Brains & Gains
November 2013
Ralph H. B. Benedict, PhD, ABPP-CN
Professor of Neurology, Psychiatry and Psychology
University at Buffalo, SUNY
[In] most of the patients
affected by multi-locular
sclerosis whom I have had
occasion to observe … there
is marked enfeeblement of the
memory; conceptions are
formed slowly; the intellectual
and emotional faculties are
blunted in their totality. The
dominant feeling in the
patients appears to be a sort
of almost cheerful indifference
in reference to all things.
Jean-Martin Charcot (1877)
mesial temporal r = 0.42 [Sicotte 2008; Benedict 2009]
thalamus r = 0.75 [Houtchens 2007]
3rd ventricle r = 0.71
[Christodolou 2003; Benedict 2004]
Demyelination and
axonopathy
cerebral cortex r = 0.65 [Amato 2004; Benedict 2006; Tekok-Kilic 2007]
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5
6
7
Walking
Upper Extremity Function
Cognitive Ability
Depression
Job Loss
Reduced work hours
Demotion
Less Salary
Miss Promotion
Negative Work Events
Work Errors
Forgetting Appointments
Slow Work, Reduced
Productivity
Unequal Work Distribution
Social Difficulty
Employer
Patient
Coworker
Accommodations/Intervention
High Tech, Low Tech Aids
Overt, Covert Aids
Additional Time to Complete Tasks
Flexible Schedule
Cognitive
Impairment
Maintain Employment
Mild
Severe
Private Disability
Social Security Disability
Early Retirement
Hours Worked per Week
Income
Extra Time Spent Outside Work
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How to Monitor Clinical Status?
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www.BICAMS.net
Published
Collecting data/analysis
Discussion
USA
Canada
Portugal
Peru
Iran
UK
Belgium
Oman
Czech Republic
Italy
Ireland
Poland
Germany
Hungary
Romania
Austria
Australia
Slovenia
Egypt
Sweden
Estonia
Turkey
Lithuania
Brazil
Norway
Mexico
Columbia
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Why do some MS Patients Fare so Well?
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Cognitive Reserve
Exercise
Personality
Cognitive Retraining
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Dimensional models of personality: the five-factor model and the DSM-5
Timothy J. Trull, PhD; Thomas A. Widiger, PhD. Dialogues Clin Neurosci. 2013;15:135-146.
Adam J. Booth
Jonathan D. Rodgers
Carolyn E. Schwartz, Sc.D
Brian R. Quaranto
Bianca Weinstock-Guttman
Robert Zivadinov
Ralph H. B. Benedict
Active Cognitive Reserve Influences the Regional
Atrophy to Cognition Link in Multiple Sclerosis
In Press
Thank You
Bianca Weinstock-Guttman MD
Robert Zivadinov MD; Murali Ramanathan PhD
David Hojnacki MD; Channa Kolb MD
Margaret Bucello NP; Audrey Smerbeck PhD
Jonathan Rodgers PhD, Natalie Emmert BA