© Copyright P.K.B. Tewarie, 2014 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronically, mechanically, by photocopying, recording, or otherwise, without the prior written permission of the author. Lay-out by: Printed by: Nikki Vermeulen, Ridderprint BV, Ridderkerk, the Netherlands Ridderprint BV, Ridderkerk, the Netherlands ISBN: 978-90-5335-963-1 VRIJE UNIVERSITEIT Functional brain networks in multiple sclerosis: linking structural pathology to clinical disability ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad Doctor aan de Vrije Universiteit Amsterdam, op gezag van de rector magnificus prof.dr. F.A. van der Duyn Schouten, in het openbaar te verdedigen ten overstaan van de promotiecommissie van de Faculteit der Geneeskunde op vrijdag 19 december 2014 om 9.45 uur in de aula van de universiteit, De Boelelaan 1105 door Prejaas Kavish Baldewpersad Tewarie geboren te Amsterdam Promotiecommissie promotoren: prof.dr. C.J. Stam prof.dr. C.H. Polman copromotoren: dr.ir. A. Hillebrand prof.dr. F. Barkhof “Architect, finally I have met you. You will not rebuild your house again... Oh lord of my own ego, you are pure illusion, you do not exist. The earth is my witness” Gautama Buddha, Dhammapada 11:154 Voor mijn ouders & grootouders