ANNUAL
RESEARCH
REPORT
2012
Annual Research Report 2012
© ACTA, Maart 2014, Gustav Mahlerlaan 3004, 1081 LA Amsterdam Edited by Design cover Cover 2 : : : T.J.M. van Steenbergen and F.M. Meijer, ACTA Vormgeving en fotografie, Facilitaire Dienst, ACTA Fluorescence photographs of dental plaque Department of Preventive Dentistry, ACTA Academic Centre for Dentistry Amsterdam
CONTENTS INTRODUCTION REPORT OF THE DIRECTOR The Research Institute ACTA Evaluation of the research program Summary of research output and input Societal impact Management PhD students Points of attention Conclusion DESCRIPTION OF PROGRAMS AND RESULTS Oral Infections and Inflammation Oral Regenerative Medicine Other research, including education related research APPENDIX: Impact factors of SCI journals for ACTA publications Name Index page 4 5 5 5 6 9 10 10 13 13 14 48 77 80 81 3 Annual Research Report 2012
INTRODUCTION The annual report starts with chapters containing the annual survey of the director, and overviews of the scientific activities. As in preceding years the scientific performance is thereafter presented for each programme. Detailed information is given of dissertations, scientific publications in refereed journals, other scientific publications, professional publications, indicators of esteem, collaborations and societal impact. Some issues for 2012 are specifically mentioned in this report. These include the two main research themes, i.e. research programs, on which the research of ACTA is focussed starting 2011: “Oral Infections and Inflammation” and “Oral Regenerative Medicine”. An overview of the output in 2012 is presented in Table 1. We are pleased to note that the output in 2012 was high. The number of publications in refereed journals and the IF‐sum have considerably increased over a long period; they are in 2012 comparable to those in recent productive years. In 2012 a total of 13 PhD theses were published. Research Institute ACTA prof.dr. V. Everts director of research dr. T.J.M. van Steenbergen co‐ordinator of research Address ACTA Gustav Mahlerlaan 3004 1081 LA Amsterdam The Netherlands tel: +31‐20‐5980641 e‐mail: tjm.vansteenbergen@acta.nl 4 Academic Centre for Dentistry Amsterdam
REPORT OF THE DIRECTOR The Research Institute ACTA  mission statement Dental research at the Academic Centre for Dentistry (ACTA) focuses on the study of health and diseases of the tissues in and around the oral cavity. Beside infectious diseases like dental caries and periodontal inflammatory processes, attention is paid to the development, function and regenerative capacities of the hard tissues in general, dysfunction of the masticatory system and diseases of salivary glands and oral mucosa. It is the general aim to improve strategies for diagnosis and prevention of diseases and functional repair of the affected tissues in and around the oral cavity. In our attempts to fulfil this mission special care is taken to establish: ‐ integration of basic disciplines with the clinical fields ‐ education and further academic training of PhD‐students ‐ promotion and improvement of the quality of the research in ACTA with special attention to the translation of the results into applications in clinical dentistry. To this end there is a vivid interaction with professional dental organisations and industries.  positioning of the research institute National position. ACTA comprises the combined Faculties of Dentistry of the University of Amsterdam and the VU University Amsterdam. The ACTA Research Institute is the only institute for research of the faculty. National collaboration is organized in the Netherlands Institute of Dental Sciences (Interuniversitair Onderzoekoverleg Tandheelkunde, IOT). The IOT organises among others once a year a 2‐day conference on dental research in the Netherlands. Research themes. ACTA has two main research themes on which research is focussed. These main themes are formed around scientifically strong groups and address relevant clinical topics. The first theme is “Oral Infections and Inflammation”; this theme focuses on the aetiology, prevention and therapy of caries, and periodontal and endodontal infections. The second theme is “Oral Regenerative Medicine”. This theme focuses on the biological process of adaptation and repair of teeth, bone and periodontium, and on biocompatibility of dental materials. Both themes have received a substantial grant from the University of Amsterdam. The ACTA research on oral regenerative medicine is also included in the interfacultary research institute MOVE, a collaboration between the faculty of Human Movement Sciences, the VU University Medical Center and ACTA. Research programs. In previous years, ACTA research was organised in 12 research programs. Following the suggestions of the external review committee in 2008, the research was re‐organised in 2009 in 6 programs. To obtain more focus, starting 2011 the research was reorganised into two new research programs, according to the two main themes: “Oral Infections and Inflammation” and “Oral Regenerative Medicine”. Next to these two major programs, some limited other research is performed, which is education related.  description of output, leading scientific journals in the field The research has a relatively broad focus and deals with questions originating from clinical dental practice. Within the overall research there are considerable variations in the approaches taken, ranging from fundamental medical‐biological to applied clinical. This is reflected in the type of journals in which ACTA researchers publish. Some groups primarily present their findings in journals read in the dental research community, while others also publish in general medical‐biological literature. Evaluation of the research program  external evaluation SEP external evaluation. In 2008 an external evaluation of dental research in the Netherlands was completed according to the new Standard Evaluation Protocol designed by the VSNU. In general, the evaluation committee considered the quality, production, relevance and academic reputation of dental research at ACTA as very good. Based on this report, the director of the research institute has conceived several intentions to 5 Annual Research Report 2012
further strengthen the research at ACTA. For more details about this evaluation we refer to the assessment report of the committee. Semi‐internal evaluation. In 2010 an evaluation of the research of ACTA was performed by a committee consisting of two external referees and two ACTA senior scientists. This committee concluded that ACTA has both nationally and internationally a prominent position in dental research. ACTA is strong in both clinical and fundamental research. The committee recommended continuation of the focus on the two main research themes. SEP internal evaluation. In 2011 an internal evaluation of the ACTA research was performed over the years 2007‐2010. It was concluded that in an international perspective ACTA has a strong position in a relative large number of dental disciplines. Based on the recommendations outlined in that evaluation and on the internal evaluation in 2010 several strategies were made for the future research policy of ACTA. The general strategy is to maintain both fundamental and clinically applied research, preferentially in a translational way. Due to the vulnerability of small groups and to the reductions in budget it was decided to focus the research in two programmes as mentioned above. To preserve the present quality of the research, ACTA will focus on the strongest research. For more details, we refer to the self‐evaluation report. Summary of research output and input Table 1. Comparison of research indicators 2000‐2012 Year 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012
Dissertations 11 9 12 6 12 11 11 12 13 6 18 15 13 Refereed publications 135 130 137 152 170 166 189 185 214 216 196 199 208 First author from ACTA 107 86 85 106 111 130 131 117 159 132 105 103 117 Other scientific publications 24 12 8 12 8 17 13 6 24 12 18 15 14 Professional publications 107 123 75 93 91 99 114 113 98 168 164 169 132 Publications for general public 8 14 9 12 Impact factor sum 176 206 220 238 273 322 344 354 435 509 434 503 493 Personnel WP 1 43.5 45.0 47.2 47.9 49.4 46.0 46.5 50.3 43.4 40.8 36.7 36.2 39.5 WP2 5.2 5.4 5.4 6.2 6.6 4.8 7.9 7.8 9.6 7.0 7.8 10.1 9.4 WP3 8.4 9.5 9.8 10.3 7.7 6.7 7.4 6.5 5.4 12.9 13.5 14.4 17.6 Guests 2.5 2.6 2.4 2.6 1.9 2.2 4.2 4.3 3.6 pm pm pm pm Total personnel 59.6 62.6 64.8 66.9 65.6 59.8 66.1 68.7 62.1 61.6 57.9 60.7 66.5 wp1 = academic personnel funded by 1st source in fte; this includes direct funding by the university wp2 = academic personnel funded by 2nd source in fte; this includes research grants obtained in national competition from NWO, STW and KNAW wp3 = academic personnel funded by 3rd source in fte; this includes research contracts for specific projects obtained from external organisations, such as industry, governmental ministries, European Commission and charity organisations  long time performance Dissertations (PhD theses). The performance of the research institute over a longer period is shown in Table 1. These data show that the number of dissertations per year has fluctuated between 6 and 18. This reflects variations in external collaborations, such as non‐ACTA employees receiving a PhD from our universities and tenure staff members finishing their PhD. In 2012 13 dissertations were accomplished. PhD performance. The percentage of PhD students that finished their thesis averages at 90 % over the last 20 years, and the mean time period between start of employment and defending the thesis is 4.6 years. This figure is corrected for the 0.6 to 0.8 fte employment of several PhD students and for long leave of absence (e.g. maternity and illness) of some PhD students. 6 Academic Centre for Dentistry Amsterdam
Scientific publications. The main attention in the research assessment at the individual and program level is given to publications in scientific journals with a peer review referee system. This category shows a slightly increasing number over the last 20 years, despite a relatively stable input in fte of scientific personnel. The average quality of the publications has significantly improved over the 20‐year period, as judged by the increase of the impact factor sum (Figure 1). In 2012 a high number of 208 refereed publications and a high IF sum was obtained. Professional publications. ACTA scientists are very active in communicating their research findings not only to the scientific community, but also to professionals. The number of professional publications in 2012 was 132. Figure 1. Impact factor sum of ACTA publications, scientific publications in refereed journals, professional publications and total scientific personnel in fte. 600
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 notable events in 2012 Publications in high ranking journals. Outstanding contributions for the year 2012 are publications in relatively high ranking biomedical journals, i.e. Nucleic Acids Research, Cytokine & Growth Factor Reviews, Annals of Surgery, British Journal of Psychiatry and Allergy, four journals with an impact factor higher than 6 and one journal, Nucleic Acids Research, higher than 8. Impact factors. In addition to the output indicators given, the percentage of papers in high impact journals in the field gives valuable information. ACTA published in total 208 scientific papers in refereed journals, of which 193 in journals with an impact factor (SCI journals). 53% of these 193 papers appeared in journals belonging to the field “Dentistry, Oral Surgery and Medicine”. 20% of all publications were in the top 10% of the journals, 43% in the top 25% and 81% in the top 50% (Table 2). This means that, as in previous years, a relatively large number of publications were published in the top journals in the field, both in dental and in non‐dental journals. Indicators of esteem. On a personal level a considerable number of ACTA employees rank in the top of the dental and biomedical research community, as determined by the various indicators of esteem, such as editorships, invited lectures, and congresses organised. In 2012 a total of 21 awards were received by ACTA scientists for their achievements. For more details we refer to the description of the two research programs. 7 Annual Research Report 2012
Table 2. Percentage of publications in different quartiles of dentistry and non‐dental journals dentistry journals non‐dental journals all journals numbers percentage numbers percentage numbers percentage top 10% 26 25% 13 14% 39 20% Quartile 1 43 42% 33 37% 83 43% Quartile 2 37 36% 35 39% 74 38% Quartile 3 13 13% 17 19% 22 10% Quartile 4 10 10% 5 6% 14 7% total 103 100% 90 100% 193 100%  assessment at the program level When the research at the program level is considered, both programs perform in general equally well in terms of most input and output parameters (personnel, PhD students, publications, dissertations etc); see Table 3. Other research (OWI), not related to the two programs, is limited both in terms of input (personnel and budget), and of output. Considering the very limited financial input by ACTA, and the substantial grant for research and development for the dental simulator, the research, in particular the education related research, is considered valuable. Table 3. Summary of the number of publications, impact factor sum and academic personnel in fte Program OII ORM OWI ACTA* Dis 5 9 ‐ 13 Ref publ 119 (58) 98 (60) 3 (2) 208 (117) OSP 10 4 ‐ 14 PP 95 40 11 132 PGP 6 5 1 12 IF 281 224 4 493 wp1 19,10 20,15 0,30 39,55 wp2 6,05 3,35 ‐ 9,40 wp3 8,05 9,20 0,35 17,60 wp tot 33,20 32,70 0,65 66,55 This table summarises the number of scientific publications in refereed journals, the number of other scientific publications, and the number of professional publications. Also the personnel involved in full time equivalent (fte) and the impact factor‐sum (IF‐sum) are included in this table. The IF‐sum was calculated for each program by adding together the impact factor values of all 2011 publications. Dis = number of dissertations Ref publ = number of scientific papers in refereed journals. Between parentheses is the number of first authors belonging to the program in question OSP = other scientific publications (international, refereed) PP = professional publications PGP = publications for the general public IF = sum of impact factors as indexed by ISI. wp1 = academic personnel funded by 1st source in fte wp2 = academic personnel funded by 2nd source in fte wp3 = academic personnel funded by 3rd source in fte wp tot = all academic personnel in fte OII = Oral Infections and Inflammation ORM = Oral Regenerative Medicine OWI = Education Institute and other research * ACTA = the total number of dissertations and papers reflects the total for ACTA; a dissertation or paper was counted only once; the total impact factor sum is not a summation of the data from each program 8 Academic Centre for Dentistry Amsterdam
Table 4: fte of staff and PhD students (see table 2) by type of position Program Staff PhD students Total OII 1st 12,20 2nd 2,60 3rd 3,45 1st 6,90 2nd 3,45 3rd 1,65 33,20 ORM 12,05 1,45 4,45 8,10 1,90 5,35 32,70 OWI 0,30 ‐ 0,35 ‐ ‐ 0.20 0,65 5,35 9,35 66,55 Total OII ORM OWI = = = 24,55 4,05 8,25 15,00 Oral Infections and Inflammation Oral Regenerative Medicine Education Institute and other Research Societal impact  impact on teaching and dental care The prime societal values of a strong research program in a dental discipline are the effect on teaching and on dental care. The research improves the quality of teaching given at ACTA, both for undergraduate students, graduate students, students participating in the post‐initial specialist courses, and for PhD students. New findings and concepts are included in the curriculum at ACTA, but are also presented to dental practitioners at frequently held education activities, e.g. Quality Practice. The Research Institute participates in the ACTA curriculum by offering scientific training to all ACTA dental students. The societal impact of the research of ACTA is also focussed on the influence on patient care, both within ACTA and externally. Research on different main areas of interest contributes to improved prevention, diagnosis and treatment of relevant patient groups. The high number of professional publications contributes to this societal impact. In this annual report the societal impact of each research program is described in more detail in the respective chapters.  functions in the scientific and professional community ACTA employees take an active role as executives in international scientific organisations (61 international functions), as members of editorial boards of scientific journals (77) and in being leading in 'wetenschappelijke verenigingen' of researchers and dental practitioners in the Netherlands. Prof.dr. J.M. ten Cate is appointed as an academy professor at the Royal Academy of Arts and Sciences (KNAW). Furthermore, the societal impact is evident from the organisation of symposia and conferences in the Netherlands and abroad, presentations for dentists, medical specialists and patient groups, memberships of advisory councils, and frequent contacts with the industry. In addition many scientists are also practising as dentists in specialized clinics at ACTA or in the Amsterdam region. Obviously the societal impact of their activities, individually as clinically active professionals and leading among their peers, should be acknowledged. The societal impact is also evident from the relatively large number of 134 professional publications. Some ACTA researchers also wrote popularising publications aimed at a more general audience. Several research findings were high lightened in the general press.  invited lectures and congresses organized In 2012 ACTA researchers have again contributed actively in internationally held meetings, workshops and symposiums, both as organisers and participants. A total of 120 lectures were given as ‘invited speaker’ at international congresses and symposia. In addition a large number of presentations were given at international congresses after selection on submission of abstracts and during congresses and symposia for a Dutch or international audience. Due to this large number, congress abstracts are not listed in this annual report. A total of 7 international meetings were organised by ACTA scientists. 9 Annual Research Report 2012
Management  finances The overall budget of the research institute is divided into a part controlled directly by the directorate and another part that is allocated to the departments. The institute budget (senso stricto) of k€ 948 is used for the management of the institute, the salaries of PhD students and post‐doctoral employees, for travel allowances for these groups, for the organization of courses and for the annual two day IOT research meeting. The research budgets for the departments (in total being k€ 3616) are distributed based on a model containing several parameters, such as external peer review, bibliometric data over the last 5 years, education, PhD theses and external funding. In addition, standard bench fees are issued for PhD students appointed by the research institute. In addition to the university budget (1st source) ACTA scientists were involved in many research projects with external funding. The total amount of research grants (2nd source) was k€ 1357, and the total amount of research contracts (3rd source) was k€ 1790.  personnel The directorate of the institute comprises: prof.dr. V. Everts, director of research 0.4 fte dr. T.J.M. van Steenbergen, co‐ordinator of research 0.6 fte mrs. F.M. Meijer, secretary 0.6 fte mrs. M.H.G. Piek‐Backer, secretary 0.4 fte The activities of the research institute directorate consist of organising scientific meetings with presentations of PhD students, the screening of new research projects, the day‐to‐day interaction with graduate students on practical matters regarding their position, compiling the annual research report, the planning of graduate courses, allocating budgets for research to the departments, controlling the institutes budget and dealing with general correspondence on research issues with UvA, VU etc. PhD students The ACTA PhD training program is organised in the ACTA Graduate School of Dentistry (AGSD). As ACTA has no research master training, the AGSD is at the moment limited to the PhD program.  PhD student appointments All vacancies for PhD positions have been occupied in 2012. In Figure 2 the number of new PhD students at ACTA is shown in the years 1990 to 2012. Over the years, about 23 % of all PhD students had a foreign nationality, about half of them from Europe, the rest from other continents. A mean number of 9 new PhD students were appointed per year. Despite budget restrictions 14 new PhD students, many of them part‐time, could be appointed in 2012. About 40 % of the PhD students have a dental background (see Table 5). Of all PhD students about 50 % is female. The research institute has started a procedure for allocation new PhD positions for the two main research themes. In 2012 five new PhD students were appointed on grants awarded to the research themes in an open competition. Both the open competition and the grants for talented students or post‐docs will be continued in the coming years, however due to budget reductions, in a limited number. 10 Academic Centre for Dentistry Amsterdam
Figure 2. Numbers of new ACTA PhD students from the Netherlands and other countries numbers of PhD students
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Table 5: PhD students by type of undergraduate training program dentistry Dutch dentistry other biology / chemistry psychology medicine other total OII 17 14 17 4 13 7 72 ORM 9 10 10 ‐ 19 14 62 OWI 2 ‐ ‐ ‐ ‐ 1 3 Total OII ORM OWI 28 24 27 4 32 21 136 = = = Oral Infections and Inflammation Oral Regenerative Medicine Education Institute and other research  PhD Courses The following courses are organised for PhD students: “Dentistry for non‐dentist PhD students”, “Writing and Presenting in English”, “Methodology and Statistics”, “Oral Biology” and “Grant Writing”. Dentistry is a multidisciplinary science and the background of the PhD students of ACTA is diverse. Therefore, most PhD students follow external courses on specific research areas, given by experienced lecturers of research schools in other disciplines.  PhD thesis duration and completion rate Attention has been paid to the problems related to the social security benefits of PhD students and the time that PhD students need to finish their thesis. The mean time of 4.6 years between start and defence of the thesis within ACTA is lower than the mean duration of PhD theses in research schools in the Netherlands of 5.1 years (see the report “Rendement en duur van promoties in de Nederlandse onderzoekscholen”, Oost en Sonneveld, 2004). In addition, the mean duration of preparing a thesis shows a slightly declining tendency over the years (Figure 3). 11 Annual Research Report 2012
Figure 3. Mean duration of completing the thesis of ACTA PhD students related to the year of entry
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Over the last 20 years, about 90 % of all PhD students in ACTA completed their thesis (Figure 4). This high percentage is substantially larger than the mean percentage of 75 % of PhD students who finish their thesis in Dutch research schools according to the report by Oost en Sonneveld mentioned above. The external review committee noted in 2008 that they were impressed by the organisation and practice of PhD training and supervision at ACTA. They concluded that it is a well organised programme, with a remarkably high dissertation rate. Figure 4. Percentage of ACTA PhD students finishing their thesis related to the year of entry
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12 Academic Centre for Dentistry Amsterdam
Points of attention  HRM and retirement The research staff at ACTA has been comparatively young in the last decades. This was the result of the merging of the dental schools in the mid 1980’s. Now we are in a situation where heads of departments and senior scientists are retiring. Due to budget restrictions the number of persons involved in research on university (1th source) had to be reduced slightly. Fortunately, the fte scientific personnel on grants (2nd and 3rd source) increased in 2012. Both research priority areas received a substantial grant from the UvA, resulting in an increased 1st fte on 2012.  new building in 2010 In 2010 ACTA moved to a new building located at the VU campus; this brought together groups that were spread out over the city at four different locations. Optimal research facilities at the new ACTA building are available to encourage collaboration between the research groups that require laboratory facilities. The increased number of scientists at one location facilitates to jointly take initiatives, such as in molecular aspects of dental research.  future developments Within the Netherlands, graduate schools are formed at a local level to integrate research training of both Master and PhD students. In 2007 the responsibility for PhD training at ACTA was transferred from the IOT to the ACTA Research Institute. In 2010 the new ACTA Graduate School of Dentistry (AGSD) was formally installed. The research at ACTA has always been characterized by a wide range of different topics that covered most dental disciplines. The present policy is to focus on the two specific research areas with an excellent performance. Collaboration will be increased in the interfacultary research institute MOVE, a collaboration between ACTA, the VU University Medical Center and the faculty of Movement Sciences at the VU University Amsterdam. In coming years the research budget from the 1st source (University budget) might be seriously diminished due to budget restrictions. It will be a big challenge to compete for 2nd and 3rd source grants and to maintain or improve the high output that ACTA has produced in the past. Conclusion The analysis of the various parameters of performance shows that the research at ACTA is, despite of budget restrictions, increasingly improving. Future performance will be dependent among others from the success in obtaining 2nd and 3rd source grants. 13 Annual Research Report 2012
Oral Infections and Inflammation Contact person Prof.dr. B.G. Loos ACTA, Gustav Mahlerlaan 3004 1081 LA Amsterdam Tel: +31‐20‐5980558 E‐mail: b.loos@acta.nl Full professors E. Bloemena C. van Loveren J.M. ten Cate E.A.J.M. Schulten W. Crielaard E.C.I. Veerman J. Hoogstraten G.H.W. Verrips A. de Jongh I. van der Waal J. de Lange P.R. Wesselink G.A. van der Weijden Introduction Oral Infections and Inflammation Oral health is an essential part of the general health of each person during his or her lifetime. Poor oral health, oral infections and inflammation, oral cancer and untreated oral diseases can lead to major health risks such as an increased risk of heart disease, cancer and cancer dissemination, systemic chronic infections and vital organ failure. Poor oral health leads to a lower quality of life and economic hardship. The oral cavity is one of the most infected parts of the body. Most people are completely healthy while thousands of species of microorganisms thrive in their mouth while some develop oral diseases. This research theme of ACTA is involved in (i) many aspects of oral infections and inflammation, (ii) prevention of those, and (iii) understanding the health of the oral cavity as a complex ecosystem, with applications far beyond the oral cavity alone. Translational research and understanding of the functioning of the healthy state of the oral cavity are giving promising perspectives on both new cost‐effective prevention programs for the population as well as economic and social spin‐off product‐innovations in the food sector, oral care products and dental restorative 14 Academic Centre for Dentistry Amsterdam
materials. The dental and medical profession is (re)educated with new knowledge on the fundamentals of normal oral health. In the past years, we have gone through a transition period: the process of integration and subversion of various areas of expertise towards a common theme with clearly more focus and mass: the research priority area “Oral Infections and inflammation”. Our group has demonstrated the international prominence of ACTA in the field of oral health and has acquired a global leadership role in the emerging field of complex ecosystems such as the oral cavity; thus understanding oral infections, inflammatory processes, oral cancer and the definition of a normal, healthy oral cavity including psychosocial factors. We have been awarded a 5 year grant from the University of Amsterdam (UvA) (starting date 1‐1‐2011) and we demonstrated the multiplier effect (both on the academic as well as the economic aspects) by participating in the Top Institute of Food and Nutrition (TIFN) (contract signed December 2011, first year researchwork in 2012). Research objectives Important aspects of the central theme have been studied, in essence with half the scientific community of ACTA, on integrated research areas. These can be grouped as preclinical and clinical objectives. Preclinical objectives An important area concerns the physico‐chemical, biochemical and microbiological aspects of enamel, dentin, dental caries, and infections of the root canal system. The formation, structure and properties of oral and dental biofilms are studied extensively. These aspects are studied by means of various in vitro models which simulate the natural processes in the oral environment and which are designed to evaluate the effects of preventive measures and restorative materials and procedures, thereby covering the field of research from the molecular level up to ex vivo studies. Fluoride that, at present, is still the most effective caries‐preventive agent is subject of study. Research is aimed at a better understanding of its mode of action, also on the molecular level towards microbial metabolism, as well as its possible side effects. In addition to fluoride, antimicrobials have come into focus as caries preventive agents. The efficacy alone or in combination with fluoride is still unknown and application protocols are not yet based on a critical evaluation of experimental and clinical results. The success of antimicrobials in caries prevention is still limited. Modified desinfection methods of the root canal system are studied. New filling methods and contemporary adhesive systems are tested in in vitro leakage models and in clinical studies. The biological functions of the salivary (glyco) proteins are studied and the variation in glandular (glyco) proteins from the submandibular, sublingual and parotid glands. Furthermore there is focus on the biological significance of the whole set of salivary proteinase inhibitors. Synthetic peptide analogues of salivary histatins as broad spectrum antibiotics are developed, particularly to Candida albicans and other selected oral pathogens. Influence of saliva on the interaction of oral microorganisms with oral epithelial cells and the in vitro wound healing capacities of salivary components are measured. Clinical objectives Several studies into pre‐caries and dental erosive lesions involve the role and characteristics of enamel, dentin, and the effects of fluoride, foods and candy. Research is aimed to obtain an in‐depth modern insight in the commensal and pathogenic microflora of the oral cavity, oral infectious processes and diseases, including caries, gingivitis, periodontitis and peri‐implantitis, and its interactions with host cells. A major clinical study to this end has been started in 2012 (to be continued in 2013) with healthy subjects aged 18‐30, to define the “normal” oral cavity. Individual characteristics and specific dental and periodontal characteristics are being recorded. Moreover this has been combined with salivary, blood and plasma parameters, dietary habits and psychosocial factors. Better treatment concepts of dental caries in children are studied, both preventive as well as conservative and in relation to behaviour management. These concepts include ART (Atraumatic Restorative Treatment), the influence of total rehabilitation of the children’s dentition on general and oral health, and consequences of restorative treatment on the child’s coping and anxiety. To study the susceptibility to periodontitis, questions are addressed on the relative role of genetic, environmental and life style factors in the overall initiation and progression of periodontal diseases. Common disease genes are now specially in focus, and various mathematical models to describe the disease have been developed. 15 Annual Research Report 2012
Systemic effects of oral infections are still an important topic. Periodontitis is epidemiologically associated with atherosclerotic forms of cardiovascular diseases (ACVD). We study possible causal relationships to explain this association and the effects of periodontal intervention studies on ACVD biomarkers. And vice versa, which are the effects of the treatment of periodontitis in patients already having ACVD or diabetes. Studies are conducted on the prevention and treatment of gingivitis, periodontitis, and peri‐implantitis. These involve the most effective measures to prevent and control oral health including substantial efforts to reach clinical standards for evidence based dentistry. The effect of conditions known for their potential to impair oral health (such as the use of medical drugs, systemic diseases and psychological stress) on the quality and quantity of saliva is studied. Oral health‐related well‐being and behaviour is studied in dental patients. We aim to improve and to maintain the well‐being of both regular dental patients and subgroups of patients suffering from (extreme forms of) anxiety or (anticipated) pain or from physical/mental handicaps. Moreover, since the well‐being of patients is highly dependent on the treatment they receive from dental professionals, our efforts are also aimed at these dental professionals, lowering stress levels and preventing burnout, helping them in communicating adequately with their patients. Forms of oral cancer, precursor lesions of oral cancer, particularly leukoplakia, odontogenic tumours and salivary gland tumours are studied. Amongst others, the prognostic value of molecular markers is examined with regard to the malignant transformations. A study on peri‐implantitis, implant loss and osteoradionecrosis after irradiation in oral cancer patients focuses on the (long) term complications after oral cancer treatment. A study on the effect of a low intensity laser on intra oral radiation mucositis has been started and participation in a multicenter study to predict clinical outcomes after orofacial tumour resection has been initiated. This last project is a collaboration with AvL/NKI, UMCN and the University of Twente. Clinical outcome studies of root canal treatments in infected root canals using an innovative approach with 3D CBCT scans could give valuable information on different disinfection protocols. Results obtained in 2012 Preclinical studies 
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16 Studies are ongoing on antimicrobial peptides derived from salivary peptides, to combat a variety of pathogens. This are important and novel alternatives fopr conventional antibiotics. Variants of lactoferrin, a salivary protein i.e. lactoferricin, lactoferrampin and a peptide composed of a combination of both peptides (Chimera), were studied for their antimicrobial and antimycobial activity and toxicity. Effects of salivary peptides on oral soft and hard tissue cells are studied. Since LL‐37 deficiency has been related to aggressive periodontitis, the effect of LL‐37 on osteoclastogenesis was studied. It was found LL‐
37 indeed exerts an inhibitory effect on in vitro osteoclastogenesis, as evidenced by the inhibition of a number of processes including formation of multinucleated cells and TRAP expression, Bacterial proteases play an important role in a broad spectrum of processes, including colonization, proliferation, and virulence. In this respect, bacterial proteases are potential diagnostic biomarkers for bacterial diagnosis and targets for novel therapeutic protease inhibitors. To investigate these potential functions, we designed and used a protease substrate fluorescence resonance energy transfer (FRET) library comprising 115 short d‐ and l‐amino‐acid‐containing fluorogenic substrates as a tool to generate proteolytic profiles for a wide range of bacteria. Bacterial specificity of the D‐amino acid substrates was confirmed using enzymes isolated from both eukaryotic and prokaryotic organisms. Overall, the specific characteristic of our substrate peptide library makes it a rapid tool to high‐throughput screen for novel substrates to detect bacterial proteolytic activity. Next‐generation sequencing (NGS) technologies enable deep microbiome profiling. However, selecting the right gene region for sequencing is important. We therefore developed TaxMan: a web‐based tool that trims reference sequences based on selected primer pairs, and returns an assessment of primer specificity, allows taxa plotting, and improves sequence matching algorithms speed. http://www.ibi.vu.nl/programs/taxmanwww/. We further found that, for clustering oral microbial sequence data, pre‐processing steps by both denoising and chimera checking led to best cluster accuracy. Interactions between oral microbes, and microbes and host, are crucial in disease development . Host‐P. gingivalis interactions play an important role in periodontitis. We showed that encapsulated as well as non‐encapsulated P. gingivalis invade host cells, and thereby resist in vitro antibiotic treatment. Cariogenic biofilms may be influenced by the introduction of fluoride, some chemical agents or probiotic bacteria. Using an Active Attachment Biofilm model, we found that the probiotic bacterium L. Rhamnosus GG (LGG) established in saliva‐derived microcosms and reduced S. mutans counts significantly, but did not Academic Centre for Dentistry Amsterdam
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affect pH or dentin demineralization. In C. Glabrata biofilm formation, adherence to a surface mediated through adhesins is an important initial step. We identified the novel adhesins Awp5 and Awp6, Epa3 and the previously identified adhesins Epa6, Awp2 and Awp4. These adhesins were up‐regulated in biofilms and showed medium‐dependent regulation, indicating that many adhesins are involved in C. glabrata biofilm formation. Proper removal of biofilms is important for the treatment of root canal infections. A simple assay is urgently needed for evaluating the effect root canal disinfectants on polymicrobial biofilms. The high‐
throughput, low cost resazurin assay displayed a clear dose response for the effect of sodium hypo chloride (NaOCL) on biofilms and revealed that dual‐species biofilms are 30‐fold more resistant to NaOCl than single‐species, and therefore has a great potential for testing novel root canal antimicrobial agents. We also showed that hyperosmosis significantly reduced E. faecalis and P. aeruginosa in a dual‐species biofilm. Enamel de‐ and remineralization is influenced by microorganisms in plaque. The efficacy of Galla chinensis extract (GCE) in inhibiting demineralization was studied by treating bovine enamel with GCE components, and subject it to pH‐cycling. Gallic acid appeared to be the main effective component and is promissing for the development of anticaries agents. Furthermore, we found that at pH >7.0, chemical changes may occur in GCE, hampering inhibition of demineralization. Various anti‐caries agents may affect cariogenic biofilms. An active attachment biofilm model was applied to evaluate such agents. A combination of LED light and photodynamic treatment partially killed S. mutans biofilms on dentine, and reduced mineral loss and lesion depths. Also, alkali production by arginine catabolism in dental biofilms may have anticaries effects. NH(3) levels and pH of polymicrobial saliva‐
biofilms were analyzed in vitro. Alkali production was optimal at lower pH, hampered by sucrose, and affected by biofilm age and presence of polypeptides and proteins. These factors may influence caries development by affecting acid and base formation. We showed in an in vitro model that fluoride‐releasing restorative materials might cause a chemical altering of dentin into acid‐resistant fluorapatite, which is beneficial for protecting against caries even after fluoride release has diminished. Clinical studies 
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We inititated several clinical studies applying new molecular open‐ended techniques, which do not preselect for certain species, to study the composition of occlusal and supragingival dental plaque, the cariologic microbiota, the subgingival microbiota in periodontal health and disease, the microbiology of endodontic infections. All dental plaques are much more complex than previously thought. Clearly, results point to new, non‐cultivable, fastidious species and these are now recognized also to associated with infectious processes in the oral cavity. Interestingly, we investigated the salivary Candida abundance relative to the bacterial load: microbiomes with high Candida load were less diverse and appeared dominated by saccharolytic, acidogenic streptococci. In oral infections, interactions between oral pathogens and host cells are crucial in the development of disease. We showed that periodontal fibroblasts from patients appeared more prone to recognize and respond to the periodontal pathogen P. gingivalis, and that cells from P. gingivalis culture‐positive persons responded more strongly to P. gingivalis than cells from P. gingivalis‐negative persons. We expand our salivary diagnostic capabilities. From the the knowledge on detecting bacterial enzyme activity of B. anthracis in vivo, we investigate in parallel, specific substrates for P. gingivalis. Using these substrates we have been able to detect the presence of P. gingivalis in saliva and crevicular fluid within minutes, without the need for sample pre‐treatment or enzyme isolation. This was tested in health, periodontitis and peri‐implantitis. Oral microflora may be involved in oral mucositis, a side effect of hematopoietic stem cell transplant (HSCT). We investigated the relationship between oral ulcerations and bacterial species, Candida, and viruses. Oral rinses from HSCT patients were assessed for microbial presence by real‐time PCR, which revealed that mainly P. gingivalis, and P. micra, T. denticola, F. nucleatum, C. glabrata, C. kefyr, and HSV‐1 and EBV may play a role in ulcerative oral mucositis. Furthermore HSV‐1 is a predictor of ulcerations of oral mucosa following HSCT. We continued genetic studies in periodontitis and reviewed the literature. Genetic studies of aggressive periodontitis showed that TLR2 gene variants cannot be considered as a candidate gene. 17 Annual Research Report 2012
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18 The life style factor diet, in particular vitamin C and fruit supplements, is becoming more and more a part of our focus. In a clinical study we found lower vitamin C plasma levels in periodontitis, but intracellular stores of vitamin C are not different between patients and controls. Studies have been performed to systematically evaluate the clinical evidence with respect to the effect of chewing gum on oral health, mouth rinses and bad breath, toothbrush design on plaque removal and various mechanical instruments on the cleaning of dental implant surfaces. The results show that the use of sugar‐free chewing gum as an adjunct to toothbrushing provides a small but significant reduction in plaque scores. The most compelling evidence was provided for chlorhexidine mouthwashes, and those that contained a combination of cetyl pyridinum chloride and zinc provided the best evidence profile on oral malodor. The available evidence indicates that bristle tuft arrangement (flat trim, multilevel, angled) contributes to the variation in observed efficacy. Several projects have focussed on evidence based dentistry related to the prevention and therapy of periodontal diseases and oral halitosis. After validation experiments in assessing oral malodour by organoleptic measures and by using the oral chroma and halimeter, we performed a clinical study assessing the effect of the drinking of a glass of water or the rinsing with water on morning bad breath. Both interventions have an impact on oral malodour outcomes. Using a representative sample from the Dutch population, we examined some psychosocial aspects of halitosis. The results showed that almost 90% of the Dutch population aged 16 years and older were regularly faced with halitosis. A clinical trial was performed on caries‐preventive properties of shiitake mushroom, in which volunteers rinsed with a solution of shiitake fractions, placebo, or active caries inhibitory rinse (Meridol ®). Plaque, acidogenicity, and microbial composition were determined. Rinses with shiitake reduced metabolic activity of plaque, but not plaque scores or acidogenicity, indicating an anticariogenic effect of shiitake extract but less potent than Meridol®. Dental treatment of young children is difficult and sometimes children are referred to a specialist pediatric dentist. Parents of non‐referred and referred paediatric dental patients were asked to fill out the Child Rearing Practices Report (CRPR) and the Child Fear Survey Schedule Dental Subscale (CFSS‐DS) on behalf of their children. Results show that referral status and dental anxiety of 4‐12 year old children were not associated with parental rearing style. The association between complete absence of post‐treatment periapical lesion and the quality of root canal filling was studied with a clinical study in cooperation with the Peking University in Beijing China. This is one of two studies we conducted on the healing of periapical periodontitis. These studies are important in that for the first time 3D CBCT scans are utilized for most higher resolution. Human papilloma virus (HPV) is present squamous cell carcinomas of the oropharynx. We studied the epidemiology and have shown that the incidence of HPV related tumors is increasing over the last 20 years. In general, the prognosis of HPV positive carcinomas is better than the HPV negative tumors. A prognostic model was developed in which patients were classified into three risk groups according to HPV‐
status, nodal stage and comorbidity. The concept of the sentinel biopsy in staging oral cancer has been demonstrated and validated in a large multicentre trial. To firmly establish the diagnosis of oral leukoplakia the histopathological examination of (part of) the lesion should be included. It was shown that DNA ploidy can be of prognostic value in the progression of oral leukoplakia. There is 40‐years experience with the treatment of ameloblastomas. Retrspective study showed that in none of the patients treated by radical surgery a recurrence was observed with a mean follow‐up period of 10.5 years. In 50% of patients treated by enucleation only a recurrence developed in an average period of five years. The histological subtype of ameloblastoma did not influence the treatment outcome. This also applied to the unicystic type. We are further exploring oral health‐related quality of life in people addicted to alcohol or other drugs. If people do not perceive to have oral problems, they will likely not comply with dental treatment and advice. The well‐being of oral surgeons and other dental staff was assessed, looking at levels of burn‐out, job demands and general psychological distress. One quarter of the dental professionals were categorized as having a serious burnout risk. Dentists appeared to have most trouble with work environment aspects: time pressure and financial worries. Studies are ongoing on the efficacy of eye movement desensitization and reprocessing (EMDR), a trauma‐
focused intervention method. EMDR appeared to be effective in post‐traumatic stress disorder (PTSD) symptom severity, and led to a significantly faster recovery than those who received brief eclectic psychotherapy. Academic Centre for Dentistry Amsterdam
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In collaboration with TNO, ACTA once again reported on child dental health in the Netherlands, based on a large scale epidemiologic study that was funded by the Dutch Health Insurance Counsel (TZ report). It appeared the oral health of children was better in 2011 than in 2005, but that there still is much room for oral health improvement. The Dutch minister of health has expressed her appreciation of our studies and committed to financing further studies in this area. Academic personnel in 2012 and 2013 Research staff ACTA – OII (Oral Infections and Inflammation) (in full time equivalents) position Name Bloemena, prof.dr. E. Cate, prof.dr. J.M. ten Crielaard, prof.dr. W. Crielaard, prof.dr. W. Eijkman, prof. dr. M.A.J. Hoogstraten, prof.dr. J. Jongh, prof.dr. A. de Lange prof.dr. J. de Loos, prof.dr. B.G. Full professors Loveren, prof.dr. C. van Loveren, prof.dr. C. van Schulten, prof.dr. E.A.J.M. Veerman, prof.dr. E.C.I. Veerman, prof.dr. E.C.I. Velden, prof.dr. U. van der Verrips, prof.dr. G.H.W. Waal, prof.dr. I. van der Weijden, prof.dr. G.A. van der Wesselink, prof.dr. P.R. Gorter dr. R.C. Steenbergen, dr. T.J.M. van Senior lecturers Strijp, dr. A.J.P. van Strijp, dr. A.J.P. van Strijp, dr. A.J.P. van Aartman, dr. I.H.A. Allard, mr.dr. R.H.B. Alvarez Rodriquez, dds. E. Bikker, dr. F.J. Bikker, dr. F.J. Bolscher, dr. J.G.M. Bonifacio, dr. C.C. Other lecturers and tenured Brand, dr. H.S. research staff Brand, dr. H.S. Brandt, dr. B.W. Dekker, dr. J. den Deng, dr. D.M. Deng, dr. D.M. Dubois, drs. L. Duyx, drs. M.P.M.A. Forouzanfar, dr. T. fte 2012 0,20 0,95 0,20 0,50 pm 0,15 0,40 0,10 0,30 0,20 0,20 0,10 0,60 0,10 pm 0,30 0,20 0,40 0,20 0,40 0,10 0,10 ‐‐ 0,10 0,40 0,10 0,15 0,25 0,65 0,70 0,40 0,40 ‐‐ 0,80 0,05 0,40 0,40 0,10 0,05 0,05 plan 2013 0,20 0,95 0,30 0,40 pm ‐‐ 0,40 0,20 0,30 0,10 0,10 0,10 0,70 ‐‐ pm 0,30 0,20 0,40 pm 0,20 0,10 0,10 0,10 ‐‐ 0,40 0,10 0,30 0,70 ‐‐ 0,70 0,40 0,35 0,05 0,80 0,05 0,40 0,40 0,10 ‐‐ 0,10 funding 1 2 1 3 guest 1 1 1 1 1 3 1 1 3 guest 1 1 3 1 1 1 1 2 3 1 1 3 1 2 1 1 1 2 1 1 1 2 1 1 1 19 Annual Research Report 2012
position Other lecturers and tenured research staff Total tenured staff Non tenured staff PhD students 20 Name Krom, dr. B.P. Krom, dr. B.P. Karagozoglu, drs. K.H. Laine, dr. M.L. Laine, dr. M.L. Ligtenberg, dr. A.J.M. Lindeboom, dr. J.A.H. Nicu, dr. E.A. Özok, dr. A.R. Paraskevas, dr. S.P. Poorterman, dr. J.H.G. Reijden, dr. W.A. van der Schoonheim‐Klein, dr. M.E. Shemesh, dr. H. Soet, dr. J.J. de Soet, dr. J.J. de Veen, dr.ir. M.H. van der Veerkamp, dr. J.S.J. Wijk, dr. A.J. van Wu, dr. M.K. Zaura, dr. E. Zaura, dr. E. Anssari Moin, D. Bots, dr. C.P. Boutsioukis, dr. C. Gambon, dr. D.L. Milstein, dr. D.M.J. Raber‐Durlacher, dr. J.E. Scheres, dr. C.R. Scheres, dr. C.R. Sluis, dr. L.W.M. van der Arikan, msc. M. Benzian, dds. H. Bizzarro, dds.msc. S. Boink, msc. M.A. Bont, P. de Broers, drs. D.L.M. Brouns, drs. E.R.E.A. Cukkemane, msc. N. Dautovic, E. Dekker, drs. H. Dekker, drs. H. Dieleman, msc. A. Dijk, msc. I.A., van Dijk, drs. S., van Donders, drs. H.C.M. Duijster, drs. D. Duijster, drs. D. Elfrink, dr. M.E.C. Fernandez y Mostajo, msc. M. fte 2012 0,75 0,05 0,10 0,15 0,15 0,55 0,05 0,60 0,40 0,10 0,30 0,20 0,20 0,30 0,10 0,10 0,60 0,20 0,40 pm 0,30 0,50 16,80 0,20 pm pm pm 0,20 pm 0,50 0,30 pm 0,05 pm 0,45 0,75 pm pm pm 0,75 pm 0,20 0,25 0,30 0,75 ‐‐ 0,10 0,30 0,45 0,15 0,45 plan 2013 0,70 0,10 0,10 0,25 0,05 0,55 0,05 0,80 0,40 ‐‐ 0,30 0,10 ‐‐ 0,30 0,10 0,10 0,60 ‐‐ 0,40 pm 0,40 0,40 15,70 0,20 pm 0,20 pm 0,20 pm ‐‐ 0,80 pm 0,75 pm 0,45 0,75 pm pm 0,15 0,70 pm 0,20 0,25 ‐‐ 0,75 0,10 0,10 0,30 0,45 ‐‐ 0,45 funding 1 3 1 1 3 1 1 1 1 3 3 1 1 1 1 3 2 1 1 guest 1 3 3 guest 1 guest 1 guest 1 3 guest 3 guest 1 2 guest guest 1 2 guest 1 3 1 2 3 1 1 3 1 3 Academic Centre for Dentistry Amsterdam
position PhD students Name Geurs, N.C. Groot, M. de Gunput, msc. S.T.G. Hansenova Manaskova, msc. S. Helmers, drs. R. Helmers, drs. R. Hertog, drs. D. Houtem, drs. C.M.H.H. van Irshad, drs. M. Imangaliyev msc. S.
Janus, ir. M.M. Jiang, dds. L.M. Jong, msc. B.G. de Jong‐Lenters, drs. M. de Kaiwar, A. Kaman ‐ van Zanten, ing. W.E. Kraneveld, drs. E.A. Koopman, drs. J.E. Koopman, drs. J.E Krikken, drs. J.B. Laheij, drs. A.M.G.A. Leito, ing. J.T.D. Liang, dds. Y.H. Louropoulou, dds. A. Macedo, dds. R.G. de Matse, msc. J.H. May, msc. A. May, msc. A. Metska, dds. M.E. Mevissen‐Renckens, E.H.M. Moghimi, drs. M. Moinzadeh, dds. A.T.M. Neelakantan, dds. P. Papantonopoulos, dds. G.H. Persoon, msc. I.F. Prodan, msc. A. Ramawadh, msc. R.S. Rijkschroeff, msc. P. Roos, C. de Scheerman, msc. J.F.M. Schreuder, W.H. Sijbrandij, drs. T. Sleen, drs. J. van der Slot, drs. D.E. Strydonck, dr. D.A.C. Van Teeuw, msc. W.J. Teeuw, msc. W.J. Tuk, J.C. Veerbeek, H.J. Vermaire, drs. J.H.
Verstraaten, mw. S. fte 2012 pm pm pm 0,75 0,10 ‐‐ pm 0,50 0,75 0,20 0,45 pm 0,55 pm pm pm pm 0,60 0,15 0,20 0,45 pm pm pm pm 0,55 0,20 ‐‐ 0,40 pm 0,15 pm pm pm 0,45 0,30 0,30 ‐‐ pm pm pm 0,75 0,10 0,60 pm 0,45 0,20 pm pm 0,20
pm plan 2013 pm pm pm 0,75 ‐‐ 0,10 pm 0,50 ‐‐ 0,75 0,75 pm 0,75 pm pm pm pm 0,60 0,15 0,05 0,45 pm pm pm 0,60 ‐‐ 0,35 0,40 ‐‐ pm 0,10 pm pm pm 0,45 0,75 0,30 0,45 pm pm pm 0,75 0,10 0,60 ‐‐ 0,40 ‐‐ pm pm ‐‐ pm funding guest guest 1 2 1 3 guest 1 3 3 3 guest 1 guest guest guest guest 1 3 1 1 guest guest guest 1 1 1 3 1 guest 1 guest guest guest 1 3 1 1 guest guest guest 3 3 3 guest 1 3 guest guest 3
guest 21 Annual Research Report 2012
position fte 2012 pm 0,45 0,45 pm pm ‐‐ 16,40
plan 2013 pm 0,45 0,30 ‐‐ pm 0,10 17,75 funding guest 2 1 guest 3 3 total 1 funding 19,10 18,15 1 total 2nd funding 6,05 5,50 2 total 3rd funding 8,05 9,60 3 Total research staff 33,20 33,45 PhD students Total non tenured staff Name Vleugel, B. van der Volgenant, drs. C.M.C. Waal, drs. S.V. van der Weijers, dr. M. Zande, msc. M.M. van der Zecha, drs. J.A.E.M. st
Output Dissertations Bonifacio, C.C. (2012, September 07). The ART of GIC proximal restorations in primary teeth. Universiteit van Amsterdam (189 pag.). Prom./coprom.: prof.dr. C. van Loveren, dr. W.E. van Amerongen & dr. C.J. Kleverlaan. Elfrink, M.E.C. (2012, June 01). Deciduous molar hypomineralisation, its nature and nurture. Universiteit van Amsterdam (157 pag.). Prom./coprom.: prof.dr. J.M. ten Cate, prof.dr. H.A. Moll & dr. J.S.J. Veerkamp. Jiang, L.M. (2012, April 04). Insights into passive ultrasonic irrigation. Universiteit van Amsterdam (116 pag.). Prom./coprom.: prof.dr. P.R. Wesselink, dr. L.W.M. van der Sluis, dr. A.M. Versluis & dr. D.M. Deng. Kieffer, J.M. (2012, January 20). Some fundamental issues in oral health‐related quality of life research. Universiteit van Amsterdam (97 pag.). Prom./coprom.: prof.dr. G.H.W. Verrips & prof.dr. J. Hoogstraten. Weijers, M. (2012, October 29). Oral squamous cell carcinoma; some epidemiological and clinicopathological aspects. VU University Amsterdam (93 pag.). Prom./coprom.: prof.dr. I. van der Waal. Scientific publications (refereed) Bader, O., Schwarz, A., Kraneveld, E.A., Tangwattanchuleeporn, M., Schmidt, P., Jacobsen, M.D., Gross, U., Groot, P.J.W. de & Weig, M. (2012). Gross karyotypic and phenotypic alterations among different progenies of the Candida glabrata CBS138/ATCC2001 reference strain. PLoS One, 7(12), e52218. Beek, M.T. van der, Laheij, A.M.G.A., Raber‐Durlacher, J.E., Borne, P.A. von dem, Wolterbeek, R., Blij‐de Brouwer, C.S. van der, Loveren, C. van, Claas, E.C.J., Kroes, A.C.M., Soet, J.J. de & Vossen, A.C.T.M. (2012). Viral loads and antiviral resistance of herpesviruses and oral ulcerations in hematopoietic stem cell transplant recipients. Bone Marrow Transplantation, 47(9), 1222‐1228. Benzian, H., Holmgren, C., Buijs, M.J., Loveren, C. van, Weijden, F. van der & Palenstein Helderman, W.H. van (2012). Total and free available fluoride in toothpastes in Brunei, Cambodia, Laos, the Netherlands and Suriname. International Dental Journal, 62(4), 213‐221. Blom, T., Slot, D.E., Quirynen, M. & Weijden, G.A. van der (2012). The effect of mouthrinses on oral malodor: a systematic review. International Journal of Dental Hygiene, 10(3), 209‐222. Boers‐Doets, C.B., Epstein, J.B., Raber‐Durlacher, J.E., Ouwerkerk, J., Logan, R.M., Brakenhoff, J.A., Lacouture, M.E. & Gelderblom, H. (2012). Oral adverse events associated with tyrosine kinase and mammalian target of rapamycin inhibitors in renal cell carcinoma: a structured literature review. The oncologist, 17(1), 135‐
144. Bolscher, J., Nazmi, K., Marle, J. van, Hof, W. van 't & Veerman, E. (2012). Chimerization of lactoferricin and lactoferrampin peptides strongly potentiates the killing activity against Candida albicans. Biochemistry and Cell Biology, 90(3), 378‐388. Bonder, M.J., Abeln, S., Zaura, E. & Brandt, B.W. (2012). Comparing clustering and pre‐processing in taxonomy analysis. Bioinformatics, 28(22), 2891‐2897. Bonifacio, C.C., Werner, A. & Kleverlaan, C.J. (2012). Coating glass‐ionomer cements with a nanofilled resin. Acta Odontologica Scandinavica, 70(6), 471‐477. 22 Academic Centre for Dentistry Amsterdam
Bonifacio, C.C., Shimaoka, A.M., Andrade, A.P. de, Raggio, D.P., Amerongen, W.E. van & Carvalho, R.C.R. de (2012). Micro‐mechanical bond strength tests for the assessment of the adhesion of GIC to dentine. Acta Odontologica Scandinavica, 70(6), 555‐563. Brandt, B.W., Bonder, M.J., Huse, S.M. & Zaura, E. (2012). TaxMan: a server to trim rRNA reference databases and inspect taxonomic coverage. Nucleic Acids Research, 40, W82‐W87. Brekel, M.W.M. van den, Lodder, W.L., Stel, H.V., Bloemena, E., Leemans, C.R. & Waal, I. van der (2012). Observer variation in the histopathologic assessment of extranodal tumor spread in lymph node metastases in the neck. Head & Neck, 34(6), 840‐845. Bron, J.L., Mulder, H.W., Vonk, L.A., Doulabi, B.Z., Oudhoff, M.J. & Smit, T.H. (2012). Migration of intervertebral disc cells into dense collagen scaffolds intended for functional replacement. Journal of Materials Science‐Materials in Medicine, 23(3), 813‐821. Brouns, E.R.E.A., Bloemena, E., Belien, J.A.M., Broeckaert, M.A.M., Aartman, I.H.A. & Waal, I. van der (2012). DNA ploidy measurement in oral leukoplakia: Different results between flow and image cytometry. Oral Oncology, 48(7), 636‐640. Cate, J.M. ten & Zaura, E. (2012). The numerous microbial species in oral biofilms: how could antibacterial therapy be effective? Advances in Dental Research, 24(2), 108‐111. Dijkema, T., Terhaard, C.H.J., Roesink, J.M., Raaijmakers, C.P.J., Keijbus, P.A.M. van den, Brand, H.S. & Veerman, E.C.I. (2012). MUC5B levels in submandibular gland saliva of patients treated with radiotherapy for head‐and‐neck cancer: a pilot study. Radiation Oncology, 7(1), 91. Dyrbye, B.A., Dubois, L., Vink, R. & Horn, J. (2012). A patient with clove oil intoxication. Anaesthesia and Intensive Care, 40(2), 365‐366. Elad, S., Epstein, J.B., Raber‐Durlacher, J.E., Donnelly, P. & Strahilevitz, J. (2012). The antimicrobial effect of Iseganan HCl oral solution in patients receiving stomatotoxic chemotherapy: analysis from a multicenter, double‐blind, placebo‐controlled, randomized, phase III clinical trial. Journal of Oral Pathology & Medicine, 41(3), 229‐234. Elfrink, M.E.C., Cate, J.M. ten, Jaddoe, V.W.V., Hofman, A., Moll, H.A. & Veerkamp, J.S.J. (2012). Deciduous molar hypomineralization and molar incisor hypomineralization. Journal of Dental Research, 91(6), 551‐
555. Elfrink, M.E.C. & Weerheijm, K.L. (2012). Molar Incisor Hypomineralisation and Deciduous Molar Hypomineralisation – clinical appearance, prevalence and determinants for its occurrence. Oralprophylaxe & Kinderzahnheilkunde, 34(4), 166‐175. Flach, G.B., Broglie, M.A., Schie, A. van, Bloemena, E., Leemans, C.R., Bree, R. de & Stoeckli, S.J. (2012). Sentinel node biopsy for oral and oropharyngeal squamous cell carcinoma in the previously treated neck. Oral Oncology, 48(1), 85‐89. Flores‐Villasenor, H., Canizalez‐Román, A., Garza, M. de la, Nazmi, K., Bolscher, J.G.M. & Leon‐Sicairos, N. (2012). Lactoferrin and lactoferrin chimera inhibit damage caused by enteropathogenic Escherichia coli in HEp‐2 cells. Biochimie, 94(9), 1935‐1942. Flores‐Villasenor, H., Canizalez‐Roman, A., Velazquez‐Roman, J., Nazmi, K., Bolscher, J.G.M. & Leon‐Sicairos, N. (2012). Protective effects of lactoferrin chimera and bovine lactoferrin in a mouse model of enterohaemorrhagic Escherichia coli O157:H7 infection. Biochemistry and Cell Biology, 93(3), 405‐411. Gabriel, M., Nazmi, K., Dahm, M., Zentner, A., Vahl, C.F. & Strand, D. (2012). Covalent RGD modification of the inner pore surface of polycaprolactone scaffolds. Journal of Biomaterials Science‐Polymer Edition, 23(7), 941‐953. Galassi, F., Kaman, W.E., Anssari Moin, D., Horst, J. van der, Wismeijer, D., Crielaard, W., Laine, M.L., Veerman, E.C.I., Bikker, F.J. & Loos, B.G. (2012). Comparing culture, real‐time PCR and fluorescence resonance energy transfer technology for detection of Porphyromonas gingivalis in patients with or without peri‐implant infections. Journal of Periodontal Research, 47(5), 616‐625. Gambon, D.L., Brand, H.S. & Veerman, E.C.I. (2012). Dental erosion in the 21st century: what is happening to nutritional habits and lifestyle in our society? British Dental Journal, 231(2), 55‐57. Garcia‐Vallejo, J.J., Ambrosini, M., Overbeek, A., Riel, W.E. van, Bloem, K., Unger, W.W.J., Chiodo, F., Bolscher, J.G., Nazmi, K., Kalay, H. & Kooyk, Y. van (2012). Multivalent glycopeptide dendrimers for the targeted delivery of antigens to dendritic cells. Molecular Immunology, 53(4), 387‐397. Gorter, R.C., Jacobs, B.L.T.H. & Allard, R.H.B. (2012). Low burnout risk and high engagement levels among oral and maxillofacial surgeons. European Journal of Oral Sciences, 120(1), 69‐74. Graveland, A.P., Braakhuis, B.J.M., Eerenstein, S.E.J., Bree, R. de, Bloemena, E., Maaker, M. de, Brekel, M.W.M. van den, Dijk, F., Mesker, W.E., Tanke, H.J., Leemans, C.R. & Brakenhoff, R.H. (2012). Molecular diagnosis of minimal residual disease in head and neck cancer patients. Cellular Oncology, 35(5), 367‐375. 23 Annual Research Report 2012
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based dental clinic. European Journal of Dental Education, 16(1), e174‐e179. Schoonheim‐Klein, M.E. (2012). DVD review: feedback strategies in dental education DVD. European Journal of Dental Education, 16(3), 193. Shilya, T., Mukai, Y., Cate, J.M. ten & Teranaka, T. (2012). The caries‐reducing benefit of fluoride‐release from dental restorative materials continues after fluoride‐release has ended. Acta Odontologica Scandinavica, 70(1), 15‐20. Silva, T., Abengozar, M.A., Fernandez‐Reyes, M., Andreu, D., Nazmi, K., Bolscher, J.G.M., Bastos, M. & Rivas, L. (2012). Enhanced leishmanicidal activity of cryptopeptide chimeras from the active N1 domain of bovine lactoferrin. Amino Acids, 43(6), 2265‐2277. Silva, T.C., Pereira, A.F.F., Exterkate, R.A.M., Bagnato, V.S., Buzalaf, M.A.R., Machado, M.A. de A.M., Cate, J.M. ten, Crielaard, W. & Deng, D.M. (2012). Application of an active attachment model as a high‐throughput demineralization biofilm model. Journal of Dentistry, 40(1), 41‐47. Slot, D.E., Timmerman, M.F., Versteeg, P.A., Velden, U. van der & Weijden, F.A. van der (2012). Adjunctive clinical effect of a water‐cooled Nd: YAG laser in a periodontal maintenance care programme: a randomized controlled trial. Journal of Clinical Periodontology, 39(12), 1159‐1165. Slot, D.E., Wiggelinkhuizen, L., Rosema, N.A.M. & Weijden, G.A. van der (2012). The efficacy of manual toothbrushes following a brushing exercise: a systematic review. International Journal of Dental Hygiene, 10(3), 187‐197. Sonoi, N., Soga, Y., Maeda, H., Ichimura, K., Yoshino, T., Aoyama, K., Fujii, N., Maeda, Y., Tanimoto, M., Logan, R., Raber‐Durlacher, J. & Takashiba, S. (2012). Histological and immunohistochemical features of gingival enlargement in a patient with AML. Odontology, 100(2), 254‐257. Spratt, D.A., Daglia, M., Papetti, A., Stauder, M., O'Donnell, D., Ciric, L., Tymon, A., Repetto, B., Signoretto, C., Houri‐Haddad, Y., Feldman, M., Steinberg, D., Lawton, S., Lingstrom, P., Pratten, J., Zaura, E., Gazzani, G., Pruzzo, C. & Wilson, M. (2012). Evaluation of plant and fungal extracts for their potential antigingivitis and anticaries activity. Journal of Biomedicine and Biotechnology, 2012(510198), 1‐12. Steenen, S.A., Dubois, L., Peerooz, S. & Lange, J. de (2012). Ophthalmologic complications after intraoral local anesthesia: case report and review of literature. Oral surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, 113(6), E1‐E5. Strydonck, D.A.C. Van, Slot, D.E., Velden, U. van der & Weijden, F. van der (2012). Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review. Journal of Clinical Periodontology, 39(11), 1042‐1055. Supanchart, C., Thawanaphong, S., Makeudom, A., Bolscher, J.G., Nazmi, K., Kornak, U. & Krisanaprakornkit, S. (2012). The antimicrobial peptide, LL‐37, inhibits in vitro osteoclastogenesis. Journal of Dental Research, 91(11), 1071‐1077. Tahmaseb, A., De Clerck, R., Aartman, I. & Wismeijer, D. (2012). Digital protocol for reference‐based guided surgery and immediate loading: a prospective clinical study. International Journal of Oral & Maxillofacial Implants, 27(5), 1258‐1270. Tariq, M., Bruijs, C., Kok, J. & Krom, B.P. (2012). Link between culture zeta potential homogeneity and Ebp in Enterococcus faecalis. Applied and Environmental Microbiology, 78(7), 2282‐2288. 27 Annual Research Report 2012
Thomas, R.Z., Zijnge, V., Cicek, A., Soet, J.J. de, Harmsen, H.J.M. & Huysmans, M.C.D.N.J.M. (2012). Shifts in the microbial population in relation to in situ caries progression. Caries Research, 46(5), 427‐431. Unger, W.W.J., Beelen, A.J. van, Bruijns, S.C., Joshi, M., Fehres, C.M., Bloois, L. van, Verstege, M.I., Ambrosini, M., Kalay, H., Nazmi, K., Bolscher, J.G., Hooiberg, E., Gruijl, T.D. de, Storm, G. & Kooyk, Y. van (2012). Glycan‐modified liposomes boost CD4(+) and CD8(+) T‐cell responses by targeting DC‐SIGN on dendritic cells. Journal of Controlled Release, 160(1), 88‐95. Veerkamp, J.S.J. (2012). Summary of: comparing the onset of maxillary infiltration local anaesthesia and pain experience using the conventional technique vs the Wand in children. British Dental Journal, 213(9), 460‐
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2206. Vermeulen, F.M.J., Aartman, I.H.A., Kuitert, R. & Zentner, A. (2012). The reliability of assessing rotation of teeth on photographed study casts. The Angle Orthodontist, 82(6), 1033‐1039. Verrips, G., Brouwer, L., Vogels, T., Taal, E., Drossaert, C.H.C., Feeny, D., Verheijden, M. & Verloove‐Vanhorick, P. (2012). Long term follow‐up of health‐related quality of life in young adults born very preterm or with a very low birth weight. Health and Quality of Life Outcomes, 10(49), 10‐49. Voet, K.C., Wu, M.K., Wesselink, P.R. & Shemesh, H. (2012). Removal of gutta‐percha from root canals using the self‐adjusting file. Journal of Endodontics, 38, 1004‐1006. Waal, S.V. van der & Sluis, L.W.M. van der (2012). Potential of calcium to scaffold an endodontic biofilm, thus protecting the micro‐organisms from disinfection. Medical Hypotheses, 79(1), 1‐4. Waal, S.V. van der, Jiang, L.M., Soet, J.J. de, Sluis, L.W.M. van der, Wesselink, P.R. & Crielaard, W. (2012). Sodium chloride and potassium sorbate: a synergistic combination against Enterococcus faecalis biofilms: an in vitro study. European Journal of Oral Sciences, 120(5), 452‐457. Wijk, A.J. van, Lindeboom, J.A., Jongh, A. de, Tuk, J.G. & Hoogstraten, J. (2012). Pain related to mandibular block injections and its relationship with anxiety and previous experiences with dental anesthetics. Oral surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, 114(5), S114‐S119. Zaura, E. (2012). Next‐generation sequencing approaches to understanding the oral microbiome. Advances in Dental Research, 24(2), 81‐85. Özok, A.R., Persoon, I.F., Huse, S.M., Keijser, B.J.F., Wesselink, P.R., Crielaard, W. & Zaura, E. (2012). Ecology of the microbiome of the infected root canal system: a comparison between apical and coronal root segments. International Endodontic Journal, 45(6), 530‐541. Scientific publications (non‐refereed) Brand, H.S. & Vissink, A. (2012). General pathology. In S.L. Noble (Ed.), Clinical textbook of dental hygiene and therapy. Second edition (pp. 32‐52). Chicester: Wiley‐Blackwell. Cate, J.M. ten (2012). New agents for caries prevention: Introduction to ICNARA 2. Advances in Dental Research, 24(2), 27. Cate, J.M. ten (2012). Novel anticaries and remineralizing agents: Prospects for the future. Journal of Dental Research, 91(9), 813‐815. Cate, J.M. ten (2012). The role of saliva in mineral equilibria ‐ caries, erosion and calculus formation. In C. Dawes, W.M. Egar & D. O'Mullane (Eds.), Saliva and Oral Health (pp. 135‐150). UK: Stephen Hancocks Limited. Esposito, M., Nieri, M., Lindeboom, J., Worthington, H., Glenny, A.M. & Schou, S. (2012). Response to letter to the editor: 'Are dental x‐rays associated with an increased risk of meningioma?'. European Journal of Oral Implantology, 5(2), 108. Lopez, R., Loos, B.G. & Baelum, V. (2012). On hematological features in adolescents with periodontitis. Clinical Oral Investigations, 16(6), 1695‐1695. Loveren, C. van (2012). Kariesrisikobewertung und‐ vorhersage. In H. Meyer‐Lückel, S. Paris & K.R. Ekstrand (Eds.), Karies Wissenschat und klinische Praxis. Stuttgart: Thieme Verlag. Schuurs, A.H.B. (2012). Pathology of the hard dental tissues. Chichester: Wiley‐Blackwell. Weijden, G.A. van der (2012). Guest Editorial. International Journal of Dental Hygiene, 10(3), 147. Weijden, G.A. van der & Slot, D.E. (2012). Multi‐disciplinary management of periodontal disease. Proceedings of the 9th Asian Pacific Society of Periodontology Meeting Hong Kong 2011. In P.M. Bartold & L.J. Jin (Eds.), Chapter 3, Interdental oral hygiene: The evidence (pp. 16‐33). Asian Pacific Society of Periodontology. 28 Academic Centre for Dentistry Amsterdam
Professional Publications Amerongen, W.E. van (2012). Moet je bij kinderen wel of niet restaureren? Nederlands Tandartsenblad, 67(7), 18‐21. Avoort, G. van der, Endstra, L., Horst, J. van der & Anssari Moin, D. (2012). Nazorg bij implantaten: diagnostiek en uitvoering. Quality Practice. Nascholingstijdschrift voor mondhygiënisten, 4(4), 13‐28. Baart, J.A., Bretschneider, J.H., Visscher, J.G.A.M. de & Waal, I. van der (2012). Afwijkingen van de sinus maxillaris: een overzicht. Nederlands Tijdschrift voor Tandheelkunde, 119(7‐8), 199‐204. Baiwa, A., Loos, B.G. & Bizzarro, S. (2011). Is parodontitis geassocieerd met vroeggeboorte en laag geboortegewicht? Quality Practice. Nascholingstijdschrift voor tandartsen, 7(2), 45‐52. Barendregt, D.S. (2012). Voorkom elke manipulatie van het parodontaal ligament. Autotransplantatie: de chirurgie. De Tandartspraktijk, 33(11), 13‐18. Bartelsman, J.F.W.M., Depla, A.C.T.M. & Brand, H.S. (2012). Ziekten van het maagdarmkanaal. In H.S. Brand, D.E. van Diermen & P.C. Makkes (Eds.), Algemene ziekteleer voor tandartsen (3e geheel herziene druk) (pp. 177‐195). Houten/Diegem: Bohn Stafleu van Loghum. Boer, I.R. de, Bakker, D.R., Wesselink, P.R. & Vervoorn, J.M. (2012). De Simodont in het onderwijs. Nederlands Tijdschrift voor Tandheelkunde, 119(6), 294‐300. Bots, C.P. & Brand, H.S. (2012). De kracht van speeksel. Nurse Academy, 4, 22‐26. Bots, C.P., Dalen, A. van & Cools, H.J.M. (2012). Lang leve de duurzame medische mondzorg. Nederlands Tijdschrift voor Tandheelkunde, 119(1), 13‐16. Brand, H.S. (2012). Een tandarts dient adequate kennis van de gehele geneeskunde te hebben. Ja. Nederlands Tijdschrift voor Tandheelkunde, 119(11), 526. Brand, H.S. (2012). Gebitsslijtage: Scandinavië ontmoet Nederland. Nederlands Tijdschrift voor Tandheelkunde, 119, 353. Brand, H.S. (2012). Hoofd‐ en halszaken in de huisarts‐ en tandartspraktijk. Nederlands Tijdschrift voor Tandheelkunde, 119, 525. Brand, H.S. (2012). Kijk op medicijnen. Nederlands Tijdschrift voor Tandheelkunde, 119, 341. Brand, H.S. (2012). Maagbescherming bij gebruik van NSAID’s. Nederlands Tijdschrift voor Tandheelkunde, 119, 400. Brand, H.S., Bots, C.P. & Schulte, P.F.J. (2012). Mondgezondheid van patiënten met een bipolaire stoornis. Nurse Academy, 1, 33‐36. Brand, H.S. (2012). Tandartsen moeten bij iedere patiënt het Europese Medisch Risico Registrerend Anamnesesysteem toepassen. Nee. Nederlands Tijdschrift voor Tandheelkunde, 119(9), 409. Brand, H.S. (2012). Tandheelkundestudenten en onderzoek. Nederlands Tijdschrift voor Tandheelkunde, 119(10), 459. Brand, H.S., Visscher, J.G.A.M. de & Poorterman, J.H.G. (2012). Verwijzing van patiënten met niet‐odontogene mondaandoeningen naar een mond‐, kaak‐ en aangezichtschirurg. Nederlands Tijdschrift voor Tandheelkunde, 119(5), 250‐253. Brand, H.S. & Diermen, D.E. van (2012). Acute situaties in de tandheelkundige praktijk. In H.S. Brand, D.E. van Diermen & P.C. Makkes (Eds.), Algemene ziekteleer voor tandartsen (pp. 337‐344). Houten/Diegem: Bohn Stafleu van Loghum. Brands, W.G., Ven, J.M. van der & Eijkman, M.A.J. (2012). Tuchtcollege hekelt onterechte delegatie. Nederlands Tijdschrift voor Tandheelkunde, 119(10), 469‐472. Braun, A.K. & Wesselink, P.R. (2012). Een roze voortand. Quality Practice. Nascholingstijdschrift voor tandartsen, 7(6), 44‐48. Broers, D. & Jongh, A. de (2012). Onbegrepen pijn bij een patiënte met schizofrenie en een borderline persoonlijkheidsstoornis. Quality Practice. Nascholingstijdschrift voor tandartsen, 8(1), 40‐44. Bruchem‐Laheij, A.M.G.A. van & Raber‐Durlacher, J.E. (2012). Orale infecties in de tandheelkunde zonder odontogene oorzaak. Quality Practice. Nascholingstijdschrift voor tandartsen, 8(1), 34‐39. Bruchem‐Laheij, A.M.G.A. van & Raber‐Durlacher, J.E. (2012). Orale infecties in de tandheelkunde zonder odontogene oorzaak. Quality Practice. Nascholingstijdschrift voor mondhygiënisten, 5(1), 31‐36. Cornelissen, J.J. & Brand, H.S. (2012). Kwaadaardige aandoeningen van het immuunsysteem. In H.S. Brand, D.E. van Diermen & P.C. Makkes (Eds.), Algemene ziekteleer voor tandartsen (3e geheel herziene druk) (pp. 63‐70). Houten/Diegem: Bohn Stafleu van Loghum. Crielaard, W. (2012). Orale bacteriën, onze eerste verdedigingslinie. Quality Practice. Nascholingstijdschrift voor mondhygiënisten, 5(1), 21‐24. 29 Annual Research Report 2012
Crielaard, W. (2012). Orale bacteriën, onze eerste verdedigingslinie. Quality Practice. Nascholingstijdschrift voor tandartsen, 8(1), 22‐25. Dekker, J. den (2012). Mondzorg in sociaal perspectief. ‐ 2e dr. Houten: Bohn Stafleu van Loghum. Dekker, J. den (2012). Boekbespreking. Het tandheelkundig jaar 2012 [Bespreking van het boek Het tandheelkundig jaar 2012]. Nederlands Tijdschrift voor Tandheelkunde, 119(9), 452. Diermen, D.E. van, Brand, H.S. & Makkes, P.C. (2012). De medische anamnese in de tandheelkundige praktijk. In H.S. Brand, D.E. van Diermen & P.C. Makkes (Eds.), Algemene ziekteleer voor tandartsen (3e geheel herziene druk) (pp. 13‐20). Houten/Diegem: Bohn Stafleu van Loghum. Dijkstra, J.C., Raber‐Durlacher, J.E. & Loos, B.G. (2012). Veranderingen in geslachtshormonen. In H.S. Brand, D.E. van Diermen & P.C. Makkes (Eds.), Algemene Ziekteleer voor Tandartsen (derde druk) (pp. 239‐245). Houten: Bohn Stafleu van Loghum. Eijkman, M.A.J. (2012). De mondproblemen van koningin Elizabeth I. Nederlands Tijdschrift voor Tandheelkunde, 119(5), 245‐247. Eijkman, M.A.J. (2012). De mondproblemen van Zonnekoning Lodewijk XIV. Nederlands Tijdschrift voor Tandheelkunde, 119(7‐8), 377‐378. Eijkman, M.A.J., Baat, C. de, Beek, H. van, Brand, H.S., Frankenmolen, F.W.A., Liem, S.A., Loveren, C. van, Luijk, A.M. van, Palenstein Helderman, W.H. van, Poorterman, J.H.G., Visscher, J.G.A.M. de & Zeghbroek, L. van (2012). De mondzorg van morgen. Nederlands Tijdschrift voor Tandheelkunde, 119(7‐8), 347. Eijkman, M.A.J. (2012). Ecopraktijk. Nederlands Tijdschrift voor Tandheelkunde, 119, 57. Eijkman, M.A.J. (2012). President George Washington en zijn orale klachten. Nederlands Tijdschrift voor Tandheelkunde, 119(9), 421‐423. Gambon, D.L., Brand, H.S. & Veerman, E.C.I. (2012). Ongezond afslanken. Erosie door appelazijn. Nederlands Tijdschrift voor Tandheelkunde, 119, 589‐591. Gambon, D.L., Veerman, E.C.I. & Brand, H.S. (2012). Risico van erosie door dranken in schoolkantines. Nederlands Tijdschrift voor Tandheelkunde, 119(1), 28‐31. Gorter, R.C. & Ong, T.S. (2012). Professioneel gedrag in het tandheelkundeonderwijs. Nederlands Tijdschrift voor Tandheelkunde, 119(6), 323‐327. Graeff, A. de, Raber‐Durlacher, J.E. & Rietveld, D.H.F. (2012). Oncologie. In H.S. Brand, D.E. van Diermen & P.C. Makkes (Eds.), Algemene Ziekteleer voor Tandartsen (derde druk) (pp. 49‐61). Houten: Bohn Stafleu van Loghum. Groot, J. de & Jongh, A. de (2012). EMDR behandeling van PTSS na seksueel misbruik bij een vaginistitische vrouw: een casus. Tijdschrift voor Seksuologie, 36(3), 197‐199. Hilbrands, L.B., Huysmans, F.T.M. & Brand, H.S. (2012). Aandoeningen van nieren en urinewegen. In H.S. Brand, D.E. van Diermen & P.C. Makkes (Eds.), Algemene ziekteleer voor tandartsen (3e geheel herziene druk) (pp. 137‐152). Houten/Diegem: Bohn Stafleu van Loghum. Houtem, C.M.H.H. van & Vermaire, J.H. (2012). Belemmeringen bij de behandeling. Nederlands Tijdschrift voor Mondhygiëne, 18(7), 22‐25. Houtem, C.M.H.H. van & Vermaire, J.H. (2012). Belemmeringen bij de behandeling deel 2. Nederlands Tijdschrift voor Mondhygiëne, 18(8). Iskender, S.Y., Eekhoff, E.M.W. & Waal, I. van der (2012). Bisfosfonaatgerelateerde osteonecrose van de kaak. Nederlands Tijdschrift voor Tandheelkunde, 119(4), 206‐211. Jongh, A. de & Roeters, F.J.M. (2012). Een mooi gebit, een waardevol bezit. Quality Practice. Nascholingstijdschrift voor tandartsen, 8(2), 8‐13. Jongh, A. de, Baat, C. de & Horstman, M. (2012). Pschosociale aspecten van halitose. Nederlands Tijdschrift voor Tandheelkunde, 119(9), 436‐440. Jongh, A. de (2012). De moeilijk behandelbare patiënt in de tandartspraktijk. In J.K.M. Aps, H.S. Brand, J. Duyck, R.J.J. van Es, R. Jacobs & A. Vissink (Eds.), Het Tandheelkundig Jaar 2013, eerste druk 06‐12‐2012 (pp. 71‐84). Houten: Bohn Stafleu van Loghum. Jongh, A. de & Broeke, E. ten (2012). Eye Movement Desensitization and Reprocessing (EMDR). In E. Vermetten, R.J. Kleber & O. van der Hart (Eds.), Handboek Posttraumatische Stress Stoornissen (pp. 533‐
542). De Tijdstroom. Karagozoglu, K.H., Eerenstein, S.E.J. & Waal, I. van der (2012). Een Afrikaanse man met een zwelling in de hals. Nederlands Tijdschrift voor Tandheelkunde, 119(1), 18‐20. Kostermans, I.A.A.D., Abdoel, S.F. & Rhemrev, G.E. (2012). Recessiebedekking met bindweefselimplantaat. De Tandartspraktijk, 33(6), 4‐17. Krikken, J. (2012). Behandelmogelijkheden bij het oplossen van diepe carieuze laesies bij kinderen. Deel 4. Partiële pulpotomie, (volledige) pulpotomie en pulpectomie. Mondhygiënisten Vademecum, 10(1‐2), 1‐2. 30 Academic Centre for Dentistry Amsterdam
Krikken, J. (2012). Behandelmogelijkheden bij het oplossen van diepe carieuze laesies bij kinderen. Deel 5. Extractie en slot. Mondhygiënisten Vademecum, 10(5), 1‐2. Krom, B.P. (2012). Antibiotica; Een overzicht voor tandheelkundige professionals. Quality Practice. Nascholingstijdschrift voor tandartsen, 8(1), 27‐32. Krom, B.P. (2012). Antibiotica; Een overzicht voor tandheelkundige professionals. Quality Practice. Nascholingstijdschrift voor mondhygiënisten, 5(1), 25‐30. Laar, J.M. van, Michels‐Amelsfort, J.M.R. van & Brand, H.S. (2012). Reumatische ziekten. In H.S. Brand, D.E. van Diermen & P.C. Makkes (Eds.), Algemene ziekteleer voor tandartsen (3e geheel herziene druk) (pp. 259‐
277). Houten/Diegem: Bohn Stafleu van Loghum. Laat, E. de, Boonstra, A.B., Jangkegt, E.M., Wijk, A.J. van & Verrips, G.H.W. (2012). De relatie tussen kwaliteit van leven en mondgezondheid bij mensen met een ernstige meervoudige beperking. Nederlands Tijdschrift voor de Gezondheidszorg, 3, 189‐200. Lieshout, J.J. van, Montfrans, G.A. van & Brand, H.S. (2012). Hypertensie en circulatiestoornissen. In H.S. Brand, D.E. van Diermen & P.C. Makkes (Eds.), Algemene ziekteleer voor tandartsen (3e geheel herziene druk) (pp. 101‐111). Houten/Diegem: Bohn Stafleu van Loghum. Loveren, C. van (2011). De PICO‐vraag. Quality Practice. Nascholingstijdschrift voor tandartsen, 5(6), 28‐32. Loveren, C. van (2012). Een tandarts dient adequate kennis van de gehele geneeskunde te hebben. Nee. Nederlands Tijdschrift voor Tandheelkunde, 119(11), 527. Loveren, C. van & Fokker, A.M. (2012). Voeding en mond‐ en tandziekten. In Supplement 80 Informatorium voor Voeding en Diëtetiek. Houten: Bohn Stafleu van Loghum. Nieuwland, A.C., Vierhout, I., Eekhoff, E.M.W. & Waal, I. van der (2012). Een adolescente jongen met fibreuze dysplasie van het kaakbot. Nederlands Tijdschrift voor Tandheelkunde, 119(11), 541‐545. Nijdam, M.J., Gersons, B.P.R., Jongh, A. de, Reitsma, J.B. & Olff, M. (2012). Psychotherapie voor posttraumatische stressstoornis: directe vergelijking van twee behandelingen. Tijdschrift voor Psychiatrie, 54, 397‐398. Nolte, J.W., Baart, J.A. & Waal, I. van der (2012). Een gingivahyperplasie op basis van neurofibromatose. Nederlands Tijdschrift voor Tandheelkunde, 119(4), 173‐174. Persoon, I.F., Veen, M.H. van der & Crielaard, W. (2012). Cariës de wereld uit. Quality Practice. Nascholingstijdschrift voor tandartsen, 7(5), 20‐28. Poorterman, J.H.G. & Vermaire, J.H. (2012). De waarde van bitewing röntgenfoto’s bij 6‐jarige kinderen. Quality Practice. Nascholingstijdschrift voor tandartsen, 7(4), 40‐43. Raber‐Durlacher, J.E., Boers‐Doets, C. & Graeff, A. de (2012). Bijwerkingen van doelgerichte kankertherapieën; Mondklachten. De Tandartspraktijk, 33(9), 26‐31. Raber‐Durlacher, J.E. & Lust‐Lustig, K.H.M.E. de (2012). Wat is een stamceltransplantatie, welke mondproblemen kunnen zich daarbij voordoen en wat kan de mondhygiënist bijdragen aan de preventie en behandeling daarvan? Mondhygiënisten Vademecum, 10(8), 1‐4. Rhemrev, G.E. (2012). Het mucogingivale complex rondom implantaten. Indicatie stellen. De Tandartspraktijk, 33(12), 11‐15. Riet, T.C.T. van, Frank, M.H. & Lange, J. de (2012). Multiple spontane odontogene absessen bij familiaire hypofosfatemische rachitis. Nederlands Tijdschrift voor Tandheelkunde, 119(7‐8), 368‐372. Schilder, I. & Hunnik, M. van (2012). Melding en preventie van prikaccidenten. Nederlands Tandartsenblad, 67(3), 20‐23. Schoonheim‐Klein, M.E., Selms, M.K.A. van, Volgenant, C.M.C., Wiegman, H.P. & Vervoorn, J.M. (2012). Het beoordelen van de klinische competenties van studenten tandheelkunde. Nederlands Tijdschrift voor Tandheelkunde, 119(6), 328‐336. Schoonheim‐Klein, M.E. (2012). Onderwijsvernieuwingen in opleidingen tandheelkunde. Nederlands Tijdschrift voor Tandheelkunde, 119(6), 271. Shemesh, H. & Wesselink, P.R. (2012). Een nieuwe kroon, een nieuwe endo? Quality Practice. Nascholingstijdschrift voor tandartsen, 7(6), 37‐42. Steenbergen, T.J.M. van (2012). Genetica van het kapsel van Porphyromonas gingivalis [Bespreking van het boek Genetic Background of Porphyromonas gingivalis capsule biosynthesis]. Ned. tijdschr. tandheelkd., 119(1), 43. Steltenpool, C.A.M., Jongh, A. de & Broers, D.L.M. (2012). Een patiënt met familiaire hypofosfatemistische rachitis. Quality Practice. Nascholingstijdschrift voor tandartsen, 7(4), 21‐25. Tack, C.J., Stehouwer, C.D.A. & Brand, H.S. (2012). Diabetes mellitis. In H.S. Brand, D.E. van Diermen & P.C. Makkes (Eds.), Algemene ziekteleer voor tandartsen (3e herziene druk) (pp. 207‐220). Houten/Diegem: Bohn Stafleu van Loghum. 31 Annual Research Report 2012
Tjon, C.S. & Jongh, A. de (2012). Casus: een patiënt met een stikfobie. Quality Practice. Nascholingstijdschrift voor tandartsen, 7(4), 12‐16. Veerman, E.C.I., Brand, H.S. & Oudhoff, M.J. (2012). Waarom we onze wonden likken: speeksel en wondgenezing. In J.K.M. Aps, H.S. Brand, J. Duyck, R.J.J. van Es, R. Jacobs & A. Vissink (Eds.), Het Tandheelkundig Jaar 2013, eerste druk 06‐12‐2012 (pp. 227‐237). Houten: Bohn Stafleu van Loghum. Velthoven, H.J.F.P.M. van, Jongh, A. de & Kraaijenhagen‐Oostinga, A.E. (2012). Dentofaciale afwijkingen bij het syndroom van Klinefelter. Quality Practice. Nascholingstijdschrift voor tandartsen, 7(4), 26‐30. Verrips, G.H.W. (2012). Mondzorg en kwaliteit van leven: de grenzen verkend. Quality Practice. Nascholingstijdschrift voor tandartsen, 7(5), 16‐19. Vijfeijken, S.E.C.M. van de, Karagozoglu, K.H., Rietveld, D.H.F., Meester, M.M.C. & Waal, I. van der (2012). Osteoradionecrose van de mandibula, vermoedelijk veroorzaakt door een frameprothese. Nederlands Tijdschrift voor Tandheelkunde, 199(9), 413‐414. Waal, I. van der (2012). Kaakbotkanker; een valkuil. De Tandartspraktijk, 33(1), 30‐31. Waal, I. van der (2012). Boekbespreking. Algemene ziekteleer voor tandartsen. Inhoudelijk en waardevol [Bespreking van het boek Algemene ziekteleer voor tandartsen. Derde, geheel herziene druk]. Nederlands Tandartsenblad, 67, 33. Warnsinck, C.J. (2012). Niet‐odontogene tandpijn. Quality Practice. Nascholingstijdschrift voor tandartsen, 7(6), 8‐16. Warnsinck, C.J. (2012). Overwegingen bij een niet‐pijnlijke parodontitis apicalis na endodontische behandeling. Quality Practice. Nascholingstijdschrift voor tandartsen, 7(6), 28‐34. Weijden, G.A. van der (2012). (1) Kan zandstralen (de air‐flow) het glazuur of dentine (bij blootliggende tandhalzen) aantasten? (2) Zo ja, hoe vaak per jaar mag je de air‐flow gebruiken zonder schade aan te richten? Mondhygiënisten Vademecum, 10(6), 3‐7. Weijden, G.A. van der & Slot, D.E. (2012). Ein Blick auf elektrische Zahnbürsten – von der sicheren Seite. Aus Wissenschaft und Praxis. Die ZahnarztWoche, 42(12), 10‐11. Weijden, G.A. van der & Slot, D.E. (2012). Quando una pulizia dei denti può veramente definirsi efficace. Hygiene Tribune Italian Edition, anno V(3), 14‐15. Weijden, G.A. van der & Slot, D.E. (2012). The effectiveness of toothbrushing. Dental Tribune, 2(11). Weijden, G.A. van der & Slot, D.E. (2012). Ein Blick auf elektrische Zahnbürsten – von der sicheren Seite. Zusammenfassung einer aktuellen Meta‐Analyse. In M. Neubert & T. Burdett (Eds.), Initiative sanfte mundpflege, REVIEW_SAMMMLUNG (pp. 30‐36). Schwalbach am Taunus, Deutschland: Proctor & Gamble GmbH. Wesselink, P.R. (2012). Pijn bij of na de wortelkanaalbehandeling. Quality Practice. Nascholingstijdschrift voor tandartsen, 7(6), 18‐26. Wijs, R.W., Meleti, M., Waal, I. van der & Bloemena, E. (2012). Een niet‐gepigmenteerde naevus als ongewone gingivazwelling. Nederlands Tijdschrift voor Tandheelkunde, 119(6), 283‐284. Zaura, E. & Krom, B.P. (2012). Microbiologie voor en na de milleniumwisseling. Quality Practice. Nascholingstijdschrift voor mondhygiënisten, 5(1), 8‐13. Zaura, E. & Krom, B.P. (2012). Microbiologie voor en na de milleniumwisseling. Quality Practice. Nascholingstijdschrift voor tandartsen, 8(1), 8‐13. Publications for the general public Eijkman, M.A.J. (30‐10‐2012). Gezonde bacterieflora in de mond houdt bloeddruk goed. NRC Handelsblad Eijkman, M.A.J. (07‐07‐2012). Kinderen zonder blijvende tanden vroeg helpen. NRC Handelsblad Eijkman, M.A.J. (02‐06‐2012). Meer tandbederf met kaaskiezen. NRC Handelsblad Eijkman, M.A.J. (04‐02‐2012). Spoelen schaadt mondbacteriën. NRC Handelsblad Jongh, A. de (25‐03‐2012). Overigens. De rechter moet mensen die hun kind ernstig hebben mishandeld of hebben vermoord, kunnen verplichten tot anticonceptie. Folia Magazine, pp. 45. Waal, I. van der (2012). Mondbranden. Alles over het gebit. NMT patiëntenplatform, 5. Patents Valentijn‐Benz, M., Hof, W. van 't, Bikker, F.J. & Veerman, E.C.I. (2012) Protection of materials by sphingosine based compounds, P97560EP10, 10 Oct 2012. Waal, S.V. van der (2012) Nikinc pharma dental BV. NL2004260‐C, 22‐08‐2012, WO2011102724‐A2, 25 August 2012. 32 Academic Centre for Dentistry Amsterdam
Indicators of Esteem Grants: current projects with external funding Bikker, F.J. & Veerman, E.C.I., Defensie/TNO. Application of antimicrobial peptides as anti‐warfare therapeutics. 2010‐2014: € 280.000. Bloemena, E. ICTO grant: Meer (web)micro. € 10.000 Cate J.M. ten, Academy Professor, Royal Netherlands Academy of Arts and Sciences (KNAW), € 1.000.000,‐
period 2008‐2013. Cate ten J.M. ten, Crielaard W., Soet J.J. de & Loveren C. van STW project. Seeing is believing. M.H. van der Veen & C.M.C. Volgenant . Start October 2010 ‐ October 2016, € 500.000,‐ Cate ten, J.M., In vivo studies on the effects of using a novel toothpaste on the etiology of dental caries. Total budget for ACTA €360.000,‐ from Colgate Palmolive, USA. Start January 2009 ‐ January 2012. Crielaard, W., Preventive Dentistry, Periodontology, Oral Biochemistry, Cariology,, TIFN Oral Health (2012‐
2016): Public Private Partnership funded by the Dutch Ministry of Economic Affairs, Wrigley, Philips Research, Gargill, GlaxoSmithKline, TNO, WUR & ACTA (Total investment 5.2 M€). Crielaard, W., Zaura, E. & Buijs, M.J., EU (FP7) grant for the project no. 241446: ANTIRESDEV. “The effects of antibiotic administration on the emergence and persistence of antibiotic‐resistant bacteria in humans and on the composition of the indigenous microbiotas at various body sites”. Total budget for ACTA: € 359.036. Start: November 1, 2009 – October 31, 2012. Coordinator: University College London. Exterkate, R.A.M. & Cate, J.M. ten. Effect of the product S‐PRG BARRIER COAT on biofilm formation and metabolism. Shofu Inc., Japan. €10.000. Exterkate, R.A.M. & Cate, J.M. ten. Short report on the anti‐bacterial effect of 4 test rinses in an Active Attachment Biofilm model. GABA, Switzerland €15.000. Exterkate, R.A.M. & Cate, J.M. ten. Short report on the anti‐bacterial effect of 6 test rinses in an Active Attachment Biofilm model. GABA, Switzerland €15.000. Exterkate, R.A.M. & Cate, J.M. ten. Short report on the anti‐bacterial effect of 6 test rinses in an Active Attachment Biofilm model. First series – May 2012. Exterkate, R.A.M. & Cate, J.M. ten. Short report on the anti‐bacterial effect of 4 test rinses in an Active Attachment Biofilm model. Second series – May 2012. Exterkate, R.A.M. & Crielaard W. Evaluation of Petrifilm and ATP measurement in the monitoring of dental unit water. 3M Healtcare Benelux. Exterkate, R.A.M. & Crielaard W. Evaluation of Petrifilm in monitoring dental unit water. 3M Healthcare Benelux. Exterkate, R.A.M., Willems, H.M.E. & Cate, J.M. ten. Effect of experimental toothpastes on the de‐
/remineralization of enamel and dentin. Part 1 calcium data. GABA, Switzerland. Exterkate, R.A.M., Zaura, E., Crielaard, W., & Cate, J.M. ten. Development and evaluation of relevant dental in vitro biofilm models for the screening of new active compounds. Report January – June 2012. GABA, Switzerland. Gorter R.C. & Wismeijer, D. International Team for Implantology (ITI): Digital dentistry in practice; on dentists’ interaction with technological transformations. First part of PhD project funding, in collaboration with Oral Implantology. February 2012 – December 2013: 110.000,‐ euro. Krom, B.P. Interspecies interactions as targets to fight burnwound infections, Nederlandse Brandwonden Stichting, € 194.162,00, start 01‐09‐2012, end 31‐8‐2014. Laheij, A.M.G.A., Loveren, C. van, Soet, J.J. de & Balm, A.J. (Netherlands Cancer Institute/Antonie van Leeuwenhoek Hospital). Prospective study of changes in the oral biofilm and the protein composition of saliva in patients, being irradiated for a tumour in the head‐and‐neck area. GABA International AG. Dept. Scientific Affairs, Therwill, Switzerland. Laine, M.L.:Nuffic international PhD project financing, 2012. Higher Education Commission (HEC)‐Pakistanon €7.000,‐. Loos, B.G. “Microbiome of periimplant sulcus/pocket: A pyrosequencing study on the microflora of periimplant health and disease” (2011‐2012). A grant by the Deutsche Gesellschaft fur Parodontologie, € 50,000.‐ . Loos, B.G. “Oral health” (2011‐2015) University of Amsterdam/focuspoint. Joint effort Prof.dr J.M. ten Cate, prof. W. Crielaard, Prof. dr. B.G. Loos, Prof. dr. E. Veerman. Dept. of Conservative and Preventive Dentistry, ACTA. €1.308,000.‐. Loos, B.G. “Regenerative surgical treatment of peri‐implant osseous defects ‐ a multicenter randomized prospective clinical study” (2011‐2012) A grant supplied by Tigran AB, Sweden, € 20,000.‐ . 33 Annual Research Report 2012
Loos, B.G. “The effect of daily dietary intake of dried juice concentrates of fruit, vegetables and berries (Juice Plus+) upon periodontal outcomes in chronic periodontitis: a multi‐centre RCT” (2010‐2012) A grant supplied by JuicePlus, USA, € 71,830.‐. Loveren van, C. , Weijden, G.A van der & Slot, D.E. Roquette. The effect of malitol sweetened chewing gum on caries risk factors of dental plaque and saliva, and on the development of gingivitis in a 21 day non‐
brushing study model, € 312.275,‐. Matse, J.H. Rene Vogels reisbeurs € 2400 and KWF Reisbeurs voor Academici € 2100 of a project between 01/01/2012 ‐ 16/3/2012. Schoonheim‐Klein, M.E. NIH (2011‐2016) in cooperation with Harvard, UCSF and Creighton US$ 100.000,‐ . Sluis, L.W.M . van der, Ultrasonic cleaning of root canals. STW € 920.702,‐. Start : September 2007‐ September 2012. Soet de, J.J. & Crielaard, W. Biofilm composition and secondary caries in situ and in vivo. $ 955,606.00 from NIH. Start: September 2010 ‐ September 2014. Strijp van A.J.P., Extraction of intra‐oral plaque samples by wearing an in situ device. Philips Research, the Netherlands. March 2011‐ April 2012. € 5.000,‐ Veen van der, M.H. & Kaaij van der N.C., The use of fluoride rinse for caries prevention during the orthodontic treatment with fixed appliances. GABA. Start August 2009‐december 2012, €180.000,‐. Veerman, E.C.I. & Bikker, F.J., NWO‐ZONMW Exploiting Staphylococcus aureus sortase for anti‐infective purposes. 2010‐2014: € 336, 923. Veerman, E.C.I., Bolscher, J.G.M., Gibbs, S.,& Schepers, R., Technology Foundation STW. Novel saliva‐derived peptides for state‐of‐the‐art clinical wound‐healing applications. 2010‐2014: € 641.317. Veerman, E.C.I., Ligtenberg, A.J.M. & Bolscher, J.G.M., Technology Foundation STW. Development of protective coatings. € 836, 397. Veerman, E.C.I., NWO‐ALW. How histatin enhances wound closure: structural and cellular aspects. 2010‐2014: € 280.013. Weijden, G.A. van der, N.A.M. Rosema, D.E. Slot, C.E. Berchier, P.A. Versteeg, N.L. Hoenderdos, U. van der Velden & A.J. van Winkelhof. Prevention of plaque and gingivitis: A 6‐months placebo‐controlled high‐
bioavailability‐cpc‐mouthrinse study. (DENTAID) € 78.200,‐. Weijden, G.A. van der, N.A.M. Rosema, N.L. Hoenderdos, G. van Anraat, C.E. Berchier, P.A. Versteeg & D.E. Slot. Preventive strategies in order to obtain healthy teeth for life. (ZonMW). € 163.985,‐. Weijden, G.A. van der, N.A.M. Rosema, N.L. Hoenderdos, D.E. Slot, C.E. Berchier, & P.A. Versteeg. The effect of different interdental cleaning devices on plaque biofilm and gingival bleeding. (WATERPIK) € 79.877,‐. Wesselink, P.R., Ministery OCW € 850.000,‐. Simodont project for three years 2008‐2010. Extended till 2013 by decision of OCW in October 2011. Book editorship Aps, J.K.M., Allard, R.H.B., Duyck, J., Fokkema, S.J., Jacobs, R. & Vissink, A. (Eds.). (2012). Het tandheelkundig jaar 2012. Houten: Bohn Stafleu van Loghum. Aps, J.K.M., Brand, H.S., Duyck, J., Es, R.J.J. van, Jacobs, R. & Vissink, A. (Eds.). (2012). Het tandheelkundig jaar 2013. Houten: Bohn Stafleu van Loghum. Brand, H.S., Diermen, D.E. van & Makkes, P.C. (Eds.). (2012). Algemene ziekteleer voor tandartsen. ‐ 3e dr. Houten: Bohn Stafleu van Loghum. Membership of international editorial boards Bloemena, E.: Bloemena, E.: Bloemena, E.: Bolscher, J.G.M.: Bonifacio, C.C.: Cate, J.M. ten: Cate, J.M. ten: Cate, J.M. ten: Cate, J.M. ten: Cate, J.M. ten: Cate, J.M. ten: Crielaard, W.: 34 ISRN Gastroenterology. Scandinavian Journal of Gastroenterology. World Journal of Gastrointestinal Oncology. Chiang Mai University Journal of Natural Sciences. APCD journal. Chinese Journal of Dental Research. European Journal of Oral Sciences. International Journal of Dentistry. Journal of Dental Research. Journal of Oral Microbiology. Odontology. Microbiology ‐ SGM. Academic Centre for Dentistry Amsterdam
Gorter, R.C.: Jongh, A. de: Jongh, A. de: Loos, B.G.: Loos, B.G.: Loos, B.G.: Raber‐Durlacher, J.E.: Raber‐Durlacher, J.E.: Raber‐Durlacher, J.E.: Schoonheim‐Klein, M.E.: Shemesh, H.: Slot, D.E.: Veerman, E.C.I.: Velden, U. van der: Waal, I. van der: Waal, I. van der: Waal, I. van der: Waal, I. van der: Waal, I. van der: Waal, I. van der: Waal, I. van der: Waal, I. van der: Waal, I. van der: Weijden, G.A. van der: Wesselink, P.R.: Wesselink, P.R.: Wesselink, P.R.: Wesselink, P.R.: Zaura, E.: European Journal of Dental Education. European Journal of Psychotraumatology. Journal of EMDR Practice and Research. Journal of Clinical Periodontology. Journal of Dental Research. Oral Health and Preventive Dentistry. Mediterranean Oncology Journal. Supportive Care in Cancer. Mediators of Inflammation, special issue Alimentary Mucositis: Mediators, Mechanisms and emerging therapies. European Journal of Dental Education. Journal of Endodontics. International Journal of Dental Hygiene. Odontology. Journal of Clinical Periodontology. Acta Stomatologica Croatica. European Journal of Cancer. Journal of Dentistry University of Sao Paolo. Journal of Oral and Maxillofacial Surgery. Medicina Oral. Minerva Stomatologica. Oral Health and Preventive Dentistry. Oral Oncology. Padjadjaran Journal of Dentistry. International Journal of Dental Hygiene. Deutsche Zahnärztliche Zeitschrift. Endodontic Practice Today. Endodontie. International Endodontic Journal. Caries Research. Invited speakers at international congresses or symposia Aartman, I.H.A. (2012, May 04). Development and maintenance of dental anxiety. Goteborg, Sweden, The first symposium on behavioral and community dentistry. Bikker, F.J. (2012, January 10). A novel peptide substrate based approach to detect P. gingivalis enzyme activity in situ. London, UK, FP7 Persal application meeting, Dental Institute Kings College Guys Hospital. Bloemena, E. (2012, May 24). Pathological examination of the sentinel node. Amsterdam, the Netherlands, 5th International symposium on Sentinel Node Biopsy in Head and Neck Cancer. Brand, H.S. (2012, August 24). Saliva and wound healing. Beijing, China, International symposium Saliva and oral health. Cate, J.M. ten (2012, September 24). Capita selecta in cariology. Port Sunlight, UK, Unilever Expert Panel. Cate, J.M. ten (2012, February 14). Diversity in dental biofilms. Chicago, USA, MARS. Cate, J.M. ten (2012, April 17). Fluoride and biofilms. Weybridge, UK, GSK. Cate, J.M. ten (2012, October 16). Fluorides in caries prevention. Chengu, China, West China School of Stomatology. Cate, J.M. ten (2012, September 14). How tooth structure and its associated biofilms are modified by age, erosion and attritional wear. Helsinki, Finland, Symposium IADR PER. Cate, J.M. ten (2012, September 06). Remineralization through biofilms. Chicago, USA, Wrigley Oral Care. Cate, J.M. ten (2012, December 13). The dental plaque biofilm, a new target for prevention of oral diseases. Yoksuka, Japan, Kanagawa Dental College. Cate, J.M. ten (2012, October 15). The dental plaque biofilm, a new target for prevention of oral diseases. Chengu, China, West China School of Stomatology. Cate, J.M. ten (2012, December 12). The dental plaque biofilm, a new target for prevention of oral diseases. Kyoto, Japan, Shofy Company. Cate, J.M. ten (2012, January 05). The numerous microbial species in oral biofilms: how could antibacterial therapy be effective? Vina del Mar, Chile, ICNARA2. 35 Annual Research Report 2012
Crielaard, W. (2012, June 07). New insights into the complexity of microbiological infections in periodontitis. Vienna, Austria, EuroPerio7. Krom, B.P. (2012, June 11). Chemical and physical interactions between Candida and Pseudomonas. Berlin, Germany, 18th Congress of the International Society for Human and Animal Mycology. Laine, M.L. (2012, November 14). Bakteerit ja ihmissolut: parodontiumin kamppailuasetelma. Helsinki, Finland, Finnish Dental Congress. Laine, M.L. (2012, November 26). Modeling periodontitis with results from genotyping and microbiological analysis. Aarhus, Denmark, School of Dentistry, Aarhus University. Laine, M.L. (2012, June 06). Periodontitis as multifactorial disease. Vienna, Austria, European Federation of Periodontology (EFP), EuroPerio VII. Loos, B.G. (2012, June 06). Genetic predisposition for periodontitis and cardiovascular disease. Vienna, Austria, European Federation of Periodontology (EFP), EuroPerio VII. Loos, B.G. (2012, November 16). Modern periodontology: genetic and immunologic aspects of susceptibility to periodontitis. Moskou, Russia, X Congress CIS of Dentists “Innovations in dentistry”. Loos, B.G. (2012, November 27). New causality models for periodontitis. Aarhus, Denmark, Workshop Gene‐
environment interactions, School of Dentistry, Aarhus University. Raber‐Durlacher, J.E. (2012, May 19). 1. Stomatitis related to mTOR inhibitor targeted therapy. 2. Periodontal considerations in cancer patients. Athens, Greece, Hellenic Association of Supportive Care of the Oral Cavity in Cancer. Raber‐Durlacher, J.E. (2012, October 18). Periodontal considerations in cancer patients. Tel Aviv, Israel, International Meeting of the Israeli Society of Oral Medicine Team Approach to Oral Oncology‐The Key to Success. Rosema, N.A.M. (2012, June 20). Plaque removing efficacy of new and used manual toothbrushes. Iguacu Falls, International Association for Dental Research (IADR). Rosema, N.A.M. (2012, June 08). Toothbrushes to improve gingival health‐ what advances have been made? Vienna, Austria, Euro Perio. Shemesh, H. (2012, November 23). Dentinal defects on the root canal wall. Vilnius, Baltic Endo. Shemesh, H. (2012, April 15). Influence of endodontic procedures on the root canal walls. Boston, USA, American Association of Endodontics (AAE) – annual session. Shemesh, H. (2012, September 12). Post graduate endodontic programme in Amsterdam, 20 years perspective. Paris, France, Diderot University. Slot, D.E. (2012, June 07). 1. Do lasers / photodynamic therapy have a role in periodontal treatment? 2. Dental implants hygiene at home – what can patients do? Vienna, Austria, Euro Perio. Slot, D.E. (2012, May 10). 1. Finding evidence for evidence based decision making. 2. Oral halitosis. Rome, Italy, SISIO. Slot, D.E. (2012, December 15). Do lasers/photodynamic therapy have a role in non surgical periodontal treatment? Pisa, Italy, 1st National Congress on Research in Dental Hygiene. Slot, D.E. (2012, November 19). Interdental cleaning with an evidence based approach. Mexico City, UNAM. Slot, D.E. (2012, May 11). Interdental cleaning with an evidence based approach. Rome, Italy, Universita di Roma, Tor Vergata. Slot, D.E. (2012, March 18). Systematic reviews of efficacy and safety of oral hygiene tools. Antwerpen, Belgium, Verbond Vlaamse Tandartsen. Strijp, A.J.P. van (2012, March 15). Caries Management. Modern concepts in cariology. Managua, Nicaragua, Universidad Americana. Veen, M.H. van der (2012, November 25). Caries prevention. Recife, Brasil, Symposium Odontoprev. Veen, M.H. van der (2012, June 25). New technologies for diagnostics of dental caries. Rio de Janeiro, Brasil, Amil Dentistas. Velden, U. van der (2012, June 09). The nutritional approach of periodontitis. Vienna, Austria, European Federation of Periodontology (EFP), EuroPerio VII. Waal, I. van der (2012, November 15). Are we able to reduce the mortality and morbidity of oral cancer. Bilbao, Spain, IV International Symposium "Advances in Oral Cancer" Universidad del País Vasco. Waal, I. van der (2012, August 15). Clinicopathologic case presentations (2 cases). Oslo, Norway, 41st Annual Meeting SFOPOM (Scandinavian Fellowship for Oral Pathology and Oral Medicine). Waal, I. van der (2012, September 13). Introduction: terminology and classification. Athens, Greece, 11th Biennial congress of the European Association of Oral Medicine (EAOM), entitled: Potentially malignant disorders: new concepts and future prospects in diagnosis and management. 36 Academic Centre for Dentistry Amsterdam
Waal, I. van der (2012, February 17). The non‐squamous cell oral cancers. Granada, Spain, Spanish Society of Oral Medicine. Weijden, G.A. van der (2012, June 07). 1. Interdental oral hygiene, the evidence. 2. Mouthrinse, the evidence. Vienna, Austria, European Federation of Periodontology (EFP), EuroPerio VII. Weijden, G.A. van der (2012, November 02). 1. Interdental oral hygiene, the evidence. 2. Safety and efficacy of power toothbrushes. Cape Town, SADA2012. Weijden, G.A. van der (2012, February 06). 1. Periodontal risk assessment in practice. 2. Safety and efficacy of power toothbrushes. Manilla, Phillipines. Weijden, G.A. van der (2012, September 24). 1. Pinkesthetics. 2. Antibiotics in periodontal therapy. Ibiza, Intercongres. Weijden, G.A. van der (2012, July 06). Interdental oral hygiene, the evidence. Stuttgart, Germany, Summer‐
Academy ZFZ. Weijden, G.A. van der (2012, March 05). Safety and efficacy of power toothbrushes. Frankfurt, Germany, Key Opinion Leader event. Wesselink, P.R. (2012, September 12). (Re) treat or not. Paris, France, Post‐graduate programme symposium Paris‐ Diderot University. Wesselink, P.R. (2012, November 10). Regeneration bei apikaler Parodontitis – Möglichkeiten und Grenzen der endodontischen Therapie. Frankfurt, Germany, Deutsche Geselschaft für Zahn‐, Mund‐ und Kieferheilkunde, (DGZMK). Wesselink, P.R. (2012, November 15). Retreatment in the era of implants and adhesive dentistry. Moscow, Russia, Russian Dental Association. Wesselink, P.R. (2012, August 30). The implementation of virtual reality on dental education. Lyon, France, Association of dental education of Europe (ADEE). Wesselink, P.R. (2012, November 03). The implementation of virtual reality on dental education. Hongkong, China, South East Asian association for dental eduction ( SEAADE). Wesselink, P.R. (2012, August 17). The role of CBCT on treatment planning and outcome in endodontics. Sonoma, CA, USA, College of diplomates American Association of Endodontists (AAE). Wesselink, P.R. (2012, June 29). Tips and tricks for successful endodontics. Regensburg, Germany, Oberpfalzer Zahnarztetag. Wesselink, P.R. (2012, June 15). 1. What have we achieved the last 20 years. 2. What will we achieve the coming 20 years. Berlin, Germany, 25 Jahre Endodontie, Quintessenz Symposium. Zaura, E. (2012, January 04). New approaches to understanding the oral microbiome. Vina del Mar, Chile, International Conference on Novel Anticaries and Remineralizing agents ICNARA2. Membership academies Cate, J.M. ten (2008, January 01 ‐ 2013, December 31). Academy professor. Royal Netherlands Academy of Arts and Sciences (KNAW). Scientific awards/honours Bizzarro, S., Nicu, E.A., Velden, U. van der, Laine, M.L. & Loos, B.G. (2012, November 22). 1st Prize with article “Serum immunoglobulin g (IgG) levels against two periodontal pathogens and prothrombotic state”. Thrombosis Journal (2010);8:16, 1‐6. Dutch Society of Periodontology OralB Research Prize: Utrecht, the Netherlands. Cate, J.M. ten (2012, February 01). Honorary professor. West China School of Stomatology. Crielaard, W. (2012, February 01). Honorary professor Oral Biosciences. Department of Oral Biosciences, Faculty of Dentistry: University of Hong Kong, China. Galassi, F., Kaman, W.E., Anssari Moin, D., Horst, J. van der, Wismeijer, D., Crielaard, W., Laine, M.L., Veerman, E.C.I., Bikker, F.J. & Loos, B.G. (2012). 2nd Prize for Graduate Research with article “Comparing culture, real‐time PCR and fluorescence resonance energy transfer technology for detection of Porphyromonas gingivalis in patients with or without peri‐implant infections”. Journal of Periodontal Research 2012; 47. EFP 2012, awarded by dr. Stefan Renvert, EFP secretary general March 2013. Gorter, R.C. (2012, August 31). ADEE Award for excellence in dental education. Association for Dental Education in Europe (ADEE): Lyon, France. Kuzmanova, D., Jansen, I.D.C., Schoenmaker, T., Nazmi, K., Teeuw, W.J., Bizzarro, S., Loos, B.G. & Velden, U. van der (2012). 3rd Prize for Graduate Research with article “Vitamin C in plasma and leucocytes in relation 37 Annual Research Report 2012
to periodontitis”. Journal of Clinical Periodontology 2012; 39. EFP 2012, awarded by dr. Stefan Renvert, EFP secretary general March 2013 . Matse, J.H. (2012, February 05). Rene Vogels Scientific awards/honours. Utrecht, the Netherlands. Schaefer, A.S., Bochenek, G., Manke, T., Nothnagel, M., Graetz, C., Thien, A., Jockel‐Schneider, Y., Harks, I., Staufenbiel, I., Wijmenga, C., Eberhardt, J., Guzeldemir, E., Cine, N., Folwaczny, M., Noack, B., Meyle, J., Eikholz, P., Trombelli, L., Scapoli, C., Nohutcu, R., Bruckmann, C., Doerfer, C., Jepsen, S., Loos, B.G. & Schreiber, S. First Prize with article "Validation of reported genetic risk factors for periodontitis in a large‐
scale replication study”. EFP‐Jaccard Research Prize 2012, European Federation of Periodontology Congres: Vienna, Austria. Schilder, I. & Hunnik, M. van (2012, May 12). NT‐GSK Bachelorscriptie award 2012. Melding en preventie van prikaccidenten. Talking Points in Dentistry: Zeist, the Netherlands. Waal, I. van der (2012, August 17). Honorary member. Scandinavian Society for oral pathology and oral medicine (SFOPOM),: Oslo, Norway. Organisation of international congresses and symposia Bikker, F.J., Veldhuizen, E. & Haagsman, H.P. (2012). 5th Annual Symposium on Host Defence Peptides. Cate, J.M. ten (2012, January 02). Organizing committee. International Conference on Novel Anticaries and Remineralizing agents ICNARA2: Chile. Soet, J.J. de & Morsen, W.V.A. (2012, March 06). Organizing committee. Harmonising dental infection prevention guidelines in Europe, AESIC meeting: Amsterdam, the Netherlands. Other international functions Allard, R.H.B.: National association ITrepresentative International Association of Oral and Maxillofacial Surgery. Bolscher, J.G.M.: Co‐investigator of research project on the "Inhibition of Burkholderia pseudomallei biofilm formation by the Lactoferrin peptide LFchimera. Principal Investigator: prof.dr. S.Taweechaisupapong Department of Oral Diagnosis, Khon Kaen University, Thailand. Brandt, B.W.: Invited opponent at thesis defense Departamento de Tecnologías del Medio Ambiente, Universidad de Cádiz. Cate, J.M. ten: Honorary professor Universidad Peruana Cayetano Heredia, Lima, Peru. Cate, J.M. ten: Honorary professor University of Hong Kong, China. Cate, J.M. ten: Member advisory panel Wrigley Science Institute, Chicago, USA. Crielaard, W.: Visiting professor Oral Microbiology award. School of Stomatology, Sun Yat Sen University: Guangzhou, China, (2012, February 02). Krom, B.P.: Reviewer Atip‐Avenir Programme, April, France. Laine, M.L.: Opponent of G. Dabija‐Wolter with the PhD thesis “Interactions between Fusobacterium nucleatum and primary human oral cells”, June 2012 University of Bergen, Norway. Laine, M.L.: Opponent of M. Hernandez with the PhD thesis “Identification of collagenolytic MMP networks potential biomarkers in progressive chronic periodontitis subjecs and MMP‐8 null allele model“, January 2012 University of Helsinki, Finland. Loos, B.G.: Invited expert at the IXth European Workshop in Periodontology. Theme: 1st Joint EFP/AAP workshop on periodontal and systemic diseases EFP (European Federation of Periodontology) and AAP (American Academy of Periodontology), La Granja, Madrid, Spain. Loos, B.G.: Opponent of M. Yakob with the PhD thesis “Associations between oral biofilm, periodontal disease, and systemic health; with focus on atherosclerosis and breast cancer", February 13, 2012 Karolinska Institute of Odontology and University of Helsinki, Faculty of Medicine, Stockholm, Sweden. Raber‐Durlacher, J.E.: Expert reviewer information summary about oral complications in cancer Contribution to NCI PDQ (National Cancer Institute Physician Data Query). Raber‐Durlacher, J.E.: Editorial consultant Mediterranean Oncology Journal. Raber‐Durlacher, J.E.: Board member Multinational Association for Supportive Care in Cancer (MASCC). Schoonheim‐Klein, M.E.: Chair Advisory committee the excellence in Dental Education Advisory Committee (EDEAC). 38 Academic Centre for Dentistry Amsterdam
Schoonheim‐Klein, M.E.: External examiner Dental School, Trinity College, Dublin, Ireland. Shemesh, H.: Country representative European Society of Endodontology, General assembly meeting, Barcelona, Spain. Soet, J.J. de: Membership secretary and webmaster European Organization for Caries Research (ORCA). Veen, M.H. van der: Past president Diagnostic Sciences Group, International Association for Dental Research (IADR). Veen, M.H. van der: Secretary general European Organization for Caries Research (ORCA). Veen, M.H. van der: Honorary lecturer University of Liverpool, UK. Velden, U. van der: Chairman postgraduate education committee European Federation of Periodontology (EFP). Velden, U. van der: Executive board member European Federation of Periodontology (EFP). External examiner PGs of EFP Graduate programs in periodontology, 2012 April: Velden, U. van der: Paris, June: Straatsburg and Leuven. Waal, I. van der: Register of external evaluation experts Hellenic Quality Assurance Agency for Higher Education (HQAA). Waal, I. van der: Member scientific committee STOMA. Weijden, G.A. van der: Board member Advisory board DentalCare.com. Weijden, G.A. van der: Board member EMEA Oral Health Advisory Council. Supervisor of an external PhD student Krom, B.P.: Supervisor of external PhD student Jarosz with thesis: "Molecular unraveling of interspecies crosstalk". Supervisor: Prof.dr. H.C. van der Mei University Medical Center Groningen, the Netherlands, 2012, February 01. Societal impact Oral infections, in particular caries, root canal infections and periodontal diseases, have a substantial impact on the society. They are the most frequent infections in the western society and have important consequences, both medically and economically. The general aim of the program is to understand the normal healthy oral cavity and thus to better understand the causes and circumstances of the oral infections, to investigate preventive measures, and to develop treatment strategies. The program also contains research projects on oral cancer and precancerous lesions. In addition, attention is paid to social and psychological aspects of dental treatment, such as dental anxiety, a condition which, if not treated properly, automatically develops into a self‐reinforcing spiral of negative thoughts, avoidance, tooth decay, oral infections, and pain. We are currently investigating the effectiveness of a range of treatment methods to alleviate people’s fear and anxiety responses and to improve quality of life. We focus on measuring the patient’s perception and valuation of their oral health, since evidently these are major drivers of oral health care consumption. Through education, a new generation of dentists and researchers in the Netherlands, Europe and the world are trained to implement a radical shift from mechanistically and (invasive) treatment oriented professionals to 21st century oral physicians focused on diagnosis and prevention of dental and of oral infections and maintenance of the quality of life. Over the last 5 years it has become increasingly clear that oral infections are having negative impact on cardiovascular health, diabetic status and quality of life. The researchers in this theme focus on this aspect. The members of our priority area have had a relative large number of invitations to give lectures at dental congresses, and to educate the dental profession on fundamental understanding of oral health. Moreover, we experienced increased interest from newspapers, magazines and radio programs on the above subjects, in which we participated. The link oral health ‐ general health is actively communicated by the researchers. Interestingly, the Dutch Dental Association has announced this link as their anniversary theme for 2014. Important for the dental profession and the general public, is the substantial number of published and accessible systematic reviews (and meta‐analyses) on the various modes of prevention and oral hygiene measures. These contribute to clinical protocols for the dental profession and form the basis for evidence based dentistry. 39 Annual Research Report 2012
Ongoing clinical research on oral and head/neck cancer contributes to improved prevention, diagnosis and treatment of relevant patient groups. New plans are developed to bring together knowledge on oral microbiomes and salivary innate immune peptides with oral cancer diagnosis and pathophysiology. Our finding that salivary peptides promote wound healing has attracted much attention and interest from industry to apply these peptides, which have been patented by us, for healing of chronic wound and skin burns. The role of saliva as a medium for non‐invasive diagnostics is internationally a “hot topic”. The program has strong links with all players in the oral care industry; this not only results in “contract research”, but also in industrial co‐funding of grants (STW) and has led to participation of ACTA in the Top Institute Food and Nutrition (TIFN), where the theme “Oral Health” has been initiated. In this theme, world players in the oral care industry, the chewing gum industry, flavour industry, food industry and (oral) care appliances industry collaborate with the University of Wageningen, TNO and ACTA. The burden of dental caries in young Lao children is high. As a result, these children suffer from toothache, and school absenteeism is very common. ACTA researchers helped to develop strategies on dental health care. Likewise, ACTA researchers evaluated the gingival health in young children in Birma, who participated in a school‐based toothbrushing programme. Also sodium fluoride toothpaste were collected in various countries and the fluoride content was assessed. All samples from the Netherlands complied with ISO labelling requirements and there were no differences between the fluoride content declared and that found to be present on analysis. In samples purchased in various other countries, sodium monofluorophosphate toothpastes predominantly showed a low percentage of free available fluoride and the majority of toothpastes did not follow standard labeling guidelines. These results have big societal impact beyond The Netherlands and contribute to our role in helping developing countries. Interactions and collaborations with the industry and other non‐university groups Several collaborations exist with the industry, evident from grants obtained over the years from among others Philips, Proctor & Gamble, Gaba (Colgate); see the list of current grants in the paragraph of indicators of esteem above. In addition the following interactions can be mentioned: Crielaard, W. (2012, 12‐13 June).Mars Technical Committee, Waltham on the Wolds, England, UK. As part of TIFN interactions with Wrigley, GlaxoSmithKline, Philips Research & Cargill. Shemesh, H. In relation to the STW project with Satelec, ACTEON group, Merignac, France. In addition the following advisory functions can be mentioned: Cate, J.M. ten; Wrigley Science Institute, member Advisory panel, 2010‐2013. Loveren, C. van; Advisory function for the Dutch Consumers Organization and the Dutch Dental Association about free dental care fees. Interactions with the general public Several scientists had interviews with the Dutch general press in journals, radio and television or wrote papers for the general public. More details are listed below. Eijkman, M.A.J; Four articles for the general public in the Dutch newspaper NRC (see also the paragraph on Publications for the general public) Jongh, A. de; One article for the general public in Folia Magazine. Strijp, A.J.P. van; Zo zorg je voor een stralende lach zonder gaatjes. Interview J/M Ouders. Impact of the research on professionals Patients are referred by their dentists to the various specialized clinics of the departments participating in the program for diagnosis and treatment based on the latest scientific evidence. The guidelines for patient treatment related to the sub‐programme Oral and Maxillofacial Surgery were adopted by the Dutch Society for Oral and Maxillofacial Surgery. Several scientists of the program had interviews in Dutch dental Journals. A total of 95 professional publications were written. In addition, the following items can be mentioned: Krom B.P. (2012, August) Interview Nederlands Tijdschrift voor Wondzorg, nr. 8: 10‐11, NTVW. Schuller, A.A., Kempen, C.P.F. van, Verrips, G.H.W. (2012).Web‐based voorlichtingsfilm over mondzorg. JGZ.12 oz bw. Indd, 35‐38. Shemesh, H. Richtlijn gebruik van CBCT in tandheelkunde, Endodontologie – NMT. Strijp, A.J.P. van (2012, September 21). “Niets is zo moeilijk als gedragsverandering”. Dental Tribune Strijp, A.J.P. van Co‐author syllabus NMT Nascholingsprogramma IQual: Kindertandheelkunde. Risico‐
inschatting. 40 Academic Centre for Dentistry Amsterdam
Waal, I. van der (2012). Mondbranden. Alles over het gebit. Contribution for NMT patiëntenplatform. Warnsinck, C.J. Richtlijn aangezicht pijn – Nederlandse Vereniging voor Endodontologie (NVvE), Amsterdam, the Netherlands. Weijden, G.A. van der (March 2012). “Nazorg van implantaten”, College van adviserend tandartsen, Zeist, the Netherlands. Weijden, G.A. van der; (2012, January). Schuine borstelharen verwijderen meer plaque. Interview Nederlands Tandartsenblad. Organisation of national congresses and symposia Gorter, R.C. (2012, March 22). Heerlijk helder. Wordt kwaliteit transparent? Nederlandsch Tandheelkundig Genootschap, Amsterdam, the Netherlands. Jongh, A. de Organizer 5 symposia. Shemesh, H. Lustrum congress Nederlandse Vereniging voor Endodontologie (NVvE), Amsterdam, the Netherlands. Slot, D.E. (2012, 27‐29 September). NVM lustrum congres (M)Haastricht in Flow, the Netherlands. Strijp, A.J.P. van (2012, November 16). Co‐organizer ACTA/Kuraray symposium Restauratieve Tandheelkunde. Memberships of national editorial boards Brand, H.S.: Nederlands Tijdschrift voor Tandheelkunde. Loveren, C. van: Nederlands Tijdschrift voor Tandheelkunde. Waal, I. van der: Nederlands Tijdschrift voor Geneeskunde. Other national functions More than 25 memberships of national committees and advisory councils can be mentioned. The following scientists were members of these committees: Allard, R.H.B., Bloemena, E., Loos, B.G., van Loveren, C., Shemesh, H., de Soet, J.J., van Strijp, A.J.P., Veerman, van der Velden, U., E.C.I., van der Waal, I , van der Waal, S.V., Wesselink, P.R., Wu, M.K. Invited speakers at national congresses or symposia More than 65 presentations were given for professionals at congresses and symposia in the Netherlands by the following scientists: Allard, R.H.B., Bikker, F.J., Bloemena, E., Brand, H.S., Crielaard, W., ten Cate J.M., Krom, B.P., Laine, M.L., Loos, B.G., van Loveren, C., Shemesh, H., de Soet, J.J., van Strijp, A.J.P., Teeuw, W.J., Veerman, E.C.I., van der Velden, U., van der Waal, I , van der Waal, S.V., Warnsinck, J., Wesselink, P.R., van der Weijden, G.A., Wu, M.K., Zaura, E. Courses organised for dental and medical professionals Scientists of the program participated in courses in the Netherlands for dentists and oral hygienists. A total of 13 courses were given in the Netherlands for dentists, medical specialists and oral hygienists. Brand, H.S., van Diermen, D.E., Gorter, R.C., Hoogenkamp, M.A., Loos, B.G., Shemesh, H., van Strijp, A.J.P., van der Veen, M.H., van der Waal, I., Wesselink, P.R., van der Weijden, G.A., Zaura, E. Lectures during courses for dental and medical professionals in the Netherlands More than 45 lectures were given during courses for dentists, medical specialists and oral hygienists in the Netherlands. Bloemena, E., Brand, H.S., Crielaard, W., ten Cate J.M., van Diermen, D.E., Gorter, R.C., de Jongh, A., Krom, B.P., Laine, M.L., Loos, B.G., Shemesh, H., van Strijp, A.J.P., Teeuw, W.J., van der Waal, I , Wesselink, P.R., van der Weijden, G.A., Zaura, E. Collaborations -
Advisory board DentalCare.com. AMC Research Landsteiner Laboratory, Academic Medical Center, Amsterdam, the Netherlands. AMC, Department of Biomedical Opticals, Amsterdam, the Netherlands. AMC, Department of Electron Microscopy, Amsterdam, the Netherlands. 41 Annual Research Report 2012
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42 AMC: Dept. of microscopy: dr. J. Stap. Bambodino Kinderpraktijk, dr. Gambon, Rotterdam, the Netherlands. Braun Oral Research (dr. P. Warren) Baltimore, USA. Charite University, Berlin, Germany. Charles Cobb, Department of Periodontics, School of Dentistry, University of Missouri‐Kansas City, USA. Christof Doerfer, Clinic for Conservative Dentistry and Periodontology, Uniklinikum Schleswig‐Holstein‐
Campus Kiel‐Germany. Department Medical Microbiology and Infection prevention, Vrije Universiteit, prof.dr. C.M.J.E. Vandenbroucke‐Grauls, Amsterdam, the Netherlands. Department of Clinical Epidemiology and Biostatistics, VUmc, Amsterdam, the Netherlands. Department of Clinical Genetics, VUmc, Amsterdam, the Netherlands. Department of Dentistry and Oral Hygiene and Department of Biomedical Engineering. Faculty of Medical sciences, University of Groningen, Groningen, the Netherlands. prof.dr. M.C.D.N.J.M. Huysmans. Department of Dermatology, Sint Antonius Ziekenhuis, Nieuwegein, the Netherlands. Department of ENT, Dental Ophthalmological, and Cervicofacial Sciences, University of Parma, Unit of Oral Pathology and Medicine, section of Odontostomatology, Parma, Italy. Department of Health Sciences, Kristianstad University, prof.dr. S. Renvert, Kristianstad, Sweden. Department of Informatics, VU University Medical Center, Amsterdam, the Netherlands. Department of Medical Microbiology and National Reference Center for Systemic Mycoses, University Medical Center Göttingen, Göttingen, Germany. Department of MicroArrayFacility, dr. T. Breit, Universiteit van Amsterdam, the Netherlands. Department of Microbiology, Ghent University, Dr.. S. van trappen and prof.dr. P. de Vos. Department of Oral and Maxillofacial Surgery and Maxillofacila Prosthetics, University of Groningen, prof.dr. B. Stegenga, Groningen, the Netherlands. Department of Oral and Maxillofacial Surgery, Leids Universitair Medisch Centrum, Leiden. Department of Oral Medicine, Carolina Medical Center, Carolina, USA. Department of Oral Surgery, University of Porto, Porto, Portugal. Department of Otolaryngology/Head and Neck Surgery, VUmc, Amsterdam, the Netherlands. Department of Pediatric and Social Dentistry, São Paulo State University (UNESP), Araçatuba, Brazil. Department of Prosthodontics and Periodontology, Dental School of Piracicaba, State University of Campinas, SP, Brazil. Deutsche Krebsforschungszentrum Division of Molecular Genome Analysis, Heidelberg (dr. C. End). Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK. EMEA Oral Health Advisory Council. Erasmus MC, Department of Medical Microbiology and Infectious Diseases, mw. W.E. Kaman‐van Zanten, Willem van Wamel, Rotterdam, the Netherlands. Erasmus MC, Dept. of Biomedical Engineering, Rotterdam, the Netherlands. Erasmus Medisch Centrum. Medical Microbiology (prof.dr. A .van Belkum, dr. W. Wamel). Faculty of Veterinary Medicine, dr. H. Booij‐Vrieling, University of Utrecht, the Netherlands. Federal University of Paraiba, Joao Pessoa, Brazil. Gaba International Ltd. Therwil, Switzerland. GGZ‐regio Noord Holland Noord. Heerhugowaard (dr. D. Cohen). Global Dental Hygiene Advisory Board. Hebrew University‐Hadassh, dr. Davidovich, Jerusalem, Israel. Inspektor Research Systems BV, Amsterdam, the Netherlands. Institute of Computer Science, FORTH Vassilika Vouton, Heraklion, Greece, prof.dr. V. Moustakis. Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, MA, USA. Karim M. Fawzy El‐Sayed, Oral Medicine and Periodontology Department‐ Faculty of Dentistry‐ Cairo University‐ Egypt, Clinic for Conservative Dentistry and Periodontology, Uniklinikum Schleswig‐Holstein‐
Campus Kiel‐Germany. Khon Kaen University, Thailand. Dept. Oral Diagnosis (dr. S. Taweechaisupapong). Khon Kaen University, Thailand. Dept. Oral Diagnosis (dr. S. Taweechaisupapong). Kindertandheelkundepraktijk Bambodino. Rotterdam (dr. D. Gambon). Laboral Diagnostics CV, Houten, the Netherlands. Laboratoire de Sonochimie des Fluides Complexes; Institut de Chimie Séparative de Marcoule, France. Academic Centre for Dentistry Amsterdam
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Laboratory of Immunogenetics, Vrije Universiteit Medical Center, prof.dr. A.S. Peña, Amsterdam, the Netherlands. Leiden Universitair Medisch Centrum (dr. M.M. Welling). Ludwig Boltzmann Institut fur Osteologie (prof.dr. P. Fratzl) Vienna, Austria. LUMC kindergeneeskunde. Mahidol University, Bangkok, Thailand, Fac Science and Fac of Tropical Medicine (prof.dr. S. Sirisiha and dr. N. Chantratita). Mark Putt, Health Science Research Center, Indiana University‐Purdue University, Fort Wayne, IN, USA. Max Planck Institute for Chemical Ecology, Department of Bioorganic Chemistry, prof.dr. Axel Mithoefer, Jena, Germany. Max Planck institute, Dept. of intrfaces and colloids, Potsdam, Germany. Medical School, Prof. van Laar, Newcastle upon Tyne, U.K. Medisch Centrum Leeuwarden, dr. De Visscher, Leeuwarden, the Netherlands. MRC‐Holland BV, Amsterdam, the Netherlands. Netherlands Cancer Institute, Amsterdam, the Netherlands. NIZO, Ede, the Netherlands. NUTRIDENT consortium: (UCL Eastman Dental Institute), (University of Pavia), (University of Tel Aviv), (University of Genoa), (Goteborg University), (University of Verona), (Quest International), (Glycologic Ltd). Padjadjaran University, Dept. Periodontology (dr. S. Lambri), Bandung, Indonesia. Peking University School of Stomatology .Beijing, China. Peking University School of Stomatology. prof. Hong Hua, Beijing, China. Philips Research, the Netherlands. dr. B. Gottenbos. Prasanna Neelakantan, Saveetha Dental College and Hospitals, Saveetha University, Chennai, India. Rajiv Ghandhi University of health sciences Karnataka, Bangalore, India. Rapid Pathogen Screening (RPS), Sarasota, Florida, USA (dr. B. van Dine). Rijksuniversiteit Groningen, Afdeling Mondziekten en Kaakchirurgie (prof.dr. A. Vissink). Rode Kruisziekenhuis Beverwijk, Skin regeneration and woundhealing (prof.dr. E. Middelkoop, dr. B. Ulrich). Sanguin, Departments of Immunopathology (dr. D.Wouters) and Blood Cell Research (prof.dr. T. van den Berg). Sanquin: Department of Immunopathology: dr. D. Wouters. Sanquin; Phagocyte Laboratory; Department of Blood Cell Research. Sao Paulo State University, Araraquara, Brazil (dr. M.M. Belluci and dr. P. de Souza). Saxion University of Applied Sciences, Deventer, the Netherlands. State University of Campinas, Dental School of Piracicaba, SP, Brazil. Sunstar Inc. Oral Care H&D, Osaka, Japan. dr. T. Takatsuka. Sunstar Inc., Osaka, Japan. Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands. The Hebrew University, Hadassah School of Dental Medicine, Department of Pediatric Dentistry, Jerusalem, Israel (dr. E. Davidovich). TNO Quality of Life, Business Unit Food and Biotechnology Innovations, Microbial TNO, Genomics Group, Zeist, the Netherlands. Top Institute of Food and Nutrition (TIFN) project TNO, Zeist, the Netherlands. UAS, Faculty of Medicine, Hospital Pediatrico de Sinaloa, Mexico (dr. Nidia León Sicairos). UAS, Faculty of Medicine, Hospital Pediatrico de Sinaloa, Mexico (dr. Nidia León Sicairos). Unilever Research (dr. D.J. Page), Port Sunlight, United Kingdom. Unilever Research, Port Sunlight, UK. Univeristé Libre de Bruxelles, Brussels, Belgium. Universitair Medisch Centrum Utrecht, dr. Dijkema, Utrecht, the Netherlands. Universität Kiel (dr. P. Saftig) Kiel, Germany. Université Paris 6 ; Laboratoire d'Imagerie Paramétrique CNRS UMR 7623 Université Paris 6 15 rue de ‐
l'Ecole de Médecine F ‐ 75006 Paris, France. Universiteit of Utrecht. Medicinal Chemistry (dr. N. Martin). Universiteit Twente, Fluid dynamics Lab, Enschede, the Netherlands. Universiteit van Amsterdam, AMC, Celbiologie en Histologie (dr. J. van Marle). Universiteit van Amsterdam, AMC, Humane Retrovirologie (prof.dr. B. Berkhout). -
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43 Annual Research Report 2012
44 Universiteit van Amsterdam, Department of Molecular Microbial Physiology, Swammerdam Institute for Life Sciences, Faculty of Science,, Amsterdam, the Netherlands. Universiteit van Amsterdam, Klinische Chemie (prof.dr. A. Sturk, dr. R. Nieuwland), Amsterdam, NL. University College of London, Queen Mary's School of Medicine and Dentistry, prof.dr. M.Curtis, London. University Libre Bruxelles, Dept Biol & Med Chem & Pharmaceut Microbiol. Belgium (dr. J‐P. Dehaye). University Medical Center Göttingen, Department of Medical Microbiology and National Reference Center for Systemic Mycoses, Göttingen, Germany. University of Chiang Mai, Thailand, Dept of Odontology and Oral Pathology (dr. S. Krisanaprakornkit). University of Amsterdam (microarray department (mass spectrometry) (Biosystems data analysis), (microscopy department), (fungal microbiology), Amsterdam, the Netherlands. University of Amsterdam Centre for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, Amsterdam, the Netherlands. University of Amsterdam Microarray Department & Integrative Bioinformatics Unit, Faculty of Science, Amsterdam, the Netherlands. University of Amsterdam, Van 't Hoff Institute for Molecular Sciences, Amsterdam, the Netherlands. University of Aquila (Italy), Dept. of Biomedical Sciences and Technology (dr. A. Bozzi). University of Bath, Bath, United Kingdom. University of Birmingham, Dental School, Birmingham UK. University of Bonn, Dept. of Periodontology (prof.dr. S. Jepsen), Germany. University of Calgary, Calgary, Canada. Dept. of Biological Sciences (prof.dr. H.J. Vogel). University of Calgary, Calgary, Canada. Dept. of Biological Sciences (prof.dr. H.J. Vogel). University of California at Los Angeles. Dept. Oral Biology and Medicine (prof.dr. D.T. Wong) . University of California Los Angeles (UCLA), School of Dentistry, Los Angeles, CA, USA: dr. David T. Wong. University of Chiang Mai, Thailand, Dept of Odontology and Oral Pathology (dr. S. Krisanaprakornkit). University of Chile, Santiago, Institute of Biomedical Sciences (prof.dr. M. González). University of Dar es Salaam (MUCHS), Dar es Salaam, Tanzania. University of Dundee, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, UK. University of Goteborg, Sweden (dr. Niclas Karlsson). University of Gothenburg, Dept. of Oral Microbiology, prof.dr. G. Dahlén, Gothenburg, Sweden. University of Groningen, Department of Biomedical Engineering. University of Groningen, Faculty of Medical Sciences, Dept. of Dentistry. University of Kiel, Dept. of Gastro‐Enterology (prof.dr. S. Schreiber) Germany. University of Kiel, Institute for Clinical Molecular Biology, Kiel, Germany, dr. A. Scheafer. University of Liverpool, Liverpool, UK. University of Madrid, Centro di Investigaciones Biologicas (prof. dr. L. Rivas). University of Melbourne, Australia. University of Oporto, Portugal, Dept of Chemistry (dr. M. Bastos). University of Oporto, Portugal, Dept of Chemistry (dr. M. Bastos). University of Oslo, Dept. of Microbiology, prof.dr. I. Olson, Oslo, Norway. University of the Mediterranean, Marseille, France. University of Utrecht. Faculty of Veterinarian Medicine (prof.dr. H. Haagsman). University of Zurich, Switzerland, dept. of Endodontology, dr. Frank Paque. UNPAD in Bandung. Utrecht University, Department of Infectious Diseases and Immunology, prof.dr. H.P. Haagsman, Utrecht, the Netherlands. VU University Amsterdam, Department of Molecular Cell Physiology, the Netherlands. VUmc, Dermatologie (prof.dr. S. Gibbs, prof.dr. R. Schepers). VUmc, Medische Microbiologie (dr. B. Appelmelk). VUmc, Moleculaire Celbiologie en Immunogenetica, sectie Glycoimmunologie (dr. I. van Die). VUmc, Moleculaire Celbiologie en Immunogenetica, sectie Immunomodulatie (prof.dr. Y. van Kooyk). VUMC, Molecular Cell Biology and Immunology: dr. M.Boks. VUmc, Orthopedie (prof.dr.ir. T.H. Smit). VUMC. Dept. of Dermatology, professor S Gibbs. Wellington School of Medicine, Wellington, New Zealand. Whitehead Institute and MIT, Cambridge, MA, USA (prof.dr. H.L. Ploegh). Wim van Palenstein Helderman, Utrecht, the Netherlands. Academic Centre for Dentistry Amsterdam
Current PhD projects Arikan, M. Supervisor: prof.dr. W. Crielaard; co‐supervisor: dr. E. Zaura, start: December 2012. Bizzarro, S. The local and systemic effects of periodontal therapy modalities on risk biomarkers of cardiovascular disease. Supervisor prof.dr. B.G. Loos, start: June 2009. Benzian, H. The neglected state of global oral health‐ a roadmap for effective change. Supervisors: prof. dr. G.A. van der Weijden and prof. dr. W.H. van Palenstein Helderman, start: 2010. Boink, MA. Histatin peptides for treatment of chronic wounds. Supervisors: prof.dr. E.C.I. Veerman and prof.dr. S Gibbs; co‐supervisor: dr J.G.M. Bolscher, start: November 2010. Bonifacio, CC. The art of proximal gic restorations in primary teeth. Supervisor: prof.dr. C. van Loveren; co‐
supervisors: dr. W.E. van Amerongen and dr. C.J. Kleverlaan, start: September 2009. Bont, P de. Treatment of trauma in psychosis (TTIP)2. Supervisors: prof.dr. A. de Jongh and prof. A. van Minnen, start: 2011. Broers, D.L.M. Experienced‐based dentistry in individuals with physical and/or mental limitations. Supervisors: prof.dr. A. de Jonmgh and prof.dr. A.J. Feilzer, start: 2012. Brouns, EREA. Oral Leukoplakia; diagnosis and treatment. Supervisors: prof.dr. I. van der Waal and prof.dr. E. Bloemena, start: 2010. Cukkemane, N. Design of protective coatings against dental erosion for application in oral care products. Supervisors: prof.dr. E.C.I.Veerman; co‐supervisors: dr. F.J. Bikker and dr. H.S. Brand, start: December 2009. Dautovic, E. Effectiveness of EMDR among adults with PTSD and an intellectual dissability. Supervisors: prof.dr. A. de Jongh and prof.dr. F. Oort. Dekker, H. Peri‐implantitis, implant loss and osteoradionecrosis in oral cancer patients. Supervisors: prof.dr. E.A.J.M. Schulten, prof.dr. C.M. ten Bruggenkate and prof.dr. E. Bloemena; co‐supervisor: dr. N. Bravenboer, start: 2010. Dieleman, A. Characterization of saliva and the oral microflora in dry mouth patients. Supervisors: prof. dr. E.C.I Veerman; co‐supervisors: dr .H.S. Brand and dr .C.P. Bots, start: September 2011. Donders, HCM. The effects of periodontal therapy on systemic health of patients with cardiovascular disease. Supervisors: prof.dr. J. de Lange and prof.dr. B.G. Loos, start: January 2011. Dubois, L. Predictablility of orbital reconstruction. Supervisor: prof.dr. A.G. Becking, start: September 2011. Duijster, D. The prevention of early childhood caries of children at high risk. Supervisors: prof.dr. C. van Loveren & prof.dr. G.H.W. Verrips, start: September 2010. Dijk, IA van. How histatins enhances wound closure: structural and cellular aspects. Supervisor: prof.dr. E.C.I. Veerman; co‐supervisor: dr. J.G.M. Bolscher, start: February 2011. Elfrink, MEC. Deciduous molar hypomineralisation, its nature and nurture. Supervisors: prof.dr. J.M. ten Cate and prof.dr. H.A. Moll; co‐supervisor: dr. J.S.J. Veerkamp, start: 2008. Exterkate, RAM. Biofilm model for studying antimicrobial agents. Supervisors: prof.dr. J.M. ten Cate and prof.dr. W.Crielaard, start 2007. Fernandez y Mostajo, M. Novel methods for preventing and treating polymicrobial biofilm infections in the oral cavity. Supervisors: prof.dr. W. Crielaard, prof.dr. G.A. van der Weijden and prof.dr. W. Beertsen; co‐
supervisor: dr. E. Zaura, start: June 2011. Geurs, NC. Socket preservation after extraction for implant dentistry. Supervisor prof.dr. B.G. Loos, start: 2010. Groot, M de. Skull growth in oncological treatments in childhood. Supervisor: prof.dr. L.E. Smeele, start: January 2013. Gunput, STG. The effect of saliva on the complement system. Supervisor: prof.dr. E.C.I. Veerman; co‐
supervisor: dr. A.J.M. Ligtenberg, start: January 2012. Hansenova Manaskova, S. Sortase as target for antimicrobial peptides. Supervisor: prof.dr. E.C.I. Veerman; co‐
supervisor: dr. F.J. Bikker, start: November 2010. Helmers, R. Hyperbaric oxygen therapy and micro vascularisation. Supervisor: prof.dr. J. de Lange, start: September 2011. Hertog, D. Treatment of ameloblastomas. Supervisor: prof.dr. I. van der Waal, start: September 2009. Houtem, CMMH van. ADRA2B polymorphism as a putative biomarker for the acquisition of anxiety based on inadequate storage of emotional memories. Supervisors: prof.dr. A de Jongh and prof.dr. W. Crielaard, start: September 2009. Imangaliyev, S. Novel strategies to promote oral health. Supervisor: prof.dr. W. Crielaard; co‐supervisor: dr. B.J.F. Keijser, start: September 2012. Irshad, M. Host‐pathopgen interactions in peri‐implant infections. Supervisor: prof.dr. W. Crielaard; co‐
supervisors: dr. M.L. Laine and dr. W.A. van der Reijden, start: January 2007. 45 Annual Research Report 2012
Janus, MM. Microbial interactions in oral biofilms. Supervisor: prof.dr. W. Crielaard; co‐supervisor: dr. B.P. Krom, start: June 2012. Jiang, LM. Insights into passive ultrasonic irrigation. Supervisor: prof.dr. P.R. Wesselink; co‐supervisors: dr. L.W.M. van der Sluis and dr. A.M. Versluis and dr. D.M. Deng, start: October 2007. Jong, BG. de Local and systemic antibody responses for maintaining gingival health. Supervisors: prof.dr. W. Crielaard and prof.dr. B.G. Loos; co‐supervisor: dr. M.C. van Zelm, start: April 2012. Jong‐Lenters, M de. Family, oral health, weight and growth. Supervisor: prof.dr. G.H.W. Verrips; co‐supervisor prof.dr. J. Hoogstraten, start: November 2010. Kaiwar, A. Supervisor: prof.dr. P.R. Wesselink; co‐supervisor: dr. H. Shemesh, start: 2012. Kaman‐van Zanten, WE. Highly specific bacterial proteolytic substrates for diagnostics in situ. Supervisor: prof.dr. H Verbrugh; co‐supervisors: dr. F.J. Bikker and dr. J. Hays, start: May 2009. Koopman, JE. Preventie van cariës in het melkgebit bij kinderen at risk. Supervisors: prof.dr. W. Crielaard and prof.dr. C. Van Loveren; co‐supervisors: dr. B.J.F. Keijser and dr. E. Zaura, start: April 2012. Kraneveld, EA. Understanding Candida proliferation mechanisms in elderly patients: characterization, prevention and treatment of imbalanced oral microbial communities. Supervisors: prof.dr. W. Crielaard and prof.dr. J.M. ten Cate, start: April 2007. Krikken, JB. Dental anxiety and behaviour management problems; the role of parents. Supervisor: prof.dr. J.M. ten Cate; co‐supervisors: dr. J.S.J. Veerkamp and dr. A.J. van Wijk, start: January 2005. Laheij, AMGA. Prospective study of changes in the oral biofilm and the protein composition of salivain patients, being irradiated for a tumour in the head‐and‐neck area. Supervisor: prof.dr. C. van Loveren; co‐
supervisor: dr. J.J. de Soet, start: December 2008. Leito, JTD. The role of salivary agglutinin and sthatherin in the defence against micro‐organisms. Supervisors: prof.dr. E.C.I. Veerman and prof.dr. A. van Nieuw Amerongen; co‐supervisor: dr. A.J.M. Ligtenberg, start: October 2005. Liang, Y‐H. The influence of the use of CBCT on endodontic outcome dtermination. Supervisor: prof.dr. P.R. Wesselink; co‐supervisors: dr. M.K. Wu and dr. H. Shemesh, start: 2010. Louropoulou, A. Maintenance of peri‐implant health, the evidence and guideline. Supervisor: prof.dr. G.A. van der Weijden, start: 2010. Macedo, RG de. Aspect of sodium hypochlorite as a root canal irrigant Supervisor: prof.dr. P.R. Wesselink; co‐
supervisor: dr. L.W.M van der Sluis, start: October 2010. Matse, JH. The diagnostic role of mucin expression in tissue and saliva in patients with salivary gland tumors. Supervisors: prof.dr. E. Bloemena and prof.dr. E.C.I. Veerman; co‐supervisor: dr. J.G.M. Bolscher, start: September 2008. May, A. Bioinformatic analysis for oral metagenomics. Supervisors: prof.dr. W. Crielaard and prof.dr. J. Heringa; co‐supervisors: dr. B.W. Brandt and dr. S. Abeln, start: August 2012. Metska, ME. Cone beam CT in endodontic diagnostic. Supervisor: prof.dr. P.R. Wesselink; co‐supervisor: dr. A.R. Özok, start: October 2009. Mevissen‐Renckens, EHM. PTSD in individuals with intellectual disabilities. Supervisors: prof.dr. A. de Jongh & prof. dr. R. Didden, start: 2010. Moghimi, M. Head and neck infections. Supervisor: dr. T. Forouzanfar, start: 2011. Moinzadeh, ATM. Quality assessment of root canal obturation. Supervisor: prof.dr. P.R. Wesselink; co‐
supervisor: dr. H. Shemesh, start: 2012. Neelakantan, P. Supervisor: prof.dr. P.R. Wesselink; co‐supervisor: dr. H. Shemesh, start: 2012. Papantonopoulos, GH. Mathematical modeling of periodontitis. Supervisor: prof.dr. B.G. Loos, ACTA, start: 2012. Persoon, IF. Molecular ecology and novel treatments in endodotic infections. Supervisors: prof.dr. W. Crielaard and prof.dr. P.R. Wesselink, start: 2010. Prodan, A. Saliva and oral health. Supervisors: prof. dr. E.C.I. Veerman; co‐supervisors: dr. H.S. Brand and dr. F.J. Bikker, start: September 2012. Ramawadh, RS. Molecular aspects of tissues around dental implants in oral oncology patients after radiotherapy. Supervisors: prof.dr. E. Bloemena, prof.dr. E.A.J.M. Schulten and prof.dr. C.M. ten Bruggenkate; co‐supervisor: dr. N. Bravenboer, start: 2011. Roos de, C. Treatment of children following a potential traumatic incident. Supervisors: prof.dr. A. de Jongh and prof. dr. Emmelkamp, start 2008. Rosema, NAM. Toothbrushing efficacy. Supervisor: prof.dr. U. van der Velden, co‐supervisor: prof.dr. G.A. van der Weijden, ACTA, start: 2006. Scheerman, JFM. Supervisors: prof.dr. G.H.W. Verrips and prof.dr. C. Van Loveren, start: September 2012. 46 Academic Centre for Dentistry Amsterdam
Schreuder, WH. Treatment options in central giant cell granuloma. Supervisor: prof.dr. J. de Lange, start: January 2010. Sijbrandij, T. Application of antimicrobial peptides as anti‐warfare therapeutics. Supervisors: prof. dr. E.C.I. Veerman; co‐supervisors: dr. F.J. Bikker and dr. A.J.M. Ligtenberg,start: March 2010. Sleen van der, J. Dento‐alveolaire chirurgie. Supervisor: prof.dr. J. de Lange, start: April 2012. Slot, D.E. Chlorhexidine gels and dental lasers in the prevention and therapy of periodontal disease. Supervisor: prof.dr. U. van der Velden, co‐supervisor: prof.dr. G.A. van der Weijden, ACTA, start: 2010. Strydonck, DAC Van. Chlorhexidine and the control of plaque and gingivitis. Supervisor: prof.dr. U. van der Velden, co‐supervisor: prof.dr. G.A. van der Weijden, ACTA, start: 2001. Teeuw, WJ. Relationships between periodontitis an general health: focus on diabetes and cardiovasculair disease. Supervisor: prof.dr. B.G. Loos, start: October 2010. Tuk, JC. Anxiety and pain related to oral and maxillofacial surgery. Co‐supervisors: dr. J.A.H. Lindeboom and dr. A.J. van Wijk, start: September 2012. Veerbeek, HJ. Treatment of feelings of revenge. Supervisor: prof.dr. A. de Jongh; co‐supervisor: dr. M.M.J. Kunst, start :2012. Vermaire, JH. Optimizing oral health. Towards a tailored, effective and cost‐effective dental care. Supervisors: prof.dr. W.B.F. Brouwer and prof.dr. C. van Loveren; co‐supervisors: prof.dr. J. Hoogstraten and dr. J.H.G. Poorterman, start: januari 2005. Verstraaten, S. Quality of life aspects oral and maxillofacial surgical procedures. Co‐supervisors: dr. J.A.H. Lindeboom and dr. A.J. van Wijk, start: September 2012. Vleugel, B. van der Treatment of trauma in psychosis (TTIP)1. Supervisors: prof.dr. A. de Jongh &prof. M. van der Gaag, start :2011. Volgenant, CMC. Red fluorescence in dental plaque. Supervisor: prof.dr. J.M. ten Cate; co‐supervisor: dr.ir. M.H. van der Veen, start: 2010. Waal, SV. van der Novel strategies for endodontic treatments. Supervisors: prof.dr. P.R. Wesselink and prof.dr. W. Crielaard; co‐supervisor: dr. J.J. de Soet, start 2009. Weijers, M. The prognostic value of different parameters in surgically removed oral squamous cell carcinomas from the tongue and floor of the mouth. Supervisor: prof.dr. I. van der Waal, start: October 1998. Zande, MM. van der Digital dentistry in practice: On dentists’ interaction with technological transformation. Supervisor: prof.dr. D. Wismeijer; co‐supervisor: dr. R.C. Gorter, start: February 2012. Zecha, J.A.E.M. Effect van lage intensiteit laser behandeling (LLLT) op bestralingsmucositis van het mondslijmvlies. Supervisor: prof.dr. L.E. Smeele, start: January 2013. 47 Annual Research Report 2012
Oral Regenerative Medicine Contact Person Prof.dr. F. Lobbezoo Department of Oral Kinesiology ACTA Gustav Mahlerlaan 3004 1066 EA Amsterdam Tel: +31‐20‐5980412 E mail: F. Lobbezoo@acta.nl Full professors A.G. Becking H. van Beek C.M. ten Bruggenkate V. Everts A.J. Feilzer S. Gibbs J. Klein‐Nulend J. de Lange M. Naeije F.J.M. Roeters F.R. Rozema P.F. van der Stelt D.B. Tuinzing E.A.J.M. Schulten D. Wismeijer Introduction The human masticatory system has several important functions that determine an individual’s general health and well‐being, like biting, chewing, swallowing, talking, laughing, and yawning. Sometimes, patients are confronted with problems in performing these functions. This may have various causes. On the one hand, chemical and bacteriological factors may hamper a healthy functioning of the masticatory system by causing infection and inflammation. On the other hand, mechanical overloading as well as underloading or disuse of the constituent structures of the masticatory system (viz., teeth, bone, cartilage, muscles, and joints) may yield functional oromandibular impairments. The research of ACTA’s research program “Oral Regenerative Medicine” (ORM) focuses on regenerating damaged oral tissue by means of stem cell therapy or tissue engineering techniques, taking into account the mechanical threats for the masticatory system. Relevant clinical problems are used to guide the research aimed at developing novel solutions for these clinical problems. Groups that are involved in ORM‐ACTA are Oral Kinesiology (OKI), Oral Implantology and 48 Academic Centre for Dentistry Amsterdam
Prosthodontics (IMP), Dental Materials Sciences (DMS), Oral Cell Biology and Functional Anatomy (OCB/FA), Oral Radiology (ORA), Orthodontics (ORT), and Oral and Maxillofacial Surgery (OMS), both of the Academic Medical Center (AMC) and of the VU Medical Center (VUmc). The Interfaculty MOVE Research Institute has chosen “Regenerative Medicine” as one of its domains (i.e., a collaboration of researchers on a key topic). Likewise, ORM has been formulated as one of the two priority areas (“zwaartepunt”) of ACTA. As implied above, a healthy oral system is characterized not only by the absence of infection and/or inflammation of dental and periodontal tissues, but also by a healthy musculoskeletal system and oral mucosa. Musculoskeletal tissues (i.e., bone, cartilage, muscles, and joints) and mucosa (epithelium and underling connective tissue) can be damaged or even destroyed by, for example, mechanical overloading, disuse, or disease. In case of tissue loss, the replacement or regeneration of degenerating/degenerated cells, tissues, or organs is needed to restore or establish normal function (Mason A, Dunnill PA. A brief definition of regenerative medicine. Regen Med 2008;3(1):1‐5). ORM studies these processes both fundamental and translational in multidisciplinary settings, in which dentistry/oral medicine closely collaborates with medical disciplines like orthopaedics and neurology, both within and outside The Netherlands. The main objectives of ORM‐related research are: (1) to develop strategies to prevent degeneration of oral tissues and/or organs, and (2) to develop minimally invasive, regenerative treatment strategies when prevention fails and treatment is required. Both the prevention of degeneration and minimally invasive, regenerative treatments illustrate the ongoing shift from curing diseases to preventing them. Clearly, a focus on early diagnosis will play an important role in enabling this shift. Tissue regeneration is possible by means of guiding stem cells and differentiated cells to repair and regenerate damaged tissue with the aid of custom‐designed biomaterials (matrices), mechanical loading, and nutrients (viz., growth factors, hormones, and medication). Stem cells can be differentiated into bone, cartilage, muscle cells, and oral mucosa and it is the understanding of the interactions between these different cell types together with the impact of mechanical loading which is essential if optimal tissue regeneration is to be achieved in the future. Insight into tissue regeneration is obtained by comparing results from tissue culture and animal models to computer simulations of the motor system and to biomechanical research in clinical trials with patients. The outcome of all ORM’s research efforts will be an increased understanding of degenerating/degenerated oral tissues and an improved ability to replace or regenerate these tissues, thereby restoring oral function and thus oral health‐related quality of life. Research objectives Overview The research of ORM focuses on the effects of events that damage or even destroy oral tissue (e.g., tumor removal, trauma accidents), including the effects of mechanical overloading or underloading on the tissues of the masticatory system, on the resulting clinical problems, as well as on the solutions for these clinical problems. These events have detrimental consequences for the constituent structures of the masticatory system (viz., the teeth, the periodontal tissues, the alveolar bone, the skeletal bone, cartilage, the mucosa, and the jaw musculature). Tissue damage and breakdown can occur, which may in turn cause clinical signs and symptoms of the intra‐oral structures and/or of the maxillo‐mandibular structures. For example, patients may report to the clinic of the dentist, orthodontist, or oral and maxillofacial surgeon with symptoms like tooth wear, tooth mobility, tooth loss with or without bony defects, pain in the masticatory muscles or in the temporomandibular joints, or dysfunction of the musculoskeletal structures (e.g., a reduced maximal mouth opening). Hard to heal lesions may develop in the oral mucosa as a result from radiation/ chemotherapy after tumor removal, extensive tooth extraction, or trauma. All of these signs and symptoms may yield complaints of a reduction or even a loss of normal oral and mandibular functions. Apart from these physical complaints, comorbid factors like an impaired psychosocial functioning and a reduced oral health‐related quality of life are commonly found in patients with pain and dysfunction of the masticatory system as well. After a proper diagnostic procedure, the health care professionals involved in the care of these patients may indicate rehabilitation strategies with the aim to restore normal oral and mandibular functions, following the principles of evidence‐based dentistry. Treatment planning and rehabilitation Much research of ORM focuses on treatment planning and actual rehabilitation of impaired or lost oro‐
mandibular function. Two main approaches can be distinguished. First, fundamental studies are conducted to 49 Annual Research Report 2012
develop new techniques for application, after proper clinical testing, in patient populations. Noteworthy in this context are studies to: a) stimulate bone growth around dental implants and into bone defects; b) fabricate dental restorations using computer‐aided design and manufacturing (CAD/CAM); c) use tissue engineering and regenerative medicine techniques, focussing on the collagen network and adipose stem cells; and d) improve the microcirculation in patients undergoing, for example, radiotherapy for malignancies. Second, randomized clinical trials are performed to add to the evidence base of treatment modalities. In this context, systematic reviews and meta‐analyses are regularly performed. In addition, evidence‐based guidelines are developed for application in clinical practice. Results obtained in 2012 Loading and tissue damage  As it is generally thought that bacteria are a possible cause of peri‐implantitis we focussed on the detection of an alleged marker for pathogenic microbiota, the bacteria P. gingivalis. Using a wide variety of techniques we found that P. gingivalis was not as specific as thought in peri‐implantitis patients.  In a literature review on the general decontamination of diseased implant surfaces we concluded that the mechanical and chemical decontamination should be combined to create an optimal environment for tissue regeneration. One of our ideas when treating contaminated implant surfaces is to work with airflow and calcium phosphate powder enriched with BMP’s. We did a literature review on airflow abrasion and we concluded that this might prove to be an good approach.  We reviewed the use of heterodimeric BMPs in osteogenesis and concluded that they have more distinct signaling and bio‐functions than homodimeric BMP’s have. They are characterized by more a faster effect, can be used at lower concentration and have a higher efficiency than homodimeric BMPs. Consequently, heterodimeric BMPs bear promising application potential in inducing osteogenesis.  The BMP heterodimers BMP2/7 of 5‐150 ng/mL were shown to enhance osteoclastic CaP resorption to a similar level as the two homodimers but at a much lower concentration. Low‐concentration of BMP2/7 heterodimer may favor a rapid remodeling of bone and, thus, bear a promising potential in cytokine‐based tissue engineering.  Using CBCT we managed to distract STL files of single teeth which were printed into titanium. The teeth were extracted and using subtraction techniques we proved that the printed teeth had the same dimensions as the extracted teeth. The fit into the extraction sockets was perfect. This opens new possibilities to print dental implants that fit the patient’s individual situation.  Bonding to dentin is still a challenge, especially in difficult accessible areas like the root channel system. Some fundamental aspects and novel bonding procedures were investigated. Furthermore, the strength, and fatigue‐ and the bonding properties of zirconia were investigated. Zirconia can be used as restorative material for dental crowns and bridges, but it can be also an alternative for metal implants. Understanding the surface properties of zirconia is therefore ongoing research.  Bone loss at inflamed sites in i.e. periodontitis and Crohn´s disease is likely dependent on the inflamed state of peripheral blood, which contains both osteoclast precursors and inflammatory mediators such as T‐lymphocytes. We established that osteoclasts form only in the presence of monocytes and T‐
lymphocytes, and that more osteoclasts are formed from Crohn’s disease peripheral blood.  Osteoclasts are multinucleated cells that form through fusion of mononuclear precursors. Using time‐
lapse imaging we found that precursors fuse with each other or with existing multinucleated cells. We also found that osteoclasts split into separate syncitiae, which occurred after separation of different compartments containing multiple nuclei connected by a cytoplasmic tube.  Jaw joint degeneration is often preceded by anterior disk displacement (ADD). In a biomechanical analysis we have demonstrated that increased friction does not result in ADD, but to increased shear loading in the cartilage layer on the mandibular condyle. This makes the cartilage layer vulnerable for damage, which ultimately could lead to arthritis/arthrosis in the jaw joint.  Lack of physical activity results in muscle atrophy and bone loss, which can be counteracted by mechanical loading. Similar molecular signalling pathways are involved in the adaptation of muscle and bone mass to mechanical loading. We studied whether anabolic and metabolic factors regulating bone mass are also produced by osteocytes in bone in response to mechanical loading. We found that muscle and bone possibly communicate via endocrine and/or paracrine signaling pathways in response to mechanical loading. 50 Academic Centre for Dentistry Amsterdam
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Mechanosensing by osteocytes is a determining factor in bone adaptation. We found that MT1‐MMP modulates the mechanosensitivity of osteocytes. In addition, we observed that mechanical loading prevents the stimulating effect of IL‐1β on osteocyte‐modulated osteoclastogenesis. Finally, we obtained important new insight in the mechanism of mechanosensing by osteocytes after microscale fluid flow analysis in a human osteocyte canaliculus using a realistic high‐resolution image‐based three‐dimensional model. Our research focuses on the understanding and stimulation of the differentiation of (adipose) stem cells into tissue‐specific cell types for the formation of jaw bone, cartilage, and soft periodontal tissue. Crucial in these processes is a.o. the effects of (growth)factors on stem cell proliferation and differentiation. We have shown that a short (15 minutes only) bone morphogenetic protein‐2 treatment is sufficient to stimulate osteogenic differentiation of human adipose stem cells seeded on calcium phosphate scaffolds. This short pre‐treatment is a very promising tool for use in a clinical one‐step surgical procedure, e.g. the clinical maxillary sinus floor elevation model. Related to the development of enamel fluorosis we found that a single high dose of fluoride in hamster pups induced subameloblastic cysts in the late secretory stage of enamel formation. These cysts posteruptively become enamel defects. Monofluoro phosphate (MFP) was more potent in inducing these defects than NaF. After several weeks of functioning, many white spots eroded into enamel pits. Microcirculation processes are paramount in wound healing and can be seriously damaged by various forms of therapy, especially in patients with a malignancy. The monitoring of microcirculation in these groups of patients gives insight in the aetiology of complications that are often seen after applying tumour therapy or after bone grafts. In two articles, the alternations in microcirculation have been described in patients who underwent radiation therapy. The treatment of patients with a midfacial hypotrophy who underwent radiotherapy in their youth is very challenging. Distraction osteogenesis seems a good option. Several patients have been documented and described showing good functional and aesthetic results. Clinical signs, symptoms and diagnosis  A review of the literature has shown that there is no evidence for a possible causal association between bruxism (teeth clenching and grinding) and occlusal factors. This was further corroborated in a cross‐
sectional study, where the contribution of occlusion to the differentiation between bruxers and non‐
bruxers was found to be negligible.  A large‐scale clinical and population questionnaire study has shown that pain intensity and fear of jaw movements play an important role in the decision to seek care for orofacial pain. The continuous search for help is associated with catastrophizing and the use of painkillers.  Abbreviated versions of the frequently used Oral Health Impairment Profile (OHIP) questionnaire were shown to have good psychometric properties for use in TMD populations. A new questionnaire was developed to enable the assessment of the influence of social support in chronic pain. This Social support and Pain Questionnaire (SPQ) also showed good psychometric properties.  Using Xray subtraction techniques for measuring changes in bone along dental implants were depicted on non‐standardized panoramic radiographs. We concluded that the measuring method is a helpful tool to monitor changes around implants even when non‐standardized radiographs are being used. Whereas changes of marginal bone level are increased five to eight times during the first year after surgery, the presented method shows gradual loss of bone during 15 years after surgery.  The clinical success of a restoration is partly dependent on the acceptation of the patient. Colour and translucency play of the restoration an important role in this acceptation. Unfortunately circa one out of three restorations are clinically not acceptable and the research in this field was focused on the colour determination by the classical shade guides and electronic measurements.  Adverse reactions of metals to the skin are common. Also adverse oral reactions can be related to the use of metals. The use of the palladium salt, sodium tetrachloropalladate, showed that Pd allergy is much more common than previously assumed. Based on the high incidence of Pd and Ni allergy, which are also cross‐reactive, it is advisable to ban Pd out of dental applications.  Voxel gray values from CBCT (Cone‐Beam CT) deviate from actual HUs (Hounsfield Units). This affects usefulness for bone density measurements. However, a strong linear correlation exists, which may permit deriving actual HUs from CBCT scanners.  Two reviews were performed on the use of anticonvulsants and antidepressants in orofacial pain disorders. In both studies a ‘15‐item checklist’ was used to assess the methodological quality of each 51 Annual Research Report 2012
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study. The limited evidence of their effectiveness in pain management and their side effects, make the administration of anticonvulsants and antidepressants in the treatment of pain in patients with orofacial pain questionable. It is important to develop a consensus on the treatment of these disorders using these medications. In a study on pain assessment it was demonstrated that, in contrast to chronic pain patients, a single rating of pain ‘on average’ is not an accurate predictor of the actual ‘average pain’ in patients with pain after surgical removal of the third lower molar. A single pain rating cannot replace a multiple pain rating in these kind of patients. Furthermore, a relative pain reduction of 69% or more was experienced as a “successful” reduction in patients with third molar removal. We analysed the effects of change of direction of masseter (MAS) and medial pterygoid muscles (MPM) and changes of moment arms of MAS, MPM and bite force on static and dynamic loading of the condyles after surgical mandibular advancement. The results do not support the idea that increased postoperative condylar loading is a serious cause for condylar resorption or relapse. We evaluated whether surgical mandibular advancement procedures induced a change in the direction and the moment arms of the masseter (MAS) and medial pterygoid (MPM) muscles. This study demonstrated that bimaxillary surgery in patients with an mpa >39° leads to a significant change of direction of MAS and MPM in the sagittal plane. Treatment planning and rehabilitation  A technique was developed to determine the direction of tooth grinding in vitro, using scratched enamel specimens and scanning electron microscopy. When applied to clinical samples, this technique will be of great value when planning restorative rehabilitation procedures of tooth wear in bruxism (teeth clenching and grinding) patients.  A review of the literature has provided clinicians with suggested clinical approaches for the management of implant prostheses in bruxism patients.  A multi‐center investigation showed that TiZr small‐diameter bone level implants had at least the same outcomes after 12 months as Ti Grade IV bone level implants. The improved mechanical properties of TiZr implants may extend implant therapy to more challenging clinical situations.  Reporting on “Oral function after maxillectomy and reconstruction with an obturator” we concluded that the size of the maxillectomy defect did not significantly influence the functional outcome, but adjuvant radiotherapy resulted in worse mouth opening and oral and swallowing problems. Residual dentition had a positive influence on mastication and subjective outcomes.  Evaluation of implant and superstructure survival by using a reference‐based guided surgery seems to be a reliable treatment option for edentulous patients. The CAD/CAM superstructure, inserted and loaded immediately after guided implant insertion, demonstrated acceptable fit to the underlying implants.  In an in vitro pilot study the aim was to assess the accuracy of the preemptive individually fabricated root analogue implant (RAI) based on three‐dimensional (3D) root surface models obtained from a cone beam computed tomography (CBCT) scan, computer‐aided designing (CAD), and computer‐aided manufacturing (CAM) technology and to measure the discrepancy in congruence with the alveolar socket subsequent to placement of the RAI. We managed to obtain a very high precision when we subtracted scans from the printed RAI from scans of the extracted tooth. We concluded that the preemptive CAD/CAM‐based RAI technique might offer promising features for immediate implant placement.  Clinical and laboratory evaluations of composite materials as restoratives are still important, especially for the long term. Different composites were evaluated in the lab and in vivo after 6 years and the clinical behaviour.. Although in vitro differences were found, clinical outcome for both resin composite materials over 6 years of clinical service was similar. Full composite crown were also clinically evaluated after 3 years. Their survival rate dependent on the cement which was used to lute the crown to the tooth.  Lengthening of the mandible is one of the most frequently performed procedures in maxillofacial surgery. There are two different operation options to achieve this goal, namely, a BSSO and Distraction (DOG) procedure. In a case control study as well as in a RCT, both options have been compared. There is no difference in outcome of therapy between the two groups.  Obstructive sleep apnoea (OSA) is a common affliction. Several therapy options are available. In maxillofacial surgery, the oral appliance is very often used. Moreover, maxillo‐mandibular advancement (MMA) shows good results in patients with severe OSA with a success rate of more than 90%. 52 Academic Centre for Dentistry Amsterdam
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Giant cell granuloma of the jaw bone is a rare and sometimes aggressive disease. The research is focused on the possible value of the use of calcitonin, interferon or denosumab, in aggressive or recurrent giant cell granulomas. Treatment with denosumab shows excellent results in these patients. The incidence of maxillofacial fractures and accompanied complications was investigated in Amsterdam. The study population consisted of 408 males and 171 females with a mean age of 35.9 years. The most common cause of the fractures was traffic related, followed by violence. There were mainly mandibular and zygomatic bone fractures in both males and females (80% of all fractures). The main fracture site of the mandible was the combination of mandibular body with mandibular condyle (66 patients; 26.8%). In fractures of the upper 2/3 of the face, zygomatic bone fractures were most common. The complications consisted of inaccurate reposition and infections. The incidence of venous thromboembolism (VTE) and the need for thromboembolism prophylaxis was investigated in patients undergoing surgery for oral and maxillofacial trauma. Of the 479 patients included in the study, one presented with VTE (0.2%). Surgery time classification proved to have a significant relationship with VTE. For evidence‐based recommendation, a review was performed on clinical trials concerning third molar surgery reporting the use of antibiotic prophylaxis compared with no treatment or placebo with "infection" as outcome. There is limited evidence supporting the efficacy of commonly used antibiotics in preventing complications after lower third molar removal. Academic personnel in 2012 and 2013 Research staff ACTA – ORM Oral Regenerative Medicine (in full time equivalents) position Name Becking, prof.dr. A.G. Beek, prof.dr. H. van Bruggenkate, prof.dr. C.M. ten Gibbs, prof.dr. S. Everts, prof.dr. V. Everts, prof.dr. V. Feilzer, prof.dr. A.J. Klein Nulend, prof.dr. J. Lange, prof.dr. J. de Lobbezoo, prof.dr. F. Full professors Naeije, prof.dr.ir. M. Prahl‐Andersen, prof.dr. B. Roeters, prof.dr. F.J.M. Rozema, prof.dr. F.R. Schulten, prof.dr. E.A.J.M. Stelt, prof.dr. P.F. van der Tuinzing, prof.dr. D.B. Wismeijer, prof.dr. D. Wismeijer, prof.dr. D. Zentner, prof.dr. A. Bronckers, dr. A.L.J.J. Bronckers, dr. A.L.J.J. Habets, dr. L.L.M.H. Kleverlaan, dr. C.J. Senior lecturers Kleverlaan, dr. C.J. Koolstra, dr.ir. J.H. Kuitert, dr. R.B. Sanderink, dr. G.C.H. Visscher, dr. C.M. fte 2012 0,10 0,20 0,10 0,05 0,25 0,05 0,05 0,80 0,10 0,40 0,50 pm 0,20 0,05 0,10 0,20 0,10 0,10 0,10 pm 0,50 0,10 0,20 0,50 0,05 0,60 0,20 0,10 0,50 plan 2013 0,10 ‐‐ 0,05 0,30 0,30 0,05 0,05 0,80 0,20 0,40 0,05 pm 0,20 0,20 0,10 0,20 0,10 0,10 0,10 pm 0,50 0,10 0,20 0,50 0,05 0,60 0,20 0,05 0,50 funding 1 1 1 1 1 2 1 1 1 1 1 guest 3 3 1 1 1 1 3 guest 1 3 1 1 3 1 1 1 1 53 Annual Research Report 2012
position Lecturers and other tenured staff Lecturers and other tenured staff Total tenured staff Non tenured staff 54 Name Algera, dr. T.J. Baart, drs. J.A. Bakker, dr. A.D. Bakker, dr. A.D. Berkhout, dr. W.E.R. Bos, dr. A. Dalen, dr. A., van Diermen, dr. D.E. van Forouzanfar. dr. T. Geraets, dr. W.G.M. Goené, drs. R.J. Hassan, dr. B.A. Jongsma, dr. L.A. Langenbach, dr. G.E.J. Lindeboom, dr. J.A.H. Liu, dr. Y. Liu, dr. Y. Loon, dr. J.J.W.A. van Loon, dr. J.J.W.A. van Loon, dr. J.J.W.A. van Oers, dr.ir. R.F.M. van Prahl, dr. C. Selms, dr. M.K.A. van Tahmaseb, dr. A. Verheij, dr. H.G.C. Vries, dr.ir. T.J. de Vries, dr.ir. T.J. de Wu, dr. G. Al Kurwi, A.S.A. Alfartousi, S. Apperloo, drs. R.C. Ashton, dr. C.E.
Atallah, drs. M.M.
Byraki, drs. A.A.
Chin Jem Sen, drs. J.
Damaskos, dr. S.
Diaz‐Serrano, dr. K.
Disse, drs. M.A.
Dozic, dr. A. Elmi, P. Fabels, L.N.J. Faloni, drs. A.P. Faure, drs. E. Graven, drs. K.M.L. Guo, J. Hermus, R.R. Hoogeveen, msc. R.C.
Hove, R. van
Iskender, S.Y.
Jager, dr.ir. N., de fte 2012 pm 0,10 0,75 0,05 0,10 0,20 0,10 0,20 0,20 0,60 0,10 0,50 0,15 0,40 0,05 0,70 0,15 0,10 0,25 0,25 0,30 0,05 0,20 0,20 0,30 0,60 0,10 0,80 13,70 pm pm 0,10 ‐ pm pm pm pm pm pm pm pm pm pm pm pm 0,70 pm pm pm pm 0,05 plan 2013 pm 0,10 0,80 ‐‐ 0,20 0,10 0,10 0,20 0,20 0,60 0,10 0,60 0,15 0,40 0,05 0,70 0,15 0,10 0,25 0,55 0,75 0,05 0,20 0,30 0,30 0,60 0,10 0,80 14,45 pm pm 0,10 0,30 pm pm pm pm pm pm pm pm pm ‐‐ ‐‐ pm 0,70 pm pm pm pm 0,05 funding guest 1 1 3 1 1 1 1 1 3 1 1 1 1 1 1 3 1 2 3 1 1 1 1 3 1 2 1 guest guest 1 1 guest guest guest guest guest guest guest guest guest guest guest guest 3 guest 1 guest guest 3 Academic Centre for Dentistry Amsterdam
position Non tenured staff PhD students Name Jager, dr. D.H.J. Joosten, M.W. Kaaij, drs. N.C.W. van der Koning, M.J.W. Korstjens, dr. C.M. Kramer, dr. G.J.C. Marpaung, drs. K. Noverraz, drs. R.L.M. Oosterhuis, M. Parvaneh, drs. H. Parys, K. van Prins, dr. H‐J. Prins, dr. H‐J. Ramdat Missier, R.H. Suijkerbuijk, drs. E.
Tabassum, dr. A.
Uijlenbroek, drs. H.J.J. Vermeulen, F.M.J. Vervoorn‐Vis, drs. G. Wetselaar, drs. P. Vries, L. de Wan, Q. Zandieh Doulabi, dr.ing. B. Zembic, dds. A. Zygogiannis, dds. K. Alharbi, dds.N.M. Baas, drs. E.M. Barbery, dds. H. el Bergh, drs. B. van den Blaauboer, drs. M.E. Blaauboer, drs. M.E. Bouwman, drs. W.F. Bronoosh, P. Chalil, S. Chen, dds. C. Delwel, S. Derksen, W.D.C. Dicker, dr. G.J.F.M. Esterik, msc. F.A.S. van Fazaeli, msc. S. Fezari, S. Glim, J.E.
Gooren, msc. E.E.
Gregor, dds. L.
Harkel, msc. B. ten
Holmes, msc. D.B.
Ibrahim, dds. N.
Jaspers, drs. G.W.
Jong, msc. T. de
Juffer, msc. P. Karssemakers, drs. L.H.E. fte 2012 pm pm pm pm 0,20 pm pm pm pm pm pm 0,40 0,30 pm pm 0,15 pm pm pm 0,10 pm 0,75 0,65 0,25 0,20 pm 0,10 0,40 pm 0,40 0,20 pm pm pm 0,75 pm pm pm 0,15 0,75 pm pm 0,15 pm 0,75 0,60 0,75 0,10 0,10 0,75 pm plan 2013 0,15 pm pm pm 0,20 pm pm pm pm pm pm 0,70 ‐‐ pm pm 0,30 pm pm pm 0,10 pm ‐‐ 0,80 0,10 0,60 pm 0,10 ‐‐ 0,10 0,20 ‐‐ pm pm pm 0,60 pm pm pm 0,75 0,75 pm pm 0,75 pm 0,75 ‐‐ 0,65 0,10 0,75 0,10 pm funding 1 guest guest guest 3 guest guest guest guest guest guest 1 2 guest guest 3 guest guest guest 1 guest 2 3 3 3 guest 3 3 1 1 3 guest guest guest 3 guest guest guest 1 1 guest guest 1 guest 2 1 3 3 1 1 guest 55 Annual Research Report 2012
position Name Khashayar, drs. G. Koutris, drs. M. Kommers, msc. S.C. Liu, drs. T. Maningky, drs. M.S. Martin, drs. W.J.J.M. Milheiro, dds. A. Muris, drs. J. Muzalev, drs. K. Nolte, drs. J.W. Oomens, drs. M.A.E.M. Ossendorp, R. Overman, drs. J.R. Parsa, dds. A.
Pathak, msc. J.L.
Renders, drs. G.A.P.
Rhee, msc. A.K. van der Rollman, mw. A. Rozeboom, drs. A.V.J. Ruiter, drs. M.H.T. de Ruiz Zapata, A.M. Ruslin, dds. M. Rutten, S. Salentijn, drs. E. Scholtanus, drs. J.C. Stoker, drs.ir. G.T. Tabeian, msc. H. Tastepe, dds. C.S. Tuijt, drs. M. Velzen, drs. F.J.J. van Vermeer, msc. A.F. Vorselen, msc D. Wang, dds. D. Willems, drs. H.M.E. Zande, msc. M.M. van der PhD students Total non tenured staff total 1st funding total 2nd funding rd
total 3 funding Total research staff fte 2012 0,50 0,30 pm 0,75 pm 0,20 0,50
0,30 pm pm pm pm 0,70 0,75 0,75 0,40 0,75 pm 0,10 ‐‐ pm 0,20 pm pm pm pm 0,70 0,40 0,40 pm 0,75 0,75 pm pm pm 19,00 20,15 plan 2013 0,50 0,20 0,40 0,60 pm ‐ 0,50 0,30 pm pm pm pm ‐ 0,65 0,75 0,40 0,75 pm 0,10 0,10 pm 0,20 pm pm pm pm 0,70 0,40 0,15 pm 0,75 0,75 pm pm pm 13,70 21,20 funding 1 3 1 3 guest 1 1
1 guest guest guest guest guest 3 3 2 1 guest 3 3 guest 3 guest guest guest guest 1 1 1 guest 1 2 3 3 3 1 3,35 2,30 2 9,20 32,70 8,85 32,35 3 Output Dissertations Bonifacio, C.C. (2012, September 07). The ART of GIC proximal restorations in primary teeth. Universiteit van Amsterdam (189 pag.). Prom./coprom.: prof.dr. C. van Loveren, dr. W.E. van Amerongen & dr. C.J. Kleverlaan. Dicker, G.J. (2012, September 06). Adaptation of jaw muscles after surgical mandibular advancement. VU University Amsterdam (150 pag.). Prom./coprom.: prof.dr. D.B. Tuinzing, prof.dr. J.A. Castelijns, dr. T. Forouzanfar & dr.ir. J.H. Koolstra. 56 Academic Centre for Dentistry Amsterdam
Garcia‐Godoy, F. (2012, June 05). Clinical performance of resin composite restorations: the value of accelerated in‐vitro testing. Universiteit van Amsterdam (118 pag.). Prom./coprom.: prof.dr. A.J. Feilzer, prof.dr. R. Frankenberger & dr. N. Krämer. Jongsma, L.A. (2012, March 02). Cementation in adhesive dentistry: the weakest link. Universiteit van Amsterdam (180 pag.). Prom./coprom.: prof.dr. A.J. Feilzer & dr. C.J. Kleverlaan. Kulkarni, R.N. (2012, June 04). Mechanical stimulation of osteocytes and regulation of osteoclastogenesis. VU University Amsterdam (153 pag.). Prom./coprom.: prof.dr. J. Klein Nulend, prof.dr. V. Everts & dr. A.D. Bakker. Vlaar, S.T. (2012, February 15). Validation procedures in computerized dentistry. Universiteit van Amsterdam (156 pag.). Prom./coprom.: prof.dr.ir. J.M. van der Zel. Willems, H.M.E. (2012, December 06). The effect of dietary components on osteocyte mechanosensitivity: implications for bone health. VU University Amsterdam (135 pag.). Prom./coprom.: prof.dr. J. Klein Nulend, dr.ir. E.G.H.M. van den Heuvel & dr. A.D. Bakker. Willems, N.M.B.K. (2012, July 06). Development changes in condylar bone and their mechanical consequences. VU University Amsterdam (167 pag.). Prom./coprom.: prof.dr. A. Zentner, prof.dr. V. Everts & dr. G.E.J. Langenbach. Zaag, J. van der (2012, March 08). Sleep bruxism: contemporary insights in diagnosis, etiology and management. Universiteit van Amsterdam (176 pag.). Prom./coprom.: prof.dr.ir. M. Naeije, prof.dr. F. Lobbezoo & dr. H.L. Hamburger. Scientific publications (refereed) Aboushelib, M.N. (2012). Fatigue and fracture resistance of zirconia crowns prepared with different finish line designs. Journal of Prosthodontics, 21(1), 22‐27. Aboushelib, M.N., Jager, N. de, Kleverlaan, C.J. & Feilzer, A.J. (2012). The influence of pigments on the slow crack growth in dental zirconia. Dental Materials, 28(4), 410‐415. Al‐Nawas, B., Brägger, U., Meijer, H.J.A., Naert, I., Persson, R., Perucchi, A., Quirynen, M., Raghoebar, G.M., Reichert, T.E., Romeo, E., Santing, H.J., Schimmel, M., Storelli, S., Bruggenkate, C. ten, Vandekerckhove, B., Wagner, W., Wismeijer, D. & Müller, F. (2012). A double‐blind Randomized Controlled Trial (RCT) of Titanium‐13Zirconium versus Titanium Grade IV small‐diameter bone level implants in edentulous mandibles: results from a 1‐year observation period. Clinical Implant Dentistry and Related Research, 14(6), 896‐904. Asikainen, P., Ruotsalainen, T.J., Mikkonen, J.J.W., Koistinen, A., Bruggenkate, C. ten & Kullaa, A.M. (2012). The defence architecture of the superficial cells of the oral mucosa. Medical Hypotheses, 78(6), 790‐792. Baas, E.M., Pijpe, J. & Lange, J. de (2012). Long term stability of mandibular advancement procedures: bilateral sagittal split osteotomy versus distraction osteogenesis. International Journal of Oral and Maxillofacial Surgery, 41(2), 137‐141. Baas, E.M., Horsthuis, R.B.G. & Lange, J. de (2012). Subjective alveolar nerve function after bilateral sagittal split osteotomy or distraction osteogenesis of mandible. Journal of Oral and Maxillofacial Surgery, 70(4), 910‐918. Bakker, A.D. & Klein‐Nulend, J. (2012). Bone cell isolation from murine calvaria and long bones. Methods in Molecular Biology, 816, 19‐29. Berendsen, A.D., Vonk, L.A., Zandieh‐Doulabi, B., Everts, V. & Bank, R.A. (2012). Contraction‐induced Mmp13 and‐14 expression by goat articular chondrocytes in collagen type I but not type II gels. Journal of Tissue Engineering and Regenerative Medicine, 6(9), 721‐730. Berge, F. ten, Poel, J. te, Ranjikar, S., Kaidonis, J.A., Lobbezoo, F., Hughes, T.E. & Townsend, G.C. (2012). Determining the direction of tooth grinding: an in vitro study. Journal of Oral Rehabilitation, 39(8), 576‐583. Bergh, B. van den, Karagozoglu, K.H., Heymans, M.W. & Forouzanfar, T. (2012). Aetiology and incidence of maxillofacial trauma in Amsterdam: a retrospective analysis of 579 patients. Journal of Cranio‐Maxillofacial Surgery, 40(6), e165‐e169. Bergh, B. van den, Heymans, M.W., Duvekot, F. & Forouzanfar, T. (2012). Treatment and complications of mandibular fractures: a 10‐year analysis. Journal of Cranio‐Maxillofacial Surgery, 40(4), e108‐e111. Bonifacio, C.C., Werner, A. & Kleverlaan, C.J. (2012). Coating glass‐ionomer cements with a nanofilled resin. Acta Odontologica Scandinavica, 70(6), 471‐477. 57 Annual Research Report 2012
Booij‐Vrieling, H.E., Vries, T.J. de, Schoenmaker, T., Tryfonidou, M.A., Penning, L.C., Hazewinkel, H.A.W. & Everts, V. (2012). Osteoclast progenitors from cats with and without tooth resorption respond differently to 1,25‐dihydroxyvitamin D and interleukin‐6. Research in Veterinary Science, 92(2), 311‐316. Bronckers, A.L.J.J., Guo, J., Lyaruu, D.M., Denbesten, P. & Zandieh‐Doulabi, B. (2012). Immunolocalization and western blotting of the anion exchanger pendrin in ameloblasts. European Journal of Oral Sciences, 120(4), 369‐372. Bronckers, A.L.J.J., Lyaruu, D.M., Bervoets, T.J., Medina, J.F., Denbesten, P., Richter, J. & Everts, V. (2012). Murine ameloblasts are immunonegative for Tcirg1, the v‐H‐ATPase subunit essential for the osteoclast plasma proton pump. Bone, 50(4), 901‐908. Chen, C., Kleverlaan, C.J. & Feilzer, A.J. (2012). Effect of an experimental zirconia‐silica coating technique on micro tensile bond strength of zirconia in different priming conditions. Dental Materials, 28(8), E127‐E134. Creton, M., Geraets, W., Verhoeven, J.W., Stelt, P.F. van der, Verhey, H. & Cune, M. (2012). Radiographic features of mandibular trabecular bone structure in hypodontia. Clinical Implant Dentistry and Related Research, 14(2), 241‐249. Dicker, G.J., Koolstra, J.H., Castelijns, J.A., Schijndel, R.A. van & Tuinzing, D.B. (2012). Positional changes of the masseter and medial pterygoid muscles after surgical mandibular advancement procedures: an MRI study. International Journal of Oral and Maxillofacial Surgery, 41(8), 922‐929. Dicker, G.J., Tuijt, M., Koolstra, J.H., Schijndel, R.A. van, Castelijns, J.A. & Tuinzing, D.B. (2012). Static and dynamic loading of mandibular condyles and their positional changes after bilateral sagittal split advancement osteotomies. International Journal of Oral and Maxillofacial Surgery, 41(9), 1131‐1136. Eerden, B.C.J., Weissgerber, P., Fratzl‐Zelman, N., Olausson, J., Hoenderop, J.G.J., Schreuders‐Koedam, M., Eijken, M., Roschger, P., Vries, T.J. de, Chiba, H., Klaushofer, K., Flockerzi, V., Bindels, R.J.M., Freichel, M. & Leeuwen, J.P.T.M. (2012). The transient receptor potential channel TRPV6 is dynamically expressed in bone cells but is not crucial for bone mineralization in mice. Journal of Cellular Physiology, 227(5), 1951‐1959. Everts, V., Niehof, A., Tigchelaar‐Gutter, W. & Beertsen, W. (2012). Transmission electron microscopy of bone. Methods in Molecular Biology, 816, 351‐363. Farré‐Guasch, E., Prins, H‐J., Overman, J.R., Bruggenkate, C.M. ten, Schulten, E.A.J.M., Helder, M.N. & Klein‐
Nulend, J. (2012). Human maxillary sinus floor elevation as a model for bone regeneration enabling the application of one‐step surgical procedures. Tissue Engineering, Pt. B, Reviews, 19(1), 69‐82. Gabriel, M., Nazmi, K., Dahm, M., Zentner, A., Vahl, C.F. & Strand, D. (2012). Covalent RGD modification of the inner pore surface of polycaprolactone scaffolds. Journal of Biomaterials Science‐Polymer Edition, 23(7), 941‐953. Galassi, F., Kaman, W.E., Anssari Moin, D., Horst, J. van der, Wismeijer, D., Crielaard, W., Laine, M.L., Veerman, E.C.I., Bikker, F.J. & Loos, B.G. (2012). Comparing culture, real‐time PCR and fluorescence resonance energy transfer technology for detection of Porphyromonas gingivalis in patients with or without peri‐implant infections. Journal of Periodontal Research, 47(5), 616‐625. Garcia‐Godoy, F., Frankenberger, R., Lohbauer, U., Feilzer, A.J. & Kraemer, N. (2012). Fatigue behavior of dental resin composites: Flexural fatigue in vitro versus 6 years in vivo. Journal of Biomedical Materials Research. Part B Applied Biomaterials, 100B(4), 903‐910. Geraets, W.G.M., Verheij, H.G.C., Wismeijer, D. & Stelt, P.F. van der (2012). Detecting bone loss along dental implants by subtraction of panoramic radiographs. Clinical Oral Implants Research, 23(7), 861‐865. Geraets, W.G.M., Lindh, C. & Verheij, H. (2012). Sparseness of the trabecular pattern on dental radiographs: visual assessment compared with semi‐automated measurements. British Journal of Radiology, 85(1016), E455‐E460. Grosse, J., Wehland, M., Pietsch, J., Ma, X., Ulbrich, C., Schulz, H., Saar, K., Hübner, N., Hauslage, J., Hemmersbach, R., Braun, M., Loon, J. van, Vagt, N., Invanger, M., Eiles, C., Egli, M., Richter, P., Baltz, T., Einspanier, R., Sharbati, S. & Grimm, D. (2012). Short‐term weightlessness produced by parabolic flight maneuvers altered gene expression patterns in human endothelial cells. The FASEB Journal, 26(2), 639‐655. Guo, J. & Wu, G. (2012). The signaling and functions of heterodimeric bone morphogenetic proteins. Cytokine & Growth Factor Reviews, 23(1), 61‐67. Hassan, B.A., Payam, J., Juyanda, B., Stelt, P. van der & Wesselink, P.R. (2012). Influence of scan setting selections on root canal visibility with cone beam CT. Dentomaxillofacial Radiology, 41(8), 645‐648. Herranz, R., Larkin, O.J., Dijkstra, C.E., Hill, R.J.A., Anthony, P., Davey, M.R., Michael, R., Eaves, L., Loon, J.J.W.A. van, Medina, F.J. & Marco, R. (2012). Microgravity simulation by diamagnetic levitation: effects of a strong gradient magnetic field on the transcriptional profile of Drosophila melanogaster. BMC Genomics, 13, 1‐13. Huesa, C. & Bakker, A.D. (2012). Mechanical stimulation of bone cells using fluid flow. Methods in Molecular Biology, 816, 573‐592. 58 Academic Centre for Dentistry Amsterdam
Hunziker, E.B., Enggist, L., Küffer, A., Buser, D. & Liu, Y. (2012). Osseointegration: the slow delivery of BMP‐2 enhances osteoinductivity. Bone, 51(1), 98‐106. Husebo, B.S., Kunz, M., Achterberg, W.P., Lobbezoo, F., Kappesser, J., Tudose, C., Strand, L.I. & Lautenbacher, S. (2012). Pain assessment and treatment challenges in patients with dementia. Scherzmessung und –
behandlung bei Patienten mit Demenz. Zeitschrift fur Neuropsychologie, 23(4), 237‐246. Jansen, I.D.C., Vermeer, J.A.F., Bloemen, V., Stap, J. & Everts, V. (2012). Osteoclast fusion and fission. Calcified Tissue International, 90(6), 515‐522. Jongsma, L.A., Kleverlaan, C.J. & Feilzer, A.J. (2012). Clinical success and survival of indirect resin composite crowns: results of a 3‐year prospective study. Dental Materials, 28(9), 952‐960. Jongsma, L.A., Kleverlaan, C.J., Pallav, P. & Feilzer, A.J. (2012). Influence of polymerization mode and C‐factor on cohesive strength of dual‐cured resin cements. Dental Materials, 28(7), 722‐728. Jongsma, L.A., Jager, N. de, Kleverlaan, C.J., Pallav, P. & Feilzer, A.J. (2012). Shear bond strength of three dual‐cured resin cements to dentin analyzed by finite element analysis. Dental Materials, 28(10), 1080‐
1088. Juffer, P., Jaspers, R.T., Lips, P., Bakker, A.D. & Klein‐Nulend, J. (2012). Expression of muscle anabolic and metabolic factors in mechanically loaded MLO‐Y4 osteocytes. American Journal of Physiology. Endocrinology and Metabolism, 302(4), E389‐E395. Kamioka, H., Kameo, Y., Imai, Y., Bakker, A.D., Bacabac, R.G., Yamada, N., Takaoka, A., Yamashiro, T., Adachi, T. & Klein‐Nulend, J. (2012). Microscale fluid flow analysis in a human osteocyte canaliculus using a realistic high‐resolution image‐based three‐dimensional model. Integrative Biology, 4(10), 1198‐1206. Khashayar, G., Dozic, A., Kleverlaan, C. & Feilzer, A.J. (2012). Clinical success of shade guides arranged according to lightness measured digitally. The International Journal of Prosthodontics, 25(4), 410‐412. Khashayar, G., Dozic, A., Kleverlaan, C.J. & Feilzer, A.J. (2012). Data comparison between two dental spectrophotometers. Operative Dentistry, 37(1), 12‐20. Klein‐Nulend, J., Bacabac, R.G. & Bakker, A.D. (2012). Mechanical loading and how it affects bone cells: the role of the osteocyte cytoskeleton in maintaining our skeleton. European Cells & Materials, 24, 278‐291. Komiyama, O., Lobbezoo, F., Laat, A. de, Iida, T., Kitagawa, T., Murakami, H., Kato, T. & Kawara, M. (2012). Clinical management of implant prostheses in patients with bruxism. International Journal of Biomaterials, 2012(369063), 1‐6. Koolstra, J.H. (2012). Biomechanical analysis of the influence of friction in jaw joint disorders. Osteoarthritis and Cartilage, 20(1), 43‐48. Korfage, J.A.M., Wang, J., Lie, S.H.J.T.J. & Langenbach, G.E.J. (2012). Influence of botulinum toxin on rabbit jaw muscle activity and anatomy. Muscle & Nerve, 45(5), 684‐691. Kreeft, A.M., Krap, M., Wismeijer, D., Speksnijder, C.M., Smeele, L.E., Bosch, S.D., Muijen, M.S.A. & Balm, A.J.M. (2012). Oral function after maxillectomy and reconstruction with an obturator. International Journal of Oral and Maxillofacial Surgery, 41(11), 1387‐1392. Kulkarni, R.N., Bakker, A.D., Everts, V. & Klein‐Nulend, J. (2012). Mechanical loading prevents the stimulating effect of IL‐1 beta on osteocyte‐modulated osteoclastogenesis. Biochemical and Biophysical Research Communications, 420(1), 11‐16. Kulkarni, R.N., Bakker, A.D., Gruber, E.V., Chae, T.D., Veldkamp, J.B.B., Klein‐Nulend, J. & Everts, V. (2012). MT1‐MMP modulates the mechanosensitivity of osteocytes. Biochemical and Biophysical Research Communications, 417(2), 824‐829. Lobbezoo, F., Ahlberg, J., Manfredini, D. & Winocur, E. (2012). Are bruxism and the bite causally related? Journal of Oral Rehabilitation, 39(7), 489‐501. Loon, J.J.W.A. van, Baeyens, J.P., Berte, J., Blanc, S., Braak, L. ter, Bok, K., Bos, J., Boyle, R., Bravenboer, N., Eekhoff, E.M.W., Chouker, A., Clement, G., Cras, P., Cross, E., Custaud, M‐A, De Angelis, M., Delavaux, T., Delfos, R., Poelma, C., Denise, P., Felsenberg, D., Delavy, D., Fong, K., Fuller, C., Grillner, S., Groen, E., Harlaar, J., Heer, M., Heglund, N., Hinghofer‐Szalkay, H., Goswami, N., Hughes‐Fulford, M., Iwase, S., Karemaker, J.M., Langdahl, B., Linarsson, D., Lüthen, C., Monici, M., Mulder, E., Narici, M., Norsk, P., Paloski, W., Prisk, G.K., Rutten, M., Singer, P., Stegeman, D.F., Stephan, A., Stienen, G.J.M., Suedfeld, P., Tesch, P., Ullrich, O., Berg, R. van den, Heyning, P. Van de, Delahaye, A., Veyt, J., Vico, L., Woodward, E., Young, L.R. & Wuyts, F. (2012). A large human centrifuge for exploration and exploitation research. Annales Kinesiologiae, 3(1), 107‐121. Lugt, C.M.C., Rollman, A., Naeije, M., Lobbezoo, F. & Visscher, C.M. (2012). Social support in chronic pain: development and preliminary psychometric assessment of a new instrument. Journal of Oral Rehabilitation, 39(4), 270‐276. 59 Annual Research Report 2012
Lyaruu, D.M., Vermeulen, L., Stienen, N., Bervoets, T.J.M., Denbesten, P.K. & Bronckers, A.L.J.J. (2012). Enamel pits in hamster molars, formed by a single high fluoride dose, are associated with a perturbation of transitional stage ameloblasts. Caries Research, 46(6), 575‐580. Manfredini, D., Visscher, C.M., Guarda‐Nardini, L. & Lobbezoo, F. (2012). Occlusal factors are not related to self‐reported bruxism. Journal of Orofacial Pain, 26(3), 163‐167. Manfredini, D., Winocur, E., Guarda‐Nardini, L. & Lobbezoo, F. (2012). Self‐reported bruxism and temporomandibular disorders: findings from two specialised centres. Journal of Oral Rehabilitation, 39(5), 319‐325. Manzano, A.I., Herranz, R., Loon, J.J.W.A. van & Medina, F.J. (2012). A hypergravity environment induced by centrifugation alters plant cell proliferation and growth in an opposite way to microgravity. Microgravity Science and Technology, 24(6), 373‐381. Manzano, A.I., Loon, J.J.W.A. van, Christianen, P.C.M., Gonzalez‐Rubio, J.M., Juana, M., Medina, F.J. & Herranz, R. (2012). Gravitational and magnetic field variations synergize to cause subtle variations in the global transcriptional state of Arabidopsis in vitro callus cultures. BMC Genomics, 13(105), 1‐13. Martin, W..J.J.M., Heymans, M.W., Skorpil, N.E. & Forouzanfar, T. (2012). Can a single pain rating replace a multiple pain rating in third molar surgery studies? Analysis of 220 patients. International Journal of Oral and Maxillofacial Surgery, 41(8), 1010‐1013. Martin, W..J.J.M., Perez, R.S.G.M., Tuinzing, D.B. & Forouzanfar, T. (2012). Efficacy of antidepressants on orofacial pain: a systematic review. International Journal of Oral and Maxillofacial Surgery, 41(12), 1532‐
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Westing, K. van, Algera, T.J. & Kleverlaan, C.J. (2012). Rebond strength of bonded lingual wire retainers. European Journal of Orthodontics, 34(3), 345‐349. Willems, H.M.E., Heuvel, E.G.H.M. van den, Carmeliet, G., Schaafsma, A., Klein‐Nulend, J. & Bakker, A.D. (2012). VDR dependent and independent effects of 1,25‐dihydroxyvitamin D‐3 on nitric oxide production by osteoblasts. Steroids, 77(1), 126‐131. Wu, L., Prins, H‐J., Helder, M.N., Blitterswijk, C.A. van & Karperien, M. (2012). Trophic effects of mesenchymal stem cells in chondrocyte co‐cultures are independent of culture conditions and cell sources. Tissue Engineering. Part A, 18(15‐16), 1542‐1551. Yoshida, E., Lobbezoo, F., Fueki, K. & Naeije, M. (2012). Effects of delayed‐onset muscle soreness on masticatory function. European Journal of Oral Sciences, 120(6), 526‐530. Zheng, Y., Wang, L., Zhang, X., Zhang, X., Gu, Z. & Wu, G. (2012). BMP2/7 heterodimer can modulate all cellular events of the in vitro rankl‐mediated osteoclastogenesis, respectively, in different dose patterns. Tissue Engineering. Part A, 18(5‐6), 621‐630. Scientific publications ( non refereed)
Husebo, B.S., Achterberg, W.P., Lobbezoo, F., Kunz, M., Lautenbacher, S., Kappesser, J., Tudose, C. & Strand, L.I. (2012). Pain in patients with dementia: An overview of pain assessment and treatment challenges. Norsk Epidemiologi/Norwegian Journal of Epidemiology, 22, 243‐251. Jansen, I.D.C., Vermeer, J.A.F., Bloemen, V., Stap, J. & Everts, V. (2012). Osteoclast Fusion and Fission: authors' reply. Calcified Tissue International, 91(2), 159. Lobbezoo, F. (2012). À propos du bruxisme. In S. Armand (Ed.), Association Dentaire Française: Quintessence du Congrès 2012 (pp. 293‐295). Paris. Mans, R.S., Reijers, H.A., Genuchten, M. van & Wismeijer, D. (2012). Mining processes in dentistry. In Proceedings of the 2nd ACM SIGHIT (pp. 379‐388). ACM New York. Professional publications Allard, R.H.B., Bruers, J.J.M. & Baart, J.A. (2012). Het indiceren van analgenetica in de mondzorg. Nederlands Tijdschrift voor Tandheelkunde, 119(7‐8), 379‐384. Avoort, G. van der, Endstra, L., Horst, J. van der & Anssari Moin, D. (2012). Nazorg bij implantaten: diagnostiek en uitvoering. Quality Practice. Nascholingstijdschrift voor mondhygiënisten, 4(4), 13‐28. Becking, A.G. (2012). MKA‐chirurgie, gezichtsbepalend. Benoeming tot bijzonder hoogleraar Mondziekten, Kaak‐ en Aangezichtschirurgie (2012, June 15). Amsterdam: Universiteit van Amsterdam. Beek, H. van (2012). Driedimensionale technologie. Nederlands Tijdschrift voor Tandheelkunde, 119(2), 51. Beek, H. van (2012). Vaste draadspalken tegen (her)optreden van gedrongen stand hebben meer nadelen dan voordelen. Ja. Nederlands Tijdschrift voor Tandheelkunde, 119(5), 230. Beek, H. van (2012). Boekbespreking [Bespreking van het boek Construction and application of substitutes for oral mucosa in cleft palate repair]. Nederlands Tijdschrift voor Tandheelkunde, 118. Beek, H. van (2012). Boekbespreking. Gevolgen van orthodontische verplaatsingen [Bespreking van het boek Changes in periodontal ligament and dental pulp after experimental orthodontic tooth movement]. Nederlands Tijdschrift voor Tandheelkunde, 119(3), 153. Berkhout, W.E.R. (2012). Standaard. Nederlands Tandartsenblad, 9, 33. Bots, C.P., Dalen, A. van & Cools, H.J.M. (2012). Lang leve de duurzame medische mondzorg. Nederlands Tijdschrift voor Tandheelkunde, 119(1), 13‐16. Bruyn, L.D. de, Diermen, D.E. van & Wismeijer, D. (2012). Beschouwingen over het gebruik van corticosteroïden in de dentoalveolaire chirurgie. Nederlands Tijdschrift voor Tandheelkunde, 119(9), 425‐
430. Dalen, A. van & Calcar, N.P. van (2012). Cuspidaat substitutie, orthodontie als alternatief voor implantologie. De Tandartspraktijk, 33(10), 15‐20. Dalen, A. van (2012). Geen implantologie door bijzondere anatomie. De Tandartspraktijk, 33(7), 11‐13. Dalen, A. van (2012). Indirecte cantilever adhesiefbrug. De Tandartspraktijk, 33(7), 4‐10. Diermen, D.E. van, Brand, H.S. & Makkes, P.C. (2012). De medische anamnese in de tandheelkundige praktijk. In H.S. Brand, D.E. van Diermen & P.C. Makkes (Eds.), Algemene ziekteleer voor tandartsen (3e geheel herziene druk) (pp. 13‐20). Houten/Diegem: Bohn Stafleu van Loghum. 62 Academic Centre for Dentistry Amsterdam
Eijkman, M.A.J., Baat, C. de, Beek, H. van, Brand, H.S., Frankenmolen, F.W.A., Liem, S.A., Loveren, C. van, Luijk, A.M. van, Palenstein Helderman, W.H. van, Poorterman, J.H.G., Visscher, J.G.A.M. de & Zeghbroek, L. van (2012). De mondzorg van morgen. Nederlands Tijdschrift voor Tandheelkunde, 119(7‐8), 347. Everts, V. (2012). Regeneratie van weefsels: waar ligt de grens? Quality practice. Nascholingstijdschrift voor tandartsen, 7(5), 30‐33. Frank, M.H., Baas, E.M. & Lange, J. de (2012). Peri‐implantitis in de algemene kaakchirurgische praktijk. Een pilotonderzoek. Nederlands Tijdschrift voor Tandheelkunde, 119(3), 123‐128. Geraets, W.G.M. & Wismeijer, D. (2012). Röntgenopnamen voor het vaststellen van botverlies rond implantaten. Een exploratie van de mogelijkheden. Nederlands Tijdschrift voor Tandheelkunde, 119(2), 59‐
61. Hoekema, A., Apperloo, R.C. & Lange, J. de (2012). Een zeldzame complicatie bij verwijdering van een geïmpacteerde derde molaar in de bovenkaak. Nederlands Tijdschrift voor Tandheelkunde, 119(7‐8), 363‐
366. Horst, J. van der (2012). Patiënten met orale implantaten en risicofactoren. Quality practice. Nascholingstijdschrift voor mondhygiënisten, 4(4), 8‐12. Jongh, A. de & Roeters, F.J.M. (2012). Een mooi gebit, een waardevol bezit. Quality Practice. Nascholingstijdschrift voor tandartsen, 8(2), 8‐13. Jongsma, L.A. (2012). Nieuwe techniek: tweestapscementatieprocedure. Cementlaag vaak zwakste schakel in de adhesieve tandheelkunde. De Tandartspraktijk, 33(4), 35‐39. Karssemakers, L.H.E., Nolte, J.W., Saridin, C.P., Raijmakers, P.G.H.M. & Becking, A.G. (2012). Unilaterale condylaire hyperactiviteit. Nederlands Tijdschrift voor Tandheelkunde, 119(10), 500‐504. Kleverlaan, C. (2012). Metaalvrij heeft de toekomst. Nederlands Tandartsenblad, 67(4), 33‐35. Lobbezoo, F., Wetselaar, P., Zaag, J. van der & Naeije, M. (2012). Attritiepreventie: (te) doen? Quality Practice. Nascholingstijdschrift voor mondhygiënisten, 4(3), 19‐23. Lobbezoo, F. & Kersten, H.W. (2012). Implantaten bij patiënten met bruxisme. Quality Practice. Nascholingstijdschrift voor mondhygiënisten, 4(4), 29‐36. Prahl, C. (2012). Boekbespreking. Bilaterale schisis [Bespreking van het boek Treatment outcome in patients with bilateral cleft lip and palate. An intercentre study on dentofacial morphology until 12 years of age]. Nederlands Tijdschrift voor Tandheelkunde, 119(5), 264. Prahl‐Andersen, B. (2012). Boekbespreking. Verbetering van spierregeneratie [Bespreking van het boek Improving the regeneration of injured muscle]. Nederlands Tijdschrift voor Tandheelkunde, 119(1), 44. Roeters, F.J.M. & Kleverlaan, C.J. (2012). Niet te snel kiezen voor bulk‐fill composiet. Nederlands Tandartsenblad, 67(21), 24‐25. Schoonheim‐Klein, M.E., Selms, M.K.A. van, Volgenant, C.M.C., Wiegman, H.P. & Vervoorn, J.M. (2012). Het beoordelen van de klinische competenties van studenten tandheelkunde. Nederlands Tijdschrift voor Tandheelkunde, 119(6), 328‐336. Schulten, E.A.J.M. (2012). Reconstructie van kaakdefecten na chirurgische tumorbehandeling: Chirurgische en prothetische mogelijkheden. Quality Practice. Nascholingstijdschrift voor tandartsen, 8(3), 42‐49. Stelt, P. van der (2012). Cone beam‐computertomografie is niet meer weg te denken uit de algemene praktijk. Nee. Nederlands Tijdschrift voor Tandheelkunde, 119(4), 167. Visscher, C.M., Lobbezoo, F., Tuijt, M., Koolstra, J.H. & Naeije, M. (2012). Habituele luxaties van de onderkaak. Casus van een jonge vrouw. Quality Practice. Nascholingstijdschrift voor tandartsen, 7(4), 17‐
20. Visscher, C.M., Lobbezoo, F. & Naeije, M. (2012). Pijn in de kaken tijdens kauwen. In P. Calders, J.J.X.R. Geraets, J. Nijs, C. Veenhof, E.E.H. van Wegen & C.P. van Wilgen (Eds.), Jaarboek Fysiotherapie Kinesitherapie 2012 (pp. 70‐87). Houten: Bohn Stafleu van Loghum. Waas, M.A.J. van (2012). Boekbespreking. Slaapbruxisme [Bespreking van het boek Sleep bruxism. Contemporary insights in diagnosis, etiology and management]. Nederlands Tijdschrift voor Tandheelkunde, 119(9). Waas, M.A.J. van (2012). Boekbespreking. Temporomandibulaire disfunctie [Bespreking van het boek Psychological screening of temporomandibular disorder patients]. Nederlands Tijdschrift voor Tandheelkunde, 119(4), 216. Wetselaar, P., Zaag, J. van der & Lobbezoo, F. (2012). Diagnostiek van gebitsslijtage. Quality Practice. Nascholingstijdschrift voor mondhygiënisten, 4(3), 14‐18. Wetselaar, P., Kuijs, R.H., Pelt, A.W.J. van, Zaag, J. van der, Roeters, F.J.M. & Lobbezoo, F. (2012). Overwegingen bij de behandeling van gebitsslijtage. Nederlands Tijdschrift voor Tandheelkunde, 119(11), 549‐553. 63 Annual Research Report 2012
Wismeijer, D. (2012). Boekbespreking [Bespreking van het boek Dental Implant Restoration. Principles and Procedures]. Nederlands Tandartsenblad, 9, 33. Zaag, J. van der, Osiewicz, M. & Lobbezoo, F. (2012). Herstel van gebitsslijtage ‐ een casus. Quality Practice. Nascholingstijdschrift voor mondhygiënisten, 4(3), 30‐36. Publications aimed for the general public Bakker, A.D. & Klein‐Nulend, J. (2012). Bewegende botten breken niet. Cahiers Bio‐Wetenschappen en Maatschappij, 2, 34‐36. Eijkman, M.A.J. (28‐01‐2012). Implantaat sneuvelt niet vaak. NRC Handelsblad Eijkman, M.A.J. (08‐12‐2012). Kaakproblemen door een slecht passend mondstuk. NRC Handelsblad Eijkman, M.A.J. (06‐03‐2012). Tandenknarsen verwant aan been bewegen. NRC Handelsblad Feilzer, A.J. (2012). Kronen uit de 3D‐printer. Zin, 33(7), 11‐13. Patents Liu, Y. & Wismeijer, D. (2012) Particles, useful for treating bone defect and/or peri‐implantitis, preferably peri‐
implantitis induced bone defect, and as bone filler or bone replacement, comprise core comprising amorphous calcium phosphate and first layer around core, WO2012093939‐A1. Book editorship Brand, H.S., Diermen, D.E. van & Makkes, P.C. (Eds.). (2012). Algemene ziekteleer voor tandartsen. ‐ 3e dr. Houten: Bohn Stafleu van Loghum. Wismeijer, D., Chen, S. & Buser, D. (Eds.). (2012). Extended edentulous spaces in the esthetic zone (ITI treatment guide, 6). Berlin: Quintessence. Wismeijer, D. (Ed.). (2011). The ITI treatment guide Vol‐5, first edition. Sinus floor elevation procedures. Translations in Spanish, German, French, Italian, Portuguese, Japanese and Turkish (ITI treatment guide, 5). Berlin: Quintessenz Verlags‐GmbH. Indicators of Esteem Grants: current projects with external funding Bank, R.A. & Everts V: TNO beurs Kenniscentrum, NITE project; AIO (1 fte) 2007‐2012. Boer, S. de, Koolhaas, J.M. & Loon, J.J.W.A. van: NWO‐ALW a 4 years PhD Grant: Title: “Coping with altered gravity: orchestrating role of brain serotonin”. Bronckers, A.L.J.J.: NIH grant on dental fluorosis a 3 year extension to end of 2014 (87 k US $ per year) Bruggenkate, C.M. ten. Research on maxillofacial implantology. (2008‐2012) Straumann; € 50.000,‐ Christiansen, C., Svensson, P. & Lobbezoo, F. Development of a user‐friendly bruxism treatment device. Fornyelsesfonden – Grøn Innovation, €117.000,‐. Start project: 2012. End project: 2015. Everts, V. KNAW grant for collaboration with China on a 2‐year project. Postdoc Q. Wong, €45,170.‐. December 2010‐November 2012. Everts, V. NIRM grant on multinucleated giant cells. PhD student, €280.000,‐ September 2011‐2015. Everts, V., Lenthe, H. van, Koolstra, J.H. & Lobbezoo, F. Biomechanical changes in articulation of the jaw joint due to aging. EU‐MOVE‐AGE PhD Program. Gorter, R.C. & Wismeijer, D. “Digital dentistry in practice; On dentists' interaction with technological transformations” to be led by dr. Gorter with an ITI research grant to the amount of CHF 123’821. Granted. Gucht, J. van der & Loon, J.J.W.A. van: NWO‐ALW: 4 years PhD Grant: Title: “Self‐organization and dynamics of actin networks under microgravity conditions”. Iannuzzi, D., MacKintosh, F. & Loon, J.J.W.A. van: ESA‐NPI grant: A 3 years Co‐sponsored PdD position: Title: “Ferrule‐top AFM for space applications.” 2011‐2013. Klein Nulend, J., Bruggenkate, C.M. ten, Helder, M. & E.A.J.M. Schulten. Bone augmentation with autologous stem cells in sinus floor elevation. ZON‐MW; € 650.000. (2009‐2012). 64 Academic Centre for Dentistry Amsterdam
Klein‐Nulend, J. & Bakker, A.D. Servier project: Effect of strontium ranelate on the osteocyte response to mechanical loading and osteocyte communication towards osteoblasts (PI: Klein‐Nulend J, Co‐PI: Bakker AD) (€ 207,610, 1 fte postdoc, 1 fte technician for 1 yr), 2012. Klein‐Nulend, J. & Hespel, P. (Leuven): European Union: MOVE‐AGE Erasmus Mundus Joint Doctorate Program “Prevention of mobility loss with ageing”: Understanding muscle and bone anabolic resistance in ageing: is ER stress involved? (MOVE‐AGE project 2011‐2014 € 180.000). Klein‐Nulend, J. & Luyten, F.P. (Leuven): European Union: MOVE‐AGE Erasmus Mundus Joint Doctorate Program “Prevention of mobility loss with ageing”: The etiology of generalized osteoporosis in rheumatoid arthritis (MOVE‐AGE project 2011‐2014 € 180.000). Klein‐Nulend, J. Royal Friesland‐Campina project: Combined effect of physical activity and nutrition on bone metabolism, “Nutribone” (€ 422.880, 1 fte AIO for 4 yrs), 2007‐2012. Klein‐Nulend, J., Everts, V., Feilzer, A.J. & Kleverlaan, C.J. Dentistry of the Future: Oral Regenerative Medicine (Additional Financing Research Priority Area 2012 University of Amsterdam 2012‐2016 € 1.650.000). Lange, J. de & Apperloo, R.C. Dental implants as anchorage for prostheses; number, configuration and suprastructure. Straumann. Duration of the project 2010‐2015. Lange, J. de & Baas, EM. BSSO versus distraction of the mandible. Martin. Duration of the project 2007‐2012. Lange, J. de & Jaspers, G.W. Medication in implant dentistry. Straumann. Duration of the project 2010‐2015. Lange, J. de & Rozeboom, A.V.J. Fractures of the condylar head. Synthes 2011‐2014. Lange, J. de. Oral appliance versus positional therapy. Nutsohra fonds. 2012‐2014. Lautenbacher, S., Achterberg, W., Husebo, B. & Lobbezoo, F. et al. Pain assessment in patients with impaired cognition, especially dementia. EU‐COST Action TD1005, €400.000,‐. Start project: 2011. End project: 2015. Liu, Y., Liu, T. & Wismeijer, D. ITI grant. Granted 36.000. February 2012. Lobbezoo, F. Validity of Grindcare® diagnosis of sleep bruxism. Medotech A/S Project Grant, € 13.532,80. Start project: 2012. End project: 2013. Loon, J.J.W.A. van: NWO PhD‐project, 2011‐2015, Muzalev, K., Yoshida, E., Wismeijer, D. & Lobbezoo F. Associations between sleep bruxism and peri‐implant complications: a follow‐up study. NVGPT Onderzoekssubsidie, €5.000,‐. Start project: 2012. End project: 2015. Renders, G.A.P. (2007) Consequences of mechanical interaction between cartilage and bone for development of osteoarthrosis. NWO Toptalent (EUR 180.000). 2007‐2012. Tabassum, A. Tahmaseb A., Liu, Y. & Wismeijer, D. CAMLOG Foundation: A modified drilling protocol for implant site preparation and subsequent collection of bone autograft: A randomized controlled trial. Granted 73.210. September 2012. Tabassum, A., Wu, G., Liu, Y. & Wismeijer, D. ITI grant: Granted 36.000. February 2012. Visscher, C.M. Determinanten voor mondgezondheid gerelateerde kwaliteit van leven (samenwerking met TNO). Nederlandse Vereniging voor Gnathologie en Prothetische Tandheelkunde, €5.000,‐. Start project: 2011. End project: 2012. Visscher, C.M. Invloed van comorbiditeit op diagnostische validiteit van klinische tests voor musculoskelettale pijn. Wetenschappelijk College Fysiotherapie, €40.000,‐. Start project: 2011. End project: 2012. Wismeijer, D. & Eekeren, P. van. The comparisson of osseointegration of Apliquiq implants with immediate vs delayed loading. A split mouth design. Thommen medical. Granted 80.000. Wismeijer, D. & Liu, Y. Peri‐implantitis project 46 Straumann implants. Granted inkind. Wismeijer, D. A pilot study looking at the treatment of edentulous patients with mini implants. Granted 22.000. Wismeijer, D. Comparing the immediate loading (within 48 hours) of two interconnected implants with an overdenture to the immediate loading of 4 Mini Dental implants and an overdenture in a Randomized Controlled Clinical trial. Granted 213.727. Wu, G. Liu, Y. & Wismeijer, D. ITI grant. Granted 143.900. August 2012. Membership of international editorial boards Aarab, G.: Bronckers, A.L.J.J.: Bruggenkate, C.M. ten: Dozic, A.: Everts, V.: Everts, V.: Journal of Dental Sleep Medicine. Odontology. Clinical Oral Implants Research. Journal of Dentistry. International Journal of Dentistry. International Journal of Oral Research. 65 Annual Research Report 2012
Everts, V.: Everts, V.: Feilzer, A.J.: Feilzer, A.J.: Forouzanfar, T.: Goené, R.J.: Goené, R.J.: Klein‐Nulend, J.: Klein‐Nulend, J.: Klein‐Nulend, J.: Klein‐Nulend, J.: Klein‐Nulend, J.: Klein‐Nulend, J.: Koolstra, J.H.: Lobbezoo, F.: Lobbezoo, F.: Naeije, M.: Sanderink, G.C.H.: Stelt, P.F. van der: Stelt, P.F. van der: Stelt, P.F. van der: Stelt, P.F. van der: Visscher, C.M.: The Open Bone Journal. The Open Enzyme Inhibition Journal. American Journal of Dentistry. Odontology. Medicina Oral European Journal of Oral Implantology. Journal of Implant and Reconstructive Dentistry. Clinical Reviews in Bone and Mineral Metabolism. Experimental and Clinical Endocrinology & Diabetes. Journal of Musculoskeletal Research. The Open Biology Journal. The Open Nitric Oxide Journal. The Open Tissue Engineering and Regenerative Medicine Journal. Journal of Dental Biomechanics. Journal of Craniomandibular Function. Journal of Oral Rehabilitation. Journal of Oral Rehabilitation. Dentomaxillofacial Radiology. Clinical Oral Implants Research. Dentomaxillofacial Radiology. Journal of Dentistry Shiraz University of Medical Sciences. Odontology. Journal of Craniomandibular Function. Scientific awards/honours Bergh, B. van den (2012, November 02). Marten Hut‐Prize for the best presentation. Najaarsvergadering NVMKA: Noordwijk, the Netherlands. Galassi, F., Kaman, W.E., Anssari Moin, D., Horst, J. van der, Wismeijer, D., Crielaard, W., Laine, M.L., Veerman, E.C.I., Bikker, F.J. & Loos, B.G. (2012). 2nd Prize for Graduate Research with article “Comparing culture, real‐time PCR and fluorescence resonance energy transfer technology for detection of Porphyromonas gingivalis in patients with or without peri‐implant infections”. Journal of Periodontal Research 2012; 47. EFP 2012, awarded by dr. Stefan Renvert, EFP secretary general March 2013. Goené, R.J. (2012, January 01). Honorary member. Nederlandse Vereniging voor Orale Implantologie: the Netherlands. Juffer, P. (2012, October 14). Young Investigator Award. American Society for Bone and Mineral Research: Minneapolis, MN, USA. Koutris, M. (2012, February 02 ‐ 2012, February 03). GSK‐IOT Best presentation award 2012: Overloading the masticatory muscles: pathophysiological and diagnostic considerations. IOT Dental Research Meeting: Lunteren, the Netherlands. Kuzmanova, D., Jansen, I.D.C., Schoenmaker, T., Nazmi, K., Teeuw, W.J., Bizzarro, S., Loos, B.G. & Velden, U. van der (2012). 3rd Prize for Graduate Research with article “Vitamin C in plasma and leucocytes in relation to periodontitis”. Journal of Clinical Periodontology 2012; 39. EFP 2012, awarded by dr. Stefan Renvert, EFP secretary general March 2013 . Oomens, M.A.E.M. (2012, November 02). Dento‐Alveolaire Scientific awards/honours 2012. Najaarsvergadering NVMKA: Noordwijk, the Netherlands. Organisation of international congresses and symposia Klein‐Nulend, J. (2012, September 26 ‐ 2012, September 28). Local organizer. EORS 2012 European Orthopaedic Research Society 20th Annual Meeting: ACTA building, Amsterdam, the Netherlands. Lobbezoo, F. (2012, January 13 ‐ 2012, January 14). Member Organizing Committee. 4th International Conference on Pain and Impaired Cognition: Leiden, the Netherlands. Lobbezoo, F. (2012, June 18 ‐ 2012, June 19). Member Organizing Committee. International Consensus Workshop “Expanded TMD taxonomy for further classification research”: Iguacu Falls, Brazil. Lobbezoo, F. & Wetselaar, P. (2012, May 11). Members Organizing Committee. International Tooth Wear Congress: “Scandinavia meets The Netherlands”: Lijnden, the Netherlands. 66 Academic Centre for Dentistry Amsterdam
Invited speakers at international congresses or symposia Aarab, G. (2012, August 29). Variability in the frequency of sleep disordered breathing. When is the effect of oral appliance therapy sufficient? Rome, Italy, World Congress on Sleep Apnea. Becking, A.G. (2012, May 09). 1. Condylar resorption in orthognathic surgery. 2. Planning en execution genioplasty. Kos, Greece, SORG Modular Course on maxillofacial surgery. Becking, A.G. (2012, November 17). Comprehensive diagnosis and management for unilateral condylar hyperplasia. Bali, Indonesia, Asian Conference on Oral and Maxillofacial Surgery. Becking, A.G. (2012, February 01). Comprehensive overview on diagnosis and treatment of condylar hyperplasia. Maspalomas, Gran Canaria, Spain, International Conference on Maxillfacial Surgery. Bruggenkate, C.M. ten (2012, November 23). Complications and risks. München, Germany, Course Implant Compl. Bruggenkate, C.M. ten (2012, April 27). Sinus Boden Elevation. Köln, Germany, Duits ITI Congres. Calcar, N.P. van (2012, March 08). Esthetic dentistry with composites. Gent, Belgium, Masterclass University of Gent. Everts, V. (2012, May 02). 1. New insights in bone remodeling. 2. Bone lining cells and osteoclast heterogeneity. Chengdu, China, Chengdu University School of Stomatology. Everts, V. (2012, May 10). Bone lining cells and osteoclast heterogeneity. Beijing, China, Peking University School of Stomatology. Everts, V. (2012, April 27). Bone lining cells and osteoclast heterogeneity. Wuhan, China, Wuhan University School of Stomatology. Everts, V. (2012, June 01). Bone remodeling, recent insights. Istanbul, Turkey, Yeditepe University, Dental Faculty. Everts, V. (2012, February 24). Osteopetrosis and the oc/oc mouse and osteoclast formation influenced by the substrate. Bangkok, Thailand, Chulalongkorn University, Faculty of Dentistry. Feilzer, A.J. (2012, April 18). Biomaterials in dentistry. Gent, Belgium, Masterclass University of Gent. Feilzer, A.J. (2012, November 12). Biomaterials in dentistry. Geneva, Switzerland, Masterclass University of Geneva. Goené, R.J. (2012, April 14). Mastering esthetics in post extraction sites. Portugal, Universidade de Lisboa. Goené, R.J. (2012, March 16). Mastering esthetics in post extraction sites. Paris, France, 7th Biomet/3i symposium. Goené, R.J. (2012, January 13). Mastering esthetics in post extraction sites. Madrid, Spain, European symposium. Goené, R.J. (2012, December 14). Mastering esthetics in post extraction sites, TEAMWORK: all of us know more than one of us. Istanbul, Turkey, Dental Institute Association, IDED, 3rd Int. Congress. Goené, R.J. (2012, December 01). New visions on implant risk and esthetic outcomes. Outcome of therapy. Genk, Belgium, Vlaamse Verbond van Tandartsen. Goené, R.J. (2012, April 13). Teamwork: all of us know more than one of us. Portugal, Universidade de Lisboa. Goené, R.J. (2012, September 21). The Impact of crestal bone preservation. Libanon, Beirut International Dental Meeting. Goené, R.J. (2012, June 08). The implant‐abutment interface. Vienna, Austria, European Federation of Periodontology. Hakman, E.C.J. (2012, September 20). Der Mund ist mehr als eine Kiste voller Zähne. Salzburg, Festvortrag Zahnärzte Kongress 2012. Hassan, B.A. (2012, December 08). Toepassingen van Cone Beam Computed Tomography in de tandartspraktijk. Brugge, Belgium, Vlaams Verbond voor Tandartsen wintersymposium. Klein‐Nulend, J. (2012, May 19). 1. NO signaling in mechanical adaptation of bone. 2. The role of osteocytes in mechanotransduction (meet the professor session). Stockholm, Sweden, European Calcified Tissue Society (ECTS), 39th Annual Congress. Klein‐Nulend, J. (2012, January 04). Bone adaptation and regeneration – new developments. 6th Jagna International Workshop: Mathematical Analysis, Modelling, and simulation in interdisciplinary sciences, Jagna, Bohol, Philippines. Klein‐Nulend, J. (2012, July 04). How our bones sense mechanical loading and transduce this information at the cellular level. London, UK, Seminar at Department of Bioengineering & Kennedy Institute of Rheumatology Division, Imperial College. 67 Annual Research Report 2012
Klein‐Nulend, J. (2012, June 24). Mechanical loading and how it affects bone cells. Davos Platz, Switzerland, European Cells and Materials meeting, eCM XIII, Bone Fixation, Repair & Regeneration (Focus CMF, Spine, Trauma). Klein‐Nulend, J. (2012, September 26). Mechanotransduction in bone. Cebu City, Philippines, San Carlos University, Dept. Physics. Klein‐Nulend, J. (2012, August 31). The osteocyte: the chief regulator of bone metabolism. Paris, France, Key lecture at 5th International Protelos Advisory Committee meeting (Servier). Klein‐Nulend, J. (2012, September 26). Translational research between dentistry & orthopaedics. Presidential guest lecture. Amsterdam, the Netherlands, European Orthopaedic Research Society 20th Annual Meeting. Kleverlaan, C.J. (2012, April 25). Biomaterials in dentistry. Gent, Belgium, Masterclass University of Gent. Kleverlaan, C.J. (2012, November 12). Biomaterials in dentistry. Geneva, Switzerland, Masterclass University of Geneva. Lange, J. de (2012, November 23). Literature evidence for a surgical and non‐surgical approach of condylar fractures. Rotterdam, the Netherlands, AOCMF Advanced Course. Liu, Y. (2012, May 01). Improvements for osteointegration. Hangzhou, China, Dental implant training course, (organized by TC medical group). Liu, Y. (2012, November 01). Large bone defect repair using biomimetic calcium phosphate granulars. Tainan, Taiwan, ABC123 Bioceramics. Liu, Y. (2012, November 02). Osteointegration in implant dentistry. Taipei, Taiway, Taiwan University. Lobbezoo, F. (2012, January 27). Are bruxism and the bite causally related? Nyborg, Denmark, Danish Society for Clinical Oral Physiology, Annual Meeting. Lobbezoo, F. (2012, July 22). Chewing on bruxism. Rhodes, Greece, 1st International Aegean Dental Congress. Lobbezoo, F. (2012, January 13). Orofacial aspects of dementia & impaired cognition. Leiden, The Netherlands, 4th International Conference on Pain and Impaired Cognition. Lobbezoo, F. (2012, November 30). À propos du bruxisme. Paris, France, Congrès Association Dentaire Française (ADF). Overman, J.R. (2012, November 20). Adipose stem cell application in sinus floor elevation. Hampton, VA, USA, Hampton University, School of Engineering & Technology, Department of Chemical Engineering. Stelt, P.F. van der (2012, September 06). Green Health. Mumbai, India. Stelt, P.F. van der (2012, April 14). Radiation protection and health safety regulations. Dubai, UAE. Tahmaseb, A. (2012, March 16). Guided surgery in implant dentistry. Hamburg, Germany, Dentsply World Congress, keynote address. Tahmaseb, A. (2012, January 02). Guided surgery in implant dentistry. Copenhagen, Horsens, ITI Study club Denmark. Tahmaseb, A. (2012, February 01). How guided is guided surgery. Chicago, USA, Midwinter meeting, Annual meeting American Academy of Prosthodontics, keynote address. Tahmaseb, A. (2012, November 01). How guided is guided surgery? New York, USA, Greater New Yorker Prosthodontics meeting, keynote address. Visscher, C.M. (2012, September 28). Aspects of accuracy of orthopaedic tests in dentistry. Amsterdam, the Netherlands, European Orthopaedic Research Society. Visscher, C.M. (2012, May 26). Orofacial physical therapy, when is it indicated? Luzern, Switzerland, Pain update 2012. Wismeijer, D. (2012, November 01). 1. Digitalisation in dentistry: where is all this taking us? 2. Loading protocols in implant dentistry: the quicker the better? South Africa, Congress of the South African Dental Association (SADA): “Dental Dignity for All”. Wismeijer, D. (2012, September 17). 1. The edentulous patient. 2. Peri‐implantitis. Hangzhou, China, Hangzhou University Dental Hospital Implant Forum. Wismeijer, D. (2012, October 13). 20 Years of implantology. What have we learned? Copenhagen, Denmark, European Association for Osseointegration (EAO), 21st annual scientific meeting. Wismeijer, D. (2012, September 06). Be prEPAred for your patient in the digital world. Rotterdam, the Netherlands, Opening Keynote speech, 36th Annual conference European Prosthodontic Association (EPA). Wismeijer, D. (2012, September 15). Implant dentistry in the digital world: Long‐term success, optimal outcome and the advanced technology. Taiwan, Taipei, Keynote speaker, 1st ITI congress, International Team for Implantology. Wismeijer, D. (2012, October 31). Implant related research at ACTA. Cape Town, South Africa, International Team for Implantology (ITI) combined Cape Town study clubs. 68 Academic Centre for Dentistry Amsterdam
Wismeijer, D. (2012, September 21). Long‐lasting clinical success and the advantages of digital dentistry. Peking, China, Keynote speaker, 75th anniversary congress, Peking University School of Stomatology. Wismeijer, D. (2012, February 06). The benefits of digital dentistry workflow for long‐lasting clinical success. Imagina, Monaco, Mediax 7‐9 Febr. 2012. The impact of digitalization in implant dentistry. Wismeijer, D. (2012, March 22). The digital workflow in implant dentistry. Antwerp, Belgium, 3e VBT congress Hilton. Wismeijer, D. (2012, April 20). The edentulous patient: The Dutch Approach. Denmark, Danish society for Oral Implantology. Supervisor of an external PhD student Bronckers, A.L.J.J. Everts, V.: Co‐supervisor of external PhD student D. Oortgiesen with thesis: "A tissue engineering approach to the regeneration of periodontal tissues" Supervisors: Prof.dr. J.A. Jansen and Prof.dr G.J. Meijer; co‐supervisor: Dr. X.F. Walboomers Radboud University Nijmegen, 24‐12‐2012. Supervisor of external PhD student K. Kanjanamekanant with thesis: "Roles of adenosine triphosphate (ATP) and gap junction hemichannels in mechanically‐
stimulated human periodontal ligament cells" Supervisor: Prof.dr. P. Pavasant Chulalongkron University, Bangkok, Thailand, 23‐11‐2012. Other international functions Aarab, G.: Berkhout, W.E.R.: Berkhout, W.E.R.: Berkhout, W.E.R.: Bruggenkate, C.M. ten: Feilzer, A.J.: Klein Nulend, J.: Kleverlaan, C.J.: Koutris, M.: Liu, Y.: Liu, Y.: Liu, Y.: Lobbezoo, F.: Lobbezoo, F.: Lobbezoo, F.: Lobbezoo, F.: Lobbezoo, F.: Lobbezoo, F.: Lobbezoo, F.: Sanderink, G.C.H.: Visscher, C.M.: Wismeijer, D.: Board member American Academy of Dental Sleep Medicine (AADSM). Member Research and Scientific Committee European Academy of Dento‐
Maxillo‐Facial Radiology (EADMFR). Member Central Council European Academy of Dento‐Maxillo‐Facial Radiology (EADMFR). Member Selection criteria and radiation protection committee European Academy of Dento‐Maxillo‐Facial Radiology (EADMFR). Member expert pool ITI/Straumann. Chairman ISO TC 106, SC2, WG 19. Founding member Micro‐mechanical Tissue Repair Society. Member ISO TC 106. Chair research committee European Academy of Craniomandibular Disorders (EACD). External reviewer AO foundation grant in the field of bone regeneration, biomaterials end dental implant. Honorary professor Hospital of Stomatology, Dental School of Zheijang University, Huangzhou, China. Scientific advisor maxillofacial surgery department University of Bern, Bern, Switserland. Member management committee EU‐COST Action TD‐1005 (Pain assessment in patients with impaired cognition, especially dementia). Member Grindcare Clinical Advisory Board (CAB), Medotech Denmark. President‐Elect International RDC/TMD Consortium Network, International Association of Dental Research (IADR). External examiner PhD thesis K.H. Bendixen, August 2012 University of Aarhus, Denmark. External examiner PhD thesis B. Craane, September 2012 University of Leuven, Belgium. External examiner PhD thesis N.N. Zhao, May 2012 University of Sydney, Australia. Member Working Group 1 “Psychometrics and Algesimetry”, EU‐COST Action TD‐
1005 (Pain assessment in patients with impaired cognition, especially dementia). Chairman Trustfund IADMFR. Board member Physical Therapy Board of Craniofacial and Cervical Therapeutics (PTBCCT), USA. Member Education Committee of the ITI (CH). 69 Annual Research Report 2012
Wismeijer, D.: Wismeijer, D.: Wismeijer, D.: Wismeijer, D.: Wismeijer, D.: Wismeijer, D.: Zandieh Doulabi, B.: Member Education Core group of the ITI (CH). Member Scientific Advisory Board (SAB) International Association of Digital Dentistry (IADD). Member Research Committee of the ITI. Examiner Royal College of Surgeons of Scotland. Honorary consultant Dental Clinic School of Stomatology, Zhejing Chinese Medical University. Honorary professor Zheijang University (China). Visiting professor Research Center for New Technologies in Life Sciences Engineering, University of Tehran, Iran. Societal impact The societal impact of the programme is evident by, among others, the impact on patient care, interactions with the industry and other non‐university groups, the impact on professionals, and relevant (inter‐)national functions. The research program also contributes to the post‐graduate training programs. The research on overloading and pain of the musculoskeletal structures of the masticatory system has direct impact on the quality of diagnostic procedures and of patient care, and extends its influence towards an improvement of the (oral‐) health‐related quality of life. The implications of this research are not only important for general orofacial pain patient groups, but also for more vulnerable populations like those suffering from dementias and otherwise impaired cognitive abilities. The BIOS research project has had its impact on the acceptation of the treatment of edentulous patients with oral implants by the Dutch Health Insurance companies. For edentulous patients, the treatment with two implants and an overdenture has been accepted as the treatment of choice for edentulous patients. The results of the research on bone adaptation and regeneration will offer multiple opportunities for the development of new therapeutic agents to prevent (inflammation‐associated) unwanted clinical bone loss, thereby preventing among others mobility loss with aging. An ambitious future goal of the program is to improve health care and treatment of patients with juvenile idiopathic arthritis. Diagnosis of arthritis of the jaw joint is commonly missed by clinicians, eventually possibly leading to progressive pain and malfunctioning of the joint. Research started in 2012 is focused on learning the biological parameters of the three types of cartilage present in the jaw joint. Inflammation will be mimicked in vitro and it will be determined whether mechanical loading will lead to a decreased inflammation. Special focus is on orthodontic patients with cranio‐facial deformities and/or related malocclusions. A program of quality of life related to this topic is carried out. The societal impact of the research on oral and maxillofacial radiology is focused on the improvement of diagnostic imaging procedures. This relates to not only technical parameters, but also other factors that influence the diagnostic performance of radio‐diagnostic procedures, such as the effect of viewing conditions and observer characteristics. Part of the activities includes continuing education courses on the safe use of radiation in dental practice and application of digital imaging in dentistry. Enamel fluorosis is an increasing aesthetic problem in several countries. The project on mechanism of enamel fluorosis adds to our understanding how these defects develop which will help to prevent these defects in future. The results of our research on bone adaptation and regeneration will offer multiple opportunities for the development of new therapeutic agents to prevent (inflammation‐associated) unwanted clinical bone loss, thereby preventing among others mobility loss with aging. The societal impact of the clinical research on oral and maxillofacial surgery is focussed on the influence on patient care, both within the department and externally. Research contributes to improved treatment of relevant patient groups. More details of the societal impact of the program are listed below. Interaction and collaborations with the industry and other non‐university groups Several scientists of the program have contacts with the industry, see the list of current grants in de paragraph of indicators of esteem above. 70 Academic Centre for Dentistry Amsterdam
Impact of the research on professionals Patients are referred by their dentists to the various specialized clinics of the departments participating in the program for diagnosis and treatment based on the latest scientific evidence. The guidelines for patient treatment related to the sub‐programme Oral and Maxillofacial Surgery were adopted by the Dutch Society for Oral and Maxillofacial Surgery. The guidelines for diagnosis and treatment of orofacial pain related to the sub‐
programme Oral Kinesiology were developed by the Dutch Society of Headache Patients. Several scientists of the program had interviews in Dutch dental Journals. A total of 40 professional publications were written. Membership of editorial board of national journals Calcar, N.P. van: Member Editorial Board. Praktijkboek Tandheelkunde. Dozic, A.: Member Editorial Board. Jaarboek Esthetische Tandheelkunde. Feilzer, A.J.: Member Editorial Board. Praktijkboek Tandheelkunde. Stelt, P.F. van der: Director Ned Tijdschrift voor Tandheelkunde BV (Dutch Dental Journal Inc). Lobbezoo, F.: Member of the advisory editorial board of “ACTA Quality Practice Organization of national congresses and symposia Everts, V.: Organisation of 2 day Conference in Woudschoten of the Dutch Society of Calcium and Bone Metabolism (November 2012). Roeters, F.J.M.: Falende restauraties: inzicht in valkuilen. Amsterdam, the Netherlands, 20‐04‐2012. Wismeijer, D.: 19 March 2012: ITI studyclub Veluwezoom. The Intraoral scanner for digital impression taking (Land goed Avegoor). Invited speakers at national congresses or symposia More than 28 presentations were given as invited speaker for professionals at congresses and symposia in the Netherlands by the following scientists: Aarab, G. Baart, J.A., Becking, A.G., Berkhout, W.E.R., ten Bruggenkate, C.M., van Calcar, N.P., Feilzer, A.J., Goene, R.J., Kleverlaan, C.J., de Lange, J., Lobbezoo, F., Visscher, C.M., Wetselaar, P., Wismeijer, D. Other national functions More than 24 memberships of national committees and advisory councils can be mentioned for the following individuals: Baart, J.A., Bruggenkate C.M. ten, Diermen, D.E. van, Everts, V., Feilzer, A.J., Goené, R.J., Klein‐
Nulend, J., Kleverlaan, C.J., Lobbezoo, F., Muris, J., Schulten, E.A.J.M., Stelt, P.F. van der, Visscher, C.M. Courses for dental and medical professionals More than 42 courses were given in the Netherlands for dentists, medical specialists and oral hygienists by the following scientists: Aarab, G., Baart, J.A., Berkhout, W.E.R., ten Bruggenkate, C.M., van Diermen, D.E., Forouzanfar, T., Goené, R.J., Lobbezoo, F., Sanderink, G.C.H., van der Stelt, P.F., Tahmaseb, A., Wismeijer, D. Lectures given during courses for dental and medical professionals in the Netherlands More than 47 presentations were given for dentists, medical specialists and oral hygienists in the Netherlands by the following scientists: Aarab, G., Baart, J.A., Becking, A.G., Berkhout, W.E.R., ten Bruggenkate, C.M., van Calcar, N.P., Feilzer, A.J., Forouzanfar, T., Goene, R.J., Kleverlaan, C.J., de Lange, J., Lobbezoo, F., Tahmaseb, A., Visscher, C.M., Wetselaar, P., Wismeijer, D. Collaborations -
Albert Schweitzer Ziekenhuis, Afdeling dermatologie, dr. R. Laeijendekker. AMOLF, Dr. G. Koenderink, Dr. R.G. Bacabac, Amsterdam, NL. Amsterdam Medical Center, Amsterdam, Prof. G. de Lange. the Netherlands. Biofarmind, The Hague, the Netherlands City University of New York, dr.ir. S.C. Cowin, New York, NY, USA. Clinical Research Department (dkf) , University of Bern, Bern, Switzerland. Crucell, Leiden, the Netherlands Department of Clinical Epidemiology and Biostatistics, VUmc, Amsterdam 71 Annual Research Report 2012
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72 Department of Clinical Genetics, VUmc, Amsterdam Department of Endocrinology, VUmc, Amsterdam Department of life sciences, Inner Mongolia Agriculture University, Huhehot, China. Department of maxillofacial surgery Prof. Dr. G. Juodzbalys., Lithuanian University of Health sciences. Department of MFP and Special Dental Care of the AMPHIA teaching hospital Breda (NL). Department of Nuclear Medicine and PET research, VUmc, Amsterdam Department of Nuclear Medicine and School of Dentistry, University of Nijmegen, the Netherlands: (Dr. Otto Bormen and Prof. J. Jansen) Department of oral and maxillofacial radiolog; prof. ME Parker., University of Western Cape, South Africa. Department of Oral and Maxillofacial Surgery, Leids Universitair Medisch Centrum, Leiden Department of Oral and Maxillofacial Surgery, Rijnland Ziekenhuis, Leiderdorp Department of Oral Surgery , University of Bern, Bern, Switzerland. (Daniel Buser) Department of Product & Process Engineering, DelftChemTech, Delft University of Technology Department of prosthodontics , University of Bern, Bern, Switzerland. (Urs Braegger) Department of prosthodontics , University of Zurich, Zurich, Switzerland. (Fraukje Muller) Department of restorative dentistry and biomaterial sciences. Harvard University, Boston USA (German Gallucci) Dipartimento di Medicina, Chirurgia e Odontoiatria – A.O. San Paolo, Università degli Studi di Milano. Matteo Chiapasco / Paolo Cassentini Ege University, Faculty of Medicine, Center for Brain Research & Department of Physiology, prof dr K. Türker, Bornova, Izmir, Turkey. Eindhoven University of Technology Dr ir H.A Reijers, Den Dolech 2, PO Box 513, 5600 MB, The Netherlands Eindhoven University of Technology, Department of Materials Technology (prof. dr. ir. J.M.J. den Toonder), Eindhoven, the Netherlands. Erasmus University Rotterdam, Prof. dr.ir. H. Weinans, Rotterdam, NL. Göteborg University, Sweden. Grethe Jonasson; a) Research & Development Unit in Southern Älvsborg County, Sweden; b) Research Center, Public Dental Service, Gothenburg, Sweden; c) Department of Orthodontics Göttingen University, Prof.dr. C.F. Schmidt, Göttingen, Germany Harvard University, Boston, MA, USA (Dr. R. Krishnan). Health Sciences University of Hokkaido, dr. M. Hashimoto, Hokkaido, Japan. Hiroshima University, Department of Orthodontics (dr. N. Kawai), Hiroshima, Japan. Hospital Hilversum, Dr. G.H.R. Albers, Hilversum, NL. Hospital of Stomatology, Dental School of ZheJiang University, Huangzhou, China. Imaging Sciences, prof. R. Jacobs, Katholieke Universiteit Leuven, Belgium. Institut für Anatomie, Zentrum für Experimentelle Medizin, Universitätsklinikum Hamburg‐Eppendorf, Hamburg, Germany Keele University, Prof.dr A. El Haj, Stoke‐on‐Trent, UK. King Saud University, dr. Z. Salameh, Riyadh, Saudi Arabia. Kyoto University, Prof.dr.ir T. Adachi, Dr. M. Tanaka, Kyoto, Japan. Kyushu University, Department of Oral and Maxillofacial Radiology (dr. T.K. Goto), Fukuoka, Japan. Margareta Ahlqwist; Department of Oral and Maxillofacial Radiology Institute of Odontology ‐ University of Gothenburg, Gothenburg, Sweden. Nordic Biosciences, Herlev, Denmark. Dr. K. Henriksen Okayama University, Dr. H. Kamioka, Okayama, Japan. Philippines, Cebu City, San Carlos University, Talamban Campus, Dr. R.G. Bacabac Radboud University Nijmegen, NL, Prof.dr. A.M. Kuijpers‐Jagtman, Dr. J.C. Maltha, Dr. R. van ‘t Hoff; Radboud University Nijmegen, Prof. dr. J. Jansen and Dr. X.F. Walboomers Regensburg University Medical Center, Department of Prosthetic Dentistry, Prof. dr. M Behr, Regensburg, Germany. Slotervaart General Hospital, Department of Clinical Neurophysiology and Brain Mapping Laboratory, dr H.L. Hamburger, Amsterdam, the Netherlands. Spaarne Hospital Heemstede, Dr. P.A. Nolte, Heemstede, NL. Straumann AG, Basel Zwitserland. R Willie head of Prosthodontics Techn. Univ. Eindhoven, Prof. M. Rauterberg UMCG (Prof.dr. R.A. Bank), Groningen, NL. Univ. Madrid, Spain, Prof. R. Marco. Academic Centre for Dentistry Amsterdam
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Univ. Milaan, Italy, Prof. S. Bradamante. Univ. of Connecticut, USA, M. Musgrave Universitair Medisch Centrum St. Radboud/Radboud Universiteit Nijmegen, Cariologie en Endodontologie, prof. dr M.C.D.N.J.M. Huysmans. Universiteit van Genève, Division of Cariology and Endodontology, prof. dr. I. Krejci, Genève, Swiss. University at Buffalo, Department of Oral Diagnostic Sciences, dr. R. Ohrbach, Buffalo (NY), USA. University of Aberdeen, UK, Prof. M. Helfrich University of Alexandria, Dental Biomaterials, dr. M.N. Aboushelib, Alexandria, Egypt. University of Cairo, Department of Operative Dentistry, dr. AA. El Zohairy, Cairo, Egypt University of California San Francisco (Prof DenBesten) University of Groningen, Department of Prosthodontics, Prof dr M.C. Cune, Prof Dr H Meijer Groningen, The Netherlands. University of Helsinki, Department of Stomatognathic Physiology & Prosthetic Dentistry, dr J. Ahlberg, Helsinki, Finland. University of Helsinki, Finland, Prof. K.Vaananen University of Kiel, Germany, Prof. P. Saftig University of Leuven, Dept Rheumatology, Prof.dr F. Luyten, Leuven, Belgium University of Naples, Department of Orthodontics ( I. Cioffi, dr. M. Farella), Naples, Italy. University of Navarra School of Medicine, Pamplona, Spain (Prof dr JF Medina) University of Nijmegen, Department of Prosthodontics, dr C Kreulen Nijmegen, The Netherlands University of Padova, TMD Clinic, dr D. Manfredini, Padova, Italy. University of São Paulo State (UNESP), Department of Dental Materials and Prosthodontics, F. Trindade, LF and Valandro, São Paulo, Brazil. University of Stockholm, Prof. G. Andersson University of Tanta, Department of Restorative Dentistry, dr. AI Abdalla, Tanta, Egypt. University of Tennessee, Clinical Research Center, dr. F. Garcia Godoy, Memphis, USA. University of Tokushima, Department of Orthodontics and Dentofacial Orthopedics (prof. E. Tanaka), Tokushima, Japan. University of Turku, Department of Prosthetic Dentistry and Biomaterials research, Prof. dr. Pekka Vallittu, Turku, Finland. University of Umea, Sweden, Prof. U. Lerner University of Zurich, Center for Dental and Oral Medicine, Dental Materials Unit, prof. dr. M. Özcan. UTHSC Dental School, Department of Restorative Dentistry, S. Wendt, San Antonio, Texas, USA. Utrecht University Medical Center, Dr. W.J.A. Dhert, Utrecht, NL. Vrije Universiteit, Department of Clinical Neuropsychology, prof.dr. E.J.A. Scherder, Amsterdam, the Netherlands. Vrije Universiteit, Nederlands Tweelingen Register (NTR), prof.dr. D.I. Boomsma, Amsterdam, the Netherlands. VU Amsterdam, Fact. Physics, D. Iannuzzi VUA, Dept Movement Sciences, Prof.dr. J. van Dieën, Prof.dr A. de Haan, Dr. R. Jaspers, Dr. K. Gerritsen, Amsterdam, NL. VUA, Dept Theoretical Physics (Prof.dr. F.C. MacKintosh), Amsterdam, NL. Vumc, Afdeling dermatologie, dr. Th. Rustemeyer. VUmc, Afdeling Pathologie, prof.dr. R.J. Scheper. VUMC, Dept Endocrinology, Prof dr. P. Lips, Dr. N. Bravenboer, Amsterdam, NL. VUMC, Dept Orthopaedics, Prof. Dr. B.J. van Royen, Dr. M.N. Helder, prof.dr.ir. T.H. Smit, Amsterdam, NL. VUMC, Dept Plastic Surgery (Prof.dr. M. Ritt, Dr. M.G. Mullender,), Amsterdam, NL. VUMC, Dept Rheumatology, Prof. Dr. W.F. Lems, Amsterdam, NL. VUmc, Laboratorium voor klinische immunologie, dr. M. von Blomberg. Zhejiang‐California Nano Systems Institute, Hangzhou, China Current PhD projects 2012 Alharbi, NM. Printing Ca‐phosphate with incorporated proteins in a construct to enhance bone in‐growth in critical size defects. Supervisor: prof.dr. D. Wismeijer; co‐supervisors: dr. Y.Liu and dr. A. Tahmaseb, start: October 2012. 73 Annual Research Report 2012
Apperloo, RC. Dental implants as anchorage for prostheses, number, configuration and suprastructure. Supervisor: prof. dr. J. de Lange, start: June 2010. Baas, EM. BSSO versus distraction osteogenesis of the mandible. Supervisor: prof.dr. J. de Lange, start: January 2007. Barbery, H el. Titanium‐allergy: a cause of oral implant failure? Supervisor: prof.dr. A.J. Feilzer, start: June 2009. Bergh, B van den. Epidemiology and treatment of mandibular trauma. Supervisor: dr. T. Forouzanfar, start: 2009. Blaauboer, ME. Myofibroblasts. Supervisors: prof.dr. V. Everts and prof.dr.ir. T.H. Smit; co‐supervisor: dr. R. Stoop, start: 2007. Bouwman, WF. Sinus floor elevation with bone and bone substitutes. Supervisors: prof.dr. C.M. ten Bruggenkate and prof.dr. E.A.J.M. Schulten; co‐supervisor: dr. N. Bravenboer, start 2008. Bronoosh P. Diagnostic value of Cone Beam CT for the assessment of erosive lesions of the TMJ. Supervisors: prof.dr. P.F. van der Stelt and prof.dr. F. Lobbezoo, start: September 2012. Chalil, S. Understanding muscle and bone anabolic resistance in ageing: is ER stress involved? Supervisor: prof.dr. P. Hespel and prof.dr. J. Klein‐Nulend; co‐supervisors: dr. A.D. Bakker and dr. R. Manders, start: 2012. Chen, C. Ceramic composite restorations. Supervisor: prof.dr. A.J. Feilzer, start: November 2009. Delwel, S. Oral health and orofacial pain in dementia. Supervisor: prof.dr. F. Lobbezoo, start: 2012. Derksen, WBC. The full digital workflow in dental implant treatment. Supervisor: prof.dr. D. Wismeijer; co‐
supervisor: dr. A. Tahmaseb, start: 2012. Dicker, GJFM. Muscular changes in orthognathic surgery. Supervisor: prof.dr. D.B. Tuinzing; co‐supervisors: dr. T. Forouzanfar and dr.ir. J.H. Koolstra, start: 2002. Diermen, DE van. Oral antithrombotics and dentistry: Current state of affairs and guideline proposal. Supervisor: prof.dr. I. van der Waal; co‐suprvisor: prof.dr. J. Hoogstraten, start: January 2007. Esterik, FAS van. Bioresorbable materials for scaffolds in oral in oral regenerative medicine. Supervisors: prof.dr. A.J. Feilzer, prof.dr. V. Everts and prof.dr. J. Klein Nulend; co‐supervisors: dr. C.J. Kleverlaan, dr. A.D. Bakker and dr.ir. R.F.M. van Oers, start: October 2012. Fazaeli, S. Structure and function of the temporomandibular disc: new challenges for tissue engineering. Supervisors: prof.dr. V. Everts and prof.dr.ir. T.H. Smit; co‐supervisor: dr.ir. J.H. Koolstra, start: October 2011. Fezari, S. Jaw joint. Supervisors: prof.dr. V. Everts and prof.dr.ir. T.H. Smit; co‐supervisor: dr.ir. J.H. Koolstra, start: 2012. Glim, JE. The role of macrophages in myofibroblast differentiation. Supervisors: prof.dr. R.H.J. Beelen and prof.dr. V. Everts; co‐supervisors: dr. F.B. Niessen and dr. M. van Egmond, start: 2010. Gooren, EE. Tissue engineering gingival for in vitro assays and risk assessment of dental materials. Supervisor: prof.dr. S. Gibbs, start: November 2012. Gregor, L. Low shrinkage dental composites. Supervisors: prof.dr A.J. Feilzer and prof.dr. I. Krejci, start: September 2008. Harkel ten, B. Multinucleated giant cells versus osteoclasts. Supervisor: prof.dr. V. Everts; co‐supervisor: dr.ir. T.J. de Vries, start: December 2011. Holmes, DB. Somatic and reprogrammed stem cells for treatment of bone growth disorders: epigenetic basis of cell identity and control. Supervisor: prof.dr. J. Klein Nulend; co‐supervisor: dr. G. Pals, start: October 2011. Ibrahim, N. Value of Cone Beam CT in assessment of bone quality. Supervisor: prof.dr. P.F. van der Stelt; co‐
supervisor: dr. B.A. Hassan, start: September 2010. Hoogeveen RC. Dose reduction in orthodontic radiography. Supervisor: prof.dr. P.F. van der Stelt; co‐
supervisors: dr. G.C.H. Sanderink and dr. W.E.R. Berkhout, start: 2012. Jaspers, GW. Medication in implant dentistry. Supervisor: prof.dr. J. de Lange, start: January 2011. Jong, T de. Tissue engineering of the periodontal ligament. Supervisor: prof.dr.ir. T.H. Smit, start: November 2012. Juffer, P. Biological pathways for regulation of muscle fiber size and bone mass. Supervisors: prof. dr. J. Klein‐
Nulend and prof. dr. P. Lips; co‐supervisors: dr. A.D. Bakker and dr. R. Jaspers, start: January 2009. Karssemakers, LHE. PET en SPEC scans in orofacial surgery. Supervisor: prof.dr. A.G. Becking, start: 2009. Khashayar, G. The science of tooth color. Supervisor prof.dr A.J. Feilzer, start October 2009. Koutris, M. Effects of delayed‐onset muscle soreness on the sensorimotor control of the masticatory system. Supervisors: prof.dr.ir. M. Naeije and prof.dr. F. Lobbezoo; co‐supervisor: dr. CM Visscher, start: 2007. 74 Academic Centre for Dentistry Amsterdam
Kommers, SC. Etiology and treatment of malocclusion after trauma. Supervisor: dr. T. Forouzanfar, start: 2011. Liu, T. Osteogenitic biomaterials for peri‐implantitis treatment. Supervisor: prof.dr. D. Wismeijer; co‐
supervisor: dr. Y.Liu, start: October 2009. Maningky, M.S. Implants in orofacial surgery. Supervisors: prof.dr. E.A.J.M Schulten and dr. T. Forouzanfar, start: 2012. Martin, WJJM. Diagnostic and treatment modalities in orofacial pain. Supervisors: prof.dr. D.B. Tuinzing and prof.dr. E.A.J.M. Schulten; co‐supervisor: T. Forouzanfar, start: 2009. Milheiro, A. Allergic reactions to dental nickel‐containing appliances. Supervisor: prof.dr. A.J. Feilzer; co‐
supervisor: dr. C.J. Kleverlaan, start: April 2009. Muris, J. Diagnostics of metal allergy associated with oral exposure. Supervisors: prof.dr. A.J. Feilzer & prof.dr. R.J. Scheper, start: September 2005. Muzalev, K. The relation between the type of bruxism and temporomandibular disorders. Supervisor: prof.dr. F. Lobbezoo; co‐supervisor: prof.dr.ir. M. Naeije, start: 2011. Nolte, JW. Distraction osteogenesis in orofacial surgery. Supervisor: prof.dr. A.G. Becking, start: 2011. Oomens, MAEM. Quality analysis of published research in maxillofacial surgery. Supervisor: dr. T. Forouzanfar, start: 2009. Ossendorp, R. Pain management after trauma surgery. Supervisor: dr. Forouzanfar and dr. F. Bloemen,start: 2011. Overman, JR. Bone augmentation with autologous mesenchymal stem cells from adipose tissue, BMP‐2, and calcium phosphate carrier materials in the sinusfloor elevation model. Supervisors: prof.dr J. Klein‐Nulend, prof.dr. E.A.J.M. Schulten and prof.dr C.M. ten Bruggenkate; co‐supervisor:, dr. M.N. Helder, start: November 2008. Parsa, A. Assessment of bone quality using CBCT; bone density. Supervisor: prof.dr. P.F. van der Stelt; co‐
supervisor: dr. B.A. Hassan, start: October 2010. Pathak, JL. The etiology of generalized osteoporosis in rheumatoid arthritis. Supervisors: prof.dr J. Klein‐
Nulend and prof.dr. F.P. Luyten; co‐supervisors: dr. A.D. Bakker and dr. N. Bravenboer, start: Ocober 2011. Renders, GAP. Consequences of mechanical interaction between cartilage and bone for development of osteoarthrosis. Supervisor: prof.dr. V. Everts; co‐supervisor: dr. G.E.J. Langenbach, start: September 2007. Rhee, AK van der. Scaffold molding by CAD‐CAM and targeting osteogenic differentiation of Mesenchymal stem cells by mechanical loading in a 3D environment: Implications for oral and maxillofacial bone defects. Supervisors: prof.dr. J. Klein‐Nulend and dr. C.J. Kleverlaan; co‐supervisors: dr. A.D. Bakker and dr. T. Forouzanfar, start: October 2011. Rollman, A. Chronic myogenous temporomandibular disorders: diagnostics, etiology and treatment. Supervisor: prof.dr.ir. M. Naeije; co‐supervisor: dr. C.M. Visscher, start: 2004. Rozeboom, AVJ. Treatment of fractures of the condylar head. A randomized clinical trial. Supervisor: prof. dr. J. de Lange, start: September 2011. Ruiter MHT de. Surgical treatment options for OSAS. Supervisor: prof.dr. J. de Lange, start: October 2012. Ruslin, M. Etiology of relapse after orthognatic surgery. Supervisor: prof.dr. D.B. Tuinzing; co‐supervisor: dr. T. Forouzanfar, start: 2011. Rutten, S. Effect of low intensity ultrasound on established delayed nonunion of the fibula, after a high tibial osteotomy. Supervisors: prof.dr. J. Klein Nulend and prof.dr. P.I.J.M. Wuisman †; co‐supervisor: dr. P.J. Nolte, start: 2005. Salentijn, E. Epidemiology and treatment of mandibular trauma. Supervisor: dr. T. Forouzanfar, start: 2011. Scholtanus, JC. Bonding to carious dentin. Supervisor: prof.dr. A.J. Feilzer, start: April 2009. Stoker, GT. BIOS‐2 The Breda implant overdenture Study part two. Comparing three different treatment modalities for implant supported overdentures. An eight year evaluation. Supervisor: prof.dr. D. Wismeijer, start: 2007. Tabeian, H. Osteoarthrose in the jaw joint. Supervisors: prof.dr. V. Everts and prof.dr. F. Lobbezoo; co‐
supervisors: dr. A.D. Bakker and dr.ir. T.J. de Vries, start: 2012. Tastepe, CS. Peri implant surface cleaning. Supervisor: prof.dr. D. Wismeijer;,co‐supervisor: dr. Y.Liu, start: April 2011. Tuijt, M. The role of muscle function on internal derangements of the TMJ. Supervisors: prof.dr.ir. M. Naeije and prof.dr. F. Lobbezoo; co‐supervisor: dr.ir. J.H. Koolstra, start: March 2007. Velzen, FJJ. van Risk factors and complications in oral and maxillofacial implantology. Supervisors: prof.dr. C.M. ten Bruggenkate and prof.dr. E.A.J.M. Schulten, start: 2010. Vermeer, AF. Diversity of osteoclasts. Supervisor: prof.dr. V. Everts; co‐supervisor: dr.ir. T.J. de Vries, start: January 2010. 75 Annual Research Report 2012
Vorselen, D. Mechanics at the (sub)‐cellular level. Supervisors: prof.dr.ir. G.J.L. Wuite and prof.dr. V. Everts; co‐supervisors: dr. J.J.W.A. van Loon and dr. W.H. Roos, start: June 2011. Wang, D. Antimicrobial bone substitute – Incorporation of antibiotics into BioCP for tretmant of bone loss caused by peri‐implantitis. Supervisor: prof.dr. D. Wismeijer; co‐supervisor: dr. Y. Liu, start: November 2012. Willems, HME. Combined effect of physical activity and nutrition on bone metabolism. Supervisor: prof.dr. J. Klein Nulend; co‐supervisor: dr. E. van den Heuvel, start: June 2007. Zande, MM van der. Digital dentistry in practice: On dentists’ interaction with technological transformation. Supervisor: prof.dr. D. Wismeijer; co‐supervisor: dr. R.C. Gorter, start: February 2012. 76 Academic Centre for Dentistry Amsterdam
Education related research, including other research Research on Dental Education Associate dean of educational research and development Dr. J.M. Vervoorn Education Institute ACTA, Gustav Mahlerlaan 3004 1081 LA Amsterdam Tel: +31‐20‐5980438 E‐mail: J.Vervoorn@acta.nl Research objectives In the ACTA faculty of Dentistry research is performed on several aspects of education in dentistry. This includes research on the evaluation of courses within the curriculum, research on new teaching methods, such as the Objective Structured Clinical Examination (OSCE), development and evaluation of a computer aided digital teaching system creating a virtual learning environment including the application of haptics (the Simodont Dental Trainer), and comparison with biomedical education elsewhere in Europe. The input of academic personnel is limited to staff of the educational institute, and to some members of the various departments. The research should not be considered as a separate programme; however it is intended that this research will increase in the coming years. Results In 2012 experiments have been carried out on training behaviour of students preparing for practical examinations. It appeared that behaviour of students shows a relationship with results of their examinations. Also it turned out that students who are in control of their program and deciding of testing moments performed better. The possibility to collect data on training behaviour in such a controlled environment offers the opportunity to compare performance of various groups of students even from separate universities using similar exercises. Academic personnel in 2012 and 2013 Research staff ACTA ‐ OWI and other research (in full time equivalents) Position Staff members education institute PhD students name Gorter, dr. R.C. Vervoorn, dr. J.M. Schoonheim‐Klein, dr. M.E. Schoonheim‐Klein, dr. M.E. Wesselink, prof.dr. P.R. Bakker, drs. D.R. Boer, drs. I.R. de Koopman, P. total 1st funding total 3rd funding Total research staff fte 2012 0,10 0,05 0,20 0,05 0,05 0,10 0,10 pm 0,30 plan 2013 pm 0,10 ‐‐ ‐‐ 0,10 0,15 0,20 0,15 ‐‐ funding 1 3 1 3 3 3 3 3 1 0,35 0,65 0,70 0,70 3 77 Annual Research Report 2012
Output Scientific publications (refereed) Kragelund, C., Reibel, J., Hietanen, J., Hadler‐Olsen, E., Johannessen, A.C., Kenrad, B., Nylander, K., Puranen, M., Salo, T., Syrjanen, S., Soland, T.M., Waal, I. van der, Wal, J.E. van der & Warfvinge, G. (2012). Scandinavian Fellowship for Oral Pathology and Oral Medicine: guidelines for oral pathology and oral medicine in the dental curriculum. European Journal of Dental Education, 16(4), 246‐253. Schoonheim‐Klein, M., Wesselink, P.R. & Vervoorn, J.M. (2012). A community of learners in the evidence‐
based dental clinic. European Journal of Dental Education, 16(1), e174‐e179. Schoonheim‐Klein, M., Gresnigt, C. & Velden, U. van der (2012). Influence of dental education in motivational interviewing on the efficacy of interventions for smoking cessation. European Journal of Dental Education, 17(1), e28‐e33. Schoonheim‐Klein, M.E. (2012). DVD review: feedback strategies in dental education DVD. European Journal of Dental Education, 16(3), 193. Professional publications Boer, I.R. de, Bakker, D.R., Wesselink, P.R. & Vervoorn, J.M. (2012). De Simodont in het onderwijs. Nederlands Tijdschrift voor Tandheelkunde, 119(6), 294‐300. Brand, H.S., Kharbanda, A., Kamell, H. & Dozic, A. (2012). De mening van tandheelkundestudenten over het onderwijs in kronen en bruggen. Nederlands Tijdschrift voor Tandheelkunde, 119, 626‐629. Brand, H.S. (2012). Tandheelkundestudenten en onderzoek. Nederlands Tijdschrift voor Tandheelkunde, 119(10), 459. Gorter, R.C. & Ong, T.S. (2012). Professioneel gedrag in het tandheelkundeonderwijs. Nederlands Tijdschrift voor Tandheelkunde, 119(6), 323‐327. Koopman, P. & Vervoorn, J.M. (2012). Onderwijsinnovaties voor de digitale student. Nederlands Tijdschrift voor Tandheelkunde, 119(6), 286‐290. Lobbezoo, F. & Kersten, H.W. (2012). Implantaten bij patiënten met bruxisme. Quality Practice. Nascholingstijdschrift voor mondhygiënisten, 4(4), 29‐36. Loveren, C. van (2011). De PICO‐vraag. Quality Practice. Nascholingstijdschrift voor tandartsen, 5(6), 28‐32. Schilder, I. & Hunnik, M. van (2012). Melding en preventie van prikaccidenten. Nederlands Tandartsenblad, 67(3), 20‐23. Schoonheim‐Klein, M.E., Selms, M.K.A. van, Volgenant, C.M.C., Wiegman, H.P. & Vervoorn, J.M. (2012). Het beoordelen van de klinische competenties van studenten tandheelkunde. Nederlands Tijdschrift voor Tandheelkunde, 119(6), 328‐336. Schoonheim‐Klein, M.E. (2012). Onderwijsvernieuwingen in opleidingen tandheelkunde. Nederlands Tijdschrift voor Tandheelkunde, 119(6), 271. Wort, P.A. van (2012). Medisch tandheelkundige interacties bij ACTA. Reactie op artikel Stegenga et al: Bespiegelingen over verantwoordelijkheid in de mondzorg. Nederlands Tijdschrift voor Tandheelkunde, 119(5), 237. Professional publications not included in the Annual Research Report 2011 Aartman, I.H.A. (2011). Kritisch beoordelen van gerandomiseerd gecontroleerd onderzoek. Quality Practice. Nascholingstijdschrift voor tandartsen, 6(5), 18‐21. Aartman, I.H.A. (2011). Niveaus van evidence: onderzoeksontwerpen. Quality Practice. Nascholingstijdschrift voor tandartsen, 6(5), 12‐16. Brand, H.S. (2011). Beeldvorming van tandartsen in films. Nederlands Tijdschrift voor Tandheelkunde, 118(7‐
8), 351. Dekker, J. den (2011). Mondzorg bij abonnement ‐ een illusie? Quality Practice. Nascholingstijdschrift voor mondhygiënisten, 4(2), 20‐23. Eijkman, M.A.J. (2010). De gebitsproblemen van de Zonnekoning Lodewijk XIV. Geschiedenis der Geneeskunde, 14(6), 336‐338. Eijkman, M.A.J. (2010). Koningin Elizabeth I en haar gebitsproblemen. Geschiedenis der Geneeskunde, 14(5), 291‐294. Eijkman, M.A.J. (2010). President George Washington en zijn kunstgebitten. Geschiedenis der Geneeskunde, 15(3), 140‐144. Eijkman, M.A.J. (2011). Informatie‐explosie? Nederlands Tijdschrift voor Tandheelkunde, 118(2), 59. 78 Academic Centre for Dentistry Amsterdam
Eijkman, M.A.J. (2011). Volledige gebitsprothesen: een inspanningsverbintenis! Nederlands Tijdschrift voor Tandheelkunde, 118(12), 617‐621. Eijkman, M.A.J., Hoekstra, G. & Ghahramani, M. (2011). Kaakchirurgische behandelingen als oorzaak van overlijden. Nederlands Tijdschrift voor Tandheelkunde, 118, 378‐381. Publications aimed for the general public Jongh, A. de (18‐01‐2012). Overigens. Het versoepelen van de eisen, zoals de TU Delft heeft gedaan, is een goede manier om studenten sneller te laten afstuderen. Folia Magazine, pp. 45. Indicators of Esteem Grants: current projects with external funding Wesselink P.R. & Vervoorn J.M. A grant of € 800.000,‐ (2008‐2010) was obtained from the Ministry of Education for ”Simodont, virtuele realiteit de werkelijkheid”. This grant was obtained together with the department of Preventive Dentistry Cariology Endodontology Pedodontology. This grant has been extended for unlimited time and finished in 2012. Membership of international editorial boards Gorter, R.C.: Associate editor European Journal of Dental Education. Other international functions Schoonheim‐Klein, M.E.: Chair Advisory committee the excellence in Dental Education Advisory Committee (EDEAC). Societal impact The societal impact of the research and development is focused on the effect of learning behaviour on learning outcomes and on the implementation of new technologies in education. This involves in particular the research on a computer aided digital learning environment (the Simodont dental trainer). Interactions and collaborations with the industry and other non‐university groups MOOG inc. Development of the Simodont dental trainer. Current PhD projects Bakker, D.R.: Transfer of skills between virtual reality and reality in dental education. Supervisors: prof.dr. P.R. Wesselink and dr. J.M. Vervoorn. Start 2010‐11. Boer de, IR.: Acceptance of new technologies in dental education. Supervisors: prof.dr. P.R. Wesselink and dr. J.M. Vervoorn. Start 2010‐11. Koopman, P.: Development and evaluation of an interactive learning environment for dental education. Supervisors: prof.dr. P.R. Wesselink and dr. J.M. Vervoorn. Start 2010‐11. 79 Annual Research Report 2012
Appendix 2012 List of SCI journals, their impact factors and the number of ACTA publications in 2012 in each journal Journal ACTA ODONTOL SCAND ALLERGY AM J PHYSIOL‐ENDOC M AMINO ACIDS ANAESTH INTENS CARE ANGLE ORTHOD ANN SURG ANTIMICROB AGENTS CH APPL ENVIRON MICROB ARCH IMMUNOL THER EX ARCH ORAL BIOL BBA‐BIOMEMBRANES BIOCHEM BIOPH RES CO BIOCHEM CELL BIOL BIOCHIMIE BIOINFORMATICS BMC GENOMICS BMC MICROBIOL BMC PUBLIC HEALTH BONE BONE MARROW TRANSPL BRIT DENT J BRIT J ORAL MAX SURG BRIT J PSYCHIAT BRIT J RADIOL CALCIFIED TISSUE INT CARBOHYD RES CARIES RES CELL ONCOL CELL TISSUE RES CLEFT PALATE‐CRAN J CLIN BIOMECH CLIN IMPLANT DENT R CLIN ORAL IMPLAN RES CLIN ORAL INVEST CLIN OTOLARYNGOL COMMUNITY DENT HLTH CONTACT DERMATITIS CYTOKINE GROWTH F R DENT MATER DENTOMAXILLOFAC RAD DEV NEUROREHABIL EUR CELLS MATER EUR J CANCER EUR J DENT EDUC EUR J NUTR EUR J ORAL SCI EUR J ORTHODONT FASEB J FUNGAL GENET BIOL HEAD NECK‐J SCI SPEC HEALTH QUAL LIFE OUT INT DENT J INT ENDOD J INT J ANTIMICROB AG INT J BIFURCAT CHAOS INT J DENT HYG 80 IF 1,066 6,271 4,746 3,248 1,279 1,207 7,492 4,841 3,829 2,541 1,603 3,990 2,484 2,673 3,022 5,468 4,073 3,044 1,997 4,023 3,746 0,915 1,950 6,619 1,314 2,376 2,332 2,328 3,105 3,114 0,822 2,071 3,532 2,514 2,364 2,393 0,753 3,509 7,812 3,135 1,081 1,577 3,028 5,536 1,183 2,750 1,878 0,893 5,712 3,737 2,403 2,112 0,963 2,179 4,128 0,755 0,871 Number of
publications
3
1
1
1
1
1
1
1
1
1
1
1
2
3
1
1
2
1
1
2
1
2
1
1
1
1
1
2
1
1
1
1
2
4
2
1
1
1
1
6
2
1
1
1
3
2
4
2
1
1
2
1
1
3
1
1
6
Journal
INT J ORAL MAX IMPL
INT J ORAL MAX SURG
INT J ORAL SCI
INT J PROSTHODONT
INTEGR BIOL‐UK
J BIOMAT SCI‐POLYM E
J BIOMED BIOTECHNOL
J BIOMED MATER RES B
J CELL BIOCHEM
J CELL PHYSIOL
J CLIN MICROBIOL
J CLIN PERIODONTOL
J CONTROL RELEASE
J CRANIO MAXILL SURG
J DENT
J DENT RES
J ENDODONT
J MATER SCI‐MATER M
J ORAL MAXIL SURG
J ORAL PATHOL MED
J ORAL REHABIL
J OROFAC PAIN
J PERIODONTAL RES
J PROSTHODONT
J TISSUE ENG REGEN M
J VET DENT
MED HYPOTHESES
MED ORAL PATOL ORAL
MICROBIOL‐SGM
MICROGRAVITY SCI TEC
MOL IMMUNOL
MUSCLE NERVE
NETH J MED
NEUROPHARMACOL
NUCL MED COMMUN
NUCLEIC ACIDS RES
ODONTOLOGY
ONCOLOGIST
OPER DENT
ORAL ONCOL
ORAL SURG ORAL MED O
OSTEOARTHR CARTILAGE
PERIODONTOL 2000
PHOTODIAGN PHOTODYN
PLOS ONE
QUAL LIFE RES
RADIAT ONCOL
RES VET SCI
SOC SCI MED
SOFT MATTER
STEROIDS
SUPPORT CARE CANCER
TISSUE ENG PART A
TISSUE ENG PART B REV
TISSUE ENG PART C METH
Z NEUROPSYCHOL
Total
IF Number of
publications
1,776 1,506 1,411 1,376 4,509 1,691 2,436 2,147 2,868 3,874 4,153 2,996 5,732 1,643 2,947 3,486 2,880 2,316 1,640 1,628 1,529 2,588 1,686 1,009 3,278 0,308 1,150 1,130 3,061 0,591 2,897 2,367 2,072 4,814 1,404 8,026 1,222 3,812 1,238 2,857 1,457 3,904 3,961 2,522 4,092 2,300 2,321 1,649 2,699 4,390 2,829 2,597 4,022 4,022 4,022 1,000 5
8
1
1
1
1
2
1
2
1
1
6
1
2
1
3
4
1
4
1
6
2
1
1
1
1
2
1
1
1
1
1
1
1
1
1
1
1
1
2
4
1
1
1
4
1
1
1
1
1
1
3
3
1
1
1
193
Academic Centre for Dentistry Amsterdam
Name Index Name Page Aartman, dr. I.H.A. Al Kurwi, A.S.A. Alfartousi, S. Algera, dr. T.J. Alharbi, dds.N.M. Allard, mr.dr. R.H.B. Alvarez Rodriquez, dds. E. Anssari Moin, D. Apperloo, drs. R.C. Arikan, msc. M. Ashton, dr. C.E. Atallah, drs. M.M. Baart, drs. J.A. Baas, drs. E.M. Bakker, dr. A.D. Barbery, dds. H. el Becking, prof.dr. A.G. Beek, prof.dr. H. van Benzian, dds. H. Bergh, drs. B. van den Berkhout, dr. W.E.R. Bikker, dr. F.J. Bizzarro, dds.msc. S. Blaauboer, drs. M.E. Bloemena, prof.dr. E. Boink, msc. M.A. Bolscher, dr. J.G.M. Bonifacio, dr. C.C. Bont, P. de Bos, dr. A. Bots, dr. C.P. Boutsioukis, dr. C. Bouwman, drs. W.F. Brand, dr. H.S. Brandt, dr. B.W. Broers, drs. D.L.M. Bronckers, dr. A.L.J.J. Bronoosh, P. Brouns, drs. E.R.E.A. Bruggenkate, prof.dr. C.M. ten Byraki, drs. A.A. Cate, prof.dr. J.M. ten Chalil, S. Chen, dds. C. Chin Jem Sen, drs. J. Crielaard, prof.dr. W. Cukkemane, msc. N. Dalen, dr. A., van Damaskos, dr. S. 19
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Name Page Dautovic, E. Dekker, dr. J. den Dekker, drs. H. Delwel, S. Deng, dr. D.M. Derksen, W.D.C. Diaz‐Serrano, dr. K. Dicker, dr. G.J.F.M. Dieleman, msc. A. Diermen, dr. D.E. van Dijk, drs. S., van Dijk, msc. I.A., van Disse, drs. M.A. Donders, drs. H.C.M. Dozic, dr. A. Dubois, drs. L. Duijster, drs. D. Duyx, drs. M.P.M.A. Eijkman, prof. dr. M.A.J. Elfrink, dr. M.E.C. Elmi, P. Esterik, msc. F.A.S. van Everts, prof.dr. V. Fabels, L.N.J. Faloni, drs. A.P. Faure, drs. E. Fazaeli, msc. S. Feilzer, prof.dr. A.J. Fernandez y Mostajo, msc. M. Fezari, S. Forouzanfar, dr. T. Gambon, dr. D.L. Geraets, dr. W.G.M. Geurs, N.C. Gibbs, prof.dr. S. Glim, J.E. Goené, drs. R.J. Gooren, msc. E.E. Gorter dr. R.C. Graven, drs. K.M.L. Gregor, dds. L. Groot, M. de Gunput, msc. S.T.G. Guo, J. Habets, dr. L.L.M.H. Hansenova Manaskova, msc. S. Harkel, msc. B. ten Hassan, dr. B.A. Helmers, drs. R. 20
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81 Annual Research Report 2012
Name Page Hermus, R.R. Hertog, drs. D. Holmes, msc. D.B. Hoogeveen, msc. R.C. Hoogstraten, prof.dr. J. Houtem, drs. C.M.H.H. van Hove, R. van Ibrahim, dds. N. Imangaliyev msc. S. Irshad, drs. M. Iskender, S.Y. Jager, dr. D.H.J. Jager, dr.ir. N., de Janus, ir. M.M. Jaspers, drs. G.W. Jiang, dds. L.M. Jong, msc. B.G. de Jong, msc. T. de Jongh, prof.dr. A. de Jong‐Lenters, drs. M. de Jongsma, dr. L.A. Joosten, M.W. Juffer, msc. P. Kaaij, drs. N.C.W. van der Kaiwar, A. Kaman ‐ van Zanten, ing. W.E. Karagozoglu, drs. K.H. Karssemakers, drs. L.H.E. Khashayar, drs. G. Klein Nulend, prof.dr. J. Kleverlaan, dr. C.J. Kommers, msc. S.C. Koning, M.J.W. Koolstra, dr.ir. J.H. Koopman, drs. J.E Korstjens, dr. C.M. Koutris, drs. M. Kramer, dr. G.J.C. Kraneveld, drs. E.A. Krikken, drs. J.B. Krom, dr. B.P. Kuitert, dr. R.B. Laheij, drs. A.M.G.A. Laine, dr. M.L. Lange prof.dr. J. de Langenbach, dr. G.E.J. Leito, ing. J.T.D. Liang, dds. Y.H. Ligtenberg, dr. A.J.M. Lindeboom, dr. J.A.H. Liu, dr. Y. 54
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82 Name Page Liu, drs. T. Lobbezoo, prof.dr. F. Loon, dr. J.J.W.A. van Loos, prof.dr. B.G. Louropoulou, dds. A. Loveren, prof.dr. C. van Macedo, dds. R.G. de Maningky, drs. M.S. Marpaung, drs. K. Martin, drs. W.J.J.M. Matse, msc. J.H. May, msc. A. Metska, dds. M.E. Mevissen‐Renckens, E.H.M. Milheiro, dds. A. Milstein, dr. D.M.J. Moghimi, drs. M. Moinzadeh, dds. A.T.M. Muris, drs. J. Muzalev, drs. K. Naeije, prof.dr.ir. M. Neelakantan, dds. P. Nicu, dr. E.A. Nolte, drs. J.W. Noverraz, drs. R.L.M. Oers, dr.ir. R.F.M. van Oomens, drs. M.A.E.M. Oosterhuis, M. Ossendorp, R. Overman, drs. J.R. Özok, dr. A.R. Papantonopoulos, dds. G.H. Paraskevas, dr. S.P. Parsa, dds. A. Parvaneh, drs. H. Parys, K. van Pathak, msc. J.L. Persoon, msc. I.F. Poorterman, dr. J.H.G. Prahl, dr. C. Prahl‐Andersen, prof.dr. B. Prins, dr. H‐J. Prodan, msc. A. Raber‐Durlacher, dr. J.E. Ramawadh, msc. R.S. Ramdat Missier, R.H. Reijden, dr. W.A. van der Renders, drs. G.A.P. Rhee, msc. A.K. van der Rijkschroeff, msc. P. Roeters, prof.dr. F.J.M. 56
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Academic Centre for Dentistry Amsterdam
Name Page Rollman, mw. A. Roos, C. de Rozeboom, drs. A.V.J. Rozema, prof.dr. F.R. Ruiter, drs. M.H.T. de Ruiz Zapata, A.M. Ruslin, dds. M. Rutten, S. Salentijn, drs. E. Sanderink, dr. G.C.H. Scheerman, msc. J.F.M. Scheres, dr. C.R. Scholtanus, drs. J.C. Schoonheim‐Klein, dr. M.E. Schreuder, W.H. Schulten, prof.dr. E.A.J.M. Selms, dr. M.K.A. van Shemesh, dr. H. Sijbrandij, drs. T. Sleen, drs. J. van der Slot, drs. D.E. Sluis, dr. L.W.M. van der Soet, dr. J.J. de Steenbergen, dr. T.J.M. van Stelt, prof.dr. P.F. van der Stoker, drs.ir. G.T. Strijp, dr. A.J.P. van Strydonck, dr. D.A.C. Van Suijkerbuijk, drs. E. Tabassum, dr. A. Tabeian, msc. H. Tahmaseb, dr. A. Tastepe, dds. C.S. Teeuw, msc. W.J. Tuijt, drs. M. Tuinzing, prof.dr. D.B. Tuk, J.C. Uijlenbroek, drs. H.J.J. Veen, dr.ir. M.H. van der 56
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Veerbeek, H.J. Veerkamp, dr. J.S.J. Veerman, prof.dr. E.C.I. Velden, prof.dr. U. van der Velzen, drs. F.J.J. van Verheij, dr. H.G.C. Vermaire, drs. J.H. Vermeer, msc. A.F. Vermeulen, F.M.J. Verrips, prof.dr. G.H.W. Verstraaten, mw. S. Vervoorn‐Vis, drs. G. Visscher, dr. C.M. Vleugel, B. van der Volgenant, drs. C.M.C. Vorselen, msc D. Vries, dr.ir. T.J. de Vries, L. de Waal, drs. S.V. van der Waal, prof.dr. I. van der Wan, Q. Wang, dds. D. Weijden, prof.dr. G.A. van der Weijers, dr. M. Wesselink, prof.dr. P.R. Wetselaar, drs. P. Wijk, dr. A.J. van Willems, drs. H.M.E. Wismeijer, prof.dr. D. Wu, dr. G. Wu, dr. M.K. Zande, msc. M.M. van der Zandieh Doulabi, dr.ing. B. Zaura, dr. E. Zecha, drs. J.A.E.M. Zembic, dds. A. Zentner, prof.dr. A. Zygogiannis, dds. K. 83