Spring USLA 2015 South Padre Island Texas Recommended Airport Harlingen International Airport South West airlines United Airlines Delta Airlines 42.2 Miles from South Padre Island Texas Driving Directions to Pearl South Padre From North: Take U.S. 77/83 southeast to exit Highway 100. Travel east to the end of Isabella Causeway, and the hotel is one block south of Padre Boulevard. From West: Take U.S. 77/83 southeast to exit Highway 100. Travel east to the end of Queen Isabella Causeway, and proceed south one block on Padre Boulevard. From South: Take Highway 48 northeast to junction Highway 100. Travel east to the end of Queen Isabella Causeway, and proceed one block on Padre Boulevard. General Information Room Rate : Activities: Attractions: Sea turtle inc. Sun set cruise Kite surfing Fishing National sea shore