Accelerator-based applications and
commercial services
Ari Virtanen
NuPECC mini workshop
13.6.2014
OUTLINE
1. Main commercial applications
Testing of space
electronics
Microfilters
• Customers
• Revenue
2. Other applications
• Materials physics at Pelletron laboratory
• EU, ESA and with other collaborators
3. Future?
4. Conclusions
Radiopharmaceutical
isotopes
Commercial activity
for
space industry
Galactic and extra-galactic heavy
ions and protons
Solar flare protons and
heavy ions
Trapped protons and heavy
ions in Van Allen belts
Heavy ions in magnetosphere
Official test laboratory of ESA since 2005
ESA/ESTEC/Contract No. 18197/04/NL/CP
”Utilisation of the High Energy Heavy Ion
Test Facility for Component Radiation Studies”
Tested satellite electronics in RADEF for ESA,
NASA, JAXA (Japan), CNES (France) and for more
than 40 satellite companies and organizations





International Space Station
Telecommunication satellites
Global Positioning System, GPS
Mission satellites
Earth observation, i.e. EO- satellites
 Global warming
 Weather etc…
ISS
Customers
For example; in 2013
– 46 test campaigns by 28
individual users
– ~25% of K=130 beam time
Other
irradiations
25 %
Research
11 %
Space - ESA
17 %
Space - others
47 %
Commercial activity
for
microfilter industry
Irradiation of polymer films
Beam line
to etching
@
OxypheN
105 pores / cm2
109 pores / cm2
0.1 µm
10 µm
Membrane production
• Current contract until 2018
• Annual income ~260 keur
• Annual beam time usage = 15 x 24hours
X-section of the foil
>100 km irradiated membrane in 4 days
Example: Use in car industry
Modern headlamps are transparent systems with complex thermal
characteristics; moisture, dust and heat affect function and appearance
Porsche Cayenne
Filters, using Oxyphen RoTrac® capillary pore
membrane, remove moisture, vent the headlamp
and stop water and dust (c.f. GoreTex)
Commercial activity
for
medical industry
Radioisotope production
• I-123 project
– Development started 1998, commercial 2002
– Stopped in 2008 partly due to worldwide market and
the construction work for K-30
• F-18 development project
– Started 2007
– Stopped in 2013 due to the delays and bad luck
• Substitutive radioisotope project is currently under
way…
Alpha therapy project
”Targeted medicine is the future, from which the alpha-radioimmunotherapy is an ultimate example”
Curing principle:
Killing principle:
Killing agent, = alpha-emitter, is linked
via a chelator to the targeting antibody
agent, which seeks tumor cells.
Short-range high-energy α-particles
accumulate very effectively their
energy to the tumor cells. Killing
power of alphas is 120 000 times
higher than the long-range low-energy
electrons.
Memorial Sloan Kettering Cancer Center
Crew
Mikko Rossi
Laboratory engineer
Arto Javanainen
Postdoctoral researcher
Jukka Jaatinen
Laboratory engineer
Ari Virtanen
Research director
Heikki Kettunen
Laboratory engineer
Taneli Kalvas
Postdoctoral researcher
Alexandre Bosser
Graduate student
from MU2
Annual revenue
900,000 €
800,000 €
700,000 €
600,000 €
OTHER
MEDICAL
SPACE OTHERS
MEMBRANE
500,000 €
400,000 €
300,000 €
200,000 €
100,000 €
0€
2004
2005
2006
2007
2008
2009
2010
2011
2012
In 2012 – 2013: 7 publications in peer reviewed journals and 2 PhDs
2013
Commercial break
Our concept:
”Business from Top-Research”
won in 2011 the annual
entrepreneurship competition
among 13 Finnish universities
Other applications
Materials physics at Pelletron laboratory
•
Main research fields
– Fundamental ion-matter interactions (cross sections, stopping forces, straggling)
– Materials research applications
•
Facility
– 1.7 MV Pelletron accelerator (in Jyväskylä since 2006)
•
•
Three ion sources, four beam lines
H, He, Cl, Cu, Br, I, and other heavy ion beams, 0.2 – 20 MeV
Thin films processing and applications
Atomic layer deposition (ALD)
ALD tool
Oxides, nitrides, carbides, fluorides, sulphides and
metals with excellent control of film thickness and
high conformality for 3D structures
Lithography with proton beam writing
Large area exposures for high-aspect ratio structures
Microfluidic chips for borrelia infection diagnostics
Functionalized ion tracks
Enhanced electron multiplication in ALD coated
pores
Microfluidic chip
External PIXE
Collaboration with RECENART = Research Center for Art
Other radiation testing activities
• SkyFlash (262890 EU-FP7 Project) http://www.skyflash.eu/
– development of a RadHard by design (RHBD) methodology for non-volatile
flash memories
– 84 keur
• Technical assessment project for ESA
– “Effects of the ion species and energy on the oxide damage and SEGR failure”
– 100 keur addition to the ESA’s basic funding
• Close collaborations with
– Universities (Montpellier2 and Vanderbilt)
– Sandia National Labs
– STMicroelectronics
Future?
New 18 GHz ECRIS (HIISI)
• Higher energies for heavy ions
up to 15 MeV/u
deeper penetration in silicon
irradiations in air with possibility to tilt
• 300 keur from ESA for development
 RADEF competitive with e.g. Texas A&M Univ.
HORIZON 2020
• Proposals for H2020-COMPET-2014 (RADEF as
partner)
1.
2.
3.
4.
5.
SPES (SOI PLL for Earth hostile environment and Space
applications)
SOLIS (SOI Library for Sapce Applications)
SpaceMIST (Space Mixed Signal Circuits and Technologies)
R2RAM (Radiation Hard Resistive Random-Access Memory)
LIRARSUP (Light weight, Radiation Resistant
SUPerconductiong wires for space applications)
• 1-2 projects are expected to pass
• approx. 100 keur per project for RADEF
• Energetic electrons for radiation hardness assurance
(RHA) testing
• 100 keur from ESA
• Ee = 6-18 MeV
• JUICE-mission
(Jupiter Icy Moon Explorer)
– “The most dominant trapped particle constituents at
Jupiter are electrons with energy in the 1 – 100 MeV
range.”
• All ESA’s MEO-satellites (2000 – 35 000 km)
– Navigation (GPS), communication, and geodetic/space
environment science
– Van Allen electron belt (tens of MeV)
NASA/JPL
Electron LINAC (Varian)
Low energy protons for RHA
B. Sierawski, Vanderbilt Univ.
• Stopping of muons vs. protons
• State of the art technologies (< 65 nm)
– errors due to direct ionization of protons
Ground effects due to muons?
• RADEF’s graduate student working on this
Conclusions
• RADEF’s activity is going strong
– firm client base (space industry and Oxyphen)
• approx. 600 keur annually
– strong support from ESA
• 300 keur for HIISI (2015-16)
• 100 keur for high energy electrons (2015-16)
• continuing basic contract 240 keur for 2014-15
– International collaboration (VU, UM2, Sandia, STM)
– partner in EU-FP7 project
– partnering in five H2020 proposals
• Radioisotope production project under way
8.5.2014
CoE SAB meeting
27
Conclusions – the three scenarios?
1,600,000 €
1,400,000 €
1,200,000 €
1,000,000 €
800,000 €
OTHER
Est. MEDICAL
MEDICAL
Est. SPACE
SPACE OTHERS
MEMBRANE
ESA
25% K130=Cautious?
600,000 €
400,000 €
200,000 €
0€
2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017
Commercialisation of K-30 is needed!
Thank you
for your attention