Appraisal, Extraction and Pooling of Qualitative Data and Text - Evidence from qualitative studies, narrative and text. (JBI/CSRTP/2012/0003) Introduction • Recap of Introductory module – – – – Developing a question (PICo) Inclusion Criteria Search Strategy Selecting Studies for Retrieval • This module considers how to appraise, extract and synthesize evidence from qualitative studies and text. Program Overview Day 1 Time 0900 0930 1030 1100 Session Introductions and overview of Introductory Module Session 1: Introduction to Qualitative Evidence Synthesis 1230 1330 Morning Tea Session 2: The Systematic Review of Qualitative Evidence Session 3: Critical Appraisal of Qualitative Evidence Lunch Session 4: Data Extraction 1400 Session 5: Data Analysis and Meta-synthesis 1430 1500 1700 Afternoon tea Session 6: QARI Trial End 11.30 Group Work Group Work 1: Paradigm, methodology and research question Group Work 2: Critical Appraisal using JBI-QARI Program Overview Day 2 Time 0900 0915 Session 1030 1100 Overview of Day 1 Session 7: Systematic review of Textual Opinion Papers Morning Tea Session 8: NOTARI Trial 1200 1230 1330 1645 1700 Session 9: Protocol Preparation Lunch Session 10: Protocol Presentations Session 11: Assessment and Summation End Group Work Group Work 3: Critical Appraisal Session 1: Introduction to Qualitative Evidence Synthesis Qualitative Research is… • “…a situated activity that locates the observer in the world. It considers a set of interpretive, material practices that make the world visible…[it] involves an interpretive, naturalistic approach to the world. This means qualitative researchers study things in their natural settings, attempting to make sense of, or to interpret, phenomena in terms of the meanings people bring to them” (Denzin & Lincoln, 2000) Qualitative research and health care • Health care is a people centered process concerned with health and healing – Health care derives much of it’s knowledge from a range of biomedical sciences • However this does not supply all the knowledge that is necessary to provide holistic care for the patients and clients • Qualitative researchers use humanistic frameworks to examine ordinary activities of everyday life Qualitative Research Findings as Evidence for Practice • Qualitative evidence is of increasing importance in health services policy, planning and delivery. • It can play a significant role in: – understanding how individuals / communities perceive health, manage their own health and make decisions related to health service usage; – increasing our understandings of the culture of communities and of health units; – Informing planners and providers; – evaluating components and activities of health services that cannot be measured in quantitative outcomes. Application of Qualitative Research to Practice • As with quantitative research, results from a single study only should not be used to guide practice • The findings of qualitative research should be synthesized in order to develop recommendations for practice Research Paradigms • Serve as a model/world view or philosophy that structures knowledge and understanding • Define what is to be observed and scrutinised • Prioritise questions • Inform the interpretation of results Dominant Paradigm 1: Positivist/Empirical-Analytical • Assumptions – There is an external, real world of objects apart from people, which is comprehensible to us – Researchers can compare their claims against this objective reality • Seeks to predict and control Dominant Paradigm 2: Interpretive • Assumptions – Reality as we know it is constructed/produced intersubjectively (between people). – Meaning and understanding are developed socially and experientially. – Researchers’ values are inherent in research. – Findings of knowledge claims are created – All interpretations are located in a particular context, setting and moment. • Seeks to understand Dominant Paradigm 3: Critical • Assumptions – Examines issues of power and envisions new opportunities – Main task social critique, whereby the restrictive and alienating conditions of the status quo are brought to light – Common assumptions with Interpretivism; however, moves past describing meaning to emancipation and change. • Seeks to critique and emancipate Qualitative Methodologies Phenomenology • Assumes that people come to know a phenomena through their experience of it • Focuses on INDIVIDUAL meaning • Emphasizes a focus on people's subjective experiences and interpretations of the world. • Understand how the world appears to others. Ethnography • Study of Culture/specific cultural group. – What is the way of life of this group of people? – Everyday life is worth of study. • Focuses on SOCIAL meaning. • Researcher immerses self in cultural group. – Field Work - primarily participant observation and interview data • Focuses on the context of communities • Used increasingly in healthcare to explore the relationship between health and culture. Grounded theory • Develop theory grounded in real world; • Searches and generates theoretical explanations from observations of the world (induction); • The constant collection and iterative analysis of data to enable theory to emerge; and • Data are not constrained by predetermined theoretical framework, but define boundaries of inquiry. Action Research • Basis in critical social science; • Researchers interact with the participants to achieve change; • Often community-based; – used with implementation studies in healthcare; and • Treats the individual as an autonomous being, capable of exercising agency Discourse analysis • Discourse – to talk, converse; hold forth in speech or writing on a subject; • Discourse as patterns of ways of representing phenomena in language; • Application of critical thought to social situations and the unveiling of (hidden) politics within socially dominant or marginalised discourses. Qualitative data analysis • Is based on principles of thematic analysis for most methodologies – A process of identifying and presenting meaning in the form of themes, metaphors or concepts; • there is wide variability in the terms used and how they are defined; – Not suited to all methodologies (i.e. discourse analysis) Qualitative data analysis • Three strategies: – Data analysis as a separate step following data collection – Data analysis occurs simultaneously with data collection – Data collection and analysis are ‘staged’ Congruity between Paradigm, Methodology and Methods Paradigm POSITIVIST Methodology Methods Clinical Trials Measurement of outcomes Cohort Studies Other Methodologies using numerical data INTERPRETIVE CRITICAL Phenomenology Interviews Ethnography Observation Grounded Theory Field Work Action Research Group Processes Reflective Journaling Paradigm Methodologies Methods Randomized Controlled Trial Measurement of variables Empirico-Analytical Cohort Study Correlational Study Time Series Study Case Series Study Positivist/ Interpretivist Phenomenology Ethnography Grounded Theory Critical Action research Discourse Analysis Interviews Focus groups Observations Field work Field observations Purposeful interviews Textual analysis Participative group work Reflective Journals In-depth interviews Focus Groups Analysis of communications, written text and policies Group Work 1 • In pairs, work through the Group Work 1 task in the Workbook. • Reporting back Session 2: The Systematic Review of Qualitative Evidence Trends and Debates within the International Literature Meta-synthesis: approaches Approach Purpose Evidence of Interest Search Strategy Critical Appraisal Data Extraction Method of Synthesis Outcome Software Available Narrative Synthesis To summarise two or more papers in narrative form Generic Unspecified/ Selective Not specified Not Specified Unspecified Review articletype report NO Metaethnography The generate new knowledge /theory use processes of interpretation Findings of qualitative research studies Not comprehensive or exhaustive; seeks saturation – theoretical sampling Opposed; all studies included as each may provide insight into the phenomena of interest Extraction of key concepts Refutational synthesis; Reciprocal translation; Line of argument synthesis. Higher order interpretation of study findings NO (Although QARI can be used) Approach Purpose Evidence of Interest Search Strategy Critical Appraisal Data Extraction Method of Synthesis Outcome Software Available Realist Synthesis To develop and test program theories Generic; but more suited to qualitative research studies Not comprehensive or exhaustive; seeks saturation Not specified Extracts positive and negative mechanisms/stra tegies that influence change Tacit testing of implicit theories; building theory. A transferable theory on “what works, for whom, in which circumstances” NO Thematic analysis To aggregate findings of 2 or more studies Findings of qualitative research studies Not comprehensive or exhaustive; seeks saturation – theoretical sampling Not specified Extracts of major/recurrent themes in literature Aggregation of themes/ metaphors/ categories A summary of findings of primary studies under thematic headings NO (Although QARI can be used Approach Purpose Evidence of Interest Search Strategy Critical Appraisal Data Extraction Method of Synthesis Outcome Software Available Content analysis To analyse then summarise content of papers.; occurrences of each theme counted and tabulated Generic Usually comprehensive with predetermined search strategy Not specified Content extracted then coded using extraction tool designed to aid reproducibility coded data categorised under thematic headings; also counted and tabulated A summary of findings, and their rate of occurrence, of primary studies under thematic headings YES Metasynthesis/ Metaaggregation To aggregate the findings of included studies Findings of qualitative research studies Comprehensive; detailed search strategy at protocol stage required Required, using standardised critical appraisal instrument Extraction of findings PLUS data that gives rise to finding using data extraction instrument Aggregation of findings into categories; and of categories into synthesised findings Synthesised findings that inform practice or policy in the form of a standardise d chart YES Meta-synthesis: worked examples Meta aggregation Meta ethnography Meta aggregation • A structured and process driven approach to systematic review drawing on the classical understandings and methods associated with systematic review of quantitative literature as practiced by the Cochrane Collaboration Meta aggregation • Based on an a-priori protocol – Established, answerable question – Explicit criteria for inclusion – Documented review methods for searching, appraisal, extraction and synthesis of data Meta aggregation • Explicitly aligned with: – Philosophy of pragmatism • Delivers readily useable findings • Informs decision making at the clinical or policy level – Transcendental phenomenology • Looks for common or “universal” essences of meaning • Attempts to “bracket” pre-understandings of the reviewer Transcendental Phenomenology • Based on the philosophic traditions of Husserlian phenomenology: – the intuitive examination of essences that have immediate validity; – Seeks to avoid undue influence of the reviewer on the text; – Seeks to generate practice level theory that has explanatory power for policy or practice – Seeks to preserve the intended meaning of text The needs and experiences of people with a diagnosis of skin cancer: a systematic review Janet Barker, Arun Kumar, Wendy Stanton and Fiona Bath-Hextall, JBI Library of Systematic Reviews, 2011; 9(4):104-121 Inclusion Criteria • Participants – Adults with a diagnosis of skin cancer. • Phenomena of Interest – The needs and experiences of people with skin cancer. • Context – Hospital or community-located dwellers. • Types of studies – All qualitative studies that described or analyzed the needs and experiences with people who had been diagnosed with skin cancer. Methods • Each paper was assessed independently by two reviewers for methodological quality. The internal validity (quality) of research papers was assessed using JBI-QARI. • There were no disagreements between the two reviewers and therefore a third reviewer was not required. Results Results ( cont/…) • A total of 12 findings were extracted from the 2 included qualitative papers • These findings were aggregated into 4 categories on the basis of similarity of meaning. • The categories were synthesized to generate 2 synthesized findings. Results/cont.. • The 2 studies used a qualitative approach but neither specified a particular methodological approach. • Both studies were conducted in the United Kingdom (UK), using semi structured interviews. Recommendations arising • There is a real need to increase knowledge of skin cancer so that people do not delay in seeking medical help as early diagnosis can dramatically improve both prognosis and the patient experience since early lesions are treated more simply compared with larger or neglected lesions. • Health professionals caring for these patients need to understand the psychosocial concerns of this patient group in order to design services appropriately and to provide patients with the support they need and information that they can easily understand. Meta-Ethnography • Explicitly aligned with philosophy of interpretivism • Searches for new meaning • Focuses on multiple realities Hermeneutic Interpretivism • Is the basis for meta-ethnography – Interpretation of text for its inner meaning – Focuses on the reviewers interpretive skills – Seeks to re-interpret the published literature – Seeks to generate new, mid level theoretical explanations – Seeks engagement between reviewer and text Meta ethnography • From within the social sciences to develop theories from existing ethnographic data, • Iterative development of emic interpretations, • Incorporates 7 phases, these can be aligned to the systematic review process, but there is no requirement to do so. Meta ethnography • • • • • • • Identify the research interest Decide which studies to include Read the studies Determine how the studies are related Translate the studies in to each other Synthesize the translations Express the synthesis Meta ethnography: 3 stages of synthesis • First order interpretations – Themes, metaphors or concepts identified • Second order interpretations – The researchers interpretation of how the identified concepts relate to each other • Third order interpretations – Seeks to encompass themes within each other Interpretation Second Order Interpretation: • Reciprocal – Like interpretations are brought together “this one is like that one..” • Refutational – Competing discourses; must also have a relationship that can be explored Third Order Interpretation: • Line of argument – Asks what do the parts infer about the whole Patient adherence to Tuberculosis treatment Salla A. Munro, Simon A. Lewin, Helen J. Smith, Mark E. Engel1, Atle Fretheim, Jimmy Volmink. ‘Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research’. PLoS Medicine July 2007. Inclusion criteria • Patients, carers or health professionals delivering DOTs • Perceptions of adherence was the phenomena of interest • Context was patients undergoing DOTs therapy for TB • Qualitative studies on the perception of adherence Methods • Studies were assessed using a checklist • Data extracted using a standardized form • Synthesis was reciprocal and line of argument Results • • • • • Following screening, 44 papers were included First order interpretations 8 Second order interpretations 6 Third order interpretations 4 Expression of the synthesis: visual model Recommendations • Increase visibility of TB programs in the community, which may increase knowledge and improve attitudes towards TB • Provide more information about the disease and treatment to patients and communities • Increase support from family, peers, and social networks • Minimize costs and unpleasantness related to clinic visits. Increase flexibility/ patient autonomy META ETHNOGRAPHY QARI METAGGREGATION FIRST ORDER ANALYSIS SECOND ORDER INTERPRETATION THIRD ORDER INTERPRETATION STEP 2: CATEGORIES STEP 3: SYNTHESISED FINDINGS Session 3: Critical Appraisal of Qualitative Evidence 1004 references 172 duplicates 832 references Scanned Ti/Ab 715 do not meet Incl. criteria 117 studies retrieved 82 do not meet Incl. criteria 35 studies for Critical Appraisal Why Critically Appraise? • Combining results of poor quality research may lead to misleading understandings of issues explored The Critical Appraisal Process • Every JBI review must set out to use an explicit appraisal process. Essentially: – A good understanding of philosophical perspectives, methodologies, methods is required in appraisers; and – An agreed instrument/checklist should be used. Validity, Reliability and Generalizability • Judging the quality of qualitative research remains deeply contested Analogous criteria for paradigmatic assumptions Quantitative Qualitative Reliability Dependability Internal Validity Credibility External Validity Transferability Reliability/dependability • Appropriateness of methodology, methods and implementation of the research methods, regardless of paradigm • The focus of dependability is on achieving consistent quality rather than repeatability. Internal validity/credibility • Credibility addresses whether a finding has been represented correctly – Assessment of credibility is multi-dimensional, including goodness of fit and representativeness, – Credibility is auditable - the process may be based upon researcher confirmation, member checks, peer checks, second researcher analysis, or observation. External validity/transferability • Findings are not generalizable in the quantitative sense of the word – generalization is “narrowly conceived in terms of sampling and statistical significance.” – “qualitative research is directed toward naturalistic or idiographic generalizations, or the kind of generalizations made about particulars” – Schofield (1990) describe qualitative metasynthesis as “cross-case generalizations created from the generalizations made from, and about, individual cases.” Sandelowski et al(1997) Critical Appraisal • General acceptance of need for quality • Ongoing debate around the role of appraisal • Particular focus of debate on role of scales and sum scores in appraisal • In practice, appraisal instruments for qualitative research tend to focus on establishing the degree to which the evidence applies to practice (transferability) rather than internal validity (credibility) The premise • Methods applied during the systematic review of qualitative evidence should firstly be congruent with the universally accepted process of systematic review. • The characteristics of a systematic review might be debated in terms of the detail, but there is general acceptance of a series of steps, stages or processes The Joanna Briggs Approach • Establishing credibility in qualitative research requires: – A standardized approach that is clearly defined, articulated, and applied, and • Takes in to consideration the relationship between: – Methodology and methods – Methods and data – Data and conclusions The Qualitative Assessment and Review Instrument (QARI) • QARI provides a systematic process mirroring that of systematic reviews of quantitative research whilst sensitive to the nature of qualitative data. • a significant proportion of qualitative work is not designed to address questions or issues of an immediate practical nature • this is consistent with the traditions of many qualitative methodologies • JBI focuses on evidence to improve global health, reviews with a clinical or policy focus are encouraged. Critical Appraisal in JBI-QARI Critical Appraisal of Interpretive Research • In interpretive and critical inquiry validity relates to the rigor of the process of inquiry – limiting bias to establish validity in the appraisal of quantitative studies is antithetical to qualitative approaches to inquiry • QARI incorporates a checklist to appraise rigor generically Group Work 2 • Read the 2 papers provided and then undertake critical appraisal of the paper using the JBI Critical Appraisal Checklist for Interpretive and Critical Research. • Report Back • Enter the details into JBI QARI Session 4: Data Extraction Study data and Data Extraction 1004 references 172 duplicates 832 references Scanned Ti/Ab 117 studies retrieved 35 studies for Critical Appraisal 26 studies incl. in review 715 do not meet Incl. criteria 82 do not meet Incl. criteria Data most frequently extracted Considerations in Data Extraction • • • • • • • • • • Source - citation and contact details Eligibility - confirm eligibility for review Methodology - approach to the inquiry Methods - how data were collected Phenomena of Interest - the described experience or activity Setting - specific context of study eg, hospital Geographical location - region or country Culture - cultural characteristics of setting or participants Participants - demographic data such as gender, age etc Data analysis - analytic approach taken, eg thematic analysis etc Extracting Findings • The units of extraction in this process are specific findings (and illustrations from the text that demonstrate the origins of the findings); • In Meta-aggregation a finding is defined as: A conclusion reached by the researcher(s) and often presented as themes, metaphors, findings, concepts, conclusions etc; • Some papers may present themes and sub themes (or findings of the qualitative analysis at different levels); for such papers the reviewer will need to decide which of these levels represent authentic findings; however, only findings of one level should be extracted from a specific paper. • No matter what level is decided, the actual verbatim words of the researcher must be extracted. Extracting Illustrations • Meta-aggregation requires reviewers to also extract an illustrative excerpt that the researcher presents in support of that particular finding; • It is only necessary to extract one such supporting illustration; • The actual verbatim words the researcher uses as the illustration must be extracted. Assigning a Level of Credibility to Qualitative Evidence Levels of Credibility- Qualitative • Unequivocal - relates to evidence beyond reasonable doubt • Credible - those that are, albeit interpretations, plausible in light of data and theoretical framework. • Not Supported - when 1 nor 2 apply and when most notably findings are not supported by the data – Should not be included in synthesis to inform practice Day 2 Session 5: Data Analysis and Meta-synthesis General Analysis - What Can be Reported and How – What phenomena of interest has been evaluated – The meaningfulness/appropriateness/feasibility of the experience/activity – Contradictory findings and conflicts – Limitations of study methods – Issues related to study quality – The use of inappropriate definitions – Specific populations excluded from studies – Future research needs Meta-Synthesis • Analysis and synthesis of qualitative studies • Based on processed data • Aim of meta-synthesis – is to assemble findings; – categorize these findings into groups on the basis of similarity in meaning; – aggregate these to generate a set of statements that adequately represent that aggregation. Synthesis of the Results of Qualitative Studies • Differing methodologies, such as phenomenology, ethnography or grounded theory, can be mixed in a single synthesis of qualitative studies because the synthesis is of findings and not the data. • This is a critical assumption of meta-aggregation. Meta Synthesis vs Meta Analysis As qualitative studies differ from RCT, meta-synthesis utilizes a different approach from that used during meta-analysis. Both approaches provide an understanding based on populations, settings and circumstances Unlike meta-analysis, meta-synthesis deals in multiple realities and so provides but one interpretation of the phenomenon. Executing Meta Synthesis using QARI Assembling the findings • Once findings are extracted from all included papers; – The reviewer transitions from a focus on papers to a focus on assembling all of the findings – This is executed inside JBI-QARI Creating Categories • Categorization involves repeated, detailed examination of the assembled findings • The reviewer identifies groups of findings on the basis of similarity in meaning to create categories – A category “Name” is the element of analysis that appears in the synthesis and is therefore a full description that conveys the whole, inclusive meaning of the category; that comprehensively represents the meanings embodied in the findings it encompasses – A Category “Summary” is a brief explanatory statement created by the reviewer to assist interpretation and auditabililty. Allocating Findings to Categories Synthesized Findings • In meta-aggregation a synthesized finding is an overarching description of a group of categorized findings that allow for the generation of recommendations for practice. Creating Synthesized findings • Meta-aggregation of categories involves repeated, detailed examination of the assembled categories • The reviewer identifies groups of categories on the basis of similarity in meaning – A Synthesized Finding “Name” is the element of analysis that conveys the whole, inclusive meaning of the categories; and that comprehensively represents the meanings embodied in the findings it encompasses – A synthesized finding “Name” must also draw a conclusion or claim and communicate the probability of that conclusion or claim – A Synthesized Finding “Summary” is a brief explanatory statement created by the reviewer to assist interpretation and auditabililty. Creating Synthesized Findings – Can be stated propositionally as “if-then” statements • e.g. “If a patient is awaiting a final diagnosis, their relatives will sometimes feel as if they are not involved” – Preference for the indicatory form (i.e. suggesting or demonstrating the expedience or advisability of action emphasizing the probability of the claim) • “Relatives of patients awaiting a final diagnosis of brain death may feel as if they are not involved if strategies to include them are not pursued”. Allocating categories to synthesized findings Session 6: QARI Trial Program Overview Time 0900 0915 1030 1100 Overview of Day 1 Session 7: The systematic review of text and opinion Morning Tea Session 8: NOTARI Trial 1200 1230 1330 1500 1515 1615 1700 Session 9: Protocol Preparation Lunch Session 10: Protocol Presentations Afternoon tea Session 10: Protocol Presentations/cont… Session 11: Assessment and Summation End Session Overview • This module considers how to appraise, extract and synthesize evidence from qualitative studies and text and opinion papers. Session 7: The systematic review of text and opinion Text, Expert Opinion and Discourse – Narrative and text (e.g. review papers, discussion papers and policy documents) present information that arises out of experience or observation. Much of the resources drawn on to develop policy are narrative and textual in nature rather than the outcomes of formal research – The opinions of leaders, professional organizations and learned bodies draw on the collective wisdom of experienced experts and are often referred to for guidance in relation to policy making and professional practice • Expertise is highly regarded and is linked to the ability of an expert to “have to hand” information in a given area and is associated with the possession of large amounts of knowledge and fluency in applying this knowledge • Discourse refers the verbal interchange of ideas that is grounded in language and in the context within which it occurs. Discourse in the professional and public domains is a source of knowledge that can be used to inform policy and clinical decision making. Text, Expert Opinion and Discourse as Evidence for Policy and Practice • • Narrative, opinion, expertise and discourse often represent the best available evidence in areas where research is limited, or where the knowledge that is needed is generally generated through policymaking or other processes rather than through formal research This kind of knowledge cannot be ignored as legitimate sources of evidence for policy and practice • While this kind of evidence is not a product of “good” science it is empirically derived and mediated through the cognitive processes of health professionals or policy makers who have typically been trained to be analytical • The superior quality of evidence derived from research is not denied rather, in its absence, it is not appropriate to discount opinion as non-evidence The Narrative, Opinion and Text Assessment and Review Instrument (NOTARI) Critical Appraisal of Evidence arising out of Opinion and Text Critical Appraisal of Text and Opinion This focus on limiting bias to establish validity in the appraisal of quantitative studies is not possible when dealing with text and opinion • The assessment of validity within the JBI-NOTARI process focuses on: • examining the opinion; identifying the credibility of the source of the opinion; establishing the motives that underlie the opinion; and locating alternative opinions that give credence to it or, conversely, question it. Critical Appraisal of Evidence arising out of Text and Opinion Report Back Introduction to Data Extraction and Meta-synthesis Data Extraction Aims • Reduce –The findings of many publications into a single document • Summarise –Messages –Conclusions Extracting Conclusions • The units of extraction in this process are specific conclusion stated by the author/speaker and the text that demonstrate the argument or basis of the conclusion Assigning a Level of Credibility to Text and Opinion Levels of Credibility- Text and Opinion • Unequivocal - relates to evidence beyond reasonable doubt which may include conclusions that are matter of fact, directly reported/observed and not open to challenge • Credible - those that are plausible in light of an argument and theoretical framework. • Not Supported - when 1 nor 2 apply and when most notably conclusions are not supported by sound argument Meta-Synthesis • The aim of meta-synthesis is to assemble conclusions; categorise these conclusions into groups on the basis of similarity in meaning; and to aggregate these to generate a set of statements that adequately represent that aggregation. These statements are referred to as synthesised findings - and they can be used as a basis for evidence based practice. Session 8: NOTARI Trial Session 9: Protocol Development Session 10: Protocol Presentations Session 11: Assessment