FDA-MANDATED ALTERNATIVE TO
BISPHENOL-A
Kristina Lenn
Kevin Miles
Gregory Jackett
Isaac Norton
August 5, 2010
Foreshadow
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Introduction
Effects of BPA on Human Physiology
Possible Alternative Plastics to BPA
Manufacturing Analysis
Conclusion/Recommendation
Questions
Introduction
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Nalgene water bottles
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BPA usage
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FDA regulations
Meet the Team
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Kristina Lenn
Project Manager
 Bachelor of Science in chemical engineering with an
emphasis in biological engineering
 Research on molecular modeling and computer simulation
 Worked with Nalgene for one year
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Meet the Team
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Kevin Miles
 Team
Leader during the Project Proposal
 Bachelor of Science in chemical engineering with an
emphasis in biological engineering
 Research on tissue engineering
 Worked with Nalgene for one year
Meet the Team

Gregory Jackett
 Team
Leader during the Final Presentation
 Bachelor of Science degree in chemical engineering
with emphasis in molecular engineering and
nanotechnology
 Research on fatigue-induced muscle injury
 Worked with Nalgene for one year
Meet the Team

Isaac Norton
 Team
Leader during the Final Report
 Bachelor of Science in chemical engineering with an
emphasis in product and process design
 Work experience in quality control
 Worked with Nalgene for one year
Background
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BPA=Bisphenol-A
Polycarbonate
Chemical in water bottles and pop cans
Problem
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Recognized by the human body as estrogen
Absorbed by breast tumor cells
Promote breast and prostate tumor growths
Task
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BPA effects
Harmless Alternatives
Manufacturing Techniques
BPA EFFECTS ON HUMAN PHYSIOLOGY
Kevin Miles
A Look Ahead…
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Previous Statements
Enviornmental exposure to BPA
BPA Leeching
The Endocrine system
BPA linked to cancer
Conclusion
~ 25 ng/kg/day
Human Exposure:
52-74ng/kg/day
50,000 ng/kg/day
How does the endocrine
system work?
 BPA increased the level of
hormone
receptors produced by
a prostate gland cell
 Some dosages of BPA were
environmentally relevant
 An increase in cell receptors fuels growth of the cell
 Cells can proliferate out of control, resulting in
cancerous tumor cells.
Conclusions
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BPA is harmful in lower doses
BPA can leech into food/beverages at relevant
levels
BPA exposure increases risk of cancer
ALTERNATIVE POLYMERS
Gregory Jackett
The Line up
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The Candidates
Strength
Toughness
Liquid Stability
UV Stability
Thermal Stability
The Ranking
PETE(Polyethylene terephthalate)
Atactic Polystyrene(PS)
Eastman Tritan Copolyester
Strength
Toughness
Liquid Stability
UV Stability
Copolyester?
Thermal Stability
The Ranking
Copolyester
PETE
Polystyrene
MANUFACTURING ANALYSIS
Isaac Norton
Forecast
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Polymerization Method
Safety
Quality
Retooling
Ranking
Method
Safety
Reaction
Heat
Runaway
Quality
The Ranking
PETE
Copolyester
Polystyrene
Conclusions
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Hazardous in small concentrations
Carcinogenic developmental changes
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Copolyester’s better material properties
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PETE’s better safety and quality properties
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Our Solution Is…
PETE
Just a Reminder…
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The Problem
BPA Effects
Possible Alternatives
Manufacturing Comparison
The Solution
References
http://www.intuitive-recruitment.co.uk/
http://fondnessforreading.blogspot.com/2008/12/melting.html
http://jalopnik.com/276775/wrecking-ball-on-the-loose
http://www.better-leadership.com/great-offices.html
http://www.greenerist.com/2009/02/green-tip-get-a-bpa-free-water-bottle/
http://health.allrefer.com/health/cancer-ovarian-cancer-metastasis.html
http://www.tuxedoranch.com/images/featured/bpa-free-1.png
http://www.sitnews.us/MacDougall/111207_PETE.jpg
http://www.extension.iastate.edu/newsrel/reiman/PolystyrenePot.jpg
http://www.innovationlab.eastman.com/NR/rdonlyres/4C99D9B3-B19A-4FD5-A60F8115B0DF5064/0/example_lrg_camelbak1.jpg
http://www.eastman.com/Brands/Eastman_Tritan/PublishingImages/TritanWater.jpg
References
http://i1.treklens.com/photos/5947/dscn0425c.jpg
http://grail.cs.washington.edu/projects/office/dewey/china/photos/yunnan/hutiaoxia
/middle/middle14.jpg
http://www.jcu.edu/Philosophy/gensler/nc/images/10.jpg
http://faculty.uscupstate.edu/llever/Polymer%20Resources/Isomerism.htm
http://en.wikipedia.org/wiki/File:Ester-general.svg
Taylor & Francis Group. (2010) Polymers, a property database. Retrieved from
http://poly.chemnetbase.com
QUESTIONS?