Nompilo Study: Results of Evaluation Lisa M. Butler, PhD, MPH Division of General Pediatrics, Boston Children’s Hospital Department of Pediatrics, Harvard Medical School Presenting on behalf of the Nompilo Study Team: C. Horwood, W. Ngidi, M. Grant, J. Reddy, P. Barker, and N. Rollins Research Questions Implementing integrated community case management training & QI support to CHWs: • Is it feasible? • Does it lead to gains in CHW knowledge, selfefficacy and practice? • What is the effect on infant feeding practices, and uptake of PMTCT and MCH services? Setting and Design Setting: • Ugu District, KwaZulu Natal, South Africa Design: • Cluster randomized controlled trial • CHW supervisors (N=30), CHWs (N=120) • Mothers: ~8 mothers per CHW pre & post intervention 3 Participants and Timelines • CHW: • > 18 years old • Grade 9 education or greater • Employed by Department of Health to provide home support to pregnant women, mothers and children in Ugu District, SA • Mothers • > 18 years old • Delivered live-born infant in past 12 months • Reside in household assigned to participating CHW CHW: Baseline Mothers: PreIntervention 6 Months 12 Months PostIntervention Analytic Approach • Mixed-effects models • Interaction of treatment group with visit month tested for differences in rate of change between groups Results Participant Characteristics: CHW Characteristics Intervention CHW N=60 Control CHW N=60 P-value 39.3 (34.7-44.6) 38.5 (34.1-44.5) 0.91 Female 98.3% 100% 0.91 Education – completed secondary school 31.67% 31.66% 0.92 Experience as CHW: 4+ years 63.3% 61.7% 0.88 Age (years), Median (IQR) Self Efficacy • Significantly improved self efficacy at 6 and 12 months (intervention vs control CHWs): • Talking to a pregnant woman about HIV • Advising a pregnant woman about her own nutrition • Assisting a mother with breastfeeding • Explaining services available for PMTCT • Doing a postnatal visit to check the mother’s health & newborn baby • Recognizing danger signs in pregnancy, newborn or postpartum mother CHW Knowledge 80 P=0.28 P<0.0001 P<0.0001 70 Percent Correct 60 50 Control CHW 40 Intervention CHW 30 20 10 0 Baseline 6 Months 12 Months Participant Characteristics: Mothers Pre-Intervention 23 April 2012 to 3 August 2012 Age, Median (IQR) Control catchment Intervention catchment Total Control catchment Intervention catchment Total N=370 N=366 N=736 N=310 N=296 N=606 24 years (20 years to 30 years) 25 years (21 years to 30 years) 23 years (20 years to 29 yeas) 23 years (20 years to 28 years) 23 years (20 years to 29 years) 25 years (21 years to 30 years) P value = 0.48 At least some secondary level education 289 (78.1%) 272 (74.3%) P value = 0.93 561 (76.2%) P value = 0.65 Employed 32 (8.7%) 28 (7.8%) 30.0% 27.4% P value = 0.48 255 (82.3%) 220 (71.0%) 475 (78.4%) P value = 0.83 60 (8.2%) P value = 0.67 HIVpositive Post-Intervention 4 November 2013 to 31 March 2013 25 (8.1%) 22 (7.5%) 47 (7.8%) P value = 0.83 28.7% 27.5% 28.3% P value = 0.86 27.8% Mother report about CHW visits 100 90 80 70 60 50 40 30 20 10 0 Control Catchment Intervention Catchment Exclusive Breastfeeding in First 6 Weeks 100 Control Catchment Intervention Catchment 90 80 P = 0.15 P = 0.02 70 60 50 40 30 20 10 0 N=298 Time 1 N=305 N=256 Time 2 N=231 Care Seeking 35 30 Control Catchment P=0.16 Intervention Catchment P=0.02 P=0.33 25 P=0.02 20 15 10 5 0 Pre-Intervention Post-Intervention Did not seek care for self when needed in prior 6 months Pre-Intervention Post-Intervention Did not seek care for child when needed in prior 6 months Receipt of ANC, PNC, HIV and PMTCT services (post-intervention) 100 Control Catchment Intervention Catchment 90 80 70 60 50 40 30 20 10 0 Attended ANC HF birth PNC in 1st week Offered HIV test in pregnancy Referred for ART On ART when baby born Baby had PCR Received PCR test test Summary Compared to CHWs in control arm, CHWs in intervention arm: • Significantly greater level of self-efficacy • Significantly greater level of HIV and MCH-related knowledge • Knowledge regarding HIV/MCH content sustained over time Compared to mothers in control catchment, mothers in intervention arm: • Reported more frequent CHW visits and discussion about HIV/MCHN • Significant improvement in exclusive breastfeeding in first 6 weeks • Significant improvement in care-seeking for mothers and infants • No change in receipt of HIV testing or receipt of PMTCT services – but prevalence overall was very high Conclusions • Training approach and materials were effective in knowledge transfer and highly appreciated even though demanding; • QI supervision and support of CHWs was feasible and valued; • Improved CHW knowledge, self-efficacy and practices were sustained over time; • Some maternal behavior change observed, despite short period of intervention Nompilo Study Team 20,000+ Partnership • Dr. Jennifer Reddy (PI-intervention) • Wilbroda Ngidi • Khumbuzile Sishi • Ellen Ntswe • Lorraine Mkhize • Sandra Reid Centre for Rural Health, U. KwaZulu-Natal • Dr. Christiane Horwood (PI-evaluation) • Merridy Grant • Lyn Haskins • Sifiso Phakathi • Ntokozo Mntambo • Rosemary Brown World Health Organization •Dr. Nigel Rollins Institute for Healthcare Improvement •Dr. Pierre Barker •Dr. Kedar Mate Boston Children’s Hospital •Dr. Lisa M. Butler Acknowledgements Lenore Spies, Nutrition Manager, KwaZulu-Natal Department of Health Janet Dalton, KwaZulu-Natal Primary Healthcare Manager Victoria Mubaiwa, Maternal and Child Health Director, KwaZulu-Natal Department of Health Dr. Charles McCulloch, University of California San Francisco Dr. Henry Feldman, Boston Children’s Hospital Funders: •US Centers for Disease Control and Prevention •World Health Organization