis patients
175
11 MRI detected subclinical joint inflammation is associated with
radiographic progression
199
12 Are rheumatoid arthritis patients discernible from other early
arthritis patients using 1.5T extremity MRI? a large cross-sectional
study
219
Part IV MRI scan protocol revisited
13 Aiming for a shorter rheumatoid arthritis MRI protocol: can
contrast-enhanced MRI replace T2 for the detection of bone
marrow oedema?
237
14 Aiming for a shorter scanning protocol in early arthritis MRI: can
gadolinium contrast administration be eliminated?
251
15 Effect of wearing high-heels on the forefoot: a MRI evaluation
267
16 Summary and general conclusion
273
Nederlandse samenvatting
293
Dankwoord
307
Curriculum Vitae
311
List of publications
313