Aggregate Exposures to Fragrances in Consumer

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GLOBAL
Expert Models for Decision Makers TM
Aggregate Exposure to Fragrances in
Consumer Products
Cian O’ Mahony, Head of Expert Modelling and Statistics
ISES 2014, Cincinnati
Fragrances
 3,000 + on the market
 Present in:
–
–
–
–
Personal care products
Cosmetics
Air care
Household products
 Previous models:
– Volume based
– Worst case concentrations and product
use (Cadby et. al 2002, SCCS 2012)
Fragrance Exposure
Exposure Model
• High-tier aggregate exposure model
Fragrance Data
• Based on real use levels by industry
• Representative of use levels on the
market
Exposure Model
 Over 36,000 consumers, EU and US
 Seven days of cosmetics and PCP use
and co-use
 Site of application recorded
 Amounts per application
 Body weights, heights and skin surface
areas
 Dermal and systemic exposure
 In a cloud-based software platform
2-PHENYLETHANOL (PEA)
EXPOSURE
Product Exposure
Approximate percentage contribution of individual products to the
95th percentile aggregate exposure (mg/kg bw/day).
SCCS Comparison
 PEA data:
– Upper point estimates for concentrations
– Dermal penetration 100%
 SCCS approach:
Systemic PEA Exposure – Consumers Only
Box and whisker plot of the chronic systemic PEA exposure by
product for consumers of these products only.
FRAGRANCE CONCENTRATIONS
Fragrance Concentration
Fragrance Concentration
Fragrance
Manufacturers
Fragrance Concentration
Consumer Product
Companies
Fragrance Concentration
Acknowledgements
 RIFM Exposure Task Force:
–
–
–
–
–
–
Anne Marie Api (RIFM)
Bob Safford (B-Safe Toxicology Consulting)
Catherine Clapp (Unilever)
Sarah Tozer (P&G)
Steve Robison (P&G)
Graham Ellis (Givaudan)
 Creme Global team:
–
–
–
–
–
Cronan McNamara (CEO)
Damien Comiskey (Project Manager)
EJ Daly (Software)
Roger Thomas (Software)
Viorica Botea (Software)
Publication
“Use of an aggregate exposure model
to estimate consumer exposure to
fragrance ingredients in personal care
and cosmetic products”
- Safford et. Al
- Submitted to Regulatory Toxicology
and Pharmacology in August
GLOBAL
Expert Models for Decision Makers TM
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