THE IMPACT OF THE POSTOPERATIVE ‘FAST-TRACK’ PROTOCOL ON PATIENT MANAGEMENT AND OUTCOMES A Sharkey, P Braidley, N Briffa, G Cooper, S Forlani, D Hopkinson, T Locke, P Sarkar, G Wilkinson, G Chetty Northern General Hospital, Sheffield Introduction A stay on the intensive care unit (ICU) is a significant component of the cost of cardiac surgery Move towards ‘fast-tracking’ patients Early extubation and management on a high dependency unit Predictors of failure1 Impaired left ventricular function with or without recent acute coronary syndrome ‘Re-do’ operation Extracardiac arteriopathy Preoperative intra-aortic balloon pump Raised serum creatinine Nonelective and complex surgery Aims We sought to determine if there was any difference in postoperative management and complication rates between patients who were fasttracked and those who were not Methods Two groups: CABG x3 + AVR 6 month period PCU and CICU admissions books reviewed 10 consecutive fast-tracked patients for each group Fast-track criteria examined Info-flex database used to determine 10 consecutive cases sent to CICU that were ‘fast-trackable’ Fast Track Criteria Age 75yrs or less Moderate to good LV function Creatinine <125 Diabetes only if well controlled Into recovery before 1430 No unresolved intra-operative event Apparent adequate haemostasis Definite exclusions Not meeting above criteria Mitral valve replacement ‘Redo’ valve operations Previous history of CVA Swan-Ganz catheter Infoflex and case note review Patient demographics Euroscore Bypass and cross clamp times Time to extubation Volume of fluids given in 1st 12 hours Blood products given Inotrope useage Date of removal of lines Date of removal of urinary catheter Number of days before return to the ward Post-operative complications Results Age: Group Destination Mean (yrs) SD CABG CICU 62.4 6.004 PCU 65.5 6.899 0.228 CICU 62.8 12.19 PCU 63.5 11.84 0.897 AVR p Logistic EUROscore: Group Destination Mean SD CABG CICU 2.17 1.572 PCU 2.41 1.212 CICU 4.01 3.163 PCU 4.22 2.798 AVR p 0.699 0.874 AVR Time to extubation PCU CABG CICU PCU CICU 0 2 4 Mean time to extubation (hrs) 6 Group Destination Mean (hrs) SD AVR PCU 2.261 1.320 CICU 5.841 2.114 PCU 3.093 2.067 CICU 5.657 4.170 CABG p 0.00003 0.02 Volume of fluid in 1st 12 hrs AVR PCU CABG CICU PCU CICU 0 1 2 3 4 5 Volume of fluids in 1st 12 hours (L) Group Destination Mean (L) SD AVR PCU 2.764 0.527 CICU 3.336 0.584 PCU 2.951 0.932 CICU 4.002 0.660 CABG p 0.018 0.006 Units of red cells given postoperatively AVR PCU CICU CABG PCU CICU 0 0.2 0.4 0.6 0.8 Red cells given (units) 1 1.2 Group Destination Mean (units) SD AVR PCU 0.2 0.632 CICU 0.7 1.159 PCU 0.4 0.516 CICU 1.2 1.475 CABG p 0.15 0.07 Noradrenaline useage AVR PCU CABG CICU PCU CICU 0% 10% 20% 30% 40% 50% 60% 70% Noradrenaline Group Destination Noradrenaline AVR PCU 10% CICU 10% PCU 20% CICU 70% CABG Time until central line removed AVR PCU CICU CABG PCU CICU 0 1 2 Time (days) 3 4 Group Destination Mean (days) SD AVR PCU 2.5 0.707 CICU 2.1 0.568 PCU 2.1 0.568 CICU 3.5 1.510 CABG P 0.18 0.013 Time until arterial line removed AVR PCU CICU CABG PCU CICU 0 0.5 1 1.5 Time (days) 2 2.5 3 Group Destination Mean (days) SD AVR PCU 1.9 0.876 CICU 1.3 0.483 PCU 1.4 0.516 CICU 2.9 1.595 CABG p 0.07 0.011 Time spent in a critical care environment AVR PCU CICU CABG PCU CICU 0 1 2 Time (days) 3 4 Group Destination Mean (days) SD AVR PCU 2.2 1.135 CICU 1.8 0.789 PCU 1.6 0.699 CICU 3.7 0.699 CABG P 0.372 0.004 Respiratory complications 30 20 10 0 CICU PCU CABG CICU PCU AVR % respiratory complications Group Destination % respiratory complications CABG CICU 30 PCU 0 CICU 10 PCU 0 AVR Discussion No significant difference in the pre-operative condition or the co-morbidities of the patients Most of the differences found were in the CABG group In both groups, those sent to CICU had a longer time to extubation Early extubation reduces length of stay in both high dependancy units and overall hospital stay2 Early extubation has a lower re-intubation rate2 Much larger volume of IV fluids given in the 1st 12 hours in the CICU groups A significantly higher number of units of red cells given to the CABG patients in CICU Red blood cell transfusions associated with a greater risk of infection, ischemic postoperative morbidity, hospital stay and increased early and late mortality3-5 Inotrope usage is also associated with increased hospital stay and mortality6 Prolonged length of time CVP lines are left in situ increases the risk of sepsis Associated with multi-organ disfunction, prolonged ITU stay and in hospital mortality7,8 Less time spent in a critical care environment by those fast tracked No respiratory complications in those fast tracked ?due to early extubation Early ambulation associated with early extubation and transfer to ward environment – less DVT/PE Conclusion A fast track approach has been found to be feasible and beneficial in numerous studies, including ours All patients who are ‘fast-trackable’ should be fast-tracked whenever feasible Time pressures in recovery should not preclude patients from being fast-tracked If fast-tracking is not possible, fast-track protocols should be employed on CICU Changes since this study Fast-track criteria modified Older patients Higher creatinine Poor LV function A fast-track approach has been proven to be appropriate in patients over 709 Limitations Small study population Limited fast track criteria References • • • • Constantinides VA, Tekkis PP, Fazil A, Kaur K, Leonard R, Platt M, Casula R, Stanbridge R, Darzi A, Athanasiou T. Fast-track failure after cardiac surgery: development of a prediction model. Crit Care Med. 2006 Dec;34(12):2875-82 Dmitri Chamchad MD, ‡, Jay C. Horrow MD, MS‡, , , Lev Nachamchik MSc, Francis P. Sutter DO†, Louis E. Samuels MD†, ‡, Candace L. Trace RN, BA†, Francis Ferdinand MD† and Scott M. Goldman MD. The Impact of Immediate Extubation in the Operating Room After Cardiac Surgery on Intensive Care and Hospital Lengths of Stay. J Cardiothorac Vasc Anesth. 2010 Jul 21 Murphy PJ, Connery C, Hicks GL, Jr, Blumberg N. Homologous blood transfusion as a risk factor for postoperative infection after coronary artery bypass graft operations. J Thorac Cardiovasc Surg. 1992 Oct;104(4):1092–1099 Collins JD, Bassendine MF, Codd AA, Collins A, Ferner RE, James OF. Prospective study of post-transfusion hepatitis after cardiac surgery in a British centre. Br Med J (Clin Res Ed). 1983 Nov 12;287(6403):1422–1424 Gavin J. Murphy, BSc, ChB, MD, FRCS(CTh); Barnaby C. Reeves, BA, MSc, DPhil; Chris A. Rogers, BSc, PhD; Syed I.A. Rizvi, MBBCh, MRCS; Lucy Culliford, BSc, MSc, PhD; Gianni D. Angelini, MCh, MD, FRCS, FETCS. Increased Mortality, Postoperative Morbidity, and Cost After Red Blood Cell Transfusion in Patients Having Cardiac Surgery.Circulation. 2007;116:2544-2552. References (cont) 6. 7. 8. 9. Rady, Mohamed Y. MD, PhD, FRCS, MRCP; Ryan, Thomas MB, MRCPI, FFARCSI; Starr, Norman J. MD Perioperative determinants of morbidity and mortality in elderly patients undergoing cardiac surgery Critical Care Medicine:September 2001;29:S163-S172 Serkan Öncü,1 Halit Özsüt,2 Ayşe Yildirim,3 Pinar Ay,4 Nahit Çakar,3 Haluk Eraksoy,2 and Semra Çalangu2. Central venous catheter related infections: Risk factors and the effect of glycopeptide antibiotics. Ann Clin Microbiol Antimicrob. 2003; 2: 3 Marin H. Kollef, Linda Sharpless, Jon Vlasnik, Christina Pasque, Denise Murphy, and Victoria J. Fraser The Impact of Nosocomial Infections on Patient Outcomes Following Cardiac Surgery CHEST September 1997 vol. 112 no. 3 666-675 Kogan A, Ghosh P, Preisman S, Tager S, Sternik L, Lavee J, Kasiff I, Raanani E. Risk factors for failed "fast-tracking" after cardiac surgery in patients older than 70 years J Cardiothorac Vasc Anesth. 2008 Aug;22(4):530-5