A Short History of Medicine 2000 B.C. 1000 A.D. 1850 A.D. 1940 A.D. 1985 A.D. 2000 A.D. Here, eat this root That root is heathen. Here, say this prayer. That prayer is superstition. Here, drink this potion. That potion is snake oil. Here, swallow this pill. That pill is ineffective. Here, take this antibiotic. That antibiotic is artificial. Here, eat this root. TCM Kidney Disease Kidney Physiology Kidney Jing Pediatrics Ear Diseases Water Sound winter ears Body Part north Opening cold Season Direction fear Climate groaning Emotion bones Zang/Fu KID/BL FEAR According to Plain Questions (Su Wen), fear leads to Qi leakage. Fear allows the Qi to flow downwards and leak. When this happens, the Kidney Qi is not firm, thus resulting in incontinence, hind limb weakness, and abortion. The Chinese word kong refers to Fear which is associated with the Kidney. An animal that experiences Fear will become scared and run away. FEAR Qi goes downward & leaks Kidney Qi not firm Urinary incontinence Hind limb weakness Premature ejaculation Abortion WATER TYPE Personal Characteristics: Introverted Terrified or fearful about everything Quiet, but a good observer Skilled at planning and scheming Good advisor or supervisor Prefers deep thought Willing to live alone Very consistent, but slow when doing something Sinister or insidious if evil Fear biter Physical Characteristics: Thin, middle sized body Black hair on the head Deep, big eyes and big ears Cold intolerance: Prefers to stay in a warm area Pulse: Deep Not a favorable type for a stallion Disease Predispositions: Edema Infertility Back pain Urinary infections Diarrhea at dawn Depression Life Span: Very long Kidney The Kidney is the Minister of the Water pathway. The Kidney is the root of prenatal life. With age, the Kidney essence gradually diminishes. Kidney essence should be always conserved. If there is a disorder, the Kidney is almost always deficient. Storing Jing (Essences) Governing Water Metabolism Acts as the gate of water Controlling the Reception of Qi Congenital Jing Acquired Jing Holds or pulls Qi down from Lung It is in charge of inhalation Dominating Bone, Producing Marrow, and Filling up the Brain Influences bones and the central nervous system TCM 24 Hour Clock LIV GB TH 1-3 AM LU 3-5 AM LI 5-7 11-1AM 9-11 PM PC 7-9 PM KID BL ST 7-9 AM SP 9-11 AM HT 5-7 PM 3-5 PM SI AM 1-3 PM 11-1 PM Water Balance Sheng cycle nourishes it Ke cycle restrains it Provides the tension Patterns of Kidney Disharmony Lower back pain Frequent urination (bedwetting) Ringing in the ear Lack of hearing acuity/deafness Excessive fear Lack of willpower Kidney Physiology Genetics ruled through kidneys (base intelligence) Houses & governs the essence, rules the senses (jing) Jing of heart rules tongue, speech, consciousness, intelligence Jing of spleen rules taste, development of flesh Jing of lung rules smell, acceptance Jing of kidneys rules hearing (listening), willpower (discipline) Jing of liver rules vision, creativity, decision making Rules growth & development Genetic Control of Life Obtain one pair of DNA from each parent Some areas are imprinted Suppressed so that only one gene is active No back up if something damages remaining gene Suspect 200 regions Responsible for many later life diseases Kidney Physiology Storing Jing (Essences) Congenital Jing: • • • • • • Inherited from the parents Congenital foundation of life (Genetic materials: DNA, genes) Nourishes the fetus before birth Regulates development, growth, aging, and reproduction after birth Deficiency of Kidney Jing Infertility and retarded growth Controls the 7-year (female) and 8-year (male) cycles of development and growth Acquired Jing: • Also called Essence of Zang-Fu • Basic substance for maintenance of the vital activities • Extracted from Food Qi by Spleen Kidney Essence Impowers Kidney provides initial spark to all other organs During prenatal life of fetus Timing & genetics dictate the resulting disease Which organ is affected Spleen for Postnatal Essence While kidney is central for prenatal life, Spleen is central for postnatal life Maintains vitality of other organs Helps protect and replentish prenatal essence The Jing Candle Candle bruning at both ends Original Kidney Jing Acquire Spleen Jing Candles are different sizes based upon Kidney Jing Replenished slowly by spleen JING Gu Qi Telomeres Highly repetitive region ofDNA at the end of a chromosome DNA polymerase complex is incapable of replicating all the way to the end Every time a cell with linear chromosomes divides Pretects from loss of vital genetic information, which is needed for cell's activities Lose a small piece of one of its strands of DNA. This process has been referred to by James Watson and Alexei Olovnikov as the "end replication problem" (1971) Have a function in the ageing process. What does this mean? Clones are inherently deficient Adult stem cells are less robust Artificial increase in telemeres leads to cancer When the telemeres are gone, life ends Life is Balance Hope you get the best Jing Protect it with diet Live well and enjoy what you are given Make lemonade Yuan Qi (Primary Qi, Source Qi, Original Qi) Derived from the Kidney Essence or congenital Essence It is Essence in the form of Qi, rather than fluid. Requires supplementation and nourishment by the Food Essence (Gu Qi) Comprises the Primary Yin (Kidney Yin) and the Primary Yang (Kidney Yang) It is the original dynamic motive force of normal activities. Distributed to the whole body by the Sanjiao Impels the Zang-Fu organs to bring normal activities into play Maintains normal growth and development of the body Pathology: Yuan Qi Deficiency results in decreased disease resistance Energy of Life Yuan Qi impels the function of the organs JING PATHOLOGY Signs of Jing Deficiency Retarded or poor growth Developmental orthopedic diseases Loss of vitality Infertility Early aging Jing Pathology Can be acquired from too much strain on the candle One of the problems of the Chinese emperors Pathology of Kidney Jing Deficiency (original or acquired) Child Fear or Stress or Pathogens Kidney LU/LI- -asthma & edema Parent KID- -nephritis LIV- -joint disease Grandchild HT/PC- -shen Organ Grandparent Channel SP/ST- -damp Bone, Marrow, Head Ears BL Incontinence CAM Use in Kids 1992-2005, 66 pediatric utilization studies US, Canada, UK, Australia, Turkey, Norway… General and subspecialty populations Use increasing Complementary and Alternative Research and Education Program Pediatric Epidemiology Spiegelblatt ’94 Pediatrics ; 11% used prof. CAM Ottolini, et al, W, DC, ‘98: 20% of kids in 4 practices Taylor, et al, Seattle, ‘98: 30% -50% use echinacea or vitamin C for kids’ colds Indiana teens ‘98: 20-30% of athletes take supplements Crow, et al. Ped Res, ’03: 46% w/vitamins; 15% wo/vitamins in Chicago PPRG Wilson, et al AmbPeds ’02: 53% of Rochester teens Lin, et al J Clin Anesth ’04: 30% pediatric pre-op pts use herbs Breuner APAM ‘98: 70% homeless teens Children with other conditions Autism: 30%; Asthma: 72%-81% of minority (H and Af.A.) families; Cancer: 47% of kids at WFUSM in 2003; 73% of kids in Washington state in 2001; CF: 65%, mostly prayer Cerebral palsy: 56% of 235 families in Ann Arbor ED: 53% used herbs, Atlanta IBD: 41% of kids in Boston, Detroit, London Rheumatology: 64% of 141 in Toronto, 2003 Special needs: 24% for kids with correctable condition vs. 76% for kids with non-correctable condition Which CAM therapies most commonly used? Prayer – most common, least worrisome to MDs Herbal therapies, vitamins, minerals and other dietary supplements – most worrisome to MDs Chiropractic – most common professionally provided to adults; historical competitive threat Massage – most common professionally provided to kids; often taught to parents or provided informally Homeopathy – not well enumerated; confusion with herbs Yoga, Tai Chi Acupuncture/acupressure Biofeedback, hypnosis What are pediatricians most often asked about CAM? Herbs, dietary supplements (67%) Chiropractic (59%) Nutrition and special diets, vegetarian, macrobiotic diets (46%) Homeopathy (36%) Therapeutic exercise, yoga (34%) Hypnosis, biofeedback or meditation (23%) Massage or other bodywork (17%) …. Prayer (13%) Kemper, O’Connor. Amb Peds, 2004 Only 40% tell docs about CAM “Natural”, not medical; irrelevant , “not important for the doctor to know” 61% Docs not interested; “the doctor never asked” 60% “None of the doctor’s business” 31% “Doctor would not understand” 20% Cultural practice - embarrassing or private, <20% Fear of physician reaction (disapproval, abandonment, worse medical care) < 15% Eisenberg DM, et al. Arch Intern Med, 2001; 135: 344-51 Pediatric AP ABDOMINAL PAIN ANOREXIA CHILDHOOD DIARRHEA COUGH OTITIS ICTERUS NEONATORUM CONVULSIONS PARALYSIS Pediatric Colic Patterns Cold in the middlejiao Retention of food Blood stagnation Yang deficiency Consequences of Jing Deficiency Leads to disease of organs Severe disease Heart GI tact Lung Kidney Liver Early affects Mild disease Later effect Chance 8 month M Lhasa apso Seizures for 1 month Tongue: red purple Pulse: deep & weak Di Tan Tang and Epimedium Powder Kidney Jing Deficiency Kidney Jing Deficiency Blood Deficiency Kidney Yin Deficiency Liver Yin Deficiency Fails to Nourish Jin (sinews) Internal Wind Seizures Kidney Jing Deficiency Hz: Seizures < 1 year of age Dry nose & mouth Tongue Pale or red AP TCM Herbal Pulse Weak & thready Rx Principle • extinguish the wind and astringe or nourish the kidney jing KID-3, BL-23, SP-6, GV20, ST-36, HT-7, GB-20, An Shen, Da Feng Men Di Tan Tang and Epimedium Powder Epimedium Powder Epimedium Cuscuta Cistache Paeonia Polygonum Actinolite Cynomorium Psoralea Dipsacus Lycium Condonopsis Astragalus Rehmannia Angelica Ophiopogon Scrophularia Citrus Yin Yang Huo Tu Si Zi Rou Cong Rong Bai Shao Yao He Shou Wu Yang Qi Shi Suo Yang Bu Gu Zhi Xu Duan Gou Qi Zi Dang Shen Huang Qi Shu Di Huang Dang Gui Mai Men Dong Xuan Shen Chen Pi Tonify Kid Yang/Jing, Promote Sexual Desire Tonify Kid Yang, Jing & Yin Tonify Kid Yang & Yin Nourish Liver Yin & Blood Nourish Blood & Jing, Benefit Hair Tonify Kid Yang Tonify Kid Yang Tonify Kid Yang & Strengthen Bones Tonify Kid Yang & Promote Fracture Healing Nourish Liver Yin, Benefit Eyes Tonify Qi Tonify Qi Nourish Kid Yin & Jing Nourish Blood Moisten & Nourish Yin Cool Blood & Clear Heat Move Qi & Relieve Pain Jocko Jocko Problem List Shen Disturbance Hydrocephalus Diagnosis Jing Deficiency Yin deficient • Confirmed ultrasound Hepatoencephalopathy • Confirmed BW Overall poor development Treatment TCVM Tongue • thin-red Pulses • Deep, weak fast particularly on right side Hydrocephalus formula Liu Wei Di Huang Epimedium powder Ear Disease One of most common complaints for dogs & cats Poor design Lack of essence Decreased immunity Failure to support child • Passes heat to ears God’s Boo Boo Poor design No drainage Covered with flap No air circulation Deep, Dark Hole Infections in Children Some feel that the cause is the use of antibiotics Find that CAVM methods have a more effective longterm outcome Chiropractics Craniosacral techniques TCM How Ears Help in TCM Exam Otitis Externa Itchy Red Painful Damp- -Heat with Wind External pathogen Liver yin deficiency Patterns Channels Near the Ear SI, TH, GB, BL, GV AP for Ear Disease Local points on SI, TH, GB, BL, GV medians Influential points Points for excess or deficiency Excess Patterns Damp Heat for Otitis Red tongue Fast, superficial pulse Otitis Patterns Pathology of Liver Heat Liver Blood & Yin Deficiency Child Heat & Damp KID/BL LIV Shen Disturbance Liver Heat Parent Grandchild Organ Grandparent LU/LI Channel Feet Eyes GB Ears SP/ST Ear exam Don’t forget to look! May find a cause Foxtail Polyp Tumor Parasite Can culture TCM Herbals Clear Damp-Heat Treat Topically Long Dan Xie Gan Ear Damp-Heat TCM Ear Drops Western Ear Formula Improve immunity Canine Antioxidant Formula Canine Cancer Formula Garlic (fresh) orally Westlab Pharmacy 1-800-4WESTLA Long Dan Xie Gan Tang Gentiana Gardenia Scutellaria Plantago Alisma Akebia Angelica Rehmannia Bupleurum Licorice Long Dan Cao Zhi Zi Huang Qin Che Qian Zi Ze Xie Mu Tong Dang Gui Sheng Di Huang Chai Hu Gan Cao Clear Liver Heat, Clear Damp-Heat Clear Damp Heat Clear Damp-heat Drain Damp-heat Drain Damp Drain Damp-Heat Nourish Blood Nourish Yin, clear Heat Soothe Liver Qi transporter Harmonize Ear Damp-Heat Artemisia Bupleurum Scutellaria Moutan Prunulla Lophatherum Tribulus Luffa Stagnation Melia Qing Hao Chai Hu Huang Qin Mu Dan Pi Xia Ku Cao Dan Zhu Ye Bai Ji Li Si Gua Teng Clear Damp-Heat Soothe Liver Qi Clear Damp-Heat Cool Blood Clear Heat Clear Heat Clear Heat Transform Phlegm, Resolve Chuan Lian Zi Move Qi TCM Ear Drops Coptis Huang Lian Clear Heat, Detoxify Alum Bai Fan Borneol Bing Pian Dry Damp, Transform Phlegm, Stop Bleeding, Relieve Itching Clear Heat, Relieve Pain, Open Orifices, Dissipate Swelling Glycerol Gan You Carrier Western Ear Drops Detergent Solution: 1 drop of “free” dishwasher soap 8 ounces of water Vinegar Solution: 1 ounce apple cider vinegar 3 ounces of water Vitamin E/garlic oil: crush one clove of garlic (use press) into 1 ounce of extra virgin olive oil let sit overnight at room temperature pour oil into dropper container add content of a 1000 IU vitamin E capsule use 2-3 drops in the ear canals, plus 1-2 on the pinnae Sheena 7 yr, FS GSHP History of chronic otitis externa Rx Atbs/Tramadol Neuroexam Mild CP LRL Mild Babinski LRL Eye Drop LS Sheena Sheena Pseudomembranous coating of left ear canal and mouth Dx Candida Infection Invasion of DampHeat secondary to Wei Qi deficiency Sheena Treatments Western • • • • Fluconazole Ear Solutions Aleo Vera gel Diet change Purina JM Treatments TCVM • AP Shan Gen, LI-4, GV14, ST-4, ST-36, TH5, and ST-44 • Herbal Long Dan Xie Gan Ku Shen Si Wu Tang Wei Qi Booster Inner Ear Disease 8th Nerve Signs 7th Nerve Signs ear & lip droop lack of palpebral reflex nose turn nostril flaring Horner’s Syndrome Horner’s Syndrome Small Animals Ptosis Myosis Enophthalmos Large Animals Facial sweating (horse) Lack of muzzle sweating (cow) Inner Ear Disease Most cases are secondary to bacterial infection (otitis media & interna) extension from otitis externa pharyngitis with extension up the Eustachian tube hematogenous spread Dx of Inner Ear Disease PE, NE, OE Schirmer’s tear test CBC UA Skull Radiographs Other (if indicated) Chest & Abdominal Radiographs Ear Culture Cardiac Exam Normal bulla radiograph Note: sharp bone edges with symmetrical appearance. Inner Ear Infection L R R Right-lateral and DV radiograph of dog with unilateral otitis interna showing sclerosis of the tympanic bulla on the right side with loss of detail in the region of the osseous petrous-temporal bone. Inner Ear Infection Treat with bacteriocidal drugs which penetrate bone and blood-tissue barriers Combination therapy • cephalosporins • sulfa drugs Enrofloxacin Must treat 6-8 weeks Inner Ear Disease Treat with antibiotics Recheck at 6 months and recheck in 2 re-examine any abnormalities (such as weeks Recheck in 1 month abnormal bulla radiographs) if better, continue if worse, reassess if normal, stop antibiotics if still residual problems, continue 2 more weeks If problems worsens or persists without change for 4 weeks, consider referral. Inner Ear Disease Other Neoplasia neurofibromas osteosarcomas FeLV Prognosis is Poor Other Infections Fungal Prognosis Guarded to Poor Inner Ear Disease Consider Advanced Imaging Techniques If owner can not afford additional tests or referral, may try changing antibiotics. Main reason for failure is not treating long enough. Bone Scan MRI Scan Consider Surgical Drainage of Bulla Myringotomoy Chance to look at the middle ear and get culture Personally, I do not think it is that necessary Most ear problems (like sinusitis) are from failure of immunity not infection Inner Ear Infection Inner Ear Neoplasia B.A.E.R. test Provides indication of the ability of the auditory portion of the 8th nerve to function and relay that information through the brainstem toward the cerebral cortex. Ear Polyps in Cats Benign growth in the external ear canal which causes signs by extension. Can also be pharyngeal mass which grows into middle ear via the eusthasian tube. Ear Polyps in Cats Treatment is surgical removal. Damage can be permanent, if pressure necrosis has destroyed the inner ear structure. Bilateral I.E. Disease No Head Tilt No Nystagmus spontaneous or physiologic Wide head excursions due to inability to fix eyes on vertical with movement. Open mouth radiograph with chronic changes in both bullas Bilateral I.E. Disease MRI image shows bilateral disease in middle and inner ear. May respond to aggressive antibiotic therapy. Some patients will also be deaf. Bilateral Vestibular Lacks classical signs Wide head excursions No physiologic nystagmus Inner Ear Disease -- TCM Invasion of external pathogen leading to wind, heat, damp or GB heat from liver yin deficiency Heat boils the fluids leading to the accumulation of phlegm. Quiet the wind, reduce heat, disperse damp and activate the blood to dissolve stagnation. Inner Ear Disease -- TCM Points Constitutional points Clear wind & heat • GB20, LI4, LI11, GV14 Calm the shen • PC6, HT7, GV17, GV20, GV21 Eliminate damp • SP9 Activate Qi & blood • ST36, ST40, Xin shu (BL17) Local points • TH17, TH18, TH21, SI19, GB2, Er jian, An shen Hope Even without Jing, life can be full Dogs live in the now One message they teach us is that it does not matter how long we live, only that we live well