Per Alstergren: The temporomandibular joint. Oral Neuroscience Course 2010 Utredning av ansiktssmärta 2014-03-04 Diagnostic Criteria - Problems • • • • • Biobehavioral pain model Reliability Validity Operationalization Clinical relevance-treatment and prognosis Most classification systems: one axis – one focus – muscle or joint pain Thomas List Arne Petersson Malmö University | Thomas List och Arne Petersson 2014-03-04 Comprises: A dual axis approach. • Clinical TMD Conditions (Axis I) • Psychological disorders and psychosocial dysfunction (Axis II) Specifications for TMD Examination. Strict diagnostic criteria. Malmö University | Thomas List och Arne Petersson 2014-03-04 Malmö University | Thomas List och Arne Petersson 2014-03-04 Major steps from the RDC/TMD to the DC/TMD Research Diagnostic Criteria for TMD (RDC/TMD) RDC/TMD Malmö University | Thomas List och Arne Petersson 2014-03-04 Year Event 1992 Publication of RDC/TMD 2001-2008 Validation Project 2008 Symposium at IADR Conference (Toronto) 2009 International RDC/TMD Consensus Workshop at IADR Conference (Miami) 2010 Publication of Major findings by Validation Project 2010 Symposium at IADR Conference (Barcelona) 2011 International RDC/TMD Consensus Workshop at IADR Conference (San Diego). Expanded Taxonomy of DC/TMD 2012 Symposium of DC/TMD Conference at at IADR Conference (Iguacu Falls). Expanded Taxonomy of DC/TMD 2013 Finalization of Expanded Taxonomy of DC/TMD at IADR Conference (Seattle) 2014 Publication of DC/TMD and Expanded taxonomy of TMD 2014 Symposium of Expanded taxonomy of TMD at IADR Conference (Cape Town). Malmö University | Thomas List och Arne Petersson 2014-03-04 1 Per Alstergren: The temporomandibular joint. Oral Neuroscience Course 2010 IADR Miami 2009 Description of the Workshop International Consensus Workshop: Convergence on an Orofacial Pain Taxonomy • • Workshop participation: • • • • • International RDC/TMD Consortium Network SIG Orofacial Pain NIDCR American Academy of Orofacial Pain European Academy of Craniomandibular Disorders • International Headache Society • Other disciplines included: radiology, psychology, ontology, neurology and patient advocacy. Malmö University | Thomas List och Arne Petersson 2014-03-04 • • • 2014-03-04 Presentations: Systematic review guidelines, biomedical ontology and patient advocacy. Workgroup made revisions of respective parts of the RDC/TMD Each workgroup presented the recommendations for critique by the others. Delphi-like voting for determing whether sufficient concensus had been achieved. Malmö University | Thomas List och Arne Petersson 2014-03-04 Expanding the Scope of the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) Alla tillstånd Represented Organizations • Expanded taxonomy 2014-03-04 Expanded Taxonomy for Temporomandibular Disorders Peck et al. J Oral Rehab 2014; 41: 2-23. IADR San Diego 2011 Diagnostik Malmö University | Thomas List och Arne Petersson • • • • • International RDC/TMD Consortium Network IASP Orofacial Pain SIG American Academy of Orofacial Pain European Academy of Craniomandibular Disorders International Headache Society National Institute of Dental and Craniofacial Research I. TEMPOROMANDIBULAR JOINT DISORDERS 1 Joint pain A Arthralgia B Arthritis 2 Joint disorders A Disc disorders 1 Disc displacement with reduction 2 Disc displacement with reduction with intermittent locking 3 Disc displacement without reduction with limited opening 4 Disc displacement without reduction without limited opening B Hypomobility disorders other than disc disorders 1 Adhesions/Adherence 2 Ankylosis a Fibrous b Osseous C Hypermobility disorders 1 Dislocations a Subluxation b Luxation MALMÖ HÖGSKOLA Malmö högskola | Orofaciala smärtenheten | Per Alstergren 2014-03-04 2 Per Alstergren: The temporomandibular joint. Oral Neuroscience Course 2010 2014-03-04 Expanded Taxonomy for Temporomandibular Disorders Peck et al. J Oral Rehab 2014; 41: 2-23. 3 Joint diseases A Degenerative joint disease 1 Osteoarthrosis 2 Osteoarthritis B Systemic arthritides C Condylysis/Idiopathic condyle resorption D Osteochondritis dissecans E Osteonecrosis F Neoplasm G Synovial chondromatosis 4 Fractures 5 Congenital/developmental disorders A Aplasia B Hypoplasia C Hyperplasia II. MASTICATORY MUSCLE DISORDERS III. HEADACHE IV. ASSOCIATED STRUCTURES 1 Coronoid hyperplasia Pain and headache location DC/TMD Questionnaire ”Pain during the last 30 days” Symptom questionnaire Pain intensity Limitation in daily activities Jaw function Psychosocial health Pain drawing Demographics MALMÖ HÖGSKOLA Malmö University | Thomas List och Arne Petersson 2014-03-04 Kalibrering Maximum unassisted opening: Decision trees ”I would like you to open your mouth as wide as you can, even if it is painful” Pain Familiar Pain Temporalis N Y N Y Masseter N Y N Y TMJ N Y N Y Other M Musc N Y N Y Non-mast N Y N Y Malmö University | Thomas List och Arne Petersson Familiar Headache N Y 2014-03-04 Malmö University | Thomas List och Arne Petersson 2014-03-04 Malmö University | Thomas List och Arne Petersson 2014-03-04 3 Per Alstergren: The temporomandibular joint. Oral Neuroscience Course 2010 2014-03-04 Expanded Taxonomy for Temporomandibular Disorders Peck et al. J Oral Rehab 2014; 41: 2-23. Myalgia I. TEMPOROMANDIBULAR JOINT DISORDERS 1 Joint pain A Arthralgia B Arthritis 2 Joint disorders A Disc disorders 1 Disc displacement with reduction 2 Disc displacement with reduction with intermittent locking 3 Disc displacement without reduction with limited opening 4 Disc displacement without reduction without limited opening B Hypomobility disorders other than disc disorders 1 Adhesions/Adherence 2 Ankylosis a Fibrous b Osseous C Hypermobility disorders 1 Dislocations a Subluxation b Luxation Sensitivity 0.84; Specificity 0.95 History: 1. Pain in the jaw, temple, in the ear, or in front of ear; AND 2. Pain modified with jawe movement, function or parafunction. AND Exam: 1. Confirmation of pain location in the area of the temporalis or masseteer muscle(s); AND 2. Report of familiar pain in the temporalis or masseter with at least 1 of the following provocation tests: a. Palpation of the temporalis or masseter muscles(s); OR b. Maximum unassisted or assisted opening. Arthralgia Sensitivity 0.91; Specificity 0.96 History: 1. Pain in the jaw, temple, in the ear, or in front of ear; AND 2. Pain modified with jaw movement, function or parafunction. AND Exam: 1. Confirmation of pain location in the area of the TMJ(s); AND 2. Report of familiar pain in the TMJ with at least 1 one of the following provocation tests: a. Palpation ofthe lateral pole; OR b. Maximum unassisted or assisted opening, right or left lateral movements, or protrusive movements. MALMÖ HÖGSKOLA Malmö University | Thomas List och Arne Petersson 2014-03-04 Malmö University | Thomas List och Arne Petersson 2014-03-04 Expanded Taxonomy for Temporomandibular Disorders Peck et al. J Oral Rehab 2014; 41: 2-23. Palpation TMJ joint TMJ Pain Lateral pole (0,5 kg) Malmö University | Thomas List och Arne Petersson Familiar Pain Referred Pain N Y N Y N Around lateral pole (1kg) N Y N Y N Y Y I. TEMPOROMANDIBULAR JOINT DISORDERS 1 Joint pain A Arthralgia B Arthritis 2 Joint disorders A Disc disorders 1 Disc displacement with reduction 2 Disc displacement with reduction with intermittent locking 3 Disc displacement without reduction with limited opening 4 Disc displacement without reduction without limited opening B Hypomobility disorders other than disc disorders 1 Adhesions/Adherence 2 Ankylosis a Fibrous b Osseous C Hypermobility disorders 1 Dislocations a Subluxation b Luxation MALMÖ HÖGSKOLA Disc Displacement with Reduction (Sensitivity 0.80; specificity 0.97 without imaging) History is positive for at least one of the following: 1. In the last 30 days, any TMJ noises(s)present with jaw movements or function; OR 2. Patient report of any noise present during exam; AND Examination is positive at least for one of the following: 1. Clicking popping, and/or snapping noise detected during both opening and closing movements, detected by palpation during at least one of three repetitions of jaw opening and closing movements; OR 2a. Clicking popping, and/ or snapping noise detected with palpation during at least one of three repetitions of opening and closing movements(s);AND 2b. Clicking popping, and/ or snapping noise detected with palpation during at least one of three repetitions of right and left lateral or protrusive movement(s). 2014-03-04 4 Per Alstergren: The temporomandibular joint. Oral Neuroscience Course 2010 Disc Displacement without Reduction with Limited Opening (DC/TMD) (Sensitivity 0.80; specificity 0.97 without imaging) 2014-03-04 Normal disc position closed mouth sagittal and coronal views (Ahmad et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod DISC DISORDERS 2009;107:844-860) Imaging: Diagnostic imaging should only be considered after a history and physical examination, indicates that information from imaging will influence patient care. Further research is needed. I. History is positive for both of the following: 1. Jaw lock or catch so that it would not open all the way; AND 2. Limitation in jaw opening severe enough to interfere with ability to eat. AND II. Examination is positive for the following: 1.Maximum assisted opening (passive stretch) < 40mm. Including vertical incisal overlap. MRI is the prefered modality Peck et al. 2014 MALMÖ HÖGSKOLA i. In the sagittal plane, relative to the superior aspect of the condyle, the border between the low signal of the disc and the high signal of the retrodiscal tissue is located between the 11:30 and 12:30 clock positions; and ii. In the sagittal plane, the intermediate zone is located between the anterior-superior aspect of the condyle and the posterior-inferior aspect of the articular eminence; and iii. In the oblique coronal plane, the disc is centered between the condyle and eminence in the medial, central, and lateral parts. MALMÖ HÖGSKOLA Disc displacement Proton density, Sagittal, Closed mouth Normal disc position T2 (Ahmad et al. 2009) Proton density Coronal Closed mouth Westesson 1982 i. In the sagittal plane, relative to the superior aspect of the condyle, the low signal of the disc and the high signal of the retrodiscal tissue are located anterior to the 12:30 clock position; and ii. In the sagittal plane, the intermediate zone of the disc is located anterior to the condyle; or iii. In the axially corrected coronal plane, the disc is not centered between the condyle and eminence in either the medial or the lateral parts. MALMÖ HÖGSKOLA 5 Per Alstergren: The temporomandibular joint. Oral Neuroscience Course 2010 Closed mouth Disc displacement Proton density, Coronal 2014-03-04 T2 Disc position: open-mouth sagittal views Closed mouth (Ahmad et al. 2009) Lateral disc displacement Normal disc position: The intermediate zone is located between the condyle and the articular eminence. Persistent disc displacement: The intermediate zone is located anterior to the condylar head. MALMÖ HÖGSKOLA Proton density Sagittal Open mouth Normal disc position Closed mouth Disc displacement Open mouth Without reduction Disc diagnosis for TMJ (Ahmad et al. 2009) A. Normal: Disc location is normal on closed- and open-mouth images. B. Disc displacement with reduction: Disc location is displaced on closed-mouth images but normal in open-mouth images. C. Disc displacement without reduction: Disc location is displaced on closed-mouth and openmouth images. D. Indeterminate: Disc location is not clearly normal or displaced in the closed-mouth position. E. Disc not visible MALMÖ HÖGSKOLA 6 Per Alstergren: The temporomandibular joint. Oral Neuroscience Course 2010 MRT MRI 1.5 - 3 Tesla Axially corrected sagittal and coronal images Closed and open mouth positions Proton-density PD or T1, and T2 MALMÖ HÖGSKOLA Proton density T2 1. Diskens läge 2. Diskens form Normal: Bikonkav i sagitalplanet Deformerad: Alla andra former än bikonkav Disk går ej att identifiera 3. Effusion-ledvätska Ingen: Ingen förhöjd signal i ledrummen vid T2-viktade bilder Lätt (slight) effusion: En förhöjd signal i något av ledrummen som håller sig längs konturerna av disken, fossa, tuberkeln eller condylen Kraftig (frank) effusion: En förhöjd signal i något av ledrummen som sträcker sig utanför de osseösa konturerna av fossa, tuberkeln, condylen och som har en konvex konfiguration I den anteriora eller posteriora recessen 4. Förkalkningar i leden 5. Osseösa förändringar (erosion, osteofyt, subchondral cysta, avplaning) 6. Benmärgsförändringar (ödem, scleros) MALMÖ HÖGSKOLA The Efficacy of Diagnostic Imaging Fryback & Thornbury (1991) 6 TMJ disc position 5 Societal 3 Patient outcome 2 Therapeutic 1 Diagnostic thinking Diagnostic accuracy Technical TMJ disc position (Limchaichana et al. 2006) 4 Efficacy levels MALMÖ HÖGSKOLA 2014-03-04 Sensitivity and specificity 7 publications moderate and 7 low levels of evidence. Diagnostic criteria and disease prevalences varied substantially. Sagittal images: sensitivity 0.86, specificity 0.63 Coronal images: sensitivity 0.50-0.87, specificity 0.800.92 Combining sagittal and coronal images: sensitivity 0.60-0.90, specificity 0.92-1.0 MALMÖ HÖGSKOLA Observer performance (Limchaichana et al. 2006) 4 publications with moderate level of evidence Intraobserver agreement Kappa mean, 0.85 good Interobserver agreement very good for high quality images and disk displacement without reduction (Kappa 0.91), and poor for slight anterior disk displacement (Kappa 0.19). Interobserver agreement - Kappa; (Ahmad et al. 2009) Any disc displacement 0.84 Disc displacement with reduction 0.78 Disc displacement without reduction 0.94 MALMÖ HÖGSKOLA 7 Per Alstergren: The temporomandibular joint. Oral Neuroscience Course 2010 Web-based calibration of observers using MRI of the temporomandibular joint The efficacy of magnetic resonance imaging in the diagnosis of degenerative and inflammatory temporomandibular joint disorders: a systematic literature review. Hellén-Halme, Hollender, Janda, Petersson. Dentomaxillofac Radiol 2012; 41, 656–661. Limchaichana et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;102:521-36. http://www.mah.se/od/rad/tmj MALMÖ HÖGSKOLA • No publication had a high level of evidence • No publication reported diagnostic thinking efficacy or therapeutic efficacy • The evidence grade for diagnostic accuracy expressed as sensitivity, specificity, and predictive values was limited to insufficient MALMÖ HÖGSKOLA Expanded Taxonomy for Temporomandibular Disorders Peck et al. J Oral Rehab 2014; 41: 2-23. Degenerative joint disease (Sensitivity 0.55; specificity 0.61 without imaging) I. History is positive for at least one of the following: 1. In the last 30 days, any TMJ noises(s)present with jaw movements or function; OR 2. Patient report of any noise present during exam. AND II. Examination is positive at least for one of the following: 1. Crepitus detected with palpation during at least one of the following; opening, closing, right or left lateral or protrusive movements (s). Degenerative joint disease (DJD) • Deterioration of articular tissue with osseous changes. DJD can be sub-classified as: Osteoarthrosis - DJD without arthralgia Osteoarthritis – DJD with arthralgia • Flattening and and /or subcortical sclerosis are considered indeterminant findings for DJD and may represent normal variation, aging, remodelling or a precursor to frank DJD. Imaging: When this diagnosis needs to be confirmed. TMJ CT/CBCT criteria are positive for at least one of the following: 1. Subchondral cyst 2. Erosion(s) 3. Generalized sclerosis 4. Osteophyte(s) MALMÖ HÖGSKOLA 2014-03-04 Expanded Taxonomy for Temporomandibular Disorders Peck et al. J Oral Rehab 2014; 41: 2-23. 3 Joint diseases A Degenerative joint disease 1 Osteoarthrosis 2 Osteoarthritis B Systemic arthritides C Condylysis/Idiopathic condyle resorption D Osteochondritis dissecans E Osteonecrosis F Neoplasm G Synovial chondromatosis 4 Fractures 5 Congenital/developmental disorders A Aplasia B Hypoplasia C Hyperplasia II. MASTICATORY MUSCLE DISORDERS III. HEADACHE IV. ASSOCIATED STRUCTURES 1 Coronoid hyperplasia MALMÖ HÖGSKOLA Osseous diagnoses. Ahmad et al. 2009 A. No osteoarthritis i. Normal relative size of the condylar head; and ii. No subcortical sclerosis or articular surface flattening; and iii. No deformation due to subcortical cyst, surface erosion, osteophyte, or generalized sclerosis. B. Indeterminate for osteoarthritis i. Normal relative size of the condylar head; and ii. Subcortical sclerosis with/without articular surface flattening; or iii. Articular surface flattening with/without subcortical sclerosis; and iv. No deformation due to subcortical cyst, surface erosion, osteophyte, or generalized sclerosis. C. Osteoarthritis i. Deformation due to subcortical cyst, surface erosion, osteophyte, or generalized sclerosis. MALMÖ HÖGSKOLA 8 Per Alstergren: The temporomandibular joint. Oral Neuroscience Course 2010 2014-03-04 Osseous changes. Diagnostic accuracy. CBCT of condyle. Hintze et al. 2007 Sensitivity Lateral Frontal Specificity Lateral Frontal Flattening 0,23 0,40 0,87 0,90 Defect 0,15 0,20 0,95 0,96 Osteophyte 0,15 Honda et al. 2006 0,96 0,80 • To test changes in diagnosis and management after radiographic examination • To evaluate the associations between specific findings in TMJ tomograms and changes in management strategy. Ahmad et al. 2009 Kappa Panoramic radiography 0.27 MRI 0.58 CT 0.71 1,0 MALMÖ HÖGSKOLA Hur påverkas diagnos och behandlingsval av röntgenfynden vid TMD? Osseous changes. Observer agreement. MALMÖ HÖGSKOLA Diagnostic thinking Therapeutic thinking The diagnosis (RDC/TMD) was changed in 27% of the patients after tomography, often arthralgia > osteoarthritis Choice of treatment with and without tomography. 3 clinics. The choice of treatment was changed in 27% of the patients – mostly slight changes in medication and fysiotherapy. Wiese 2008 Differences existed between the clinics MALMÖ HÖGSKOLA MALMÖ HÖGSKOLA MALMÖ HÖGSKOLA Wiese 2008 9 Per Alstergren: The temporomandibular joint. Oral Neuroscience Course 2010 2014-03-04 Expanded Taxonomy for Temporomandibular Disorders Peck et al. J Oral Rehab 2014; 41: 2-23. 3 Joint diseases A Degenerative joint disease 1 Osteoarthrosis 2 Osteoarthritis B Systemic arthritides C Condylysis/Idiopathic condyle resorption D Osteochondritis dissecans E Osteonecrosis F Neoplasm G Synovial chondromatosis 4 Fractures 5 Congenital/developmental disorders A Aplasia B Hypoplasia C Hyperplasia II. MASTICATORY MUSCLE DISORDERS III. HEADACHE IV. ASSOCIATED STRUCTURES 1 Coronoid hyperplasia Systemic arthritides Systemic Arthritides Note that imaging in early stages of the disease may not demonstrate any osseous findings. History positive for both of the following: 1. Rheumatic diagnosis of a systematic inflammatory joint disease, AND 2a. Pain in the jaw, temple, in the ear, or in front of ear; AND 2b. Pain modified with jaw movement, function or parafunction; AND Imaging If osseous changes are present, TMJ CT/CBCT or MR imaging is positive for at least one of the following: 1. Subchondral cyst(s) 2. Erosion(s) 3. Generalized sclerosis 4. Osteophyte(s) Examination positive for both of the following 1. Rheumatic diagnosis of a systematic joint disease; AND 2a. Arthritis signs and symptoms as deined in I.1.B; OR 2b. Crepitus detected with palpation during maximum unassisted opening, maximum assisted opening, right or left lateral movements, or protrusive movements. MALMÖ HÖGSKOLA MALMÖ HÖGSKOLA Malmö University | Thomas List och Arne Petersson 2014-03-04 Expanded Taxonomy for Temporomandibular Disorders Peck et al. J Oral Rehab 2014; 41: 2-23. Åkerman et al. (1991). Nittio patienter med RA. 2/3 uppvisade röntgenförändringar i käklederna, oftast erosioner jämförbara med förändringarna i händer och fötter. 3 Joint diseases A Degenerative joint disease 1 Osteoarthrosis 2 Osteoarthritis B Systemic arthritides C Condylysis/Idiopathic condyle resorption D Osteochondritis dissecans E Osteonecrosis F Neoplasm G Synovial chondromatosis 4 Fractures 5 Congenital/developmental disorders A Aplasia B Hypoplasia C Hyperplasia II. MASTICATORY MUSCLE DISORDERS III. HEADACHE IV. ASSOCIATED STRUCTURES 1 Coronoid hyperplasia MALMÖ HÖGSKOLA 10 Per Alstergren: The temporomandibular joint. Oral Neuroscience Course 2010 Synovial chondromatosis SBU: Synovial chondromatos är en benign sjukdom som innebär att ledhinnan i käkleden bildar fria broskkroppar. Tillståndet behandlas t ex med käkledkirurgi. Socialstyrelsen: Tillståndet innebär en mycket stor påverkan på den orala hälsan till följd av en stor grad av vävnadsskada 2014-03-04 Synovial chondromatosis Synovial Chondromatosis Imaging: TMJ MRI or CT/CBCT is positive for at least one of the following: 1. MRI: multiple chondroid nodules, joint effusion and amorphous iso-intensity signal tissues within the joint space and capsule 2. CT/CBCT: loose calcified bodies in the soft tissues of the TMJ History positive for at least one of the following: 1. Report of preauricular swelling; OR 2. Arthralgia as defined in I.1.A; OR 3.Progressive limitation in mouth opening; OR 4. In the past month, any joint noise(s) present II. Examination positive for at least one of the following: 1. Preauricular swelling; OR 2. Arthralgia as defined in I.1.A; OR 3. Maximum assisted opening< 40 mm including vertical overlap; OR 4. Crepitus as per I3.A (DJD) MALMÖ HÖGSKOLA MALMÖ HÖGSKOLA Malmö University | Thomas List och Arne Petersson 2014-03-04 Synovial chondromatos Synovial chondromatos Case Arne has pain in the first molar in his upper left jaw. Tooth 27 was extracted by another dentist because of a crack. Since the pain did not go away, tooth 26 was then endodontically treated several times, but the pain is unchanged. What do you do? 11 Per Alstergren: The temporomandibular joint. Oral Neuroscience Course 2010 2014-03-04 touch Pin-prick Definition Atypical Odontalgia Pressure pain • Pain located in a region where a tooth has been endodontically or surgically treated temperature • Chronic pain (> 6 months) • No pathological cause detectable in clinical or radiological examination. • Synonyms: phantom tooth pain, idiopathic toothache, CCDAP Malmö University | Thomas List och Arne Petersson 2014-03-04 Malmö University | Thomas List och Arne Petersson 2014-03-04 CBCT 31 Atypisk Odontalgi A comparative analysis of MRI and radiographic examinations of patients with atypical odontalgia. Pigg, List, Abul-Kasim, Maly, Petersson. J Orofacial Pain 2014. MRT T1 fs gd MRT T2 stir n (%) + – Total + 6 (30) 2 (10) 8 (40) – 3 (15) 9 (45) 12 (60) Total 9 (45) 11 (55) 20 (100) 32 CBCT 20 patienter diagnosticerade med atypisk odontalgi. Patienterna är undersökta med intraorala röntgenbilder, panoramaröntgen, CBCT och MRT med T1, T2 STIR, (3D CISS), T1 gd, T1 fs gd Radiographic bone defect Pigg et al2014-03-04 2010 Malmö University | Thomas List och Arne Petersson MRT T1 MRT T2 stir MRI changes in signal n (%) MALMÖ HÖGSKOLA 12 Per Alstergren: The temporomandibular joint. Oral Neuroscience Course 2010 CBCT MRT T2 stir MRT T1 fs gd Atypisk Odontalgi 2014-03-04 DC/TMD i Grundutbildningen och Specialistutbildningen • MRT visade inga signalförändringar i smärtregionen hos majoriteten av patienterna (60%) • Fynden vid MRT och CBCT var signifikant korrelerade och gav samma resultat hos 75% av patienterna När röntgenfynden är osäkra, speciellt i regioner där ett flertal behandlingar har genomförts, kan MRT styrka argumentet att undvika vidare tandbehandling. Fler studier behövs för att utreda nyttan av MRT. MALMÖ HÖGSKOLA Malmö University | Thomas List och Arne Petersson 2014-03-04 RDC/Orofacial Pain Axis I : Diagnosis Axis II: Psychosocial assessment Axis III: Biomarkers 13