GLOBAL Expert Models for Decision Makers TM Aggregate Exposure to Fragrances in Consumer Products Cian O’ Mahony, Head of Expert Modelling and Statistics ISES 2014, Cincinnati Fragrances 3,000 + on the market Present in: – – – – Personal care products Cosmetics Air care Household products Previous models: – Volume based – Worst case concentrations and product use (Cadby et. al 2002, SCCS 2012) Fragrance Exposure Exposure Model • High-tier aggregate exposure model Fragrance Data • Based on real use levels by industry • Representative of use levels on the market Exposure Model Over 36,000 consumers, EU and US Seven days of cosmetics and PCP use and co-use Site of application recorded Amounts per application Body weights, heights and skin surface areas Dermal and systemic exposure In a cloud-based software platform 2-PHENYLETHANOL (PEA) EXPOSURE Product Exposure Approximate percentage contribution of individual products to the 95th percentile aggregate exposure (mg/kg bw/day). SCCS Comparison PEA data: – Upper point estimates for concentrations – Dermal penetration 100% SCCS approach: Systemic PEA Exposure – Consumers Only Box and whisker plot of the chronic systemic PEA exposure by product for consumers of these products only. FRAGRANCE CONCENTRATIONS Fragrance Concentration Fragrance Concentration Fragrance Manufacturers Fragrance Concentration Consumer Product Companies Fragrance Concentration Acknowledgements RIFM Exposure Task Force: – – – – – – Anne Marie Api (RIFM) Bob Safford (B-Safe Toxicology Consulting) Catherine Clapp (Unilever) Sarah Tozer (P&G) Steve Robison (P&G) Graham Ellis (Givaudan) Creme Global team: – – – – – Cronan McNamara (CEO) Damien Comiskey (Project Manager) EJ Daly (Software) Roger Thomas (Software) Viorica Botea (Software) Publication “Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products” - Safford et. Al - Submitted to Regulatory Toxicology and Pharmacology in August GLOBAL Expert Models for Decision Makers TM Thank you Name - Role Date