KU Alzheimer’s Disease Center— The Executive Director’s Perspective Anne Arthur, BSN, MS, APRN-BC KU Alzheimer’s Disease Center Executive Director www.kualzheimer.org Objectives • Discuss the history of the KU Alzheimer’s Disease Center (KU ADC) • Identify the accomplishments of the KU ADC since inception • Explore ways the KU ADC can support investigators History of the ADC • • • • • NIA-Division of Neuroscience Established in 1984 Goal: promote research network on AD 29 centers in the US National meetings twice a year Alzheimer’s Disease Centers (ADC)—29 Timeline 1985 1990 1995 2000 2005 2010 2015 KU ADC • Director: Russell Swerdlow • 7 Cores • Aims 1-Support AD, AD-related, and brain aging research projects 2-Provide advanced services that facilitate groundbreaking metabolism research KU ADC Structure Administrative Core Clinical Core Data Management and Statistics Core Neuropathology Core Education and Information Transfer Core Neuroimaging Core Mitochondria Genomics and Metabolism Core KU ADC-Specific Cores Administrative Core Leader: Russell Swerdlow, MD • Goals – Provides oversight to the KU ADC – Promotes AD, MCI and brain aging research • Pilot Program • Resource Request – Expands KUs base of clinical, translational and basic science investigators • Collaborative REsearch Workgroup (CREW) meetings Advisory Boards Internal Advisory Board Randy Nudo Carol Cleek Joseph Donnelly Paul Terranova Peter Smith Richard Barohn Steven Warren Susan Kemper Robert Krumlauf External Advisory Board Charles DeCarli Angela Jefferson Nigel Cairns Walter Kukull Thomas Montine William Jagust Teresa Radebaugh Projects Supported • 18 Federal – 2 P01 (Michaelis, Kouhlen) – 7 R01 (Burns, Williams, Berman, Zhu) • 15 Foundation • 5 Training awards • 11 Therapeutic trials – ADCS – Alzheimer’s Drug Discovery Foundation – Pharmaceutical Clinical Core Leader: Jeffrey Burns, MD • Goals – Cohort of nondemented, MCI and AD subjects – Support and encourage collaborative interdisciplinary studies • Data • Biological specimens • Clinical research infrastructure – Burns elected to National ADC Steering Committee and ADC Clinical Task Force Clinical Core • 400 well-characterized participants Normal MCI AD > 60 y.o. Any age Any age Enrolled to date 119 51 58 234 Goal 200 100 100 400 Age Total Clinical Core Evaluation Visit 1 Clinical Evaluation (CDR) Yearly Visit 2 Memory Testing Yearly Visit 3 Labs/ Physical Function Testing/ DEXA Every 3 years Data Collection • Clinical Evaluation – Clinical Dementia Rating (CDR) Scale – Neurological Exam • Memory testing Boston Naming Test Block Design Stroop Free and Cued SRT Letter Number Sequencing • Physical Function testing • DEXA scan MMSE Logical Memory I & II Digit Span Forwards/Backwards Category Fluency Trailmaking A & B Digit Symbol Specimen Collection • Processed and stored in the Biospecimen Shared Resource (BSR) Center Plasma Buffy Coat Platelets Serum Whole Blood Cell-free Plasma Cybrid Cell Lines DNA RNA National Alzheimer’s Coordinating Center (NACC) • • • • Established by NIA in 1999 Support all ADCs Database for clinical and neuropath data Partners – National Alzheimer’s Disease Cell Repository (NCRAD) – Alzheimer’s Disease Genetics Consortium (ADGC) • Free to investigators Data/Specimen Sharing KU ADC National Alzheimer’s Coordinating Center (NACC) National Cell Repository for Alzheimer’s Disease (NCRAD)/Alzheimer’s Disease Genetics Consortium (ADGC) Data Management and Statistics Core Leader: Jonathan Mahnken, PhD • Goals – Provide statistical expertise – Develop Data and Information Management and Monitoring Systems • Mahnken elected to NACC Scientific Review Committee 2011-2014 • Present national ADC meeting 10/2012 Neuropathology Core Leader: Kathy Newell, MD • Goals – Autopsy human brain tissue from Clinical Core participants – Autopsy animal models – Neuropathological consultation and specimen sharing Scanning and Imaging Aperio Digital Scanning System Nikon Eclipse 80i + Metamorph Brain Autopsy Program • Clinical Core participants • Demented/non-demented brains • Neuropathology Case Conference – 2nd Thursday odd months, 4-5p, 1605 Surgical Pathology, Microscope Room 2 Education & Information Transfer Core Leader: Heather Anderson, MD • Goals – Recruit/retain subjects • KU ADC Clinical Core cohort • Clinical Trial Unit (CTU) – Train students and health professionals – Increase awareness of AD and the KU ADC Recruitment/Retention • Presentations • Newsletters • Social Media – Facebook – Twitter – Electronic newsletter • Birthday Cards • Annual Appreciation Breakfast Recruitment Sources GrayHawk Other Public Brochure Health Care Professional KU ADC Website Newspaper Ad Friend Family TV Radio Recruitment Flow Ed Core Clinical Trial Unit Clinical Core InvestigatorInitiated studies Education/Outreach • Seminar Series on Health, Aging and Dementia – Partner with LCOA and GPGEC • Alzheimer’s and Aging Research Colloquium – Partner with LCOA and GPGEC • Healthy Aging Symposium – Partner with JCCC • Annual Appreciation Breakfast • Lectures/presentations • Student observership Neuroimaging Core Leader: William Brooks, PhD • Goals – Advanced scientific support and subsidized scans for AD research – Advanced training and education in imaging – Develop novel imaging techniques for studies in AD Hoglund Brain Imaging Center • Instrumentation – 3 Tesla Siemens Skyra human MRI scanner – 9.4T Varian/Agilent animal MRI scanner – PET/CT Scanner (General Electric DST) (including cyclotron CTI (Siemens RDS 111) – 151-channel whole-head CTF MEG unit (including simultaneous 160 channel EEG) Novel Imaging Techniques • Translation of imaging protocols to new 3T scanner • Glutathione (GSH) spectroscopic imaging sequence • Vitamin C spectroscopic imaging sequence under development • Neurochemical profile from MRS Mitochondrial Genomics & Metabolism Core Leaders: Eli Michaelis, MD, PhD & Mary L. Michaelis, PhD • Goals – Prepare mitochondria, protein extracts, DNA, and RNA – Prepare cybrid cell lines – Perform mtDNA sequencing and 8-OH-2-dG measurements – Assist in AD mitochondrial research Support for Investigators • Pilot Grant Program • Resource Requests • Collaborative REsearch Workgroup (CREW) Meetings Pilot Grant Program • 3-4 grants awarded annually (July 1st) – Dr. Nudo, Landon COA, funded 1 project yr 1 & 2 • $30,000 awarded/grant • RFA 2nd week in December • New and established investigators eligible to apply • Contact: Eric Vidoni, PhD Resource Requests • Investigators conducting research on aging, MCI and AD can apply – Consultation – Services – Research materials • http://www.kualzheimers.org/alzheimersdisease-center/researcherresources/researcher-resource-request.html Biospecimen Resources • • • • • • Brain Tissue Buffy Coat Cell-free Plasma Cybrid Cell Lines DNA RNA • • • • • Muscle Plasma Platelets Serum Whole Blood Database Access • Alzheimer’s Disease Neuroimaging Initiative • National Alzheimer’s Coordinating Center • Kansas University Brain Aging Project Metabolism & Mitochondria Resources • Physical fitness, glucose tolerance, metabolic rate, and body composition testing • Structural brain neuroimaging of humans and animals • Metabolic neuroimaging of humans and animals (FDG PET, AV-45 and MRS) • Biochemical assays • Mitochondria, protein extracts, DNA, and RNA • Cybrid cell lines • mtDNA sequencing and 8-OH-2-dG measurements CREW Meetings • Collaborative REsearch Workgroup (CREW) meetings • 3rd Monday of every month in Clinical Research Center • All investigators in aging and dementia welcome to attend How you can help • • • • • Refer study participants Collaborate with us Spread the word Cite us Complete REDCap survey for any KU ADCaffiliated publications, presentations, etc. https://redcap.kumc.edu/surveys/?s=Tpmj5i KU ADC Team Administrative Core Russell Swerdlow, MD Jeffrey Burns, MD Anne Arthur, APRN Eric Vidoni, PhD Brad Amstein, BS Clinical Core Jeffrey Burns, MD Anne Arthur, APRN Russell Swerdlow, MD Heather Anderson, MD David Johnson, PhD Phyllis Switzer Hilary Dubinsky, BS Diane Cunningham Ashley Thompson Education and Information Transfer Core Heather Anderson, MD Angela Van Sciver Mitochondrial, Genomics and Metabolism Core Eli Michaelis, MD, PhD Mary Lou Michaelis, PhD Russell Swerdlow, MD Xinkun Wang, PhD Data Management and Statistics Core Jonathan D. Mahnken, PhD Hung-Wen (Henry) Yeh, PhD Russ Waitman, PhD Bhargav Adagarla, MS Suzanne Hunt, MS Cathy Price, BS Mani Nair, MS, MBA Megan Parks, AA Dan Connolly, BS Alexandra Brown, BS Neuropathology Core Kathy Newell, MD Cynthia Gouvion Neuroimaging Core William Brooks, PhD In-Young Choi, PhD, MR Phil Lee, PhD, MR Laura Martin, PhD Cary Savage, PhD Reg Dusing, MD How to Contact KU ADC KU Alzheimer’s Disease Center (913) 588-0555 kuamp@kumc.edu www.kualzheimer.org Research Requests http://www.kualzheimers.org/alzheimers-diseasecenter/researcher-resources/researcher-resource-request.html Data Core http://biostatistics.kumc.edu