Making and Erasing Memories
Richard L. Huganir
Department of Neuroscience
Johns Hopkins University School of Medicine
Howard Hughes Medical Institute

The Brain is a Network of 100 Billion Neurons

The Brain has Quadrillions of Synapses
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Synaptic Transmission
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Synaptic Plasticity at Synapses
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Synaptic Plasticity at Synapses
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Synaptic Plasticity at Synapses
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Synaptic Plasticity at Synapses
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Long-Term Potentiation
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Long-Term Depression
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Kibra
Regulation of Receptor Function

Beautiful Synapses

Cranial Window

Imaging Receptors in Live Mice
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Sensory Stimulation Recruits Receptors to Synapses
Control
Stimulation
0 hour 1 hour 2 hour 3 hour

Spatial Learning - Water Maze
Before Training After Training
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Fear Learning and Memory - Fear Conditioning
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Fear Extinction: a Form of Behavioral Therapy
Extinction Learning

Fear Extinction: a Form of Behavioral Therapy
Extinction Learning Extinction Retrieval

Fear Extinction: a Form of Behavioral Therapy
Extinction Learning Extinction Retrieval Relapse

Synaptic Plasticity During Fear Learning
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24 Hrs after Fear Learning
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7 Days after Fear Learning
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Positive Allosteric Modulators of mGluR1
PAM
Ro-0711401: 9H-xanthene-9-carboxylic acid
(4-trifluoromethyl-oxazol-2-yl)-amide

Kibra
Regulation of Receptor Function

Huganir Lab
Yoichi Araki
Shu-Ling Chiu
Monica Coulter
Kirsten Bombach
Min Dai
Graham Diering
Huaqiang Fang
Hana Goldschmidt
Ahleah Gustina
Lisa Hamm
Seok Heo
Ingie Hong
Natasha Hussain
Richard Johnson
Olof Lagerlof
Trisha Lala
Brain Loeper
Bian Liu
Richard Roth
Raja Sekhar
Kamal Sharma
Gek Ming Sia
Mengnan Tian
Alyssa Toda
Lenora Volk
Rebecca White
Yong Zhang