“ Rapid diagnosis must lead to the rapid initiation of an appropriate treatment Web-Based Tools to Maximize a National Investment in the GeneXpert Jeff Takle, Dir. of Innovation @Abt Associates 2nd African Regional Training Workshop on Xpert MTB/RIF July 24, 2013 How Does it Work? Targeted alert messages USB modem, Wifi, Mobile phone, Manual upload Web database eTB Manager or M&E tools Electronic patient records Abt Associates There Are Four Stable, Scaling-up Data Services Around the GeneXpert GxAlert – Open source, dev in 2012 by Abt Associates – Incorporates diagnostics for TB and flu (GeneXpert) and HIV (PIMA) – Active in India and Nigeria; early stage in 5 countries TBGxMonitor – Developed in 2011 by Univ. of Witwatersand in South Africa – Active in South Africa; early stage in 13 countries XpertSMS – Open source, dev in 2011 by IRD Pakistan – Active in Pakistan, Nepal, Kenya, Zimbabwe; early stage in 5 countries RemoteXpert – Being developed by Cepheid, estimated launch December 2013 – Pilot tested in South Africa Abt Associates What Does Each Software Do? MOH Case+Population level Management Indicator reporting MDR treatment Drug demand / supply Integration into existing National Health Information Systems (eTB*) MOH messaging Clinic / lab messaging Patient messaging Labs External Quality Assurance (EQA) Instrument Verification Pre-analytical, analytical and post-analytical evaluation Errors and error rate (by user, module, and machine) TBGxMonitor RemoteXpert* Providers GxAlert XpertSMS GxAlert Cartridge expirations Stockout management Utilization vs. disease load Deployment planning Procurement, warranty, and service planning Abt Associates A Look Inside…GxAlert Abt Associates HIV Devices (PIMA) Can Report Directly into GxAlert Abt Associates Tracking Co-Infection Indicators at the Patient Level Abt Associates MOH Can Forecast Cartridge Needs By Observing Consumption Trends Avg. # tests/yr per device Utilization Rate of GeneXpert by Facility, Lifetime 438 100% 90% 80% 70% 60% Avg. Utilization per device 50% 40% 30% 20% 10% 0% 25% 24% 24% 16% 16% 13% 12% 6% 18% Est. Overpurchase in Year 1 -$103,114 Abt Associates MOH Can Identify Malfunctions Earlier and Reduce Patient Re-visits Number of Error Results, by Module A serious outlier Possible alert threshold Error Codes Abt Associates MOH Can Set Thresholds for Errors: Above = Alert to Supervisor Opportunity to identify “best practices” Focus attention where needed most Possible alert threshold Abt Associates A Look Inside…XpertSMS Abt Associates A Look Inside…XpertSMS Abt Associates A Look Inside…TBGxMonitor Abt Associates Each is Relatively Inexpensive to Bring to National Scale GxAlert ~$25,000 Yr1 to roll out nationwide and tech support existing software; Yr2 ~$10,000 XpertSMS ~$25,000 Yr1 to roll out nationwide and tech support existing software; Yr2 ~$10,000 TBGxMonitor available to complement NHLS/Wits DCS EQA program. Independent use cost TBD. Cepheid’s RemoteXpert, cost TBD, Dec 2013 Each of these software is capable of being connected with the others so installing a mix of software is possible Abt Associates Ways To Extend This Capability Connect to an EMR (OpenMRS) Connect to an M&E system Connect to a case management tool (eTB Manager) Connect to drug logistics program Connect other diagnostic devices (Hain, MGIT, PIMA) Automate portions of your indicator reporting Abt Associates Challenges Stable nationwide connectivity Security Stakeholder coordination Abt Associates Why Include These Tools in Your GeneXpert Implementation? 1. Patient benefits: start treatment faster, reduce spread of drug resistant disease, recover sooner 2. Identify and track population drug resistance patterns of TB cases 3. Shorten diagnostic response time from months to minutes, getting patients into treatment faster 4. Reduce waste and avoid stockouts through real-time forecasts 5. Dramatically improve data quality 6. Measure program adherence to the TB treatment protocols Abt Associates Acknowledgements MSH KNCV Nigeria NTP India private sector labs CHAI IRD Pakistan NHLS South Africa USAID CDC Abt Associates Better patient treatment Faster response to MDR-TB More efficient TB logistics Prepared by: Martha Benezet martha_benezet@abtassoc.com Jeff Takle jeff_takle@abtassoc.com Download slide deck @ www.GxAlert.com