Veterinary Drug Manual 2023

Updated-2023 1 Contributors Medicine Prof. Dr. Md. Rayhan Faruque Prof. Dr. Md. Mizanur Rahman Prof. Dr. Md. Yousuf Elahi Chowdhury Prof. Dr. Pankaj Chakraborty Dr. Suchandan Sikder Dr. Md. Ahaduzzaman Dr. Sharmin Akter Dr. Pranab Paul Dr. Sazeda Akter Surgery Prof. Dr. Bibek Chandra Sutradhar Prof. Dr. Bhajan Chandra Das Prof. Dr. Monoar Sayeed Pallab Dr. Tuli Dey Theriogenology Prof. Dr. Azizunnesa Dr. Anowar Parvez Dr. Tanjila Hasan Epidemiology Prof. Dr. Ahasanul Hoque Veterinary Surgeons Dr. Abdul Mannan Dr. Afzal Hossain Student contributors Updated-2019 by Shariful Islam Saikat (22nd) Updated-2023 by Mir Mohammad Junayed (19th) 2 Index Contents Antibiotics acting on different organs, systems or body parts Pregnancy safe Antibiotics Drugs contraindicated or unsafe during pregnancy Drug Interaction Antibiotic spectrum Withdrawal period of drugs Withdrawal period for Injectable antimicrobial drug Withdrawal period for common Intra Mammary antimicrobial drug Dosage Calculation equation Page 13 14 14 15 16 16 16 17 17 Farm Animal Medicine (18 ─ 125) Penicillins Cephalosporins Fluoroquinolones Tetracyclines Antibiotics and Antimicrobials Aminoglycosides Sulfonamides Macrolide Antibiotics Procaine penicillin G + benzathine penicillin G Procaine penicillin G + benzathine penicillin G + Streptomycin Ampicillin Amoxicillin Amoxicillin + Clavulanic acid Ceftriaxone Ceftiofur Enrofloxacin Marbofloxacin Ciprofloxacin Danofloxacin Oxytetracycline Gentamicin Neomycin Apramycin Sulphadimidine Sulpadiazine + Sulphadimidine + Sulphapyridine Sulphadiazine + Trimethoprim Sulphamethoxazole + Trimethoprim Tylosin Tilmicosin Metronidazole Nitroimidazoles Florfenicol Lincosamide Lincomycin and Spectinomycin Antibiotics Replacer /Antiviral Drugs used to treat mastitis (Intra-mammary preparations) Drugs used to treat Subclinical mastitis Antibiotic Eye drops 19 20 20 20 21 22 25 26 26 27 28 28 31 31 32 32 33 34 34 35 36 37 38 38 39 39 41 42 3 Antifungal drugs Antiparasitic drugs Autacoids Anti Glaucoma Eye drops Antibiotic Ear drops Antibiotic topical preparations Griseofulvin Ketoconazole Azoles Fluconazole Itraconazole Nystatin Topical anti-fungal preparation Whitfield’s ointment Piperazine Albendazole Antinematodal drugs Fenbendazole Mebendazole Levamisole Ivermectin Antitrematodal Oxyclozanide /Fasciolicidal drugs Oxyclozanide + Tetramisole Nitroxynil Triclabendazole Anticestodal drugs Niclosamide Antinematodal + Triclabendazole + Levamisole Antitrematodal Ivermectin + Clorsulon preparation Ivermectin + Triclabendazole Fly repellent (Trichlorfon, Metrifonate, Cypermethrin, DressgelFR) Antimony preparation Imidocarb dipropionate Antiprotozoal drugs Diminazine aceturate Buparvaquone Anticoccidial Amprolium agents Toltrazuril Pheniramine maleate Antihistaminic Chlorpheniramine maleate Diphenhydramine Promethazine Paracetamol Nonsteroidal AntiMeloxicam inflammatory Drugs Tolfenamic acid (NSAIDs) Flunixin Meglumine Metamizole Carprofen Others Steroidal AntiDexamethasone inflammatory Drugs Dexamethasone + Prednisolone (SAIDs) 43 43 43 45 46 46 46 46 47 47 48 48 50 50 51 52 52 53 53 54 54 55 55 56 58 59 60 60 61 62 62 63 63 63 64 65 66 67 67 68 68 69 70 4 Mucolyte, Expectorant, Antitussive and Brochodilator Diuretics Furosemide Mannitol Appetizers Stomachic’s and Digestive stimulants Rumenotorics Antizymotic & Digestive Stimulant Carminative Drugs for tympany & bloat Drugs used for Purgatives & Laxatives/ Intestinal stimulant digestive system Drugs for acidosis disorders Antidote Anti-spasmodic Drug for Stomatitis Anti-diarrhoeal Preparations Prebiotics and Probiotics Vitamin B Complex Thiamine Hydrochloride (B1) Nerve tonics Vitamin A, D, E preparations Vitamin preparations Vitamin C Vitamin D Vitamin E + Selenium Multivitamin preparations DB vitamins Nutritional Calcium preparations (Injectable) products Calcium preparations (Oral) Mineral preparations Zinc preparations Butaphosphan, Toldimphos, Cyanocobalamine Vitamin + Mineral + Amino acid Milk Increaser Amino Acid Liver tonics Hematinic mixtures Electrolytes Fluid therapy (IV Infusion) Atropine preparations Haemostats Utero-tonic Detergents, Antiseptics & Disinfectants Homeopathic drugs used in veterinary medicine Dairy tools 70 72 73 74 75 76 76 78 79 79 80 80 81 82 83 87 88 89 90 92 92 92 93 95 99 101 103 105 107 108 109 112 115 116 118 120 121 121 122 124 124 Pet Animal Medicine (126 − 186) A handy list of the top toxic people foods to avoid feeding your pet 126 5 Penicillins Broad-spectrum Aminopenicillins Cephalosporins Antibiotics Fluoroquinolones Tetracyclines Aminoglycosides Sulfonamides Macrolides Lincosamide Antifungal antibiotic Antiviral drugs Procaine penicillin G + Benzathine penicillin G Ampicillin Amoxicillin Amoxicillin + clavulanic acid Cefazolin st 1 generation sodium Cephalosporins Cephalexin Cefadroxil Cefaclor Cefuroxime 2nd generation axetil / Cephalosporins Cefuroxime sodium Cefixime rd th 3 and 4 Cefotaxime generation Cefpodoxime Cephalosporins Ceftriaxone Ceftiofur Cefepime Ciprofloxacin Enrofloxacin Marbofloxacin Doxycyline Amikacin Gentamicin Sulfamethoxazole/Trimethoprim Azithromycin Erythromycin Clindamycin Lincomycin and Spectinomycin Metronidazole Nitroimidazoles Antibiotic Eye drops Anti Glaucoma Eye drops Antibiotic Ear drops Antibiotic Topical preparations Griseofulvin Polyene Macrolide Antimicrobials Nystatin Ketoconazole Azoles Fluconazole Itraconazole Allylamines Terbinafine Topical anti-fungal Whitfield’s ointment preparation Zidovudine Acyclovir 127 127 128 128 129 130 130 131 131 132 132 132 133 134 134 135 136 136 137 137 137 138 139 139 139 140 140 141 141 141 141 141 142 142 143 143 144 144 145 145 6 Antiparasitic drugs Remdesivir Pyrantel pamoate Fenbendazole Mebendazole Praziquantel Ivermectin Ectoparasiticides Antiprotozoal drugs Antihistaminic Autacoids Nonsteroidal Antiinflammatory Drugs (NSAIDs) Steroidal Antiinflammatory Drugs (SAIDs) Selamectin Fipronil Amitraz shampoo Others Imidocarb dipropionate Diminazine aceturate Pheniramine maleate Chlorpheniramine maleate Diphenhydramine Promethazine Cetirizine Loratadine Fexofenadine Meloxicam Flunixin Meglumine Ketoprofen Tolfenamic acid Carprofen Dexamethasone Prednisolone Dexamethasone + Prednisolone Methylprednisolone Methylprednisolone Acetate Brochodilators/ Anti-asthmatic Drugs Furosemide Diuretics Mannitol Appetite stimulants & Antidepressant Gastric secretory inhibitors Proton pump inhibitor Mucosal cytoprotectants (gastroprotectant) Drugs Acting on the Gastrointestinal Tract Antiemetics Carminative/Anti-dyspeptic Drugs Laxative agents Mirtazapine Famotidine Ranitidine Omeprazole Pantoprazole Sucralfate Metoclopramide Ondansetron Domperidone Simethicone Docusate sodium Lactulose 145 146 146 147 147 148 148 149 149 150 151 152 152 153 153 153 154 154 154 155 155 155 156 156 156 157 157 157 158 158 159 159 160 160 160 161 161 162 162 162 162 163 163 163 7 Anti-diarrheal drugs Magnesium hydroxide/ aluminium hydroxide Antidote Bismuth Subsalilate Loperamide Anti-spasmodic Vincristine sulfate Antineoplastic Antidiabetic agents Amitriptyline Behavior Modifying Drugs Fluoxetine Uterine contractants Cabergoline Drugs Acting on the Central Nervous System Anticonvulsants Gabapentin Drugs Acting on Peripheral Nervous System Epinephrine (Adrenaline) Vitamin B Complex Nerve tonics Vitamin C Vitamin E Vitamin preparations Vitamin E + Vitamin C Vitamin K Multivitamin & Multimineral preparations Calcium Carbonate Calcium Carbonate + Vitamin D Mineral Preparations Nutritional Zinc preparations products Vitamin B Complex + Zinc Amino Acid Omega-3 fatty acid Liver tonics Iron dextran Ferrous sulfate Hematinic mixtures Cyanocobalamin + Elemental Iron + Folic Acid Electrolytes Fluid therapy (IV Infusion) Kidney Tonic Haemostats Atropine preparations ACI Pet care Detergents, Antiseptics & Disinfectants 164 164 165 165 165 166 166 167 167 167 168 168 168 170 170 171 171 171 172 172 172 173 173 173 175 176 180 181 181 181 181 181 183 183 184 186 Avian Medicine (187 − 243) Amino-penicillin Cephalosporin Amoxicillin Cefalexin 187 187 8 Quinolone Antibiotics and Antimicrobials Tetracyclines Aminoglycosides Sulfur drugs Macrolide antibiotic Nitroimidazoles Lincosamide Pefloxacin Enrofloxacin Ciprofloxacin Norfloxacin Danofloxacin Flumequine Oxytetracycline Chlortetracycline Doxycycline Doxycycline + Oxytetracycline Doxycycline + Neomycin Doxycycline + Trimethoprim Gentamicin Neomycin Sulphachloropyridazine + Trimethoprim Sulfadiazine + Trimethoprim Sulfamethoxazole + Trimethoprim Sulfur drugs + Erythromycin Tilmicosin Tylosin Tylosin tartrate & doxycycline Tylvalosin Tartrate Metronidazole Lincomycin and Neomycin Lincomycin and Spectinomycin Florfenicol Antibiotics Replacer /Antiviral Tiamulin Hydrogen Fumerate Tilmicosin Antimycoplasmal Tylosin tartrate drugs Tylosin Tartrate + Doxycycline Tylvalosin Tartrate Natural Coccidiostat Anticoccidial Sulfaclozine Na drugs Amprolium HCl & combined with others Toltrazuril Piperazine citrate Albendazole Anthelmintics Fenbendazole Levamisole Ivermectin Fly controllers Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Respiratory stimulants Diuretics 188 188 189 189 190 190 191 191 192 193 193 193 194 194 195 195 196 196 197 198 198 199 199 199 199 200 200 201 202 202 202 202 202 202 203 204 205 206 206 206 207 207 208 208 210 9 Anti Gout preparation Salmonella and other organism killer/ Ammonia controller Acidifiers Toxin neutralizers Toxin binder + Mold inhibitor Antioxidants Immune stimulators Vitamin B complex Vitamin B complex + Vitamin C Vitamin B complex & Amino acid Vitamin A, D, E preparations Vitamin preparations Vitamin D Vitamin E + Selenium Vitamin K Vitamin C Vitamin C + Glucose Zinc preparations Mineral preparations Calcium preparations Nutritional Di-Calcium Phosphate products Multimineral preparation Vitamins + Mineral + Amino Acids Amino Acid Feed premix Egg formula Growth promoters Prebiotics and Probiotics Enzymes Choline Phospholipid Lecithin Lysolecithin Hematinic mixtures Electrolytes Liver tonics Hepatorenal preparations Antiseptics & Disinfectants 211 211 212 213 214 216 216 217 218 219 219 220 220 221 222 222 223 224 225 226 226 229 229 231 232 232 234 236 237 237 237 238 239 241 242 Rabbit medicine (244 − 249) Fish Medicine (250 − 263) Amino-penicillin Quinolone Antibiotics and Antimicrobials Natural Coccidiostat Anthelmintic Aminoglycosides Tetracycline Sulphonamides Ivermectin Amoxicillin Ciprofloxacin Pefloxacin Neomycin Oxytetracycline Sulfur drugs + Erythromycin 250 250 250 250 251 251 251 252 10 Ammonia reduction Control Unwanted Fish Control pH of water Aqua Probiotics Phytoplankton Grower Di-Calcium Phosphate Nutritional Phospholipid products Multivitamin Feed Premix Electrolytes Lecithin Lysolecithin Vitamin C + Glucose Betaine Hydrochloride Sanitizer Hormonal drugs (264 − 268) Estrogen Progesterone GnRH Prostaglandin FSH LH Oxytocin 264 264 264 265 266 267 267 Anesthetics (269 − 279) a. Anticholinergics b. Benzodiazepine Atropine sulphate Diazepam Midazolam Xylazine Preanesthetics c. Alpha 2 adrenergic d. Opioid analgesics A. Barbiturates General anesthetics 1. Injectable anesthetics 2. Inhalation anesthetics Local anesthetics B. Nonbarbiturates C. Dissociative anesthetic Isoflurane Halothane Phenobarbital Thiopental Sodium Propofol (Phenol derivative) Ketamine Benzocaine Lidocaine Bupivacaine Prilocaine Vaccines Vaccines of Livestock Research Institute (LRI), Mohakhali 252 254 254 254 257 258 258 259 259 259 262 262 263 269 270 270 271 271 274 274 275 275 276 277 277 277 278 279 (280 − 299) Vaccine against Foot & Mouth Disease Vaccine against Anthrax 281 281 11 Farm animal vaccines Commercial preparations Vaccine against Black Quarter Vaccine against Haemorrhagic Septicaemia Vaccine against PPR Vaccine against Goat Pox Vaccine against Rabies Vaccines of Indian Immunologicals Limited Vaccines of Incepta Vaccines of Square Pharmaceuticals Vaccines of Bengal Overseas Vaccines of ACI Canine vaccination schedule Feline vaccination schedule Pet animal vaccines Commercial preparations Poultry vaccines References Vaccines manufactured by Intas Pharmaceuticals LTD. Vaccines of Bioveta Vaccines of Merck Animal Health Vaccines of Square Pharmaceuticals Vaccination schedule Vaccines of Livestock Research Institute (LRI), Mohakhali Commercial preparations Vaccines of ACI Animal Health Vaccines of Renata 282 282 283 284 284 285 285 286 286 287 288 288 289 289 290 290 291 291 294 297 300 12 Antibiotics acting on different organs, systems or body parts: 13 Pregnancy safe Antibiotics 1. Penicillins 2. Cephalosporins 3. Monobactam 4. Carbapenems 5. Vancomycin 6. Macrolides 7. Clindamycin 8. Quinolone (Not Fluoroquinolones) 9. Rifampin 10. Nitrofurantoin Drugs contraindicated or unsafe during pregnancy Nota Bene: This list is not comprehensive; absence from the list does not imply safety. Groups of Drug Contraindicated Drugs Unsafe Drugs Antibacterial Fluoroquinolones, Cotrimoxazole, Macrolides, Tetracyclines: tetracycline, doxycycline. Clindamycin, Gentamycin, Chloramphenicol, Aminoglycosides Vancomycin 14 Anti-tubercular Anti-malarial Anti-amoebic Anthelmintic Antifungal Antiviral Antihypertensive Sulfadoxine, Primaquine Tinidazole Albendazole, Mebendazole, Diethylcarbamazine Amphotericin B, Ketoconazole, Itraconazole, Griseofulvin Ganciclovir, Amantadine, a-interferon, Vidarabine, Foscarnet ACE inhibitors, Angiotensin-Il receptor blockers Sulfonylureas, Metformin, Acarbose Pyrazinamide, Ethambutol Mefloquine, Pyrimethamine, Artemeter, Artesunate. Metronidazole Pyrantel Fluconazole, Terbinafine Acyclovir Thiazides, Frusemide, Propranolol, Na-Nitroprusside. Antidiabetic Pioglitazone, Rosiglitazone, Repaglinide, Nateglinide Analgesic Morphine Pethidine, Tramadol, Aspirin, Indomethacin, Codeine, COX-2 inhibitors, Dextropropoxyphene, NSAIDs, Metamisole. Antiemetic Domperidone Ondansetron Anti PUD Lansoprazole, Cisapride Omeprazole, Pantoprazole, Mosapride, Cimetidine. Laxative Senna, Bisocodyl, Saline purgatives. Antidiarrhoeal Diphenoxylate Antipsychotic Fluphenazine Chlorpromazine, Clozapine, Olanzapine, Risperidone, Na-valproate Antidepressant Trimipramine, Dothiepine Citalopram, Paroxetine, Trazodone Anticoagulant Warfarin, Phenindione Acenocoumarin Antiasthmatic Ketotifen Theophylline, Montelukast, Zafirlukast, Systemic corticosteroids. Antithyroid Radioactive lodine Carbimazole, lodine. Reference: A Compandium of Veterinary Medicine by Dr. A.K.M. Saifuddin & Dr. Abu Bakar (Ahad) Drug Interaction Drug Penicillin Cephalosporins Fluoroquinolones Aminoglycosides Tetracyclines Antagonist a. Bacteriostatic antibiotics (e.g., chloramphenicol, erythromycin, tetracyclines): a. Aminoglycosides, b. nephrotoxic drugs, c. calcium a. Antacids/dairy products containing cations (Mg++, Al+++, Ca++), b. cyclosporine a. Nephrotoxic drugs, other (cisplatin, amphotericin b, polymyxin B, or Vancomycin) b. Neuromuscular blocking agents & anesthetics, general c. Diuretics, loop (e.g., furosemide, torsemide) or osmotic (e.g., mannitol) d. NSAIDS a. Beta-lactam, aminoglycoside antibiotics, 15 Sulfonamides Macrolide Antibiotics: Erythromycin Lincosamides: Clindamycin Colistin Metronidazole Trimethoprim b. Antacid, c. aluminum, calcium, iron, magnesium, zinc, or bismuth cations Antacids Clindamycin, Penicillin, Lincomycin Erythromycin Cephalosporins, Aminoglycosides, Anesthetics Phenobarbital, Phenytoin Thiazides or furosemide Drug Penicillin Fluoroquinolones Synergistic effects Aminoglycosides aminoglycosides, 3rd-generation cephalosporins, Extended-spectrum penicillin. Antibiotic spectrum Broad spectrum Bacteriostatic✓ Tetracyclines ✓ Sulfonamides ✓ Chloramphenicol Bactericidal✓ Aminoglycosides ✓ Fluoroquinolone ✓ Nitromidazoles (metronidazole) ✓ Nitrofurans (Furazolidone) ✓ Cephalosporin ✓ Penicillin (amoxicillin, ampicillin, amoxicillin+clavulanic acid, etc.) ✓ Refamycin (rifampicin) Narrow spectrum Bacteriostatic✓ Lincosamides (Lincomycin, Clindamycin) ✓ Macrolides Bactericidal✓ Penicillin (Penicillin G, V, procaine penicillin,etc.) ✓ Quinolone- (nalidixic acid, Oxolinic acid) ✓ Polypeptides (colistin,polymixin B, Vancomycin, Bacitracin) Withdrawal period of drugs Antibiotic Amoxicillin Ampicillin Penicillin (Procaine) Gentamicin Oxytetracycline Sulfadimethoxine Tylosin Ciprofloxacin Ceftrioxone Streptomycin+Penicillin Neomycin Withdrawal period (Days) in meat 25 6 3 40 28 7 21 23 24 2 1-3 Withdrawal period (hours) in milk 60-96 48 60 72 96 60 0 24 0 0 Not established Withdrawal period for Injectable antimicrobial drug Drug Amoxicillin Streptomycin Penicillin G (Procaine) Sulfamethiazine Cattle 25 days 2 days 3 days 12 days Swine -30 days 6-7 days -- Chicken -4 --- Milk discard 96 hours 0 60 hours -- 16 Sulfamethoxypyridazine Gentamicin Oxytetracycline Tylosin Ampicillin Ceftiofur Ciprofloxacin Pefloxacin Sulfadimidine Chlortetracycline Ampicillin 7 days -28 days 21 days 6 days 4 days 15 days 1 days 6 days 4 days 40 days 28 days 14 days 15 days 4 days 5 days - -35 days 7-14 days 3 days -0 days 7 days 5 days 15 days 3 days 6 days --96 hours -48 hours 0 days - Withdrawal period for common Intra Mammary antimicrobial drug Drug Lactating milk Milk discard Penicillin G (Procaine) 3-4 days 60-84hours Oxytetracycline 4 days 96 hours Dihydrostreptomycin 60days 24-96 hours post calving Cloxacillin 10 days 48 hours Amoxicillin 12 days 60 hours Erythromycin 0-14 days 36 hours Ref.: Veterinary pharmacology and Toxicology, B.K. Roy (page no. 400) & Handbook of Veterinary Pharmacology (Walter H. Hsu) Dosage Calculation equation Dose (ml) = Example: A 560-kg horse requires 6.6 mg/kg of Strongid T (50 mg/ml)- 𝐵𝑜𝑑𝑦 𝑤𝑒𝑖𝑔ℎ𝑡 (𝑘𝑔) × 𝐷𝑜𝑠𝑎𝑔𝑒 (𝑚𝑔⁄𝑘𝑔) Dose = 560 𝑘𝑔 ×(6.6 𝑚𝑔⁄𝑘𝑔) 50 𝑚𝑔⁄𝑚𝑙 𝐷𝑟𝑢𝑔 𝑐𝑜𝑛𝑐𝑒𝑛𝑡𝑟𝑎𝑡𝑖𝑜𝑛 (𝑚𝑔⁄𝑚𝑙 ) Dose = 3696 𝑚𝑔 50 𝑚𝑔⁄𝑚𝑙 Dose =73.92 ml So, Give 74 ml (3700 mg). 17 Farm Animal Medicine Antibiotics and Antimicrobials Antibiotic: Chemical produced by a microorganism/synthetically that kills or inhibits the growth of microorganism at very low concentration, does not cause any harm or minimum harm to host. The first antibiotic was discovered by Alexander Fleming in 1928 in a significant break through for medical science. Antimicrobial agent: Chemical that kills or inhibits the growth of microorganisms. Classification of Antimicrobials Inhibit cell wall synthesis Alter nucleic acid metabolism Penicillins Rifamycins Cephalosporins Quinolones Carbapenems Monobactams (aztreonam) Vancomycin Inhibit protein synthesis Inhibit folate metabolism Chloramphenicol Trimethoprim Tetracyclines Sulfamethoxazole Macrolides Clindamycin Miscellaneous Aminoglycosides Metronidazole Streptogramins Daptomycin (quinupristin/dalfopristin) Oxazolidinones (linezolid) Mechanism of actions Penicillins Mode of action: Acts on bacterial cell wall → Inhibit transpeptidase → Hamper the cross linking (Peptidoglycan layer) of rapidly multiplying organisms → Cell wall deficit form is produced →Hyper- 18 osmotic environment in the anterior of bacteria → Due to the action of autolysin/murein swelling & bursting occur → Death of bacteria. (bactericidal activity) Recommended dosages for Penicillin: Drug Species Dose Route Interval (hr) Natural penicillins (Narrow) Procaine Cattle and other 10,000-40,000 IU/kg IM, SC 24 penicillin G ruminants 44,000–66,000 IU/kg IM, SC 24 Benzathine penicillin G Procaine penicillin G + benzathine penicillin G combination Ampicillin Amoxicillin Amoxicillin + Clavulanic acid Horses Swine Cattle and other ruminants Swine Cattle and other ruminants 22,000–44,000 Units/kg 40,000 IU/kg 44,000-66,000 IU/kg IM IM IM, SC 12-24 24 24 40,000 IU/kg 40,000 Units/kg IM IM 24 24 Swine 40,000 Units/kg IM 24 SC 12 IM, PO IV, IM SC, IM IM, SC 24 24 8-12 12-24 PO, IM, IV IV 6-8 6–8 Broad-spectrum penicillins Cattle and 22 mg/kg for respiratory other ruminants infections 4–10 mg/kg q24h Horses 10-50 mg/kg Swine 6-8 mg/kg Cattle and 10-15 mg/kg other ruminants Horses 15–30 mg/kg Horses 15–25 mg/kg Procaine penicillin G + Benzathine penicillin G Indication: provides antimicrobial activity against gram-positive organisms. Cattle, Buffalo, Horses, Sheep, Goat: Actinomycosis, anthrax, black quarter, calf diphtheria, foot rot, leptospirosis, malignant oedema, pneumonia, navel ill, abscess, mastitis, metritis, strangles, bacterial influenza, bronchitis, castration, pyogenic infections, urinary tract infections. Use in Pregnancy & Lactation: safe for use in pregnant and in lactating animals. Trade name Composition Trade Dose Vial size Company Inj. Bipen-Vet Each vial contains-Procaine 1 ml/10 kg, deep IM, 40 lac vial Square 40 Penicillin- 30,00,000 IU and q24h, 3-5 days. + 10 ml Benzyl Penicillin SodiumWFI 10,00,000 IU. Inj. Pronapen Do Do Do Renata vet 40 Lac Inj. Combipen Do Do Do Acme vet 40 Lac Inj. Pronacillin Do Do Do Techno 40 Lac Inj. Vetopen Do Do Do Opsonin 40 Lac 19 Inj. Procaben Vet Inj. Duplocillin LA Do Do Do Bengal Procaine penicillin 150,000 IU per mL. Benzathine penicillin 150,000 IU per mL. 1 mL/25 kg BW SC/IM (as 12,000 IU/kg) Injection may be repeated at 72 hour intervals depending on clinical judgment given at a different injection site. 100 mL bottle MSD Animal Health Procaine penicillin G + benzathine penicillin G + Streptomycin (Broad-spectrum penicillins) Indications: Fortified procaine penicillin which provides antimicrobial activity against gram-positive organisms and Streptomycin sulphate provides antimicrobial activity against gram negative and acid fast bacteria. Infections caused by microorganisms susceptible to penicillin or, streptomycin like respiratory, uterine & alimentary tract infections, mastitis, osteomyelitis, peritonitis, septicemia, cystitis, joint-ill and secondary bacterial infections in horses, cattle, pigs, foals, calves, sheep & goats. Use in Pregnancy & Lactation: Not safe. Streptomycin crosses the placenta and may cause vestibular, cochlear & renal toxicity. Trade name Composition Trade Dose Vial size Company Inj. Streptopen Per 2.5 gm vial contains 1 ml/ 10 kg BW, 2.5 gm vial + Renata 2.5g Procaine penicillin-15 lac, IM, q24h, 3-5 days. 10 ml WFI Benzyl penicillin-5 lac, Streptomycin-2500 mg Inj. Strepcin-G 2.5g Do Do Do Opsonin Inj. SP-Vet Do Do Do Acme Inj. Strepto-p Do Do Do ACI Inj. Streptocillin Do Do Do Techno Ampicillin Indication: is active against penicillin sensitive gram positive and gram negative bacteria. Indicated in different bacterial diseases of animals e.g. Pneumonia, Foot rot, Enteritis, Salmonellosis, Calf scour, Infected wound, Fever, Colibaciliosis, Metritis, Mastitis, Pyelonephritis, Black quarter, Joint infection, Kidney infection, Haemorrhagic septicemia etc. Use in Pregnancy & Lactation: is safe in pregnancy state and in lactating period in animals. Side Effects: skin rash, pain at the site of injection, diarrhea etc. may occur. Trade name Composition Trade Dose Vial size Company Inj. AmpicinEach vial contains 0.5 ml/10 kg BW, IM/IV, Once 2 gm vial + Square Vet Ampicillin Sodium daily but in severe infection twice 10 ml WFI. BP 2.0 gm daily for 3-5 days. (as 10 mg/kg) Inj. Picilin vet Do Do Do Popular Inj. Bipilin DS Do Do Do Opsonin Inj. Acipilline Do Do Do ACI Amoxicillin Indication: is active against penicillin sensitive gram positive and gram negative bacteria. It is effective against various diseases like – Mastitis, Metritis, Gastroenteritis, Salmonellosis, Calf scour, 20 Bronchopneumonia, Pharyngitis, Umbilical infection, Foot rot, Fever, Campylobacteriosis, Urinary tract infection, Black quarter, Haemorrhagic septicaemia, Joint infection etc. Use in Pregnancy and Lactation: is safe during pregnancy & lactating period. Trade name Composition Trade Dose Pack/vial size Company Injections Inj. Each vial contains 1 ml/ 10 kg bw, IM/SC, once or 1 gm vial + 10 Opsonin Hicomox Amoxicillin twice daily for 3-5 days. ml WFI Sodium 1 gm. (as 10 mg/kg) Inj. MoxacilDo DO Do Square Vet Inj. Acimox Do Do Do ACI Vet Inj. Do Do Do Techno Amoxyvet Inj. Fimox Do Do Do Popular Vet Inj. Moxilin Amoxicillin 1 ml/ 10 kg bw, IM/SC, once 10 ml, 100 ml Acme Vet LA trihydrate BP: 150 q48h for 2-3 days. vial mg/ml (as 15 mg/kg) Inj. Invemox Do Do 100 ml vial ACI 15% LA Inj. Fimox DS Each vial contains 1 ml/ 20 kg bw, IM, once daily 2 gm vial + 10 Popular Vet Amoxicillin for 3-5 days. ml WFI Sodium 2 gm. (as 10 mg/kg) Inj. Aject DS Do Do Do SK+F Vet Bolus Bol. Moxilin Each bolus Livestock: One bolus/125 kg 1 gm bolus Acme vet contains body weight (8 mg/kg) twice Amoxicillin (as daily. Trihydrate) BP 1 Horse: One bolus/25-40 kg gm. body weight thrice daily. Bol. Amoxicillin: 500 1 bolus / 50 kg B.W. orally 500 mg bolus Renata Renamox mg/bolus. Once/Twice daily for 5 - 7 days. Bol. AlmolinDo Do Do Al-madina Vet Bol. Do Do Do Navana Navamox vet Amoxicillin + Clavulanic acid Indications: is highly effective against penicillin sensitive gram positive and gram negative bacteria. It is effective against various disease like mastitis, metritis, gastroenteritis, salmonellosis, calf scour, pharyngitis, bronchopneumonia, umbilical infection, foot root, fever, campilobacilosis, urinary tract infections, black quarter, haemorrhagic septicemia, joint infection etc. Use in pregnancy and lactation: The safety of administration of Amoxicillin and clavulanic acid to pregnant or breeding animal is unknown. Trade name Composition Trade dose vial size Company Inj. Augment Each vial contains, 1 mL / 28 Kg body weight, 1.2 gm vial + SK+F Vet 1.2g Amoxicillin sodium-1 by IM/SC, once daily for 310 mL WFI 5 days. 21 g & Clavulanic Acid 200 mg Inj. Amoclav 1.2g Inj. Moxaclav 1.2g Inj. Augment Vet 2.4g Do (as 7 mg/ Kg) Or 1 ml/10 kg BW, IM/SC, once daily for 3-5 days. (as 12 mg/kg) Do Do Techno Do Do Do Square Each pack contains, Amoxicillin sodium 2 g & Clavulanic Acid 400 mg/ vial Do 2.4 gm vial + 10 mL WFI SK+F Cephalosporins Mode of action: Cephalosporins have a mechanism of action identical to that of the penicillin. Like the penicillins, cephalosporins have a beta-Lactams ring structure that interferes with synthesis of the bacterial cell wall and so are bactericidal. Drug Species Dose Route Interval (hr) First-generation Cephalosporins Cefazolin sodium Horses 10–20 mg/kg IV 6-8 h Foals 15–20 mg/kg IV 8–12 h Cephalexin Horses 22–33 mg/kg PO 6h Third generation Cephalosporins Cefotaxime Foals 20–30 mg/kg IV or IM 6-8 h Cefpodoxime proxetil Ceftriaxone Foals 10 mg/kg PO 6–12 h Horse 25-50 mg/kg IV, IM 12-24 h Cattle 1.1--2.2 mg/kg IM 24 h Sheep/goats 1.1--2.2 mg/kg IM 24 h Horse 2.2 -- 4.4 mg/kg IV or IM 12–24 h Swine 3 -- 5 mg/kg IM 24 h IV 8h Ceftiofur Fourth-generation Cephalosporins Cefepime Horse 11 mg/kg Ceftriaxone Indication: Ceftriaxone is indicated for the treatment of wide variety of infections caused by sensitive gram-positive, gram-negative and anaerobic organisms. This drug has high potential application in septicemia, serious bone and joint infections, some lower respiratory tract infections, intra-abdominal infections and some soft tissue infections. • Respiratory tract infections (Broncho-Pneumonia, Pneumonia) • Uro-genital tract infections (Metritis, Nephritis, Pyometra, Cystitis) -Visceral infections and peritonitis • Gastro-intestinal tract infections (Calf scours, Enteritis, Diarrhoea Bacterial septicemia • Mastitis • Meningitis • Skin & soft tissue infections 22 • Pre-operative prophylaxis • Post-operative bacterial infections Use in Pregnancy & lactation: Ceftriaxone can be used safely during pregnancy. Low concentration of Ceftriaxone is excreted through milk, caution should be exercised when Ceftriaxone is administered to a lactating animal. However, risk & necessity should be considered during administration in pregnancy. Trade name Composition Trade dose vial size Company IM preparation Each vial Cattle/Buffalo/Calves/Zoo animal: 1 500 mg vial contains ml/ 28 kg body weight deep IM daily + 2 ml 1% Ceftriaxone for 3-5 days. lidocaine 500 mg (as 10 mg/kg) Goat/Sheep: 1 ml/14 kg body weight Inj. ACICEF-3 ACI deep IM twice daily for 3-5 days. (Vet) (as 20 mg/kg) Horse: 1 ml/ 11 kg body weight deep IM twice daily for 3-5 days (as 25 mg/kg) Inj. Eracef vet Inj. Trizon Vet Do Do Inj. TrijectVet Do Inj. Renacef vet Inj. Eracef vet Inj. ACICEF-3 (Vet) Inj. Trizon Vet Inj. Bovixon Vet Inj. TrijectVet 1 gm vial + 3.5 ml 1% lidocaine Do Do Do Do Cattle/Buffalo/Calves/Zoo animal: 1 ml/ 23 kg body weight deep IM daily for 3-5 days. (as 10 mg/kg) Goat/Sheep: 1 ml/11 kg body weight deep IM twice daily for 3-5 days. (as 20 mg/kg) Cattle/Buffalo/Calves/Zoo animal: 1 ml/ 28 kg body weight deep IM daily for 3-5 days. (as 10 mg/kg) Goat/Sheep: 1 ml/14 kg body weight deep IM twice daily for 3-5 days. (as 20 mg/kg) Horse: 1 ml/ 11 kg body weight deep IM twice daily for 3-5 days (as 25 mg/kg) Do Do Do Do Popular Do Do Do Do Do Do Acme Do Cattle/Buffalo/Calves/Zoo animal: 1 ml/ 23 kg body weight deep IM daily for 3-5 days. (as 10 mg/kg) Goat/Sheep: 1 ml/11 kg body weight deep IM twice daily for 3-5 days. (as 20 mg/kg) 1 gm vial + 4 ml 1% lidocaine Each vial contains Ceftriaxone 1 gm. Do Do Popular Acme SK+F Do Renata ACI Incepta SK+F 23 Inj. Renacef vet Inj. Eracef vet Inj. ACICEF-3 (Vet) Inj. Trizon Vet Inj. Bovixon Vet Each vial contains Ceftriaxone 2 gm. 2 gm vial + 7 ml 1% lidocaine Do Do Cattle/Buffalo/Calves/Zoo animal: 1 ml/ 28 kg body weight deep IM daily for 3-5 days. (as 10 mg/kg) Goat/Sheep: 1 ml/14 kg body weight deep IM twice daily for 3-5 days. (as 20 mg/kg) Horse: 1 ml/ 11 kg body weight deep IM twice daily for 3-5 days (as 25 mg/kg) Do Do Do Do Popular Do Do Do Do Do Do Acme Do Cattle/Buffalo/Calves/Zoo animal: 1 ml/ 23 kg body weight deep IM daily for 3-5 days. (as 10 mg/kg) Goat/Sheep: 1 ml/11 kg body weight deep IM twice daily for 3-5 days. (as 20 mg/kg) IV preparation Large animals: 1 ml/ 10 kg body weight IV daily for 3-5 days. (as 10 mg/kg) Sheep/Goat: 1 ml/ 5 kg body weight IV twice daily for 3-5 days. Do 2 gm vial + 8 ml 1% lidocaine Inj. TrijectVet Inj. TrijectVet Inj. Trizon Vet Inj. CeftronVet Inj. Trizon Vet Inj. TrijectVet Inj. CeftronVet Inj. ACICEF-3 (Vet) Inj. Trizon Vet Inj. TrijectVet Each vial contains Ceftriaxone 500 mg Do Renata ACI Incepta SK+F 500 mg vial + 5 ml WFI Do SK+F Acme Each vial contains Ceftriaxone 1 gm Do Do 1 gm vial + 10 ml WFI Do Do DO DO DO Each vial contains Ceftriaxone 2 gm. DO DO 2 gm vial + 20 ml WFI DO DO Do Do Do DO DO DO Square Acme SK+F Square ACI Acme SK+F 24 Ceftiofur Indications: is a broad spectrum bactericidal antibiotic which is effective against both gram positive and gram negative bacteria including ß-lactamase enzyme producing strains. This drug is indicated for the treatment of bovine respiratory diseases (shipping fever, pneumonia) associated with Mannheimia haemolytica, Pasteurella multocida & Histophilus somni, acute bovine interdigital necrobacillosis (foot rot, pododermatitis) associated with Fusobacterium necrophorum & Bacteroides melaninogenicus and Genital tract infections (endometritis, postpuerperial metritis, toxic puerperal metritis, pyometra) associated with E.coli, Fusobacterium necrophorum, Arcanobacterium pyogenes. Use in pregnant and lactating animal: The effects of Ceftiofur on the reproductive performance, pregnancy and lactation have not been determined yet. Trade name Composition Trade dose Vial size Company Inj. Tifur Vet Each vial contains Cattle/Sheep/Goat: 1 ml/25 kg 0.5 gm vial Acme Ceftiofur Sodium BW (as 2 mg/kg) Or 1 ml/ 23-45 + 10 ml sterile powder kg, IM/SC once daily for 3-5 WFI 0.5 g days. Horse: 1 ml/ 12-23 kg by IM once daily & continued for 2 days after disappearing of clinical signs. (as 2.2-4.4 mg/kg) Inj. Dedicef DO DO DO SK+F vet Inj. Ceftiren DO DO DO Renata Vet Inj. Xfur Do Do Do Techno Inj. Tifur Vet Each vial contains DO 1 gm vial + Acme Ceftiofur Sodium 20 ml WFI sterile powder 1g Inj. Dedicef DO DO DO SK+F vet Inj. PaXXcell DO DO DO ACI Inj. Ceftiren DO DO DO Renata Vet Inj. Xfur Do Do Do Techno Fluoroquinolones Mode of Action: The quinolones inhibit bacterial enzyme Topoisomerases, including topoisomerase II and topoisomerase IV, otherwise known as DNA-gyrase. Topoisomerases support supercoiling and subsequent uncoiling of DNA so that the DNA can twist into the chromosomal domains that conform to the RNA core. (bactericidal) Classification: 1. First generation (original quinolones): Nalidixic acid, Oxolinic acid, Flumexine. 2. Second generation (fluroquinolones): Ciprofloxacin, Enrofloxacin, Difloxacin, Norfloxacin, Donofloxacin, Ofloxacin, Pefloxacin 3. Third generation: Levofloxacin, Sparfloxacin 4. Forth generation: Marbofloxacin, Moxifloxacin Drug Species Dose Route Interval (hr) Horse 5–7.5 mg/kg PO 24 h 25 Cattle Cattle 2.5–5 mg/kg for 3–5 days 7.5–12.5 mg/kg once. 5 mg/kg 10 mg/kg 2 mg/kg BW upto 5 days Pig 2 mg/kg BW upto 5 days Rumunant Cattle 5 mg/kg bw 6 mg/kg. Enrofloxacin Camelids Marbofloxacin Ciprofloxacin Danofloxacin SC SC SC PO PO/ Parenteral PO/ Parenteral IM, IV SC 24 h 24 h 24 h 24 h 24 h 24 h q48h ✓ A synergistic effect has been demonstrated in vitro between quinolones and beta-lactam antimicrobials, aminoglycosides, clindamycin, and metronidazole. Enrofloxacin Indication: It (Enrotril Max) is most effective against following disease of cattle buffalo, sheep, goat for Mastities, Diarrhoea , Respiratory tract infection and Pneumonia, Skin & Soft tissue infections, Mycoplasmal Mastities, Colibacillosis, Anaplasmosis and Foot rot. Also most Effective to prevent Secondary bacterial Infection during Viral Infection. Use in pregnant and lactating animal: It (Enrotril Max) is Pregnency Safe and do not effect on Milk Production. Trade name Composition Trade dose Vial size Company Inj: Enrotril Each mL contain 1 ml/13 kg BW once, 20 ml vial Axon Max (L.A) Enrofloxacin I.P- 100 mg, IM/SC, if need repeat Animal Benzyl alcohol I.P -20 mg, after 72 h. Health Bytyl alcohol -50 mg, Arginin-20 mg (as 7.5 mg/kg) Marbofloxacin Indication: belongs to 3rd generation Fluoroquinolone with broad spectrum bactericidal antimicrobial activity towards gram positive, gram negative bacteria and mycoplasma. Indicated for Acute mastitis, Diarrhoea and gastro-enteritis , Severe respiratory infections , Neonatal gastro-enteritis caused by Escherichia coli. Use in pregnancy and lactation: may be used safely during pregnancy and lactation. Trade name Composition Trade dose Vial size Company Inj. Marbo Vet Each mL contains Treatment of Respiratory 10 mL, SK+F Marbofloxacin BP Infections-30 mL, 100 mg. Single Dose Treatment: 4 100 mL vial mL/50 kg body weight (8 mg/kg body weight) through IM route. Multiple Doses Treatment: 1 mL/50 kg body weight through IM/SC route for 3-5 days. (as 2 mg/kg BW) Treatment of Acute Mastitis: 1 mL/50 kg body weight (2 mg/kg body weight) by IM/SC route for 3 days. 26 Inj Marbores 10% Inj. Marboflox Inj. Arbocin Vet Bol. Marbo Vet Bol. Marboflox Bol. Arbocin Vet Bol. Marquin Vet Bol. Marvo DS Vet Bol. Arbocin Vet DS DO The first injection can also be carried out by IV administration. DO 20 ml ACI 10 ml DO 50 mg bolus Bridge Acme SK+F DO DO DO DO The recommended dose is 1 mg/kg/day for 3 consecutive days Calves: 1 bolus/ 50 kg body weight for 3 consecutive days. DO DO DO DO Bridge Acme DO DO DO Navana Marbofloxacin BP 100 mg/bolus The recommended dose is 1 mg/kg/day for 3 consecutive days Calves: 1 bolus/ 100 kg body weight for 3 consecutive days. DO 100 mg bolus SK+F DO Acme DO DO Marbofloxacin BP 50 mg/bolus DO Ciprofloxacin Indication: is effective against several diseases as Respiratory Tract infections, Enterotoxaemia, Skin Bone & Ear infections, Anthrax, Swine dysentery, Urinary Tract Infection, Mastitis, Foot Rot, Metritis and GI infection or Enteritis caused by gram-possitive & gram-negative bacteria. Moreover, the drug may acts against other diseases caused by bacteria; eg: Klebsiella, Shigella, Yersinia, Aromonas, Proteus, Pseudomonas, Neisseria, Campylobactor etc. Pregnancy and Lactation: Intravenous doses of ciprofloxacin of up to 20 mg per kg of body weight (mg/kg) in pregnant rats and mice have not shown evidence of maternal toxicity, embryotoxicity, or teratogenic effects. Side Effects: Central nervous system (CNS) toxicity; gastrointestinal reactions; hematuria; hepatotoxicity; hypersensitivity reactions; Stevens-Johnson Syndrome (blistering, itching, loosening, peeling, or redness of skin; diarrhea). Trade name Composition Trade dose Pack size Company Injection Inj. Ciprocin-Vet Each ml injection 1 ml/10 kg body weight, 10 ml, Square contains Ciprofloxacin IM/IV, daily for 3-5 days 50 ml BP 50 mg. (as 5 mg/kg b.wt.) Vial. Inj. Beuflox Vet DO DO DO Incepta Inj. Cipro-A Vet DO DO 30 ml, Acme 100 ml Inj. Civox Vet DO DO DO Popular Inj. Ciproflox DO DO DO SK+F Inj. Ciprosol DO DO DO TECHNO Inj. Acivet Cipro DO DO DO ACI 27 Bol. Civox vet Bol. Cipro-A Vet Bol. Ciprocin vet Bol. Beuflox vet Bol. Proxacin Each bolus contains Ciprofloxacin hydrochloride BP 1 gm DO DO DO Do Bolus Cattle: 1-2 bolus daily for 35 days DO DO DO 1 bolus/ 75-150 kg body weight or 6.7-13.4 mg/ kg body weight twice daily for 3-5 days. 1 gm bolus Popular DO DO DO 1 gm bolus Acme Square Incepta Bridge Danofloxacin Indications : is indicated for the treatment of respiratory disease caused by Pasteurella haemolytica and P.multocida and the treatment of enteric infections caused by Escherichia coli and Salmonella spp. in cattle. Use in pregnancy & lactation: The effects of Danofloxacin on reproductive performance and on pregnancy have not been assessed. Trade name Composition Trade dose Vial size Company Inj. DFN Vet Each mL contains 1 mL/20 kg body weight (1.25 10 ml SK+F Danofloxacin Mesylate mg/kg body weight) for 3-5 INN equivalent to days through IM/IV/SC route. Danofloxacin 25 mg. Tetracyclines Mechanism of action: The Tetracycline are primarily bacteriostatic, inhibit protein synthesis by binding to 30s ribosome's in susceptible organisms. Subsequent to such binding, attachment of aminoacyl-t- RNA to the mRNA ribosome complex is interfered. As a result the peptide chain fails to grow. Drug Species Dose Route Interval (hr) Cattle, Sheep, 10-22 mg/kg BW IM, IV, PO 12--24 h. Goat Oxytetracycline Horse, foal 10-20 mg/kg BW IV , PO 12-24 h Pig 6–11 mg/kg IV, IM 6h 10–20 mg/kg PO 6h Chlortetracycline Cattle, 6–10 mg/kg IV, IM 24 h Swine 10–20 mg/kg PO 24 h Doxycycline Horse 10 mg/kg, for 10-14 days PO 12 h Oxytetracycline Indication: For the treatment and prevention of different types of bacterial diseases of cattle, buffalo, sheep, goat, deer, rabbit and poultry. Cattle, Buffaloes, Sheep, Goat & Deer: For the treatment of actinobacillosis, bacterial enteritis, bacterial pneumonia, bovine respiratory disease complex, diphtheria, keratoconjunctivitis (pink eye), leptospirosis, metritis, anaplasmosis, foot-rot, black leg, navel ill, joint ill, heart water, dermatophilosis, enzootic abortion (bedsoniasis), wound infections, mycoplasmosis, Aid in the control or prevention of shipping fever, pneumonia, post operative and post parturient infections. Rabbit: For the prevention and treatment of conditions / diseases susceptible to Oxytetracycline including infections due to Pasteurella multocida, Bordetella brochoseptica, Escherichia coli and Salmonella spp etc. 28 Use in Pregnancy and Lactation: should not be used during pregnancy because of the risk of hepatotoxicity in the mother as well as the effects on the developing fetus. Use in pregnancy and lactation may result in impaired bone growth and reduce milk production. Drug interactions: should not be used concurrently with penicillins, cephalosporins, quinolones and is incompatible with the preparations containing polyvalent cations (Ca ++, Mg++, Fe++). Trade name Composition Trade dose Pack size Company Injections Inj. Otetra-Vet Each ml contains 1 ml/ 5 kg BW, IM/IV/SC. for 10 ml vial Square Oxytetracycline 3-5 days. BP 50 mg (as 10 mg/kg) (If given IV, drug should be mixed with equal amount of Distilled water or NS) Inj. Renamycin-50 DO DO Do RENATA Inj. Chemycin- 50 DO DO 10 ml Chemist 100 ml Inj. TechnomycinEach ml contains DO 10 ml TECHNO 50 Oxytetracycline BP 50 mg & Lignocaine HCI- 20 mg (2%) Inj. Renamycin-100 Each ml contains 1 ml/ 10 kg BW, IM/IV. for 3-5 10 ml, Renata Oxytetracycline days. 100 ml BP 100 mg (as 10 mg/kg) vial (If given IV, drug should be mixed with equal amount D.water or NS) Inj. Oxyvet-100 DO DO DO Globe Inj. Vetomycin DO DO DO OPSONIN Inj. TechnomycinDO DO DO TECHNO 100 Inj. Tetravet-100 DO DO DO ACME Inj. Chemycin- 100 Each ml contains DO Do Chemist Oxytetracycline BP 100 mg & Lignocaine HCI- 20 mg (2%) Inj. Otetra-Vet LA Each ml contains Cattle, Buffaloes, Sheep, 10 ml vial Square Oxytetracycline Goat & Deer: Single dose BP 200 mg treatment of 1 ml/ 10 kg BW by IM route. (as 20 mg per kg) Poultry & Rabbit: Single dose treatment of 0.25 ml/ kg BW by SC route. (as 50 mg/ kg). Severe infections may require re-treatment at 3 to 5 days following initial injection. Inj. Chemycin-LA DO DO DO Chemist Inj. Renamycin LA DO DO DO Renata 29 Inj. TechnomycinLA Inj. Tetravet LA Inj. Eskamycin LA Bol. Chemycin Bol. Vetomycin Bol. OTC Vet Bol. Technomycin Bol. Tetravet Bol. Eskamycin Bol. Oxysentin Tab. Renamycin Af (vet) Tablet. Otetra-Vet Tab. Bactitab Tab. Eskamycin DO DO DO Techno DO DO DO DO DO DO Acme SK+F Bolus 1-2 bolus/100 kg BW, for 5-7 days. 500 mg bolus CHEMIST DO DO DO DO DO DO 500 mg tablet DO DO DO OPSONIN POPULAR TECHNO ACME SK+F NOVARTIS RENATA Each bolus contains Oxytetracycline BP 500 mg DO DO DO DO DO DO Oxytetracycline: 500 mg/ Tablet DO DO DO DO DO DO DO DO DO See below picture DO DO DO SQUARE ACI SK+F Aminoglycosides Mode of action: Aminoglycosides have bactericidal activity. The main site of action of aminoglycosides is the bacterial ribosomes through which they interfere with protein synthesis. Aminoglycosides bind to the 30S ribosome causing misreading of mRNA so interfere with the process of amino acids polymerization and result in synthesis of non-functional or defective protein. Defective protein fails to function correctly. Drug Species Dose Route Interval (hr) Cattle 2-5 mg/kg IM 12-24 h Horse 2–4 mg/kg IV, IM, SC 12 h Gentamicin 6.6–8.8 mg/kg IV, IM, SC 24 h Swine 1.1–2.2 mg/kg, as medicated PO 24 h water for 3 days 30 Amikacin Horses Calves Streptomycin Swine Neomycin Apramycin Horse Cattle Horse Swine Cattle, swine 10 mg/kg 22–33 mg/kg, as medicated water 22-33 mg/kg as medicated water 11 mg/kg 10–20 mg/kg 5–15 mg/kg 7–12 mg/kg 20–40 mg/kg IV PO oral IM, SC PO PO PO PO 24 h q 24 h for up to 5 days 24 h for up to 4 days 12 h q12h q24h q12h 24h Gentamicin Indication: Broad spectrum antibiotic widely used for the treatment of urinary and respiratory tract infections. For the treatment of severe infections caused by susceptible gram positive and gram negative bacteria including species of pseudomonas, proteus, many coliform bacilli and mycoplasma as well. Effective in enteric disease of neonates like scour and salmonellosis. Side Effect: Hypocalcaemia, neuromuscular paralysis, hypotension, nephrotoxicity and ototoxicity have been reported with high and prolonged medication. Contraindication: is contraindicated to patients hypersensitive to Gentamicin. It is contraindicated in pregnancy and myasthenia gravis. Trade name Composition Trade Dose Vial size Company Inj. Genacyn-Vet Each ml contains IV or IM Injection 10 ml, Sqaure 10 Gentamicin Sulphate 1 ml per 25 kg body weight 100 ml BP 100 mg. This dose preferably to be Vial given twice for 1st day and afterwards once daily for 3-5 days. (as 4 mg/kg) Inj. Acigent-10 DO DO DO ACI Inj. Genta-10 DO DO DO ACME Inj. Gentabac DO DO DO POPULAR vet Inj. Gentaren DO DO DO RENATA Inj. Intamycin DO DO DO Incepta vet Inj. Reganta 10% DO DO DO Bengal Neomycin Description: Neomycin Sulfate is a broad-spectrum antibiotic of the aminoglycoside class. It is active against gram-positive and gram-negative bacteria like Escherichia coli, Salmonella, Campylobacter, Pasteurella, Staphylococci and Listeria spp. Indication: Calf Diarrhea, Calf Scour. Use in pregnancy, lactation: Neomycin should not be used during pregnancy, lactation. Trade name Composition Trade dose Pack size Company Pulv. Neoxel Each gm powder Cattle: 1 gm / 50 kg body 10 gm SK+F vet contains Neomycin weight (10 mg / kg body 100 gm Sulphate USP 500 weight) for 3-5 days. mg. Pulv. N-Cin Vet Do Do Do ACI 50 31 Pulv. Neovet Pulv. Nimocin Vet Pulv. Remeneo Vet Each gm powder contains Neomycin Sulphate USP 700 mg. Do Calf, goat, sheep & swine: 1 g/70 kg body weight (10 mg/kg) for 3-5 days. 100 gm Techno Do Acme Do Do 10 g 100 g sachet. Do Bengal Apramycin Indication: It is indicated for the treatment of bacterial enteritis, colibacillosis, salmonellosis, respiratory infections etc. Use in pregnancy & lactation Cow: Laboratories studies have not produced any evidence of teratogenic, fetotoxic or meternotoxic effects. In Sows: The use is not recommended in pregnant or lactating sows. Trade Name Composition Trade dose vial size Company Inj. Prycin Vet Each ml contains For IM/SC injection only. 10 ml Acme Apramycin Sulfate 1 ml/ 10 kg body weight for 5 30 ml BP 200 mg. days. Sulfonamides Mode of action: Sulfonamides competitively inhibit dihydropteroate synthase, the enzyme which catalyzes the incorporation of PABA into dihydrofolic acid. Folic acid is required for purine and DNA synthesis and thus bacterial growth is inhibited. Sulfonamides are broad spectrum (including protozoa) and bacteriostatic. Use in Pregnancy: Safety has not been clearly established in pregnant animals. Reports of teratogenicity (cleft palate) have been reported. Should not be used on pregnant animal. Drug Species Dose Route Interval (hr) Sulfadimidine Cattle 100-200 mg/kg, IV 24 h (initial dose, half for subsequent doses) Potentiated Sulfonamides Sulfadiazine + Cattle 25–48 mg/kg IM, IV 24h Trimethoprim Horse 15–30 mg/kg PO, IV 12h Swine 48 mg/kg IM 24h Sulfamethoxazole + Cattle 25–48 mg/kg IM, IV 24h TrimethoprimHorse 15–30 mg/kg PO, IV 12h Swine 48 mg/kg IM 24h Sulphadimidine Indication: effective against certain gram positive and gram negative bacteria and protozoa and certain rickettsial organism. Indicated for Bacterial pneumonia, footrot, bacterial enteritis, calf scour, colibacillosis, metritis, mastitis, joint ill, strangles, actinobacillosis, toxoplasmosis, pasteurellosis, streptococcal infection of horse and dog, haemorrhagic septicaemia and secondary bacterial infection due to influenza, contagious coryza, foot & mouth disease (FMD), distemper. Precaution: In recommended dose, sulpha drugs are relatively safe and generally have no side effects. But prolonged treatment has been known to cause agranulocytosis, haemolytic anaemia and avitaminosis K. Sulphonamides occasionally cause crystalluria, particularly when urine pH is low. So adequate water intake should be ensured during treatment. 32 Side Effect: Includes allergic rashes, diarrhoea, dehydration, debility, loss of appetite, hypogalactia, digestive disturbances in ruminants and in other species depression, nausea, vomiting, crystalluria, haemolytic anaemia. Trade Name Composition Trade dose Pack Company size Injections Inj. Diadin Each ml solution IV, IM, SC 30 ml, RENATA contains Initial dose (1st dose)100 ml sulphadimidine 15-30 ml/ 50 kg body wt. vial nd sodium BP 333.3 Maintenance dose (2 day mg. onward)½ of initial dose daily for 3 days. Inj. Dimidin DO DO DO TECHNO Inj. Dimi-Vet DO DO DO SQUARE Inj. Fadimin DO DO DO SK+F Inj. Salidone DO DO DO ACI Inj. Sulfasol-Vet DO DO DO ACME Inj. Suldimin Vet DO DO DO EON Bolus Bol. Diadin Sulphadimidine: In cattle, buffaloe, sheep, goats 5 gm RENATA 5 gm/bolus and other large animals: 2 bolus/ bolus 50 kg BW are recommended as an initial dose followed by half of the doses daily. (as 200 mg/ kg) Bolus may be given whole or crushed in the form of powder. Bol. Sulfasol-Vet DO DO DO ACME Sulpadiazine + Sulphadimidine + Sulphapyridine (additive in action) Indications: is a combination of three potent sulphonamides effective against systemic and enteric diseases caused by gram positive and gram-negative organisms and protozoa. It is indicated for the treatment of systemic and intestinal infections caused by Sulphonamide sensitive organisms such as diarrhoea, dysentry, pneumonia, diphtheria, hemorrhagic septicemia, navel ill, urinary infections, infectious arthritis & to prevent secondary bacterial infections in viral diseases. Warnings: In animals with kidney problem, drug should be administered cautiously. During treatment period sufficient drinking water should be provided to the sick animal. Trade name Composition Trade Dose Pack Company size Bol. Sulpha 3 Each bolus contains: Starting dose (1st day): 10×2 RENATA Sulphadiazine-1.666 gm 1 bolus for 35 Kg body bolus Sulphadimidine-1.666 gm weight. Sulphapyridine-1.666 gm Folow up dose (from 2nd day): ½ bolus for 35 Kg body weight. Treatment should be continued 3-4 days. If necessary treatment may continue up to 7 days. Bol. Triplex-Vet Do Do Do SQUARE 33 Bol. Bactrin Bol. Trisulpha Bol. Sulphadin vet Bol. Sulfon Bol. 3 Sulfa Bol. Sulfamide3 Bol. Sulfadin Do Do Do Do Do Do Do Do Do ACI NOVARTIS ACME Do Do Do Do Do Do Do Do Do OPSONIN POPULAR SK+F Do Do Do Acme Sulphadiazine + Trimethoprim (Potentiation in action) Indication: is used for the prevention and treatment of different infections caused by different grampositive & gram- negative bacteria in livestock. It is also used in dermatitis and wound infections. This drug is also used for the treatment of Hemorrhagic septicepmia and Diphtheria of calf, Pasteurellosis, Actinomycosis, Actinobacillosis, Coccidiosis, Mastitis, Metritis, Necrotic Rhinitis, Keratitis infection, Polyarthritis, oral necrobacillosis, Foot rot, Pneumonia, Salmonellosis, Toxoplasmosis, Bronchitis, Bronchopneumonia etc. Precaution: In case of hypersensitivity, adequate fluid intake should be ensured during therapy. Trade name Composition Trade Dose Pack size Company Bol. Remetrim Each bolus contain For oral administration: Each box Bengal Vet Sulphadiazine : Smashed can be administered contains 4 X 6 1000 mg via feed or drinking water Bolus in Trimethoprim: Cattle, Horse, Sheep & Goat: Blister Strips 200 mg 1 Bolus per 40 kg body weight daily or 30 mg per kg body weight daily (use Bolus twice a day by giving half of the dose). Intrauterine: Smashed Bolus can be used via mild hot water by a catheter. Cow, Buffalo and Horse: 2-4 Bolus Sheep & Goat: 1-2 Bolus. Bol. Renatrim Do Do Do RENATA Bol. Sulphatrim Do Do Do TECHNO Sulphamethoxazole + Trimethoprim (Potentiation in action) Indication: It is used for infections of urinary, respiratory and genital tracts, skin and wound infections and other bacterial infections. It is used for the treatment of actinobacillosis, actinomycosis, coccidiosis, mastitis, canine erlichiasis, oral necrobacillosis, infectious foot rot, necrotic rhinitis, metritis, infectious keratitis, infectious polyarthritis, post abortion, pneumonia, salmonellosis, toxoplasmosis, bronchitis, diarrhoea, bronchopneumonia, etc. Use in Pregnancy and Lactation: Risk of haemolysis & kernicterus in calves treated with this drug. Contraindication: should not be administered to ruminants with functioning rumen to avoid possible disturbance of the ruminal flora. It is also contraindicated in animal with severe hepatic or renal insufficiency, blood disorders. Precaution: For animal use only. Adequate fluid intake should be ensured during therapy. 34 Trade name Bol. CotrimVet Composition Each bolus contain Sulfamethoxazole: 1000 mg Trimethoprim: 200 mg Pack size 5 x 4’s blisters in a box Company SQUARE Do Trade Dose Cattle & Horse: 1 bolus/40-kg body weight oe 30 mg/kg body weight daily. Calf, Sheep, Goats: 30 mg/kg body weight daily for 5 to 7 days. Cotrim-Vet® can be administered oraly by mixing with foods or drinking water. Do Bol. Politrim Vet Bol. Cidacot Bol. Remetrim Vet Do ACME Do Do Do Do Do Do OPSONIN Bengal Macrolide Antibiotics Mechanism of action: The macrolide antibiotics inhibit protein synthesis by binding reversibly to 50s ribosomal subunits of sensitive bacteria and this binding interferes protein synthesis. (bacteriostatic) Drug Species Dose Route Interval (hr) Cattle 4–8 mg/kg IM q12–24h Sheep 2.2 mg/kg IM 24h Erythromycin Horse 25 mg/kg PO 12h (also GI Prokinetic) 0.1 mg/kg/ h IV Tilmicosin Tylosin Swine Cattle, Sheep Cattle Sheep, goat 2.2–6.6 mg/kg 10 mg/kg 5–10 mg/kg 10 mg/kg IM SC IM, IV IM 24h 72h 24h (Not to exceed 5 d) Horse Pigs 10 mg/kg 8.8–12.5 mg/kg IM IM 12h 12h (Not to exceed 3 d) Tylosin Indications: is indicated for the treatment of infectious disease caused mainly by gram positive bacteria and mycoplasma. Livestock: In beef cattle and non-lactating dairy cattle, it is indicated for use in the treatment of bovine respiratory complex (shipping fever, pneumonia) usually associated with Pasteurella multocida and Actinomyces pyogenes; foot rot (necrotic pododermatitis) and calf diphtheria caused by Fusobacterium necrophorum and metritis caused by Actinomyces pyogenes. Swine: it is indicated for use in the treatment of swine arthritis caused by Mycoplasma hyosynoviae; swine pneumonia caused by Pasteurella spp; swine erysipelas caused by Erysipelothrix rhusiopathiae; swine dysentery associated with Treponema hyodysenteriae. Use in Pregnancy and Lactation: Safe. (https://www.ema.europa.eu/en/documents/mrl-report/tylosin-summary-report-3-committeeveterinary-medicinal-products_en.pdf) Trade name Composition Trade Dose Pack size Company 35 Inj. Tylovet Each ml contains Tylosin BP 200 mg. 1 ml/ 20 kg BW, (or 1 10 ml vial ACME ml/10-20 kg) IM, q24h, for 3-5 days. (as 10 mg/kg) Inj. Tylochem Do Do Do CHEMIST Inj. Tylosef Do Do Do SK+F Inj. Each ml contains, For intramuscular 50 ml, ACI TYLO p.c Gold Tylosin tartrate- 57.5 mg injection once a day. 100 ml Thiamphenicol- 200 mg Cattle: 3-6 ml/ 100 kg Prednisolone acetate- 5 body weight. mg Calf, sheep and goat : 1 ml / 10 kg body weight Tylo-PC gold is indicated in cattle, calf, sheep and goat for the treatment and control of a wide range of common systemic respiratory, gastrointestinal, septicemia, MMA syndrome and local infections caused by, or associated with, organisms sensitive to Tylosin and Thiamphenicol. Cattle: Pneumonia, bronchitis, pasteurellosis, metritis, foot-rot, mastitis, and 36abelled36id. Calf, sheep and goat: Pneumonia, pasteurellosis, mastitis-metritis-agalctia (MMA) syndrome, 36abelled36id, bacterial diarrhea and enteritis. Caution: ✓ Do not use in pregnant animals and liver disorder animal. ✓ Withdrawal period: meat – 21 days. ✓ Do not administer 10 consecutive days. Tilmicosin Pharmacology: Tilmicosin is a semi-synthetic antibiotic of the macrolide group, and is believed to affect protein synthesis of bacteria. It has bacteriostatic action but at high concentrations it may be bactericidal. Tilmicosin antibacterial activity is predominantly against Gram-positive microorganism with activity against certain gram-negative ones and Mycoplasma of a bovine, porcine, ovine and avian origin. Indication: Calves: For the treatment and prevention of bovine respiratory disease, associated with Mannheimia haemolytica, Pasteurella multocida, Mycoplasma bovis, M. dispar, Actinobacillus spp. Actinomyces spp. Precautions: Inappropriate use of the product may increase the prevalence of bacteria resistant to Tilmicosin and may decrease the effectiveness of treatment with Tilmicosin-related substances. Medicated drinking water should be prepared fresh every 24 hours. Use in Pregnancy and Lactation: Safe use in pregnant animals or animals to be used for breeding purposes has not been demonstrated. Trade name Composition Trade Dose Pack size Company Sol. Tilmibac Each ml solution Calves/Sheep/Goat: 1 ml per 20 100 ml, Popular Vet contains kg body weight or, 12.5 mg/kg 250 ml, Tilmicosin Phosphate body weight and given 500 ml 250 mg twice daily for 3-5 consecutive days Sol. Tilmisin Do Do Do Renata vet Soln. Acmetil Do Do Do Acme vet Sol. Tilcosin Do Do Do Square vet Sol. Tilvet Do Do Do Al-Madina Sol. Avitil vet Do Do Do incepta 36 Soln. Tilmac Do Do Soln. Qtill-S vet Do Do 100 ml 500 ml 20 mL, 100 mL, 500 mL 1 L Bottle Bridge SK+F Nitroimidazoles Metronidazole Mechanism of action: Metronidazole is taken up by anaerobic bacteria and protozoa and reduced to a cytotoxic metabolite, which disrupts DNA. It is bactericidal against most obligate anaerobes and is active against protozoa, including Giardia and Trichomonas spp. Species Dose Route Interval (hr) Horse 10–25 mg/kg PO, IV 6h Ruminant 40 mg/kg PO 24 h The use of nitroimidazoles in food-producing animals is strictly prohibited by the US FDA. Cattle receiving metronidazole should never enter the food chain. Indications: Metritis, pyometra, retained placenta, vaginitis, gingivitis, calf scour, balantidiasis, trichomoniasis, giardiasis etc. Use in Pregnancy and lactation: It should be avoided in pregnant animals, especially in the first trimester and it should not be used in lactating animals. Side effect: Usually salivation, vomiting, decreased appetite, gastrointestinal upset etc may occur. Trade name Composition Trade Dose Pack size Company Inj. Metro IV Each ml solution contains, Metronidazole 5 mg/ ml Inj. Flagyl IV Inj. Filmet IV DO DO Bol. AmodisVet Each bolus contains, Metronidazole BP: 2000 mg Bol. Dirovet Bol. Remenid Bol. Metrovet Bol. Metonid Bol. Renamet Bol. Zonabac DO DO DO DO DO DO Injection 2 ml/ kg, IV, SID/BID for 3-5 days. (as 10 mg per kg B.W) Or 1 ml/ kg, IV, SID/BID for 3-5 days (as 5 mg per kg B.W) DO DO Bolus Large animal: Orally: 1 bolus per 40-50 kg body weight for 5-7 days. (as 40-50 mg/kg BW) Intra-uterine: 4 boli directly or powdered for douche per 100 kg body weight. DO DO DO DO DO DO Powder 100 ml OPSO saline DO DO Synovia Beximco 2 gm bolus SQUARE Do DO Do Do Do Do ACME Bengal TECHNO POPULAR RENATA OPSONIN 37 Pulv. Dirovet Pulv. Acimetro vet Each gm contains, Metronidazole BP 300 mg DO Livestock: 4 g/25 kg body weight daily for 5-7 days. 100 gm Sachet Acme DO DO ACI Florfenicol Pharmacology/Actions: Like chloramphenicol, florfenicol is a broad-spectrum antibiotic that has activity against many bacteria. It acts by binding to the 50S ribosome, thereby inhibiting bacterial protein synthesis. (bacteriostatic.) Uses/Indications: The drug is FDA-approved for use in cattle only (in the USA) for the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis. Generic dose- Cattle/Sheep/Gaot: 20 mg/kg IM (in neck muscle only); repeat in 48 hours. Caution: Do not give this drug IV. Use in pregnancy & lactation: The effects of Florfenicol on bovine reproductive performance, pregnancy & lactation have not been determined. However, risk & necessity should be considered during administration of medicine in pregnant & lactating animals. Trade name Composition Trade Dose Vial size Company Inj. Uni-Flo 30 Each ml contains 7 ml/ 100 ml, IM daily 100 ml ACI Florfenicol BP 300 mg. (or 1 ml/15 kg) Inj. Amflor Vet Do IM/SC route 10 ml Acme Cattle 30 ml Treatment (SC): 2 ml/15 kg body weight, administered once. (as 40 mg/kg SC) Treatment (IM): 1 ml/15 kg body weight; repeat 48 hours later. Swine (IM) 1 ml/20 kg body weight, twice at a 48 hours interval. The injection should be given in the neck region. The dose should not exceed 3 ml per injection site. Inj. Amflor Vet Each ml contains 1 ml/7.5 kg body weight. Do Do Plus Florfenicol INN 300 mg & It is to be injected in Flunixin Meglumine- 16.5 subcutaneous route mg. preferably at neck region. Lincosamide + Aminocyclitol Lincomycin and Spectinomycin Description: The combination of Lincomycin and Spectinomycin acts as an additive and in some cases synergistic. Spectinomycin acts bacteriostatic or bactericidal, depending on the dose, against mainly Gram-negative bacteria like Campylobacter, E. coli, and Salmonella spp. Lincomycin acts bacteriostatic against mainly Gram-positive bacteria like Mycoplasma, Treponema, Staphylococcus and Streptococcus spp. Cross-resistance of Lincomycin with Macrolides can occur. Drug Species Dose Route Interval (hr) Spectinomycin Cattle 10–15 mg/kg SC q24h, 38 Horse Swine Swine 20 mg/kg, 10 mg/kg, 11 mg/kg for 3–5 consecutive days IM three times daily (q8h) PO/IM q12h IM q24h, for 3–7 days Lincomycin Indications : ✓ Cattle: Respiratory infections, arthritis, mastitis and omphalitis. ✓ Sheep & Goats: Respiratory infections, mycoplasmosis, and Foot rot. Use in Pregnancy and lactation: Safety of the product has been shown in cows during gestation and in suckling calves when used in cows. Trade name Composition Trade Dose Pack size Company Inj. Linospin Each ml injectable For IM or Subcutaneous 50 ml Bridge solution contains Injection. 100 ml Lincomycin hydrochloride Cattle, Sheep & Goats: 1 USP 50 mg and ml/10 kg body weight Spectinomycin Sulfate once daily for 4 days. USP 100 mg. Antibiotic Replacer/Antiviral Description: FRA C12 is the FRA C Lines No. 1 Product against gram positive pathogenic bacteria. This additive has proven to be up to 27 times more effective than other organic acids against gram positive pathogenic bacteria. Both field and lab trials have shown strong antiviral effects. This additive is available in liquid form, not pH dependent, odorless, heat stable up to 160 ˚ C and noncorrosive. FRA C12 is the first choice in prevention and controlling gram positive pathogenic bacteria such as Streptococcus, Staphylococcus, Enterococcus etc. Indications: ✓ Prevent and Control FMD, PPR, Rabies, Pox, Papilloma virus and also act against Flavi virus ✓ Prevent and Control gram positive pathogenic bacterial infections ✓ Improve feed conversion ratio & increase weight gain Trade name Composition Trade Dose Pack size Company Balanced mixture of Livestock: 1 gm/10 kg feed for 100 gm, Pulv. FRA C12 1-monolaurin and 10-15 days. ACI 500 gm essential oils. Drugs used to treat mastitis (Intra-mammary preparations) Indications: Treatment of mastitis in cattle and small ruminants. Application procedure: Before the introduction of the drug, milk (secret) from the affected quarter (share) of the udder is removed with subsequent disposal. Clean & disinfect teats. To inject the drug, the syringe cannula is inserted into the opening of the nipple and gently pressed on the plunger, squeezing out the contents. After administration of the drug, a gentle massage of the nipple from the bottom up is recommended. Trade name Composition Trade Dose Pack size Company Tube: Emulsion for topical use1 syringe/teat, SID, until 1 gm TECHNO Neomast-forte Each 1 g contains recovery. plastic 50 mg sulfadimezina, syringes/ 5.6 mg erythromycin, tubes/ 2.5 mg chinosol, glass vials 1 mg prednisolone, 8 mg of trimecaine and filler. 39 Neomast-forte: The drug has a bactericidal and bacteriostatic effect against staphylococci, streptococci and others, including penicillin-resistant pathogens mastitis. It has a local antiinflammatory, analgesic effect. Sulfadimesine is effective against antibiotic-resistant microorganisms. Erythromycin is an antibiotic from the macrolide group. In therapeutic doses has bacteriostatic effect. Erythromycin reversibly binds to the ribosomes of bacteria, thereby inhibiting protein synthesis. The spectrum of action includes gram-positive (Staphylococcus spp., producing and non-producing penicillinase; Streptococcus spp., including S. pneumoniae, Clostridium spp., Bacillus anthracis, Corynebacterium diphtheriae) and some gram-negative bacteria (Neisseria gonorrhoeae, Haemophillus 40abelled40, Bordetella pertussis, Brucella spp., Legionella spp.), Mycoplasma spp., Chlamydia spp., Spirochaetaceae, Rickettsia spp. Chinosol has a pronounced antimicrobial activity against most vegetative forms of microorganisms. Prednisolone has anti-inflammatory and mild analgesic effect. Trimekain relieves severe irritation in the pathological focus, turns off peripheral innervation, resulting in pain. Syringe. Each 1 ml contains, cattle – 1 syringe (10 ml) 10 ml ACI Mastilex cephalexin for each sick quarter of syringe monohydrate- 35 mg and the udder every 12-24 gentamicin sulfate-3.5 hours (no more than 3 mg times); Small ruminants – 0.5 syringe (5 ml) for each sick lobe every 12 – 24 hours (no more than 3 times). Mastilex: The antibacterial effect of the drug is due to the effects of antibiotics included in its composition. Cephalexin, from the group of cephalosporins, is active against gram-positive microorganisms. Gentamicin, from the aminoglycoside group, has a bactericidal effect against a wide range of gram-negative microorganisms, and complements the action of cephalexin. Tube. Mastijet Each injector of 8 gram One injector per infected 8 gm tube Intervet Forte contains: quarter every 12 hours, Tetracycline-200 mg with a maximum of four Neomycin-250 mg treatments. Bacitracin-2000 IU Prednisolone-10 mg Mastijet Fort is an intramammary injector for use in lactating cattle. The combination of antibiotics used in Mastijet Fort ensures a broad spectrum of activity covering all the commonly occurring mastitis-causing bacteria. The ingredient Prednisolone decreases the inflammatory reactions and promotes a decrease of the somatic cell count and a rapid return to milk production. Syringe. 1 syringe contains Instill 1 syringe (injector) 7.5 gm Arifs Gentamast Gentamicin sulfate-170 per infected quarter. If syringe mg necessary, repeat instillation after 24 hours up to 3 consecutive days. 40 Drugs used to treat subclinical mastitis Indications: ✓ Sub-clinical Mastitis. ✓ Adjunct to Antibiotic therapy on Clinical Mastitis. Trade name Composition Trade Dose Pack size Company Pulv. Mastinor Each 60 gm contains: Prevention: 60 gm Popular Tri Sodium Citrate: 25 gm 30 g per day one week sachet Vitamin A: 10000 IU before calving and one Vitamin D3: 2000 IU week after calving Vitamin E: 800 mg Control: Vitamin H (Biotin): 20 mg Large animals – 60 g for Vitamin K: 20 mg 4 days as per Selenium: 4 mg recommended Potassium Iodide: 4 mg administration guide Copper Sulphate: 960 mg (1st Day – 60 g per day, Cobalt Sulphate: 40 mg followed by 30 g BID Zinc Sulphate: 825 mg for 3 days) Manganese Sulphate: 3000 Small animals – 20 g to mg 25 g for 3 to 4 days Lactic Acid Bacillus: 200 million CFU MASTINOR should be Live Yeast: 50000 million CFU administered orally, Serratiopeptidase: 32 mg mixed in jiggery or as Bromelain: 320 mg an electuary Methionine: 1500 mg L-Lysine: 3000 mg Fortified with Natural AntiMastitic Actives Pharmacology of Mastinor : Mastinor is unique combination of anti-mastitis preparation used to prevent and control of Clinical and sub-clinical mastitis. Tri-Sodium citrate act as a most effective buffer which regulates ca++ & H+ in the udder and maintain normal pH. Vitamins containing in mastinor act as antioxidant, maintain udder epithelial tissue health, improve immune function and reduce somatic cell count. Mastinor includes unique component like bromelain & serratiopeptidase which are special type of enzyme has antiinflammatory, antithrombotic and fibrinolytic properties and it also helps to transport antibiotic to target site. Other ingredients like Mineral, Probiotic and Amino acid works synergistically to prevent mastitis. Pulv. Each 100 gm Powder For Pregnant and 100 gm SQUARE Masticare plus contains lactating cow: 30 gm container Vitamin A – 5000 IU, twice daily for 3 to 5 Lactobacillus -100 Million days. Spores Amino Nitrogen -166.67 mg with fortified calcinated base Mode of Action of Masticare plus: Vitamin A: It promotes epithelial integrity, secretory activity and restoration of damaged mucosa, prevent scar tissue formation. Lactobacillus: It competitively antagonizes and inhibits pathogenic organism. 41 Aminonitrogen: It induces non-specific immunity by way of reactive proteins and is also bacteriostatic and bactericidal through Lactoperoxidase system. And also improve the levels of transferrins and lactoferrins. Pulv. No-Masti Each 100 gm powder Use No Masti Plus for 100 gm ACI plus contains: pregnant and lactating Sachet cattle: Bacillus subtilis: 3.2 X 106 Large animals (Cow, CFU Buffalo, Camel & 1-Monolorin: 60 gm Horse): 25-30 gm twice Nano zinc oxide: 5 gm daily for 3-5 days. Sweet chestnut extract: 5 gm Small animals (Goat, DL-methionine: 1.50 gm Sheep, Dog & Cat): 5Calcium carbonate: 8.50 gm 10 gm twice daily 3-5 Essential oil: 100 gm days. No-Masti plus: Prevents and controls all types of mastitis in all mammals. Pulv. Each 60 g contains For use in animal feed. 120 gm Acme 8 PROMAST VET Lactobacillus spp-2 x 10 CFU, Safe in pregnant & container Live yeast-5 x 1010 CFU, lactating animals. (A unique Serratiopeptidase-60 mg, Cattle & buffalo: 60 g combination Bromelain-320 mg, Trisodium once daily for 3-5 days. of probiotic, citrate-35 g, MethionineGoat, sheep & pig: 20live yeast, 1500 mg, L-Lysine-3000 mg, 30 g once daily for 3-5 enzyme, Vitamin A-10000 IU, Vitamin days. buffer, D3-2000 IU, Vitamin E-800 The above dosage & vitamin, mg, Vitamin C-100 mg, Biotin administration mineral & 200-mcg, Copper-960 mg, schedule should be amino acid) Potassium iodide-4000 mg, followed with feed Zinc sulphate-825 mg, twice in every month to Manganese sulphate-3000 ensure optimum result. mg, Selenium-4 mg, Cobalt40 mg. Indication: For the prevention & supportive therapy of Mastitis. Antibiotic Eye drops Mode of Action: Fibrolytic action thus reduce corneal opacity of eye Indication: Acute and chronic keratitis and conjunctivitis of an infectious, allergic but non-viral nature. It is also indicated in chronic anterior 42abelle, scleritis, episcleritis, myositis and corneal injury from chemical radiation or thermal burns, or penetration of foreign bodies. Post-operative management of cataract, glaucoma, and strabismus. Trade name Composition Trade dose Vial size Company Drop. Civodex vet Each ml drops contains: 2-3 drops into 5 ml POPULAR Dexamethasone BP 1 conjunctival sac(s) every mg. four to six hours. Ciprofloxacin Hydrochloride BP 3 mg. Preservative: Benzalkonium Chloride 0.1 mg. Drop. Silver AgNO3: 10 mg/ml Do 10 ml CHEMIST Nitrate 1% (1 %) 42 (AgNO3) Drop. Optabac Chloramphenicol- 5 Do 10 ml mg/ml Drop. Cipro-A Ciprofloxacin: 3 mg/ml Do 5 ml (0.3%) Drop. Genta Gentamicin-3 mg/ml Do 10 ml (0.3%) Drop. Chlorodex Dexamethasone + Do 5 ml Chloramphenicol: (1 mg (0.1%) + 5 mg (0.5%) /ml Drop. Dexonex-C Do Do Drop. Iventi Moxifloxacin: 5 mg/ml Do 5 ml (0.5%) Drop. Intobac Tobramycin: 3 mg/ml Do 10 ml (0.3%) Drop. Cinarex Do Do 5 ml Drop. Povisep Povidone Iodine-1.25% Do 5 ml Drop. Bludrop Do Do Do (all are Human preparation except Civodex vet & silver nitrate) POPULAR ACME RENATA NIPA Square Square Incepta Beximco Jayson Healthcare Anti Glaucoma Eye drops Drop. Brimodin plus Drop. Timodin Brimonidine Tartrate & Timolol maleate: 2 mg/ml (0.2%) + 5 mg/ml (0.5%) DO Instill 1 drop in affected eye 2 times/day, approximately 12 h apart. 5 ml Incepta Do 5 ml Do (all are Human preparation) 5 ml Opso saline Beximco Drop. Cinarex Do Vial size 5 ml Company ACME 5 ml Aristophar ma Do Do 10 ml Incepta Popular Square Antibiotic Ear drops Indication: Otitis media, Otitis externa. Trade name Composition Trade dose Drop. Cipro-A Ciprofloxacin: 3 mg/ml Instill 2-4 drops in (0.3%) affected ear 2 times/day Drop. Aprodex Dexamethasone (0.1%) Do + Ciprofloxacin Hydrochloride (0.3%): (1 mg + 3 mg) / mL Drop. Beuflox-d Do Do Drop. Civodex Do Do Drop. Genacyn Gentamicin: 3 mg/ml Do (0.3%) (all are Human preparation) Antibiotic Topical preparations Trade name Composition Trade dose Vial size Company 43 Ointment Indication: Ointment may be used in the treatment of infected wounds, burns or skin grafts. Oint. Renamycin Oxytetracycline-3 mg Apply to the affected 5 gm RENATA & polymyxin Barea 2-3 times daily. sulphate 10,000 units per 1 gm. Oint. Povin Povidone Iodine- 5% Do 10 gm OPSONIN Oint. Betadine Do Do Do Mundipharma Oint. Viodin Do Do Do Square Oint. Nebanol Neomycin sulphate + Do Do SQUARE Bacitracin zinc: 5 mg + 500 IU/gm Oint. Nebanol Each gram of Ointment Do Do Square Plus contains: Neomycin Sulphate BP- 3.5 mg Bacitracin Zinc BP- 400 IU Polymyxin B Sulphate BP- 5000 IU Oint. Neobet 5 Neomycin sulphate + Do Do ACME Betamethasone: (5 mg + 1 mg) / gm Oint. Bactrocin Mupirocin- 100 mg/gm Do Do Square 2% Oint. Genacyn Gentamicin- 1 mg/ gm Do Do Square (0.1%) Powder Indication: ✓ It is used as a dusting powder for wounds by topical application. ✓ It is also used to treat infections caused by sulfonamide sensitive organisms, notably streptococcal septicaemia; equine pneumonia caused by streptococci; strangles, joint-ill; metritis in mares, cows and ewes. Pulv. Sulphavet Sulphanilamide: 1 gm/ For topical10 gm ACME gm As a dusting powder sachet apply into the sore as required for 2-3 times daily. For OralAnimals up to three months of age: Initial dose: 7.5 g/50 kg body weight. Continuation: 2.5 g/50 kg body weight every eight hours. Older animals: Initial dose: 10 g/50 kg body weight. 44 Pulv. Sumid-Vet Pulv. Nilamide Continuation: 5 g/50 kg body weight every twelve hours. Total period of treatment should not exceed seven days. Do Do Do Do Do Do SQUARE TECHNO Antifungal drugs Griseofulvin Mode of action: Dermatophytes concentrate griseofulvin via an energy-dependent process. Griseofulvin then disrupts the mitotic spindle by interacting with the polymerized microtubules in susceptible dermatophytes. This leads to production of multinucleate fungal cells. The inhibition of nucleic acid synthesis and the formation of hyphal cell wall material also may be involved. The result is distortion, irregular swelling, and spiral curling of the hyphae. Griseofulvin is fungistatic rather than fungicidal, except in young active cells. Indication: Fungistatic antibiotic used primarily for ringworm. Griseofulvin has activity against species of Trichophyton, Microsporum and Epidermophyton. Only new hair and nail growth is resistant to infection. It has no antibacterial activity and is not clinically useful against other pathogenic fungi, including Malassezia yeasts. Contraindications: Pregnancy, known hypersensitivity, or hepatocellular failure. Geneic Dose: Species Dose Route Interval (hr) Cattle Ultramicrosize: 10–20 mg/kg PO once daily for 1–2 weeks Horse microsize: 5 mg/kg PO once daily Swine 20 mg/kg PO once daily for 6 weeks Trade name Bol. Dermaphyl Vet Composition Griseofulvin: 2.5 gm Trade dose Cattle, Horse: 1 bolus/250 kg, (10 mg/kg BW) for 7 days in mild infection and 2-3 weeks in severe infection. Vial size 2.5 gm bolus Company Navana Azoles Mode of action: The azoles inhibit the synthesis of ergosterol in fungal cytoplasmic membranes by blocking cytochrome P450 enzymes and increasing cellular permeability. At high doses, mammalian steroid synthesis (corticosteroids and sex steroids) is inhibited. Azoles are fungistatic for most pathogenic fungi causing systemic infections such as Blastomyces, Coccidioides, Cryptococcus, and Histoplasma spp. They are also effective against candidiasis and griseofulvin-resistant dermatophytes. Use in Pregnancy and lactation: Not safe. Potentially teratogenic & embryotoxic. Drug Species Dose Route Interval (hr) Ketoconazole Horse 30 mg/kg PO q12–24h Ruminant 10 mg/kg PO 24 h Fluconazole Horses Loading dose-14 mg/kg, PO q 24 h followed by 5 mg/kg Itraconazole Horse 3 mg/kg PO q12h for up to 2 months 45 Ketoconazole Uses/Indications: has activity against most pathogenic fungi, including Blastomyces, Coccidioides, Cryptococcus, Histoplasma, Microsporum, and Trichophyton. Higher levels are necessary to treat most strains of Aspergillus and Sporothrix. Resistance to ketoconazole has been documented for some strains of Candida albicans. Contraindication: is contraindicated in hepatic disease. Trade name Composition Trade dose Vial size Company Tab. Ketoral Ketoconazole: 200 1 tab/20 kg BW, PO 200 mg SQUARE mg/tab (as 10 mg/kg) tablet Tab. Ketocon Do Do Do OPSONIN Fluconazole Uses/Indications: may have use in veterinary medicine in the treatment of systemic mycoses, including cryptococcal meningitis, blastomycosis, and histoplasmosis. It may also be useful for superficial candidiasis or dermatophytosis. Contraindication: Renal failure (dosage adjustment needed), hepatic failure. Trade name Composition Trade dose Vial size Company Tab. Canazole Fluconazole: 200 1 bol/ 40 kg BW, PO 200 mg Aci mg/tablet (as 5 mg/kg) tablet Tab. Flucon DO DO DO Opsonin Tab. Flugal DO DO DO Square Susp. Flugal Fluconazole: 10 mg/ml 1 ml/ 2 kg 35 ml Square Susp. Lucan DO DO DO Renata Susp. Fluconal DO DO DO Acme Itraconazole Uses/Indications: may have use in veterinary medicine in the treatment of systemic mycoses, including aspergillosis, cryptococcal meningitis, blastomycosis, and histoplasmosis. Itraconazole is probably more effective than ketoconazole, but is significantly more expensive. It may also be useful for superficial candidiasis or dermatophytosis. Itraconazole does not have appreciable effects (unlike ketoconazole) on hormone synthesis and may have fewer side effects than ketoconazole in small animals. Trade name Composition Trade dose Vial size Company Cap. Itra Itraconazole: 200 1 tab/ 67 kg BW, PO 200 mg SQUARE mg/tablet (as 3 mg/kg) tablet Cap. Itracon DO DO DO Navana Nystatin Mode of action: It binds to sterols in the membrane of the fungal cell altering the permeability of the membrane allowing intracellular potassium and other cellular constituents to “leak out.” When given orally, the drug must come into contact with the organism to be effective. Uses/Indications: Nystatin has activity against a variety of fungal organisms, but is clinically used against topical, oropharyngeal, and gastrointestinal Candida infections. Species Dose Route Interval (hr) Horse 250,000–1,000,000 IU Intrauterine Ruminant 5000-10000 IU/kg b.w. PO 8-12 h Use in Pregnancy and lactation: pregnancy safety not established. Trade name Composition Dose Pack size Company Tab. Nystat Nystatin: 500,000 IU/ tablet Ruminant: 5 lac unit tablet ACME 46 Tab. Canstat DO 1 tab/ 100-50 kg BW, PO. DO Tab. Mycocin Susp. Nystat DO Nystatin: 100,000 IU/ml DO 1 ml/ 20 kg BW, PO DO 30 ml Ibn sina ACME Susp. Candex Susp. Fungistin DO DO DO DO DO DO SQUARE Beximco DO JAYSON Topical anti-fungal preparation Whitfield’s ointment Indication: Hyperkeratosis, parakeratosis, fungal dermatitis. Application: Applied locally after washing with luke warm water Trade name Composition Dose Oint. Dermin Oint. Whitfield Oint. Bensal Benzoic acid- 6%, salicylic acid- 3%, Vaseline- 91% Do Do Apply locally on the affected area 2-3 times/day. Do Do Pack size Company 25 gm tube JAYSON Do Do Asiatic G.A. Antiparasitic drugs Antinematodal drugs These drugs are classified as follow: 1. Simple heterocyclic compounds: Phenothiazine, Piperazine 2. Benzimidazoles: Thiabendazole, albendazole, fenbendazole, Mebendazole, oxfendazole, oxibendazole, and febantel. 3. Imidazothiazoles: Butamisole hydrochloride, Levamisole. 4. Tetrahydropyrimides: Pyrantel, Morantel 5. Organophosphorous compounds: Crufomate, Haloxan, Coumaphos, Diclorvos, Trichlorfon. 6. Miscellaneous: Toluene, Tetrachloroethane, Avermectins Piperazine Mechanism of action: Piperazine is a GABA-receptor agonist that hyperpolarizes nematode muscle, causing flaccid paralysis of worms. Indication: Ascaris, Oxyuris, some Strongyloides & Trichuris. Species Dose Route Interval (hr) Dog, Cat 110 mg/kg PO repeat in 21 days Ruminant 100 mg/kg PO Horse 110 mg/kg PO; repeat in 3–4 weeks Swine 110 mg/kg PO In feed 0.2–0.4% Use in Pregnancy: Piperazine is considered safe to use in animals with concurrent gastroenteritis and during pregnancy. Trade name Composition Dose Pack size Company Pulv. Piper-Vet Water soluble powder containing Piperazine Citrate USP 100%. Cattle, Buffalo: 25-50 gm / 100 kg body weight. Horse: 25-30 gm / 100 kg body weight 100 gm 500 gm pack. Square 47 Pulv. Razinmax Vet Pulv. Peravet Do Sheep, Goat: 4-8 gm / 10 kg body weight. Dog, Cat: 1-2.5 gm / 10 kg body weight. Do Do Do Pulv. Perazin Do Pulv. Eskapar Pulv. Helmacid Vet Do Incepta Acme Do 10 gm, 100 gm, 500 gm Do Techno Do Do Do Sk+F Do Cattle, Buffalo, Horse : 1025 gm per 100 kg body weight. Sheep, Goat : 3-5 gm per 10 kg body weight. Dog, Cat: 0.1-0.25 gm per kg body weight. 20 gm, 100 gm, 500 gm Al-Madina Benzimidazoles (BZD) Mechanism of action: BZDs inhibit microtubule synthesis in nematode cells by interfering with polymerization of β-tubulins. BZDs do not affect microtubule synthesis in animal cells, this is why these drugs are relatively safe in animals. Care should be exercised for some of the BZDs (albendazole) if the animal is in the first one-third of pregnancy. BZDs Preparations: Thiabendazole, albendazole, fenbendazole, Mebendazole, oxfendazole, oxibendazole, and febantel. Albendazole Uses/Indications: broad-spectrum dewormer. Cattle (not lactating): Ostertagia ostertagi, Haemonchus spp., Trichostrongylus spp., Nematodius spp., Cooperia spp., Bunostomum phlebotomum, Oesphagostomum spp., Dictacaulus vivaparus (adult and 4th stage larva), Fasciola hepatica (adults), and Moniezia spp. Sheep/goats: Ostertagia circumcincta, Marshallagia marshalli, Haemonchus contortus, Trichostrongylus spp., Nematodius spp., Cooperia spp., Oesphagostomum spp., Chibertia ovina, Dictyocaulus 48iviparous, Fasciola hepatica, Fascioides magna, Moniezia expansa, and Thysanosoma actinoides. Horses: Roundworms, Pinworms, Lungworms. Albendazole is also used (extra-label) in small mammals and swine for endoparasite control. Species Dose Route Interval Cattle, Sheep, goat 7.5–15 mg/kg PO Horse 25–50 mg/kg for PO 2–5d Swine 5–10 mg/kg PO Contraindication: hepatic failure. Use in Pregnancy and lactation: not safe. Trade name Composition Dose Pack size Company Bol. Almex vet Each bolus contains Albendazole USP 600 mg. Bol. Helmex Do 1 bolus/ 60 kg BW, orally (as 10 mg/kg) Do 600 mg bolus SQUARE Do RENATA 48 Bol. Alben vet Bol. Aldazole Bol. Benazole Bol. Alrex vet Bol. Bre-Zol Do Do Do SK+F Do Do Do TECHNO Do Do Do ACME Do Do Do Gentry Do Do Do bridge Bol. Relaben Vet Susp: Alben Vet Do Do Do Bengal Each mL solution contains Albendazole BP 100 mg Round worm: 1 ml /10 kg body weight (as 10 mg / kg BW) Tape worm: 1 ml / 5 kg body weight (as 20 mg / kg) 20 ml, 100 ml 500 ml bottle SK+F Fenbendazole Uses/Indications: broad-spectrum dewormer. Cattle: Adult forms of Haemonchus contortus, Ostertagia ostertagi, Trichostrongylus axei, Bunostomum phlebotomum, Nematodirus helvetianus, Cooperia spp., Trichostrongylus colubriformis, Oesophagostomum radiatum, and Dictyocaulus vivaparus. It is also effective against most immature stages of the above listed parasites. Although not FDA-approved, it has good activity against Moniezia spp., and arrested 4th stage forms of Ostertagia ostertagi. Horses: large strongyles (S. endentatus, S. equinus, S. vulgaris), small strongyles (Cyathostomum spp., Cylicocylus spp., Cylicostephanus spp., Triodontophorus spp.), and pinworms (Oxyuris equi). Swine: large roundworms (Ascaris suum), lungworms (Metastrongylus pair), nodular worms (Oesphagostomum dentatum, O. quadrispinolatum), small stomach worms (Hyostrongylus rubidus), whipworms (Trichuris suis), and kidney worms (Stephanurus dentatus; both mature and immature). Although not FDA-approved, fenbendazole has been used in cats, sheep, goats, pet birds, and llamas. Species Dose Route Interval Cattle, Horse 5–10 mg/kg PO for 3d Calves For giardiasis : 15 mg/kg, for 3 successive days PO Sheep, goat 5 mg/kg PO for 3d Swine 5–10 mg/kg PO Use in Pregnancy and lactation: is generally considered safe to use in pregnancy for all species. Trade name Composition Dose Pack size Company Bol. Peraclear Bol. Fenazol vet Bol. Refenda Vet Liq. Fenazol vet Fenbendazole: 250 mg/ bolus DO 1 bol / 50 kg BW (as 5 mg/kg) DO 250 mg bolus DO TECHNO DO DO DO Bengal Each ml contains Fenbendazole BP 200 mg. Cattle: 1 ml/25 kg body weight as a single dose Horse: 1 ml/20-40 kg body weight as a single dose. 100 ml, 500 ml ACME ACME 49 Mebendazole Uses/Indications: broad-spectrum dewormer. Active against nematode, trematode & Cestode. Trade name Composition Dose Pack size Company Bol. Nemadex Each bolus contains Mebendazole 750 mg. Orally Cattle- 1 bolus/50-100 kg BW. Sheep, Goat- ¼ of 1 bolus per animal. (as 10-15 mg/kg, BW) Horse: 1 bolus / 75-150 kg BW (as 5-10 mg/kg BW) 750 mg bolus Super power Levamisole Mechanism of action: Levamisole paralyzes worms by selectively activating nematode nicotinic acetylcholine (Ach) receptors, allowing entry of Na+, Ca2+, for excessive body muscle contraction, and thus induces paralysis. It has immune-modulatory action. Indication: Ruminant: Stomach : Haemonchus, Ostertagia sp etc. Small Intestine : Cooperia, Trichostrongylus, Bunostomum, Nematodirus etc. Large Intestine : Oesophagostomum, Trichuris, Chabertia etc. Lung : Dictyocaulus viviparous. Swine: Ascaris suum, Oesophagostomum spp., Strongyloides, Stephanurus, and Metastrongylus. Species Dose Route Interval Cattle 5.5–11 mg/kg PO 3.3–8 mg/kg SC Sheep, goat 7.5 mg/kg or 8 mg/kg PO Swine 8 mg/kg PO Camelids: Llamas 5–8 mg/kg IM/PO Use in Pregnancy and lactation: is relatively safe to use in large animals that are pregnant. Adverse effects: Cattle: muzzle foaming or hypersalivation, excitement or trembling, lip-licking and head shaking. These effects are generally noted with higher than recommended doses. Sheep: a transient excitability in some animals after dosing. I Goats: depression, hyperesthesia, and salivation. Injecting levamisole SC in goats apparently causes a stinging sensation. Swine: salivation or muzzle foaming. Swine infected with lungworms may develop coughing or vomiting. Contraindication: Levamisole is contraindicated in lactating animals (not approved). It should be used cautiously, if at all, in animals that are severely debilitated, or significant renal or hepatic impairment. Trade name Composition Dose Pack size Company Inj. Clomisole (vet) Bol. Levavet Bol. Vaminil vet Each ml contains, Levamisole (hydrochloride)- 100 mg Closantel BP- 75 mg Each bolus contains Levamisole (as HCl) BP 600 mg. Do Cattle: 0.3-0.5 ml/10 kg BW, deep IM route. Sheep: 0.3-0.5 ml/10 kg BW, subcutaneous route. 1 bolus/ 41-75 kg BW. Do 10 ml 50 ml 100 ml Bridge 600 mg bolus ACME Do Popular 50 Bol. Ralnex. Do Do Do Novartis Syp. Neotrax vet Each ml contains Levamisole Hydrochloride BP 10 mg. 15 ml/ 10-20 kg b.w PO. Or 1 ml/kg BW PO (as 10 mg/kg) 30 ml ACME Ivermectin Mode of action: Ivermectin enhances the release of gamma amino butyric acid (GABA) at presynaptic neurons. GABA acts as an inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron in nematodes or the muscle fiber in arthropods. By stimulating the release of GABA, ivermectin causes paralysis of the parasite and eventual death. As liver flukes and tapeworms do not use GABA as a peripheral nerve transmitter, ivermectin is ineffective against these parasites. Indication: Both ectoparasites and endoparasites. Internal Parasites 1. Gl nematodes of cattle, sheep, goat, swine, buffalo and camel: Haemonchus, mecistocirrus, ostertagia, trichostrongylus, strongyloides, cooperia, nematodirus, oesophagostomum, toxocara vitulorum, trichuris, chabertia, bunostomum, ascaris, hyostrongylus, metastrongylus, stephanurus etc. 2. Nematodal eyeworms of cattle: Thelazia spp. 2. Nematodes of lung: Dictyocaulas viviparous in cattle and deer. Dictyocaulas viviparous in sheep, goat and wild ruminants, protostrongylus rufescens in sheep, Dictyocaulus arnfieldi in horse. 3. GI Nematodes of Horse: Strongylus spp. Oxyuris equi, parascaris equorum, Hebronema spp. Trichostrongylus axei, strongyloides etc. External parasites i) Arthropod Parasites: In cattle: Warble fly—Hypoderma bovis Myiasis by screw worm fly—Crysomya bezziana Sucking lice—Linognathus, Haematopinus Biting lice—Damalinia Mites—Sarcoptes, psoroptes, chorioptes, demodex Tick—Boophilus ornithodorus. In Horse: Gastrophillus spp. In Swine: Lice—Haematopinus & mange mite—sarcoptes In sheep: Nasal bot by Oestrus ovis, Mites—Sarcoptes, chorioptes, demodex. ii) Nematodes: In Cattle: Humpsore causing nematode-stephanofilaria assamensis infestation. Species Dose Route Interval Cattle, sheep, goat, camelids 0.2 mg/kg (200 mcg/kg) BW SC Horse, 0.2 mg/kg (200 mcg/kg) BW PO Pig 0.3 mg/kg (300 mcg/kg) BW SC Use in Pregnancy and lactation: Ivermectin is considered safe to use during pregnancy. Ivermectin is 10 times safe in ruminants. Trade name Composition Trade dose Pack size Company 1 ml / 50 kg BW, SC, single dose. Each ml contains N.B. In case of Humpsore in cattle, 5 ml, Inj. Vermic Ivermectin: 10 mg TECHNO the dose may be repeated after 28 10 ml (1%) days. Inj. Acimec DO DO DO ACI 1% 51 Inj. A-mectin Vet Inj. Parasitin vet Inj. Intermectin Vet Inj. Parakil vet Inj. Vetmectin DO DO DO DO DO DO DO DO DO Inj. Invet DO A-mectin vet Each ml contains Ivermectin: 5 mg I-POUR Normectin DO DO ACME Square Bengal DO DO DO DO DO 5 ml, 10 ml 30 ml DO DO Pour on Livestock: Pour on slowly from the withers to tailhead at a dose of 1 ml /10 kg body weigh (1 ml=50 drops) DO DO Incepta Albion Popular 15 ml dropper bottle ACME Do 250 ml Albion SQUARE Antitrematodal /Fasciolicidal drugs These drugs are classified as follow: 1. The bisphenolic compounds: Hexachlorophene, Oxyclozanide. 2. The nitrophenolic compounds: Disophenol, Niclofolan, Nitroxynil 3. The salicylanilides: Closantel, Brotianide, Rafoxanide. None of these compounds are available as trade drugs in the local market. 4. The sulphonamides: Clorsulon 5. The Benzimidazoles: Albendazole, Triclabendazole etc Oxyclozanide Mode of action: Uncoupling of electron transport system. Indication: effective against liver fluke and rumen fluke. Generic dose: 18.7 mg/kg BW, twice at 3 days interval. Use in Pregnancy: Not safe. Trade name Composition Trade dose Oxyclozanide- 1000 Bol. Tremacid 1 bolus/ 100 kg BW, PO mg/ bolus Pack size Company 1 gm bolus RENATA Oxyclozanide + Tetramisole Mode of action: Tetramisole causes the neuromuscular paralysis of the worms & expels from host within 24 hours. Oxyclozanide inhibits oxidative phosphorylation of worms rendering destruction of metabolic processes resulting in death of worms. Indication: This is a broad spectrum anthelmintic. It is active against liver fluke, roundworm, lungworm, whipworm, Paramphistomum spp. Moniezia spp. Etc. in livestock. Use in Pregnancy: Do not administer during the first 3 (three) months of pregnancy. Trade name Composition Trade dose Pack size Company Each bolus contains For oral administration only. 5 x 4 Bolus Bol. Levanid Tetramisole -2 gm Administer 1 bolus/100-150 kg in blister ACME Vet Oxyclozanide- 1.4 body weight. This bolus may be Strips gm administered with water or 52 Bol. Trox Bol. Tetranid Bol. TcloVet Bol. O-TVET DO DO DO DO with feed (like molasses) or wrapping with banana-leaf directly. DO DO DO DO DO DO DO DO CHEMIST TECHNO Bengal Bridge Nitroxynil Mode of action: Uncoupling of electron transport system. Indication: for the treatment of fascioliasis (infestation of both mature & immature fasciola), adult and larval stages of Haemonchus contortus in cattle and sheep and Haemonchus placei, Oesophagostomum radiatum and Bunostomum phlebotomum in cattle. Generic dose: 10 mg/kg BW, SC. Use in Pregnancy: safe. Precaution: injection is not for intravenous or intramuscular use. Trade Name Composition Trade dose Vial size Company Each ml injectable solution contains 1.5 ml of per 50 kg body lnj. Nitrox-A Nitroxynil BP (Vet) 340 weight, SC. 10 ml ACME mg. (as 10 mg/kg) (34% solution) lnj. Nitronex Do Do 10 ml, 30 RENATA 34% ml Inj. Bentronil Do Do Do Bengal Vet 1 ml per 25 kg body weight. (as 10 mg kg) Each ml contains 10 ml, 50 Inj. Navet Next Dosage: in case of POPULAR Nitroxynil BP 250 mg. ml massive infestation repeat, if necessary after 3 weeks. Inj. Oxynil Do Do Do TECHNO Inj. Niloxin Do Do Do SK+F Triclabendazole Pharmacology: Triclabendazole is the most recent derivative of Benzimidazoles. It is highly effective against all stages of liver flukes, from 1 day old to adult. Benzimidazoles bind to β-tubulin, a structural protein, and block polymerization of tubulin into microtubules. This damages the integrity & transport functions of cells within the parasite and ultimately kills the parasite. Indication: Triclabendazole is used for the eradication of mainly Liver fluke also indicated Round worm, Tape worm etc. Generic dose: Cattle: 12 mg/ kg BW, PO. Sheep: 10 mg/kg BW, PO. Goat: 5 mg/kg BW, PO Use in Pregnancy: safe. Trade Name Composition Trade dose Vial size Company Triclabendazole-900 900 mg Bol. Acinex 1 bolus/41-75 kg body weight ACI mg/ bolus bolus Do Do Do Bol. Fasinex Novartis Do Do Do Bol. Fasinil TECHNO 53 Anticestodal drugs These drugs are 1. Bunamidine Hydrochloride 2. Niclosomide 3. Praziquantel 4. Benzimidazoles: Albendazole, Fenbendazole, mebendazole. Niclosamide Indication: Treatment of tape worm (Moniezia spp., Stilesia spp., Avitellina spp.) and immature intestinal paramphistomiasis (Amphistomiasis), intestinal schistosomiasis of Cattle, Sheep and Goats. It has 5-7 times safety. Generic dose: Cattle: 50 mg/kg BW, PO. Sheep/Goat: 100 mg/kg BW, PO. Use in Pregnancy: safe Trade Name Composition Trade dose Vial size Company Bol. Niclovet Niclosamide: 1000 1 bolus/20 kg BW, PO. 1 gm FnF mg/bolus This bolus may be bolus administered with water or with feed (like molasses) or wrapping with banana-leaf directly. Bol. Mensonil Do Do Do Super power Bol. Niclosam Do Do Do CHEMIST Antinematodal + Antitrematodal preparation Triclabendazole + Levamisole Indication: is a highly effective flukicide & nematodicide. All types of fascioliasis i.e. acute, sub-acute and chronic caused by Fasciola hepatica and Fasciola gigantica can be effectively treated. Major ruminant parasites of the stomach and intestine viz Haemonchus & Ostertagia of the abomasum, Cooperia, Trichostrongylus & Bunostomum of the small intestine, Oesophagostomum & Trichuris of the large intestine as well as the Dictyocaulus spp. of the lungs are satisfactorily removed by this broad spectrum anthelmintic. Safety index: Triclabendazole is the safest flukicide discovered so far, with safety index of about 16 times and the safety factor of Levamisole is about 3 times than the recommended dosages. Use in Pregnancy: In recommended dosage the drug does not have effect on pregnancy. The drug has got no embryotoxic or teratogenic effect. Precaution: Adequate water intake should be maintained during and after therapy. Trade Name Composition Trade dose Vial size Company 19.5 mg per kg body wt. Or 1 bolus/ 41-75 kg body wt. Each bolus contains Bolus can be administered Triclabendazole INN orally either by dissolving in 1500 mg Bol. Endex Novartis 900 mg & Levamisole water and given as a drench or bolus BP 600 mg by mixing with any feed (e.g. with molasses or by wrapping in a banana leaf) and feeding it to the animal or to be 54 Bol. Renadex Bol. An-Worm Bol. Trilev-vet Bol. Antiworm Bol. LT Vet Bol. Ltzol vet Bol. L-Trivet Bol. ALBIDEX 1500 Bol. Doubledex Bol. LT Vet DS Bol. Duozol DS Vet Do Do Do Do dispensed only by or on the prescription of a registered veterinary doctor. Do Do Do Do Do Do Do Do RENATA Al-madina SQUARE Do Do Do Do Do Do Do Do Do Do Do Do ACME POPULAR Bridge 1 bolus/ 150 kg body weight (19.5 mg /kg body weight). 1800 mg + 1200 mg bolus Do Do Do Do Each bolus contains Triclabendazole BP 1800 mg & Levamisole Hydrochloride- 1200 mg Do Do ACI Albion SK+F ACME Incepta Ivermectin + Clorsulon Mode of action of clorsulon: In susceptible flukes, clorsulon inhibits the glycolytic enzymes 3phosphoglycerate kinase and phosphoglyceromutase, thereby blocking the Emden-Myerhof glycolytic pathway; the fluke is deprived of its main metabolic energy source and dies. Indication of clorsulon: Adult flukicide (Fasciola hepatica, Fasciola gigantica, F. magna). Clorsulon is not effective against the rumen fluke (Paramphistomum). Generic dose of clorsulon: Cattle, sheep, goat, Llamas—2 mg/kg, SC. or 7 mg/kg PO. Use in Pregnancy and lactation: is considered safe to use in pregnant or breeding animals. Pack Trade name Composition Trade dose Company size Inj. Each ml contains 5 ml, A-mectin Ivermectin: 10 mg & 1 ml / 50 kg BW, SC, single dose ACME 30 ml plus vet Clorsulon-100 mg Inj. Iveclor DO DO 5 ml RENATA Ivermectin + Triclabendazole Trade name Composition Trade dose Pack size Company Each ml Suspension contains, Ivermectin Cattle: 1 ml per 10 kg bodyweight, Suspension. BP 2 mg & It is given orally. Should shake well 50 ml Square Iverzol-Vet Triclabendazole INN before use. 120 mg. Indication: Iverzol-Vet Suspension is indicated for the control of adult and immature (including inhibited stages) ivermectin-sensitive gastrointestinal nematodes, lung worms, sucking lice, Itch mite and nasal bots in sheep and adult, immature and early immature liver flukes in cattle and sheep. 55 Fly repellent Trade name (Trichlorfon, Metrifonate, Cypermethrin, Dressgel-FR) Composition Trade dose Pack size Trichlorfon Company Description : Trichlorfon (USAN) is an irreversible organophosphate acetylcholinesterase inhibitor. It is used as an insecticide. Indications: • Trichlorfon is an organophosphate insecticide used to control cockroaches, crickets, silverfish, bedbugs, fleas, cattle grubs, flies, ticks, leaf miners, and leaf-hoppers. • It is also used for treating domestic animals to control internal parasites. • Lice of fish. Precautions : Do not feed the animal for a certain time before and after applying powder. During applying powder, Cover the animal’s mouth. (Trichlorfon powder is poisonous). Pulv. Negovet Each gram Hump sore: Applied 5 gm 10 gm, Bridge powder contains powder with oil to the infection 20 gm Trichlorfon USP area 2 times daily for 3-5 days. sachet 1.00 gm. For ticks, mites, lice & fleas: Add (100 %) 2 gm powder to 1-liter water & mix well, then slowly spray on the body and repeat the same after 21 days. Pulv. Negotox Do Do Do CHEMIST Pulv. Ticofon Do For external application only. 10 gm Acme vet For Humpsore: Add 10 g powder to 0.5 liter lukewarm water & mix well, then wash the affected area and dry well by sponge/ clean cloth or 10 g powder mix with 10 g Vaseline then administer twice daily for 3-5 days to the affected area. For tick, mite, lice & flea: Add 2 g powder to 1 liter water & mix well, then slowly spray on the body or wet the clean cloth with mixed solution & wash the body. Repeat the same after 21 days. Do Pulv. Netrofon Do 10 gm, Super Vet 20 gm, power 100 gm, Pulv. Nagavon Do Do 20 gm ALBION Plus (Vet) sachet Metrifonate Indication: Biting and sucking lice, mange mites, fleas, flies, red avian mites (Dermanyssus avium, Dermanyssus gallinae), scaly leg mites (Cnemidocoptes mutans), skin larvae of Hypoderma bovis, Hypoderma lineatum, Dermatobia hominis, stomach bots (Gasterophilus spp.), tick and roundworms (Hump sore). 56 Use in Pregnancy and Lactation: Powder has not been shown to produce reproductive or teratogenic effects. But, do not administer to lactating dairy cows. Adverse effects: No adverse effects are expected if this product is used in accordance with the label. Some symptoms of overexposure that can arise are: blurred vision, weakness, giddiness, sweating, muscular twitching, spasms, miosis and respiratory paralysis. Can be absorbed through skin. May irritate the skin. May irritate the eyes as well. Pulv. Ectonil Each gram Cattle, pig, horse, sheep and 10 gm SQUARE Vet powder contains goat: Wash or spray treatment sachet Metrifonate USP of the whole animal; repeat (Trichlorfon) 1.00 after 5 days. gm. Concentration: 0.15% solution (1.5 gm per liter of water). Oral administration: 50-75 mg/kg body weight. Cypermethrin Characteristics: New synthetic pyrethroid insecticides. ✓ Cypermethrin is a new synthetic pyrethroid. Cypermethrin acts on the nervous system of insect. It appears that the compounds interact with nerve membranes, blocking ion channels, and so preventing normal conduction of the nervous impulse. The sensory nervous system is probably one of the first sites affected. ✓ The lipophilic property of the compound means that it penertrates quickly to the site of action in quick knockdown. ✓ Cypermethrin has various properties as the followings; 1. High level of activity at low concentrations. 2. Broad spectrum of ectoparasites which attack livestock. 3. Stable to ultra-violet light. 4. Low toxicity to warm-blooded animals. ব্যব্হার ক্ষেত্রঃ ✓ গরু-মহিষ, ছাগল-ভেডা, কুকুর, শূকর ইত্যাহি প্রাহি Lice (উকুন বা এঁটেল ভ াকা), Ticks (রক্তটশাষক কীে বা রজীহব) এবং Mites (অহত্ ক্ষুদ্র কীে যািা চমটরাগ ম সৃষ্টি কটর) কীে দ্বারা প্রায়শ আক্রান্ত িটয় থাটক। যার ফটল চমটরাগসি ম নানা প্রকার মারাত্মক ভরাগ প্রাহিটত্ ভিখা ভিয়। এসব কীে হনয়ন্ত্রি ও িমটন বযবহৃত্ িয় ✓ মশা, মাহছ হনয়ন্ত্রি ও িমটন বযবিার করা িয়। Lice, Ticks এব্ং Mites দ্বারা আক্রান্ত Emulsion: Each 100 ml 100 ml, 500 Super হলে- ১০ হম.হল. L.T.M. KILLER ১৮ হলোর L.T.M Killer-EC contains ml, power াহনর সাটথ হমহশটয় সারা শরীর ভ ৌত্ Cypermethrin 1 L bottle করটত্ িটব। ১-২ ঘন্টা র হরষ্কার াহন USP 20 gm হিটয় ুিরায় সারা শরীর ুটয় ভফলটত্ িটব। ঔষ শরীটর লাগাটনার ূটব ম গবাহিপ্রাহির মুখ িালকা োটব ভবট হনটল োল িয়। মাছি ছিয়ন্ত্রলে- ৫০হম.হল. L.T.M. KILLER ১০ হলোর াহনর সাটথ হমহশটয় ভিয়াল ও হসহলং বা মাচায় ভে করটত্ িটব। মশা ছিয়ন্ত্রলে- ২৫হম.হল. L.T.M. KILLER ১০ হলোর াহনর সাটথ হমহশটয় ভিয়াল ও হসহলং বা মাচায় ভে করটত্ িটব। Soln. Superkiller-E Do After adding Superkiller-E to fresh water and stir well, spray wall and ceiling with it (Do not store the diluted suspension). House flies: 50 mL per 10L of water. 1 litter, 4 litter container PHARMA & FIRM 57 Oint. DressgelFR vet (Herbal Antiseptic & Fly Repellent Ointment) Mosquitos: 25 mL per 10L of water. Ticks (Mites): 15 mL per 18L of water. Dipping application for prevention: 37.5 mL per 250L of water. Each 50 gm contains, Nim oil (Azadirachta indica)- 5.0 g (It is herbs tonic that reduce inflammations. It has antiseptic properties, destroys insects & parasitic organisms.) Marigold oil (Tagetes eracta)- 1.0 g (It is natural phytochemical that remains sulphar containing ring & which destroy gram positive & gram negative organisms.) Mustard oil (Brassica campestris)- 10.0 g (It acts as a disinfectant. It heals skin laceration & inflammations.) Dedaru oil (Cedrus deodara)- 1.0 g (It is used as insect repellent. It also has astringent & antifungal properties.) Halud (Curcuma longa)- 5.0 g (It has antifungal & antibacterial properties.) Mongistha (Rubia cordifolia)- 2.0 g (It promotes the healing of skin tissue damaged by injury or infections.) Indications: Dressgel-FR acts as a broad-spectrum antiseptic and fly repellent agent. It is used in complexity of infections, Humpsore, Footrot, Manz, sore from FMD & all types of burns and wounds. Dosage & Administration: Clean the affected part and apply the Dressgel-FR twice a day. 50 gm tube ACME Antimony preparation Generic dose of Lithium Antimony Thiomalate- 1.2-2.2 mg/kg, IM/SC. Trade Composition Trade dose name Inj. Each ml contains Administer by deep intramuscular Anthiomat Lithium Antimony route preferably at the gluteal Thiomalate Equivalent muscles. to 12 mg Antimony Nasala Granuloma: 15 ml to 20 ml Trioxide-- (6% w/v) on three occasions at weekly Chlorocresol (as intervals. preservative)—(0.1% Papillomatosis: 15 ml to 20 ml on w/v) 4-6 occasions on alternative days. As warts necrose, they should be enucleated and suitably dressed Vial size 50 ml Company TECHNO 58 Filariasis and Leishmaniasis in canines: 1 ml to 2.5 on 4-6 occasions on alternate days. The dosage may be gradually increased. Indications: Anthiomat is the drug of choice for treatment of Nasal granuloma. (Schistosomiasis) and Papilomatosis in large animals, filariasis and lelishmaniasis in canines. Pregnancy & Lactation: This drug can be used during pregnancy & lactation. Antiprotozoal drugs Imidocarb dipropionate Mode of action: Imidocarb is thought to act by combining with nucleic acids of DNA in susceptible organisms, causing the DNA to unwind and denature. This damage to DNA is believed to inhibit cellular repair and replication. Indication: Babesiosis (mainly), Anaplasmosis, Ehrlichiosis Generic dose: Ruminant: 1-3 mg/kg BW, deep IM; repeat in 10–14 days. Horse: 2-4 mg/kg deep IM at 72 hour intervals for 4 doses. Toxicity: The sign of acute toxicity is generally consistent with anticholinesterase activity of Imidocarb Dipropionate and included lethargy, salivation, lacrimation, ataxia, tremors and convulsions. Precaution: Intravenous administration is totally prohibited. Contraindications: Animals hypersensitive to Imidocarb Dipropionate & having impaired lung, liver & kidney function. Use in Pregnancy: The safety and effectiveness of Imidocarb have not been determined in breeding, lactating or pregnant animals. Trade name Composition Trade dose Pack size Company Inj. Ectorid Each mL contains 1 ml/ 31 kg BW deep IM/SC 10 ml RENATA Imidocarb Dipropionate- 133.26 (as 3 mg/kg BW) mg (Equivalent to 93.5 mg Imidocarb base) Inj. Babenil Do Do 2 ml, TECHNO 10 ml vial Inj. Babecure Each ml injectable 1 ml/ 40 kg BW deep IM/SC 2 ml ACME solution contains (as 3 mg/kg BW) ampoule Imidocarb Very severely affected cattle Dipropionate INN 120 may require a second dose mg after 24 hours. Inj. E-Carbzol Each ml E-Carbzol IM/ SC injection 100 ml ACI contains 1) Treatment of babesiosis Vial Imidocarb cattle, sheep, goat : 1 ml per dipropionate-120 mg, 100 kg BW Methyl Horse : 2 ml per 100 kg BW parahydroxybenzoate 2) Prevention of babesiosis 0.45 mg, cattle, sheep, goat : 2.5 ml per Propyl 100 kg BW parahydroxybenzoate Horse: 2 ml per 100 kg BW 0.05 mg. 3) Treatment of Anaplasmosis or complication with babesiosis 59 cattle : 2.5 ml per 100 kg BW Diminazine aceturate Mode of action: Diminazene’s exact mechanism of action is not well understood. With Babesia, it is thought to interfere with aerobic glycolysis and DNA synthesis. Diminazene may not completely eradicate the organism but because it is slowly metabolized, suppression of recurrence of clinical signs or prophylaxis can be attained for several weeks after a single dose. ✓ Phenazone is active against fever especially in cases of Babesiosis. Indication: Babesiosis, Trypanosomiasis, Theileriosis, Anaplasmosis. Generic dose: Horses, cattle, sheep, goats: In general, 3.5 mg/kg IM one time. Depending on susceptibility, dose can be increased to 8 mg/kg. Do not exceed 4 grams total dose per animal. Use in Pregnancy and Lactation: No adverse effect has been reported at recommended dose. Trade name Composition Trade dose Pack Company size Inj. Berenil Each ml contains: Deep intramuscular or 20 ml, INTERVET Vet 7% RTU Diminazene aceturate- 70 subcutaneous at the side 30 ml, mg of the neck. 90 ml Phenazone BP: 375.0 mg Water for injection q.s. to 1 1 ml/ 20 kg, repeat often ml 24hrs Inj. BabcopDo Do 20 ml SQUARE Vet vial Inj. Diminal Each 1 g contain Do 2.36 g, Eagle Vet. Diminazene diaceturateOr Tech 445 mg 23.6 g (Imported Phenazone- 555 mg by ACI) DIMINAL ✓ To prepare the injection solution ready for use, the contents of a bag of 23.6g DIMINAL are dissolved in 150 ml water for injection and the contents of a bag of 2.36g DIMINAL are dissolve in 15 ml water for injection. Buparvaquone Description: Buparvaquone is a second-generation hydroxynaphtaquinone used for the therapy and prophylaxis of all forms of Theileriosis. It is active against both the schizont and piroplasm stages of Theileria spp., and can be used during the incubation period or when clinical signs are present. Indications: Theileriosis is a tick-transmitted disease, caused by the intracellular protozoan parasites Theileria parva (East Coast fever, Corridor disease, Zimbabwean Theileriosis) and T. annulata (tropical Theileriosis) in Cattle. Generic dose: 2.5 mg / kg BW, IM, q48h. Side Effects : Localized, painless, oedematous swelling may occasionally be seen at the injection site. Trade name Composition Trade Dose Vial size Company Inj. Albu-Vet Each ml solution contains 1 ml per 20 kg BW, IM, 50 ml vial AlBuparvaquone BP 50 mg. Treatment should be Madina repeated after 48 – 72 hours. Inj. Butec Do Do 10 ml Techno Inj. Buparvet Do Do 10 ml Bridge 50 ml 60 Anticoccidial agents Amprolium Chemistry: Amprolium is an analog of thiamine, and is a quaternary compound. Mode of action: By mimicking its structure, amprolium competitively inhibits thiamine utilization by the parasite. Prolonged high dosages can cause thiamine deficiency in the host; excessive thiamine in the diet can reduce or reverse the anticoccidial activity of the drug. Amprolium is thought to act primarily upon the first generation schizont in the cells of the intestinal wall, preventing differentiation of the metrozoites. It may suppress the sexual stages and sporulation of the oocysts. Therapeutic uses: Amprolium is the only anticoccidial agent that can be used in laying birds and cattle for both the prevention and treatment of outbreaks. Species Dose Route Interval Cattle 10 mg/kg PO SID, For 5 days 5 mg/kg PO SID, for 21 days as prophylaxis Sheep, goats Lambs: 55 mg/kg PO SID, for 19 days Swine 25–65 mg/kg PO once or twice daily for 3–4 days Precaution: Prolonged high dosages may cause thiamine deficiency; treatment is usually no longer than 14 days. Drug Interaction: It is better not to use with Furazolidone. Amprolium and Furazolidone both are antagonized the utilization of thiamin. In this regards using both simultaneously may deficit thiamin in the system. Trade name Composition Trade Dose Pack size Company Cattle: 1 mL/20 Kg (10 20 ml mg/Kg) body weight 100 ml for 5 days 500 ml Sheep & Goat: 55 mg/Kg body weight, daily for 19 days Swine: 25-65 mg/Kg Each mL solution contains body weight, once or Amprolium Hydrochloride 200 twice daily for 3-4 mg. days Soln. Amprol L SK+F Dogs: 200-300 mg (Small puppies- 60100 mg)/animal, daily for 7-12 days Cats: 60-100 mg/animal, daily for 7 days Rabbit: 100 mg/7 Kg body weight, daily for 5 days Each 100 gm Powder contains For cattle, Baffalo, 100 gm, Amprolium Hydrochloride USP goat, sheep and 500 gm Pulv. Remecox 17.0 gm calves: 1 gm per 50 kg Bengal Vet Sulphaquinoxaline Sodium USP body for 5-7 days. 17.0 gm Vitamin K BP—0.10 gm 61 Pulv. Amprol EP Pulv. Coctreat-EP Each gm contains Amprolium hydrochloride- 100 mg Ethopabate BP- 5 mg Sulphaquinoxaline USP- 60 mg Vit K3- 2 mg Vit C- 20 mg Do 1 gm/ 10 kg BW, PO for 5-7 days. Do 6 gm, 100 gm pack SK+F 100 gm Square Toltrazuril Mode of action: Toltrazuril is the parent compound to ponazuril (toltrazuril sulfone). Its mechanism of action is not well understood, but it appears to inhibit protozoal enzyme systems. Toltrazuril has activity against Hepatozoon, Isospora, Sarcocystis, Toxoplasma, and all intracellular stages of coccidia. Generic dose: SHEEP- For ovine coccidiosis (Eimeria ovinoidalis)–20 mg/kg PO once. Use in Pregnancy and Lactation: No reproductive or nursing safety information was located. Trade name Composition Trade Dose Pack size Company Each ml solution contains Calves, Sheep, Goats Toltrazuril INN 25 mg. & Pigs: 0.8 ml (20 mg) per kg Soln. Toltacox 100 ml, body weight for 2 Incepta Vet 500 ml consecutive days. If necessary, repeat after 5 days. Soln. Xmeria Do Do 100 ml SK+F n Sol . Anticoc Do Do Do Acme Soln . Coxitril Do Do Do Square Vet Soln. Tolicox Do Do Do Popular Autacoids Antihistaminic Indications: ✓ Histamine mediated adverse effects. ✓ Allergic conditions: Urticaria, pruritus, drug allergy, anaphylaxis ✓ Inducing sedation (Promethazine and diphenhydramine) ✓ Prevention of motion sickness, compulsive scratching, ✓ Rhinitis, pulmonary oedema, local anaesthesia ✓ Bronchospasm, puerperal toxaemia, nausea, vomiting ✓ Insect bite, serum sickness, moist eczema etc. Adverse effects: ✓ CNS depression: Lethargy, somnolence, ataxia ✓ Antimuscarinic effects: Dry mouth, urinary retention ✓ High doses: CNS stimulation is possible (Pyrilamine in the horse) ✓ Some individuals: Allergy to the use of Hi-antihsitamines Use in Pregnancy & Lactation: Safety during pregnancy has not been established. Pheniramine maleate (moderately-sedative, H-1 blocker) Mode of action: Pheniramine maleate binds with H1 receptor and Stop histamine release. 62 Generic dose: Large animal: 0.5-1 mg/Kg BW, IM/IV. Small animal: 1-2 mg /kg BW, IM/IV. Trade name Composition Inj. Antihista vet Each ml injectable solution contains Pheniramine Maleate BP 22.75 mg Inj. Histavet Inj. Astavet Inj. Niravet Inj. Alarvet Inj. Alerin Inj. Asta vet Do Do Do Do Do Do Trade dose IM & IV route Cattle, Buffalo & Horse: 5-10 ml per day (total dose) Goat & Sheep: 0.5-1 ml per day (total dose) Onset of action is quick following IV administration and acts within 10-20 minutes after IM administration. The drug can be administered 2-3 times daily, depending on the severity of the disease. Do Do Do Do Do Do Pack size 10 ml 100 ml vial Company Do Do Do Do Do Do ACI ACME OPSONIN POPULAR SK+F Acme SQUARE Chlorpheniramine maleate (1st generation, mild-sedative, H-1 blocker) Mode of action: Chlorpheniramine maleate binds with H1 receptor and stop histamine release. Generic dose: Ruminants, Horse, Pig: 0.4-0.5 mg/kg BW, IM. Trade name Composition Trade dose Pack size Company Inj. Histacin vet Each ml injectable 1 ml/20 kg BW IM/IV, 10 ml, Jayson solution contains q24h. 100 ml Chlorpheniramine maleate: 10 mg (as 0.5 mg/kg) Inj. Renacin vet Do Do Do Renata Inj. Fenarvet Do Do Do Techno Diphenhydramine st (1 generation, highly-sedative, H-1 blocker) Mode of action: diphenhydramine binds with H1 receptor and Stops histamine release. Generic dose: Cattle: 0.5–1 mg/kg BW IV/IM. Horse: 0.25-1 mg/kg BW, IM/IV. Trade name Composition Trade dose Pack size Inj Phenadryl Diphenhydramine 1 ml/ 20 kg BW IM/IV 10 ml, vet Hydrochloride – 20 30 ml mg/ml (as 1 mg/kg) vial Company ACME Promethazine st (1 generation, highly-sedative, H-1 blocker) Mode of action: Promethazine binds with H1 receptor and Stops histamine release. Indication: It is effective in anaphylactic reactions and in many allergic disorders including- 63 Allergic dermatoses, Eczema, Urticaria, Allergic rhinitis, Anaphylactic shock, Serum sickness, Gaseous bloat, Laminitis Insect bite. It has a great value when administered along with the specific therapy against- Mastitis, Metritis, Prolapse of the uterus, Milk fever Generic dose: Ruminants: 0.5-1 mg/kg BW, IM/IV/PO. Horse: 0.4—1 mg/kg, IM/IV. Use in Pregnancy & Lactation: Not safe. Trade name Composition Trade dose Pack size Company Inj. Dellergen Each ml contains: Cattle, Buffaloes & Horse: 3-4 10 ml RENATA Promethazine ml per 100 kg body weight, hydrochloride USP 50 IM. mg. Sheep & Goat: 0.5-2.5 ml per 10 kg body weight, IM. Inj. Phenerax DO DO DO JAYSON vet Inj. Flugan DO DO DO TECHNO Inj. Promodin DO DO DO CHEMIST vet Bol. Dellergen Each bolus contains: 1 bolus/ 100 kg body weight 150 mg RENATA vet Promethazine 3-5 days bolus hydrochloride 150 mg. Bol. Prom-AL DO DO DO Albion vet Bol. Prozin Vet DO DO DO ACI Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Mode of action: Inhibit cyclooxygenase enzyme to prevent prostaglandin synthesis which is a mediator of inflammation. Indications: Treatment of pain, pyrexia and inflammation. ✓ Musculoskeletal disorders: Arthritis, laminitis, tendonitis, myositis. ✓ Pain: headache, earache, body ache, neuralgia, pain due to intestinal inflammation rheumatoid fever, post vaccination pain, post-delivery pain, post-operative pain. ✓ Tissue swollen resulting from trauma, injury, burn or any other infectious diseases. Precautions: Do not administer concurrently with steroidal anti-inflammatory drugs (SAID) & other non-steroidal anti-inflammatory drugs (NSAID). Paracetamol (Weak NSAID) Generic dose: Calf: 50 mg/kg PO followed by 30 mg/kg bwt PO 6h. Contraindication: Contraindicated in Cat, dog, hepatic and renal insufficiency. Use in Pregnancy and Lactation: is safe in all stages of pregnancy and lactation. Trade name Composition Trade dose Pack size Bol. Fast vet Each Bolus Cattle: 1 bolus/130-140 kg body 2 gm contains weight 3 times daily. bolus Paracetamol BP 2 g. (as 15 mg/kg BW) Tab. Pyralgin DO DO DO vet Bol. Ace vet DO DO DO Company ACME RENATA SQUARE 64 Bol. P-tamol vet Bol. Remedy Vet Bol. Paracetamol Bol. Para-AL (Vet) DO DO DO NAVANA DO DO DO Bengal DO DO DO Bridge DO 1 bolus/100 kg body weight, 3 times daily. DO Albion Meloxicam (Strong NSAID) Generic dose: Species Dose Route Interval Cattle 0.5 mg/kg BW SC or IV 24 h Horse 0.6 mg/kg BW IV 24 h Swine 0.4 mg/kg BW IM 24 h Contraindications: • Animals less than six weeks old. • Animals hypersensitive to Meloxicam. • Contraindicated in animals with impaired renal, Hepatic or cardiac function. Use in Pregnancy and Lactation: Meloxicam is not recommended for use in pregnant, lactating. Trade name Composition Trade dose Pack Company size Inj. Camlox Each ml contains Cattle, Goat, Sheep, Horse: 1 10 ml, Popular Vet Meloxicam BP 5 mg ml per 10 kg body weight 30 ml SC/IV/IM as a single dose vial (as 0.5 mg/kg) Inj. Melvet DO DO DO ACME Inj. Melovet DO DO DO Techno Inj. Loxikam DO DO DO OPSONIN Inj. M-Pain DO DO DO ACI Vet Inj. Melocam DO DO DO RENATA Vet Inj. Mel-Vet Each ml contains For IM/IV/SC administration. 10 ml ACME plus Meloxicam BP 20 mg Livestock: 1 ml / 40 kg body vial Paracetamol BP 150 weight as a single dose. Or 0.5 mg. mg/kg body weight as a single dose. Inj. Loxikam DO DO DO Opsonin plus Inj. Action 3 DO DO DO Incepta vet Bolus Bol. Mel-vet Each bolus contains Cattle: 1 bolus/100 kg body 100 mg ACME Meloxicam BP 100 mg. weight orally single dose. bolus (as 1 mg/kg) Pig: After subcutaneous injection, 0.1 mg/kg orally daily for 2 weeks. Bol. Loxikam DO DO DO OPSONIN 65 Bol. M-Pain Vet Tab. Melvet plus DO DO DO ACI Each bolus contains Meloxicam BP 100 mg & Paracetamol BP 1500 mg. Large Animal: 1 bolus/200 kg body weight, PO, daily. Small Animal: ¼ – ½ bolus, PO, daily. 100 mg + 1500 mg bolus Acme Tolfenamic acid (Strong NSAID) Indication: is highly effective anti-inflammatory, antitoxic, analgesic & antipyretic associated with respiratory diseases, acute mastitis, mastitis-metritis-agalactia syndrome, musculoskeletal pain etc. in animals. It is also indicated as supportive therapy with antibiotic Generic dose: 2-4 mg/kg bwt, IM/IV/SC Contraindication: Tolfenamic acid is contraindicated in animals hypersensitive to it or to other drugs in its class. It should not be used in animals with active Gl ulceration. Warning & Precaution: Tolfenamic acid decreases thromboxane activity & platelet function. So, it is not recommended for using pre-surgically. It should be used cautiously during weak kidney and liver function. Use in pregnancy and lactation: Tolfenamic acid may be used during pregnancy and lactation. Trade name Composition Trade dose Vial Company size Inj. Tamic Vet Tolfenamic Acid: 40 For IM/SC/IV injection only 10 ml, Acme mg/ml Livestock: 30 ml Pneumonia- 1 ml/20 kg body vial weight Acute Mastitis- 1 ml/10 kg body weight by IM at neck musculature or slowly at IV. Repeat once only after 48 hours if required. Pig: 1 ml/20 kg body weight as a single IM injection in the neck musculature. Inj. Tolfavet DO DO DO TECHNO Inj. Tufnil Vet DO DO DO SK+F Inj. Fevenil DO DO 10 ml RENATA Inj. Set 101 Vet DO DO DO Incepta Inj. Tolfamin DO 50 ml GENTRY Bol. Tamic Vet200 Each bolus contain Tolfenamic Acid 200 mg 200 mg bolus Acme Bol. Tufnil vet Bol. Tolfavet DO DO 1 ml per 20 kg body weight by IM or SC with 48 hours intervals. Bolus 1 bolus/ 100 kg body weight. It can be administered directly into the mouth of the animals, either by dissolving the bolus in water and given as a drench or by mixing with any feed. DO DO DO DO SK+F TECHNO 66 Flunixin Meglumine (Strong NSAID) Indications: is indicated for rapid relief of Pain, Inflammation & Fever in the following conditions: Bovine Respiratory Disease (BRD), Endotoxemia, Mastitis, Metritis, Muscular fatigue, Lameness, Arthritis & Gout. Generic dose: Species Dose Route Interval Cattle 1.1–2.2 mg/kg IV 6– 12 hours Sheep, goats 1–2 mg/kg IV 24h 1–4 mg/kg PO 24 h Horses 0.5–1.1 mg/kg IV/IM/PO 8–12 h Swine 2.2 mg/kg IM once Precautions: Flunixin should not be used in animals with active GI bleeding or ulceration. NSAIDs should be avoided or every carefully monitored in animals in animals with liver or kidney disease. Use in Pregnancy: Flunixin can be used during pregnancy. Trade name Composition Trade dose Vial size Company Inj. Pif R vet Flunixin Meglumine: Cattle, Buffalo: 2 mL/45 kg body 10 ml, SK+F 50 mg/ml weight IM/ IV once daily for 3 30 ml days. vial Horse: 1 mL/45 kg body weight IM/ IV once daily for 5 days. Inj. Meglunix Do Do Do Popular Vet Inj. Fixin Vet Do Do Do ACI Inj. Lega Vet Do Do Do Acme Inj. FM vet Do Do 10 ml Techno Metamizole (Strong NSAID) (Synonyms: Sulpyrine, Dipyron hydrate, Dipyrone monohydrate, Metamizole sodium hydrate) Generic dose: 40 — 50 mg/kg bwt, SC/IM/IV/IP. Contraindication: Aspirin induced asthma, lactation and late pregnancy. Trade name Composition Trade dose Pack Company size Inj. D-Pron Each 1 ml contains Inject the following dosage 1—3 50 ml GENTRY Sulpyrine- 400 mg times a day intravenously, Special agents ... q.s. intramuscularly or subcutaneously Large animal (Cattle, Horse): 5— 10 ml Medium animal (Pig, Sheep, Goat): 2—5 ml Small animal (Dog, Cat): 0.5—2 ml Description: D-PRON INJ. Which has analgesic, antipyretic and antispasmodic properties as one of Pyrazolone derivatives, shows stronger antipyretic effect about three times than that of antipyrine and has a powerful analgesic and antiphlogistic actions. D-PRON INJ. Has continuous antifebrile process and prominent allaying effect against convulsion of smooth muscle. It hardly ever shows side effects and it has a low toxicity. 67 Carprofen (Mild to moderate NSAID) Indications & usage: PK 5 Vet is indicated for rapid relief of Pain, Inflammation & Fever in the following conditions — Bovine Respiratory Disease, Osteoarthritis, Mastitis, Metritis, Soft tissue surgical pain, Post-operative pain, Lameness Generic dose: Cattle: 1.4 mg/kg IV or SC once. Horse: 0.7 mg/kg IV, one time Reptiles: 1–4 mg/kg IV, IM, SC, PO q 24–72h Use in pregnancy: In the absence of any specific studies in pregnant cattle, use only according to the benefit/risk assessment of the responsible veterinarian. Side effects: There are relatively few side effects assorted with Carprofen. The most common side effects are diarrhea, vomiting & loss of appetite. Trade Name Composition Trade Dose Pack Company Size Inj. PK5 Each mL injection Cattle: 1 mL/35 Kg (1.4 mg/Kg) 10 ml SK+F contains Carprofen body weight IV/ SC injection once USP 50 mg. daily Horses: 1 mL/70 Kg (0.7 mg/Kg) body weight IV injection once daily Birds: 1 mL/12.5-50 Kg (1-4 mg/Kg) body weight IM/IV once daily Reptiles: 1 mL/12.5-50 Kg (1-4 mg/Kg) body weight IM/IV/SC once daily Bol. PK5 Each Bolus contains Cattle, Buffalo: 500 SK+F Carprofen BP 500 1 bolus/350 kg body weight once mg mg. daily bolus Or 1.4 mg/kg body weight once daily Horse: 0.7 mg/kg body weight once daily Reptiles: 1-4 mg/Kg body weight once daily Others Trade name Pulv. Renaspirin Composition and Trade dose Carbasalate Calcium BP 76.32 gm (Equivalent to 60 g of Acetylsalicylic acid) and Sodium Ascorbate USP 7.48 gm (Equivalent to 6.65g of Ascorbic acid) Trade dose: Vial size Company 10 gm, 50 gm sachet Renata 68 Indication: Renaspirin is indicated for antipyretic, analgesic and anti-inammatory effect on Horses, Calves, Lambs, Swine, Dog. Pulv. BcoxComposition: same as Renaspirin 10 gm Square Vet Dosage & Administration: Cattle: 3-8 gm/50-150 kg BW per liter of drinking water for 2-3 consecutive days. Inj. Each ml contains- Aminopyrine-50 mg, 100 ml Gentry HD-Pyrine Sulpyrine-50 mg, Chlorpheniramine Maleate-1 mg Dosage & Administration: Cattle, Horse: 10-20 ml. Calf, Sheep: 3-5 ml. HD-Pyrine indications: Antihistamine, Antipyretic, Analgesic and Anti-inflammatory agent. Inj. TD Pyrin Do Do Techno Steroidal Anti-inflammatory Drugs (SAIDs) or Glucocorticoids Dexamethasone Pharmacology: Dexamethasone, Steroidal Anti-Inflammatory Drugs (SAID), is a powerful antiinflammatory, Analgesic and anti allergic drugs. It stabilizes individual cells and their internal structure so that they do not release the substances which initiate or perpetuate the irritation, pain and swelling referred to as inflammation. Dexamethasone inhibits the synthesis of Prostaglandin (PG), Interleukin (IL) and Platelet Activating Factor (PAF) by inhibiting cycloxyginase & lipoxyginase pathway of inflammatory process. Generic dose: Cattle, Sheep, Pig, HorseAnti-inflammatory: 0.02—0.1 mg/kg (20-100 mcg/kg) IV/IM/SC/PO, SID. Shock: 1—2 mg/kg IV/IM, SID. Indications: Dexamethasone is highly effective in suppressing or preventing inflammation. Mastitis, endometritis, arthritis, laminitis, dermatitis, pneumonia, bronchitis, allergy, ketosis, shock (being hit by a car, attacked by another animal or usually slip & hypovolemic or surgical shock), Supportive therapy (Insect bite, snake bite, shipping fever, retention of placenta etc.), Induction of parturition, Immunosuppressive, Nervous system disorder, Blood calcium reduction, Cancer therapy etc. Common side effects: May suppress the immune system and muscular weakness may occur. Use in pregnancy & lactation: Abortion may occur in pregnant animal. Trade Name Composition Trade Dose Pack Company Size Inj. Steron Vet Each ml contains For intramuscular or intravenous 10 ml, ACME Dexamethasone use only. 30 ml Sodium Cattle: 2.5-10 mL (5-20 mg), vial Phosphate BP 2 (Total dose) mg. Sheep/Goat: 0.5-1 ml, (1-2 mg), (Total dose) Horse: 1.25-2.5 mL (2.5-5 mg), (Total dose) Calf: 0.5-1.5 mL, (Total dose) (Repeat as needed.) In case of shock dose should be 5 mg/kg IV. Inj. Dexavet Do Do 10 ml TECHNO 69 Inj. Dexaroid vet Inj. Remedex Vet Do Do Bol. Steron vet Each bolus contains Dexamethasone BP 10 mg. Do Bol. Vetodex Do Cattle & Horse: 2-10 ml/100 kg body wt. IM or IV. Sheep, Goat & Dog: 0.5-2.5 ml/25 kg body wt. IM or IV. Cattle: ½ —2 bolus (5-20 mg) daily. Horse: ½ —1 bolus (5-10 mg) daily. Do Do 10 ml, 50 ml SK+F Bengal 10 mg bolus ACME Do OPSONIN Pack Size 10 ml Company Dexamethasone + Prednisolone Trade Name Composition Inj. Predexanol S Each ml contains Dexamethasone Sodium Phosphate + Prednisolone : 2.5 mg + 7.5 mg Dose Cattle & Buffaloes: 4-8 ml per RENATA animal, IV/IM/SC, 2-5 days. Horses: 6-8 ml per animal, IV/IM, 2-5 days. Sheep: 5-10 ml, IM/SC. Predexanol-S is the combination of two potent and highly effective Gluco-corticoides i.e. Prednisolone & Dexamethasone. Prednisolone acts promptly but only for a short period, and Dexamethasone trimethylacetate, whose potent effect begin for a few hours but then persists for several days (up to 10 days). Predexanol-S is a unique and potent Gluco-corticoid formulation to promote gluconeogenesis and to reduce inflammation, allergic reaction or toxic manifestation. Indication: Cattle & Buffaloes-Primary and secondary Ketosis, Parturient paresis, Grass tetany, Indigestion, Acute laminitis arthritis, Tenosynovitis, Dermatitis Horses: Eczema, Acute laminitis arthritis, Chronic bronchitis with enlarged lung Sheep: Hepatic dystrophy associated with pregnancy Mucolytics, Expectorant and Brochodilator Indication: Coughing, any respiratory infection, sneezing, nasal discharge, Pneumonia, Asthma, cold, congestion of lungs. Trade name Composition Trade dose Vial size Company Liq. Each 100 ml contains Treatment: 100 ml, Acme Bronchovet Adhatoda vasica 16 g, Large animal- 0.5 ml/kg body 500 ml, Zingiber officinale 400 weight twice daily until 1L (Vitamin mg, recovery. enriched herbal Glycyrrhiza glabra 500 Small animals- 0.3 ml/kg cough syrup) mg, body weight twice daily until Ocimum sanctum 2 g, recovery. Vitamin E 50 mg, Prevention- 7 days/month. Vitamin B5 52 mg & sodium chloride 750 mg. Soln. DILORES Each 100 ml contains Large Animals: 30 ml twice 100 ml Acme VET Eucalyptus oil 20 ml, daily for 3- 5 days. 500 ml Mint oil 20 ml, Small Animals: 20 ml twice bottle. Thyme oil 20 ml, daily for 3- 5 days. Menthol 10 ml, 70 Camphor 2 ml, Ocimum sanctum 12 ml & Sorbitol 16 ml. Soln. Respiton Mint oil- 2% Cattle and Horse: 20-40 ml. 100 ml Popular Juniper oil- 2% Sheep and Goat: 5-10 ml. Rosemary oil- 2% Solution, diluted with at least Oregano Vulgare oil- 2% 1 Liter drinking water. Surfactants & stabilizersIn case of acute symptoms 15% dosage can be increased up Distilled water- 77% to 30 % of regular dosage. Soln. TD COUGH Each litre contains, 0.5 ml/L drinking water for 7 100 ml Techno Phenylbutazone BP 50 g days. 500 ml Bromhexine HCl 10 g Bol. Cold Care Each bolus contains Cattle: 0.5 mg/Kg or 1 Bolus / 100 mg SK+F Vet Bromhexine 200 Kg body weight, once daily bolus Hydrochloride BP 100 for 5 days mg. Horse: 0.20-0.40 mg/Kg or 1 Bolus/250-500 Kg body weight, once daily Pulv. Mucospel Each gram powder For oral administration in the 10 gm Square vet contains Bromhexine feed or drinking water. 20 gm Hydrochloride BP 10 mg. Cattle: 1 gm powder per 20 50 gm kg body weight (0.5 mg/kg 100 g body weight) once daily for 5 500 g days. Pigs: 0.20-0.50 g/ 10 kg body weight (0.20-0.50 mg/ kg body weight) once daily for 5 days. Indication: Mucospel-Vet powder is indicated for the treatment of respiratory disorders associated with viscid or excessive mucus or productive cough. This include: Tracheobronchitis, Bronchitic with emphysema, Bronchiectasis, Bronchitis with bronchospasm, chronic inflammatory pulmonary conditions, Pneumoconiosis. Pulv. A-COLD Do Do 100 gm Acme VET Generic dose of Aminophylline Horse: 2–7 mg/kg IV q6–12h Ruminant: 2-5 mg/kg, IV/IM, q12h. Indication: Bronchodilator drug with diuretic activity; used for bronchospasm & cardiogenic pulmonary edema Precauition: For Intravenous, aminophylline should be diluted in at least 100 mL of D5W or normal saline and administered slowly. Use in pregnancy & lactation: Not safe. Tab. Filin Aminophylline: 100 1 tab/ 50 kg BW, PO,Bid. 100 mg Opsonin mg/tablet. tablet (as 2 mg/kg) Inj. Filin Aminophylline: 25 mg/ml 1 ml/12.5 kg BW, IV/IM 5 ml Opsonin q12h. ampoule (as 2 mg/kg) Generic dose of Salbutamol (albuterol sulfate) 71 Uses/Indications: Albuterol is used principally in dogs and cats for its effects on bronchial smooth muscle to alleviate bronchospasm or cough. It is also used in horses as a bronchodilator. ✓ Inhalation preparation acts as aerosol: 1-2 puffs 4-8 hourly (100-200 µg/d) (duration of action: 4 hours) ✓ Orally as tablet 2-4 mg upto 4 times/ day. ✓ Use in pregnancy & lactation: Not safe. Syp.Brodil Salbutamol: 2 mg/5 ml 5-10 ml, PO, 4 times/ day. 100 ml ACI Tab. Brodil Each tablet contain 1 tab PO, 4 times/ day. 2 mg/4 ACI Salbutamol: 2 mg or 4 mg mg tablet Nebulization Respiratory Solution: Sultolin Salbutamol: 5 mg/ml Inhaler: Brodil HFA Salbutamol: 100 mcg/ puff Salbutamol mix wth Distilled water/NS at 1:3 ratio. Sig: 1 ml sultolin mix with 3 ml NS, then nebulize twice daily for 2-3 days. 1-2 puffs 4-8 hourly 20 ml Square ACI Diuretics Diuretics are drugs that increase urinary loss of sodium ions (Na+) and water. By shrinking extracellular fluid (ECF) volume, they mobilize edema fluid from the interstitial space and restore normal tissue perfusion and organ function. Their primary clinical use in veterinary medicine is in the prevention and treatment of generalized edema or severe local edema. Causes of generalized edema include congestive heart failure, liver disease, renal disease, or protein-losing enteropathies. The latter three conditions are characterized by low levels of plasma albumin because of the impaired synthesis (liver disease) or excess loss (renal or intestinal disease). The resulting fall in plasma oncotic pressure results in transudation of fluid from plasma to the interstitial space. Cerebral, pulmonary, ocular, and udder edema are examples of local edema that arises from infection, inflammation, trauma, or poisons. Frusemide Indications: Indicated for the treatment of ascites, udder edema, pulmonary congestion, renal failure, acute non-inflammatory tissue edema etc. It also helps to excrete poisons or drug overdose by increasing urine flow. Pharmacology: Furosemide increase urine volume by reducing the efficiency of sodium resorbing processes and so increase water loss from the body. Drug Species Dose Route Interval Frusemide/ Cattle 2.2–4.4 mg/kg IV 12 h 72 Furosemide Horse 1–2 mg/kg IM / IV 6–12 h Contraindication: Renal failure, Dehydration, Hepatic cirrhosis. Use in pregnancy & lactation: Not safe. Animal studies have shown an adverse effect on the fetus. Trade name Composition Trade dose Vial size Company Human preparation Inj. Fusid Frusemide- 10 mg/ml 2 ml / 40-80 kg BW, 2 ml Square IV/IM. ampoule Inj. Lasix Do Do Do Synovia Inj. G Frusemide Do Do Do Gonoshasthaya Tab. Fusid Frusemide- 40 1 tab/ 40-80 kg 40 mg Square mg/tablet BW,PO. Tab. Lasix Do Do Do Synovia Tab. G Frusemide Do Do Do Gonoshasthaya Veterinary preparation Bol. Edecure vet Each bolus contains For oral 5x4 Boli in Acme Furosemide BP 2 g. administration only. blister strip. Cattle: 1 bolus/ animal once daily. The bolus may be administered orally directly or through mixing with required amount of feed/water by grinding the bolus. Pulv. Nefguard Vet Each gram contains For oral 100 g Acme Methenamine-950 mg, administration only. Sachet (Nephromodulator) Thiamine hydrochloride (B1) 8 Livestock- 1 g/10 kg mg, body weight daily for Riboflavin BP (B2)- 1 7 days. mg Menadione sodium bisulfate (K3)- 2 mg. Indication of Nefguard Vet-is indicated in cases of urinary tract infections (such as- nephritis, cystitis etc.) and effective as a preventive in cases of ascites, gout, pharmacological poisoning, gumboro etc.in poultry. Mannitol Uses/Indications: Mannitol is used to promote diuresis in acute oliguric renal failure, reduce intraocular and intracerebral pressures, enhance urinary excretion of some toxins, (e.g., aspirin, some barbiturates, bromides, ethylene glycol) and, in conjunction with other diuretics, to rapidly reduce edema or ascites when appropriate. Mode of action: After intravenous administration, mannitol is freely filtered at the glomerulus and poorly reabsorbed in the tubule. The increased osmotic pressure prevents water from being reabsorbed at the tubule. To be effective, there must be sufficient renal blood flow and filtration for mannitol to reach the tubules. Although water is proportionately excreted at a higher rate, sodium, other electrolytes, uric acid, and urea excretions are also enhanced. Drug Species Dose Route Interval Cattle, Goat, Sheep, Swine 1–3 g/kg IV Mannitol Horse 0.25–2.0 g/kg IV (20% solution) 73 Contraindication: Cardiac failure, Pulmonary congestion and edema, Haemorrhage Use in pregnancy & lactation: Not safe. Animal studies have shown an adverse effect on the fetus. Trade name Composition Trade dose Vial size Company Human preparation--IV infusion Inj. Manisol Each 100 ml contains 2 ml / 40-80 kg BW, IV. 500 ml Orion Mannitol- 20 gm (20%) bottle Inj. Osmosol Do Do Do Beximco Inj. Mannitol Do Do Do Opso saline Drugs used for digestive system disorders Appetizers Indication: ✓ To eliminate Anorexia, Indigestion and impaction, ✓ To increase milk & meat production, ✓ To ensure quicker fattening, ✓ To increase weight gain & immunity, ✓ To increase metabolism. ✓ To increase ruminal fermentation. ✓ To reduce anaemia. ✓ To increase hepatic function. ✓ After Antibiotic and anthelmintic treatment. Mode of action: ✓ Cobalt Sulphate is a precursor of vitamin B12 synthesis, and used in fortification of livestocks. ✓ Dried Ferrous Sulphate is required for the formation of R.B.C. ✓ Thiamin Mononitrate and Vitamin B12 helps in activation of various enzymes. ✓ Choline bitartrate helps in synthesis of Lecithin (a kind of phospholipid) in liver & also synthesis of acetylcholine. Use in Pregnancy & Lactation: Safe drug for use during pregnancy and lactation. Trade name Composition Trade dose Pack size Company Bol. Anora Each bolus contain Cattle & Buffalo: 2 Each box ACME Choline Bitartrate—9.1 mg boli/day orally for 2-3 contains Cobalt Sulfate—50 mg days 15 x 4’s Cyanocobalamin (b12)—20 Calf, Sheep & Goat: 1 boli in mcg bolus/day orally for 2blister Ferrous Sulphate—100 mg 3 days strips. Thiamine Mononitrate (B1)—25 mg Bol. Grumen vet DO DO Do SQUARE Tab. Anorexon DO DO DO Renata Bol. Roxyvet DO DO DO TECHNO Tab. Hozom vet DO DO DO ACI Bol. Hemorex DO DO DO ALMADINA Bol. Anora DS Each bolus containCattle & Buffalo: 1 Do Acme Vet Choline Bitartrate—18.2 mg boli/day orally for 2-3 Cobalt Sulfate—100 mg days Cyanocobalamin (b12)—40 Calf, Sheep & Goat: mcg half (1/2) bolus/day Ferrous Sulphate—200 mg orally for 2-3 days 74 Bol. Rexon DS Vet Tab. Anorexon DS Bol. Fatenin DS Bol. Faty DS Vet Bol. Rumix DS (Vet) Thiamine Mononitrate (B1)—50 mg DO Do Do SK+F Do Do Do RENATA DO DO DO DO DO Do DO DO DO OPSONIN POPULAR NAVANA Stomachic’s and Digestive stimulants Indication: treatment of ruminant animals suffering from indigestion, inappetence, anorexia, gastritis and ruminal impaction. Mode of action 1. Ammonium bicarbonate: During high temperature and in different stress conditions, animals suffer from loss of excess bicarbonate ion. Ammonium bicarbonate maintains the bicarbonate ion balance of the livestock. 2. Sodium bicarbonate: a. Sodium bicarbonate acts as an antacid and increases the gastric pH. As a result animals get rid of gastritis. b. If the formation of bicarbonate from the lactic acid by the carbohydrate metabolism delayed/ stopped, excess lactic acid is formed. Sodium bicarbonate helps in decreasing the excess acid. 3. Gentian powder: a. Gentian powder is an appetizer & helps in digestion. It also helps in mucous and bile secretion. b. It also act as carminative. 4. Ginger powder: a. Ginger powder helps against Dyspepsia, Flatulence & Colic. b. Helps in secretion of gastric juices. 5. Nuxvomica: Can be used against rheumatic diseases such as; Arthritis, Paralysis, sexual, nervous and mental weakness, etc. Contraindication: Administration of Atropine sulphate, Hyoscin, Butyle bromide, Loparamide can reduce its action. Use in pregnancy & lactation: safe. Trade Name Composition Trade Dose Pack Company Size Pulv. Stomaplex Each gram powder Cattle & Buffalo 20 gm SQUARE vet contains; For 100 – 300 kg BW: 1-2 sachet Ammonium sachets (20-40 gm) bicarbonate -250 mg For 301 – 500 kg BW: 3 Sodium bicarbonate — sachets (60 gm) 650 mg Calves, Sheep and Goats Nuxvomica — 70 mg For 15 – 25 kg BW: Gentian powder — 15 : ¼ - ½ sachet (5-10 gm) mg For 25 kg or above BW: ½ - 1 Ginger powder — 15 sachet (10 – 20 gm). mg Required quantity of drug should mix in 1-2 liter of 75 drinking water and apply twice daily for 2-3 days. Pulv. Digimax Pulv. Digitop Pulv. Digimix Pulv. Stoma vet Pulv Zymovet Pulv. Zymogen Pulv. Hazmi Vet Pulv. Remegest Vet Pulv. Ruchamax DO DO DO DO DO DO DO DO DO DO DO DO DO DO DO DO DO DO DO DO DO DO DO DO SK+F Novartis ACI RENATA ACME CHEMIST POPULAR Bengal 24 herbal plant, NaCl, CuSO4, FeSO4, NH4Cl Cows, Buffaloes and Horses: 15 g Calves, Heifers and Colts: 57.5 g Sheep and Goats: 3-5g Other animals-as per age and body weight The dose may be administered orally with Gur as a bolus or with molasses as electuary once or twice daily 15 gm, 30 gm sachet ACI Dose Cattle, buffalo: 2- 4 tab /day for 2-3 days. Goat / Sheep: ½ - 1 tab/ day for 2-3 days. DO DO Pack Size 5x4’s boli Company RENATA DO DO POPULAR Acme For Adult Cattle, Buffalo-2 bolus daily for 3-5 Days. DO DO AlMadina Albion Rumenotorics Indication: Ruminal stasis, indigestion. Trade Name Composition Tab. Each tablet contains, Rumenton Antimony potassium tartrate – 2 gm Dried Ferrus sulfate- 2 gm Tab. Motivet DO Tab. DO Rumigest vet Tab. Ferum DO Bol. Albenton vet DO DO Antizymotic & Digestive Stimulant Indication: Gastric and metabolic disorders in cattle, sheep and goats: Adjuvant treatment of acidosis, ketosis & pregnancy toxaemia, Overweight and sluggish rumen of the animals, Anorexia 76 due to sudden dietary changes, Bloat, Intoxications/ Poisoning (excess silage, urea etc.), Supportive treatment of traumatic reticulitis. Use in Pregnancy and Lactation: There is no evidence of embryotoxicity, fetotoxicity, teratogenicity or any harmful effects use in lactation period. Contraindication: Diarrhoea. Trade Name Composition Dose Pack Company Size Pulv. Bovicare Each g powder contains Treatment: 125 ACME Trachyspermum ammi-30 Adult Cattle, Buffalo: 125 gm mg, g twice daily for 3 days. sachet Calcium Carbonate -500 Calf: 60 g twice daily for 3 mg, days. Ginger- 25 mg, Sheep/Goat: 30 g once Cobalt Carbonate-0.11 daily for 3 days. mg, DL-Methionine-42.5 Prevention: 30-60 g once mg, Pyridoxine daily for 2-3 days Hydrochloride (B6) - 0.42 Powder should be mg. administered after mixing with ½ -1 L drinking water. Pulv. Bovivet Each g powder contains: DO 30 gm, POPULAR Calcium Propionate 504 125 mg gm Methionine 40 mg sachet Gentian 0.08 mg Cobalt Gluconate 0.32 mg Vitamin B6—0.32 mg Silicon Dioxide 12.8 mg Excipient (Dextrose) qs to 1g Pulv. Rumilator vet Do Do Do SK+F Pulv. Detox vet Do Do 125 Square gm sachet Pulv. Bovi 10 Do Do Do Albion Pulv. Bovi cure Do Do Do Navana Pulv. Bovi Plus Each g powder contains: Calcium propionate-500 mg DL-methionine—40 mg Pyridoxine—0.38 mg Gentian—80 mg Cobalt carbonate—0.1 mg Silicium dioxide—12.5 mg Dextrose—q.s to 124 mg Do + Oregano oil—6.4 mg Each Litre ContainsOregano oil-80,000 mg Do Do ACI Do Do ACI For all livestock: Administer in the drinking water at the dose of 1-2 100 ml Square Pulv. Vita Bovi Gold Oil. Orego Plus 77 (Immunostimulant, Antibacterial, Growth Enhancer & Antidiarrheal) Thyme oil-50,000 mg Tea ml per 10 Liter of drinking tree oil-20,000 mg water Anise oil-50,000 mg Total content in botanical essential oils-2,00,000 mg per Litre Indication: Acts as an immune booster because the botanical extracts in Orego Plus liquid have anti- oxidative capacity as well as some certain anti-bacterial, anti-fungal and anti-viral properties. Also they create positive influence on digestive enzymes by supporting the beneficial flora, enhancing the growth. Other benefits: - Increased feed and water intake due to aromatic taste — Stimulation of digestion — Optimized growth performance — Promotion of gut health, helping to reduce digestive disorders — Support of higher performance and feed efficiency Carminative Drugs for tympany & bloat Mode of Action: Simethicone: The Proven surfactant in the treatment of frothy bloat in cattle, sheep and goats Dill Oil: The time-tested carminative agent, which improves appetite and digestion and eases flatulence, constipation and hiccups. Trade Name Composition Dose Pack Size Company Emulsion. Bloat Each 100 ml contain – Cow / buffalo: 100 ml 100 ml ACME stop Vet Simethicon USP: 1 gm Goat / Sheep: 20 ml Dil oil: 0.5 ml It should be applied directly into the mouth or through the cannula or long needle into the rumen. Susp. No Bloat DO DO DO SQUARE Susp. Gasnil vet DO DO DO SK+F Susp. Zero Bloat DO DO DO Renata Susp. Lefoam Vet DO DO DO Incepta Susp. Bloatnil DO DO DO Navana Liq. Tympasan Each 100 ml contains: Cattle and buffalo: 40-50 100 ml ACI Trachyspermum amni Oilml daily 5 ml Calf: 25-30 ml daily Coriandrum sativum—5 g Sheep and goat: 15-20 Zingiber offcinalls—3 g ml daily Ferula Asafetida—2 g Black salt—5 g Edible Oil q.s Pulv. Rumen Plus Each gram powder Cattle, Buffalo: 1-2 20 gm TECHNO contains, packet for 100-300 kg sachet Cobalt sulphate-15 mg, body weight twice daily Dried ferrous sulphate-150 for 2-3 days. mg, Sheep, goat: 1 packet Vitamin B1-5 mg, /animal twice daily for 2vitamin B12-0.1 mg, 3 days. Nuxvomica -20 mg, zinger -140 mg, sodium bi-carboate – 669.9 mg. 78 Indication of Rumen PlusIs indicated for the cattle,Buffalo,sheep, goat like — Indigestion, Tympany / bloat, Anorexia, weakness, Beef fattening, After use of anthelmintic. Purgatives & Laxatives/ Intestinal stimulant Indications: For the treatment of constipation, acute carbohydrate engorgement, ruminal acidosis, bloat, simple indigestion, impaction & abomasal ulceration. Pharmacology : The osmotic force of Magnesium Hydroxide acts to draw fluids from the body and to retain those already within the lumen of the intestine, serving to distend the bowel, thus stimulating nerves within the colon wall, inducing peristalsis and resulting in evacuation of colonic contents. Magnesium Hydroxide acts as alkali to neutralize acid. Liquid paraffin acts as a stool lubricant. Use in pregnancy & lactation: In recommended dosage Magnesium Hydroxide do not have effect on pregnancy. However, risk & necessity should considered before administration Contraindications: Metabolic Alkalosis, Hyper-Magnesemia Trade Name Composition Dose Pack Size Company Emulsion. Each 5 ml contains Large Animal: 500 ml Acme Magvet plus Magnesium Hydroxide 0-1 year: 100-200 ml, 300 mg 1- 2 year: 200-300 ml: Liquid Paraffin- 1.25 ml. More than 2 year: 300500 ml. Shake well before each administration. Add 250 ml pure water to the required amount of emulsion and mix well before oral administration. Emulsion. Each ml contains DO DO ACI Mugsal Magnesium Hydroxide 60 mg Emulsion. Do Do 100 ml SK+F MagLax Vet 500 ml Drugs for acidosis Generic dose of sodium bicarbonate: 75 mg/kg BW, IV. Indications: sodium bicarbonate is an alkalinizing agent used to treat metabolic acidosis & alkalinize urine; may be used adjunctively for hypercalcemic or hyperkalemic crises. ✓ Metabolic acidosis ✓ Acute carbohydrate engorgement ✓ Severe primary lactic acidosis ✓ Barbiturate toxicity ✓ Severe diarrhea which is often accompanied by a significant loss of bicarbonate in body. Contraindications: Parenteral bicarbonate is generally contraindicated in patients with metabolic or respiratory alkalosis, excessive chloride loss secondary to vomiting or GI suction, at risk for development of diuretic-induced hypochloremic alkalosis, or with hypocalcemia where alkalosis may induce tetany. Use in Pregnancy and Lactation: Data is not available. Trade Name Composition Trade Dose Vial Size Company Inj. SB nate Vet Each ml contains Sodium 1.78—4.46 ml/kg body 100 ml ACME Bicarbonate BP 75 mg. weight or 100 ml/ 22-56 (7.5%) 79 Inj. Sobivet Inj. Sodicarb Pulv. Sodi-BiCarb DO Each ml contains Sodium Bicarbonate BP 84 mg. (8.4%) Sodium Bicarbonate 99% kg body weight; intravenously. DO 2-5 ml/kg body weight, IV 2-5 gm daily per cow PO, 3-5 days. DO 100 ml 250 ml bottle 1 kg packet Bridge Popular Agrovet Antidote Trade Name Susp. KOL Composition Activated charcoal: 16.4% Trade Dose Pack Size Company Cow, buffalo & horse: 500 ml Reneta 0.5-1 ml per kg body bottle weight. Calf, pig, sheep & goat: 1-2 ml per kg body weight. Repeat dose after 12 hours or as needed, in case of accidental poisoning double the dose & repeat after every 4-6 hours for 2448 hours. Liq. GI-TONE Each ml contains Activated Cow, buffalo & horse: 500 ml ACI charcoal—500 mg 0.25—0.5 ml per kg Sorbitol-500 mg body weight. Calf, pig, sheep & goat: 1 ml per kg body weight. Repeat dose after 12 hours as per need. Generic dose of Activated charcoal; Ruminants: 1–5 g/kg, PO. Indications: Used primarily to adsorb drugs and toxins in intestine to prevent their absorption. Ordinarily, a single dose is administered, but multiple doses will increase clearance of drugs that may undergo enterohepatic circulation. Clinical Pharmacology: Activated charcoal is the most valuable single emergency antidote since it acts by inactivating many organic toxicants by adsorption, a surface-active phenomenon. It is considered as universal antidote. It has been determined that charcoal inactivation of a toxicant in gastrointestinal contents, appears to be approximately stoichiometric and dose related in a linear fashion up to 70% to 85%. As a general rule it is safe to assume that 1 gm of activated charcoal will adsorb 70 mg to 90 mg of an ingested organic toxicant. Contraindications: It should not be given simultaneously or shortly before the oral administration of other therapeutic agents such as antibiotics & dewormers. It should be used 2 hours after oral administration of antibiotics & dewormers. Anti-spasmodic Indication: As antispastic in adjuvant treatment of digestive conditions (abdominal colic, gastric or duodenal ulcer, gastritis, enteritis, colitis, pancreatitis, spastic constipation, meteorism, spasms of cardia and pyloric sphincter, spasms of the biliary smooth muscles, biliary lithiasis, cholecystitis); spasms of urinary tract smooth muscles (renal urethral lithiasis, pyelitis, cystitis); genital disorders 80 (uterine tetanic contractions, severe pains, abortion imminence) in dog, cat, horse and cattle. The spasmolytic action of the product also causes pain killing up to removal. Drug Interaction: Levodopa (anti-perkinson effect may be decreased). Use in Pregnancy and Lactation: There is no known case of teratogenecity in animal studies. However, the use of Drotaverine should be avoided during pregnancy and lactation. Trade Name Composition Dose Pack Company Size Inj. Espa-Vet Each ml injection In Horses and Cattle: 160 mg– 10 ml Square contains Drotaverine 200 mg active substance (8-10 Hydrochloride INN 20 ml) by IM or SC route. Repeat mg. the dose 2–3 times/day if necessary. In case of acute abdominal colic, inoculate slowly 8 ml product by IV route. The dose may be repeated 2-3 times/day by IM or SC route Drug for Stomatitis Trade name Comosition Pulv. Apthocare Each 100 gm powder contains: Vitamin C—200 mg Potassium Iodate—100 mg Glutamic acid—50 mg (FMD, PPR, etc.) Trade dose Cattle, Buffaloes & Horses — 25 gm thrice daily for 5-7 days orally. Goats and Sheep’s — 15 gm thrice daily for 5-7 days orally. Usage Instruction — Please apply gently at recommended quantities thrice daily on the surface of the tongue of cows. Pack size 100 gm sachet pack Company SQUARE Mode of Action of apthocare: ✓ Vitamin C has reported to have antiviral properties as it stimulates interferon production. It is best known for the role in basement membrane collagen production deformities, capillary fragility, periodontal disease (disease of teeth) and bone deformities that characterize scurvy. ✓ It comprises iodate which enhances growth of the body to correct thyroid imbalance. ✓ It contains Glutamic acid which enhances the production of proline and hydroxyproline (both amino acid) to recover from sore by covering epithelial membrane. In this way sore is healed easily. Indication: Aphthous lesions very fast after affects of FMD, Thyroid imbalance, Ptyalism, Aftereffects of F&M leading to infertility and panting, Hypertrichosis Soln: FMD Each ml solution Wash all wound of mouth and 500 ml Acme CURE VET contains Natri carbonus foot and other wound of BP 40 mg. infected animal for 2-3 times daily until recovery. Pulv. No FMD Each 100 gm powder Infected animal: 5 gm/100 kg 100 gm ACI contains: BW. Glycerol MonolaurateHealthy animal: 2.5 gm/ 100 50 g kg BW. 81 Pulv. FL Care Vet {Maximum Care for FMD & Lumpy Skin Disease (LSD)} Nano-Coated Zinc Oxide—10 g Riboflavin (Vitamin B2)1g Sodium Hydrogen Carbonate—2 g Ethoxyquin—0.25 g Butailated Hydroxytoluene—0.25 g Di and Polysaccharide— 9.75 g Essential Oil, Trace Minerals & calcium Carbonate q.s. to 100 gm Each 100 gm powder contains Vitamin C- 3000 mg Potassium Iodide200 mg Glutamic Acid BP- 1500 mg Vitamin E- 2000 mg Zinc Sulfate Monohydrate-600 mg Cobalt Sulphate Heptahydrate- 10 mg Selenium Enriched Provide Direct/by Bnana leaf/ with feed for 5-7 days. Cattle & Buffalo: 25 grams Powder twice a day Sheep and goats: 15 grams Powder twice a day 100 gm SK+F In case of tongue infection, adequate amount of medicine should be applied on the wound site. Anti-diarrhoeal Preparations Indication: ✓ Non-infectious diarrhoea due to faulty diet, over feeding indigestion, Intestinal injury, hypersecretion, malabsorption & increased intestinal motility. ✓ As supportive therapy in infectious diarrhoea of viral, bacterial & protozoal origin. Trade name Composition Trade dose Pack size Company Pulv. DD-Nil Each 100 gm coatains LA: 100 gm powder, PO twice 100 gm ACI Pulv. Chalk—65 gm daily for 3-5 days. Sachet Pulv. Katechu-14 gm SA: 60 gm powder, PO twice Pulv. Kaolin-16 gm daily for 3-5 days. Pulv. Alum- 0.04 gm Powder should be mixed with 1-mono propionin-1 gm 1 L water. 1-mono butyrin-1 gm Sweet chestnut extract q.s. to-100 gm Pulv. Each 1 kg contains – LA: 100 gm once or 50 gm 100 gm ACI Recofast Rice flower: 100 gm twice in a day for 1-5 days Entericum Algae extract: 75 gm milk Powder serum powder: 50 gm SA: 20 gm once or 10 gm twice Dried Bear Yeast: 40 gm in a day for 1-5 days. Ground Creb: 30 gm 82 Pulv. DiarLock Vet Pulv. GutFix Pulv. Catorrhoea Pulv. Diagent Vet Tube. IG Lock Gold Carrot Flower: 25 gm NaCl: 10 gm MgCl2: 10 gm And Different Vitamin, feed additive, provitamin & other chemicals. Each gram contains Zeolite-370 mg Oregano oil- 5 mg Koalin- 100 mg Pectin- 5 mg Chestnut tannins- 10 mg Electrolytes-232 mg Sugars-263 mg Plant extract- 15 mg DL-Methionine: 5 gm, L-lysine HCl: 5 gm, Essenpro: 10 gm CaCO3: 100 g Each 100 g powder contains: Aegle marmelos: 24 g Zingiber officinale: 1.5 g Acacia catechu: 5 g Berberis aristata: 6 g Helicteres isora linn: 6 g Vakumbha: 6 g Alum: 6 g Holarrhena antidysenterica: 6 g Woodfordia fruticose: 6 g Copper sulphate: 3 g Calcium carbonate: 20.5 g Kaolin: 10 g Each 150 g powder contains: Pulv. Chalk—100 gm Pulv. Kaolin-50 gm Each tube contains egg yolk powder and fructooligosaccaride. Cattle, Buffalo: 50-70 gm daily Calf, Sheep, Goat: 20-30 gm daily 50 gm Navana LA: 15-20 gm daily for 3-5 days. SA: 5-10 gm daily for 3-5 days. 100 gm ACI Cattle, Buffalo: 25-50 gm Horse: 20-30 gm Sheep, Goat: 10-20 gm Dog: 5-10 gm Poultry: 5 gm 100 gm Fast Pharma 1 sachet /animal PO, BID, 2-3 days. 150 gm 200 gm Super Power One tube for each calf within 12 hours after birth. 10 gm tubes. ACI Administer with water or feed twice daily for 3 days. Prebiotics and Probiotics (Probiotics, Prebiotics, amino acid, vitamin, trace minerals & liver extract) Mode of action: Supply peptidase and polysaccharide to beneficial bacteria, increase growth of fiber, digestive bacteria. Indication: Milk & fertility increaser, ruminal stasis, indigestion, anorexia, intermittent diarrhea, Milk, probiotic and Gut prebiotic increaser, poor growth & production due to decreased ruminal function. Contraindication: Use of Bolus/powder with antibiotic may reduce its function partially or fully. 83 Use in pregnancy & lactation: is safe in pregnancy & lactation Trade Name Composition Trade Dose Bol. Biolact Each bolus contains, Large ruminants: 1- 2 bolus Live Yeast Culture- 3 g daily for 3-5 days. Activated Dry Yeast- 1 g Lactobacillus Sporogenes Small ruminants: ½ bolus Culture-50 million CFU daily for 3-5 days. Amino Acids (from Protein Hydrolysate)- 3 g Liver Extract- 6 mg Excipients q.s. Bol. Probolux Each 6 gm bolus containsDo vet Bacillus coagulans-3200 M CFU, Bacillus subtilis-300 M CFU, Bacillus licheniformis- 300 MCFU, Saccharomyces boulardii600 MCFU, Aspergillus niger-250 MCFU, Aspergillus oryzae- 250 MCFU, Mannan Oligosaccharide-300 mg, Vitamin B1-30 mg, Vitamin B6-30 mg, Vitamin C-60 mg, Biotin-5 mg, Amylase250 U, Protease-250 U, Phytase-30 U, Cellulase-30 U. Bol. Navapro Each bolus containsDo Plus Saccharomyces cerevisiae 20 billion CFU Lactobacillus sporogenes 300 million CFU Bacillus subtilis 100 million CFU Aspergillus niger 250 million CFU Fructo-oligosaccharides 250 mg Vitamin B1 50 mg Vitamin B6 30 mg DL-Methionine 500 mg L-lysine 100 mg Chelated Zinc 100 mg Chelated Copper 40 mg Chelated Cobalt 50 mg Amylase 20 U Lipase 20 U Protease 30 U Cellulase 30 U Pack Size 8×4 BOLUS Company Square 6 gm bolus Incepta 5x4's bolus Navana 84 Bol. Acilac plus Pulv. Rumen E Pulv. Rumi cell Each bolus containsSaccharomyces serivis: 15 billion CFU Lactobacillus sporogens: 100 million CFU Bacilus subtilis: 10 million CFU Methionine: 500 mg, Lysine: 200 mg, Zn: 100 mg, Cu: 40 mg, Co: 50 mg, Fungal amylase: 20 mg, Bita glucanase: 20 mg, Lipase: 20 mg, Protease: 20 mg, Cellulase: 20 mg Rumen E is a autolysed yeast for ruminants produced by a specific and constant autolytic degradation of the yeast cell content. It is spray dried & Process developed and optimized by BIOMIN R&D in order to guarantee a maximum of bioactive ingredients like Complex feed ingredient, combining nutrients (B-Vitamins, peptides, amino acids) with functional components such as RNA, nucleotides, cell wall carbohydrates in a better digestible form. Each 24 gm sachet contains: Saccharomyces cerevisiae 10X1010 CFU Lactobacillus sporogenes 10X107 CFU Aspergillus oryzae 10X107 CFU Biotin-20 mg DL-Methionine-8 gm Zinc Sulphate-400 mg Cobalt Sulphate- 80 mg Copper Sulphate-200 mg Fructo-Oligosaccharide- 1 gm Excipients q.s LA: 2-4 bolus daily for 7-10 day; SA: 0.5-1 bolus daily for 710 days 10 × 2 BOLUS ACI Lactating dairy cow: 10-15 gm/Cow/Day 100 gm sachet, 20 kg bag Renata 24 gm sachet Popular Calves: 10-15 gm/Calf/Day Feedlot beef cattle: 10-15 gm/Bull/Day Administer above dose 3-5 days Rumen E should be mixed directly into the feed. Continuous application helps to maintain rumen microflora balance and rumen function. Cattle, Buffalo & Horse: 200-300 kg BW: 12 gm BID for 3-4 days orally. Calf, Heifer, Foal, Sheep & Goat: 6 gm BID for 3-4 days orally. 85 Pulv. SALACGIL DS Pulv. Probiozyme (Probiotics & Enzymes) Pulv. Biogut Vet (Unique ProbioticPrebiotic formulation fortified with Yeast, Enzymes & Mineral Amino Acid Chelates) Each 12 gm sachet Saccharomyces cerevisiae5 X1010 CFU Lactobacillus sporogenes5 X107 CFU Aspergillus oryzae-5 X107 CFU Biotin – 10 mg DL-Methionine- 4 gm Zinc Sulphate – 200 mg Cobalt Sulphate – 40 mg Copper Sulphate – 100 mg Fructo-Oligosaccharide600 mg Excipients q.s Strychni semen – 1000 mg Flavour---sweet. Each kg contains, Bacillus subtilis 1.0x108 CFU, Bacillus licheniformis 1.0x108 CFU, Lactobacillus acidophilus 1.0x104 CFU, Lactobacillus plantarum 1.0x104 CFU, Cellulase 10,00,000 Unit, Xylanase 10,00,000 Unit, Beta-glucanase 5,00,000 Unit, Alpha-amylase 15,00,000 Unit, Protease 10,000 Unit, Phytase 25,000 Unit Each 10 g contains Lactobacillus acidophilus 1.0x107 CFU, Saccharomyces cerevisiae 1.0x108 CFU, Bacillus subtilis 1.0x109 CFU, Inulin 100 mg, DL-Methionine 500 mg, L-Lysine 200 mg, Zinc Chelate 100 mg, Manganese Chelate 60 mg, Copper Chelate 50 mg, Cobalt Chelate 10 mg, Selenium Yeast 1 mg, Amylase 20 mg, Lipase 20 mg, LA: 1-2 sachet orally, BID, for 2-3 days 12 gm sachet SK+F Cattle (dairy cow, beef): 2.5 grams per head per day or 1 g per 3-4 liters water. Goat: 250-500 grams per ton of complete feed or 1 gm per 3-4 liters water. 10 gm 100 gm Square Oral administration only 10 gm Acme SA: ½ -1 sachet orally SID/BID, for 2-3 days Large Animal: 1-2 sachet/animal/day for 7 days. Small Animal: ½-1 sachet/animal/day for 7 days. The above dosage & administration schedule should be followed in every month to ensure good health & optimum production. 86 Pulv Megalac-PF Pulv. Sangrovit Extra Protease 20 mg, Cellulase 20 mg, Beta-Glucanase 20 mg Xylanase 20 mg. Rumen protected fat and enzyme Mixture of flavouring compounds—77 % Sodium Chloride—20 % Ligninsulfonate (E565)—3 % Milking cow: 0.5-1 kg/100 kg feed or 20 gm/cow once daily. For fatening: 0.75-1.5 kg/100 kg feed or, 25 gm/cow twice daily. Sheep/goat: 0.5-1 kg/100 kg feed or 5 gm/animal once daily. Dairy Cow : 1.2-2.4 g per animal per day. Beef Cattle : 0.4-0.8 g per animal per day. Calf : 0.15-0.2 g per animal per day. 1 kg, 25 Kg ACI 5 kg ACI Nutritional products Vitamin preparations Vitamin B Complex Mode of action: Vitamin B-complex participate in the formation of enzymes and are indispensable for the metabolism of fats, proteins and carbohydrates and for normal growth of muscular and nervous tissue. Indication: Ruminants: Inappetance, weakness, ataxia, paresis, anorexia, diarrhoea followed by signs characteristic of polyencephalomalacia including blindness, head pressing, convulsions, paralysis, opisthotonos, poor growth, loss of hair, skin lessions, lacrimation & salivation, scours, metabolic disorders, microcytic hypochromic anaemia, nervous disorders, scally dermatitis around the mouth & muzzle, leukopenia. Horse: Lethargy, anorexia, weight loss, ataxia, cardiac arrhythmias, muscle tremors & convulsions. Contraindication: Diarrhea and other digestive disturbances. Use in Pregnancy and Lactation: is safe in pregnant and lactating animals. Trade Name Composition Dose Pack Company Size Inj. Bional Forte Each ml contains, Cattle, buffalo, Horse, 10 ml Techno Thiamine HCl (B1): 50 mg Goat, sheep: 5 ml IM, twice 100 ml Riboflavin (B2): 5 mg weekly. Nicotinamide (B3): 100 mg Cal-d-pentothinate: 10 mg Pyridoxine HCl (B6): 5 mg cyanocobalamin (B12): 2 mcg Inositol: 2 mg DL-methionine: 5 mg 87 Inj. B50-Vet DO Inj. V-plex vet Each ml contains Thiamine HCl (B1)—25 mg Riboflavin (B2)—2 mg Nicotinamide (B3) —50 mg D-Panthenol (B5 )—2.5 mg Pyridoxine HCl (B6)—5 mg Each mL contains Thiamine HCl (B1)—20 mg Riboflavin (B2)—1 mg Nicotinamide (B3 )—20 mg Pyridoxine HCl (B6)—0.5 mg cyanocobalamin (B12)—10 mcg Each mL contains Thiamine HCl (B1)—25 mg Riboflavin (B2)—1.5 mg Nicotinamide (B3 )—50 mg Pyridoxine HCl (B6)—5 mg cyanocobalamin (B12)—50 mcg Each ml contains Thiamine HCl (B1)—25 mg Riboflavin (B2)—2 mg Nicotinamide (B3) —50 mg D-Panthenol (B5 )—2.5 mg Pyridoxine HCl (B6)—5 mg Cyanocobalamin (B12)— 500 mcg Inj. B com vit Inj. Revit B Inj. Beco Vet Large animals (Cattle, Buffalo, Horse): 5-10 ml daily IM injection for 3 consecutive days in a week. Calves, Sheep, Goat: 1-2 ml daily IM injection for 3 consecutive days in a week. DO DO Square DO Acme IM/IV/SC route 50 mL, 100 mL 500 mL PHARMA & FIRM 10 ml 50 ml 100 ml Opsonin 10 ml 100 ml Popular Cattle, horses: 15-20 mL per head. Calves, sheep, goat: 10-15 mL per head. Swine: 5 – 10 mL per head. Piglets: 1 – 3 mL per head. Large animals (Cattle, Buffalo, Horse): 5-10 ml, IM, daily thrice in a week. Small animals (Sheep, Goat): 1-2 ml, IM, daily thrice in a week. Large animals (Cattle, Buffalo & Horse): 5-10 ml daily IM injection for 3 consecutive days in a week. Calves & small ruminants: 1-2 ml daily IM injection for 3 consecutive days in a week. Thiamine Hydrochloride (B1) Description : Thiamine (Vitamin B1) plays an important role in the metabolism of carbohydrates and energy production for all cells. Thiamine is most important in the breakdown of pyruvic acid a waste product in hard-working muscles along with lactic acid. In any situation where carbohydrates are the major energy source or when glucose is added to the diet, thiamine requirement is increased significantly. Thiamine is essential as part of the coenzyme which is involved in the breakdown of glucose for energy. Generic dose: Cattle, Sheep & goats: 10–20 mg/kg IM or SC 3 times daily; if giving IV dilute in isotonic saline or isotonic dextrose. For polioencephalomalacia: Initially, 10 mg/kg IV; then, 10 mg/kg IM twice daily for 2– 3 days. If no improvement within 4 days, may be advisable to recommend slaughter. Horses: 0.5–5 mg/kg IV, IM or PO Swine: 5–100 mg IM, SC, or IV. 88 Indication: Thiamine is indicated in the treatment or prevention of thiamine deficiency states. Symptoms of thiamine deficiency may be manifested as gastrointestinal (anorexia, salivation), neuromuscular/CNS signs (ataxia, seizures, loss of reflexes), or cardiac effects (brady-or tachyarrhythmias). Deficiency states may be secondary to either a lack of thiamine in the diet or the presence of thiamine destroying compounds in the diet (e.g. brocken fern, raw fish, amprolium, thiaminase-producing bacteria in ruminants). Thiamine has also been used in the adjunctive treatment of lead poisoning and ethylene glycol toxicity (to facilitate the conversion of glyoxylate to nontoxie metabolites) Use in Pregnancy and Lactation: is safe in pregnant and lactating animals. Trade Name Composition Dose Pack Company Size Inj. Thiavet Each ml contains Cattle, Buffalo, and Horses: 510 ml, Bridge Thiamine Hydrochloride 10 ml by intramuscular 50 ml pharma (Vit. B1) BP 100 mg. injection regularly twice 100 ml weekly. vial Calves: 2-2.5 -3.5 ml by intramuscular injection regularly twice weekly. Sheep and Goat: 2-2.5 ml by intramuscular injection regularly Nerve tonics Indication: Vit B1 deficiency, Nerve damage, Paralysis. Neuro-B® is a combination of Thiamine (Vit-B1), Pyridoxine Hydrochloride (Vit-B6) & Cyanocobalamin (Vit-B12). These vitamins play an essential role as co-enzyme in the cellular biochemical metabolism in the nervous system. Thus the combination normalizes metabolic condition of nerve cell and improves its condition. Neuro-B supports the regeneration of nerve fibers and myelin sheath by activation of the metabolism & the natural repair mechanism. Use in pregnancy & lactation: No sufficient data available. Trade name Composition Trade dose Vial size Company Inj. Neuro B Each 3 ml contains, 1 ml/10 kg BW, IM. 3 ml SQUARE Thiamin mononitrate (B1): ampoule 100 mg Pyridoxin HCl (B6) : 100 mg, Cyanocobalamine (B12): 1 mg Inj. Neuro best DO DO DO Renata Inj. Myelin DO DO DO Opsonin Tab. Neuro B Each tablet contains, 1 tab/10 kg BW, PO. SQUARE Thiamin mononitrate (B1): 100 mg Pyridoxin HCl (B6) : 200 mg, Cyanocobalamine (B12): 200 mcg Tab. Neuro DO DO Renata best Tab. Vitabion DO DO Incepta 89 Inj. Nervin Pulv.Ultravita3 Pulv. ESKAVIT B1, B2 Each 2 ml contains, Thiamin mononitrate (B1): 100 mg, Riboflavin (B2): 50 mg, Pyridoxin HCl (B6): 100 mg Each 100 g powder contains, Thiamin HCl (B1): 5 gm, Riboflavin (B2): 1 gm, Pyridoxin HCl (B6): 2 gm. Each kg powder contains, Thiamin hydrochloride (B1) BP- 50,000 mg Riboflavin (B2) BP- 10,000 mg 1 ml/10 kg BW, IM/IV. Cattle: 5 gm / 2.5 kg feed for 3-5 days Water: 1 gm / 1 liter of water; 5 days. OR, Feed: 10 gm / 4-5 kg of feed; 5 days. 2 ml ampoule JAYSON 100 gm Popular 100 gm sachet SK+F Vitamin A, D, E preparations Benefits of ADE Injection: ✓ prevents vitamin A, D3 & E deficiency syndrome ✓ increases fertility ✓ improves immunity ✓ enhances metabolism & promotes growth ✓ helps in the formation & preservation of epithelial tissue ✓ helps in the development of skeleton & teeth of young animal ✓ prevents stress associated with vaccination, diseases, transport, high temperature etc. Pharmacology: ✓ Vitamin A is a precursor of photopigment rhodopsin, influences the formation of secretory proteins and epithelial cell differentiation. ✓ Vitamin D3 helps in the absorption of calcium from the intestine and utilization. ✓ Vitamin E is an antioxidant that prevents stress caused by free radical reactions. Generic dose: Vit-A—Farm animals: 1-2 g/day Vit-D—C/H/S/P: 50-100 IU/kg/day Use in Pregnancy and Lactation: Safe drug for use during pregnancy and lactation Overdose: ✓ Vitamin A hypervitaminosis may cause drowsiness, teratogenic effects and skin degeneration. ✓ Vitamin D hypervitaminosis may cause hypercalcemia resulting organ calcification, renal and cardiovascular damage. ✓ Vitamin E hypervitaminosis may increase the requirement of vitamin K Trade Name Composition Trade dose Pack Size Company Inj. Renasol Each ml contains, IM/SC route 10 ml RENATA Ad3e Vet Vitamin A—500000 IU, Cattle, Buffaloes & Horse: 330 ml Vitamin D3—75000 IU, 6 mL 100 ml Vitamin E—50 mg Breeding cows: 2- 4 mL Bulls: 4-6 mL Calves, Sheep & Goats: ½ to 1 mL Inj. Hyvit ADEDo IM or SC use. Do AlVet Cow, horse, buffalo: 5-12 ml Madina per animal 90 Soln: Es-ADE Each ml Solution contains vitamin A-100000 IU, vitamin D3 -20000 IU vitamin E-20 mg. Soln. Acivit-ADE Soln: Eskavit ADE Soln: Remevit ADE Vet Soln. Nasol AD3E n Sol . SUPER ADE GOLD Do Do Calf, foal: 1-2 ml per animal Goat, Sheep: 1-2 ml per animal IM route Cattle, Horse, Buffalo: 5 ml per animal Calf, Foal, Goat, Sheep: 2 ml per animal IM/SC route Cattle, Buffalo, Horse: 5-10 ml Calf: 2-5 ml Sheep, Goat: 2-4 ml IM/SC route Cattle, Horse, Buffalo: 10 ml per animal Calf, Foal: 5 ml per animal Goat, Sheep: 4 ml per animal Cattle, Horses: 5-10 ml per animal Calves, Foals: 5 ml per animal Sheep & Goats: 2-3 ml per animal. Orally for 3-5 consecutive days Do Do Do Do Do Bengal Do 10 ml/Animal/day. Do Gentry Each 5 ml contains contains: Vitamin A: 2,50,000 iu Vitamin D3: 25,000 iu Vitamin E: 150 mg Vitamin C: 500 mg Protein hydrolysate:10 mg Each bolus contains Vitamin A—1,00,000 IU, Vitamin D3—10,000 IU, Vitamin E—30 IU Vitamin C—200 mg. CATTLE: 500 ml Axon 10×4 boli Acme Inj. Acivit-ADE Do Inj. Es-ADE Each ml injection contains, Vitamin A—80,000 IU, Vitamin D3—40,000 IU Vitamin E—20 mg. Do Inj. Vita-ADE Vet Bol. Vitaoral vet Do ACI 10 ml 100 ml SQUARE Do ACME 100 ml, 500 ml 1 Liter SQUARE Do Do ACI SK+F 1 ml/10 kg body weight/day General purpose/Beef Fattening: 1-2 bolus per animal daily for 3-5 days orally. To induce heat: 2-4 Bolus/ cow for 16 days. --For use in animal feed. --The bolus may be administered orally directly or through mixing with feed by grinding the bolus. 91 Bol. Anox-D Do Do Pulv. Adek vet Each sachet contains Vitamin A—500000 IU, Vitamin D3—200000 IU Vitamin E—200 mg Vitamin k3—50 mg. Cattle, Buffalo: 1 sachet/ animal for 15 days. Sheep, Goat: ¼ sachet/animal for 15 days. 35 bolus pot 5 gm Opsonin SK+F Vitamin C Indication and Uses: Envit-C® liquid is indicated for Vitamin C deficiency, stress, gastritis, supportive treatment in healing of ulcers, burn, fracture, development of immunity etc. It is especially valuable in tuberculosis of lungs, respiratory distress, etc. It also acts as an antioxidant and prevents ageing. Generic dose: Water soluble Vitamin-C (Ascorbic acid): Bull: 1-2 g SC, every 3-4 days up to 6 weeks Cow: 1-2 g IV & 2 gm SC before mating or 2 gm SC once or twice a week for up to 6 doses Horse: 2-4 g SC. Use in Pregnancy & Lactation: No adverse effect of Envit-C® liquid has been reported. Drug Interaction: Large dose of vitamin C may interfere with the absorption and metabolism of vitamin B12. Trade Name Composition Trade dose Pack Size Company Liq. Envit-C Each 100 ml liquid Large animal: 4 ml liquid 100 ml Square contains extracts of – per 10 kg body weight daily 1 Liter (Natural Vitamin Emblica officinalis for 3-4 consecutive days. C) 66.66 ml & Piper longum 2.64 gm. Vitamin D Indication: ✓ Fulfils dietary deficiency of Vitamin D ✓ Maintains proper meat and milk production ✓ Ensures proper calcium absorption in ruminants ✓ Prophylactic and therapeutic use in case milk fever, ketosis, weak bone, rickets, mastitis and any other calcium/phosphorus deficiency syndromes of ruminants Trade Name Composition Trade dose Pack Size Company Liq. D-BalanceVitamin D3 Cattle: First two days 200 ml twice 100 ml, Square Vet daily followed by 100 ml twice daily 500 ml for next 2 days. 1L To prevent ketosis & milk fever 100 ml once daily for 10 days after parturition. Liq. VITA-D PLUS Each 100 ml Do 100 ml Acme VET contains Vitamin D3 500000 IU Propylene Glycol q.s. to 100 ml Vitamin E + Selenium 92 Mode of action: Both vitamin E and selenium are involved with cellular metabolism of sulfur. Vitamin E has antioxidant properties and, with selenium, protects against red blood cell hemolysis and prevents the action of peroxidase on unsaturated bonds in cell membranes. Indication: For the prevention or treatment of Vitamin-E or Selenium deficiency like Muscular dystrophy / White Muscle disease, Encephalomalacia, & such as supportive therapy for poor immunity, muscle stiffness, weakness, lameness, infertility, retained placenta & mastitis. Increases the fertility of cattle & acts as an antioxidant. Increases body weight & milk production. Generic dose of Vit-E: All young: 25 mg/kg SC/IM Calves & Lambs: 40 mg/kg/day Pig: 500 mg/day orally Side Effect: It is safe even when use 100 times more the body requirement Contra-indication: Hypovitaminosis, diarrhoea. Trade Name Composition Trade dose Pack Size Company Inj. E-vet plus Each ml contains, 2 ml/10 kg bw SC/IM 30 ml ACME Vit E- 50 mg repeat 2-3 wks interval 100 ml Sodium selenite- 0.5 mg vial Liq. Sel-E Nano Each ml contains Cattle : 1-2 ml in 10 kg 100 ml Popular Alpha-tocopherol acetate body weight for 5-10 500 ml days. 1 L Bottle I: 100 mg, Sodium Selenite-0.5 mg/ 500 mcg. Liq. E Sel Do Do Do SQUARE Liq. E-Vet plus Do Do Do ACME Susp. Rena Sel-E Sol. OSE Vet Bol. Sel-E Each ml contains Vitamin E—80 mg, Selenium—0.6 mg Each ml contains Vit E acetate-100 mg Selenium – 0.2 mg Each Bolus contains Vitamin E—800 mg Sodium Selenite—4 mg Do 100 ml 1L Do 20 ml 100 ml 500 ml 5×4 boli Cattle: 1-2 bolus per day per cattle for 5-10 days RENATA SK+F Popular Multivitamin preparations MECHANISM OF ACTION: Vitamin A- can affect the biosynthesis of various proteins, including those involved in the regulation of development and cell functioning. Vitamin A can also influence the formation of secretory proteins which play the role of hormones. Vitamin D3—has a crucial role in providing the proper balance of minerals necessary for bone growth and function. Vitamin E—is an antioxidant which that prevents free radical reactions. Thiamine (Vitamin B₁) helps the body’s cells change carbohydrates into energy. Thiamine also plays a role in muscle contraction and conduction of nerve signals. Riboflavin (Vitamin B₂) is important for body growth. It helps in red blood cell production. It also aids in the release of energy from proteins. Niacin (Vitamin B3) decreases lipids and apolipoprotein B (apo B)-containing lipoproteins by modulating triglyceride Pyridoxine (Vitamin B6) is significant to protein, fat and carbohydrate metabolism and the creation of red blood cells and neurotransmitters. 93 Cobalamin (Vitamin B12) keep the body’s nerve and blood cells healthy and helps make DNA, the genetic material in all cells. Vitamin C (ascorbic acid)—dissociates at physiological pH to form ascorbate, the redox state of the vitamin which is found most abundantly in cells.It is well known that ascorbate acts physiologically as a reductant and enzyme cofactor. D-Panthol is well absorbed into the skin and quickly converted into Pantothenic acid by oxidation. Pantothenic acid is distributed into the cells and is converted to Acetyl Coenzyme-A (Acetyl CoA) in the cells of the epidermis. Panthenol penetrates the lower skin layers and imbues water into the cells and retain moisture deep within the tissue. Indications: Ruminants: Inappetence, weakness, ataxia, paresis, anorexia, diarrhea followed by signs, characteristic of polioencephalomalacia. Horse: Lethargy, anorexia, weight loss, ataxia, cardiac arrhythmias, muscle tremors & convulsions. Contraindication: Diarrhea and other digestive disturbance. Use in Pregnancy and Lactation: is safe in pregnant and lactating animals. Trade Name Composition Trade dose Pack Company Size Soln. Each 100 ml contains Calf: 5 to 10 ml/ day for 5 100 ml Acme Vitalamino Vitamin A—2000000 IU, consecutive days/ month 500 ml forte vet Vitamin D3—500000 IU, Heifer: 30 ml day for 5 1L Vitamin E—500 mg, consecutive days/ month Vitamin B1—100 mg, especially just before Vitamin B2—200 mg. reproduction time Vitamin B6—200 mg, Beef cattle: 20 to 30 ml/ day Vitamin B12 —1 mg, for 5 consecutive days/ Vitamin C—300 mg, month. Vitamin K3—100 mg. Dairy cow: 30 to 50 ml day Biotin—200 mcg, for 5 consecutive days/ Sodium (chloride)—500 mg month or 5 ml/ Sodium propionate-500 mg, dairy cow/ day. Magnesium (sulphate)-150 mg. Manganese (sulphate)—60 mg. Zinc (sniphate)—60 mg. Iron (sulphate)—2 mg. Potassium—100 mg, Glutamic acid—350 mg, Lactic acid—400 mg, Citric acid—20 mcg. Alanine—75 mg. Arginine—100 mg. Potassium citrate—300 mg, Cystine—20 mg. Glycine—300 mg, Histidine—52.5 mg, Isoleucine—50 mg. Lysine—500 mg. Methionine—150 mg. Phenylalanine—90 mg. Proline—90 mg, 94 Inj. Multivit Vet Inj. Xtravet Inj. Super amino Vet Serine—90 mg, Threonine—300 mg. Tryptophan—60 mg. Tyrosine—65 mg & Valine 80 mg Each ml injectable solution contains Vitamin A—15,000 IU, Vitamin D—0.025 mg. Vitamin E—0.02 gm, Thiamine HCl (B1)—0.01 gm, Riboflavin (B2)—0.005 gm. Nicotinamide (B3)—0.035 gm, Pyridoxine HCl (B6)—0.003 gm Cyanocobalamin (B12)—0.025 mg Dexpanthenol—0.025 gm Each mL solution containsVitamin A BP 20000 IU, Vitamin D3 BP 10000 IU, Vitamin E BP 8.00 mg, Vitamin B1 BP 5.00 mg, Vitamin B2 BP 2.00 mg, Vitamin B3 BP 24.50 mg, Vitamin B6 BP 2.45 mg. Vitamin B12 BP 5.00 mcg. Vitamin C BP 5.00 mg and D-Panthol BP 6.00 mg. Vitamin, Mineral Amino acid, IM/SC injection Clean the area of the injection site and swab with spirit. Ensure that all injection equipment is thoroughly cleaned and sterilized before use. Horse and Cattle: 20-30 ml Calf, Foal, Sheep: 5-10 ml Weaner and Lamb: 2-5 ml The injection may be repeated at intervals of 10 to 14 days. Intramuscularly. Cattle, Buffalo & Horse: 5-10 mL daily for consecutive 3 days. 10 ml Square 10 ml, 30 ml, 50 ml, 100 ml Techno 250 ml 500 ml ACI Sheep, Goat: 1-2 mL daily for consecutive 3 days. 10-50 ml/ 5 kg BW, IV/IM DB vitamins Usage: Weakness, loss of appetite, nutritional deficiency, deficiency due to acute and chronic diseases, therapeutic treatment, retarded growth of ruminant animal, for better milk, meat production & fertility. To maintain physiological activities in stressed conditions & for recovery after diseases. Mode of action ✓ Vitamin A is used for better growth & disease prevention. ✓ Vitamin D3 is used for precise absorption of calcium & phosphorus. ✓ Vitamin E is used as antioxidant & to avoid sterility problem. ✓ Cobalt helps the synthesis of Vitamin B12, enzymes that produce DNA & acts as catalyst for metabolism of proteins to amino acids. ✓ Copper maintains normal color of skin, fur and hair, acts as catalyst for various enzymatic reactions during R.B.C. synthesis. ✓ Iron helps synthesis of R.B.C. & many enzymes, ferritin (Iron containing protein). ✓ Iodine is a precursor for synthesis of thyroid hormones. Newborn dies due to the deficiency of iodine. ✓ Manganese helps in reproduction process & formation of bones. 95 ✓ Zinc activates many essential enzymes, eliminates parakeratosis disease and prevents hair loss. ✓ Selenium helps in feed metabolism & Vitamin E synthesis. ✓ Magnesium is an important component of bone, acts as a catalyst for various enzymes and controls ✓ neuromuscular stimulation. Contraindication: Based on animal need, If deficiency, then can be used with caution based on patient benefit incase of diarrhoea. Trade Name Composition Dose Pack Size Company Pulv. Eskavit Each kg powder contains; Cattle & Buffalo: 10-20 100 gm SK+F DB plus Vitamin A 6.00 MIU gm per animal for Sachet, Vitamin D3-2.00 MIU consecutive 5-10 days. 250 gm Vitamin E 0.75 gm Calves, Goats & Sheep: Sachet, Copper 1.00 gm 5-10 gm per animal for 1 kg Cobalt 0.80 gm consecutive 5-10 days. container Iodine 0.18 gm Collective treatment: 5 kg Calcium 237.00 gm 10-20 kg powder per Gusset Selenium 1.00 mg ton of feed for Phosphorus 54.00 gm consecutive 5-10 days.. L-Lysine 1.17 gm Magnesium 5.00 gm Methionine 2.25 gm Manganese 1.00 gm Zinc 2.00 gm Iron 2.00 gm Antioxidant, Anticaking & Aromatized excipient q.s 1 Kg Pulv. Renavit Each gram contains, Do 100 gm, RENATA DB Plus Vitamin A 6000 IU 500 gm, Vitamin D3 3000 IU 1kg Vitamin E 0.3 mg, Vitamin B2 0.3 mg, Vitamin B6 0.6 mg, Vitamin B12 0.4 mg, Vitamin K3 0.04 mg, Niacin 44 mg, Folic Acid 0.01 mg, Zinc 24 mg, Copper 12 mg, Manganese 240 mg, Selenium 0.18 gm Essential Amino Acid 0.18 g Pulv. Vitamix Each Kg contains Large animal (Cow, 500 gm, ACME DB Vitamin A—600,000 IU Buffalo): 10 – 20 gm 1kg Vitamin D3—200,000 IU daily. Vitamin E—100 mg Cobalt—100 mg Small animal (Goat, Copper—1,000 mg Sheep): 5 – 10 gm daily. Iron—10 g Selenium—30 mg Calf: 5 g daily. 96 Pulv. Biomix DB Pulv. Promix DB Plus Molybdenum-50 mg Magnesium—5 g Manganese —5 g Zinc—4 g Calcium—260 g Phosphorus—65 g Selenium—30 mg Iodine—60 mg Each Kg contains, Vitamin A 100 Lac IU, Vitamin D3 10 Lac IU, Vitamin E 10 g, Co 0.8 g, Cu 6 g, Fe 80 g, Iodine 2.5 g, Mn 50 g, Mg 100 g, Se 0.1 g, Zn 45 g Vitamins, Minerals, Selenium etc. Pulv. DB 52 52 essential elements, Vitamin, mineral, amino acid, Enzyme Pulv. Megavit DB Vitamin, Mineral & Amino acid Pulv. DB Vitamin Each Kg containsVitamin A 600,000 IU Vitamin D3 200,000 IU Vitamin E 75 mg Vitamin B1 100 mg Vitamin B2 200 mg Vitamin B6 10 mg Vitamin B12 -1,100 mcg Vitamin K3 25 mg Karnitin HCl 10,000 mg Sodium Glutamate 7,500 mg Sodium Chloride 25,000 mg Magnesium 5,000 mg Manganese 1,000 mg Zinc 1,000 mg Iron 2,000 mg Copper 500 mg Nicotinic Acid 1,250 mg Cobalt 500 mg Choline Chloride 500 mg Iodine 180 mg Methionine 10,000 mg Di-Ca PO4 300 mg Mix 1 gm powder with 1 kg feed of animal daily. 100 gm, 500 gm container TECHNO Do 100 gm 500 gm 1000 gm 1 kg bucket Gentry 1 kg NOVARTIS 100 gm 500 gm 1kg SQUARE Buffalo, cattle: 20-30 gm for consecutive 510 days. Calf, goat, sheep: 10-15 gm for consecutive 510 days. Cow and buffalo -20 gm daily Calf/sheep/goat—10 gm daily For combined therapy: 10-20 kg of DB-Vitamin mixed in 1 Metric Ton of feed should be fed for 5-10 days. For Individual animal: Cattle/Buffalo: 20 -30 gm of DB-Vitamin should be given orally for 5-10 days Calf: 10-15 gm of DBVitamin for each calf should be given orally for 5-10 days. Sheep/ Goat: 10-15 gm of DB-Vitamin for each calf should be given orally for 5-10 days ACI 97 Pulv. Vitamix DB Super Pulv. Ultravita DB Pulv. SQUARETRP (High Quality Natural Energy Supplement) Pulv. Albivit DB Premix Bol. PhoscalDB Bol. Calvita DB L-Lysine 2,500 mg Calcium Carbonate 440 mg Xentian Extract 5,000 mg Excipient QS 1,000 gm Each Kg contains Vitamin A—600,000 IU Vitamin D3—200,000 IU Vitamin E—100 mg Vitamin B12—500 mcg Niacin—100 mg Cobalt—100 mg Copper—1,000 mg Iron—5.2 g Iodine—60 mg Manganese—2.5 g Magnesium—5 g Zinc—4 g Molybdenum—50 mg Calcium—260 g Phosphorus—65 g Selenium—30 mg Potassium—20 mg Sodium—45 mg Sulphur—5 g Vitamin, mineral and amino acids Proximate Analysis: Starch: 45-50% min Raw Fiber: 15% max Moisture: 14% max Protein: 3% Ash: 3% max Silica: 0.85% max Energy: 3,600 Kcal/kg Multivitamin and Multiminerals Each bolus contain, Vit D3, B12, Mg, Ca, P Calcium, Phosphorous, Vitamins Cow, Buffalo: 10 – 20 g daily. 1 kg ACME 1 kg POPULAR 10 kg Square 500 gm ALBION 50 Bolus container OPSONIN 20 pcs pcs, 100 pcs container Gentry Goat, Sheep: 5 – 10 g daily. Calf: 5 g daily. Cattle/Buffalo: 20 -25 gm of Ultravita DB Gold should be given orally for 5-10 days or Administer 1 kg Ultravita DB Gold in 100 kg concentrate feed. Large animals: 500 gm1 KG/100 kg body weight per day. Other animals: 150 gm250 gm/50 kg body weight per day. 20-30 g daily for 5-10 days Cow, Horse, buffalo- 2 Bol/day Calf, goat and sheep-1 Bol/Day DO 98 Mineral preparations Calcium preparations (Injectable) Pharmacology/Actions: ✓ Calcium: Calcium is an essential element that is required for many functions within the body, including proper nervous and musculoskeletal system function, cell membrane and capillary permeability, activation of enzymatic reactions, and is required for maintenance of a normal cardiac rhythm, blood clotting and initiation of metabolic activities. ✓ Magnesium: Magnesium is an essential electrolyte, a co-factor in numerous enzyme systems and involved in phosphate transfer, muscle contractilities and neuronal transmission. ✓ Phosphorus: Phosphorus is a key component in energy and protein metabolism and also is a structural part of bone. Generic dose-Calcium Gluconate: 1 gm/45 kg, IV, IM, SC. Indication: indicated for increasing milk production, fattening, prevention & treatment of milk fever, grass tetany, neonatal hypoglycemia, general debility due to parasitic infestations, lactation tetany, ketosis in cattle and as a supportive to anthelmintic treatment in Cattle, Buffaloes, Sheep & Goats. It is also indicated for the deficiency diseases of calcium, magnesium, phosphorus & glucose. Side effects: Untoward cardiac or respiratory symptoms may appear during administration. If such symptoms appear, reduce the rate of injection or discontinue altogether to restore normal function. Precautions: Although IV administration is often preferred route and is being used, caution must be taken to monitor cardinal signs of the treated animal, particularly the cardiac rhythm. Calcium is cardiotoxic; therefore, Calcium containing solutions should be administered slowly (10-20 min) while cardiac auscultation is performed. If severe dysrhythmias or bradycardia develop, administration should be stopped until the heart rhythm returns to normal. Endotoxic animals are especially prone to dysrhythmias caused by IV Calcium therapy. Administration: Drug should be mixed with equal amount distilled water or NS for IV. Use in Pregnancy & Lactation: Epidemiological studies have shown no teratogenic hazard to the fetus. Trade Name Composition Dose Pack Company Size Inj. Calcium Each ml contains 1 ml/4.5 kg BW, IV. 5 ml JAYSON Jayson Ca-gluconate BP—100 mg (as 1 gm/45 kg) Ampules Inj. Decam Each 200 ml contains For IV, Subcutaneous or 200 ml ACME vet Calcium—3.72 g Peritoneum use only. Magnesium—0.93 g Cattle & Buffaloes: 200-350 Phosphorus—2.36 g ml/animal. Dextrose—40 g Goats & Sheep: 25-50 ml/ Boric Acid—9 g. animal Dosage may be repeated if necessary. Inj. Calcivit Each 100 ml contains, 100-350 ml /animal IV/SC. 100 ml ACI plus Calcium Gluconate—20.8 vial gm Magnesium Hypophosphite—5 gm Dextrose Anhydrous—22 gm Boric Acid—4.2 gm Inj. CalciEach ml contains, IV/IM/SC route 100 ml ACI Max Calcium Gluconate—450 mg 99 Inj. Caldex vet Inj. Caldex Vet Forte Inj. Magical 28 Inj. Caldimax Inj. Caldifos Vet Inj. Cal-DMag Vet Inj. Mifenil Vet Calcium Glubionate- 20 mg Calcium Acetate—37 mg Magnesium Hypophosphite-6hydrate—30 mg Each ml contains Calcium Gluconate BP— 208 mg Magnesium Hypophosphite Ph. Grade—50 mg Dextrose BP—200 mg Boric Acid BP—42 mg Each ml contains Calcium Gluconate BP— 250 mg Magnesium Chloride Hexahydrate BP—30 mg Dextrose BP—50 mg Boric Acid BP—30 mg Each 100 mL contains Calcium Gluconate—28 g, Magnesium Hypophosphite Hexahydrate—9.00 g and Boric acid BP—5.75 g. Each ml contain Calcium glycerophosphate -5 mg, Calcium lactate -7.002 mg. Each 100 ml contains: Ca gluconate – 20.8 gm, Mg hypophosphite—5.5 gm Dextrose monohydrate— 20 gm, Cal-D-Mag® 200 mL will provide: Calcium—3.72 gm Magnesium—0.93 gm Phosphorus—2.36 gm Dextrose—40 gm Boric Acid—8.4 gm Each ml containsCalcium Gluconate—208 mg Magnesium Hypophosphite—50 mg Dextrose Monohydrate220 mg Boric Acid—42 mg Cattle, Horse & Buffaloes: 80100 ml/ 500 kg BW. Calves, Goats & Sheep: 15-25 ml/ animal. subcutaneously or intravenously 100 ml 250 ml POPULAR 250 ml POPULAR 100 ml, 250 ml, 500 ml SK+F 30 ml 100 ml TECHNO 100 ml, 200 ml Amber color vial TECHNO IV/SC route Cattle, Buffalo: 200-350 ml Sheep/Goat: 25-50 ml, IV/ SC 500 ml RENATA Cattle, Buffalo: 200 — 350 ml Calves, Sheep, Goat: 25- 50 mI If needed, dosage may be repeated. 100 ml SQUARE Cattle & Buffalo: 100 — 350 ml Calf, Goat & Sheep: 25 — 50 ml by intravenously, intramuscularly or subcutaneously Cattle & Horse : 100-500 ml Calf, Goat & Sheep : 50-100 ml Dog : 10-20 ml Slow IV/SC: 0.5-1 mL per kg body weight 2 to 3 consecutive days. Oral: 10 ml/ liter water, 2 to 3 consecutive days. Cattle: 10 ml/45 kg BW, IM. Sheep, goat: 5-10 ml/animal IM Cattle, Buffalo, Goat, Sheep: 1 ml/ kg of body weight, IV. 100 Calcium preparations (Oral) Indication: • Prevents milk fever after calving • Improves milk production • Enhances growth in growing animal • Prevents rickets and osteoporosis in animals • Also prevents Calcium & Phosphorous deficiency diseases. Trade Name Composition Dose Susp. Calvet-P Susp. Calvit P Susp. Bonacal-P oral Susp. Sancal vet Oral Susp. Phoscal PD Susp. Rena Cal P Liq. Calpha PD Plus In 20 ml preparationCalf, goat, sheep: 20-25 Calcium 325.60 mg, ml, PO, twice daily for 7-10 Magnesium 20 mg, days per each month. Phosphorous 167.70 mg, Cattle, buffalo: 100 ml, PO, Vitamin B12 20.00 mcg, daily for 7-10 days per Vitamin D3 1600.00 IU each month. Do Do + Sucrose: 5 gm 1 ml containsDo Ca: 17 mg P: 8.5 mg B12: 1 µg D3: 80 IU Sucrose: 400 mg 1 ml containsDo Ca: 16.5 mg, Mg: 1 mg P: 8.5 mg, Vit B12: 1 mg Vit D3: 80 IU Carbohydrate-200 mg With permitted flavour and colour 1 ml containsDO Ca: 400 mg; P: 200 mg, Vit B12: 1 µg; Vit D3: 80 IU Each 20 ml contains Do Phosphorus—0.2 gm Cobalt—25 mg, Copper—2 mg, Manganese—10 mg, Vitamin A—800 IU Vitamin D3—1600 IU Vitamin B12 –20 mcg Natural C—100 mg, Natural E—100 mg, Lysine—20 mg, Methionine—20 mg, Leptadinia reticulate— 800 mg, Asperagas recimogus—50 mg Do Do Pack Size 500 ml, 1L Company 1 liter 5 litre SQUARE Do ACI 1 liter Elanco 500 ml, 1L OPSONIN 1L 5L RENATA Do POPULAR ACI 101 Liq. CP-vet Liq. Renacal-P Liq. Oracal vet Liq. Minacal Plus Liq. Calplex Vet Soln. AciPlex Vet Bol. CP-vet plus Each 20 ml contains Calcium—325.6 mg Magnesium—20 mg Phosphorus—167.7 mg Vitamin B12 —20 mcg Vitamin D3—1600 I.U Each 20 ml contains Calcium—480.40 mg Phosphorus—167.7 mg Cobalt—25 mg, Copper—2 mg, Manganese—10 mg, Vitamin A—800 IU Vitamin D3—1600 IU Vitamin B12 –20 mcg Natural C—100 mg, Natural E—100 mg, Lysine—20 mg, Methionine—20 mg, Leptadinia reticulate— 800 mg, Asperagas recimogus—50 mg Each Litre contains Calcium—3500 mg Phosphorus—1750 mg Vitamin B12 – 200 mcg Vitamin D3—20000 IU Copper—50 mg Biotin- 2 mg Carbohydrate-40000 mg Energy Value- 160 cal. Calcium enriched with vitamins, minerals and Shatavari extract Each litre solution containsCalcium—3.40 % Phosphorus—1.70 % Vitamin D3-2,000,000 I.U. Do Each bolus contains Calcium—830 mg Phosphorus—500 mg Magnesium—375 mg Potassium—250 mg Sodium—125 mg Do 1L ACME Do 1 L, 5L RENATA Deshi breed-50 ml/day Cross breed-100 ml/day Sheep,goat-20 ml/day 1L 5L SK+F Cattle and Buffalo: 80-100 ml/day for 7-10 days (oral administration) Calf, Sheep and Goat: 2040 ml/day for 7-10 days (oral administration) For large animal: 30-50 ml daily for 5-7 days. For Calve, Goat & Sheep: 10-20 ml daily for 5-7 days. Do Do Incepta 100 ml, 1 liter SQUARE 100 ml, 500 ml 20 bolus ACI For use in animal feed. Cattle, buffalo, horse: 4 boli/animal/day for 3-5 days. ACME 102 Vitamin D3—12500 IU Vitamin E—75 IU Vitamin B12—25 mcg Bol. Calpha DB Bol. Calvet-DB Bol. Phoscal DB Gel. Cal-Boost Each bolus contains: Calcium—1.4 g Phosphorus—1.0 g Vitamin D3—8000 IU Vitamin B12—150 mcg DO DO Each 300 ml contains, Calcium-43.5 g Magnesium-2.5 g Calves, Sheep, goat: 2 boli/animal/day for 3-5 days. CP-Vet Plus can also be used as follow-up treatment after IV administration of DECAM Vet in hypocalcaemia. CP-Vet Plus bolus may be administered orally directly or through mixing with feed by grinding the bolus. Cattle, Horse & Buffalo: 2 Bolus once daily Calf, Goat & Sheep: 1 Bolus once daily DO DO Administer 6 to 12 hr before delivary1 bottle 18-24hr after delivary-1 bottle 10 X 4 boli POPULAR DO DO 300 ml bottle ACI OPSONIN RENETA Di-Calcium Phosphate preparation Pulv. ACI DCP Gold Pulv. DCP BOOST Pulv. Super DCP Each 1 kg contain – Ca phosphate-90%, MgSO4: 2%, NaCl-6%, ZnO: 0.02%, I2, Casin, Frocto oligosaccharide: 0.02% Trace element (Fe, Mn, I2, Cu, Zn, Co)- 1.96% Di-Calcium Phosphate, Vitamins & Minerals Cattle, Horse & Buffalo: 15 gm/100 kg BW. Goat & Sheep: 1 gm/5 kg BW. 1 kg, 5 kg ACI Do 1 kg Albion Each kg Contains Di-Calcium Phosphate900 g Magnesium Sulphate-20 g Sodium Chloride-60 g Elements (Fe, Mn, I, Cu, Zn, Co)-20 g Cattle, Horse & Buffalo: 12 gm/100 kg BW. Goat & Sheep: 1 gm/7 kg BW. 1 kg AgroVet Zinc preparations Pharmacology/Actions: Zinc is a necessary nutritional supplement; it is required by over 200 metalloenzymes for proper function. Enzyme systems that require zinc include alkaline phosphatase, alcohol dehydrogenase, carbonic anhydrase, and RNA polymerase. Zinc is also necessary to maintain 103 structural integrity of cell membranes and nucleic acids. Zinc dependent physiological processes include sexual maturation and reproduction, cell growth and division, vision, night vision, wound healing, immune response, and taste acuity. When administered orally, large doses of zinc can inhibit the absorption of copper. Indication: is indicated for inappetance, diarrhoea, poor growth, alopecia, dermatitis, reduced testicular growth, swollen feet, wounds failed to heal properly, wool-eating, parakeratosis, hyperkeratosis, stiffness of the joint, malformed hoof, impaired reproduction, immunologic dysfunction, reduced production etc. Drug Interaction: Should not be taken at the same time as the antibiotic (tetracycline) because it interferes the absorption & effectiveness of this medication. Trade Name Composition Trade dose Pack Company Size Syp. ZesupEach 5 ml syrup Cattle/ Buffalo: 50-100 ml daily for 5-7 100 ml SQUARE vet contains Zinc days 500 ml Sulphate Calf/ Goat/ Sheep: 25-30 ml daily for 5Monohydrate— 7 days 10 mg. Soln. XincDO Do 200 mL SK+F Care 500 mL Liq. Azinck DO Do 100 ml ACI vet Soln. Zis vet DO Cattle, Buffalo DO ACME Prevention: 100 ml solution per 5 kg feed daily. Treatment: 50-100 ml solution per animal daily for 5-7 days. Calf, Sheep, Goat Prevention: 100 ml solution per 5 kg feed daily. Treatment: 25-30 ml Zis-Vet solution per animal daily for 5-7 days. n Sol . Ozinc Each ml contains, Do Do RENATA Zinc Methionine Hydroxy Analogue—85 mg n Sol . Soluzink Each 5 ml Cattle (100-120 Kg): 100-150 ml for 3-5 Do POPULAR Vet contains Zinc days Sulphate Calf (40-50kg): 40-50 ml for 3-5 days Monohydrate— 10 mg. Liq. Albi Zinc Zinc—0.2% 50-100 ml/100 kg body weight 1L Albion (Vet) Liq. Each ml contains, Cattle & Buffalo: 20–30 ml daily for 5-7 DO Bengal Remezinc Zinc sulphate days Vet monohydrateCalf, Goat & Sheep: 10 ml daily for 5-7 6 mg days Vitamin D3 200 IU Bol. Zis vet Each bolus Cattle, Buffalo 20 ACME contains Zinc Prevention: 1 bolus per 5 kg feed daily. bolus 104 Sulphate Monohydrate200 mg. Bol. Ready Zink 200 Bol. Ready Zink 600 ZnSO4 monohydrate: 200 mg/bolus ZnSO4 monohydrate: 600 mg/bolus Treatment: 1 bolus per animal daily for 5-7 days. Calf, Sheep, Goat Prevention: 1 bolus per 5 kg feed daily. Treatment: One-forth to one-half bolus per animal daily for 5-7 days. Cattle (Small — Medium): 1 bolus in each cattle for 3-5 days per pack 200 mg bolus POPULAR Cattle (250-300 kg wt.): 1 bolus in each cattle for 3-5 days 600 mg bolus POPULAR Butaphosphan, Toldimphos, Cyanocobalamine Mode of action : • Butaphosphan a parenteral source of phosphorous, stimulates metabolic system and modulates the immune system. It improves hepatic function and boosts energy metabolism. • Cyanocobalamin (Vitamin B12) influences the formation of red blood cells and stimulates the growth. • Toldimfos sodium is the sodium salt of 4-dimethylamino-2-methyl-phenyl-phosphinous acid, a derivative of phosphoric acid. It is indicated for the treatment and prophylaxis of diseases which arise in connection with parturition and the peri-partum period, developmental and nutritional disorders in young animals, disorders of bone growth and tetany or paresis caused by disorders of calcium, magnesium and phosphorous metabolism. Indications: Cattle: • Increase muscular performances in animals kept for Fattening, breeding & other purposes. • Metabolic disorders in case of poor nutrition, inadequate management, care or diseased condition. • Tonic in case of weakness, secondary anaemia & excretion. Roborant in case of stress, over exertion & reduced resistant to healthy animals. • Tetany & paresis in addition to Ca & Mg therapy. • Disorders in growth & nutrition of young animals due to disease in early life. • Metaphylaxis of infertility, puerperal disease & to support treatment of infertility. • Remove deficiency signs of Phosphorus. Generic dose; Butaphosphan with cyanocobalamin-Horse, Cattle: 1–2 mL per 100 lbs (45 kg) body weight SC, IM, or IV; repeat daily as needed. Use in Pregnancy and Lactation: No ingredients in the product have been shown to produce reproductive effect. Safe in lactating period of animals. Trade Name Composition Dose Pack Company Size Inj. A-sol vet Each ml contains IM/IV/SC route 100 ml ACME Butaphosphan INN 100 In acute disease vial mg Horse, cattle—5-25 ml Cyanocobalamin (B12) Foal, calf—5-12 ml BP 50 mcg. Sheep, goat—2.5-5 ml Lamb, kid—1.5-2.5 ml To be repeated daily if required. In cases of chronic diseases 105 Inj. Catophos DO Half of the above dose is required, repeatedly at the intervals of 3-5 days. In healthy animals Half of the above dose. DO Inj. Navasol Inj. Metamax Vet Inj. BuphosVet Inj. Megasol DO DO Inj. Qmeat BC Vet Inj. Catoforce Inj. Metagen Inj. Metafos Inj. Acitol-B12 vet Bol. Metagen RENATA DO DO 30 ml, 100 ml vial DO DO DO DO DO SQUARE DO DO POPULAR DO DO 10 ml 30 ml 100 ml DO Each mL contains; Butaphosphan: 100 mg; Vit B12: 0.05 mg Taurin: 37.3 mg DL-Methionine: 18.7 mg Nicotinamide: 23 mg Each ml contains, Toldimphos Sodium: 200 mg, DO 50 ml, 100 ml ACI IM/SC route Cattle, Buffalo, Horse: 5-10 ml Calf, sheep, goat, Dog,Cat : 1-3 ml If needed repeat at intervals of 2-3 days until recovary Do DO DO CHEMIST Do 10 ml 100 ml Techno ACI 2 gm bolus CHEMIST 30 bolus in a pot ACI 30 gm, 100 gm sachet SK+F Do Each ml contains, Toldimphos Sodium: 200 mg, Cyanocobalamine (B12): 0.05 mg Each bolus contains, Toldimphos Sodium BP 2 gm Bol. I-Phos Each bolus contain, Elemental phosphorus25.81% Pulv. Qmeat BC Vet Each gram powder containsButaphosphan INN— 100 mg Vitamin B12—Enriched Cattle, Buffalo, Horse: 1-3 bolus daily, PO for 3-5 days. Calf, sheep, goat: ½ -1 bolus daily, PO for 3-5 days. Large animal: 1 bolus/ 50 kg bodyweight twicendaily for 7 days Small animal: ½ bolus/ 25 kg bodyweight twice daily for 7 days Cattle: 10-25 gm per animal in feed Navana Inepta SK+F 106 Vitamin + Mineral + Amino acid Indication: Milk fever, retained placenta, fertility increase, Milk and meat increaser, mineral deficiency, problem in hoof, agalactia, dysgalactia, after recovery from mastitis, during ketosis, to increase insulin production, to increase appetite & liver function, grass tetany, neonatal hypoglysemia. Contraindication: Hypervitaminosis, chronic diarrhea Trade Name Composition Dose Pack Size Company Pulv. Vitamin, Mineral 20-30 gm daily for 5-10 days 100 gm, Calfostonic Amino acid, Appetizer with rice gruel. 500 gm, 1 kg ACI Pulv. Ayumin Calcium + Phosphorus + Cattle, Buffalo, Horse: 30-50 1 kg Plus Zinc+ Cobalt + Copper + gm, PO for 10-15 days Iron + lodine + Calf: 10-15 gm,PO for 10-15 Magnesium + DLdays Methionine + L-Lysine Sheep, Goat: 7.5-10 gm, PO, for 10-15 days Pulv. Milk Multivitamins + Large animal (Cow, Buffalo): 1 kg Novartis boost Multiminerals 10-20 gm daily. Small animal (Goat, Sheep): 5-10 gm daily. Calf: 5 gm daily. Pulv. DCAD Dietary Anionic Cow & buffalo: 100-200 gm/ 1 kg Reneta minus Mineralsanimal daily for 3 weeks Magnesium sulphate— before parturition. 50% Aluminium sulphate— 32.5% Pulv. Pro-Mix Vitamin, mineral, amino For Dairy cow: 25-50 gm per 1 kg ACI Plus acid, dextrose day For meat production: 50-100 gm, twice daily Pulv. Availa 4 Zinc-5.15%, Manganese- For beef fattening and more 10 gm Renata 2.86%, Copper-1.80%, milk production100 gm Cobalt- 0.18%, Total 1 gm/30 kg BW daily. Amino Acid- 20.48% For goat: 1 gm daily. For horse: 1 gm/24 kg BW, daily. বড প্রাহি Pulv. Promone I2- 10 gm 100 gm ACI িু উৎ ািন বাডাটত্: ২০-২৫ গ্রাম Plus Casein- 90 gm 500 gm হিটন ১ বার ৭-১০ হিন। Fructo-oligosaccharideমাংস উৎ ািন বাডাটত্: ১৫-৩০ 20 gm গ্রাম হিটন ১ বার ৭-১০ হিন। Protein & Wheat- q.s ভছাে প্রাহি: ৫ গ্রাম হিটন ১ বার ৭-১০ হিন । Pulv. Vitamix ws vet Each 10 g contains Vitamin A 1000000 IU, Vitamin D3 250000 IU, Vitamin E 200 mg, Vitamin B1 120 mg, Vitamin B2 320 mg, Vitamin B6 120 mg, Calf: 5 g/calf daily. Goat & Sheep: 2.5 g/animal daily. 10 gm 100 gm sachet. Acme 107 Pulv. Nutri Gold Liq. Vitastar Bol. TMB Vet Vitamin B12 0.2 mg, Vitamin C 3000 mg, Vitamin K3 160 mg, Nicotinamide 200 mg, Pantothenic acid 184 mg, D-Biotin 1 mg Folic acid 10 mg. A Complete Tonic with Amino Acids, Vitamins, Minerals, Enzymes & Prebiotic Each 10 ml contains: Vitamin A—120,000 IU Vitamin D3—60,000 IU Vitamin E—15 mg Vitamin H (Biotin)—1.5 mg Vitamin C—10 mg Zinc—100 mg Cobalt—1 mg Selenium—1 mg Taurine—1,000 mcg Each bolus contains Copper-100 mg Cobalt-4 mg Manganese- 50 mg Zinc – 300 mg Iodine – 5 mg Iron – 100 mg Selenium – 1 mg 1 kg Popular For Oral Administration Cattle: 20 ml daily Calves: 5 ml daily Sheep & Goats : 5 ml daily 100 ml Square 1 bol/animal per day. 5×4 boli SK+F Milk Increaser Indication: Enhances milk production, fat contents and stimulates the growth of beneficial bacteria. Trade Name Composition Trade dose Pack Size Company Pulv. Milkex Lactobacillus sporogenes, 5-7 gm once daily for 100 gm Square Lactobacillus acidophilus, 10 days. container Saccharomyces cerevisae, Saccharomyces boulardii, Enzymes, Amino acids, Trace minerals, Fat soluble vitamins, Water soluble vitamins. Bol. Promilk Chelated minerals (Copper, Cattle/ Buffalo: 1-2 10x1’s Square Zinc) bolus per animal, Bolus once or twice daily. Sheep/Goat: ½ bolus 108 Bol. A-Milk Vet Bol. Milky Vet Jivanti (Leptadenia 109eticulate)—100 mg Teuri (Operculina turpethum)—500 mg Satamuli (Asparagus racemosus)—500 mg Aswagondha (Withania somnifera)—300 mg Bhumikus`mandu (Ipomea paniculata)—300 mg Shunthi/Ada (Zingiber officinale)—100 mg Niacin—1000 mg dl-Methionine—100 mg Ferrous Sulphate—20 mg Dicalcium phosphate—200 mg Each Bolus contains; Calcium2000 mg, Phosphorus-1000 mg, Vitamin A-50000 IU, Vitamin D-20000 IU, Vitamin E- 250 mg, Selenium-1 mg, Chromium propionate-2 mg, Biotin-150 mcg, Vitamin B12 150 mcg, Copper MHA-500 mg, Zinc MHA-1000 mg, Manganese MHA-500 mg, Leptadenia reticulate-1000 mg, Asparagus racemosus1000 mg, Yeast metabolites500 mg, Methionine activity (as HMTBA)-500 mg. per animal, once or twice daily. Cattle and Buffalo: 2-4 boli orally daily Large ruminants: 1-2 Bolus/ animal/ day Small ruminants: ½ Bolus/ animal/ day 10×2 bolus ACME 10X2 Boli SK+F Amino Acid (Amino acids, dextrose, electrolytes & vitamin B) Indication: Aminovit Plus Vet help in protein formation. It acts as building blocking agent for the development of meat production. It also use for the milk production. For use as a supplemental source of dextrose, electrolytes, vitamins and amino acids for all animals. Supporting therapy on the operation and after operation, convalescing, dehydration weakness, vomiting, diarrhea, imbalance of electrolytes, ketosis, anaphylaxis, acidosis and hypoproteinemia. Use in Pregnancy and Lactation: No ingredients in the product have been shown to produce reproductive effect. Safe in lactating period of animals. Trade Name Composition Trade dose Pack Company Size Inj. Aminovit Each 100 ml contains For Cattle, Buffalo, 20 ml Popular plus Vet Dextrose BP 5.0 g Horse, Goat, Sheep & vial Calcium Chloride BP 0.2 g other animals: 50 ml, Potassium Chloride BP 0.2 g 100 ml, Magnesium Sulphate BP 0.2 g Normal dose: 1 ml per 250 ml Sodium Acetate BP 0.75 g 10 kg body weight. 109 Inj. GainFast vet Inj. Aminomax Vet L-Histidine USP 0.002 g L-Methionine USP 0.0525 g L-Tryptophan USP 0.0175 g L-Cystine BP 0.002 g L-Threonine USP 0.035 g L-lsoleucine USP 0.0525 g L-Arginine USP 0.1425 g L-Phenylalanine USP 0.035 g L-Valine USP 0.0525 g L-Lysine Hydrochloride USP 0.0525 g L-Leucine USP 0.06 g Monosodium Glutamate USP 0.008 g Thiamine HCl (B1)—0.01 g Riboflavin (B2)—0.005 g Nicotinamide (B3) —0.3 g D-Pantothenol (B5)—0.01 g Pyridoxine HCl (B6)—0.01 g 5% Composite Amino Acid Solution with D-Sorbitol Each 100 ml injectable solution contains: L-Lysine -- 170 mg. L-Methionine -- 51 mg L-Threonine -- 78.2 mg, L-Tryptophan -- 34 mg, L-Arginine -- 142.5 mg, L-Leucine -- 187 mg L-Isoleucine -- 85 mg L-Valine -- 136 mg, L-Phenylalanine -- 119 mg, Glycine -- 375 mg, Sodium L-Glutamate -- 375 mg Thiamine HCl (B1)--10 mg, Riboflavin (B2)--5 mg. Nicotinamide (B3) --300 mg. Calcium Pantothenate (B5)--10 mg Pyridoxine HCl (B6)--10 mg. Cyanocobalamin (B12)- 5 mcg Sodium Acetate Trihydrate-750 mg. Calcium Chloride Dihydrate-200 mg, Potassium Chlonde -- 200 mg. Magnesium Chloride Hexahydrate --200 mg, Glucose -- 5000 mg Beef fattening dose: 2-4 ml per 10 kg body weight. Milk increaser dose : 2-4 ml per 10 kg body weight 500 ml bottle. Inject intramusculary, intravenously or subcutaneously. Do Do 100 ml 500 ml 50 ml 100 ml Vial Incepta Globe 110 Inj. Amitop-S Do Soln. Aminovit plus Vet Each 100 ml contains Dextrose BP 5.0 g Calcium Chloride Dihydrate BP 0.265 g Potassium Chloride BP 0.2 g Magnesium Sulphate Heptahydrate BP 0.410 g Sodium Acetate Trihydrate BP 1.244 g L-Histidine USP 0.002 g L-Methionine USP 0.0525 g L-Tryptophan USP 0.0175 g L-Cystine BP 0.002 g L-Threonine USP 0.035 g L-lsoleucine USP 0.0525 g L-Arginine USP 0.1425 g L-Phenylalanine USP 0.035 g L-Valine USP 0.0525 g L-Lysine Hydrochloride USP 0.0525 g L-Leucine USP 0.06 g Sodium Glutamate INN 0.008 g Riboflavin Sodium Phosphate BP 0.0095 g D-Pantothenol BP 0.01 g Pyridoxine Hydrochloride BP 0.01 g Nicotinamide BP 0.30 g Thiamine Hydrochloride BP 0.01 g Each 100 ml solution contains L-Lysine—1250.00 mg L-Methionine-500.00 mg L-Threonine-620.00 mg L-Tryptophan—90.00 mg Glycine—760.00 mg L-Histidine—250.00 mg LArginine—500.00 mg LAlanine—200.00 mg L-Aspartic acid—250.00 mg L-Cystine—10.00 mg L-Glutamic acid—75.00 mg L-Isoleucine—352.00 mg LLeucine—490.00 mg L-Phenylalanine—533.00 mg L-Proline—100.00 mg L-Serine—100.00 mg T-Tyrosine—25.00 mg Soln. Protimin Inject 1 ml per 5 kg of body weight 1-3 times a day SC/IM/IV. For Cattle, Buffalo, Horse, Goat, Sheep, Dog & other animals: 100 ml Gentry 100 ml, 500 ml & 1 Liter bottle Popular 100 ml SK+F Normal dose: 2-3 ml per 10 kg body weight in drinking water. Beef fattening dose : 4-6 ml per 10 kg body weight in drinking water. Milk increaser dose: 4-6 ml per 10kg body weight in drinking water. Cattle: 10-20 ml per animal daily 111 Susp. Vigest L-Valine—360.00 mg Manganese—1.6 mg Iron—4.00 mg Zinc—2.00 mg Macrominerals 0.5 g, B complex 1 g, Alanine 1.3 g, Arginine 0.6 g, Aspartic 1.8 g, Histidine 0.5 g, Isoleucine 1 g, Leucine 1.3 g, Lysine 1.6 g, Methionine 0.3 g, Phenylalanine 0.8 g, Proline 0.8 g, Serine 0.8 g, Threonine 0.8 g, Valine 1.2 g, Glutamic 2 g, Glycine 0.9 g Cattle and Horses : 60 – 100 ml Calves and Foals: 30 – 60 mL Lambs: 15 – 30 mL Small Animals: 2.5 – 5 mL As emergency food, repeat 4 – 6 hourly As a tonic or palatiser give with feed or as required. 500 ml Renata Liver tonics Mode of action: Acts on hepatocyte. Binds with toxicant present on sinusoidal spaces and excretes with urine or feces via bile. Indication: ✓ Helps in regeneration of liver ✓ Overcome deficiency of vitamin ✓ Increases function of liver in case of indigestion & infectious diseases ✓ Gives extra energy & repair liver immediately in case of infection when stored vitamins & energy sources are decreased. ✓ Choline chloride, vitamin- B12, liver extract, inositol prevent fatty change of liver. Sometimes remove excess fat from the liver. ✓ The B-vitamins are components of enzyme system, which needed for metabolism of carbohydrate, fat & protein. Trade Composition Dose Pack Size Company Name Liq. Liva vit Each Litre containsLarge Animal: 3-5 ml / 100 ml, SQUARE Vitamin B1--5,000 mg animal daily for 3-5 1L Vitamin B2--2,000 mg consecutive days. bottle Vitamin B5--11,000 mg Vitamin B6--2,000 mg Vitamin B12--10,000 mcg Vitamin K3--650 mg Folic Acid--300 mg Nicotinamide--60,000 mg Inositol--1,000 mg Cholin Chloride--50,000 mg DL-Methionine--50,000 mg Liver extract--200 mg Liq. Renaliv Livertonic Do 250 ml RENATA 500 ml 1L Liq. Choline chloride, yeast Cattle: 30 ml orally daily for 1 liter NOVARTIS Hepamin extract, Vit B1, B12, liver 5-7 days. forte 112 Liq. Hepatovet extract, niacin, DL-panthel, Innositol Goat, sheep: 15 ml orally daily for 5-7 days. প্রহত্ ১০০ হম. হল. ভত্ রটয়টছ- Livestock: 20-40 ml/ animal daily for 10-15 days. 500 ml, 1L ACME Cattle: 50 to 100 ml per head/day for 5 days. Horses: 50 ml per head/day for 5 days. Calves: 25 to 50 ml per head/day for 5 days. Sheep & Goat: 5 ml per head/day for 5 days. Do not exceed an administration longer than 10 days. General: 1-2 ml/10 kg bw 100 ml, 500 ml 1 Liter bottle. Acme 100 ml 500 ml ACI Livestock: 20-30 ml/animal for 5-7 days 100 ml, 500 ml, 1L POPULAR Cattle,buffalo -100 ml/animal 3-5 day. Goat,calf-30 ml/animal, 35day. Large animal: 100 ml daily Small animal: 50 ml daily 500 ml bottle RENETA 100 ml 1L SQUARE আফানাহমক্সিস হলস্টাহচয়া- ২০০ হম. গ্রা. োরহমনাহলয়া ভচবুলা- 800 হম. গ্রা. হরয়াম এটমাহি- ২৫০ হম. গ্রা. এনটরাগ্রাহফস ভ হনকুলাো- ২০০০ হম. গ্রা. বারটবহরস এহরসোো-800 হম. গ্রা. ও অনযানয ভেষজ উ ািান এবং হেোহমন হব১- ১৫ হম. গ্রা. হেোহমন হব- ৫. ৮ হম. গ্রা. হনটকাষ্টেনামাইি- ৮৪ হম. গ্রা. হেোহমন হব১২- ১০ হম. গ্রা. ইটনাহসেল- ২০০ হম. গ্রা. ভকাহলন বাইোরটেে- ৫ হম. গ্রা. Liq. Hepafit Vet Each ml contains Sorbitol-500 mg, Sodium (Chloride)-19 mg, Magnesium (Chloride)3.045 mg, Methionine hydroxy analogue-18.25 mg, Choline (Chloride)-80 mg, LCarnitine-25 mg, Betaine (HCl)-30 mg & Vitamin PP (B3)-2 mg. Liq. Hepa Amine Betain HCl: 60 gm Acetyl methionine: 100 gm Choline chloride: 75 gm D-Sorbitol: 350 gm L-Lysine: 20 gm Herb extract: qs to 1L Choline chloride, yeast extract, Vit B1, B6, B12, K, liver extract, niacin, DLpantothenic acid, inositol, folic acid Levocarnitine- 1 gm Choline chloride-3.5 gm Liq. Livaplex Liq Heparen Liq. Hepacef Gold (Liver tonic) Each 30 ml contains Silymarin-160 mg, Nicotinic Acid-20 mg, Nicotinamide-45 mg, Ferrous Gluconate-225 mg, Ferrous Chloride-80 mg, Thiamin Hydrochloride-7 mg, Riboflavine-7 mg, 113 Calcium Lactate-350 mg, Liver Fraction-2150 mg. Liq. Digestim (Natuaral Liver & Kidney Tonic) Liq. Toxol Soln. Restoliv Soln. Hepatonic Each 20 ml Digestim® Liquid containsVishamusti (Extract Nuxvomica ): 20 mg Bhringaraj (Extract Eclipta erecta): 25 mg Ela (Cardamom Powder): 25 mg Twak (Cinnamon Powder): 10 mg Methica (Fennel Powder) : 10 mg Peppermint Oil, Extract of Milk & etc.. Choline, Methionine, Inositol, Vitamin B12 in a base fortified with predigested protein, Aminonitrogen (Lipoacceptor Protein) and Liver extract. Each ml contains , Carnitine HCl- 25 mg DL-methionine- 10 mg Choline chloride- 18.75 mg Magnesium sulphate-10 mg Sorbitol (E420)- 200 mg Cynarine (antichoke extract)-5 mg Carriers and preservativesQS Each liter solution contains: Methionine 50.00 gm Choline Chloride 190.00 gm Inositol 2.50 gm Biotin 0.25 mg Vitamin B2 200.00 mg LA : 50 ml, 2 times daily. 100 ml, 1 litre SQUARE Fatty Liver Syndrome (Prevention): 15-20 ml per 100 birds for 3-5 days. Then 5 ml per 100 birds regularly or as directed by the Registered Veterinary Doctor. Treatment: 0.5-0.75 ml/ liter of drinking water for 57. Prevention: 1 ml/ liter of drinking water for 5-7. 100 ml & 1 Liter plastic bottle. Square 100 ml, 500 ml, 1L SK+F 500 ml, 1L, 25 kg 250 ml, 500 ml, 1L 100 ml, 500 ml, 1 Ltr 25 Ltr. ACI Should be given for 5-7 days by mixing with drinking water. Liq. Suprliv Herbal liver tonic Liq. Renaliv Herbal liver tonic Cattle, Horse: 20 – 50 ml in drinking water per day for 5 – 7 days. Sheep, Goats, and Calves: 5 – 10 ml in drinking water per day for 5 – 7 days Fish: 1-2 ml / kg feed 1 ml/L water 2 gm/kg feed 20 ml/ 100 kg Liq. Hepaton Vitamins, Pro-vitamin & Substances, Amino acids & their salts Large Animal: 20-30 ml in 1 Ltr. of drinking water for 57 days. OPSONIN 100 ml 500 ml, Renata AlMadina 114 Hematinic mixtures Mode of action: Haematinic mixture usually stimulates liver and bone marrow to produce blood. Indication: It acts as an effective appetite stimulant, for prevention and treatment of iron deficiency, anemia etc. This is also indicated in case of ruminal stasis resulting from metabolic and infectious diseases in cattle, buffaloes, sheep & goat. Contraindication: Diarrhoea, hypervitaminosis. Trade Name Generic Name Dose Pack Company Size Inj. Hemovit Each ml contains: intramus-cular or 10 ml RENATA Thiamine hydrochloride--75 intravenous route. 100 ml mg Riboflavin 5-phosphate Horse, Cattle, sodium—2 mg Buffaloes: 5 to 8 ml Pyridoxine hydrochloride--5 every 48 hours. mg Calves, Sheep & Niacinamide--100 mg goats: 2 to 3 mi d-Pantothenol--20 mg every 48 hours. Vitamin B12--120 mcg Ferric ammonium citrate— 15 mg Cobalt gluconate-0.70 mg Copper gluconate--0.20 mg Inj. V-plex vet plus Each ml contains IM route 10 ml, ACME Thiamine HCl (B1)--75 mg 100 ml Riboflavin (B2)--2 mg Cattle, Horse & vial Niacinamide (B3)--100 mg Buffalo: 5-8 ml D-Pantothenol (B5)-- 20 mg injection for every 48 Pyridoxine HCl (B6)--5 mg hours, 2-3 days. Cyanocobalamin (B12) 120 Calf, Goat & Sheep: mcg 2-3 ml injection for Ferric Ammonium Citrate-every 48 hours, 2-3 15 mg days. Cobalt Gluconate Ph. Grade--0.7 mg Copper Gluconate--0.2 mg Soln. Ferovet Each 100 ml contains, 1 ml/kg, PO, BID for 100 ml ACME Iron- 50 mg 5-7 days 500 ml Copper - 20 mg Cobalt - 10 mg Zn -20 mg B12 -10 mg Soln. Feromin Vet Do Do 500 ml Gentry Soln. HIMAFILL Each ml contains Ferrous Sulphate--0.5 mg, Copper Sulphate--0.2 mg Zinc Sulphate-- 0.2 mg Cobalt Sulphate--0.1 mg Vitamin B12 BP--0.1 mg Cattle: 1 mL / kg of body weight; twice a day 100 mL 500 mL Bottle. SK+F 115 Liq. ACI Foliron Plus (Vet) Elemental Iron-20 mg Cattle: 10-20 ml per 500 ml ACI Folate-100 mcg animal for 7-10 days Vitamin B1—10 mcg Vitamin with drinking water. B12—75 mcg Niacin—30 mg Flavour- q.s to 5 ml Iron dextran: Iron dextran is used in the treatment and prophylaxis of iron deficiency anemias, primarily in neonatal food-producing animals. Use in Pregnancy: High dosages may cause increased incidences of teratogenicity and embryotoxicity. Inj. Hempro-Vet Each ml contains, Adult Sheep, Goats 10 ml SQUARE Iron Hydroxide Dextran and Calf: 3-4 ml per Complex- 100 mg animal, IM. Cattle: 5-10 ml per animal, IM. Inj. Irondex Each ml Injection Solution Calves: 4-8 ml for 3-5 10 ml, Bridge contains-days intramuscularly. 50 ml Iron Dextran USP-100 mg Goats & Sheep: 4-5 100 ml. Cyanocobalamin (B12)-100 ml for 3-5 days mcg. intramuscularly. Cattle & Buffalo: 1015 ml for 3-5 days intramuscularly. Piglet (within first weeks of birth): 2 ml for 3-5 days intramuscularly (rump muscle). If necessary, repeat after 10 days. Electrolytes Mode of action: Increase the amount of necessary mineral and maintain electrolyte balance in the body. Indications: Diarrhoea, Toxemia, Calf Scour, Metabolic acidosis, Dehydration, Stress due to transportation, antibiotic therapy, electrolyte imbalance, mineral deficiency. Contraindication: Hypernatremia, Hyperkalemia, Glucoma, Sodium chloride poisoning Trade name Generic Name Dose Pack Size Company Pulv. Each Kg Electromin® Powder 1 gm / 2 Litre of 20 gm, SQUARE Electromin containsdrinking water 1 kg, Sodium bicarbonate BP - 500.0 or 20 kg gm 100 – 200 gm / 100 Sodium Chloride BP - 256.1 gm kg feed for 4-5 days. Pot. Chloride BP- 50.0 gm Dextrose BP- 180.0 gm Vitamin A- 1.0 gm Zinc sulphate BP- 7.9 gm Calcium Chloride BP- 2.5 gm Mag. Sulphate BP - 2.5 gm 116 Pulv. E-Lyte Electrolytes + Vitamin A + Dextrose Pulv. ElectroPlus In per kg – NaHCO3: 500 gm, Dextrose anhydrous: 175.04 gm, KCl: 50 gm, NaCl: 266 gm, Vit A: 2,000,000 IU, Vit D3: 500,000 IU Na, K, Mg, Ca, Zn, HCO3, Cl, Vit A, Dextrose Pulv. Eskalyte Pulv. Glucolyte Vet Each 25 g contains Sodium bicarbonate BP--12.5 g Sodium chloride BP--6.65 g Potassium chloride BP--1.25 g Vitamin A BP--50,000 IU Glucose anhydrous BP--4.50 g Pulv. Oralyte NaHCO3, KCl, NaCl, Vit A, Glucose Pulv. Acilyte 1 kg contains – NaHCO3: 500 gm; NaCl: 266 gm; KCl: 50 gm; Dextrose: 180 gm; Vitamin A: 2,000,000 IU DO In per kg – Dextrose Anhydrous + Potassium Chloride + Sodium Bicarbonate + Sodium Chloride + Vitamin A: 18 gm + 5 gm + 50 gm + 26.6 gm + 20 Lac IU Each 100 gm Powder containsSodium bicarbonate BP-50.0 gm Sodium Chloride BP- 26.6 gm Potassium Chloride BP- 5.0 gm Dextrose Anhydrous- 17.5 gm Vitamin A- 200000 IU Vitamin D3 - 50000 IU Sachet A: Glycine-31.8%,Nacl40.30%, Citric acid monohydrate-2.43%, Potassium citrate-0.6%, Potassium monophosphate-20.7%, Sachet B: dextrose monohydrate 100% Pulv. Renalyte Pulv. Dexolyte Pulv. Remelyte Pulv. ORT Calf 1.25 gm in 1 liter drinking water for 35 days or 3 gm in 1 kg feed for 3-5 days 1.5 gm/L water daily 1 gm/1.5-2 L water With water: 1.25 g GLUCOLYTE mixed with 1 L water for 3-5 days. With feed: 2 g mixed with 1 kg feed for 3-5 days. 2-4 gm/L water daily. 1 kg Popular 100 gm 500 gm, 1 kg, 25 kg TECHNO 500 gm, 1 kg, 20 kg 25 gm, 10 kg 20 kg SK+F ACME 25 gm, 500 gm, 1 Kg 1 kg OPSONIN DO 1-1.5 g powder mixed with 1 L water for 3-5 days. 1 kg 1 kg RENATA NAVANA 1.5 gm / 1 Litre of drinking water or 100 – 200 gm / 100 kg feed for 4-5 days 100 gm, 500 gm, 1 kg Bengal LR: 1.25 gm/L water Mix sachet A & B in 1 litre drinking water and give orally bid for 2-3 days 2 sachet per box9.72gm sachet A &22.31gm sachet B ACI RENETA 117 Fluid therapy (IV Infusion) Normal saline indications: (a) Vomition (b) Gastroenteritis. (c) Profuse sweating (d) Panting (Salivation) (e) Alkalosis (f) Pyloric obstruction (g) Abomasal impaction (h) Heat stroke Contraindication : (a) Oedematous condition (b) Ascites Dextrose (glucose) saline indications: (a) To correct water deficit (dehydration) (b) To maintain nutrition through parentral route in comatosed animal (10-25% solution) (c) To improve liver function (10 or 25%) in case of hepatitis and cirrhosis of liver. (d) To lower the Interstitial tissue pressure (50%). (e) To induce diuresis in case of physiological oliguria (50%) as in case of acute renal failure. (f) To treat hypoglycaemic coma. (g) To do glucose tolerance test. (h) To prevent tissue catabolism (i) To prevent ketosis. (j) To deplete liver glycogen Contraindication : Acidosis. Hartmann’s solution/Ringer's Lactate solution indications: Hartmann Solution is used to treat hypovolemia caused by surgery, hemorrhage and trauma. Excessive sweating, severe diarrhoea or vomiting, excess loss of fluid by nephrotic kidneys, inadequate intake of fluid and electrolytes etc. that may lead to typical hypovolemic shock may be corrected with Hartmann Solution. Severe plasma loss caused by intestinal obstruction, burns or other denuding conditions of the skin may be treated with Hartmann Solution. Hartmann Solution is mainly used as a fluid Contraindication : (a) Hepatic disorders (b) Anoxia due to shock (c) Congestive heart failure (d) Severe acidosis (e) Severe metabolic alkalosis (f) Rumen acidosis Cholera saline indications: Diarrhea, Vomiting, and fluid loss to replenish & restore the normal electrolyte balance of the body. Dosage of fluid therpy: {Thumb rule for Farm animal: 20 ml/kg based on 4-8% (mild) dehydration} {Thumb rule for Pet animal: 10-20 ml/kg based on 4-8% (mild) dehydration} Trade name Generic Name Dose Pack Size Company Normal saline Inj. Normasol Sodium chloride-0.9% ??? 100 ml, Libra (0.9%) (0.9 gm/100 ml) 500 ml, 1 L bag Inj. Normal Do Do Do Opso saline (NS) IV saline Inj. Acme’s Do Do Do Acme Normal saline Inj. Saloride IV Do Do Do Beximco Dextrose (5% , 10 % and 25%) 118 Inj. Acme’s Dextrose saline Inj. Dexaqua 5% Inj. Dextrose 5% Inj. Acme’s Dextrose DS Inj. Dexaqua DS Inj. Glucolin vet 25% Inj. Acme’s DNS Inj. DNS Inj. Glucohart IV Inj. Hartmann Solution (HS) Inj. Hartsol Inj. Lactoride Each 100 ml contains Dextrose Anhydrous 5.0 gm. Do ??? 500 ml, 1 L bag Acme Do Do Beximco Do Do Do Each 100 ml contains Dextrose Anhydrous 10 gm. Do ??? Do Opso saline Acme Do Do Beximco 500 ml, 1L Popular 500 ml, 1 L bag Acme Do Opso 500 ml, 1 L bag Popular 500 ml, 1L Acme Do Do Libra Beximco Each 100 ml solution contains Dextrose BP 25 gm Warm to body temperature and administer following dose slowly by intravenous or subcutaneous injection. Cattle and Horses: 200 ml to 1000 ml, Sheep and Goat: 60 ml to 200 ml, Depending on size and condition. Treatment may be repeated in several hours or on successive days as needed. Dextrose + Normal saline Each 100 ml ACME’s ?? Dextrose-N Saline contains Sodium Chloride BP 0.9 gm and Dextrose Anhydrous BP 5.0 gm. Do Do Dextrose + Hartmann's solution 5% dextrose & ??? hartmann's solution (sodium lactate, sodium chloride, potassium chloride, and calcium chloride) Hartmann's solution/ Ringer's Lactate solution Each 100 ml of ACME’s ??? Hartmann Solution contains Sodium Chloride BP 0.6 g, Potassium Chloride BP 0.04 g, Calcium Chloride BP 0.027 g and Sodium Lactate 0.32 g Do Do Do Do 119 Inj. Ringer's solution Inj. CS Inj. Koloride Inj. Kolosal Inj. Diasol Each 100 ml of Ringer's lactate solution containsSodium chloride-600 mg Anhydrous sodium lactate310 mg Potassium chloride-30 mg Calcium chloride dehydrate- 20 mg Cholera saline Each 100 ml of solution contains Sodium Chloride BP 0.5 g Potassium Chloride BP 0.1 g Sodium Acetate BP 0.393 g Do Do Do ??? 500 ml 1 L bag Opso Saline ??? 500 ml, 1L ACME Do Do Do Do Do Do Beximco Popular Libra Atropine preparations Mode of action: Inhibit the muscarinic receptor Generic dose: 0.02 to 0.04 mg/kg, IM/IV/SC but IM and IV routes are preferred for better uptake. Indication: ✓ to control excessive bronchial & gastric secretions, hypermotility of intestinal smooth muscle, secretory dirrhoea and excessive salivation ✓ as an antidote for organophosphate (insecticides) or muscarinic mushroom intoxication ✓ for treatment of bronchoconstrictive diseases. Contraindication: Heart failure, cardiomyopathy, glucoma, pre-existing tachycardia. Use in Pregnancy: not safe. Trade name Composition Dose Pack size Company Inj. Tropin vet Each ml injectable Treatment 10 ml ACME solution contains IM/SC use only. vial Atropine Sulphate Cattle/Horse: 1.5-3 ml/50 kg BP 1 mg body weight. Sheep/Goat: 0.8-1.6 ml/10 kg body weight. Pigs: 0.2-0.4 ml/10 kg body weight. Organophosphorus/Mushroom Poisoning 0.25-2.0 ml/10 kg body weight upto 5 ml/10 kg body weight subcutaneously. In severe cases, 1/4th of the dose to be administered by IV/IM and the remainder by SC. This dose can be repeated on an interval of 4 to 6 hours until clinical signs of poisoning relieved. Inj. Atrovet Do Do Do Techno 120 Haemostats Indication: External and internal haemorrhage. Generic dose: ✓ Tranexamic acid: 10 mg/kg BW, IM/IV/SC. ✓ Aminocaproic acid: 20 mg/kg BW Trade Composition Trade dose name Inj. Tracid Tranexamic acid: 100 IM/IV/SC route Vet mg/ml Cattle & Horse: 1 ml/4-20 kg body weight (5-25 mg/kg body weight). Human preparation Inj. Anaxyl DO 1 ml/10 kg BW, slow IV injection Inj. Enclot Inj. Hemosin Inj. Caprolex DO Aminocaproic acid: 1 gm/5 ml DO DO 1 ml/10 kg BW, single dose IV, orally, locally DO Vial size Company 10 ml vial Acme 5 ml ampoule DO 5 ml ACI Opsonin Chemist 5 ml, Techno Utero-tonic Indication: Timely expulsion of placenta, Early cessation of Lochia, Induction of heat, Regulation of estrus cycle and treatment of open pyometra, Maintain Uterine health, Helps in Early involution of Uterus, Helps to maintain the complicacy in times of calving, Helps to clean the uterus, Stimulate early milk let down in cow. Contraindication: Close cervix pyometra. Trade Composition Dose Pack Company Name Size Liq. Utoklin Each 5 ml contains extracts of Cattle, Buffalo: 450 ml Elanco the following – Timely Expulsion of bottle Guduchi & Vidanga- 5 mg placenta: 450 ml (single or Khair Chhal, Vata Chhai, Bilva, double dose) Amra Beej, Jasund, Sariva, Induction of heat: 54th day Bala Mool & Mocha Ras- 10 post of parturition 150 mg ml/day continue for 6 days. Amla, Baheda, Harde, Sheep/Goat: Bhringaraj & Lodhra- 20 mg Open pyometra: 150 ml/day Ashwagandha, Shatavari & for 6 days. Jambu Beej- 40 mg Timely expulsion of Dash Mool-100 mg placenta: 75 ml at 6hrs Deodar—150 mg interval Ashok Chhal—250 mg Syrupy Base—q.s n Sol . Each 100 ml contains For prevention of retained 500 ml Popular Utrofix Saraca indica-4 g placenta (ROP): 200 ml on Plumbago zeylanica-2 g day of calving followed by Bambusa arundinacea-4 g 100 ml for next 3 days Abroma augusta-5 g For the treatment of Peganum hermala-2 g Retention of Placenta Ruta graveolens-3 g (ROP): 500 ml orally at a 121 Claviceps purpurea-25 mg Sodium Selenate-3 mg Folic acid-12.25 mg Manganese sulphate-156 mg Ferrous sulphate-156 mg Tragacanth gum-500 mg Liq.U-Flush প্রহত্ ১০ হমহলটত্ থাটক ভেষজ হনযাস, ম অ হরিায ভত্ল, ম হেোহমন হি, হেোহমন ই এবং ভসটলহনয়াটমর সুষম সমন্বয় । time if needed repeat 500 ml after 6 hrs. For the treatment of pyometra/ repeat heat show/ timely induction of heat: Large animals: 200 ml on day one, followed by 100 ml daily for 3-5 days Small animals: 100 ml on day one, followed by 50 ml daily for 3-5 days Timely Expulsion of placenta: 25-50 ml, daily 710 days. For the treatment of Retention of Placenta (ROP): 500 ml orally at a time if needed repeat 500 ml after 6 hrs. Induction of heat: 54th day post of parturition 100 ml/day continue for 5 days. 500 ml ACI Detergents, Antiseptics & Disinfectants Indication: Disinfect livestock and Poultry’s living environment and appliances periodic. It also can be used in disinfection of livestock and poultry’s surgical part (skin mucous, the birth canal etc), surgical instruments, hatching egg and aquaculture. It is effective especially for Aftosa virus, Newcastle diseases, Avian influenza, Mycoplasma spp., State-run Influenza virus, PCV (Porcine circovirus), Eperythrozoon, Haemophilus parasuis, Pox viruses, Rabies and Streptococcus and Gill-rot diseases, Shrimp redbody diseases of aquiculture. Trade name Composition Dosage form Pack Company size Oint. Viodin Povidone Iodine--5% topical Apply to the affected 10 gm Globe area 2-3 times daily. Oint. DO DO 15 gm, Mundipharma Betadine Oint. Povin DO DO 10 gm Opsonin Soln. Povisep Povidone Iodine--10% topical Apply to the affected 100 ml, Jayson 10% area 2-3 times daily. 1L Soln. Povin DO DO DO Opsonin vet 10% Sol. Apodin DO DO DO Acme 10% Sol. Viodin DO DO DO Square Vet 10% Sol. Povet DO DO DO FnF Mouthwash. Povidone Iodine 1% Gargle or rinse with 100 ml Opsonin Povin 1% (Mouth-wash/Gargle) up to 10 ml for up to 30 122 Mouthwash. Povisep 1% Mouthwash. Viodin 1% Liq. Shift DO seconds without swallowing. Repeat up to four times daily for up to 14 consecutive days or as directed. DO DO Jayson DO DO DO Square Trisodium Nitrilo Triacetate For heavy soiling: Dilute 1:250 parts hot or cold water. For light soiling: Dilute 1:500 parts hot or cold water. For foam cleaning: Dilute 1:150 parts hot or cold water. 1L RENATA 100 ml, 1 L , 5 L, 25 L 100 ml, 500 ml, 1L, RENATA Spray: 3 ml/1L Foot bath: 12 ml/1L Water:1 ml/5L 100ml 1L 20L ACI Mix 3.5 to 14.1 ml per liter and sanitize. 100 ml, 1 Liter &1 Gallon pack. 100 ml 1L Square Liq. FAM 30 Iodin, Non Ionic Surfectant, Sulfuric Acid, Phosphoric Acid Liq. GPC-8 Soln. Bioclean plus Gluteraldehyde --25.483%, Quarternary ammonium-9.686%, Non-ionic surfactant-7.995%, Phosphoric acid-1.081% 2 Quaternary ammonia: ammonium chloride: 170.6 g/L, Glutaraldehyde: 107.25 g/L, Pine oil: 20 g/L, Buffering agent and Stabilizer Glutaraldehyde--14.0% Alkyl (C14 50%, C12 40%, C16 10%) dimethyl benzyl ammonium chloride--2.5% Inert Ingredients--83.5% Gluteraldehyde: 15% Benzyl conium: 10% Soln. Povidon Vet Povidon Iodine 10% USP Solution Soln. Virocid Soln. GlutexGQ Spray: 5 ml/L Disinfection: 2.5 ml/1L, 300 ml/sq.m Footbath: 10 ml/1L For dairy and poultry apparatus: 5-10 ml/1L As antiseptics: 5 ml/1L Cattle: Udder disinfection: 4 mL/liter water Water disinfection: 68 mL/liter water 100 mL, 500 mL 1L Renata Chemist SK+F 123 Pulv Greencop Pulv. Farm Care Potassium monopersulphate 500gm, malic acid 100 gm, sulphuric acid 50 gm, NaCl 15 gm, Na hexametaphosphate 181 gm, Na dodecyl benzene sulphonate-150 gm Oxidol 8% Nacolite-10 % 100 gm/20 litre water or 5 gm/lit water 10 gm, 100 gm, 1 kg ACI সযাহনোইক্সজং ভমটে, হফিার এবং াহনর াত্র প্রহত্ হলোর াহনটত্ ২০ গ্রাম এবং হনয়হমত্ ফাম ম ভে ১০ গ্রাম প্রহত্ হলোর াহনটত্ হমহিত্ কটর বযবিার করটত্ িটব। 100 gm ACI Homeopathic drugs used in veterinary medicine Trade name Liq. Cantharis Indication Urolithiasis Liq. Cal-carb-200 Urolithiasis Liq. Acon-plus Urinary tract infection Tetanus Liq. Hypericum200 Liq. Armica-200 Trade Dose Take 3-5 drops of dilution in half cup of water three times a day 8-10 drops mixed with 2 tea spoon water and administer orally 6-8 hours interval 2-4 tea spoon mixed with equal amount of water and administer orally at 2-3 hours interval 7-8 drops with cotton at nose 2 times daily Liq. Thuja Urinary bladder infection, Uncontrolled urination Papillomatosis 6-7 drops mixed with ¼ cup of water and administer orally once daily Liq. Mercsol Actinomycosis Liq. Acid Nitritum-200 Liq. Phytolocca200 FMD 1 ml mixed with 1ml water administer orally twice daily for 2-3 days 4-5 drops mixed with ½ cup of water and administer orally three times daily Twice daily Mastitis 1 dose 2 hours interval, 4-5 dose for 2-3 days (For more information, search google) Dairy tools Indication: For diagnosis of clinical and subclinical mastitis of milking animal. Trade name Composition Pack size Test procedure CMT Sodium dodecyl 200 ml After washing of udder collection of 2 ml milk Test kid Benzosulfonate: reagent from each quarter within the cup of test paddle (ACI) 30 gm, and 1 test separately. Then add 2 ml reagent in each test Bromocrysol paddle cup. Then gently rotate the test paddle for 10-15 purple: 0.1 second. Result or interpretation: If any cup reagent and milk found in liquid mixing condition. It indicates no infection. If color of the milk becomes slightly purple, it indicates that mild infection present and milk is basic in nature. 124 If color of the milk becomes yellow in color, it indicates infection present and milk is acidic. If there is any gel formation in test kid, it indicates confirm presence of infection in udder. 125 Pet Animal Medicine (Dog, Cat) A handy list of the top toxic people foods to avoid feeding your pet 1 Alcohol beverages 2 Onions, Garlic, Chives 3 Apple seeds 4 Raw/Undercooked Meat, Eggs and Bones 5 Apricot pits 6 Salt and Salty Snack Foods 7 Hops (used in home beer brewing) 8 Xylitol 9 Cherry pits 10 Yeast Dough or Moldy foods 11 Gum 12 Mushroom plants 13 Avocado 14 Mustard seeds 15 Chocolate (Candy) 16 Peach pits 17 Coffee (grounds, beans, and 18 Potato leaves and stems (green parts) chocolate-covered espresso beans) 19 Caffeine 20 Rhubarb leaves 21 Citrus 22 Salt 23 Coconut and Coconut Oil 24 Tea (because it contains caffeine) 25 Grapes and Raisins 26 Tomato leaves and stems (green parts) 27 Macadamia Nuts 28 Walnuts 29 Milk and Dairy products 30 Nuts Note: This is not an exhaustive list; any decision to provide your pet with food not specifically intended for animals should be discussed with your pet’s veterinarian or a board certified veterinary nutritionist. See toxic plants for pets: https://www.aspca.org/pet-care/animal-poison-control/toxic-and-nontoxic-plants Reference: 1. American Society for the Prevention of Cruelty to Animals: https://www.aspca.org/petcare/animal-poison-control/people-foods-avoid-feeding-your-pets 2. The Humane Society of the United States: https://www.humanesociety.org/resources/plants-andfood-can-be-poisonous-pets 126 Antibiotics Penicillins Procaine penicillin G + Benzathine penicillin G (Natural penicillins) Generic dose: Penicillin G procaine: 20,000–40,000 Units/kg IM, SC q12–24h for as long as necessary. Penicillin G benzathine: 50,000 Units/kg IM q5 days. Indication: Prototypical penicillin agent used for susceptible gram-positive aerobes & anaerobes; best used parenterally. Use in Pregnancy: safe for use in pregnant and in lactating animals. Trade name Composition Trade dose Pack size Company Inj. Bipen-Vet 40 Each vial contains Procaine 0.5-1 ml/10 kg, BW, 40 lac vial SQUARE Penicillin- 30,00,000 IU and IM, q24h, 3-5 days. + 10 ml Benzyl Penicillin SodiumWFI 10,00,000 IU. Inj. Combipen vet Do Do Do Acme 40 Lac Inj. Pronapen vet Do Do Do Renata 40 Lac Inj. Duplocillin LA Procaine penicillin 150,000 1 mL/10 kg 100 mL MSD IU per mL. Benzathine bodyweight SC or bottle Animal penicillin 150,000 IU per mL. IM Health (as 30,000 IU/kg). Injection may be repeated at 72 hour intervals depending on clinical judgment given at a different injection site. Amino-penicillin: Ampicillin (Broad-spectrum penicillins) Generic dose: 10–30 mg/kg q6–8h IV/IM/SC, or 20–40 mg/kg q8h PO. Indication: A large number of gram-positive and gram-negative bacteria (but not beta-lactamase– producing strains) are sensitive to the semisynthetic broad-spectrum penicillins (ampicillin and amoxicillin). Susceptible genera include Staphylococcus, Streptococcus, Trueperella, Clostridium, Escherichia, Klebsiella, Shigella, Salmonella, Proteus, and Pasteurella. The aminopenicillins are inactive against Rickettsia, mycobacteria, fungi, Mycoplasma, and viruses. Use in Pregnancy: is safe during pregnancy & lactating period. Trade name Composition Trade dose Pack size Company Inj. Ampicin Each vial contains 0.5-1.0 ml/ 10 Kg BW, 2 gm vial + 10 Square vet Ampicillin Sodium 2.0 once daily but in severe ml ampoule gm/vial infection twice daily. WFI. Inj. Acipilline DO DO DO ACI vet Human preparation Cap. Acmecilin Ampicillin Sodium: 1 cap for 10 kg bwt, PO 250 mg Acme 250 250 mg (as 25 mg/kg) capsule 127 Susp. Acmecilin Ampicillin Sodium: 25 mg/ ml 1 mL per kg bwt, PO. (as 25 mg/kg) 100 ml bottle Acme Amino-penicillin: Amoxicillin (Broad-spectrum penicillins) Generic dose: 10-30 mg/kg BW, bid, PO/SC/IV/IM. Indication: same as Ampicillin . Use in Pregnancy: is safe during pregnancy & lactating period. Trade name Composition Trade dose Pack size Inj. Moxacil Vet Amoxicillin 1 ml/10 kg, IM/SC, For 1 gm vial with Sodium-1 gm 3-5 days. 10 ml Water for (as 10 mg/kg) Injection. Inj. Acimox Vet Do Do Do Inj. Fimox vet Do Do Do Human preparation Cap. Moxacil Amoxicillin: 250 1 capsule for 10 kg 250 mg mg (as 25 mg/kg) capsule Cap. Tycil Do Do Do Cap. SK-Mox Do Do Do Cap. Moxacil Amoxicillin: 500 1 capsule for 20 kg 500 mg capsule mg (as 25 mg/kg) Cap. Tycil Do Do Do Cap. SK-Mox Do Do Do Susp. Moxacil Amoxicillin: 25 1 ml/kg, PO, Bid. 100 ml bottle mg/ml (as 25 mg/kg) Susp. Tycil Do Do Do Susp. SK-Mox Do Do Do Paediatric drops. Amoxicillin: 125 5 drops/kg bwt, Bid. 15 ml bottle SK-Mox mg/1.25 ml (as 25 mg/kg) Paediatric drops. Do DO Do Tycil Paediatric drops. Do Do Do Moxacil (Here, 1 ml= 20 drops. So, 1.25 ml= 25 drops.) Company Square ACI Popular Square Beximco SK+F Square Beximco SK+F Square Beximco SK+F SK+F Beximco Square Potentiated aminopenicillin: Amoxicillin + clavulanic acid (Broad-spectrum penicillins) Generic dose: 10–25 mg/kg, PO, q8-12h. Indication: For the treatment of urinary tract, skin and soft tissue infections caused by susceptible organisms. Use in pregnancy: The safety of administration of Amoxicillin and clavulanic acid to pregnant or breeding animal is unknown. Trade name Composition Trade dose Pack size Company Inj. Augment Each pack contains, 1 mL / 28 Kg body weight, 1.2 gm vial + SK+F Vet 1.2g Amoxicillin sodium 1 by IM/SC, once daily for 310 mL WFI g & Clavulanic Acid 5 days. 200 mg/ vial (as 7 mg/ Kg) Or 128 Inj. Moxaclav 1.2g 1 ml/10 kg BW, IM/SC, once daily for 3-5 days. (as 12 mg/kg) Do Do Human preparation Susp. Augment Amoxicillin sodium + 1 ml/2 kg, PO, bid, for 3-5 Clavulanic Acid- (125 days. mg + 31.25 mg) / 5 mL (as 15 mg/kg) Susp. Moxaclav Do Do Susp. Tyclav Do Do Tab. Tyclav Amoxicillin sodium + 1 tab/ 15 kg bw. Bid, PO. Clavulanic Acid- 250 mg + 125 mg (as 25 mg/kg) Tab. Avloclav Do Do 375 mg Tab. Moxaclav Do Do 375 Do Square 100 ml SK+F Do Do 250 mg +125 mg tablet Square Beximco Beximco 375 mg tablet Do ACI Square Cephalosporins Indication: These antibiotics are used in the treatment of respiratory, skeletal, genitourinary, skin and soft tissue infections. In addition, these drugs are recommended for prophylactic use in biliary tract surgery and for treating biliary tract disease. All are effective against anaerobic infections except Bacteriodes fragilis (cefoxitin excepted). Adverse and common side effects: Vomiting and diarrhoea may occur with oral administration. Administration with food decreases nausea. Because most cephalosporins are eliminated by the kidney, their concentration is increased and their half life is extended in cases of renal failure. All parenteral forms may cause phlebitis and myositis after IV or IM injection, respectively. Hypersensitive reactions like acute anaphylaxis, allergic agranulocytosis, fever, serum sickness, diarrhoea, thrombocytosis etc. Drug interaction: The cephalosporin antibiotics are potentially nephrotoxic and it is advised that these drugs be used with caution when administered concurrently with other potentially nephrotoxic drugs, eg. Aminoglycosides (Gentamicin, Kanamycin, Neomycin & Streptomycin), Amphoteracin B, Vancomycin, Polymixin B or a Diuretic like Frusemide. Use in Pregnancy & lactation: safe. First-generation Cephalosporins First-generation cephalosporins include cephaloridine, cephapirin, cefazolin, cephalexin, cephradine, and cefadroxil. Cephalosporins in this group are usually quite active against many grampositive bacteria but are only moderately active against gram-negative organisms. They are ineffective against Enterococcus spp, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus. Susceptible gram-negative bacteria include Escherichia coli and Proteus, Klebsiella, Salmonella, Shigella, and Enterobacter spp. Cefazolin is more effective against E coli than cephalexin, to which it is minimally susceptible. Although generally less susceptible to beta-lactamase destruction than penicillins, cephalosporins are susceptible to cephalosporinases and are not as effective against anaerobes as are the penicillins. Cefazolin sodium 129 It is used for surgical prophylaxis, and for a variety of systemic infections (including orthopaedic, soft tissue, sepsis) caused by susceptible bacteria. Most commonly given every 6–8 hours. Potentially could cause hypersensitivity reactions. Can cause pain on IM injection; Give IV over 3–5 minutes (or more). May need to reduce dose in renal failure via parenteral routes. Generic dose: 10–30 mg/kg, IV/IM/SC, q8h. Trade name Composition Trade dose Pack size Company Inj. Zolibac Cefazolin sodium-1 1 ml/ 10 kg BW,IM/IV, 1 gm vial + 5 mL square IM/IV gm/vial q8h. WFI (as 20 mg/kg) Inj. Zolibac Cefazolin sodium1 ml/ 5 kg BW,IM/IV, 500 mg vial + 5 square IM/IV 500 mg/vial q8h. mL WFI (as 20 mg/kg) Cephalexin Generic dose: Dog: 10–30 mg/kg q6–12h, PO Cat: 20–50 mg/kg q12h, PO Trade name Composition Trade dose Susp. Selex Cephalexin- 25 1 mL per kg bwt, PO, q12h, mg/ml (as 25 mg/kg) Susp. Acelex DO DO Cap. Acelex Cephalexin- 250 mg 1 capsule for 10 kg, PO (as 25 mg/kg) Cap. Selex DO DO Paediatric Cephalexin-125 5 drops/kg bwt, Bid. drops. Acelex mg/1.25 mL (as 25 mg/kg) (Here, 1 ml= 20 drops. So, 1.25 ml= 25 drops.) Pack size 100 ml Company Orion DO 250 mg capsule DO 15 ml bottle Acme Acme Pack size 100 ml bottle Company Incepta DO 500 mg capsule SK+F Incepta DO 15 ml bottle SK+F SK+F DO Incepta Orion Acme Cefadroxil Generic dose: Dog-22–35 mg/kg q12h, PO Cat- 22–35 mg/kg q24, PO Trade name Composition Trade dose Susp. Adora Cefadroxil 1 mL per kg bwt, PO, q12h, monohydrate- 25 mg/ml (as 25 mg/kg) Susp. Arocef DO DO Cap. Adora Cefadroxil 1 capsule for 20 kg, PO monohydrate- 500 mg (as 25 mg/kg) Susp. Arocef DO DO Paediatric Cefadroxil 5 drops/kg bwt, Bid. drops. Arocef monohydrate--125 (as 25 mg/kg) mg/1.25 mL Paediatric DO DO drops. Adora (Here, 1 ml= 20 drops. So, 1.25 ml= 25 drops.) Second-generation Cephalosporins in Animals Second-generation cephalosporins include cefamandole, cefoxitin (a cephamycin), cefotiam, cefaclor, cefuroxime, and ceforanide. These agents are generally active against both gram-positive 130 and gram-negative bacteria. Moreover, they are relatively resistant to beta-lactamases compared with first-generation drugs. They are not effective against Enterococcus spp, Salmonella spp, methicillin-resistant Staphylococcus spp, P aeruginosa (with the frequent exception of cefoxitin), Actinobacter spp, and many obligate anaerobes (again, cefoxitin is an exception). Cefaclor Generic dose: Dog, cat: 10–20 mg/kg q8h PO Composition Trade dose Cefaclor 1 mL per 2 kg bwt, PO, q8h, monohydrate- 25 mg/ml (as 12.5 mg/kg) Susp. Alclor DO DO Cap. Abaclor Cefaclor 1 capsule for 25 kg, PO, q8h, monohydrate-250 mg (as 10 mg/kg) Cap. Biocef DO DO Paediatric Cefaclor 4 drops/kg bwt, Bid. drops. Alclor monohydrate--125 mg/1.25 mL (as 20 mg/kg) Paediatric DO DO drops. Ceflon (Here, 1 ml= 20 drops. So, 1.25 ml= 25 drops.) Trade name Susp. Abaclor Pack size 100 ml bottle Company ACI DO 250 mg capsule DO 15 ml bottle Acme ACI DO Novartis Acme SK+F Cefuroxime axetil / Cefuroxime sodium Generic dose: Dog: 10–30 mg/kg q8-12h PO/IV. For surgery prophylaxis: 20 mg/kg IV 30 minutes prior to surgery and every 2 hours during surgery. Trade name Composition Trade dose Pack size Company Inj. Cefotil Each vial contains 1 ml/ 3 kg BW, IV, q8-12h. 750 mg square 750 mg Cefuroxime sodium(as 25 mg/kg) vial + 10 750 mg mL WFI Susp. Furocef Cefuroxime Axetil -25 1 mL per kg bwt, PO, q12h, 70 mL Renata mg/ml (as 25 mg/kg) Susp. Cefotil DO DO DO square Tab. Zerotil Cefuroxime Axetil-250 1 tablet for 10 kg, PO, q12h 250 mg Beacon 250 mg mg (as 25 mg/kg) tablet Tab. Cefotil DO DO DO square 250 mg Third- and Fourth-generation Cephalosporins The third-generation cephalosporins include ceftiofur, ceftriaxone, Cefixime, cefotaxime, cefoperazone and several others, including cefpodoxime and cefovecin, approved for use in dogs and for use in dogs and cats, respectively. Cefepime is a fourth-generation cephalosporin. The spectrum of third- and fourth-generation cephalosporins varies and should be confirmed based on bacteriologic culture and antimicrobial susceptibility testing before use. The spectrum of veterinary third-generation cephalosporins should not be considered extended in that efficacy often does not include Pseudomonas or other problematic coliforms. Ceftiofur is a third-generation cephalosporin with a gram-negative spectrum that is more similar to that of first-generation cephalosporins. Ceftiofur has been specifically approved for use in cattle with bronchopneumonia, especially if due to Mannheimia haemolytica or Pasteurella multocida. Although it is approved for use in dogs to treat urinary tract infections (injectable), other more convenient 131 drugs are generally used. Cefpodoxime and cefovecin are particularly effective against Staphylococcus pseudintermedius, yet retain fair efficacy toward gram-negative organisms such as E coli, Klebsiella, and Proteus. Some drugs approved for use in people have only moderate activity against gram-positive bacteria (again, enterococci are resistant) but have extensive activity against a wide variety of gram-negative bacteria, including Pseudomonas spp, Proteus vulgaris, Enterobacter spp, and Citrobacter spp (eg, cefotaxime and ceftazidime). Third- and fourth-generation cephalosporins were designed to be increasingly resistant to beta-lactamases. However, differences in chemical structure have been overcome by the formation of extended-spectrum beta-lactamases that target third- and fourthgeneration drugs (but not, as a general rule, cephamycins). Cefixime Generic dose: 5–12.5 mg/kg PO q12-24h. Trade name Composition Trade dose Susp. Cef 3 Cefixime trihydrate: 1 ml/ 4 kg BW, PO, q12h. 720 mg/ml 14 days. (as 5 mg/kg) Susp. Roxim DO DO Susp. Fix A DO DO Tab. Ceftid Tab. Cef 3 Tab. Roxim Paediatric drops. Fix A Paediatric drops. Cef 3 Paediatric drops. Cefim3 Cefixime trihydrate: 200 mg DO DO Cefixime trihydrate: 25 mg/ml DO 1 tablet for 20 kg, PO, q12h (as 10 mg/kg) DO DO 4 drops/kg bwt, Bid. (as 5 mg/kg) DO DO DO Pack size 30, 50 , 75 ml bottle Company Square DO 40, 50, 75 ml bottle 200 mg tablet DO DO 21 ml bottle SK+F Acme Opsonin Square SK+F Acme DO Square DO ACI Pack size 250 mg vial + 5 WFI Company Square DO DO DO ACI Renata Incepta (Here, 1 ml = 20 drops.) Cefotaxime Generic dose: 20-80 mg/kg bwt, IM/IV, q6h. Trade name Composition Trade dose Inj. Maxcef Cefotaxime: 250 1 vial for 5 kg BW, IM/IV, mg/vial q6h. (as 50 mg/kg) Inj. Cefot DO DO Inj. Cefotax DO DO Inj. Cefotime DO DO Cefpodoxime Generic dose: 5–10 mg/kg, q12h, PO, for 5–7 days or 2–3 days beyond cessation of clinical signs, up to a maximum of 28 days. Indications: In dogs, cefpodoxime is indicated for the treatment of skin infections caused by Staphylococcus intermedius, Staphylococcus aureus, Streptococcus canis, E. coli, Proteus mirabilis, and Pasteurella multocida. Trade name Composition Trade dose Pack size Company 132 Susp. Cefdox Cefpodoxime proxetil-40 mg/5 ml Susp. CP Susp. Pedicef Tab. CP DO DO Cefpodoxime proxetil200 mg Tab. Cefdox Tab. Rovantin Paediatric drops. Pedicef PD DO DO Cefpodoxime proxetil20 mg / ml Paediatric drops. CP Paediatric drops. Cefdox DO DO 1 ml/ kg BW, PO, q12h. 5-7 days. (as 8 mg/kg) DO DO 1 tablet for 20 kg, PO, q12h (as 10 mg/kg) DO DO 10 drops/ kg bwt, Bid. 50 ml bottle ACI DO DO 200 mg tablet Acme Orion Acme DO DO 15 ml bottle ACI Opsonin Orion DO DO Acme DO DO ACI (as 10 mg/kg) (Here, 1 ml = 20 drops.) Ceftriaxone Generic dose: 25–50 mg/kg IV/IM or Intraosseous q12h as long as necessary. Trade name Composition Trade dose Pack size IM preparation Inj. Triject vet Ceftriaxone sodium: 1 ml/5 kg BW, deep IM, sid- 500 mg vial + 500 mg/vial bid for 3-5 days 2 mL 1% (as 50 mg/kg) Lidocaine HCL Inj. Trizon Vet DO DO DO Inj. ACICEF-3 (vet) Inj. Triject vet Company SK+F Acme DO DO DO ACI Ceftriaxone sodium: 1 gm/vial Do SK+F Inj. Trizon Vet Do 3.5 ml/ 20 kg BW, deep IM, sid-bid for 3-5 days (as 50 mg/kg) Acme Inj. ACICEF-3 (vet) Inj. Bovixon Vet Inj. Triject vet DO DO 1 gm vial + 4 mL 1% Lidocaine HCL 1 gm vial + 3.5 mL 1% Lidocaine HCL DO Do Do Do Incepta Ceftriaxone sodium: 2 gm/vial 1 ml/5 kg BW, deep IM, sidbid for 3-5 days (as 50 mg/kg) SK+F DO 7 ml/ 40 kg BW, deep IM , sid-bid for 3-5 days 2 gm vial + (4+4) mL 1% Lidocaine HCL 2 gm vial + 7 mL 1% Inj. Trizon Vet ACI Acme 133 (as 50 mg/kg) Inj. ACICEF-3 (vet) Inj. Bovixon Vet DO DO Lidocaine HCL DO Do Do Do Incepta Inj. Triject vet Ceftriaxone sodium: 500 mg/vial 500 mg vial + 5 mL WFI SK+F Inj. Trizon Vet DO DO Acme Inj. Triject vet Ceftriaxone sodium: 1 gm/vial DO 1 gm vial + 10 mL WFI DO SK+F Inj. Trizon Vet IV preparation 1 ml/ 2 kg BW, IV slowly, sid-bid for consecutive 3-5 days. (as 50 mg/kg) DO Do DO Inj. Triject vet Ceftriaxone sodium: 2 gm/vial Do Inj. Trizon Vet Do Inj. ACICEF-3 (vet) DO ACI Acme Do 2 gm vial + (10+10) mL WFI Do SK+F Acme DO DO ACI Ceftiofur Generic dose: 2.2–4.4 mg/kg, SC, q12–24h. Indication: In dogs for the treatment of canine urinary tract infections associated with E. coli and Proteus mirabilis. Trade name Composition Trade dose Pack size Company Inj. Dedicef Each vial contains 1 ml/23 kg BW,SC, once, 0.5 gm vial + SK+F vet Ceftiofur Sodium sterile for 5-14 days 10 mL WFI powder 0.5 g (as 2.2 mg/kg) Inj. Tifur vet DO DO DO Acme Inj. Dedicef Each vial contains DO 1 gm vial + SK+F vet Ceftiofur Sodium sterile 20 mL WFI powder 1 g Inj. Tifur vet DO DO DO Acme Cefepime Generic dose: 40–50 mg/kg, IV/IM, q6–8h. Indication: Injectable 4th generation cephalosporin that is more active against some gram negative & gram-positive bacteria than 3rd generation cephalosporins. Limited clinical experience in veterinary medicine. Treatment may be very expensive. Trade name Composition Trade dose Pack size Company Inj. Cefa 4 Cefepime Hydrochloride1 ml/2 kg, BW, IV, 500 mg IV vial Popular 500 mg/vial q6h + 5 mL WFI (as 50 mg/kg) Inj. Maxpime DO DO DO square Inj. Cefa 4 Cefepime Hydrochloride-1 Do 1 gm IV vial + Popular gm/vial 10 mL WFI Inj. Maxpime DO DO DO square 134 Inj. Cefa 4 Cefepime Hydrochloride500 mg/vial 1.3 ml/10 kg, BW,IM, q6h. (as 50 mg/kg) 1.5 ml/10 kg, BW,IM, q6h. (as 50 mg/kg) 500 mg IM vial + 1.3 mL WFI Popular Inj. Maxpime DO 500 mg IM vial + 1.5 mL WFI square Inj. Cefa 4 Cefepime Hydrochloride-1 gm/vial 2.4 ml /20 kg, BW,IM, q6h. (as 50 mg/kg) 1 gm IM vial + 2.4 mL WFI Popular Inj. Maxpime DO 3 ml/20 kg, BW,IM, q6h. (as 50 mg/kg) 1 gm IM vial + 3 mL WFI square Fluoroquinolones The fluoroquinolones are active against a wide range of gram-negative organisms and several grampositive aerobes. These include E coli, Salmonella, Klebsiella, Enterobacter, Proteus, and generally P aeruginosa. The fluoroquinolones are active against intracellular pathogens, including Brucella spp. Quinolones also have substantial activity against Mycoplasma, Rickettsia, and Chlamydia spp. Obligate anaerobes tend to be resistant to most quinolones, as are most enterococci (formerly group D Streptococcus spp, Enterococcus faecalis, and Enterococcus faecium). Nocardia and atypical mycobacteria may also be susceptible. Ciprofloxacin has the greatest activity against Pseudomonas spp, whereas enrofloxacin has lower MICs for gram-positive bacteria. Although enrofloxacin has evidence of in vitro susceptibility to Pseudomonas spp, resistance develops rapidly in clinical strains, and therefore it is unlikely to be effective. The newer third- and fourth-generation fluorinated quinolones (eg, pradofloxacin) are often characterized by an effective anaerobic spectrum. A synergistic effect has been demonstrated in vitro between quinolones and beta-lactam antimicrobials, aminoglycosides, clindamycin, and metronidazole. Pregnancy: because of the risks of cartilage abnormalities in young animals, the fluoroquinolones are not generally recommended for use during pregnancy unless the benefits of therapy clearly outweigh the risks. Ciprofloxacin Generic dose: 5–15 mg/kg PO q12h, PO/IV. Indication: Ciprofloxacin is indicated for Respiratory Tract infections, Gastro Intestinal infections, Enterotoxaemia, Skin Bone & Ear infections. Trade name Composition Trade dose Pack size Company Inj. Ciprocin- Each ml injection contains 1 ml/10 kg body weight, 10 ml, Square Vet Ciprofloxacin BP 50 mg. IM/IV, daily for 3-5 days 50 ml (as 5 mg/kg b.wt.) Vial. Inj. Beuflox DO DO DO Incepta Vet Inj. Cipro-A DO DO 30 ml, ACME Vet 100 ml Human preparation Inj. Ciprocin Each ml injection contains 2.5 ml/ kg body weight, IV, 100 mL Square (IV Infusion) Ciprofloxacin 2 mg. daily for 3-5 days vial (as 5 mg/kg b.wt.) 135 Inj. Civox (IV Infusion) In. Cipro-A (IV Infusion) Tab. Ciprocin 250 mg Tab. Cipro-A 250 mg Tab. Ciprox 250 mg Susp. Ciprocin Susp. Ciprox DS Susp. Civox DO DO DO Popular DO DO DO ACME Ciprofloxacin: 250 mg 250 mg tablet DO Square DO 1 tablet for 25 kg, PO, q12h (as 10 mg/kg) DO DO DO DO Opsonin Ciprofloxacin: 50 mg/ ml 60 ml bottle Square DO 1 ml/ 5 kg BW, PO, q12h. 57 days. (as 10 mg/kg) DO DO Opsonin DO DO DO Popular Pack size 20 ml vial Company Axon Animal Health ACME Enrofloxacin Generic dose: Dog- 2.5–20 mg/kg, IM/IV/PO. Cat- 2.5–5 mg/kg, PO/IM. Trade name Composition Trade dose Inj: Enrotril Each mL contain 0.1 ml/ 2-4 kg b.w. once, Max (L.A) Enrofloxacin I.PIM/SC, if need repeat 100 mg, after 72 h. Benzyl alcohol I.P -20 mg, Bytyl alcohol -50 mg, Arginin-20 mg Marbofloxacin Generic dose: Dog, cat- 2.75–5.5 mg/kg, q24, PO. Indication: belongs to 3rd generation Fluoroquinolone with broad spectrum bactericidal antimicrobial activity towards gram positive, gram negative bacteria and mycoplasma. Trade name Composition Trade dose Pack size Company Inj. Marbo Vet Each mL contains Treatment of Respiratory 10 mL, SK+F Marbofloxacin BP Infections30 mL, 100 mg. 1 mL/20 kg body weight 100 mL vial through IM/SC route for 3-5 days. (as 5 mg/kg body weight) Inj Marbores DO DO 20 ml ACI 10% Inj. Marboflox DO DO 10 ml Bridge Inj. Arbocin Vet DO DO DO Acme Tetracyclines Doxycycline, minocycline, and tetracycline are used in the treatment of respiratory and urinary tract infections (azotemic patient) in dogs and cats and as specific therapy for Borrelia (Lyme disease), Brucella, Leptospira, Rickettsiae, Chlamydia, Mycoplasma, Bartonella, Bordetella and 136 Haemobartonella spp. Pregnancy: Not safe. These drugs have been shown to cause congenital malformations or embryotoxicity. Doxycyline Generic dose: Dog: 5–10 mg/kg q12–24h IV, PO Cat: 5 mg/kg q12–24h IV, PO Adverse Effects: The most commonly reported side effects of oral doxycycline therapy in dogs and cats are vomiting, diarrhea and anorexia. Giving the drug with food may help alleviate these GI effects without significantly reducing drug absorption Trade name Composition Trade Dose Pack size Company Tab. Doxicap Doxycyline-100 mg 1 tab/20 kg BW. PO, q12-24 h 100 mg Renata (as 5 mg/kg BW) tablet Tab. Doxy A DO DO DO Acme Tab. Doxicap Doxycyline-50 mg 1 tab/10 kg BW. PO, q12-24 h 50 mg Renata (as 5 mg/kg BW) tablet Tab. Doxy A DO DO DO Acme Aminoglycosides Pregnancy: Not safe. Aminoglycosides can cross the placenta and while rare, may cause 8th cranial nerve toxicity or nephrotoxicity in fetuses Amikacin Generic dose: Dog: 15–30 mg/kg q24h IV, IM, SC. Cat: 10–20 mg/kg q24h IV, IM, SC. Indication: ✓ Amikacin’s spectrum of activity includes: coverage against many aerobic gram-negative and some aerobic gram-positive bacteria, including most species of E. coli, Klebsiella, Proteus, Pseudomonas, Salmonella, Enterobacter, Serratia, and Shigella, Mycoplasma, and Staphylococcus. Several strains of Pseudomonas aeruginosa, Proteus, and Serratia that are resistant to gentamicin will still be killed by amikacin. ✓ Antimicrobial activity of the aminoglycosides is enhanced in an alkaline environment. ✓ The aminoglycoside antibiotics are inactive against fungi, viruses and most anaerobic bacteria. Trade name Composition Trade Dose Pack size Company Inj. Akicin Amikacin: 50 mg/ ml Dog: 1 ml/ 2 kg BW, IM/IV. 2 mL Square (as 25 mg/kg) ampoule Cat: 1 ml/ 5 kg BW, IM/IV. (as 10 mg/kg) Inj. Kacin DO DO DO ACI Inj. Amikin DO DO DO Incepta Gentamicin Generic dose: Dogs: 10–14 mg/kg, IM, IV, or SC, q 24 h. Cats: 5–8 mg/kg, IV, IM, or SC, q 24 h. Indication: same as Amikacin. Adverse and common side effects: Nephrotoxicity, deafness, vestibular toxicity, respiratory paralysis and cardiovascular depression have been reported with the use of the drug, although otic 137 preparations of gentamicin sulfate does not adversely affect vestibular or cochlear function in healthy dogs. These drugs should be avoided in puppies and kittens because they are more likely to develop renal failure. Trade name Composition Trade Dose Vial size Company Inj. Genacyn-Vet Each ml contains Dog: 1 ml/ 10 kg BW, IM/IV. 10 ml, Sqaure 10 Gentamicin Sulphate (as 10 mg/kg) 100 ml BP 100 mg. Cat: 1 ml/ 20 kg BW, IM/IV. Vial (as 5 mg/kg) This dose preferably to be given twice for 1st day and afterwards once daily for 3-5 days. Inj. Acigent-10 DO DO DO ACI Inj. Genta-10 DO DO DO ACME Inj. Gentabac DO DO DO POPULAR vet Inj. Gentaren DO DO DO RENATA Inj. Intamycin DO DO DO Incepta vet Sulfonamides Sulfamethoxazole/Trimethoprim Generic dose: 15–30 mg/kg q12h–24h. Indication: Alone, sulfonamides are bacteriostatic agents and trimethoprim is bactericidal, but when used in combination, the potentiated sulfas are bactericidal. Trimethoprim + sulfamethoxazole is used for treatment of UTIs, skin and soft tissue infections, prostate infections, pneumonia, and CNS infections. The combination has not been successful for treating infections in abscesses or infections caused by anaerobic bacteria. The combination also is used occasionally for infections caused by protozoa (e.g., coccidial and Toxoplasma infections). Adverse effects: Renal crystalluria, Keratoconjunctivitis sicca (KCS), Hypoprothrombinemia, thrombocytopenia, and anemia occur rarely and are probably immune-mediated reactions. Trade name Composition Trade Dose Vial size Company Tab. Cotrim Sulfamethoxazole1 tab/20 kg, PO q12-24h 400 + 80 Square 400 mg (as 24 mg/kg) mg Trimethoprim- 80 mg tablet Tab. Politrim DO DO DO Acme Susp. Cotrim Each 5 ml contain 1 ml/2 kg BW, PO, q12-24h 60 ml Square Sulfamethoxazole(as 24 mg/kg) bottle 200 mg Trimethoprim- 40 mg Susp. Politrim DO DO DO Acme Macrolides Macrolides are active against most aerobic and anaerobic gram-positive bacteria, although there is considerable variation as to potency and activity. In general, macrolides are not active against gramnegative bacteria; however, some strains of Pasteurella, Haemophilus, and Neisseria spp may be susceptible. Exceptions include tilmicosin, gamithromycin, and tulathromycin, for which the spectra are characterized as broader and include Mannheimia haemolytica and Pasteurella multocida, as well as some gram-negative bacteria (ie, some strains of Pasteurella, Haemophilus, and Neisseria spp). Helicobacter also is generally included in the spectrum. Azithromycin, derived from erythromycin, includes Bordetella in its spectrum. 138 Bacteroides fragilis strains are moderately susceptible to macrolides. Macrolides are active against atypical mycobacteria, Mycobacterium, Mycoplasma, Chlamydia, and Rickettsia spp but not against protozoa or fungi. In vitro synergism occurs with cefamandole (against B fragilis), ampicillin (against Nocardia asteroides), and rifampin (against R equi). Pregnancy: safe. Azithromycin Generic dose: Dogs: 5–12 mg/kg, PO, q 24 h for 3–5d. Cats: 5–15 mg/kg, PO, q 24 h for 3–5d. Trade name Composition Trade dose Susp. Zibac Azithromycin 1 ml/ 4 kg BW, PO, q24h. 3-5 Dihydrate- 40 days. mg/ml (as 10 mg/kg) Susp. Zimax DO DO Susp. Azin Cap. Azin-250 mg DO Azithromycin Dihydrate- 250 mg Cap. Azicin Cap. Zimax DO DO DO 1 capsule for 25 kg, PO, q24h, 3-5 days. (as 10 mg/kg) DO DO Pack size 15 mL, 20 mL, 50 mL, Company Popular 15 mL, 30 mL, 50 mL bottle DO 250 mg capsule Square DO DO Opsonin Square Pack size 100 ml bottle Company Aristopharma DO 60 ml bottle Square Aristopharma DO Square Acme Acme Erythromycin (Prokinetic drugs also) Generic dose: Dog: 10–20 mg/kg q8h PO. Cat: 10–20 mg/kg PO q8h. Trade name Composition Trade dose Susp. Erythromycin: 1 ml for 2 kg BW, PO, q8h. 3-5 A-Mycin 25 mg/ml days. (as 12.5 mg/kg) Susp. Eromycin DO DO Pediatric drop. Erythromycin: 1 ml/4 kg or 5 drops/ kg bwt, A Mycin 40 mg/ ml PO, q8h, (as 10 mg/kg) Pediatric drop. DO DO Eromycin (Here, 1 ml = 20 drops.) Lincosamide Clindamycin Generic dose: 5–11 mg/kg, q12h, IM/IV/SC/PO. Indication: Most aerobic gram-positive cocci are susceptible to the lincosamides (Strep. faecalis is not) including Staphylococcus and Streptococci. Other organisms that are generally susceptible include: Corynebacterium diphtheriae, Nocardia asteroides, Erysepelothrix, Toxoplasma, and Mycoplasma spp. Anaerobic bacteria that are generally susceptible to the lincosamides include: Clostridium perfringens, C. tetani (not C. difficile), Bacteroides (including many strains of B. fragilis), Fusobacterium, Peptostreptococcus, Actinomyces, and Peptococcus. 139 Pregnancy: safe. Trade name Cap. Clindabac 150 Cap. Clindacin 150 Cap. Clindax 150 Composition Clindamycin: 150 mg Pack size 150 mg capsule Company Popular DO Trade dose 1 capsule for 15 kg, PO, q12h (as 10 mg/kg) DO DO Incepta DO DO DO Opsonin Lincomycin and Spectinomycin Description: The combination of Lincomycin and Spectinomycin acts as an additive and in some cases synergistic. Spectinomycin acts bacteriostatic or bactericidal, depending on the dose, against mainly Gram-negative bacteria like Campylobacter, E. coli, and Salmonella spp. Lincomycin acts bacteriostatic against mainly Gram-positive bacteria like Mycoplasma, Treponema, Staphylococcus and Streptococcus spp. Cross-resistance of Lincomycin with Macrolides can occur. Indications : Cats & Dogs: Treatment of respiratory, intestinal, urinary, skin infections (including wounds and abscess) and arthritis caused by organisms sensitive to the action of lincomycin and/or spectinomycin, including Staphylococcus spp., Streptococcus spp., Bacteroides spp., Clostridium spp., Fusobacterium spp., Actinomyces spp, Mycoplasma spp. Generic dose: Lincomycin: Dog: 22 mg/kg PO twice daily. Cat: 15 mg/kg PO q8h or 22 mg/kg PO q12h. Spectinomycin: 5–12 mg/kg IM q12h or 22 mg/kg PO q12h. Use in Pregnancy: safe. Trade name Composition Trade Dose Pack size Company Inj. Linospin Each ml injectable For IM or Subcutaneous 50 ml Bridge (Vet) solution contains Injection. Lincomycin Cats & Dogs: 1 ml/5 kg body hydrochloride USP 50 weight once daily for 3 days. mg and Spectinomycin Sulfate USP 100 mg. Nitroimidazoles Metronidazole Generic dose: 10–15 mg/kg PO q8–12h or 15–25 mg/kg PO q12–24h daily. For sepsis: 7.5-15 mg/kg IV q12h. Indication: It is a synthetic antibacterial, antiprotozoal agent that has been used in the treatment of giardiasis, trichomoniasis, amoebiasis, balantidiasis and trypanosomiasis. It has been used in the treatment of septicaemia, meningitis, peritonitis, biliary infections, colitis and gingivostomatitis, in which anaerobic bacteria are involved. Adverse and common side effects: Clinical signs generally begin 7-12 days after initiation of therapy. Nausea, anorexia, vomiting, lethargy, weakness and dose-dependent neurologic signs (Ataxia, nystagmus, seizure, head tilt, bradycardia, rigidity and stiffness) have been reported. Neutropenia and hematuria also have been seen in some dogs. The tablets have a bitter taste and should not be crushed before use. The drug also may be mutagenic and should not be given to pregnant animal. Trade name Composition Trade Dose Pack Company size 140 Inj. Metro IV (infusion) Inj. Amodis IV (infusion) Inj. Filmet IV (infusion) Inj. Flagyl IV Susp. Amodis Metronidazole: 5 mg/ml 100 ml DO 2 ml/ kg BW, IV, q12-24h. (as 10 mg/kg) DO DO OPSO saline Square DO DO DO Beximco DO Metronidazole: 40 mg/ml DO 1 ml/4 kg BW, PO, q12h. (as 10 mg/kg) DO DO 1 tab/ 20 kg BW PO q1224h. (as 20 mg/kg) DO DO DO DO 60 ml Synovia Square Susp. Filmet Susp. Flagyl Tab. Amodis DO DO Metronidazole: 400 mg DO DO Beximco Synovia Square Tab. Filmet Tab. Flagyl Tab. Metryl DO DO DO Beximco Synovia Opsonin Antibiotic Eye drops See farm animal medicine, page- 42 Anti Glaucoma Eye drops See farm animal medicine, page- 43 Antibiotic Ear drops See farm animal medicine, page- 43 Antibiotic Topical preparations See farm animal medicine, page- 43 Antifungal antibiotic Griseofulvin (microsize/ultramicrosize) Generic dose: Dogs: Microsize: 25 mg/kg q12h PO for 42–56 days or 50 mg/kg PO once daily with fatty meal. Ultramicrosize: 5–10 mg/kg PO once daily for 42 days. Cats: Microsize: 50–120 mg/kg PO; divided daily. Give with a fatty meal. Ultramicrosize: 10–15 mg/kg PO twice daily. Give for 4–6 weeks or longer, until culture is negative. Indication: Fungistatic antibiotic used primarily for ringworm & other dermatophytic infections. Griseofulvin has activity against species of Trichophyton, Microsporum and Epidermophyton. Only new hair and nail growth is resistant to infection. It has no antibacterial activity and is not clinically useful against other pathogenic fungi, including Malassezia yeasts. Contraindications: Pregnancy, known hypersensitivity, or hepatocellular failure Caution: Kittens may be overly sensitive to the drug; cats with FIV Adverse Effects: Anorexia, vomiting, diarrhea, anemia, neutropenia, leukopenia, thrombocytopenia, depression, ataxia, hepatotoxicity, or dermatitis/photosensitivity Trade name Composition Trade dose Pack size Company Tab. Griseofulvin 1 tab/ 10 kg BW PO q24h. 500 mg APC Griseofulvin (Microsize): 500 mg (as 50 mg/kg) tablets 141 Tab. Griseofulvin FP Bol. Dermaphyl Vet DO DO DO Bristol Griseofulvin: 2.5 gm 10-30 mg/kg BW/day 2.5 gm bolus Navana Nystatin Generic dose: Dog: 50,000–150,000 IU q8h PO Cat: 100,000 IU q6h PO Uses/Indications: Orally administered nystatin is used primarily for the treatment of oral or gastrointestinal tract Candida infections in dogs, cats, and birds; it has been used less commonly in other species for the same indications. Use in Pregnancy: pregnancy safety not established. Trade name Composition Dose Pack size Company Susp. Nystat Nystatin: 100,000 Unit/mL 1 ml PO, q8h. 30 mL ACME bottle Susp. Candex DO DO DO SQUARE Susp. Canstat DO DO DO JAYSON Susp. Fungistin DO DO 12 ml BEXIMCO Azoles The antifungal azoles also have some antibacterial action but are rarely administered for this purpose. Miconazole has a wide antifungal spectrum against most fungi and yeasts of veterinary interest. Sensitive organisms include B dermatitidis, P brasiliensis, H capsulatum, Candida spp, C immitis, C neoformans, and A fumigatus. Some Aspergillus and Madurella spp are only marginally sensitive. Ketoconazole has an antifungal spectrum similar to that of miconazole, but it is more effective against C immitis and some other yeasts and fungi. Itraconazole and fluconazole are the most active of the antifungal imidazoles. Their spectrum includes dimorphic fungal organisms and dermatophytes. They are also effective against some cases of aspergillosis (60%–70%) and cutaneous sporotrichosis. However, fluconazole is less efficacious against Aspergillus species. Clotrimazole and econazole are administered for superficial mycoses (dermatophytosis and candidiasis); econazole also has been used for oculomycosis. Thiabendazole is effective against Aspergillus and Penicillium spp; however, its use has largely been replaced by the more effective imidazoles. Voriconazole and posaconazole are considered newer-generation azoles that posses a wide range of activity and are more effective against Candida and Aspergillus compared to classic triazoles. Voriconazole is approved for human use in treatment of Aspergillus but is effective against many other fungal organisms. Posaconazole may be more effective than itraconazole or fluconazole but may be associated with more adverse effects. Ketoconazole Generic dose: Dog: 10–15 mg/kg q12h PO Cat: 5–10 mg/kg q8–12h PO 142 Uses/Indications : Original imidazole oral antifungal used for systemic mycoses, including aspergillosis, cryptococcal meningitis, blastomycosis, & histoplasmosis; also used to reduce dose/costs of cyclosporine therapy and as an alternative treatment of hyperadrenocorticism in dogs. Contraindications: Known hypersensitivity; some believe ketoconazole is contraindicated in cats Caution: Hepatic disease or thrombocytopenia. Adverse Effects: GI (anorexia, vomiting, &/or diarrhea) most common & more prevalent in cats; hepatic toxicity, thrombocytopenia, reversible lightening of haircoat, transient dose-related suppressant effect on gonadal & adrenal steroid synthesis. May cause infertility in male dogs by decreasing testosterone synthesis. Potentially teratogenic & embryotoxic. Trade name Composition Trade Dose Pack size Company Tab. Ketocon Ketoconazole-200 1 tab/ 20 kg BW PO q12-24h. 200 mg Opsonin 200 mg mg (as 10 mg/kg) tablet Tab. Ketoral DO DO DO Square 200 mg Shampoo. Ketoconazole-2% Dilute 1 : 4 before application, 60 ml, Unimed Nizoder 2% and shampoo for at least 3-5 100 ml minutes, weekly bottle Shampoo. DO DO DO Incepta Dancel 2% Cream. Ketoconazole-20 apply locally on the affected 15 gm Opsonin Ketocon 2% mg/gm area 2-3 times per day. tube Cream. DO DO DO Unimed Nizoder 2% Fluconazole Generic dose: Dog: 2.5–15 mg/kg q12–24h PO Cat: 50–100 mg/cat q12–24h PO Uses/Indications: Fluconazole may have use in veterinary medicine in the treatment of systemic mycoses, including cryptococcal meningitis, blastomycosis, and histoplasmosis. It may also be useful for superficial candidiasis or dermatophytosis. Adverse Effects: Occasional GI effects (inappetence) in cats or dogs; in humans: headache &, rarely, increased liver enzymes & hepatic toxicity. Use in Pregnancy: not safe. Trade name Composition Trade Dose Pack size Company Susp: Flucon Fluconazole: 10 1 ml / kg PO q 12h. 35 ml Opsonin mg/ml (as 10 mg/kg) bottle Susp. DO DO DO ACI Canazole Susp. F-Zol DO DO DO Popular Cap. F-Zol Fluconazole: 200 mg 1 cap/ 20 kg BW PO q12200 mg Popular 24h. capsule (as 10 mg/kg) Cap. Diflu 200 DO DO DO Aristopharma Cap: Flucon DO DO DO Opsonin Itraconazole Generic dose: Dog: 5–10 mg/kg q12–24h PO Cat: 5–10 mg/kg q12 or 20 mg/kg q24h PO 143 Uses/Indications: Itraconazole may have use in veterinary medicine in the treatment of systemic mycoses, including aspergillosis, cryptococcal meningitis, blastomycosis, and histoplasmosis. Itraconazole is probably more effective than ketoconazole, but is significantly more expensive. It may also be useful for superficial candidiasis or dermatophytosis. Itraconazole does not have appreciable effects (unlike ketoconazole) on hormone synthesis and may have fewer side effects than ketoconazole in small animals. It is considered by many to be the drug of choice for treating blastomycosis, unless moderate or severe hypoxemia is present (than amphotericin B). Adverse Effects: Dogs: Anorexia is the most common, but hepatic toxicity most significant adverse effect. At the higher dosage rate, some develop ulcerative skin lesions/vasculitis & limb edema. Rare, serious erythema multiforme or toxic epidermal necrolysis. Cats: Dose related; GI effects (anorexia, weight loss, vomiting), hepatotoxicity (increased ALT, jaundice), & depression. Use in Pregnancy: In laboratory animals, itraconazole has caused dose-related maternotoxicity, fetotoxicity and teratogenicity at high dosages (5–20 times). As safety has not been established, use only when the benefits outweigh the potential risks. Trade name Composition Trade Dose Pack size Company Cap. Itra 100 Itraconazole-100 1 cap/ 10 kg BW PO q12-24h. 100 mg Square mg mg (as 10 mg/kg) capsule Cap. I-Zol 100 DO DO DO Popular mg Cap. Itrazen DO DO DO Beacon 100 mg Terbinafine Generic dose: 30–40 mg/kg q24h PO. Or 5–10 mg/kg/day, PO, when combined with itraconazole. Uses/Indications: Terbinafine may be useful for treating dermatophytic and other fungal infections in dogs and cats. Trade name Composition Dose Pack size Company Tab. Terbin Terbinafine Hydrochloride- 250 mg 250 mg tablet Opsonin DO 1 tab/8.3 kg, PO q 24h, daily or week on/week off until cured. (as 30 mg/kg) DO Tab. Mycofin DO SK+F Tab. Telfin DO DO DO Beacon Cream. Terbimax 1% Terbinafine Hydrochloride- 1% 10 gm tube Renata Cream. Terbin 1% DO Apply locally on the affected area 2-3 times per day. DO DO Opsonin Cream. Terbikill DO DO 15 gm tube Acme Topical anti-fungal preparation Whitfield’s ointment Indication: Hyperkeratosis, parakeratosis, fungal dermatitis. Trade name Composition Dose Pack size Company 144 Oint. Dermin Apply locally on the affected area 2-3 times/day. Do 25 gm tube JAYSON Oint. Whitfield Benzoic acid- 6%, salicylic acid- 3%, Vaseline- 91% Do Do Asiatic Oint. Bensal Do Do Do G.A. Antiviral agents Zidovudine Generic dose: 5–10 mg/kg q12h PO or SC. Uses/Indications: In veterinary medicine, zidovudine may be useful for treating feline immunodeficiency virus (FIV) or feline leukemia virus (FeLV). While zidovudine can reduce the viral load in infected cats and improve clinical signs, it may not alter the natural course of the disease to a great extent. Use in Pregnancy: not safe. Trade name Composition Dose Pack size Company Syp. Zidovudine Zidovudine: 10 mg/mL 1 ml / kg PO q 12h. (as 10 mg/kg) EDCL Acyclovir Generic dose: Cat: 10–25 mg/kg q12h SC, or 10–25 mg/kg PO twice daily. Never begin therapy until diagnostic evaluation is completed. May be toxic in cats; monitor CBC every 2–3 weeks. Uses/Indications: Acyclovir may be useful in treating herpes infections in a variety of avian species and in cats with corneal or conjunctival herpes infections. Its use in veterinary medicine is not well established, however, and it should be used with caution. Acyclovir has relatively mild activity against Feline Herpesvirus-1 when compared to some of the newer antiviral agents (e.g. ganciclovir, cidofovir, or penciclovir). Use in Pregnancy: not safe. Trade name Composition Dose Pack size Company Susp. Virux Acyclovir-40 mg/ml 1 ml / 4 kg PO q 12h. 70 ml bottle Square (as 10 mg/kg) Susp. Acerux DO DO DO Opsonin Tab. Virux 200 mg Acyclovir-200 mg Tab. Xovir 200 mg DO 1 tab/ 20 kg BW PO q12h. (as 10 mg/kg) DO 200 mg tablet Square DO Beacon (Topical cream, Eye ointment and IV preparation are available in Human. Follow DIMS app for more trade.) Remdesivir Generic dose: Cat-10 mg/kg body weight once in a day subcutaneously up to period of 12 weeks or 84 days. Uses/Indications: To treat Feline Infectious Peritonitis Virus (FIPV) Mode of action: Remdesivir or GS-441524 works by blocking FIP viral RNA replications. Active form of the drug works as a nucleoside analogue, meaning it mimic the nucleoside building blocks—A, U, C, or G—that make up the virus’s genetic code. Specifically, it mimics “A”. When the virus is tricked into incorporating a GS-441524 molecule (active form of remdesivir) instead of “A”, the replication process breaks down. It leads to premature termination of viral RNA synthesis and inhibition of viral replication. Prognosis: Cats treated with remdesivir has shown a good prognosis and more than 80% 145 recovery rate. In severe cases intravenous administration of loading dose for first 2-3 days have shown promising response and recovery. In severe cases not responding to the therapy, euthanasia may be the only option to prevent further suffering. Trade Composition Dose Pack size Company name Inj. Remdesivir- 5 1 ml/ 2 kg BW, SC in a day 100 mg vial with Incepta Ninavir mg/ml for 12 weeks or 84 days. 2 ampoules of 10 ml Water for Injection (WFI) Inj. DO DO DO Popular Ramdivir Inj. DO DO DO SK+F Remivir Antiparasitic drugs Pyrantel pamoate Mode of action: Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which paralyzes the organism. The drug possesses nicotine-like properties and acts similarly to acetylcholine. It also inhibits cholinesterase. Generic dose: Dog<2.5 kg- 10 mg/kg PO. >2.5 kg- 5 mg/kg PO, repeat in 7–10 days. Treat puppies at 2, 4, 6, 8, and 10 weeks of age. Treat lactating bitches 2–3 weeks after whelping. Cat- 5-10 mg/kg PO. repeat in 2-3 weeks. Treat kittens at 3, 5, 7, and 9 week of age at 5–10 mg/kg PO. Uses/Indications: Pyrantel has been used for the removal of the following parasites in dogs: ascarids (Toxocara canis, T. leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala), and stomach worm (Physaloptera). A. caninum resistance has been reported. Although not FDAapproved for use in cats, it is useful for similar parasites and is considered safe to use. Contraindication: Pregnancy Trade name Composition Trade dose Vial size Company Susp. Delentin Pyrantel pamoate- 50 1 ml/10 kg BW PO. Or 2 10 ml Renata mg/ml drops/ kg BW PO. (as 5 mg/kg) Susp. Melphin DO DO 10 ml Beximco Susp. Wormex DO DO 10 ml Hallmark (Here 1 ml = 20 drops) Fenbendazole Generic dose: 50 mg/kg/d for 3d, PO. Uses/Indications: Fenbendazole is indicated for the removal of the following parasites in dogs: ascarids (Toxocara canis, T. leonina), Hookworms (Ancylostoma caninum, Uncinaria stenocephala), whipworms (Trichuris vulpis), and tapeworms (Taenia pisiformis). It is not effective against Dipylidium caninum. Fenbendazole has also been used clinically to treat Capillaria aerophilia, Filaroides hirthi, and Paragonimus kellicotti infections in dogs. Fenbendazole can be used effectively against Giardia. Use in Pregnancy: is generally considered safe to use in pregnancy for all species. Trade name Composition Dose Pack size Company 146 Bolus. Peraclear (vet) Fenbendazole-250 mg Bol. Fenazol vet Do Liq. Fenazol vet Each ml contains Fenbendazole BP-200 mg. 1 bolus/ 5 kg BW PO q24h. (as 50 mg/kg) Do 250 mg bolus Techno Do Acme Dogs: 1 ml/2 kg body weight as a single dose or 1 ml/ 10 kg body weight daily for 5 days. 100 ml, 500 ml ACME Mebendazole Uses/Indications: broad-spectrum dewormer. Active against nematode, trematode & Cestode. Trade name Composition Dose Pack size Company Bol. Nemadex (vet) Each bolus contains Mebendazole 750 mg. Tab. Solas Mebendazole-100 mg. Tab. Panamox Tab. Mebendol DO DO Orally Dog: 1 bolus/ 15-30 kg BW (as 25-50 mg/kg BW) 1 tab/4 kg BW,PO. (as 25 mg/kg) DO DO 750 mg bolus Super power 100 mg tablet DO DO Opsonin Jayson Doctors Praziquantel Generic dose: 2.5-7.5 mg/kg, PO. Uses/Indications: Praziquantel is indicated for (FDA-approved labeling) for the treatment of Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosis in dogs, and Dipylidium caninum and Taenia taeniaeformis in cats. Fasting is not required nor recommended before dosing. A single dose is usually effective, but measures should be taken to prevent reinfection, particularly against D.caninum. Praziquantel can also be used for treating Alaria spp. in dogs and cats and Spirometra mansonoides infections in cats. Contraindications: Puppies less than 4 weeks old or kittens less than 6 weeks old; hypersensitivity to the drug. Use in Pregnancy: safe. Pack Trade name Composition Trade dose Company size 1 Tablet for 10 kg body weight. 1 tablets contains, Praziquantel-50 mg. Pyrantel embonate144 mg. Febantel- 150 mg. -The tablets can be given directly to the dogs and cats Tab. 1 or disguised in food. No Helminticide-L tablet starvation is needed before or after treatment. -For rountine control dogs and cats should be treated every 3 months. Helminticide-L treatment for common worms in Dogs & Cats. Broad-spectrum dewormer used in dogs puppies and cat kittens to treat tapeworms, hookworms and roundworms. Use in Pregnancy: Helminticide L isn’t safe. Each Kiwof chewable ½ tablet – 2 kg bodyweight Tab. Kiwof 1 tablet contains 1 tablet – 2.1 to 4 kg SAVAvet (cat) tablet Praziquantel- 20 mg bodyweight 147 Pyrantel Pamoate1 ½ tablets – 4 to 6 kg 230 mg bodyweight Excipients-QS Kiwof cat dewormer is indicated for the treatment and control of: Hookworms (Ancylostoma tubaeforme, Ancyclostoma brazilense, Uncinaria stenocephala) Roundworms (Toxocara cati, Toxocara leonina) Tapeworms (Diphylidium caninum, Taenia taeniaformis) in cats. Ivermectin Generic dose: 0.2–0.4 mg/kg SC, PO. Uses/Indications: In dogs and cats, ivermectin is FDA-approved only for use as a preventative for heartworm. It has also been used as a microfilaricide, slow-kill adulticide, ectoparasiticide, and endoparasiticide. Use in Pregnancy: Ivermectin is considered safe to use during pregnancy. Ivermectin is 10 times safe in dogs. Trade name Composition Trade dose Pack size Company Ivermectin: 10 1 ml / 50 kg BW, SC. 5 ml, Inj. Vermic Techno mg/ml (as 0.2 mg/kg) 10 mL Inj. Invet DO DO Do Popular lnj. Acimec 1% DO DO Do ACI Inj. Parasitin vet DO DO Do Square Inj. A-mectin DO DO 5 ml Acme 1 tab / 20 kg BW, oral. 6 mg Tab. Ivactin 6 Ivermectin- 6 mg Aristopharma (as 0.3 mg/kg) tablet DO DO DO Tab. Ivera 6 Beximco DO DO DO Tab. A-mectin 6 Acme Ectoparasiticides Selamectin (Topical antiparasitic) Generic dose: The recommended topical dose is 6 mg/kg. Uses/Indications: Topical selamectin is indicated for flea infestations (Ctenocephalides felis), prevention of heartworm disease (Dirofilaria immitis), and for ear mites (Otodectes cynotis) in both dogs and cats. Additionally in dogs, it is indicated for sarcoptic mange (Sarcoptes scabeii), and tick infestations (Dermacentor variabilis). In cats it is indicated for hookworms (Ancylostoma tubaeforme) and roundworms (Toxocara cati). Reproductive/Nursing Safety: Selamectin appears to be safe to use in pregnant or lactating dogs or cats. Trade name Composition Trade dose Pack size Company -1 ml*3 doses pipette for Each pack 1 ml & 2 ml pack dogs of weight 20.1-40lbs contains contains 120 mg & (9 kg-18 kg) and age 3 doses Revolution Spot 240 mg selamectin minimum 6 weeks. (1 ml Zoetis on (dog) respectively in each -2 ml*3 doses pipette is dose/ pipette. for dogs of weight 40.12 ml 85lbs (18 kg-39 kg) . dose) Revolution spot on by Zoetis is a selamectin topical ectoparasite killer for dogs. It acts(kills) on ticks, mites, fleas, mange – larvae as well as adult parasites. Effect lasts for 1 month for 1 pipette. Safe for puppies as young as 6 weeks as well as pregnant dogs. Also suitable for ivermectin sensitive dogs. 148 Each pack Contains 0.75 ml or 0.75 ml*3 doses pipette contains Revolution Spot 45 mg selamectin in for weight 2 kg-7 kg 3 doses Zoetis on (Cat) each pipette. (5.1lbs-15lbs). (0.75 ml/dose) Revolution plus spot on for cats and kittens contains selamectin that helps kill fleas, ticks, mites, roundworms, hookworms, heartworms, ear mites and tapeworms. It has very broad scope of action while being single dose therapy. It helps prevent heartworm disease caused by Dirofilaria immitis and the treatment and control of ear mite infestations. Kills adult fleas as well as flea eggs or larvae. Suitable for kittens and cats of age above 8 weeks. Fipronil Pharmacological properties: Biotransformation In all species, fipronil is mainly metabolized to its sulphone derivative, which also possesses insecticidal and acaricidal properties. Fipronil is an insecticide and acaricide from the phenylpyrazole family inhibits the GABA complex, binding to the ligand-gated chloride channel blockage of pre and post synaptic transfer of chloride ions across the membrane uncontrolled, activity of the central nervous system, death of insects and acarids. Generic dose: 6.5–13 mg/kg q1 month, Topical. Indication: Treatment and prevention of infestation by fleas and ticks in dogs and cats. Fipronil exhibits insecticidal and acaricidal activity against fleas (Ctenocephalides spp), ticks (Rhipicephalus spp., Ixodes spp.) and lice (Trichodectes spp. and Felicola spp.), Neotrombicula autumnalis, Sarcoptes spp. and Cheyletiella spp. in the dog and cat. Note: Avoid spraying in eyes, nose or mouth. Shake well before use, spray in an upright position 1520 cm. Do not bathe the animal 24 hours after spraying. Trade name Composition Trade dose Pack size Company Dogs and cats – Less than 5 kg: Each 100 ml 100 ml 6 spraying / kg, Up to 12 / Frontline contains: kg in case of long hair. 100 ml Square Spray Fipronil: 0.25 gm Dogs and cats + More than 5kg: 250 ml 250 ml or 500 ml 2 spraying / kg, Up to 4 / kg in case of long hair. 1. Small Part the dog's hair between the dogs/ shoulder blades. Place the puppies applicator tip just above the skin (3X0.67 Fipronil 9.8%, (S)and squeeze. Apply entire contents ml): 8 methoprene 8.8%, of the applicator in a single spot weeks or Frontline Inert ingredients directly onto the dog's skin. Do not older and Square Plus 81.4% Clearapply on top of the hair coat. Avoid upto 10 Kgs amber Spot-on contact with treated area until dry. 2. Large solution Do not allow your dog to ingest the dogs product. Do not use more than one (3X2.68 application per dog per month. ml): only 20-40 Kgs Amitraz Trade name Soln. Ridd Composition Amitraz B.P. Vet. : 12.5 % w/v Emulsifiable carrier : Q.S. Trade dose One application per week is advised. Dilution is to be done as follows (per liter of water) Pack size Company 60 ml 15 ml (Imported products) 149 Dogs and Cats: Ticks and Fleas – 2 ml Mange – 3-4 ml Large Animals Earsore / Humpsore / Tailsore or dermatitis – 2 ml Mange: 3-4 ml Sarcoptic mange: 2-3 applications Demodectic mange: 5-8 applications DESCRIPTION: Ectoparasites like ticks, fleas and mange mites can do more harm than triggering allergic reactions in animals. They are often the causes of many skin diseases. The quicker these parasites leave, the better it is for the animals. The penetrative power of the solution is such that it leaves no parasites alive on your pet’s skin. It also gives relief to the persistent itching and scratching in dogs. Ridd works by cutting of the oxygen supply of the parasites completely. The low toxicity of the solution makes it absolutely safe for the animals. It also tackles mange mites in all stages of their development. METHOD OF APPLICATION ✓ Trim the pet’s hair, especially around the affected areas ✓ Give a complete bath to the pet and pat dry with a towel. ✓ Make a dip concentrate as per the dosage. ✓ Apply the solution uniformly all over the body and on the affected areas liberally with a thorough scrubbing. ✓ Allow it to dry. ✓ Do not give a bath for a week after application. Others Trade name Composition Trade dose Pack size Company Direction for use: Wet coat with luke warm water. Apply and lather PROTEX-G over the entire body. ContainsSoap: Allow 10 minutes of contact time. 75 gm Permethrin…5% Geevet Protex-G Rinse thoroughly with water. soap w/w Protect and provides good residual efficacy. For topical use only: Wet the coat completely, gently Miconazole apply the shampoo all over the Shampoo: Nitrate & body and let it stay for 20 minutes. 200 ml Pet Care PetHex Chlorhexidine Avoid eyes and ears. Rinse Gluconate thoroughly and give a towel dry. PetHex skin care Shampoo is specially formulated for dog skin to ensure several reliefs such as dryness, itchiness, allergies, fungal or bacterial infections & so on. The shampoo is most recommended by the veterinarians. -The shampoo can be used normally with the regular bathing of the dog. It gently cleans the skin and ensures softness with moisture. -The shampoo is formulated with the natural ingredient which confirms the risk-free uses. Wet the pet’s body thoroughly Liq. Himalaya with water. Apply the required Himalaya Neem, Eucalyptus 200 ml Wellness quantity of shampoo and rub Erina-EP Company, thoroughly into the hair root to 150 obtain a lather. Leave the lather on the body for 10-15 minutes and wash with water. Pat dry with towel and brush the coat when dry, or use as directed by the veterinarian. Erina EP controls ectoparasites like ticks, fleas, and lice in pets. Its antimicrobial and antifungal actions, prevent skin infections and improves the overall condition of the skin. Wet coat thoroughly with warm water. Apply required amount of Med-Vet Chlorhexidine shampoo to create rich lather over Biolinks Liq. Micodin Gluconate & 200 ml the entire body. Allow to remain Private Miconazole on hair for 5 – 10 minutes then Limited. rinse thoroughly with clean water. Micodin is Medicated Anti Bacterial & Anti Fungal Shampoo For Dogs & Cats Specially formulated with a synergistic combination of Chlorhexidine Gluconate & Miconazole. The component Chlorhexidine Gluconate provides a broad spectrum bactericidal activity and by binding to the proteins of the skin for increasing the residual activity. Miconazole is highly effective against gram-positive bacteria, fungi, yeast which includes the Malassezia pachydermatis. The Micodin is designed especially for effective cleansing as well as enhanced antimicrobial activity Antiprotozoal drugs Imidocarb dipropionate Indication: Babesiosis (mainly), Anaplasmosis, Ehrlichiosis, Hepatozoonosis, cytauxzoonosis (C. felis), feline hemoplasmosis (Haemobartonellosis; Mycoplasma haemofelis, Mycoplasma Haemominutum). Generic dose: Dog: 5–6.6 mg/kg IM or SC; repeat in 14 days Cat: 3–5 mg/kg IM; repeat 7 days after initial dose Contraindications: Animals hypersensitive to Imidocarb Dipropionate & having impaired lung, liver & kidney function. Use in Pregnancy: The safety and effectiveness of Imidocarb have not been determined in breeding, lactating or pregnant animals. Caution: Before administration of Imidocarb, Atropine sulfate should be administered at 30 miniutes before. Trade name Composition Trade dose Pack size Company Inj. Ectorid Each mL contains 1 ml/ 20 kg BW deep IM/SC 10 ml RENATA Imidocarb Dipropionate- 133.26 (as 4.5 mg/kg BW) mg (Equivalent to 93.5 mg Imidocarb base) Inj. Babenil Do Do 2 ml vial TECHNO 10 ml vial Inj. Babecure Each ml injectable 1 ml/ 20 kg BW deep IM/SC 2 ml ACME solution contains (as 6 mg/kg BW) ampoule Imidocarb Dipropionate INN 120 mg 151 Diminazine aceturate Indication: Babesiosis, Trypanosomiasis, Cytauxzoonosis in cats. Generic dose: Dog: 3.5–7 mg/kg IM, repeat in 7-14 days. Cat: 3–5 mg/kg IM one time. or 2 mg/kg IM repeat in one week. Use in Pregnancy and Lactation: No adverse effect has been reported at recommended dose. Caution: Before administration of Diminazine, Atropine sulfate should be administered at 30 miniutes before. Trade name Composition Trade dose Pack Company size Inj. Berenil Each ml contains: Deep intramuscular or 20 ml, INTERVET Vet 7% RTU Diminazene aceturate- 70 subcutaneous at the side 30 ml, mg of the neck. 90 ml Phenazone BP: 375.0 mg Water for injection q.s. to 1 1 ml/ 20 kg, repeat often ml 24hrs Inj. BabcopDo Do 20 ml SQUARE Vet vial Inj. Diminal Each 1 g contain Do 2.36 g, Eagle Vet. Diminazene diaceturateOr Tech 445 mg 23.6 g (Imported Phenazone- 555 mg by ACI) DIMINAL To prepare the injection solution ready for use, the contents of a bag of 23.6g DIMINAL are dissolved in 150 ml water for injection and the contents of a bag of 2.36g DIMINAL are dissolve in 15 ml water for injection. Autacoids Antihistaminic Use in Pregnancy: Safety during pregnancy has not been established. Pheniramine maleate (moderately-sedative, H-1 blocker) Generic dose: 1-2 mg/Kg BW, PO/IV/IM. Indication: Itching at different areas of body, drug allergy, hay fever, urticaria, inflammation, constipation, rhinitis, pulmonary oedema, local anaesthesia, bronchospasm, puerperal toxemia, inflammation of stomach and uterus. Trade name Composition Trade dose Pack size Company Inj. Antihista vet Each ml contains 1 ml /10 kg BW, q24h, IM or 10 ml SQUARE Pheniramine IV. Maleate BP 22.75 (as 2 mg/kg) mg. Inj. Histavet Do Do Do ACI Inj. Asta-vet Do Do Do ACME Inj. Niravet Do Do Do OPSONIN Inj. Alerin Do Do Do SK+F Syp. Alervil Pheniramine 1 ml/ 3 kg BW PO. 75 ml Incepta Maleate-3 mg/ml (as 1 mg/kg) bottle 152 Syp. Avil Syp. Aerovil Do Do Do Do Do 100 ml Synovia Beximco Chlorpheniramine maleate (1st generation, mild-sedative, H-1 blocker) Generic dose: Dog: 0.2–0.8 mg/kg PO 2-3 times a day ,PO. Or 4–12 mg, PO (total dose) two to three times daily. Cat: 2–4 mg per cat q12–24h, PO. Uses/Indications: Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects. Chlorpheniramine is one the more commonly used antihistamines in the cat for the treatment of pruritus. It may also be of benefit as a mild sedative in small animals due to its CNS depressant effects. Trade name Composition Trade dose Pack size Company Inj. Histacin vet Chlorpheniramine 1 ml/20 kg BW IM/IV, 10 ml Jayson maleate: 10 mg/ml q24h. (as 0.5 mg/kg) Inj. Renacin vet Do Do 10 ml Renata Inj. Fenarvet Do Do 10 ml Techno Syp. Histacin Chlorpheniramine 1 ml/ 4 kg BW PO. 60 ml bottle Jayson maleate: 2 mg/ 5 ml (as 0.5 mg/kg) Syp. Histal Do Do Do Opsonin Syp. Histanol Do Do 100 ml Chemist bottle Diphenhydramine st (1 generation, highly-sedative, H-1 blocker) Generic dose: 2–5 mg/kg q6–8h IV, IM, SC, PO. Uses/Indications: In veterinary medicine, diphenhydramine is used principally for its antihistaminic effects, but also for other pharmacologic actions. Its sedative effects can be of benefit in treating the agitation (pruritus, etc.) associated with allergic responses. It has also been used for treatment and prevention of motion sickness and as an antiemetic in small animals. Trade name Composition Trade dose Pack size Company Inj Phenadryl Diphenhydramine 1 ml/ 10 kg BW IM/IV 10 ml, ACME vet Hydrochloride - 20 mg/ml (as 2 mg/kg) 30 ml vial Syrup: Diphenhydramine 1 ml/ kg BW PO. 100 ml Acme Phenadryl Hydrochloride- 2 mg /ml (as 2 mg/kg) bottle Syp. Adryl Do Do Do Square Syp. Dorenta Do Do Do SK+F Promethazine st (1 generation, highly-sedative, H-1 blocker) Mode of action: Promethazine binds with H1 receptor and Stops histamine release. Indication: It is effective in anaphylactic reactions and in many allergic disorders including- Allergic dermatoses, Eczema, Urticaria, Allergic rhinitis, Anaphylactic shock, Insect bite. Generic dose: Dog, Cat: As antihistaminic: 0.2-0.4 mg/kg BW, IM/IV/PO q6-8h. As antiemetic: 2 mg/kg, PO/IM q24h. Use in Pregnancy: Not safe. Adverse effects: CNS depression: Lethargy, somnolence, ataxia 153 Contraindication: Hypersensitive patient, heart disease, high blood pressure, narrow angle glaucoma. Trade name Composition Trade dose Pack size Company Inj. Dellergen Each ml contains: Dog/cat: 0.5-2.5 ml/10 kg BW 10 ml RENATA Promethazine IM hydrochloride USP 50 mg. Inj. Phenerax DO DO DO JAYSON vet Inj. Flugan (vet) DO DO DO TECHNO Inj. Promodin DO DO DO CHEMIST vet Cetirizine nd (2 generation, Non-sedative, H-1 blocker) Generic dose: Dog: 5–10 mg PO Cat: 1 mg/kg PO Uses/Indications: Cetirizine is a H1 receptor blocking antihistamine agent that may be useful for the adjunctive treatment of histamine-mediated pruritic conditions in dogs or cats. Trade name Composition Trade dose Pack size Company Syp. Alatrol Cetirizine 1 ml/ kg BW PO q12-24h. 60 ml Square hydrochloride-1 (as 1 mg/kg) bottle mg/ml Syp. Atrizin Do Do Do Beximco Syp. Acitrin Do Do Do ACI Paediatric Cetirizine (1 ml=20 drops) / 2.5 kg BW 15 ml ACI drop. Acitrin hydrochloride- 2.5 PO q12-24h. bottle mg/ml (as 1 mg/kg) Paediatric Do Do Do Beximco drop. Atrizin Paediatric Do Do Do Square drop. Alatrol Loratadine nd Trade name Tab. Alaron (2 generation non-sedative, H-1 blocker) Dog: Small size- 5 mg PO q12h Medium size- 10 mg PO q24h Large size- 10 mg PO q12h Composition Trade dose Loratadine- 10 mg See the generic Tab. Lora Tab. Loratin Susp. ALaron Susp. Lora Susp. Orin Do Do Loratadine- 1 mg/ml Do Do Generic dose: Do Do Do Do Do Pack size 10 mg tablet Do Do 60 ml Do Do Company ACI Opsonin Square ACI Opsonin Acme Fexofenadine nd (2 generation non-sedative, H-1 blocker) Generic dose: Dog- 2–5 mg/kg PO q24h 154 Trade name Tab. Fexo Composition Fexofenadine- 60 mg Tab. Rich 60 Susp. Fexo Do Fexofenadine- 6 mg/ml Do Susp. Ritch Trade dose 1 tab/12 kg PO, q24h (as 5 mg/kg BW) Do 1 ml/2 kg, BW,PO q24h (as 3 mg/kg BW) Do Pack size 60 mg tablet Do 50 ml Company Square Do ACI ACI Square Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Indications: Treatment of pain, pyrexia and inflammation. ✓ Musculoskeletal disorders: Arthritis, laminitis, tendonitis, myositis. ✓ Pain: headache, earache, body ache, neuralgia, pain due to intestinal inflammation rheumatoid fever, post vaccination pain, post-delivery pain, post-operative pain. ✓ Tissue swollen resulting from trauma, injury, burn or any other infectious diseases. Precautions: Do not administer concurrently with steroidal anti-inflammatory drugs (SAID) & other non-steroidal anti-inflammatory drugs (NSAID). Use of Paracetamol in dog, cat is strictly prohibited. Meloxicam (Strong NSAID) Generic dose: Loading dose- 0.2 mg/kg once, Maintenance dose: 0.1 mg/kg q24h PO/SC/IV. Use in Pregnancy: not safe. Trade name Composition Trade dose Pack size Company Inj. Melovet Meloxicam: 5 mg/ml 1 ml/25 kg BW, SC, single 10 ml vial TECHNO dose. (as 0.2 mg/kg) Inj. Melvet DO DO DO ACME Inj. Camlox Vet DO DO DO Popular Inj. Loxikam DO DO DO OPSONIN Inj. M-Pain Vet DO DO DO ACI Inj. Melocam Vet DO DO DO RENATA Tab. Melobest (pet tablet) Each tablet contains, Meloxicam 2.5 mg 1 tab/12.5 kg, PO 2.5 mg Flunixin Meglumine (Strong NSAID) Generic dose: Dog: 1–2 mg/kg q24h IV/IM/PO upto 3 days. Cat: 0.3-1 mg/kg q24h IM/SC/PO upto 5 days. Use in Pregnancy: Flunixin can be used during pregnancy. Trade name Composition Trade dose Inj. Pif R vet Flunixin Meglumine: 50 Dog: 1 ml/50 kg BW IM/IV mg/ml once daily for 2-3 days (as 1 mg/kg) Inj. Fluximine Do Do Inj. Fixin Vet Do Do Vial size 10 ml vial Company SK+F Do Do Renata ACI Ketoprofen (mild to moderate NSAID) Generic dose: Dog: 1.1–2 mg/kg IV/IM/SC/PO q24h 155 Cat: 1–2 mg/kg SC q24h Use in Pregnancy: safe. Trade name Composition Tab. Keto A Ketoprofen- 50 mg Tab. Kynol Tab. Profenid E DO DO Trade dose 1 tab/25 kg BW, PO, q24h. (as 2 mg/kg) DO DO Pack size 50 mg Company Acme DO DO SK+F Synovia Tolfenamic acid (Mild to moderate NSAID) Generic dose: 4 mg/kg once daily SC, IM or PO for 3–5 days. Use in pregnancy: Tolfenamic acid may be used during pregnancy and lactation. Trade name Composition Trade dose Vial size In. Tamic vet Tolfenamic Acid: 40 1 ml/10 kg BW, IM/SC. q24 10 ml mg/ml h. (as 4 mg/kg) Inj. Fevenil DO DO DO Inj. Tolfavet DO DO Do Inj. Tufnil Vet DO DO Do Inj. Tolfamin DO DO 50 ml Company Acme RENATA TECHNO SK+F GENTRY Carprofen Generic dose: Dog: 4 mg/kg PO, IM, SC once. Cat: 1–4 mg/kg SC/PO pre- or post-operatively. Indications & usage: PK 5 Vet is indicated for rapid relief of Pain, Inflammation & Fever in the following conditions - Bovine Respiratory Disease, Osteoarthritis, Mastitis, Metritis, Soft tissue surgical pain, Post-operative pain, Lameness Use in pregnancy: Safety is not established. Side effects: The most common side effects are diarrhea, vomiting & loss of appetite. Trade Name Composition Trade Dose Pack Company Size Inj. PK5 Vet Each mL injection Dogs: 1 mL/12.5 Kg BW, IM/SC 10 ml SK+F contains Carprofen injection once daily USP 50 mg. Cats: 1 mL/12.5 Kg BW, SC injection once daily (as 4 mg/kg BW) Steroidal Anti-inflammatory Drugs (SAIDs) or Glucocorticoids Contraindication: Pregnancy, gastric ulcer, hypersensitivity to steroids. Dexamethasone Generic dose: Antiinflammation- 0.1–0.2 mg/kg BW IV/IM/PO q12–24h. Shock: 2.2–4.4 mg/kg BW IV. Indication: laminitis, arthritis, bursitis, eczema, dermatitis, induction of parturition and various type of shocks like cardiac shock, septic shock, anaphylactic shock, traumatic shock, hemorrhagic shock etc. Trade Name Composition Trade Dose Pack Company Size 156 Inj. Dexavet Inj. Steron Vet Tab. D cort Tab. Decason Tab. Oradexon Dexamethasone NaPO4: 2 mg/ml Do Dexamethasone- 0.5 mg Do Do 1 mL/20-10 kg BW, IM/IV daily for 3-5 days. Do Human 1 tab/5 kg BW, PO, q12-24h (as 0.1 mg/kg BW) Do Do 10 ml TECHNO 10 ml ACME 0.5 mg tablet Do Do Globe Opsonin Nuvista Prednisolone Generic dose: 0.5–1 mg/kg PO per day Indication: there are four primary uses: 1) replacement or supplementation (e.g., relative adrenal insufficiency associated with septic shock) of glucocorticoid effects secondary to hypoadrenocorticism, 2) as an antiinflammatory, 3) as an immunosuppressive, and, 4) as an antineoplastic agent. Trade Name Composition Trade Dose Pack Size Company Tab. Cortan Prednisolone-2 mg 1 tab/4 kg BW, PO. 2 mg Incepta (as 0.5 mg/kg) tablet Tab. Precodil Do Do Do Opsonin Tab. Pred Prednisolone-10 mg 1 tab/20 kg BW, PO 10 mg SK+F (as 0.5 mg/kg) Tab. Cortan Do Do Do Incepta Tab. Precodil Do Do Do Opsonin Soln . Cortan Prednisolone- 1 1 ml/2 kg, BW, PO 50 ml Incepta mg/ml (as 0.5 mg/kg, BW) Soln. Cortisol Do Do Do Aristopharma Soln. Precodil Do Do Do Opsonin Dexamethasone + Prednisolone Trade Name Inj. Predexanol plus Composition Dose Pack Size Company Each ml contains 0.2-0.6 ml (total dose), 210 ml RENATA Dexamethasone 5 days, IV/IM/SC. Sodium Phosphate + Prednisolone : 2.5 mg + 7.5 mg Indication: Predexanol -S is indicated for the following diseases of Cats and dogs: 1) Skin diseases and disorders affecting the mucosa of the digestive and respiratory tracts. 2) Polyarthiritis Methylprednisolone Generic dose: Dog- 0.22–0.44 mg/kg q12–24h Indication: 1) Replacement of glucocorticoid activity in patients with adrenal insufficiency, 2) as an antiinflammatory agent, 3) as an immunosuppressive. Among some of the uses for glucocorticoids include treatment of: endocrine conditions (e.g., adrenal insufficiency), rheumatic diseases (e.g., rheumatoid arthritis), collagen diseases (e.g., systemic lupus), allergic states, respiratory diseases (e.g., asthma), dermatologic diseases (e.g., pemphigus, allergic dermatoses), hematologic disorders (e.g., thrombocytopenias, autoimmune hemolytic anemias), neoplasias, nervous system disorders (increased CSF pressure), GI diseases (e.g., ulcerative colitis exacerbations), and renal diseases (e.g., nephrotic syndrome). 157 Trade Name Tab. Methigic 2 Tab. Depodrol Composition Methylprednisolone- 2 mg Do Dose 1 tab/ 5 kg BW, PO, q24h (as 0.4 mg/kg ) Do Pack Size 2 mg tablet Do Company Square Opsonin Methylprednisolone Acetate Generic dose: Dog: 1 mg/kg IM q1–3 wk Indication: same as Methylprednisolone Trade Name Composition Inj. DepoMethylprednisolone Medrol 40 mg Acetate- 40 mg/ml Inj. Medrol 40 Do Cat: 10–20 mg (total) IM, q1–3 wk Dose Dog: 1 ml/40 kg, IM Cat: 10–20 mg (total) IM Do Pack Size 40 mg/vial Do Company Janata pharma Techno Brochodilators/ Anti-asthmatic Drugs Trade name Composition Trade dose Vial size Company 100 ml Square Do Acme 100 ml Square Do ACI Generic dose of Bromhexine Hydrochloride- Syp. Mucospel Syp. A-Cod Dog: 2-2.5 mg/kg, PO, q12h. Cat: 1 mg/kg, PO, q24h. Indication: Mucolytics Bromhexine Dog: 2.5 ml /Kg ,PO, q12h. Hydrochloride- 4 (as 2 mg/kg BW) mg/5 ml Cat: 1.25 ml/ Kg, BW, q24h. (as 1 mg/kg BW) Do Do Generic dose of Dextromethorphan Syp. Brofex Syp. Dixer Dog, cat: 1–2 mg/kg, PO q6–8h Indication: Cough suppression/ Antitussive Use in pregnancy: Not safe. Dextromethorphan 1 ml/ 2 kg BW, PO,q6-8h. hydrobromide-2 mg/ml Do Do Generic dose of Aminophylline Dog: 4–8 mg/kg IV or IM, or 6–10 mg/kg PO every 8 hours Cat: 4–8 mg/kg SC, IM, IV q8–12h Indication: Bronchodilator drug with diuretic activity; used for bronchospasm & cardiogenic pulmonary edema Precauition: Intravenous aminophylline should be diluted in at least 100 mL of D5W or normal saline and administered slowly. Use in pregnancy: Not safe. Tab. Filin Aminophylline: 100 1 tab/ 20 kg BW, PO, Bid. 100 mg Opsonin mg/tablet. (as 5 mg/kg) tablet Inj. Filin Aminophylline: 25 1 ml/5 kg BW, IV/IM q12h. 5 ml Opsonin mg/ml (as 5 mg/kg) ampoule Generic dose of Salbutamol (albuterol sulfate) Uses/Indications: Albuterol is used principally in dogs and cats for its effects on bronchial smooth muscle to alleviate bronchospasm or cough. It is also used in horses as a bronchodilator. ✓ Cats: For bronchodilation in feline asthma using the 90 micrograms/puff, 12 hourly ✓ Dog, Cat 0.02-0.05 mg/kg, (20-50 mcg/kg) q6-8h, PO, up to a maximum of 100 mcg/kg q6h. ✓ Use in pregnancy: Not safe. 158 Nebulization Respiratory Solution: Sultolin Salbutamol: 5 mg/ml Inhaler: Brodil HFA Salbutamol: 100 mcg/ puff Salbutamol mix wth Distilled water/NS at 0.1-0.25 ml/2 ml Sig: 0.25 ml sultolin mix with 2 ml NS, then nebulize twice daily for 2-3 days. 1 puff, 12 hourly 20 ml Square 200 metered doses ACI Diuretics Furosemide Uses/Indications: Furosemide is used for its diuretic activity in all species. It is used in small animals for the treatment of congestive cardiomyopathy, pulmonary edema, hypercalcuric nephropathy, uremia, as adjunctive therapy in hyperkalemia and, occasionally, as an antihypertensive agent. Species Dose Route Interval Dog 2–6 mg/kg IV/IM/SC/PO 8–12 h Cat 1–4 mg/kg IV/IM/SC/PO 12 h Use in pregnancy: Not safe. Animal studies have shown an adverse effect on the fetus. Trade name Composition Trade dose Vial size Company Inj. Fusid Furosemide: 10 mg/ 1 ml/10 kg BW IM/IV 2 ml Square ml (as 1 mg/kg) ampoule Inj. Frusin DO DO DO Opsonin Inj. Lasix Inj. G-Frusemide Tab. Fusid DO DO Furosemide: 40 mg DO DO 40 mg tablet Synovia Gonoshasthaya Square DO DO DO 1 tab / 20 kg BW, PO. q12h. (as 2 mg/kg) DO Tab. Lasix DO Synovia Tab. G-Frusemide DO DO DO Gonoshasthaya Mannitol Uses/Indications: Mannitol is used to promote diuresis in acute oliguric renal failure, reduce intraocular and intracerebral pressures, enhance urinary excretion of some toxins, (e.g., aspirin, some barbiturates, bromides, ethylene glycol) and, in conjunction with other diuretics, to rapidly reduce edema or ascites when appropriate. Species Dose Route Interval Dog, cat 1–3 g/kg IV slowly over 30–60 min Use in pregnancy: Not safe. Animal studies have shown an adverse effect on the fetus. Trade name Composition Trade dose Vial size Company Inj. Manisol Each 100 ml contains 100 ml / 20 kg BW, IV. 500 ml bottle Orion (IV infusion) Mannitol- 20 gm BP. (as 1 gm/kg) (20%) Inj. Osmosol Do Do Do Beximco (IV infusion) Inj. Mannitol Do Do Do Opso saline (IV infusion) 159 Drugs Acting on the Gastrointestinal Tract Appetite stimulants & Antidepressant Mirtazapine Generic dose: Dog: 0.6 mg/kg PO q 24 h. Cat: 3–4 mg per cat PO q72h. Uses/Indications: Used in veterinary medicine primarily as an appetite stimulant & antiemetic in dogs & Cats. Can be used in conjunction with other antiemetics. Veterinary uses of mirtazapine include treatment of chemotherapy-induced nausea and vomiting (CINV); anorexia associated with renal failure (azotemia), congestive heart failure, gastrointestinal disorders, liver disease, or neoplasia. Other suggested uses include stress induced diseases; insomnia and post-operative inappetence. Use in pregnancy: Not safe. Trade name Composition Trade dose Vial size Company Tab. Mirapro 7.5 Mirtazapine-7.5 Dog: 1 tab/12.5 kg BW, PO, 7.5 mg Square mg q24h. tablet Cat: half tab/cat, PO, q72h. Tab. Mirez 7.5 DO DO DO Healthcare Tab. Mirtaz 7.5 DO DO DO Sun pharma Gastric secretory inhibitors Famotidine (H-2 blocker also) Generic dose: 0.5–1.1 mg/kg q12–24h IV/SC/PO. Uses/Indications: In veterinary medicine, famotidine may be useful for the treatment and/or prophylaxis of gastric, abomasal and duodenal ulcers, uremic gastritis, stress-related or drug-induced erosive gastritis, esophagitis, duodenal gastric reflux, and esophageal reflux. Trade name Composition Trade dose Pack size Company Inj. Peptid Famotidine- 10 mg/ml 1 ml/ 10 kg BW IV q12h. 2 ml vial Opsonin (as 1 mg/kg) Susp. Peptid Famotidine- 8 mg/ml 1 ml/8 kg BW PO q12-24h. 50 ml Opsonin (as 1 mg/kg) Susp. Famodin Do Do Do Acme Susp. Famotack Do Do Do Square Tab. Famotack Famotidine-20 mg 1 tab / 20 kg BW, oral. 20 mg Square (as 1 mg/kg) tablet Tab. Famodin Do Do Do Acme Tab. Yamadin Do Do Do Beximco Ranitidine ( H-2 blocker also) Generic dose: Dog: 2–4 mg/kg q8–12h IV/ PO. Cat: 2.5 mg/kg q12h IV, or 3.5 mg/kg q12h PO. Uses/Indications: In veterinary medicine, ranitidine has been used for the treatment and/or prophylaxis of gastric, abomasal, and duodenal ulcers, uremic gastritis, stress-related or druginduced erosive gastritis, esophagitis, duodenal gastric reflux and esophageal reflux. It has also been employed to treat hypersecretory conditions associated with gastrinomas and systemic 160 mastocytosis. Because of its effects on gastric motility, ranitidine may be useful in increasing gastric emptying, particularly when delayed gastric emptying is associated with gastric ulcer disease. Ranitidine may also be useful to stimulate colonic activity in cats via its prokinetic effects. Trade name Composition Trade dose Pack size Company Inj. Peptil H Ranitidine 1 ml/ 10 kg BW IV/IM q12h. 2 ml SK+F hydrochloride- 25 (as 2.5 mg/kg) ampoule mg/ml Inj. Ranitid Do Do Do Opsonin Inj. Ranison Do Do Do Jayson Syp. Peptil H Ranitidine 1 ml/5 kg BW PO q12-24h. 100 ml SK+F hydrochloride- 15 (as 3 mg/kg) mg/ml Syp. Neotack Do Do Do Square Syp. Ranidin Do Do Do Acme Proton pump inhibitor Omeprazole Generic dose: 0.5–1 mg/kg PO q24h. Uses/Indications: Omeprazole is potentially useful in treating both gastroduodenal ulcer disease and to prevent or treat gastric erosions caused by ulcerogenic drugs (e.g., aspirin). Omeprazole was superior to famotidine when used to prevent exercise-induced gastritis. Use in pregnancy: Not safe. Animal studies have shown an adverse effect on the fetus. Trade name Composition Trade dose Vial size Company Inj. Losectil Omeprazole- 40 mg/vial 1 ml/4 kg BW IM/IV 40 mg vial + SK+F IV (as 1 mg/kg) 10 ml WFI Inj. Seclo DO DO DO Square Inj. PPI IV DO DO DO Acme Cap. Losectil Omeprazole-20 mg 1 cap / 20 kg BW, PO. 20 mg SK+F (as 1 mg/kg) capsule Cap. Seclo DO DO DO Square Cap. PPI DO DO DO Acme Pantoprazole Generic dose: 0.5–1 mg/kg IV over 15 minutes q24h. Uses/Indications: Pantoprazole may be useful in treating or preventing gastric acid-related pathologies in dogs, cats. Use in pregnancy: safe. Trade name Composition Trade dose Vial size Company Inj. Pantex IV Pantoprazole Sodium 1 ml/4 kg BW IV 40 mg vial + ACI Sesquihyrate- 40 (as 1 mg/kg) 10 ml WFI mg/vial Inj. Pantid IV Do Do Do Opsonin Inj. Pantonix Do Do Do Incepta IV Tab. Pantonix Pantoprazole Sodium 1 cap / 20 kg BW, PO. 20 mg tablet Incepta Sesquihyrate-20 mg (as 1 mg/kg) Tab. Pantid Do Do Do Opsonin Tab. Pantex Do Do Do ACI 20 161 Mucosal cytoprotectants (gastroprotectant) Sucralfate Generic dose: Dog: 0.5–1 g q8h PO. Cat: 0.25–0.5 g q12h PO. Uses/Indications: Sucralfate has been used in the treatment of oral, esophageal, gastric, and duodenal ulcers. It has also been employed to prevent drug-induced (e.g., aspirin) gastric erosions, but efficacy for this is somewhat sporadic. Use in pregnancy: safe. Trade name Composition Trade dose Vial size Company Susp. Ulfate Sucralfate: 1 gm/5 ml 2.5 ml/ kg BW PO. 200 ml Incepta (as 0.5 gm/animal) Susp. Protecto DO DO DO SK+F Tab. Protecto Sucralfate: 500 mg 1 tab / kg BW, PO. q12h. 500 mg SK+F (as 0.5 gm/animal) tablet Tab. Gastalfet DO DO DO Beximco Antiemetics Metoclopramide Generic dose: 0.2–0.5 mg/kg q8h PO, SC or IM; or 1–2 mg/kg/day as a continuous IV infusion. Uses/Indications: Metoclopramide has been used in veterinary species for both its GI stimulatory (Prokinetic drugs) and antiemetic properties. It has been used clinically for gastric stasis disorders, gastroesophageal reflux, to allow intubation of the small intestine, as a general antiemetic (for parvovirus, uremic gastritis, etc.), and an antiemetic to prevent or treat chemotherapy-induced vomiting. Use in pregnancy: safe. Trade name Composition Trade dose Vial size Company Inj. Meclid Metoclopramide 1 ml/10 kg BW IM/SC 2 ml Jayson hydrochloride- 5 mg/ml (as 0.5 mg/kg) ampoule Inj. Motilon DO DO DO Synovia Ondansetron Generic dose: 0.5–1 mg/kg PO q8–12h or 0.1–0.5 mg/kg IV/IM q8h. Uses/Indications: Used as an antiemetic. Use in pregnancy: not safe. Trade name Composition Trade dose Inj. Emistat Ondansetron-2 1 ml/4 kg BW IM/IV mg/ml (as 0.5 mg/kg) Inj. Anset DO DO Inj. Ofran DO DO Vial size 4 ml ampoule DO DO Company Healthcare Opsonin Square Domperidone Generic dose: Cat: 0.05–0.1 mg/kg PO once or twice a day. Dog: 0.1-0.5 mg/kg IV or 0.5-1 mg/kg, PO. Uses/Indications: Domperidone is FDA-approved in the USA for prevention of fescue toxicosis in periparturient mares. It may also be useful as a prokinetic or antiemetic agent in small animals. It has more effect on conditions with delayed gastric emptying than other GI hypomotility conditions. Use in pregnancy: not safe. Trade name Composition Trade dose Vial size Company 162 Susp. Omidon Susp. Motilex Susp. Domilux Paediatric drop. Deflux Paediatric drop. Omidon Paediatric drop. Motigut Domperidone maleate: 1 mg/ml DO DO Domperidone maleate: 5 mg/ml 60 ml bottle DO DO 15 ml bottle DO 1 ml/ 10 kg BW PO. (as 0.1 mg/kg) DO DO 1 ml (20 drops) / 50 kg BW PO. (as 0.1 mg/kg) DO Incepta DO Incepta DO DO DO Square Techno Popular Beximco Carminative/Anti-dyspeptic Drugs Simethicone Uses/Indications: anti-foaming and anti-flatulent agent used to treat discomfort, pain, bloating, burping, and flatulence caused by excessive intestinal gas in dogs and cats. Dose: Cats: 0.3 mL to 0.5 mL every 8 to 12 hours as needed. Dog: 25 mg total dose for small dogs and up to 200 mg total dose for large dogs every 6 to 12 hours as needed. (Dose collected from PetPlace web page) Trade name Composition Trade dose Vial size Company Paediatric drop. Simethicone-67 See the generic. 15 ml Square Flacol mg/ml Paediatric drop. DO DO DO SK+F Gasnil Paediatric drop. Acme DO DO DO Flatunil Laxative agents Docusate sodium Generic dose: Dog: 25–50 mg q24h–q12h PO. Cat: 25 mg q24h PO. Uses/Indications: Docusate is used in small animals when feces are hard or dry, or in anorectal conditions when passing firm feces would be painful or detrimental. Docusate is used alone and in combination with mineral oil in treating fecal impactions in horses. Use in pregnancy: not safe. Trade name Composition Trade dose Vial size Company Tab. Docuset Docusate sodium-120 1 tab / 4 kg BW, PO. 120 mg Opsonin mg q12h. tablet (as 30 mg) Cap. Soflex Docusate sodium-100 1 cap / 4 kg BW, PO. 100 mg Unimed mg q12h. capsule (as 25 mg) Lactulose Generic dose: 0.25-0.5 mL /kg q8–12h PO. Uses/Indications: The primary use of lactulose in veterinary medicine is to reduce ammonia blood levels in the prevention and treatment of hepatic encephalopathy (portal-systemic encephalopathy; PSE) in small animals and pet birds. It is also used as a laxative in small animals. Use in pregnancy: safe. 163 Trade name Sol. Avolose Sol. Avolac Sol. Laclose Composition Lactulose-3.35 gm/ 5 ml DO DO Trade dose 0.5 mL / kg q8–12h PO. Vial size 100 ml Company Team DO DO DO DO Aristopharma Opsonin Magnesium hydroxide /aluminium hydroxide (Oral antacid) Uses/Indications: • Magnesium hydroxide in combination with aluminum salts have been used in veterinary medicine for the adjunctive treatment of esophagitis, gastric hyperacidity, peptic ulcer and gastritis. • Magnesium hydroxide alone (milk of magnesia) is sometimes used as an oral laxative in small animals. Generic dose: Magnesium hydroxide (Milk of Magnesia): 5–15 mL PO once to twice daily Aluminum hydroxide + magnesium hydroxide suspension: 2–10 mL PO q2–4h. Use in Pregnancy: Probably safe. Trade Name Composition Dose Pack Size Company Susp. Mom Each 5 ml contains 5–15 mL PO once to 100 ml Opsonin Magnesium Hydroxide 400 twice daily bottle mg Susp. Acme’s DO DO DO Acme Milk of magnesia Susp. Magmil Do Do Do Pacific Emulsion. Each 5 ml contains DO DO Acme Magvet plus Magnesium Hydroxide 300 mg & Liquid Paraffin 1.25 ml. Emulsion: Frelax Do Do Do Beximco Emulsion. Do Do Do Square Duolax Susp. Entacyd Each 5 ml contains 2–10 mL PO q2–4h. 200 ml Square Magnesium Hydroxide-- 225 mg Aluminium Hydroxide--175 mg Susp. Avlocid Do Do Do Aci Susp. Remacid DO DO DO Reman drug Antidote Trade Name Susp. KOL Composition Activated charcoal: 16.4% Trade Dose 1-2 ml per kg body weight. Repeat dose after 12 hours or as needed, in case of accidental poisoning double the dose & repeat after Pack Size 500 ml bottle Company Reneta 164 every 4-6 hours for 2448 hours. Generic dose of Activated charcoal; Dog, Cat: 1–4 g/kg in 50–200 mL of water. Indications: Used primarily to adsorb drugs and toxins in intestine to prevent their absorption. Ordinarily, a single dose is administered, but multiple doses will increase clearance of drugs that may undergo enterohepatic circulation. Clinical Pharmacology: Activated charcoal is the most valuable single emergency antidote since it acts by inactivating many organic toxicants by adsorption, a surface-active phenomenon. It is considered as universal antidote. It has been determined that charcoal inactivation of a toxicant in gastrointestinal contents, appears to be approximately stoichiometric and dose related in a linear fashion up to 70% to 85%. As a general rule it is safe to assume that 1 gm of activated charcoal will adsorb 70 mg to 90 mg of an ingested organic toxicant. Contraindications: It should not be given simultaneously or shortly before the oral administration of other therapeutic agents such as antibiotics & dewormers. It should be used 2 hours after oral administration of antibiotics & dewormers. Anti-diarrheal drugs Bismuth Subsalilate Generic dose: 0.25 mL/kg BW PO q4–6h or 3 times a day. Uses/Indications: In veterinary medicine, bismuth subsalicylate products are used to treat diarrhea and as a component of “triple therapy” for treating Helicobacter GI infections. Use in Pregnancy: Use with caution in pregnant animals. Trade name Composition Trade dose Vial size Company Susp. Pepto Bismuth Subsalilate0.25 mL/kg BW PO q4– 200 ml Opso 17.5 mg/ml 6h. Susp. Peptocid DO DO DO Incepta Susp. Peptofit DO DO DO Opsonin Loperamide Generic dose: Dog: 0.1–0.2 mg/kg q8–12h PO. Uses/Indications: Loperamide is used as a GI motility modifier in small animals. Some have found that loperamide is useful for treating or helping to reduce chemotherapy-induced (e.g., toceranib) diarrhea in dogs. Use in cats is controversial and many clinicians do not recommend using in cats. Use in pregnancy: safe. Trade name Composition Trade dose Vial size Company Cap. Imotil Loperamide 1 cap / 20-10 kg BW, PO. 2 mg Square hydrochloride- 2 mg q12h. capsule Cap. Lopamid DO DO DO Acme Cap. Normotil DO DO DO Beximco Anti-spasmodic Indication: As antispastic in adjuvant treatment of digestive conditions (abdominal colic, gastric or duodenal ulcer, gastritis, enteritis, colitis, pancreatitis, spastic constipation, meteorism, spasms of cardia and pyloric sphincter, spasms of the biliary smooth muscles, biliary lithiasis, cholecystitis); spasms of urinary tract smooth muscles (renal urethral lithiasis, pyelitis, cystitis); genital disorders (uterine tetanic contractions, severe pains, abortion imminence) in dog, cat, horse and cattle. The spasmolytic action of the product also causes pain killing up to removal. Drug Interaction: Levodopa (anti-perkinson effect may be decreased). Use in Pregnancy and Lactation: There is no known case of teratogenecity in animal studies. However, the use of Drotaverine should be avoided during pregnancy and lactation. 165 Trade Name Inj. Espa-Vet Composition Each ml injection contains Drotaverine Hydrochloride-20 mg. Dose In Dog: 1-2 ml by IM or SC route, 1–2 times/day. In Cat: 0.5 ml–1 ml by IM or SC route, 1–2 times/day. Pack Size 10 ml Company Square Antineoplastic Vincristine sulfate Generic dose: 0.025 mg/kg, IV once weekly for 4-6 weeks of therapy. Uses/Indications: Vincristine is used as an antineoplastic primarily in combination drug protocols in dogs and cats in the treatment of lymphoid and hematopoietic neoplasms. In dogs, it may be used alone in the therapy of canine transmissible venereal tumor (CTVT). Because vincristine can induce thrombocytosis (at low doses) and has some immunosuppressant activity, it may also be employed in the treatment of immune-mediated thrombocytopenia, but efficacy is questionable. Use in pregnancy: not safe. Trade name Composition Trade dose Vial size Company Inj. Criston 1 Vincristine sulfate-1 1 mg/40 kg, IV once 1 mg vial Beacon mg/vial weekly for 4-6 weeks of therapy. (mix with 10-20 ml D.water/NS, then push IV) Inj. Criston 2 Vincristine sulfate-2 2 mg/80 kg, IV once 2 mg vial Beacon mg/vial weekly for 4-6 weeks of therapy. (mix with 10-20 ml D.water/NS, then push IV) Antidiabetic agents Name of drugs Insulin (regular) Insulin (NPH) Insulin (PZI Vet R) Insulin glargine (Lantus R) Lente insulin (Vetsulin R) Ultralente insulin Species Dog, cat Route IM, SC Dose 0.1–0.4 IU/kg q6–8h IV 0.5–1.0 IU/h or 0.025–0.05 U/kg IM Horse Dog Cat Dog Cat Horse Dog IM, SC SC SC SC SC IM, SC SC 0.2 IU/kg once; then 0.1 IU/kg hourly until blood glucose is <250 mg/dL 0.5 IU/kg 0.5–1 IU/kg, q12–24h 1–5 IU/cat q12h 0.5–1 IU/kg q12–24h 1–5 IU/cat q12–24h 0.15 IU/kg 0.25 IU/kg q12h Dog Cat Dog SC SC SC 0.5–1.0 IU/kg, q12–24h 0.5 IU/kg, q12–24h 0.5–1 IU/kg q12–24h (to effect) Notes Diabetic ketoacidosis, mild Diabetic ketoacidosis, Diabetic ketoacidosis, severe Long-acting 166 Metformin (Glucophage R, etc.) Glimepiride (Amaryl R) Glipizide (Glucotrol R) Glyburide (Micronase R) Cat Cattle Cat SC SC PO 1–5 IU/kg q12–24h (to effect) 0.25 IU/kg q4–48h 2–5 mg/kg q12 Sulfonylureas 1–2 mg/cat q24h Cat PO Cat In food 2.5–5 mg/cat q8–12h Cat PO 0.2 mg/kg q24h ➢ (Human trade is available, Follow DIMS app.) Behavior Modifying Drugs Amitriptyline Generic dose: Dog: 2.2–4.4 mg/kg PO, q12–24h Cat: 0.5–2.2 mg/kg PO, q12–24h Indication: Tricyclic “antidepressant” used primarily for behavior disorders & neuropathic pain/pruritus in small animals. Amitriptyline has been used for behavioral conditions such as separation anxiety or generalized anxiety in dogs, and excessive grooming, spraying and anxiety in cats. Amitriptyline may be useful for adjunctive treatment of pruritus, or chronic pain of neuropathic origin in dogs and cats. In cats, it potentially could be useful for adjunctive treatment of lower urinary tract disease. Amitriptyline has been tried to reduce feather plucking in birds. Use in Pregnancy: not safe. Trade Name Composition Dose Pack Size Company Tab. Amilin 10 Amitriptyline 1 tab/ 5 kg BW, PO, 10 mg Opsonin hydrochloride- 10 mg q12-24h tablet (as 2 mg/kg BW) Tab. Tryptin 10 DO DO DO Square Fluoxetine Generic dose: Dog: 1 mg/kg PO q12–24h Cat: 0.5–1 mg/kg PO q24h Uses/Indications: Fluoxetine may be beneficial for the treatment of canine aggression, stereotypic behaviors (and other obsessive-compulsive behaviors), and anxiety. It may be useful in cats for the aforementioned behaviors and, additionally, for inappropriate elimination. Use in Pregnancy: not safe. Trade Name Composition Dose Pack Size Company Cap. Fluoxetine- 20 mg 1 tab/20 kg BW, PO 20 mg Albion Fluoxetine (as 1 mg/kg) tablet Cap. Nodep DO DO DO General Uterine contractants Cabergoline Generic dose: 5–15 mcg/kg q24h for 5d in abortifacient. Uses/Indications: In dogs, cabergoline is used to induce estrus (heat), treatment of anestrus (no estrus), mastitis (breast inflammation), pseudopregnancy (false pregnancy), and as a treatment prior to mammary (breast) tumor surgery. This medicine is also used in both dogs and cats for pregnancy termination in the second half of pregnancy. In pet birds, it may be used for treatment of persistent egg laying. 167 Trade Name Tab. Argolin Composition Cabergoline- 500 mcg Tab. Cabergol DO Dose 1 tab/50 kg PO, q24h (as 10 mcg/kg) DO Pack Size 500 mcg tablet DO Company Opsonin Popular Drugs Acting on the Central Nervous System Anticonvulsants Gabapentin Generic dose: 10–30 mg/kg PO q8h. Indication: Gabapentin may be useful as adjunctive therapy for refractory or complex partial seizures. As an analgesic, gabapentin has been demonstrated to be most useful in treating chronic pain, particularly neuropathic pain in small animals. Use in Pregnancy: not safe. Trade Name Composition Dose Pack Size Company Tab. Gabapen Gabapentin – 300 1 tab/10 kg , BW PO 300 mg Incepta 300 mg (as 30 mg/kg) tablet Tab. DO DO DO Albion Gabapentin 300 Tab. Neuropen DO DO DO Drug 300 Tab. Gabastar Gabapentin – 100 1 tab/5 kg , BW PO 100 mg Square mg (as 20 mg/kg) Tab. Neuropen DO DO DO Drug Tab. Gaba DO DO DO Renata Drugs Acting on Peripheral Nervous System Adrenergic agonists (Catecholamines) Epinephrine (Adrenaline) Generic dose: 10–20 mcg/kg (0.01-0.02 mg/kg) IV/IM/SC Uses/Indications: Epinephrine is employed primarily in veterinary medicine as a treatment for anaphylaxis or cardiac resuscitation. Pharmacology/Actions: Epinephrine is an endogenous adrenergic agent that has both alpha and beta activity. It relaxes smooth muscle in the bronchi and the iris, antagonizes the effects of histamine, increases glycogenolysis, and raises blood sugar. If given by rapid IV injection it causes direct stimulation of the heart (increased heart rate and contractility), and increases systolic blood pressure. If given slowly IV, it usually produces a modest rise in systolic pressure and a decrease in diastolic blood pressure. Total peripheral resistance is decreased because of beta effects. Trade Name Composition Dose Pack Size Company Inj. Adrenaline Adrenaline – 1 1 ml/ 50-100 kg BW, 1 ml Techno mg/ml IV/IM/SC ampoule Inj. Adrinor DO DO DO Incepta Nutritional products Vitamin preparations Vitamin B Complex 168 Mode of action: Vitamin B-complex participate in the formation of enzymes and are indispensable for the metabolism of fats, proteins and carbohydrates and for normal growth of muscular and nervous tissue. Indication: Dogs: Anorexia, emesis, depression, paraparesis, torticollis, circling, convulsions, signs of "Black tongue" or "brown mouth", cheilosis, glossitis, gingivitis, bloody diarrhoea, cardiomyopathy. Contraindication: Diarrhea and other digestive disturbances. Use in Pregnancy and Lactation: is safe in pregnant and lactating animals. Trade Name Composition Dose Pack Company Size Inj. Bional Each ml contains, Dog, cat: 0.5 ml, IM, twice 10 ml Techno Forte Thiamine HCl (B1): 50 mg weekly. 100 ml Riboflavin (B2): 5 mg Nicotinamide (B3): 100 mg Cal-d-pentothinate: 10 mg Pyridoxine HCl (B6): 5 mg cyanocobalamin (B12): 2 mcg Inositol: 2 mg DL-methionine: 5 mg Inj. B50-Vet DO 1-2 ml daily IM injection DO Square for 3 consecutive days in a week. Inj. V-plex vet Inj. Revit B Inj. Beco Vet Each ml contains Thiamine HCl (B1)--25 mg Riboflavin (B2)--2 mg Nicotinamide (B3) --50 mg D-Panthenol (B5 )—2.5 mg Pyridoxine HCl (B6)--5 mg Each mL contains Thiamine HCl (B1)—25 mg Riboflavin (B2)—1.5 mg Nicotinamide (B3 )—50 mg Pyridoxine HCl (B6)--5 mg cyanocobalamin (B12)— 50 mcg Each ml contains Thiamine HCl (B1)--25 mg Riboflavin (B2)--2 mg Nicotinamide (B3) --50 mg D-Panthenol (B5 )—2.5 mg DO DO Acme DO 10 ml 50 ml 100 ml Opsonin DO 10 ml 100 ml Popular 169 Pyridoxine HCl (B6)--5 mg Cyanocobalamin (B12)-500 mcg Syp. B50 Forte Syp. Uniplex Syp. V Plex Human syrup Vitamin B Complex Dog: 1-2 teaspoonfuls 1-2 times daily Cat: ½ -1 teaspoonfuls 1-2 times daily DO DO Do Do 200 ml Square 100 ml Do Aristopharma Acme Nerve tonics Indication: Vit B1 deficiency, Nerve damage, Paralysis. Neuro-B® is a combination of Thiamine (Vit-B1), Pyridoxine Hydrochloride (Vit-B6) & Cyanocobalamin (Vit-B12). These vitamins play an essential role as co-enzyme in the cellular biochemical metabolism in the nervous system. Thus the combination normalizes metabolic condition of nerve cell and improves its condition. Neuro-B supports the regeneration of nerve fibers and myelin sheath be activation of the metabolism & the natural repair mechanism. Use in pregnancy: No sufficient data available. Trade name Composition Trade dose Vial size Company Inj. Neuro B Inj. Neuro best Inj. Myelin Tab. Neuro B Tab. Neuro best Tab. Vitabion Tab. Solbion Inj. Nervin Each 3 ml contains, Thiamin mononitrate (B1): 100 mg Pyridoxin HCl (B6) : 100 mg, Cyanocobalamine (B12): 1 mg DO DO Each tablet contains, Thiamin mononitrate (B1): 100 mg Pyridoxin HCl (B6) : 200 mg, Cyanocobalamine (B12): 200 mcg DO DO DO Each 2 ml contains, Thiamin mononitrate (B1): 100 mg, Riboflavin (B2): 50 mg, Pyridoxin HCl (B6): 100 mg 1 ml/10 kg BW, IM. 3 ml ampoule SQUARE DO DO 1 bol/10 kg BW, PO. DO DO Renata Opsonin SQUARE DO DO DO 1 ml/10 kg BW, IM/IV. Renata DO 2 ml ampoule Incepta SK+F JAYSON Vitamin C Generic dose: Cat-30 mg/kg PO/SC q6h or 20 mg/kg, IV q6h. Indications: Vitamin C is used for tissue repair and collagen formation. It may be involved with some oxidation-reduction reactions, and with the metabolism of many substances (iron, folic acid, norepinephrine, histamine, phenylalanine, tyrosine, some drug enzyme systems). Vitamin C is 170 believed to play a role in protein, lipid and carnitine synthesis, maintaining blood vessel integrity and immune function. Trade Name Composition Trade dose Pack Size Company Syp. Ascoson Ascorbic acid- 20 1 ml/kg BW, PO 100 ml Jayson mg/ml (as 20 mg/kg) Syp. Ceevit DO DO DO Square Syp. Livit-c DO DO DO Orion Tab. Mega-C Ascorbic acid- 250 1 tab/10 kg BW, PO 250 mg Edruc Ltd 250 mg (as 25 mg/kg) tablet Tab. Ceevit DO DO DO Square 250 Tab. Ascoson DO DO DO Jayson 250 Vitamin E Generic dose: 10–15 Units/kg per day PO {1 IU = 0.9 mg for dl-alpha-tocopherol (synthetic), hence, 11 IU= 9.9 mg } Indications: Lipid-soluble vitamin (E) with or without selenium used alone for discoid lupus erythematosus, canine demodicosis, acanthosis nigricans, hepatic fibrosis, or adjunctive therapy of exocrine pancreatic deficiency or hepatopathy in dogs & cats; used in combination for seleniumtocopherol deficiency (white muscle disease) Vitamin E is an antioxidant and is necessary for the normal function of muscular tissue. Trade Name Composition Trade dose Pack Size Company Tab. E-cap Vitamin E (Alpha1 tab/20 kg BW, PO 200 mg Drug tocopherol)- 200 (as 10 mg/kg) tablet mg Tab. E-200 DO DO DO Bristol Tab. Ovit E DO DO DO Opsonin Vitamin E + Vitamin C Indications: Vitamin E Helps neutralize free radicals that cause damage. Vitamin C In-activates free radicals, Regenerates vitamin E, restoring its antioxidant activity. Trade Name Composition Trade dose Pack Size Company Tab. EC plus Vitamin E + 1 tab/ 10 kg BW PO 200 + 200 Orion Vitamin C : 200 + mg 200 mg (as 10 + 30 mg/kg) Tab. Protector Vitamin E + DO DO Opsonin Vitamin C : 250 + 200 mg Cap. E-Cap DO DO DO Drug Plus Vitamin K Generic dose: 1–5 mg/kg PO or SC q24h Pharmacology/Actions: Vitamin K1 is necessary for the synthesis of blood coagulation factors II, VII, IX, and X in the liver. It is believed that Vitamin K1 is involved in the carboxylation of the inactive precursors of these factors to form active compounds. Use in pregnancy: Not known Trade Name Composition Trade dose Pack Size Company Inj. Dinakion Phytomenadione1 ml/ 10 kg BW SC, q24h 10 mg Chemist 10 mg/ ml (as 1 mg/kg) ampoule 171 Inj. K MM Inj. K-one DO DO DO DO DO DO Incepta Square Multivitamin & Multimineral preparations Indications: Indicated for the prevention and treatment of vitamins and minerals deficiencies, chronic diseases, infection illness, osteoporosis, surgery, poor digestion, old Age, pregnancy and lactation, poor appetite etc. Cod liver oil is an excellent source of vitamin A and vitamin D. Vitamin A is a vital nutrient for immune system function, cellular growth, eye health, and reproduction. It’s also rich in omega-3 fatty acids, which decrease blood clot formation and reduce inflammation in the body. Use in pregnancy & lactation: safe. Trade Name Composition Trade dose Pack Size Company Syp. Zovia MultivitaminDog: 1-2 teaspoonfuls 1-2 100 ml Opsonin GOLD Multimineral. times daily Cat: ½ -1 teaspoonfuls 1-2 times daily Syp. Livwel Do Do Do Square Syp. Aristo Kid Do Do Do Aristopharma Syp. Nutrum Do Do Do Acme Junior Syp. Filwel Vitamin A, D, B1, Do Do Square Kids B2, B6, C, E, Nicotinamide, Cod liver oil (Multivitamin with Cod Liver Oil) Syp. Multi Do Do Do General Seas Syp. Pogo Do Do Do Healthcare Syp. Zovia Kids Do Do Do Opsonin Mineral preparations Calcium Carbonate Indications: Calcium carbonate is used as an oral calcium supplement for hypocalcemia, sometimes used with vitamin D supplements or calcitriol. It is used as antacid to treat gastric hyperacidity and GI ulcers and as an intestinal phosphate binder for hyperphosphatemia associated with renal failure. Generic dose: 70-185 mg/kg/day given with food PO. (https://veteriankey.com/c-2/ ) Trade Name Composition Trade dose Pack Size Company Tab. Calbo Calcium carbonate-500 1 tab/5 kg BW, PO q24h 500 mg Square mg (as 100 mg/kg) tablet Tab. Oracal Do Do Do Amico Tab. Acical Do Do Do Aci Calcium Carbonate + Vitamin D Generic dose of cholecalciferol: Dog- 22-275 IU/kg BW Trade Name Composition Trade dose Tab. Calbo D Calcium As per instruction Carbonate- 500 mg Or Vitamin D- 200 IU Dog- 1-2 tablet per day, PO Cat- Pack Size Company Square 172 Tab. Acical D Tab. A-Cal D 1⁄ parts of a tablet for 5 kg BW 2 1⁄ 𝑜𝑟 1⁄ parts of a tablet for 2-4 4 3 kg BW 1⁄ 𝑜𝑟 1⁄ parts of a tablet for 0.5-2 6 5 kg BW DO DO DO DO DO DO Aci Acme Zinc preparations Indication: is indicated for inappetance, diarrhoea, poor growth, alopecia, dermatitis, swollen feet, wounds failed to heal properly, wool-eating, stiffness of the joint, impaired reproduction, immunologic dysfunction, reduced production etc. Generic dose: Zinc Sulphate Monohydrate- 5–10 mg/kg BW, q12h,PO, daily. As an appetite stimulant: 1 mg/kg PO once a day. Drug Interaction: Should not be taken at the same time as the antibiotic (tetracycline) because it interferes the absorption & effectiveness of this medication. Trade Name Composition Trade dose Pack Size Company Syp. Zesup- vet Each 5 ml syrup contains Dog: 1-2 teaspoonfuls 1-2 100 ml SQUARE Zinc Sulphate times daily Monohydrate—10 mg. Cat: ½ -1 teaspoonfuls 1-2 times n Sol . Xinc-Care DO Do 200 mL SK+F Liq. Azinck vet DO Do 100 ml ACI Human preparation Syp. Orazinc Do Do Do Navana Syp. Xinc Do Do Do SK+F Syp. Zesup Do Do Do Square Tab. Xinc Zinc Sulphate 1 tab/4 kg BW, PO 20 mg SK+f Monohydrate—20 mg. (as 5 mg/kg bw) tablet Tab. Pep Do Do Do Orion Tab. Zincare Do Do Do Jayson Vitamin B Complex + Zinc Trade Name Syp. Bicozin Composition Zinc + Vitamin B Complex Syp. Kidzinc-B Syp. Xinc B Do Do Trade dose Dog: 1-2 teaspoonfuls 1-2 times daily Cat: ½ -1 teaspoonfuls 1-2 times Do Do Pack Size 100 ml Company Square Do Do Virgo SK+F Amino Acid (Amino acids, dextrose, electrolytes & vitamins) Indication: Aminovit Plus Vet help in protein formation. It acts as building blocking agent for the development of meat production. It also use for the milk production. For use as a supplemental source of dextrose, electrolytes, vitamins and amino acids for all animals. Supporting therapy on the operation and after operation, convalescing, dehydration weakness, vomiting, diarrhea, imbalance of electrolytes, ketosis, anaphylaxis, acidosis and hypoproteinemia. Use in Pregnancy and Lactation: No ingredients in the product have been shown to produce reproductive effect. Safe in lactating period of animals. 173 Trade Name Composition Trade dose Inj. Amino vit plus Each 100 ml contains Dextrose BP 5.0 g Calcium Chloride BP 0.2 g Potassium Chloride BP 0.2 g Magnesium Sulphate BP 0.2 g Sodium Acetate BP 0.75 g L-Histidine USP 0.002 g L-Methionine USP 0.0525 g L-Tryptophan USP 0.0175 g L-Cystine BP 0.002 g L-Threonine USP 0.035 g L-lsoleucine USP 0.0525 g L-Arginine USP 0.1425 g L-Phenylalanine USP 0.035 g L-Valine USP 0.0525 g L-Lysine Hydrochloride USP 0.0525 g L-Leucine USP 0.06 g Monosodium Glutamate USP 0.008 g Riboflavin BP 0.005 g D-Pantothenol BP 0.01 g Pyridoxine Hydrochloride BP 0.01 g Nicotinamide BP 0.3 g Thiamine Hydrochloride BP 0.01 g Each 100 ml injectable solution contains: L-Lysine – 170 mg. L-Methionine – 51 mg L-Threonine – 78.2 mg, L-Tryptophan – 34 mg, L-Arginine – 142.5 mg, L-Leucine – 187 mg L-Isoleucine – 85 mg L-Valine – 136 mg, L-Phenylalanine – 119 mg, Glycine – 375 mg, Sodium L-Glutamate – 375 mg Vitamin B1 –10 mg, Vitamin B2 – 5 mg. Vitamin B6 –10 mg. Vitamin B12 – 5 mcg, Calcium Pantothenate–10 mg. Nicotinamide–300 mg. Sodium Acetate Trihydrate– 750 mg. For Dog & other animals: Inj. Aminomax Vet 1 ml per 10 kg body weight. Inject intramusculary, intravenously or subcutaneously. Do Pack Size 20 ml vial 50 ml, 100 ml, 250 ml 500 ml bottle. Company 50 ml 100 ml Vial Globe Popular 174 Soln. Aminovit plus Vet Calcium Chloride Dihydrate– 200 mg, Potassium Chlonde – 200 mg. Magnesium Chloride Hexahydrate –200 mg, Glucose – 5000 mg Each 100 ml contains Dextrose BP 5.0 g Calcium Chloride Dihydrate BP 0.265 g Potassium Chloride BP 0.2 g Magnesium Sulphate Heptahydrate BP 0.410 g Sodium Acetate Trihydrate BP 1.244 g L-Histidine USP 0.002 g L-Methionine USP 0.0525 g L-Tryptophan USP 0.0175 g L-Cystine BP 0.002 g L-Threonine USP 0.035 g L-lsoleucine USP 0.0525 g L-Arginine USP 0.1425 g L-Phenylalanine USP 0.035 g L-Valine USP 0.0525 g L-Lysine Hydrochloride USP 0.0525 g L-Leucine USP 0.06 g Sodium Glutamate INN 0.008 g Riboflavin Sodium Phosphate BP 0.0095 g D-Pantothenol BP 0.01 g Pyridoxine Hydrochloride BP 0.01 g Nicotinamide BP 0.30 g Thiamine Hydrochloride BP 0.01 g 100 ml, Popular Normal dose: 2-3 ml per 10 kg body weight in drinking water. Omega-3 fatty acid Indication: Used for treatment of dogs with pruritus associated with atopy, idiopathic seborrhea; in cats for pruritus associated with miliary dermatitis & eosinophilic granuloma complex; may be useful in cats with heart failure. Fatty acids may improve coat quality and be helpful for adjunctive therapy for arthropathies such as hip dysplasia. Antihistamine and fatty acid therapy may be synergistic for treatment of pruritus. Generic dose: Eicosapentanoic acid- 30-40 mg/ kg BW, PO, daily. Adverse Effects: At high dosages, GI disturbances (e.g., vomiting, diarrhea) may be seen. Rarely, some dogs become lethargic or more pruritic. Use in Pregnancy: Safe use in pregnancy has not been established. Use cautiously. Trade Name Composition Dose Pack Size Company 175 Cap. OMG-3 Omega-3 fatty acid-1 gm Do 1 gm/25 kg BW, PO. 1 gm Drug (as 40 mg/kg) capsule international Cap. Neomega Do Do Opsonin Veterinary Petme Plus Omega 3, 6 & vit E + Dogs and cats under 10 Kg, 30 gm Gel Prebiotic + Taurine feed directly 1 teaspoon every 4-6 hours. Dogs over 15 Kg, feed directly 2 teaspoon every 4-6 hours. (1 teaspoon is about 6 g.) Indication : Petme Plus Gel is the best for sick and poor condition of dogs and cats, anorexia, malnutrition. Especially for rapidly growing young pets, periods of gestation or lactation, recovery following illness and surgery, or maintenance of healthy skin and coat. Liq. CAT STAR SkyEC Each 10 ml contains Kitten (over 8 weeks): 100 ml Omega 3,6,9 fatty 1.5 ml twice daily (multivitamin acids: 6800 mg Adult cat: 2.5-5 ml twice daily & coat tonic) L-taurine: 100 mg Give directly to the mouth or Biotin: 100 mcg mix in food or water Zinc: 10 mg Vitamin A: 1800 IU Vitamin D3: 200 IU Vitamin E: 20 IU Uses: Cat Star Multivitamin & Coat tonic is indicated for….. ✓ Improves growth and development ✓ Helps in preventing excessive hair loss ✓ Helps in gaining normal condition in weak and sick animals ✓ For better eyesight ✓ As a supplement in all types of skin-related diseases. ✓ Helps in appetite stimulation. ✓ Maintains overall health and improves immunity. Liq. Furglow Furglow contains Pups Small Breeds:- 1.5-2.5 200 ml Himalaya Wellness plant derived oils ml twice daily. (Oral coat Company that are rich in Pups Large breeds:- 3- 5 ml conditioner) Omega 6 and Omega twice daily. 3 fatty acids. Adults Small breeds:- 5-10 ml + twice daily. Zinc Adults Large breeds:- 10-15 ml twice daily. Cats:- 2.5 -5 ml twice daily Uses: ✓ Shiny and glossy coat ✓ Hair shedding, flaky skin and dandruff ✓ Allergic skin conditions like flea bite, atopy ✓ Fungal skin infection and pyoderma Liver tonics Indication: 176 ✓ ✓ ✓ ✓ Helps in regeneration of liver Overcome deficiency of vitamin Increases function of liver in case of indigestion & infectious diseases Gives extra energy & repair liver immediately in case of infection when stored vitamins & energy sources are decreased. ✓ Choline chloride, vitamin- B12, liver extract, inositol prevent fatty change of liver. Sometimes remove excess fat from the liver. ✓ The B-vitamins are components of enzyme system, which needed for metabolism of carbohydrate, fat & protein. Trade Composition Dose Pack Size Company Name Liq. FurLiv Tricholine citrate 200 ml Wiggles Dogs 10-20 ml Protein hydrolysate, Vitamin twice B12, Inositol, Methyl donors Puppies 5-10 ml twice Selenium, Vitamin E, Biotin Cats & 2-5 ml twice kittens FurLiv-Liver Protector Furliv improves your pet's appetite and maintains their energy levels. It keeps the liver and your pet stress-free, healthy and stimulates metabolism too. Promotes growth, aids in Vitamin-E absorption, protects liver and acts as an antioxidant. Therapeutic and does not clash with any other medications. Liq. Caper Bush, Chicory Dogs(Small breeds): 5-8 ml 200 ml Himalaya Himalaya twice daily Liv.52 Dogs(Large breeds): 10-15 ml twice daily Cats: 3-5 ml twice a day for 1-3 months Himalaya Liv.52 Forte Vet is used as an adjuvant in anorexia, dysfunction and liver injury, ascites and jaundice, toxicity associated with drugs and pesticides, canine and feline viral hepatitis, but also Parvovirus infection. Tab. Do Oral administration as 60 Himalaya Himalaya follows: tablets Liv.52 Forte Small dogs: 1 tablet twice a day for 1-3 months Large dogs: 2 tablets twice a day for 1-3 months Cats: 1 tablet once a day for 1-3 months Syp. Hepamust syrup contains 15 Up to 5 kg body weight: Mankind Hepamust unique herbs. 2.5 ml or 0.5 tsp two to Pharma Each 100 ml contains: three times daily Silybum marianum – 3.75%, Tephrosia purpurea –2.50%, Can be mixed with the food Solanum nigrum – 1.50%, / water or can be given Edipta alba –1.50% directly. Tinospora cordifolia –1.50%, Centella asiatica – 1.50% Cichorium intybus – 1.50%, Phyllanthus niruri – 1.50%, Fumaria parviflora – 1.25%, 177 Cassia occidentalis – 0.75%, Berhavia diffusa – 0.75%, Terminalia arjuna –0.75%, Terminalia chebula – 0.38% Embelia ribes – 0.75% Ocimum sanctum – 0.10% Syrup base. Indication / Uses of Hepamust: Liver disorders of idiopathic origin, Drug induced toxicity, Along with Dewormer & Antibiotic therapy, Debility, Anorexia / Poor Digestion, Hepatitis (Jaundice), Fatty liver syndrome, For rich hair coat and healthy skin. Syp. Each 5 ml syrup contains Dog: 1-2 teaspoonfuls 2-3 100 ml Drug Hazmina extract of times daily. Interna Piper nigrum 150 mg, Cat: ½ -1 teaspoonful 2-3 tional Trachyspermum times Daily Ammi-100 mg, Citrus aurantifolia-100 mg, Cinnamomum zeylanicum50 mg, Emblica officinalis-50 mg, Terminalia belerica-38 mg, Terminalia chebula38 mg, Zingiber officinale-10 mg, Sea salt-8 mg and other ingredients QS. Liq. Ergoliv Rohitakarist 1-2 ml/10 kg bw, PO, BID. 200 ml Ergon Pharmac eutical Liq. Liva vit Each Litre containsDo 100 ml, SQUARE Vitamin B1--5,000 mg Vitamin B2--2,000 mg Vitamin B5--11,000 mg Vitamin B6--2,000 mg Vitamin B12--10,000 mcg Vitamin K3--650 mg Folic Acid--300 mg Nicotinamide--60,000 mg Inositol--1,000 mg Cholin Chloride--50,000 mg DL-Methionine--50,000 mg Liver extract--200 mg Liq. Renaliv Livertonic Do 250 ml RENATA Liq. 500 ml, ACME Do প্রহত্ ১০০ হম. হল. ভত্ রটয়টছHepatovet আফানাহমক্সিস হলস্টাহচয়া- ২০০ হম. গ্রা. োরহমনাহলয়া ভচবুলা- 800 হম. গ্রা. হরয়াম এটমাহি- ২৫০ হম. গ্রা. এনটরাগ্রাহফস ভ হনকুলাো- ২০০০ হম. গ্রা. বারটবহরস এহরসোো-800 হম. গ্রা. ও অনযানয ভেষজ উ ািান এবং 178 হেোহমন হব১- ১৫ হম. গ্রা. হেোহমন হব- ৫. ৮ হম. গ্রা. হনটকাষ্টেনামাইি- ৮৪ হম. গ্রা. হেোহমন হব১২- ১০ হম. গ্রা. ইটনাহসেল- ২০০ হম. গ্রা. ভকাহলন বাইোরটেে- ৫ হম. গ্রা. Liq. Hepafit Vet Liq. Hepa Amine Liq. Livaplex Liq Heparen Liq. Hepacef Gold Soln. Restoliv Each ml contains Sorbitol-500 mg, Sodium (Chloride)-19 mg, Magnesium (Chloride)3.045 mg, Methionine hydroxy analogue-18.25 mg, Choline (Chloride)-80 mg, LCarnitine-25 mg, Betaine (HCl)-30 mg & Vitamin PP (B3)-2 mg. Betain HCl: 60 gm Acetyl methionine: 100 gm Choline chloride: 75 gm D-Sorbitol: 350 gm L-Lysine: 20 gm Herb extract: qs to 1L Choline chloride, yeast extract, Vit B1, B6, B12, K, liver extract, niacin, DLpantothenic acid, inositol, folic acid Levocarnitine- 1 gm Choline chloride-3.5 gm Each 30 ml contains Silymarin-160 mg, Nicotinic Acid-20 mg, Nicotinamide-45 mg, Ferrous Gluconate-225 mg, Ferrous Chloride-80 mg, Thiamin Hydrochloride-7 mg, Riboflavine-7 mg, Calcium Lactate-350 mg, Liver Fraction-2150 mg. Each ml contains , Carnitine HCl- 25 mg DL-methionine- 10 mg Choline chloride- 18.75 mg Magnesium sulphate-10 mg Sorbitol (E420)- 200 mg Cynarine (antichoke extract)-5 mg Carriers and preservativesQS Do 100 ml, bottle. Acme Do 100 ml ACI Do 100 ml, POPULAR Do 100 ml bottle 100 ml 1L RENETA Do Do SQUARE OPSONIN 100 ml 179 Soln. Hepatonic Liq. Renaliv Each liter solution contains: Methionine 50.00 gm Choline Chloride 190.00 gm Inositol 2.50 gm Biotin 0.25 mg Vitamin B2 200.00 mg Herbal liver tonic Do 100 ml, SK+F Do 250 ml Renata Hematinic mixtures Mode of action: Haematinic mixture usually stimulates liver and bone marrow to produce blood. Indication: It acts as an effective appetite stimulant, for prevention and treatment of iron deficiency, anemia etc. This is also indicated in case of ruminal stasis resulting from metabolic and infectious diseases in cattle, buffaloes, sheep & goat. Contraindication: Diarrhoea, hypervitaminosis. Trade Name Generic Name Dose Pack Size Company Inj. Hemovit Each ml contains: intramus-cular or 10 ml RENATA Thiamine hydrochloride--75 intravenous route. 100 ml mg Riboflavin 5-phosphate Small Animals: 0.5 to 1 sodium—2 mg ml every 48 hours. Pyridoxine hydrochloride--5 The dose should be mg Continued for 2-3 days. Niacinamide--100 mg d-Pantothenol--20 mg Vitamin B12--120 mcg Ferric ammonium citrate— 15 mg Cobalt gluconate-0.70 mg Copper gluconate--0.20 mg Inj. V-plex vet Do IM route 10 ml, ACME plus Small animal: 0.5-1 ml 100 ml injection for every 48 vial hours, 2-3 days. Soln. Ferovet Each 100 ml contains, 1 ml/kg, PO, BID for 5-7 100 ml ACME Iron- 50 mg days Copper - 20 mg Cobalt - 10 mg Zn -20 mg B12 -10 mg Soln. Feromin Do Do 500 ml Gentry Vet Iron dextran Iron dextran is used in the treatment and prophylaxis of iron deficiency anemias, primarily in neonatal food-producing animals. Generic Dose: Dog, Cat-10–20 mg/kg once, IM Use in Pregnancy: High dosages may cause increased incidences of teratogenicity and embryotoxicity. Inj. Irondex Each ml Injection Solution Dog & Cat: 1.5-2.5 ml for 10 ml, Bridge (vet) contains-3-5 days intramuscularly. 50 ml 180 Iron Dextran USP-100 mg Cyanocobalamin (B12)-100 mcg. Inj. HemproVet (vet) Each ml contains, Iron Hydroxide Dextran Complex- 100 mg Do 10 ml SQUARE Syp. Compiron Each 5 ml of syrup contains Iron (III) Hydroxide Polymaltose Complex INN 200 mg equivalent to 50 mg of elemental iron. Do Dog: 5-10 ml once or twice daily Cat: 2-5 ml once or twice daily 100 ml 200 ml Incepta Do Do ACI Syp. Polyron Ferrous sulfate Primarily to the treatment of iron-deficiency anemias in dogs (usually due to chronic blood loss), and as adjunctive therapy in cats when receiving epoetin (erythropoietin) therapy. Generic Dose: Cat: 10 mg/kg PO once daily or 50–100 mg (total dose) PO per day Dog: 100–300 mg (total dose) PO once a day Use in Pregnancy: safe. Syp. G Iron Ferrous sulphate-200 mg/ml 1 ml/20 kg, PO once, 200 ml Gonoshas daily. thaya Syp. Apitone Do Do Do Apollo Syp. Do Do Do Beximco Aristoferon Cyanocobalamin + Elemental Iron + Folic Acid Syp. Zimon plus Syp. Ediplex ZI Primarily to the treatment of iron-deficiency anemias Each 5 ml contains, Dog: 1-2 teaspoonfuls 1-2 60 ml B12- 25 mcg times daily Iron- 100 mg Cat: ½ -1 teaspoonfuls 1Folic acid- 1 mg 2 times Do Do 100 ml 200 ml Zenith Edruc Electrolytes See farm animal medicine, page- 116 Fluid therapy (IV Infusion) See farm animal medicine , page- 118 Kidney Tonic Citrate salts (Potassium citrate, Sodium citrate and citric acid) Uses/Indications: Citrate salts serve as source of bicarbonate; they are more pleasant tasting than bicarbonate preparations making them more palatable. They are used as urinary alkalinizers when an alkaline urine is desirable and in the management of chronic metabolic acidosis accompanied with conditions such as renal tubular acidosis or chronic renal insufficiency. Potassium citrate alone has been used for the prevention of calcium oxalate uroliths. The citrate can complex with calcium 181 thereby decreasing urinary concentrations of calcium oxalate. The urinary alkalinizing effects of the citrate also increase the solubility of calcium oxalate. Pharmacology/Actions: Citrate salts are oxidized in the body to bicarbonate thereby acting as alkalinizing agents. The citric acid component of multi-component products is converted only to carbon dioxide and water and has only a temporary effect on systemic acid-base status. Generic Dose: Dog- Potassium citrate: 40–75 mg/kg PO q12h Cat- Potassium citrate: 50-100 mg/kg PO q12h or 50–100 mg kg PO q12h Use in Pregnancy: Not safe. Trade Name Generic Name Dose Pack Size Company Tab. Urilit Potassium citrate-1080 mg 1 tab/18 kg BW,PO, q12h 1080 mg Opsonin (as 60 mg/kg) tablet Soln . Urokit Each 5 ml contain, Dog: 10-15 ml, PO 200 ml Sk+F Plus potassium Citrate-1500 mg diluted with 1 glass/cup & Citric Acid- 250 mg of water & feed whole day in little. Cat: 3-5 ml, PO diluted with 1 glass/cup of water & & feed whole day in little. Soln. Uriset Do Do Do Square n Sol . Urinor Do Do Do Novelta Veterinary Liq. UTIKID Tribulus terrestris (SD) : 250 Puppies below 5 kg: 5 ml 200 ml SkyEc mg daily Pharma (a supplement Zingiber officinale (RZ) : 100 for kidney mg Adults: 5 ml/10 kg body health in dogs Piper nigrum(SD) : 100 mg weight daily and cats.) Piper longum (SD) : 100 mg Terminalia chebula (SD) : Cats : 2.5 ml twice daily 100 mg Terminalia bellerica (SD) : Give directly into mouth 100 mg or mix in food or water Phyllanthus emblica (SD) : 100 mg Arctostaphylos uva-ursi (SD) : 75 mg Petroselinum crispum (PT) : 75 mg Althaea officinalis(RT) : 75 mg Syzygium aromaticum: 50 mg Thiamine (Vitamin B1): 6 mg Riboflavin (Vitamin B2): 6 mg Pyridoxal 5-Phosphate (Vitamin B6) : 12 mg Cyanocobalamin (Vitamin B12) : 75 mcg Folic Acid (vitamin B9) : 0.25 mg 182 Potassium (Potassium Gluconate) : 12 mg L-Arginine: 80 mg Choline: 6 mg Eicosapentaenoic Acid (EPA) : 32 mg Docosahexaenoic Acid (DHA) : 14.4 mg Benefits ✓ UTKID Kidney Support Supplement contains 11 herbal blends along with B complex vitamins, minerals, amino acids & omega 3 fatty acids Utkid syrup is indicated for ✓ Given in chronic kidney disease (CKD) ✓ Renal failure. ✓ Prevents & Dissolves the formation of uroliths (calculi or stones). ✓ Clinically proven Supplement to dissolve struvite stones & and improve Urinary health. Haemostats Indication: External and internal haemorrhage. Generic dose: ✓ Tranexamic acid: 10 mg/kg BW, IM/IV/SC. ✓ Aminocaproic acid: 20 mg/kg BW Trade Composition Trade dose name Inj. Tracid Tranexamic acid: 100 For intramuscular, subcutaneous & Vet mg/ml intravenous administration. Dogs, Cats and Pigs: 1 ml/7-10 kg body weight (10-15 mg/kg) once or twice daily. As an Emetic Dogs and Cats: 1 ml/4 kg body weight (25 mg/kg) by rapid 1.V injection. Human preparation Inj. Anaxyl DO 1 ml/10 kg BW, slow IV injection Inj. Enclot Inj. Hemosin Inj. Caprolex DO Aminocaproic acid: 1 gm/5 ml DO DO 1 ml/10 kg BW, single dose IV, orally, locally DO Vial size Company 10 ml vial Acme 5 ml ampoule DO 5 ml ACI Opsonin Chemist 5 ml, Techno Atropine preparations Mode of action: Inhibit the muscarinic receptor Generic dose: 0.02 to 0.04 mg/kg, IM/IV/SC but IM and IV routes are preferred for better uptake. Indication: ✓ to control excessive bronchial & gastric secretions, hypermotility of intestinal smooth muscle, secretory dirrhoea and excessive salivation ✓ as an antidote for organophosphate (insecticides) or muscarinic mushroom intoxication ✓ for treatment of bronchoconstrictive diseases Contraindication: Heart failure, cardiomyopathy, glucoma, pre-existing tachycardia. 183 Use in Pregnancy: not safe. Trade name Composition Inj. Tropin vet Each ml injectable solution contains Atropine Sulphate BP 1 mg Inj. Atrovet Do Dose Treatment IM/SC use only. Dog/Cat: 0.3-0.5 ml/10 kg body weight Do Pack size 10 ml vial Company ACME Do Techno Vial size Company ACI Pet care Trade name Syp. PAZinc plus Composition Trade dose ✓ ✓ ✓ ✓ কুকুর ও হবডাল : 100 ml Aci ভছাে প্রাহির জনয (২ সপ্তাি – ১ মাস বয়স): ৩ হমহল মাোহর প্রাহির জনয (১-৬ মাস বয়স): ৪ হমহল বড প্রাহির জনয (৬ মাস বয়স এর ভবশী): ৫ হমহল খাবার াহনটত্ ওষু প্রটয়াটগর ২৪ ঘন্টার মট য বযবিার করা উহচত্। ছিলদেশিাঃ অসুস্থত্া এবং কটলর হবরুটে সুরক্ষা প্রিাটন কাযকর ম ইহমউহনষ্টে বৃক্সে এবং এহন্ট বহি তত্হরর মা যটম ক্ষহত্কর োইরাস ও বযাকটেহরয়া ভথটক সুরক্ষা প্রিান কটর অহত্হরক্ত শম ডা ভরা কটর। ত্ু ক সংক্রান্ত সমসযা সমা াটন কাযকার ম ✓ অযাহন্টঅক্সিটিন্ট হিসাটব কাজ কটর n Sol . ES plus ✓ ✓ ✓ ✓ ✓ ✓ Each 5 ml contains, Zinc-10 mg Ascorbic acid-105 mg Each ml contains Vit E-100 mg Sodium Selenite – 0.5 mg 1 ml/L drinking water খাবার 100 ml ACI াহনটত্ ওষু প্রটয়াটগর ২৪ ঘন্টার মট য বযবিার করা উহচত্। ছিলদেশিাঃ ভয ভকান প্রাহির শম ডা ভরা কটর এবং ভয ভকান প্রাহির শটমর ভসৌন্দয বৃ ম ক্সে কটর হেোহমন ই অযাহন্ট-অক্সিটিন্ট হিটসটব কাজ কটর এবং ভকাষটক ধ্বংস িওয়া ভথটক রক্ষা কটর হেোহমন ই অযাহন্ট-বহি তত্হর কটর ভরাগ প্রহত্টরা ক্ষমত্া বাডায় হেোহমন ই ফাষ্টেমহলষ্টে সািাযয কটর এবং এর কাযকাহরত্া ম বাডায় হেোহমন ই রক্ত উৎ ািটন সিায়ত্া কটর ভসটলহনয়াম একষ্টে অ হরিায ভেস ম উ ািান যা ভকাষটক হলহ ি ার-অক্সিটিশন ভথটক রক্ষা কটর ✓ ভসটলহনয়াম ুষ্টির ভ শীবহুল হিস্ট্রহফ ভরাটগর হবরুটে কাজ কটর প্রহত্ ভকক্সজ াউিাটর কুকুটরর জনয: প্রহত্ ১০ ভকক্সজ ওজটনর Pulv. Calআটছজনয ১ ভেহবল চামচ Meat ভপ্রাষ্টেন হমল- ৬৪৪ গ্রাম হবডাটলর জনয: প্রহত্ ১-৪ ভকক্সজ ওজটনর অগাহনক ম হিহসহ - ২০০ (for the জনয ১/২ ভেহবল চামচ গ্রাম ultimate সাহিমন হফশ অটয়ল-৫ growth) গ্রাম একষ্টেে লাইে ঈস্ট১ গ্রাম েু না ভেোর- ০.৫ গ্রাম মন্টটমাহরটলানাইে হকউ. এস. েু ১০০০ গ্রাম 500 gm ছিলদেশিাঃ শরীটরর ওজন বাডাটত্ সািাযয কটর ক্ষু া বাডায়, িাড ও িাঁটত্র গঠন মজবুত্ কটর প্রহত্ষ্টে যাটকটে রটয়টছভয হরমাি াহন শরীর ভথটক ভবর িটয় যায় Pulv. PA 10 gm সম হরমাি হ এ লাইে াউিার হমহিত্ ভসাহিয়াম এহসটেে lyte হবহ - ৫.০০ গ্রাম ভসাহিয়াম ভলারাইি হবহ - ২.১৭ গ্রাম ACI Aci দ্রবি প্রাহিটক খাওয়াটত্ িটব। প্রস্তুত প্রোেী: 184 োহসয়াম ভলারাইিএকষ্টে যাটকটের সবেু কু উ ািান ২ হলোর হবশুে াহনটত্ ভমশান। ১.০০ গ্রাম সতর্েতাঃ হেোহমন এ অযাহসটেে গরম াহনটত্ সযালাইন ভমশাটবন না বা হ এইচ ভগ্রি (হেোহমন এ ভমশাটনা াহন গরম করটবন না। সযালাইন ৪০,০০০ আইইউ এর তত্হরর ১২ ঘন্টা র অবযবহৃত্ অংশ সমত্ু লয)-০.০৮ গ্রাম ভফটল হিন। ভিিটোজ অযানিাইরাস হকউ. এস. েু - ১০ গ্রাম প্রলয়াগলেত্র: ভয ভকান ভ াষা প্রাহি ও গবাহি শুর ভয ভকাটনা রটনর কল ও াত্লা ায়খানাজহনত্ কারটি াহন ও ইটলকটোলাইটের ঘােহত্ ুরটি বযবিায।ম একষ্টেে লাইে ইস্ট, খাটিয: প্রহত্ ভকক্সজ খাটিয ৪-৫ গ্রাম ৫-৭ Pulv. PA 75 gm ACI হিন খাওয়াটত্ িটব হপ্রবাটয়াষ্টেকস, Gut াহনটত্: প্রহত্ হলোর ৪-৫ গ্রাম ৫-৭ হিন ভপ্রাবাটয়াষ্টেকস, ভেষজ খাওয়াটত্ িটব। হনযাস ম এবং ভ াষা প্রািীর আকষটির ম জনয আিশ ম হমিি । তবহশিয: ভ াষা প্রািীর অটন্ত্রর বযাকটেহরয়া উন্নত্ কটর, উ কারী বযাকটেহরয়ার সংখযা বাডাটত্ সািাযয কটর এবং ভ াষা প্রািীর প্রজনন কমক্ষমত্া ম উন্নত্ কটর প্রহত্ ভকক্সজ ভত্ আটছ কুকুর ও হবডাল: ৪-৫ গ্রাম প্রহত্ ভকক্সজ Pulv. PA 100 gm ACI খাটিয সুগার- ৪৩.৫২% Horlis ফ্রুটটাজ-৪.৮৯% ভপ্রাষ্টেন-৫.৮০% ফযাে- ০.৫৬ % ফাইবার- ৫. .৬২% স্টাচম- ১৯.০১% ক্রুি অযাশ 8.৫0 % সযাকাটরামাইহসস ভসহরটেহসস ভবালািম এক্সিহ টয়ন্ট হকউ. এস েু ১০০% হনটিমশনা: ✓ ভ াষা প্রাহি ও াহখর প্রটয়াজনীয় এনাক্সজ ম প্রিান কটর ✓ ভ শী ও িাটডর গঠন মজবুত্ কটর ✓ াকস্থলীর ক্ষহত্কর জীবািু হনক্সিয় কটর প্রাহিটক ভরাগ ভথটক রক্ষা কটর ✓ ভরাগ প্রহত্টরা ক্ষমত্া বাডায় ✓ ভ াষা প্রাহি ও Tab. Vitamin Pet াহখর বাহিযক ভসৌন্দয বৃ ম ক্সে কটর Enriched with Vitamins Bcomplex & Vitamin E 1-5 kg small breeds: ½ -1 Tab 60 pcs tablet ACI 6-15 kg medium breeds: 1-2 Tab 16-30 kg large breeds: 3 Tabs More than 30 kg extra-large breeds: 4 Tablets Indications: Vitamin and Mineral supplement for healthy growth, muscle tone and shiny skin coat Tab. Multi-vitamins & Up to 5 kg of bw: ½ Tablet daily. 60 pcs tablet ACI PROMOVIT Minerals & Amino 5-10 kg of bw: 1 Tablet daily. Pet acids Over 10 kg of bw: 1 Tablet per 10 kg of body weight Indications: Daily supplement to support the immune system and keep a healthy, strong and active pet Calcium and Small puppies & kittens (Less than 60 pcs tablet ACI Tab. Calfos Phosphorus enriched 1 kg of tw): ½ Tablet Pet with Vitamins Medium puppies: (about 1-3 kg of bw): 1 Tablet Large puppies (about 3-5 kg of bw): 2 Tablets 185 Adult dog: 1 Tab per 10 kg of bw Adult cat: ½ Tablet Pregnant & Nursing bitches: 1.5 Tablets per 10 kg of bw Pregnant & Nursing queens: 1 Tablet Indications: Support for a healthy musculoskeletal system With garlic, B Directly feed to the animals. 60 pcs tablet Tab. vitamins & minerals 1 tablet daily per 10 kg of body Coatty Pet weight Indications: support for skin and coat health Non antibiotic Animal: 1 tab/2.5-3 kg BW daily 15 pcs tablet Soln. Dsolution Birds: 1 tab/250-300 ml Drinking Con water Indications: prevent diarrhea and dysentery of pet animal Each 5 ml (1 Adult dog: 3-4 teaspoonfuls daily 100 ml Liq. Pet Joy teaspoonful) Large puppies: 2-3 teaspoonfuls contains: Vitamin A, daily Vitamin C Vitamin D3, Medium puppies: 1-2 teaspoonfuls Vitamin E Vitamin B1, daily Riboflavin, Niacin, Small puppies & kittens: 1 Vitamin B6, Folic acid, teaspoonful dally, Vitamin B12: Biotin, Pantothenic Acid, or as directed by the physician Calcium, Iodine, Magnesium, Zinc, Selenium, Manganese, Chromium, Potassium, ParaAmino Benzoic Acid, Inositol, Choline. Indication: ✓ Prevents Deficiencies ✓ Boosts Energy & Concentration ✓ Helps maintain a shiny & healthy skin coat ✓ Keeps Heart Healthy ✓ Supports Eye Health ✓ For faster growth and development ✓ Maintains Muscle Strength ✓ For a shiny & healthy coat ✓ To overcome weakness and debility ACI ACI ACI Detergents, Antiseptics & Disinfectants See farm animal, medicine page- 122 186 Avian Medicine Antibiotics and Antimicrobials Amino-penicillin: Amoxicillin Indication: Gastrointestinal, respiratory & urinary tract infections like colibacillosis, salmonellosis, necrotic enteritis, infectious coryza, fowl cholera, fowl typhoid, streptococcosis, staphylococcosis etc. It is also used to prevent and treat secondary bacterial infections followed by viral infections like ranikhet, gumboro etc. Trade name Composition Trade Dose Pack size Company Pulv. Moxacil-Vet Amoxycillin Trihydrate 15-30 mg / kg b. wt. or 1 100 gm, Square : 30 gm/100 gm gm / 3-5 litre drinking 500 gm water for 5 days. Pulv. RenamoxDo Do Do Renata 30% Pulv. Moxillin Vet Do Do Do Acme DS Pulv. Acimox Do Do 100 gm, ACI 30% 500 gm, 1kg Pulv. Eskamox Do Do 100 gm, SK+F 1 kg Pulv. Augment Each gm powder 1 gm / Liter drinking 100 gm, SK+F vet contains Amoxicillin water for 3-5 days. 500 gm trihydrate BP 100 mg & Clavulanic acid BP 25 mg. Pulv. Moxilin-CV Do Do 10 g, Acme Vet 100 g 500 g Cephalosporin Cefalexin Mode of action: Cefalexin Monohydrate inhibits transpeptidase enzyme which is essential for bacterial cell wall synthesis. Bacterial cell wall becomes porous and water enters into bacteria. Therefore Bacteria swell & burst out and finally bacteria are killed. Indications: Cefalexin is indicated for poultry to prevent early chicks mortality, treatment of Coryza, Fowl Typhoid, Fowl Cholera, Bacillary White Diarrhoea, Colibacillosis, Ganggrenous Dermatitis and to combat secondary bacterial infections associated with viral diseases. Trade name Composition Trade Dose Pack size Company Pulv. CEFA-1 Each 100 g Powder For Prevention 100 gm Popular Vet contains Cefalexin To prevent early chicks Monohydrate BP mortality, give 20 g of CEFA-1 equivalent to Vet daily for 3000 Chicks. Cefalexin 7.5 g. or 1 g per 2-3 liters of drinking water for 3-5 days two times daily. For Treatment - 187 Pulv. Cromax Vet Do 20 g of CEFA-1 Vet for 1500 chicks or 250 growers or 100 layers. or 1 g per liter of drinking water for 3-5 days two times daily. Do 10 gm 100 gm Super Power Quinolones Pefloxacin Indication: Pefloxacin is indicated for the disease of poultry caused by bacteria and mycoplasma such as Salmonellosis, Colisepticemia, CRD, Infectious Coryza, Pasteurellosis, Mycoplasmosis and for secondary bacterial infection followed by viral infection such as Gumboro and Newcastle diseases. Trade name Composition Trade Dose Pack size Company Pulv. Pexacin Each 10 g powder Prevention: 1 g/2-4 liter 10 gm Opsonin contains, Pefloxacin drinking water (2.5-5 mg Mesylate Dihydrate 1 per kg body weight) for 3-5 gm days. Treatment: 1 g/liter drinking water (10 mg per kg body weight) for 3-5 days. Pulv: Peflox Do Do Do Acme vet Soln: Pexacin Each ml solution Prevention : 1 ml solution 100 ml Opsonin contains, Pefloxacin 4-8 liter of drinking water Mesilate Dihydrate BP for 3-5 days. 100 mg Treatment : 1 ml of solution 1-2 liter of drinking water for 3-5 days Soln. Pevox Vet Do Do Do Popular Enrofloxacin Indication: Enrofloxacin is used for the treatment of infections of respiratory tract, G.I tract, urinary & reproductive organs of poultry caused by gram-positive & gram-negative bacteria, Mycoplasma etc. e.g. CRD, Mycoplasmosis, Fowl cholera (Pasteurellosis), Fowl typhoid, Paratyphoid, E. coli infection (Colibacillosis), Salmonellosais, Coli septicemia, Staphylococcal & Streptococcal infection, secondary infection due to mixed bacterial & viral infection etc. Trade name Composition Trade Dose Pack size Company Sol. G-Enro Vet Each ml oral Treatment: 1 ml / 2 litre 100 ml, ACI solution contains of drinking water for 3-5 1 L bottle Enrofloxacin INN days (10 mg / kg body 100 mg. weight). Prevention: 1 ml / 4 litre of drinking water for 3-5 days (5 mg / kg body weight). Sol. Enrocin vet DO DO DO Renata DO DO Sol. Enflox-Vet Square DO DO Sol. Enrox 100 ml, Techno DO 500 ml 188 Sol. Enrovet Sol. Enroflox DO DO DO DO Sol. Enoxin vet Soln. Enroflox DS DO Each mL solution contains Enrofloxacin BP 200 mg. DO 1 mL/3-4 Liters of drinking water for 3-5 days. 100 ml 20 ml, 100 ml, 500 ml, 1L DO 100 ml, 500 ml Acme SK+F Incepta SK+F Ciprofloxacin Indication: Ciprofloxacin is effective against several diseases as C.R.D, C.C.R.D, Mycoplasmosis, Salmonelosis, Colibacillosis, Infectious Coryza, Pasteurellosis. Streptococcosis, Staphylococcosis etc. and may be used in viral disease like Gumboro, Newcastle disease etc. followed by secondary bacterial infections. Trade name Composition Trade Dose Pack size Company Sol. Ciprosol Ciprofloxacin: For prevention: 1 ml solution 100 mg/ml is to be mixed with 4-8 liter of drinking water for 3 consecutive days. 100 ml Techno For treatment: 1 ml solution is to be mixed with 1-2 liter of drinking water for 3-5 consecutive days. Sol. Ciprocin Vet DO DO Do Square Sol. Cipro-A Vet DO 100 ml, DO Acme 500 ml Sol. Ciproflox DO 100 ml, DO 500 ml, SK+F 1L Sol. Civox Vet DO DO Do Popular Sol. Beuflox vet DO DO Do Incepta n Sol . Al-Cipro DO DO DO Al-madina Soln. Proxacin 10 DO DO DO Bridge Pulv. Renaflox-20% Ciprofloxacin: 20 1 gm/2-4L of drinking water 100 gm Renata gm/100 gm for 3-5 consecutive days. Norfloxacin Indication: Colibacillosis, Infectious coryza, Fowl cholera, CRD, Respiratory tract infection (E.coli, Salmonella spp., Mycoplasma spp., Chlamydia spp. etc) & Gastrointestinal tract infection. Trade name Composition Trade Dose Pack size Company Liq. Norvet Each ml oral 1 ml/ 2 liter drinking water for 3-5 100 ml Acme solution contains days (12 mg/ kg body weight). In Norfloxacin BP salmonellosis treatment should be 100 mg. for 5-6 consecutive days. Liq. Benaflox Do For prevention: Do Bengal N 1 ml oral Liquid per 2 liters of drinking water for 3-5 days For Treatment: 1 ml oral Liquid per 1 liter of drinking water for 3-5 days 189 In case of salmonellosis the duration of the treatment may be prolonged til 5-6 days. Danofloxacin INDICATIONS is indicated for the treatment of following diseases of poultry: ✓ All kind of digestive tract infections caused by gram positive, gram negative bacteria ✓ All kind of respiratory tract infections caused by mycoplasma ✓ Secondary bacterial infections of viral diseases. Trade name Composition Trade dose Pack size Company Soln. DFN Vet Each mL contains Poultry: 1 mL / 2 Liter (5 mg / 20 ml SK+F Danofloxacin Mesylate kg body weight) water for 3-5 100 ml INN equivalent to days. 500 ml Danofloxacin 50 mg. Pigeon and Pet bird: 1 mL / Liter water for 3-5 days. Flumequine Indication: Flumequine is a quinolone derivative with bactericidal action particularly Gram negative bacteria (e.g. salmonellosis, colibacillosis as well as pasteurellosis). Mode of action: The Flumequine inhibit the bacterial enzyme DNA gyrase (topoisomerase) that is responsible for the supercoiling of DNA. The quinolones are usually bactericidal; susceptible organism lose viability within 20 minutes of exposure to optimal concentrations. Trade name Composition Trade dose Pack size Company Pulv. Renaquine Each gram 1g/L drinking water for 3-5 days. 100 gm RENATA 10% contains, Flumequine100 mg Pulv. Flumivet Do Do Do ACI Pulv. Flumil-10 Do Do 10 gm, TECHNO 100 gm Liq. RenaquineFlumequineFor Broiler 60 ml, RENETA 20% vet 200 mg per ml Under 2 weeks-0.25 ml/ L for 3-5 100 ml, days 1L Above 2 weeks-0.50 ml/L for 3-5 days For Layer & Breeders Under 6 weeks-0.25 ml/ L for 3-5 days Above 6 weeks-0.50 ml/ L for 3-5 days Sol. Flumil-20 Do Do 50 ml, TECHNO 100 ml Liq. Benaquin Vet Do Broiler: 100 ml Bengal Under 2 weeks: 1 ml/2 liter drinking water for 3-5 days Above 2 weeks: 1 ml/1 liter drinking water for 3-5 days Layer & Breeder: Under 6 weeks: 1 ml/2 liter drinking water for 3-5 days 190 Above 6 weeks: 1 ml/1 liter drinking water for 3-5 days Tetracyclines Oxytetracycline Poultry: Colibacillosis (E. coli), infectious coryza (Haemophilus gallinarum), mycoplasmosis, chronic respiratory diseases, airsacculitis, infectious synovitis (Mycoplasma gallisepticum, Mycoplasma meleagridis, Mycoplasma synoviae) clostridial dermatitis (Clostridium septicum), necrotic enteritis (Clostridium perfringens, types A & C), pullorum disease (Salmonella pullorum) fowl cholera, coccidiosis etc. Trade name Composition Trade dose Pack size Company Pulv. Otetra Each gm powder Treatment: 100 mg/kg body weight 100 gm, SQUARE Vet-50 contains or 1 gm per 2.5 litre drinking water 500 gm Oxytetracycline for 3-5 consecutive days or 50 gm Hydrochloride BP per 100 kg feed for 7 consecutive 500 mg. days. Prevention / Growth Promotion: 50 mg/kg body weight or 1 gm per 5 litre drinking water for 3-5 consecutive days or 35 gm per 100 kg feed for 7-10 consecutive days. Pulv. Oxytetracycline Do 100 gm TECHNO Technomycin 250 mg/gm Pulv. DO 50-250 gm/ton of feed, usually 3 100 gm, RENATA Renamycin dosings are required at 4-5 days 1kg interval. Pulv. DO Do 100 gm, SK+F Eskamycin 500 gm, 20% 1kg Pulv. Do Do Do ACI Bactitab Pulv. DO 1 g/ L drinking water for 3-7 days. Do ACME Tetravet Pulv. Titex Each gram 50-250 gm/ton of feed, usually 3 Do Incepta vet Powder contains dosings are required at 4-5 days Oxytetracycline interval. Hydrochloride BP 200 mg. Chlortetracycline Indication: Broad spectrum antibiotic for the prophylaxis and treatment of CRD Complex (Mycoplasmosis), Colibacillosis, Bluecomb Disease, Synovitis, Bacterial Enteritis, Fowl Cholera, Fowl Typhoid etc in poultry. Highlighting Points: (Information taken from trade manual of square) ✓ Greater therapeutic value than OTC to prevent infectious synovitis in chicken. ✓ Gives synergistic action in the treatment of CRD/CCRD in combination with low dosage of THF (Tiamulin Hydrogen Fumarate). ✓ Attain therapeutic concentration immediately after administration and ensures quicker recovery of diseases. ✓ There is no common or important side effects reported with this medicine. 191 ✓ Chlortetracycline (CTC) is one of the few antibiotics that can be used without any withdrawal period in chickens laying eggs intended for human consumption. Trade name Composition Trade dose Pack Company size Pulv. CotraEach gram water For the treatment of Mycoplasmosis: 50 gm SQUARE Vet soluble powder 110-300 mg per Kg body weight or 1500 gm contains 3 gm per litre of drinking water for 7 Chlortetracycline days or 2 gm per kg of poultry feed hydrochloride for 7 days 200 mg. For the treatment of other bacterial diseases of poultry: 125-250 mg per Kg body weight or 2.5 gm per litre drinking water for 7 days or 2-4 gm per Kg poultry feed for 5-7 days. To improve FCR, to increase weight & production of poultry: 50-100 gm per 100 Kg poultry feed regularly. Pulv. Eska Do DO 100 gm SK+F CTC 500 gm Pulv. CTC Do Do Do Opsonin 20% WSP Pulv. Captor Chlortetracycline Do 100 gm Elanco vet hydrochloride 45% (45 gm/100 gm) Pulv. CTC Vet Do Do Do Popular 45% Doxycycline Indication: is used for the treatment of all types of local and systemic infections caused by gram positive and gram negative bacteria, protozoa, rickettsia, mycoplasma of poultry and cattle. Doxycycline is indicated for the prevention and treatment of chronic respiratory diseases (CRD), Infectious Coryza, Colibacillosis, Fowl cholera, Fowl typhoid, Infectious synovitis, Mycoplasmosis, Salmonellosis, Chlamydiasis and Necrotic enteritis of poultry. Trade name Composition Trade dose Pack size Company Pulv. Doxy-A vet Each g powder To prevent early chick 10 gm, ACME contains mortality: 1 g powder per 100 gm Doxycycline USP 4 liter drinking water daily 100 mg (as for 3-7 days. doxycycline Treatment: 1 g powder hyclate). per 2 liter drinking water daily for 3-7 days. Pulv. Doxivet Do Do Do RENATA Pulv. Anti-dox Do Do 20 gm ACI 100 gm Pulv. Eskadox Do Do 100 gm, SK+F 500 gm Pulv. Doxacil vet Do Do 10 gm, SQUARE 100 gm 500 gm 192 Pulv. D-Vet Pulv. Doxipol Vet Do Do Do Do 100 gm Do NAVANA Gentry Doxycycline + Oxytetracycline Indications: Prevention and treatment of different respiratory, gastrointestinal and urogenital infections such as: CRD, Coryza, Colibacillosis and Yolk sac disease, Salmonellosis, Pasteurellosis, Clostridial infections, Air succulitis, Synovitis, Enteritis etc. Also in cases of stress due to vaccination, rehousing, transport, feed and weather changes etc. Trade name Composition Trade dose Pack size Company Pulv. OXYEach gm contains: Prevention: 1 g/4-6 Liter 100 gm Albion DOXY Doxycycline HCL-100 mg Drinking water for 3-5 Oxytetracycline HCLdays. 200 mg Treatment: 1 g/3 Liter Drinking water for 3-5 days Pulv. DO-2 Vet Do Do Do Popular Pulv. Tetradox Do Do Do Gentry (Vet) Pulv. Doxy Do Do 100 gm, Opsonin 500 gm, 1kg Doxycycline + Neomycin Indications: For treatment of mixed infections specially complicated CRD, Nonspecific diarrhoeas, Blue Comb, Mud Fever, Fowl Cholera, Coli-septicemia, Pullorum disease, infectious synovitis. Secondary bacterial infections caused by gram positive and gram negative bacteria. Trade name Composition Trade dose Pack Company size Pulv. Ndoxi vet Each gram contain Prevention: 1 g/ 10 Liter 100 gm Renata Doxycycline HCl: 150 drinking water for 3-5 days. mg Treatment: 1 g/ 5 Liter Neomycin SO4: 150 mg Drinking water for 4-5 days or till infection is eliminated. Pulv. Doxi-N Do Do 50 gm Acme vet Pulv. Neo Do Do 100 gm Gentry Doxipol (Vet) Sachet Pulv. Al-ND Each gram contain, Prevention: 1 g/ 2 Liter 100 gm AlDoxycycline HCl: 100 drinking water for 3-5 days. Madina mg Treatment: 1 g/ Liter Neomycin SO4: 100 mg Drinking water for 3-5 days. Pulv. Do 1 g per 1 – 2L of drinking 500 gm Axon Teraneocin water or 100 g per 100 kg feed for a day. Pulv. Nedo vet Each gram contain, Prevention: 1 g/ 2 Liter 100 gm ACI Doxycycline HCl: 115.4 drinking water for 3-5 days. mg Treatment: 1 g/ Liter Neomycin SO4: 100 mg Drinking water for 3-5 days. Doxycycline + Trimethoprim Indication: Salmonellosis, Colibacillosis, Mycoplasmosis, CRD, Fowl Cholera etc. 193 Trade name Composition Trade dose Pulv. Doxiprim (vet) Each gm contains – Doxycycline Hyclate 100 mg & Trimethoprim 100 mg 1 gm powder /1-2 liter of drinking water for 3-5 days. Pack size 100 gm sachet Company Gentry Aminoglycosides Gentamicin Indications: For the treatment of diseases caused by different gram positive and gram negative bacteria such as Colibacillosis, Salmonellosis, Pasteurellosis, Enteritis, Yolk sac diseases and Fowl Cholera etc. For reduction of early chicks mortality. Trade name Composition Trade Dose Pack size Company Each ml contains For IV or IM Injection Gentamicin Poultry: 0.05-0.1 ml per kg body Inj. GenacynSulphate 100 mg weight. 10 ml Square Vet This dose preferably to be given twice for 1st day and afterwards once daily for 3-5 days. Inj. Acigent DO DO Do ACI Pulv. Acigent Gentamicin 1 gm/2-4 litres of drinking water Vet 20 Sulphate-20 or 5-10 mg/kg of body weight for 100 gm ACI gm/100 gm powder 3-5 consecutive days. Pulv. Do Do Do Techno Gentamax Pulv. Do Do 5 g, Gentabac 100 g Popular Vet 20% 500 g Neomycin Description: Neomycin Sulfate is a broad-spectrum antibiotic of the aminoglycoside class. It is active against gram-positive and gram-negative bacteria like Escherichia coli, Salmonella, Campylobacter, Pasteurella (Fowl Cholera), Staphylococci and Listeria spp. Indication: effective against a wide range of diseases such as – Poultry & Pet: Bacterial Enteritis, Salmonellosis, Colibacillosis, Infectious Coryza. Trade name Composition Trade dose Pack size Company Pulv. Neoxel Each gm powder Poultry & Pet: 1 gm/ 1-3 liter of 10 gm SK+F vet contains Neomycin drinking water for 3-5 days. 100 gm, Sulphate USP 500 500 gm, mg. 1 kg Pulv. N-Cin Vet Do Do Do ACI 50 Pulv. NS-Vet Do Do 100 gm Al500 gm Medina Pulv. Neovet Each gm powder Do Do Techno contains Neomycin Sulphate USP 700 mg. Pulv. Nimocin Do 3 g/20 L (1 g/6.67 L) drinking 10 g Acme Vet water for 3-5 days. 100 g sachet. 194 Pulv. Remeneo Vet Do Poultry : 1 g per 6-7 litres of drinking water for 3 - 5 days. 100 gm 500 gm Bengal Sulfur drugs Sulphachloropyridazine + Trimethoprim Indications: is indicated for prevention and treatment of bacterial infections in poultry such as: ✓ Infectious coryza ✓ Pullorum diseases ✓ Coli-septicemia ✓ Coli-Enteritis ✓ Fowl Cholera ✓ Air sac disease ✓ CRD complex ✓ Salpingitis ✓ Omphalitis ✓ Staphylococcal infections Trade name Composition Trade Dose Pack size Company Each gram contains: 1.5-2 gm/L drinking water. Pulv. Cosumix Sulphachlorpyridazine Severe: 2.5 gm/L. 5 gm Novartis plus sodium salt-100 mg Or Trimethoprim- 20 mg In feed: 2-2.5 gm/kg feed. Pulv. Cositrim Do Do 100 gm Techno Each gm powder contains Sulphachloropyridazine Pulv. Sultrik Renata sodium USP-100 mg See below chart 100 gm Trimethoprim BP-20 mg Vitamin K3 with Sucrose excipient-880 mg Intensity of disease Sultrik per litre water Sultrik per Kg of feed Normal 1.5-2.0 gm 2.0-2.5 gm Severe 2.5 gm Control 1.0 gm Dosage schedule should be continued 3-5 days To control chick mortality during 1st week of life, Sultrik powder can be applied at the dosage rate of 1 gm per liter of drinking water for 3 consecutive days. Sulfadiazine + Trimethoprim Indications: Antibiotic against Gram-positive and Gram-negative bacteria and coccidiosis. Trade name Composition Trade Dose Pack size Company Powder Pulv. 1 g powder contains 1 gm/2 L drinking water for 7 100 gm Bremer Supermed TS-1 Sulfadiazine-400 mg days. pharma Trimethoprim-80 mg Pulv. Sulfatrim Do Do 100 gm Techno Suspension Susp. Ativet Each ml suspension This suspension should be 60 ml, Acme contains: used daily with drinking 500 ml, water. At first required dose 1L 195 Sulphadiazine BP 400 mg. Trimethoprim BP 80 mg. Susp. SulprimVet Susp. Renatrim Do should be mixed with little quantity of water which is then mixed with total quantity of water for easy dissolution. Shake the bottle before use. Treatment: 1 ml suspension with 5 litres of drinking water daily for 4-6 days. Prevention: 1 ml suspension with 10 litres of drinking water daily for 2-3 days. Do Do Do 100 ml Square 100 ml Renata Sulfamethoxazole + Trimethoprim Indication: Mycoplasmosis, Colibacillosis, Salmonellosis (Pullorum, Fowl typhoid), Fowl cholera, CRD. Trade name Composition Trade Dose Pack Company size Each 5 ml contains Poultry: Square Sulphamethoxazole Treatment: 1 ml suspension / 500 mg & 1.5 Litre of drinking water for 460 ml, Susp. Cotrim Trimethoprim 100 6 days (minimum 15 mg. per Kg 500 ml, vet mg. body weight). 1L Prevention: 1 ml suspension / 3 Litre of drinking water for 3 days. Susp. Incotim Do Do 60 ml, Incepta vet 500 ml, Susp. Cidacot Do Do 60 ml Opsonin Sulfur drugs + Erythromycin Indications: is effective against the following diseases: ✓ Infectious coryza ✓ Mycoplasmosis ✓ Coli-septicemia ✓ Pullorum diseases ✓ Enteritis ✓ Fowl typhoid ✓ Bronchopneumonia ✓ Fowl cholera ✓ CRD Trade name Composition Trade Dose Pulv. Micronid Each gm powder 0.5-1 gm/L drinking contains water for 3-5 days. Erythromycin thiocyanate INN-180 mg Sulphadiazine USP-150 mg Trimethoprim USP-30 mg Pack size 100 gm Company Renata 196 Pulv. Firmac Plus Vet Pulv. Erisen Vet Pulv. Erocot Do Do Do Incepta Do Do Do Do Square Opsonin Pulv. Eraprim Vet Pulv. EROTIN (Vet) Pulv. ETS Vet Pulv. Eryvet Do Do Do Do 100 gm 10 gm, 100 gm Do Do Do Do Do Treatment: 1 g powder per 1-2 liters of drinking water for 3-5 consecutive days. Prevention: 1 g powder per 2-4 liters of drinking water for 3-5 consecutive days. For oral administration only. For prevention- 1 g/Liter drinking water for 4-6 days. For treatment- 2 g/Liter drinking water for 4-6 days. 100 gm 100 gm Bridge ACI Pulv. Eraplus Vet Acme Albion Each gram contains 10 gm Acme Erythromycin Stearate 100 gm 25 mg, Neomycin Sulfate-35 mg, Sulphadimidine Sodium 100 mg, Trimethoprim-18 mg Bromhexine Hydrochloride-1.5 mg. Indication: Eraplus Vet is indicated for the prevention & treatment of CRD, CCRD, Bronchopneumonia, Infectious coryza, Colibacillosis, Fowl cholera, Salmonellosis, Diarrhea, Enteritis, Staphylococcal infections etc. in poultry. Macrolide antibiotic Tilmicosin Pharmacology: Tilmicosin is a semi-synthetic antibiotic of the macrolide group, and is believed to affect protein synthesis of bacteria. It has bacteriostatic action but at high concentrations it may be bactericidal. Tilmicosin antibacterial activity is predominantly against Gram-positive microorganism with activity against certain gram-negative ones and Mycoplasma of a bovine, porcine, ovine and avian origin. Indication: For the treatment and prevention of respiratory disease in chicken flocks, associated with Mycoplasma gallisepticum and M. synoviae. Precautions: Inappropriate use of the product may increase the prevalence of bacteria resistant to Tilmicosin and may decrease the effectiveness of treatment with Tilmicosin-related substances. Medicated drinking water should be prepared fresh every 24 hours. Trade name Composition Trade Dose Pack size Company Sol. Tilmibac Vet Each ml solution 3 ml/ 10 liter drinking 100 ml, Popular contains Tilmicosin water or 15-20 mg/kg 250 ml, Phosphate 250 mg. body weight for 3 days. 500 ml Sol. Tilmisin vet Do Do Do Renata n Sol . Acmetil vet Do Do Do Acme Sol. Tilcosin vet Do Do Do Square Sol. Tilvet Do Do Do Al-Madina 197 Soln. Tilmac Do Do Soln. Avitil vet Soln. Qtill-S vet Do Do Do Do 100 ml 500 ml Do 20 mL, 100 mL, 500 mL 1 L Bottle Bridge Incepta SK+F Tylosin Indication: is effective both gram positive (Staphylococcus aureus, Streptococcus, Diplococcus, Corynebacterium, Erycepolothrix, Clostridium) and gram negative bacteria (Proteus, Salmonella, Shigella, Klebsiella, Mycobacterium etc) and sinusitis, enteritis pneumonia etc. It has a particular action against Mycoplasma gallisepticum S6, which is implicated in the CRD complex in chicken & infectious sinusitis in turkeys. The use of tylosin as feed additive to promote growth is safe. Drug Interaction: Should not use with aminoglycoside antibiotic. Trade name Composition Trade Dose Pack size Company Pulv. Tam-Vet Each gm powder 2.5 gm powder/liter of 100 gm, Square contains 200 mg of drinking water or, 300500 gm Tylosin Tartrate BP. 500 gm /100kg feed for pack 3-5 days. Pulv. Tylobac Do Do Do Popular Pulv. Mycostop Do Do Do Renata Pulv. Tylosin Do Do Do Techno Pulv. Tylosef Do Do Do SK+F Pulv. Tylochem Do Do 10 gm, Chemist 100 gm Tylosin tartrate & doxycycline Indication: Gram Positive and Gram Negative Bacterial Infection, Protozoal Infection, Mycoplasmosis. Prevention and treatment of different respiratory, gastrointestinal and urogenital infections such as: Mycoplasmosis, CRD, CCRD, Coryza, Colibacillosis, Yolk sac infection, Salmonellosis, Pasteurellosis, Clostridial infections, Air sacculitis, Synovitis, Enteritis etc. Also in cases of stress due to vaccination, rehousing, transport, feed and weather changes etc. Trade name Composition Trade Dose Pack size Company Pulv. Doty vet Each gm powder Prevention: 1 g powder 100 gm Popular contains, per 2-4 liters water for 3-5 Tylosin tartrate- 200 days or 100 g powder per mg (20%) 100 Kg feed for 3-7 days. & doxycycline-100 mg Treatment: 1 g powder (10%) per 1-2 liters water for 3-5 days or 100-200 g powder per 100 Kg feed for 3-7 days. Pulv. AL-TDox Do Do Do Al-Madina Pulv. TL-Doxipol Do Do Do Gentry (Vet) Pulv. Tylorest Do 2.5 g/liter drinking water Do Incepta for 3-5 days. Pulv. Tytarvet Each gm powder Poultry and Swine: 500 100 gm Bridge contains Doxycycline gm per 1000 - 2000 liters HCl BP 250 mg and 198 Tylosin Tartrate BP 200 mg. of drinking water for 3 - 5 days. Calves, goats, and sheep: 5 gm per 50 kg body weight for 3 - 5 days. Tylvalosin Indications: Tylvalosin is indicated for the prevention & treatment of Mycoplasmosis, necrotic enteritis & cholangiohepatitis. It is also effective against diseases caused by Ornithobacterium rhinotracheale (ORT) in poultry. Trade name Composition Trade Dose Pack size Company Pulv. Tylvasin Each g contains Treatment: 1 g/5 L drinking 100 gm Acme Vet Tylvalosin (as water (25 mg/kg body Tylvalosin Tartrate weight) daily for 3 days. INN) 625 mg. Prevention: 1 g/5 L drinking water (25 mg/kg body weight) for first 3 days of life. Pulv. Valotil Do Do 10 gm SK+F vet Nitroimidazoles Metronidazole Poultry: Anaerobic bacterial infections, Histomoniasis, Trichomoniasis etc. Pigeon: Trichomoniasis (Canker). Trade name Composition Trade Dose Pack size Pulv. Dirovet Each gm contains, Poultry: 1 g/2-3 L drinking 100 gm Metronidazole BP water daily for 5 days. Sachet 300 mg Pigeon: 20 mg/kg once daily for 5 days or 50 mg/kg on alternate days for 3 treatments. Pulv. Acimetro Do Do Do vet Company Acme ACI Lincosamide Lincomycin and Neomycin Indications: is effective against a wide range of diseases of Poultry mainly caused by gram- negative & gram-positive bacteria. Such as – Necrotic enteritis, Bacterial enteritis, Respiratory tract infections, Salmonellosis, Colibacillosis. Trade name Composition Trade Dose Pack Company size Pulv. Each mL solution contains 1 mL / 2-3 liter of drinking 20 ml, SK+F Necronil vet 250 mg Lincomycin water for 3-5 days 100 ml Hydrochloride USP 250 As Body Weight: 500 ml mg and Neomycin Sulfate Neomycin (10 mg/kg 140 mg. b.w./day) Lincomycin (15-20 mg/kg b.w./day) Lincomycin and Spectinomycin 199 Indications : Chicken and Turkey: CRD (caused by E. coli); Mycoplasmosis associated or not to E. coli, Airsacculitis caused by E. coli, Avian cholera caused by Pasteurella multocida, necrotic enteritis, Non Specific Enteritis, Complicated Chronic Respiratory Disease (CCRD), Infectious Synovitis and Dermatitis. Trade name Composition Trade Dose Pack size Company Inj. Linospin Each ml injectable For IM or Subcutaneous 50 ml Bridge solution contains Injection. 100 ml Lincomycin Chicken & Turkey: 0.2 ml/kg hydrochloride USP 50 body weight once daily for 3 mg and days. Spectinomycin Sulfate USP 100 mg. Pulv. Each gm powder 15-20 mg/kg body or 1 gm/ 1100 gm Incepta Neucomycin contains, Lincomycin 2 liter drinking water for 3-5 500 gm vet Hydrochloride BP days, 1 Kg equivalent to Or Lincomycin 44 mg. 20-30 gm/100 kg feed for 3-5 days Florfenicol Indications: Colibacillosis, Salmonellosis, Fowl cholera, Fowl typhoid, Pullorum disease, Pneumonia etc. Trade name Composition Trade Dose Pack size Company n Sol . Each mL solution 1 mL / 2 L drinking water 20 ml SK+F NovoflorVET contains Florfenicol INN (20 - 30 mg / Kg body 100 ml 200 mg. weight) for 3 – 5 days. 500 ml Soln. ColiFlor Do Do Do Incepta Vet Soln. Each 1 L contains, 0.5 ml/ 1 L drinking 500 ml Axon Flopenguard Florfenicol – 200 g water for 5 days 200 N,N-dimetylacetamide – Q.S Polyethylen glycol 400 – Q.S Polysorbate 80 – Q.S Antibiotic Replacer/Antiviral Description: FRA C12 is the FRA C Lines No. 1 Product against gram positive pathogenic bacteria. This additive has proven to be up to 27 times more effective than other organic acids against gram positive pathogenic bacteria. Both field and lab trials have shown strong antiviral effects. This additive is available in liquid form, not pH dependent, odorless, heat stable up to 160 ˚ C and noncorrosive. FRA C12 is the first choice in prevention and controlling gram positive pathogenic bacteria such as Streptococcus, Staphylococcus, Enterococcus etc. It is also highly recommendable to be applied against fat enveloped viruses as ND, IB & Avian Influenza etc. Indications: ✓ Prevent and Control New Castle Disese, Infectious Bronchitis and Avian Influenza virus ✓ Prevent and Control gram positive pathogenic bacterial infections ✓ Improve feed conversion ratio & increase weight gain Trade name Composition Trade Dose Pack size Company Liq. FRA C12 Balanced mixture of Broiler : 100 ml, ACI 1-monolaurin and Prevention : 1 ml per 2-4 liters 500 ml, essential oils. water for 10-15 days. 1 Lit. 200 Control : 1 ml per 1-2 liters Water for 5-7 days. Layer : Prevention : 1 ml per 3-4 liters water for 10-15 days. Control : 1 ml per 1.5-2 liters water for 5-7 days. Pulv. Andopan Each gm powder Use in finished feed as follows 50 gm. Square contains- 10% Prevention: 2 mg/Kg body Andrographis weight or, 1 gm powder for 50 paniculata kg B.W for 5-7 days Treatment: 4 mg/ Kg body weight or, 1 gm powder for 25 kg B.W for 5-7 days Andopan Indication: is indicated for the prevention and treatment of viral diseases, act as liver tonic, immunomodulator, anti-inflammatory & growth stimulator etc. Antimycoplasmal drugs Tiamulin Hydrogen Fumerate Pharmacological properties: Tiamulin is a semi-synthetic antibiotic that belongs to the group of Pleuromutilin. The antibiotic has a bacteriostatic effect, inhibiting the synthesis of protein in sensitive microorganisms. The product is active against gram-positive and gram-negative microorganisms (Brachyspira innocens, Brachyspira pilosicoli, Leptospira spp., Clostridium perfringens, Streptococcus spp., Staphylococcus spp., Erysipelothrix rhusiopathiae, Listeria monocytogenes, Pasteurella multocida, Actinomyces pyogenes, Actinobacillus spp., Fusobacterium spp., Klebsiella pneumoniae, Haemophilus spp., Bacteroides spp., Campylobacter coli, Lawsonia intracellular is), as well as chlamydia and mycoplasmas (Mycoplasma hyopneumoniae, Mycoplasma hyosynoviae, M. hyorhinis, M. bovis, and others). Tiamulin accumulates in eggs of turkeys in the same way as in eggs of chickens. Indications for use: is widely used for prevention and treatment of disease of the respiratory tract caused by mycoplasmas and complicated by secondary bacterial infections in commercial broiler, layer and breeder. Synergism: Show Synergistic action with tetracycline group antibiotics. Contra-indications: The coccidiostats viz. Monensin, Narasin, Maduramycin and Salinomycin should not be administered together with therapeutic level of Tiamulin as they show dose related incompatibility. All other coccidiostats and chemotherapeutics may be used simultaneously. Trade name Composition Trade Dose Pack Company size Pulv. Denagard 45% Tiamulin For treatment: Hydrogen In water: 25-30 mg/kg body Fumerate-450 weight or 1 gm/2 Liter water for mg/gm 3-5 days. In feed: 30-40 gm/100 kg feed 20 gm, for 5-7 days. Novartis 100 gm For prevention: sachet. In water: 12.5-15 mg/kg body weight or 1 gm/4 Liter water for 3-7 days In feed: 15-20 gm/100 kg feed for 3-5 days. Pulv. Renagard 45% DO DO 100 gm Renata 201 (for more details, see leaflet) Pulv. Tiamul 45% DO Pulv. Megagard 45% Pulv. Tiavet vet DO DO DO Pulv. Stiagen-Vet DO DO Pulv. Benagard Vet Pulv. Mycogard vet Pulv. Maxgard Vet Do Do Do Do Do Do DO Do 10 gm, 100 gm 10 gm 20 gm, 100 gm 20 g 50 g 100 gm 100 gm Do Techno Popular Incepta Square Bengal ACI Gentry Tilmicosin (See previous Macrolide antibiotic, page-197) Tylosin tartrate (See previous Macrolide antibiotic, page-198) Tylosin Tartrate + Doxycycline (See previous Macrolide antibiotic, page- 198) Tylvalosin (See previous Macrolide antibiotic, page- 199) Anticoccidial drugs Natural Coccidiostat Trade name Pulv. Herb-Al COCC-X Composition Natural compound Trade Dose Pack size Company Poultry: 0.3-0.5 kg/MT of 20 kg Bag Square feed regularly and Dairy cows: 30-40 g per 500g day for 2-3 weeks container Calves: 10 g per day for 3-4 weeks Sheep/Goats: 2-4 g per head and day for 2-3 weeks Indication: Effective against protozoan infection like coccidiosis and cryptosporidiosis, Prevents the infection of Heterakis gallinarum, Histomonas meleagridis (Histomoniasis), Improves gut health, Enhances innate immunity, Reduces wet litter issues, Improves feed conversion ratio (FCR) Sulfaclozine Na Mode of Action: Sulfaclozine Na is an antibiotic belonging to the group of sulfonamides. Like all sulfonamide, sulfaclozine is a competitive antagonist of para amino benzoic acid (PABA), a precursor of folic acid, in protozoa and bacteria. Folic acid is a coenzyme necessary for the synthesis of nucleic acid, hence sensitive species do not multiply in presence of Sulfaclozine Na. Indications: is used for the control and treatment of all types of Coccidiosis, Fowl Cholera & Fowl Typhoid in poultry. Trade name Composition Trade Dose Pack size Company Sulphaclozine Sodium Treatment 10 gm, Pulv. ESB3 30% Monohydrate: Broiler/Layer: 1.5 g – 2.0 Novartis 100 gm 300 mg/ gm g/liter of drinking water for 202 DO Pulv. SCZ WSP Pulv. Clozivet Pulv. Coccino 30 % Pulv. Coxicure 30% DO Sulphaclozine Sodium 300 mg/ gm with Vitamin K3 enriched Each gm containsSulphaclozine sodium monohydrate- 300 mg/gm Sucrose- 700 mg 3-5 consecutive days for any age. In severe case, 2.5 g/liter of drinking water or 2.0 g to 2.5 g kg feed. Control Broiler: 1 g/L of drinking water at 3 rd weeks of age for 1st time & 5th weeks of age for 2nd time. Each time the duration will be 3 consecutive days. Layer: 1 g/L of drinking water at 3rd weeks of age for 1 st time, 5th weeks of age for 2nd time and at the start of laying for 3rd time. Each time the duration will be 3 consecutive days. DO DO Prevention : 1 gm / liter of drinking water Treatment : 1.5- 2.5 gm / liter of drinking water Same as ESB3 30% 10 gm, 100 gm 100 gm Acme Opsonin 100 gm 500 gm SK+F 100 gm Renata Amprolium HCl & combined with others Indication: For prevention and treatment of acute and chronic coccidiosis of poultry. Trade name Composition Trade Dose Pack size Each mL solution contains 1 mL/1-2L drinking water, 20 ml Soln. Amprolium Hydrochloride for 5-7 days 100 ml Amprol L 200 mg. 500 ml Each 1 gm powder contains Prevention: 1.5 gm/5 L Pulv. Amprolium HCl-200 mg drinking water for 5-7 days. 100 gm Coccinil-20 Treatment: 2 gm/L drinking water for 5-7 days. Pulv. Do Do Do Amprol Vet Each 100 gm contains 20 gm, Pulv. Prevention: 1 gm/2 L Amprolium: 17 gm, 100 gm, Amprolin drinking water for 7 days. Sulfaquinoxaline: 17 gm 500 gm Plus Treatment: 1 gm/L drinking Vitamin K: 0.1 gm water for 5-7 days. Pulv. Remecox Vet Do 1 gm / 1 Litre of drinking water or 1 gm / 3 kg feed for 5-7 days. 100 gm, 500 gm Company SK+F Techno SK+F Techno Bengal 203 Pulv. Cocci Off Pulv. Coctreat-EP Pulv. CocciK Each 100 g powder contains Amprolium-10.2 g Sulfaquinoxaline Sodium10.2 g Menadione Sodium Bisulfite-0.1 gm (Vitamin K3) Each gm contains, Amprolium: 100 mg, Sulfaquinoxaline: 60 mg, Ethopabate: 5 mg Vit k3: 2 mg, Vit C: 20 mg Each 100 g powder contains, Sulphadimethoxine BP 2.00 gm Sulphadimidine BP 20.00 gm Diaverdine BP 3.00 gm Nicotinamide BP 3.00 gm Vitamin k3 Ph Grade 2.00 gm 100 gm Acme 100 gm Square Do Prevention: 1 gm/4 L drinking water for 5-7 days. Treatment: 1 gm/ 2 L drinking water for 5-7 days. Treatment: 1 gm powder per 1 litre of drinking water for 3 days. Prevention: 1 gm powder per 2 litres of drinking water for 3 days. 20 gm, 100 gm, 500 gm ACI Toltrazuril Pharmacology: Toltrazuril acts both on the schizogony and the gametogony stages of the parasites. Giving treatment by Toltrazuril after the coccidia infection the light and electron microscopic studies showed that all intracellular development stages of Eimeria are damaged. The changes occur only in the parasites and do not affect the tissue cells of the host animals. These findings suggest that toltrazuril interferes with the division of the nucleus and with the activity of the mitochondria, which are responsible for the respiratory metabolism of the parasites. In all intracellular development stages a severe vacuolization due to inflation of the endoplasmatic reticulum occurs. In the macrogametes it damages the so-called wall-forming bodies II. Toltrazuril thus has coccidicidal rather than coccidiostatic action. Highlighting Points: Broad spectrum anticoccidial activity. ✓ It destroys all intracellular stages of Eimeria species. ✓ No interfere with the development of natural immunity. ✓ Compatible with all feed additives & feed medicaments. ✓ No adverse influence on water & feed intake. ✓ No negative effect on weight development & feed conversion. Indication: Treatment of coccidiosis in Chickens and turkeys. Chickens: E. tenella, E. necatrix, E. acervulina, E. maxima, E. brunette & E. mitis. Turkeys: E. adenoides, E. meleagrimitis, E. maleagridis & E. gallopavonis. Trade name Composition Trade Dose Pack Company size Each ml liquid Treatment: 7 mg / kg body weight contains Toltrazuril per day for 2 consecutive days or 1 INN 25 mg. ml / liter of drinking water for 2 Liq. Coxitril consecutive days or 28 ml/100 kg 100 ml Square vet flocks for 2 consecutive days; 24 hours continuously or 8 hours each days in drinking water. 204 Soln. Tolicox Do Soln. Toltacox Vet Do Soln. Anticoc Soln. Xmeria Soln. Renazuril Liq. CocciTol Plus Do Do Do Each 100 ml contains, Toltrazuril 2.5 g, Polyethylene glycol 400-47.3 g, Triethanolamine 47.3 g, Sodium formaldehyde sulfoxylate-0.3 g, Urea 0.5 gm & Carrier q.s. to 100 ml. For severe infections, the treatment may be repeated 5 days later. Prevention: 7 mg /kg body weight for 2 consecutive days within 10-18 days per month up to 4 months of age as a strategic administration program. DO Oral administration only. Poultry Prevention: 1 ml/L drinking water for three medications on 9-10, 16-17 & 23-24 days of life. Treatment: 1 ml/L drinking water for 48 hours continuous administration, or 3 ml/L of drinking water for 8 hours per day for 2 consecutive days. Or, 7 mg/kg per day for 2 consecutive days. Medicated drinking water should be used within 24 hours. Do Do Do 1 ml per litre of drinking water for 2 days continuous medication or 3 ml per litre of drinking water for 8 hours per day, on 2 consecutive days. This corresponds to a dose rate of 7 mg Toltrazuril per kg body weight or 28 ml Cocci-Tol Plus per 100 kg body weight per day for 2 consecutive days in drinking water. Do Popular 100 ml, 500 ml Incepta Do 100 ml Acme SK+F Do Renata Do ACI Anthelmintics Piperazine citrate Pharmacology: When exposed to Piperazine, worms suffer from hyperpolarization of their muscles which produces a reversible paralysis that prevents them from maintaining their position in the host’s gut, and they are voided with the feces. Indication: Piperazine is used for the treatment of infestation caused by round worm such as Ascaridia galli, Heterakis gallinarum, Syngamus trachea etc. Trade name Composition Trade Dose Pack size Company Each 10 g contains 250 mg/kg body weight or use 100 gm, Pulv. Piper vet Piperazine Citrate USP according to the following Square 500 gm 10 g dosage schedule: 205 Pulv. Razinmax Vet Pulv. Peravet Do 10 gm powder in 6 8 litre of drinking Or 3.5 kg feed for 100 chicken (46 weeks) or 50-60 pullet or 20-30 layers Do Do Do Pulv. Renaper Do Do Pulv. Vetapar Pulv. Eskapar 100 Do Do Do Incepta Acme Renata Do 100 gm 10 gm, 100 gm 100 gm Do Do Navana SK+F Albendazole Uses/Indications: broad-spectrum dewormer. Indication: acts against the following parasites: Nematode- Ascaridia galli, Syngamus trachea, Heterakis gallinarum, Capillaria spp, Oxyspirura mansoni Cestode- Raillietina spp. , Davainea spp. Pack Trade name Composition Trade Dose Company size Susp: Each mL solution Round worm: 1 ml /10 kg body 20 ml, SK+F Alben Vet contains weight 100 ml Albendazole BP (as 10 mg / kg BW) 500 ml 100 mg Tape worm: 1 ml / 5 kg body weight bottle (as 20 mg / kg) Fenbendazole Indication on Poultry: Fenbendazole is used for the treatment of infestation caused by round worm such as Ascaridia galli, Heterakis gallinarum, Syngamus trachea etc. Trade name Composition Trade Dose Pack size Company Liq. Fenazol vet Each ml contains 0.1 – 0.5 ml /kg body weight 100 ml, ACME Fenbendazole BP (20-100 mg/kg) as a single dose 500 ml 200 mg. or 1 ml/200 kg body weight (1 mg/kg) daily for 5 days. Levamisole Pharmacology: Levamisole HCl acts by interfering carbohydrate metabolism of nematodes by inhibiting the production of succinate dehydrogenase. Inhibition of this enzyme causes complete and irreversible muscular paralysis of worm. Recently Levamisole hydrochloride draws much attention for its immune modulator properties. This drug corrects immunologic imbalance by modifying activities of T lymphocytes and phagocytes and thus it has the greatest benefit in the immunologically depressed animals as well as birds. The tissue concentration of levamisole persists for 5 days. Indication: Levamisole is used for the eradication of nematodes of alimentary tract eg. (Ascaridia galli, Heterakis gallinarum, Capillaria obsignata) and respiratory tract (eg. Syngamus trachea. It can also be used with water to eliminate fowl eye worm (eg. Oxuspirura mansooni) Pack Trade name Composition Trade Dose Company size Pulv. Elcaris Each gm contains 80 mg per Kg body wt. 20 gm, vet Levamisole HCL Square 100 gm BP 300 mg 206 equivalent to 254.2 mg. Pulv. Poulnex Pulv. Mitrax Pulv. Avinex Do Do Do Pulv. Neotrax vet Do + Sucrose BP 700 mg. The following dosage schedule can be followed for effective deworming- 1 gm mixed with 1 litre of drinking water can be used for 07 layer birds or 10 pullets or for 20 birds of grower stage (4-6 weeks age). Single application can ensure total elimination of worms. All other sources of drinking water should be removed during treatment with medicated solution. Do Do Do Do 100 gm Do 10 gm, 100 gm Novartis Incepta 100 gm Acme Renata Ivermectin Indications: Internal Parasitism: For the treatment of Infestation caused by roundworms. External Parasitism: For the treatment and control of infestations caused by ticks, mites, fleas and lice. Trade name Composition Trade Dose Pack size Company Internal parasitism: 1 ml for each 25 kg of body weight. (0.4 Each ml solution mg per kg of body weight). If 100 ml, contains Sol. Acimec 1% necessary repeat in 15 days. 500 ml, ACI Ivermectin BP 10 External parasitism: 1 ml for 1L mg. each 25 kg of body weight during two consecutive days. Do Do 15 mL, n Sol . Verkil vet 100 mL & SK+F 500 mL Poultry: Apply 5 drops/kg body 15 ml Soln. A-mectin Each ml contains weight topically & repeat the dropper ACME vet Ivermectin: 5 mg same dosage in 14 day bottle Fly controllers ✓ Fecal maggot control in poultry. ✓ Cyromazine is also used as a spray onto surface of manure. ✓ It is an insect growth regulator feed premix for the control of fly larvae in poultry manure. Trade Composition (Per Trade Dose Pack size Company name kg) Pulv. Cyromazine: 10 gm Mix 500 gm/ton feed. 2 kg Novartis Larvadex Start treatment when flies become active and continue treatment for 4-6 weeks or until fly population is under control. Then discontinue and repeat the treatment when flies re-establish themselves. The use an adulticide is 207 Pulv. Larvozin Do recommended after each treatment, in order to control the influx of adult flies. It is very important to establish Do Pulv. Larvakill Do Do 500 gm, 1 kg, 10 kg 20 kg Square Eon Metrifonate Indication: Biting and sucking lice, mange mites, fleas, flies, red avian mites (Dermanyssus avium, Dermanyssus gallinae), scaly leg mites (Cnemidocoptes mutans), skin larvae of Hypoderma bovis, Hypoderma lineatum, Dermatobia hominis, stomach bots (Gasterophilus spp.), tick and roundworms (Hump sore). Pulv. Each gram powder Poultry: Carefully spray or dip the 10 gm SQUARE Ectonil contains fowl for 1-2 minutes. Spray also floors, sachet Vet Metrifonate USP walls, ceiling, nests, windows, doors (Trichlorfon) 1.00 and the other sites where the gm. parasites or flies gather. Concentration: 1.5 gm per liter of water. Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Indication: is indicated for antipyretic, analgesic and anti-inammatory effect on Poultry. Pain, Fever (Vaccination), debacking, injury etc. associated related pain. Trade Name Composition Trade dose Pack size Company Pulv. FASTEach g contains 1 g/2-3 L drinking water 2-3 100 gm Acme VET Paracetamol BP 500 mg. times daily for 2-3 days. 500 gm Pulv. Carbasalate Calcium BP Poultry : 0.5 gm per liter of 10 gm Renata Renaspirin 76.32 gm (Equivalent to drinking water for 2-3 60 g of Acetylsalicylic consecutive days. acid) and Sodium Ascorbate USP 7.48 gm (Equivalent to 6.65g of Ascorbic acid) Pulv. Bcox-Vet Do Do Do Square Respiratory stimulants Indication: In poultry, during respiratory distress as in chronic respiratory disease (CRD), coryza and respiratory disease complex (RDC). Trade Name Composition Trade dose Pack size Company Liq. Respiron Respiron contains Treatment: 1 ml per liter of 100 ml, Square alkalizers, urinary water for 4 days with 1L acidifiers, buffers and prescribed antibiotic. aminonitrogen. Continue for 3 days after withdrawing antibiotic for better result. Prevention: 0.5 to 1 ml per liter of water for 3-5 days. Liq. Each 100 ml contains Treatment: In general 1 100 ml, Acme Bronchovet Adhatoda vasica -16 g, ml/liter of drinking water or 500 ml, For 100 birds 208 Soln. DILORES VET Soln. Respiton Soln. Respocare Pulv. Mucospel-Vet Pulv. A-COLD VET Zingiber officinale- 400 mg, Glycyrrhiza glabra- 500 mg, Ocimum sanctum-2 g, Vitamin E-50 mg, Vitamin B5-52 mg & sodium chloride-750 mg. Each 100 ml contains Eucalyptus oil 20 ml, Mint oil 20 ml, Thyme oil 20 ml, Menthol 10 ml, Camphor 2 ml, Ocimum sanctum 12 ml & Sorbitol 16 ml. Mint oil- 2% Juniper oil- 2% Rosemary oil- 2% Oregano Vulgare oil- 2% Surfactants & stabilizers- 15% Distilled water- 77% Eucalyptus oil, mint oil, l-manthol, thyme oil, oregano oil , trachyspermum ammi, turmeric curcuma, eucalyptus globules , allium sativum, 209hermo piperita Each gram powder contains Bromhexine Hydrochloride BP 10 mg. Do Chicks- 2 ml/day for 7 days. Grower- 5 ml/day for 7 days. Layer/Broiler Finisher-7 ml/day for 7 days. Prevention- 3 days/week mixing in morning drinking water. 1L bottle. For use in animal/ poultry feed. 1 ml/4-5 L Drinking Water for 2-4 days. In chronic case: 1 ml/2 L Drinking Water. Spray: Mix 1 ml/ L water and spray. For Spray (General protection purpose): 3 ml /1 liter of water. For oral administration Breeder/Broiler/Layer/Sonali: 0-14 days; 60 ml/day/1000 Chicken 14-28 days; 100 ml/day/ 1000 Chicken Above 28 days; 150 ml/day/1000 Chicken Or, 1 ml/3-5 Liter of drinking water till the symptoms disappear. General: 1 ml/10 L water Chick: 5 ml/50 L water/1000 chicks. Broiler, layer, breeder 10 ml/50 L water (3-5 days) 100 ml 500 ml bottle. Acme 100 ml Popular 100 ml, 250 ml Renata 10 gm 20 gm 50 gm 100 gm 500 gm Square 100 gm Acme For oral administration in the feed or drinking water. Poultry: Each gm powder per 3 litre of drinking water (0.5 mg/kg body weight) for 5 days. Poultry: 1 g/ 4-5 liters of drinking water once daily for 5-7 days. Add to feed or drinking water immediately before administration. 209 Diuretics Uses: ✓ To improve the renal system functioning. ✓ In the management of Gout and Ascites. ✓ To protect kidney from pathogens How works: Nephromodulator substances improve the physiological functioning capacity of the renal system while also rejuvenating the kidneys. Sodium Fluoride is a known kidney stimulant. Butyric acid can reduce the chances of kidney damage by pathogens. The role of aminonitrogen is to stimulate type IV hypersensitive reaction in system and to overcome stress and to have increased CMI, hence increased resistance and less damage to kidneys. Potassium Chloride and Citric Acid acts as buffer which not only helps in maintaining pH but also act as source of diuretics to enhance urine output. Trade name Composition Trade Dose Pack Company size Each 1 Litre contains – Sodium fluoride– 8.0 mg 1-2 ml per liter of Butyric acid– 15.0 mg drinking water: 100 ml, Liq. Nephrocare Amino nitrogen– 105.0 mg Square Administer for 5-7 500 ml Nephromodulators – 32.0 mg days Potassium chloride & Citric acid (as fortified base)– 35 gm Liq. Nephroflush Do Do Do ACI Each 100 ml solution contains Sodium Fluoride 1.0 mg Butyric Acid 2.0 g Soln. Renal Vet Do DO Popular Amino Nitrogen 11.0 mg Nephromodulators 4.0 mg Citric Acid 1.6 g Each 100 ml contains Halite 3 g, 1 ml/ 1-2 Liter of Salmiac 10 g, Soln. Neftonic vet drinking water for 100 ml Acme Glucitol 25 g, 3-5 days. Citrosodine 3 g Alpha Propylene 10 g. Bol. Edecure vet Each bolus contains Poultry: 0.5-1 5x4 Boli Acme Furosemide BP 2 g. mg/kg body in weight. blister The bolus may be strip. administered through mixing with required amount of feed/water by grinding the bolus. Vit B1, B2, K3, Nicotinamide, Care & Pulv. Nephroliv NaCl, KCl, Methionine, Lysin, 1 gm/L drinking 100 gm cure care Nuxvomica, Cardamon, water Agrovet Methica, Cenamon 210 Pulv. Nefguard Vet Each gram contains For oral 100 g Acme Methenamine-950 mg, administration Sachet (Nephromodulator) Thiamine hydrochloride (B1) 8 only. mg, Riboflavin BP (B2)- 1 mg Poultry- 1 g/Liter Menadione sodium bisulfate drinking water for (K3)- 2 mg. 3-5 days. Indication of Nefguard Vet-is indicated in cases of urinary tract infections (such as- nephritis, cystitis etc.) and effective as a preventive in cases of ascites, gout, pharmacological poisoning, gumboro etc.in poultry. Anti Gout preparation Trade name Composition Trade Dose Pulv. Alurol Vet Each gm powder contains Allopurinol USP 50 mg 25 mg/kg body or 2.5 gm/liter water for 3-5 days, Pack size 100 gm 500 gm Company Incepta Salmonella and other organism killer/ Ammonia controller ✓ Destroys more than 99% Salmonella & other pathogenic bacteria within 48 hours. ✓ Helps to increase egg production & growth rate. ✓ Helps to promote immunity. ✓ Helps to protect pellet feed from salmonella. ✓ Prevents pullorum, fowl typhoid & paratyphoid of poultry. ✓ Promotes enzymatic activity in the body & increases ✓ FCR. Trade name Composition Trade Dose Pack Company size Propionic acid: Pulv. 1-2 kg/ metric ton of feed. Calcium propione: 25 kg Square Hamecosal R Or Formic acid: Dry 100-250 gm/100 kg feed, Sorbic acid: continue. SiO2: Pulv. SalmoFormic acid (85%):30%, 25 kg Novartis nil Dry Acetic acid: 21%, 300 gm/ 100 kg feed Propionic acid: 8%, Citric acid: 13%, Calcium: 21%, SiO2: 7% Ca Propionate: 60%, Propionic acid: 12%, 25 kg Square Pulv. Nosal 0.5-1 kg/ metric ton feed Formic acid: 2%, Sorbic acid: 1%, Career: 25% Organic acid + Pulv. Salt 1 – 4 kg/t feed Renata Biotronic-SE + Acidifier Saponin, Glycol 100 gm/ton feed. Pulv. Gas Free If ammonia level, above 25 10 gm Renata PPM: 200 gm/ton of feed. Liq. Ammogut Each ml contains 1 ml/10-11 liter drinking 100 ml Acme Vet water. 211 Yucca extract 65 mg, Formic acid 85 mg, Propionic acid 150 mg, Phosphoric acid 150 mg, Monopropylene glycol 5 mg Sorbitol 3.5 mg. Acidifiers A liquid acidifier for poultry drinking water based on a synergistic combination of organic acids, inorganic acid, trace element copper, and bioflavonoids. The acids lower the pH and thereby improve the digestion of nutrients and inhibit the growth of pathogenic bacteria (like E. coli, Salmonella spp., Clostridium sp., & Staphylococcus sp), moulds , and yeast. Indication: To maintain balance between helpful & harmful bacteria in intestine of animal & birds; non-specific diarrhea; in stress condition (which causes – recurrent diarrhoea, mortality, decrease production, increases the virulency of diseases, hampers to develop immunity in the body after vaccination). Trade name Composition Trade Dose Pack Company size Well balanced mixture of Preventive: 0.5-1 ml per litre Monoglycerides of of drinking water. Propionic acid Treatment: 1-2 ml per litre of 100 ml (Monopropionin), drinking water. 500 ml ACI Liq. Fra AC 34 Monoglycerides of Butyric Through Feed: 900-1850 ml 1 Lit acid (Monobutyrin) and per ton of feed in broiler and Encapsulated essential 600-1850 ml per ton of feed in oils. layer. Organil pH each ml contains: Citric Acid (91%) : 160 mg Formic Acid (99%): 15 mg 100 ml Liq. Organil 1 ml in 4-5 Liter of drinking Lactic Acid (97%) : 60 mg 500 ml Popular pH water. Propionic Acid (96%): 160 bottle. mg Sorbic Acid (90%) : 40 mg Neem Leaf Extract : 4% Yeast-extract-2% Per Litre of drinking waterLactic Acid-2% L-ascorbic Acid-1% Propionic Acid-7% Citric Acid-2% 100 Sorbic Acid-2.5% ml, Liq. Hameco Ammonium Propionate 500 Square pH 7% ml, Use 5-7 days for treatment, Ammonium Formate-24% 1 Litre. may be use few weeks if Formic Acid-15% necessary. And for prevention Acetic Acid-14% of diseases one time (6-8 Propylene Glycol-5% hours) daily for 5-7 days. Water-18.5% Formic Acid, Propionic 0.5–2.0 litre/1000 litre of Liq. Biotronic 100 Acid, Lactic Acid drinking water. Renata SE Forte ml, 1L 1.0–3.0 litre/t finished feed. 212 Soln. ACIDIFIER Vet Soln. Selko-pH vet Soln. Avian pH Lactic acid 15%, Citric Acid 15%, Formic Acid 10%, Phosphoric Acid 2%, Acetic Acid 5%, Tartaric Acid 15%, Propionic Acid 10% & Excipients Q.S. up to 100% Acetic acid, Formic Acid, Ammonium Formate and Copper. Lactic acid, Propionic acid, Formic acid, HMTBa (Methionine Hydroxy Analogue) Add 1 ml per 1 liter of drinking water. 100 ml, 500 ml, 1 Litre. Acme 1-2 ml/liter drinking water for 3-7 Days. Do Incepta 20 ml 100 ml 1L Sk+f Toxin neutralizers Indication: Overcome mycotoxicosis, reduces the negative effect of mycotoxins, improves response to vaccination, improves animal immune system, better functioning of body organs especially liver kidney and ovaries and improves amino acid absorption. Trade name Composition Trade Dose Pack size Company Liq. Toxinil-Plus Cytric acid: 8%, 0.5-2 ml/L for 3-5 1L Novartis Phosphoric acid: 6%, days Lactic acid: 2%, Formic acid: 0.2%, Propylin Glycol: 10%, Yeast Extract: 5% Liq. Two-Plus Each litre contains 1 ml/2-4 liter of 100 ml, Square Yeast extracts- 0.30 gm drinking water for 500 ml, Citric acid – 8.00 gm 3-5 days. 1 litre. Tartaric acid- 1.50 gm Na K tartrate- 0.10 gm Thiamin Mononitrate- 0.30 gm Cu Penta-sulphate- 10.00 gm Propylene glycol- 100.00 gm Sacharomyces cerevisae- 20.00 gm Phosphoric acid – 6.50 gm Malic acid- 1.00 gm Riboflavin – 0.30 gm Na citrate- 0.10 gm Pyridoxine HCl – 2.00 gm Di-sodium EDTA – 1.50 gm Aspartic acid- 0.20 gm Distilled water- q.s. to make 1 litre Liq. AquaTox Vet Toxin Binder with a unique 1 ml/1-2 liter Do Incepta combination drinking water for (Organic acids, Probiotics, 3-5 Days Vitamins, Minerals & Salts) 213 Soln. Auritox-Plus Vet Each 100 ml contains Beta glucan 17.5 mg, Mannan Oligosaccharide-22.5 mg, Yeast extract-30 mg, Citric Acid-800 mg, Phosphoric Acid-650 mg, Malic Acid-100 mg, Tartaric Acid-150 mg, Aspartic Acid-20 mg, Saccharomyces Cerevisiae-2 gm, Sodium Citrate-10 mg, Sodium Potassium Tartrate-10 mg, Thiamine Mononitrate-30 mg, Riboflavin-30 mg, Pyridoxine Hydrochloride-200 mg, Copper Pentasulphate-1 gm, Propylene Glycol-10 gm, Disodium EDTA-150 mg. Shake well before each use Do Acme 0.25-0.5 ml/L drinking water daily for 3-5 days. During Stress: 0.5-1.0 ml/L drinking water daily for 3-5 days. Toxin binder + Mold inhibitor Uses: • Acts as a Toxin binder and destroy Mycotoxin from poultry feed. • Acts as a broad spectrum Mould inhibitor & destroy fungus from poultry feed. • It prevents bio-synthesis of mycotoxin in feed. • It causes bio-nutralization of Mycotoxin when feed contain Mycotoxin. • It enhances growth rate of poultry. • It increases egg production in layer. • Absorb moisture from feed & keep feed in dry condition. • It promotes enzymatic activity & liver function for detoxification. Trade name Composition Trade Dose Pack Company size Pulv. Propionic acid, Calcium 100-200 gm / 100 kg feed 25 kg Square HamecoMoltoxpropionet, Fumeric acid, continue. Dry Sorbic acid, and as active Or career Hydrated Magnesium 250 gm / 100 kg feed Aluminosilicate. when feed is affected severely with Fungus, Mould & Mycotoxin. Pulv. Moltox A perfect blend of Organic acids- 15% Natural Herbal ingredients & Live Yeast Culture- 5% Activated Charcoal- 5% Zeolites (HSCAS) – 75% Stabilizers. To get better result keep the mixture feed 24 – 48 hours before feeding. 1 kg per Ton of finished feed. 25 kg Square 214 Pulv. Mycofix Plus Pulv. MycofixSelect SBM+Epoxidase+Esterase Phytogenic+Phycophytic SBM, Epoxidase, Phytogenic, Phycophytic Pulv. Check-OTox Bioplus Per kg contains, Hydrated sodium calcium 215hermos silicate-861 g, mannan oligosaccharide-50 g, oxine copper-1 g, propionic acid-50 g, benzoic acid-15 g, acetic acid-15 g, sorbic acid-8 g Each Kg powder containsPropionic Acid (E-280)162.000 mg Ammonium Propionate (E284)- 25.000 mg Anti-caking agentsColoidal silica (E-551b)10.000 mg Sepiolite (E-562)- 790.000 mg Each 100 ml contains Yeast of saccharomyces cerevisiae (𝛃-glucan and Mannan oligosaccharide)7000 mg Citric Acid-4000 mg Ortho-Phosphoric Acid-7000 mg , Malic Acid-1000 mg Copper penta sulphate-1000 mg, Formic Acid-7000 mg Lactic Acid-1000 mg Sorbic Acid- 100 mg Fumaric Acid-2000 mg Essential oil (Thymol) - 100 mg, Emulsifiers-5000 mg Pulv. CIDOFUNG Soln. Six Plus (Six Plus™ has Triple benefits – act as Toxin Binder, Acidifier & Growth Promoter.) Preventive dose: 0.5 to 1 kg per ton of feed. Poultry layers: 1.5 – 2.5 kg/mt of finished feed * Chicks in the starter phase: 1.5 – 2.5 kg/mt of finished feed * Finishing Animals: 1.5 kg /mt of finished feed * In case of low contamination: 0.5-1 kg / mt of finished feed as a preventive dose * depending on the contamination level. Poultry – feeds containing up to 12% moisture level: 500 g/ton of feeds; 1 kg, 25 kg 1 kg, 25 kg Renata 25 kg Navana 500 g -2 Kg/ Ton. Of raw materials or final feeds 25 kg SK+F 1 ml / 2.5-5 L of drinking water 100 ml 500 ml SK+F Renata feeds containing 12-18% moisture level: 1 kg/ton of feeds. 215 Liq. Protox Propylene glycol 10.00% Yeast extract (Protein 2.5% Polypeptide 0.6%, Amino acid 0.8%, Flavor nucleotide 1%, microelement 0.1%)5.00% Citric acid-8.00% Orthophosphoric acid-6.00% Lactic acid-5.00% Vitamin-mineral (Vitamin C 2%, Vitamin E 0.9%, DL-Methionine 1.3%, Magnesium sulphate 0.8%)- 5.00% Phytogenic extracts (Betaine 15%, Mannitol 6%, and D-Sorbitol 4%)- 25.00% Carrier Q.S 1 ml in 1 Liter of drinking water. 100 ml, 500 ml 1 Liter bottle Popular Antioxidants Pharmacology: Hadox-Dry® is free flowing powder to stabilize any chemical or biological system susceptible to auto-oxidation. Hadox-Dry® contains a strong synergistic mixture of registered ingredients. Metal ions, which start up autooxidation, are eliminated by chelation. Emulsifiers (Mono and diglycerides of edible fatty acids) ensure homogenous distribution of the active ingredients. Owing to the unique Hadox-Dry® coating process, the contact surface with the active antioxidant ingredients is maximized. PH of 5% sample is 5.4-6.4.It is thermo stable. Indication: To prevent oxidation of the compound feed. Trade name Composition Trade Dose Pack Company size B.H.A 2% In compound feed: 125 Phosphoric acid 2% gm per ton of feed. Ethoxyquin 2% 10 kg Pulv. HadoxIn premix: use the Mono and diglycerides of bag Square Dry required quantity to give edible fatty acids 2% 125 gm per ton in the Citric acid 2.5% final feed. Carrier (Silica+CaCO3) 89.5% Immune stimulators Indication: • To stimulate Cell Mediated Immunity (CMI). • To improve antibody titre. • To reduce vaccine failure. • To withstand heat stress. Trade Composition Trade Dose name Muramidase, Broiler Peroxidase, 1st wk: 3 gm/100 bird. Pulv. Oligosaccharides, 3rd week: 5 gm/100 bird. Lisovit Herbal Extract, 5th week: 10 gm/100 bird. Vitamin C, Layer/Breeder Vitamin E. 10 gm/100 bird. Pack size 10 gm, 100 gm 1kg Company Renata 216 Pulv. AIB vet Liq. Immolyte Liq. Nutrilac Soln. BETALYTE VET Unique combination of Lysozyme Hydrochloride, MOS, β-Glucan, Vitamin A, Vitamin C, Vitamin E, Zinc, Se & Anhydrous Glucose Glycine, Vitamin E, Vitamin C, Sodium Chloride, Potassium Chloride, Sodium Citrate, Yeast nucleins, aminonitrogen with lactoperoxidase and polysaccharide in a fortified base. Immunopotentiator Folic acid, Lactic Acid Each ml contains Betaine-250 mg, Vitamin-C-90 mg, Potassium Chloride-2 mg, Magnesium Chloride-4 mg, Calcium Chloride-40 mg & Sodium Chloride-20 mg 1 gm/1-2 Liter drinking water Chicks, grower and broiler: 5 ml per 100 birds for 5 to 7 days. Layers: 10 ml per 100 birds for 5 to 7 days. 1-3 ml/L drinking water 10 gm 100 gm SK+F 100 ml, 1L Square 200 ml, 1L Novartis 100 ml Acme Prevention: 1 ml/Litre drinking water for 3-5 days. During stress: 2 ml/litre drinking water for 3-5 days. Use of this solution may be continued if stress persists. Nutritional products Vitamin B complex (Vit B1, B2, B6) Each member of the B-complex has a unique structure and performs unique functions in the poultry’s body. These vitamins are vital for: ✓ Vitamin B1 (Thiamin) helps the body to break down carbohydrates, fat and protein to produce energy and affect enzymes that influence the muscles, nerves, and heart. ✓ Vitamin B2 (Riboflabin) helps the body process amino acids and fats, makes antibodies and red blood cells and maintain good vision & feathers. ✓ Vitamin B6 (Pyridoxine) helps the body break down protein, and helps maintain the health of red blood cells, the nervous system, and parts of the immune system. Indication: is specially used in the treatment of various manifestations of it’s component vitamin deficiency such as Polyneuritis, Curled toe paralysis, inapetance, All types of stress or where requirement are increased (carbohydrate-rich diet, pregnancy). Trade name Composition Trade Dose Pack size Company Pulv. Prithi WS Each 100 gm powder 1 gm / 1 litre drinking 100 gm Square contains – water or, 200 gm / 100 Thiamin HCl-5 gm, kg feed for 3-5 days. Riboflavin-1 gm. Pyridoxin HCl-2 gm, Dextrose monohydrate q. s. to make -100 gm. 217 Pulv. Acivit B1,B2, B6 Pulv. Thiamix-RP Pulv. Ribomix TP Vet Pulv. Vita-3 Pulv.Ultravita-3 Pulv. ESKAVIT B1 B2 Pulv. Ribothin Do Do 100 gm ACI Do Do Do 100 gm Techno Do Do Bengal 100 gm Acme 100 gm Popular 100 gm SK+F 100 gm Opsonin Each 100 g powder contains, Thiamin HCl-5 gm, Riboflavin-1 gm, Pyridoxin HCl-2 gm. DO Each kg powder contains; Thiamin hydrochloride (B1)- 50,000 mg Riboflavin (B2)-10,000 mg Thiamin: 5%, Riboflavin: 1% Do Prevention: 1 gm / 2 litre drinking water Treatment: 1 gm / 1 litre drinking water or, 10 gm / 4-5 kg feed for 3-5 days. Water : 1 gm of powder / 1 liter of water; 5 days. OR, Feed : 10 gm of powder / 4-5 kg of feed; 5 days. DO Vitamin B complex + Vitamin C Indication: is specially used in the treatment of various manifestations of it’s component vitamin deficiency such as Polyneuritis, Curled toe paralysis, inapetance, All types of stress or where requirement are increased (carbohydrate-rich diet, pregnancy). Trade name Composition Trade Dose Pack size Company Each g powder contains: Vitamin B1–2 mg Vitamin B2–4 mg 1-2 gm powder per liter Vitamin B6–1.5 mg of water for 3-5 Vitamin B12–10 mcg consecutive days. 500 g Pulv. Eskavit B+C SK+F Nicotinamide–7.5 mg Or container Pantothenic acid–4.5 mg 2 gm per kg of feed for 3Biotin–15 mcg 5 consecutive days. Folic acid–0.25 mg Vitamin C –50 mg Pulv. Rena B+C Each g powder contains: Do 10 gm Renata Thiamine Hcl 2 mg, 100 gm Vitamin B2 5.18 mg, Calcium d Pantothenate 4.91 mg, Vitamin B6–1.5 mg Nicotinamide 7.51 mg, Vitamin B12–10 mcg Folic Acid 0.26 mg, D Biotin 0.74 mg, Vitamin C–5 mg 218 Pulv. V-PLEX VET (B+C) Pulv. Becevit-Vet Pulv. Promix B+C Pulv. Ultravita B+C Pulv. Albivit B+C Each kg powder contains; Vitamin B1- 2,000 mg Vitamin B2- 4,000 mg Vitamin B6- 1,500 mg Vitamin B12- 10 mg Vitamin C – 50,000 mg Nicotinamide- 7,500 mg Pantothenic acid-4,500 mg Biotin- 15 mg Folic acid- 250 mg Vitamin B-Complex & Vitamin C Do Do 100 gm, 400 gm ACME Do Do Square Do Gentry Do Do 100 gm 500 gm Do Popular Do Poultry : 1-2 g/liter drinking water Animal : 1 g/10 kg body weight 100 gm Albion Vitamin B complex & Amino acid Purpose: A vitamin preparation to birds for better performance. Drug Interaction: It may reduce the antibacterial activity of Streptomycin, Tetracycline type drugs. It is contraindicated to use with Potassium and Neomycin. Trade name Composition Trade Dose Pack Company size Each ml containsVitamin B2- 2.0 mg Vitamin B6- 0.62 mg Broilers: 1 ml in 2-5 liter 100 ml, Liq. B-Com-Vit Vitamin B12- 6.25 mcg of drinking water for 3-5 Square 1L D-Panthenol- 1.25 mg days. Niacinamide- 37.5 mg Layers: 1 ml in 3-6 liter of DL-Methionine- 5.0 mg drinking water for 3-5 L-Lysine- 5.0 mg days. Choline Chloride- 5.0 mg Excipients - Q.S. Highlighting points: Vitamin B1 is one of the most essential elements of metabolism and multiplication of Eimeria spp, responsible for coccidiosis in poultry. Without B1, Eimeria spp cannot survive. So, it is advised to stop vitamin B-complex preparation as it contains vitamin B1 during coccidiosis in poultry. But, at the same time other B vitamins play a great role in red blood cell (RBC) production, metabolism and other physiological activities in poultry. So, it is not wise to stop B-Vitamins only for vitamin B1. B-Com Vit Liquid is such a preparation where vitamin B1 is absent. As a result B-Com Vit Liquid can be used in poultry at any time regardless the occurrence of coccidiosis. Vitamin A, D, E preparations Indication: Vitamin A, D3 & E deficiency, during vaccination, problems in fertility, hatching & incubation, feather picking, cannibalism, prevention of testicular degeneration in cock & lower ovum production in layer breeder. Trade name Composition Trade Dose Pack size Company 219 Soln. Es-ADE Soln. Acivit-ADE Soln. Revit ADE Soln. Megavit AD3E Soln. Renasol AD3E Soln. Nasol AD3E Each ml Solution contains vitamin A-100000 IU, vitamin D3-20000 IU vitamin E-20 mg. Do Each ml Solution contains vitamin A-100000 IU, vitamin D3-40000 IU vitamin E-40 mg. Each ml Solution contains, A-1 lac IU, D-20,000 IU, E-50 mg Each ml Solution contains, Vitamin A 10000000 IU, Vitamin D3 2000000 IU, Vitamin E 2000 mg. Vitamin A,D3,E 1-5 ml per liter of drinking water during 3-5 consecutive days Do Treatment: 2 ml per liter of drinking water during 35 consecutive days. Prevention: 5 ml per liter of drinking water during 35 consecutive days 1 ml/5-8 L drinking water 100 ml, 500 ml, 1L 500 ml 100 ml 100 ml, 500 ml, 1L Up to age 4 weeks – 5 ml/ liter water for 3 days. Layer – 1 ml/ litre water for 3 days. Up to age 6 months - 3 ml/ liter water for 3 days. 1ml/3-4 liter of drinking water. 100 ml, 1L 100 ml 500 ml 1000 ml Square ACI Opsonin Novartis Renata Gentry Vitamin D Indication: ✓ Fulfils dietary deficiency of Vitamin D ✓ Maintains proper egg, & meat production ✓ Ensures proper calcium absorption in poultry and ruminants ✓ Prophylactic and therapeutic use in case of retarded growth, thin egg shell, skinny shank, and calcium/phosphorus deficiency syndrome of poultry Trade Name Composition Trade dose Pack Size Company Liq. D-BalanceVitamin D3 1 ml/L drinking water for 3-5 days 100 ml, Square Vet 500 ml 1L Vitamin E + Selenium Indication: Any kind of Vitamin-E and/or Selenium deficiency. It should use during growing period. Enzootic Paralysis, Crazy Chick disease, Encephalomalacia, Exudative diathesis, Ascites etc. To increase egg production & hatchability. During Vaccination to increase antibody production & promote immunity. Trade Name Composition Trade dose Pack Company Size Susp. Rena Each ml suspension For prevention: 100 ml, RENATA Sel E contains1 ml/ 4 L water for 5-10 1 liter Vitamin E--80 mg days Selenium--0.6 mg For treatment: 220 Soln. Revit ES Soln. OSE Vet Each ml solution containsVit E: 450 mg Se: 0.4 mg Each ml contains Vit E acetate-100 mg Selenium – 0.2 mg 1-2 ml/ 2 L water for 5-10 days 1 ml/ L water for 5-7 days. Poultry: 1 ml / 1-2 liter water daily. Pigeon, Pet bird: 1 ml liquid/ liter water daily Treatment: 1 ml liquid/ 2 liter water for 5–10 days Preventive: 1 ml liquid/ 4 liter water for 5–10 days. 1-2 ml in 10 L drinking water for 5-10 days. Liq. E-Sel Each ml solution containsAlpha-tocopherol acetate100 mg Sodium Selenite- 500 mcg. Liq. Sel-E Nano Do Liq. E-vet plus Do Do Pulv. E-sel Each gram powder contains Alpha-tocopherol acetate100 mg Sodium Selenite- 500 mcg Pulv. Eskavit E Each gram powder contains; Vitamin E acetate BP 400 mg, Sodium selenite BP 0.4 mg (400 mcg) Poultry: 1 -2 gm powder/ kg feed or 0.5 – 1 gm / litre drinking water for 5 – 10 days 1 gm powder per 4-8 liters of water for 5-7 consecutive days, OR, 100 gm powder per ton of feed for 5-7 consecutive days. 100 ml OPSONIN 20 ml 100 ml 500 ml SK+F 100 ml, 1 liter SQUARE 100 ml 500 ml 1 L 100 ml, 500 ml, 1L 100 gm, 1 kg ACI 100 gm, 500 gm ACME SQUARE SK+F Vitamin K Action: Vitamin K is necessary for the biosynthesis of blood clotting factors. Indication: Poultry: ✓ To prevent Vitamin K deficiency syndrome in poultry. e.g. prolonged bleeding, large hematoma & severe hemorrhagic anemia etc. ✓ To prevent hemorrhage in case of coccidiosis, necrotic enteritis, ulceration etc. ✓ After treatment with sulfa drugs. Large Animal: For blood clotting caused by different factors. Trade name Composition Trade dose Pack Company size Pulv. K-10 Each gm powder containsPoultry: 1 gm per 10 liter of 10 gm, Square Menadione sodium drinking water for 3- 5 days. 100 gm bisulfite- 100 mg Large Animal: 1-10 gm per 50 Lactose q.s. to make kg body weight for 3-5 days. Action: 1 gm Medicated drinking water should be used within 24 hours. 221 Pulv. Rena-K Pulv. Vita-K Menadione 100 mg per gm DO Pulv. Nava-k DO Do 10 gm Renata For the treatment of Hemorrhage: 1 g/30-40 L drinking water daily for 5-7 days. For the treatment Coccidiosis and at the time of debeaking: 1 g/15 L drinking water for 3-5 days. DO 10 gm Acme 10 gm Navana Vitamin C Indication: Any kind of stress like heat stress, Adverse climatic condition, Transportation, Pullet replacement, Overcrowding, Culling, Vaccination, Anthelmintic use etc. Intestinal ulcers, scissoring ulcer or any kind of wound for proper healing by collagen synthesis. To prevent thin-shelled egg formation in case of excessive environmental temperature. During debeaking to prevent hemorrhage & stress. Supportive treatment in case of coccidiosis for healing of intestinal ulcer. Trade name Composition Trade dose Pack size Company Pulv. CevitEach gram contains L1 gm / 5 – 10 litre of drinking 100 gm, Square Vet Ascorbic Acid (Vit-C) water for 5 days. 1 Kg, 980 mg. Pulv. Do Do 100 gm, Acme Vitamix-C 1 kg Pulv. Rena-C Ascorbic acid 99% Do 1 Kg, Renata 100 gm Pulv. Revit C DO DO 100 gm, Opsonin 500 gm, 1 kg Pulv. Ascorbic acid-1000 DO 100 gm, Popular Ultravita C mg/gm 1 kg Pulv. Acivit C Do Do 100 gm, ACI 1 kg Pulv. Eskavit DO In water: 1 gm/ 5-10 liter for 3-5 1 kg SK+F C consecutive days or, In feed: 1-3 gm/ 1000 kg feed for 3-5 consecutive days Liq. Aquavit C Per ml contains 1 ml/L drinking water for 3-5 100 ml, Popular Ascorbic acid 30 mg. consecutive days 500 ml Liq. Envit-C Each 100 ml liquid 2-3 ml / litre of drinking water 100 ml Square contains extracts of – (0.4 ml liquid /kg b.wt.) daily for 1 Liter (Natural Emblica officinalis 3-4 consecutive days. Vitamin C) 66.66 ml & Piper longum 2.64 gm. Vitamin C + Glucose Indications: ✓ All types of stress conditions of poultry ✓ Prevention of early chick mortality ✓ Quick supplement of energy in chicks. Trade Name Composition Trade dose Pack size Company 222 Pulv. Glucovet Each g contains Glucose 980 mg and Vitamin C 20 mg. Pulv. NRG C DO Pulv. Albi Glucose-C (Vet) Pulv. Summer Cool Pulv. Maxcool (vet) DO Acetyl Salicylic Acid, Vitamin-C, Dextrose Each 100 gm contains Acetyl Salicylic Acid 6.7 gm, Vitamin C- 20 gm & Dextrose Anhydrous q.s.to 100 gm. 50 g/L drinking water. Glucovet mix water should be offered to chicks for 1st 24 hours of brooding. For Poultry: In Brooding: 50 gm/ litre water In All Stressed Conditions: 10 gm/ litre water DO 100 gm, 1 Kg Acme 500 gm SK+F DO Albion 1 gm/5 litres of water for 45 days 1 gm powder in 1 liter drinking water. 1 kg AlMadina Bridge 500 gm Container Mineral preparations Zinc preparations Indication: ✓ Increases growth and egg production ✓ Increases the Hatchability and productivity of Breeder and parent stock ✓ Helps to prevent any types of Diarrhea. ✓ Decrease the rate of sudden death. ✓ Poor feathering. Trade name Composition Trade dose Pack size n Sol . Zis-vet Each 5 ml contains Zinc Prevention: 2 ml in 1 liter 500 ml, (as Zinc Sulphate water for 5-7 days. 1L Monohydrate USP) 10 Treatment: 3 ml in 1 liter water mg. for 5-7 days. Syp. Soluzinc Do Do 500 ml, 1L Soln. XincDo 2-3 mL/ L in drinking water 200 ml, Care 500 ml, 1L Liq. ZINGA DO DO 100 ml, VET 500 ml, 1L n Sol . Ziflu Vet Each ml solution Prevention: 1 ml/2 litre of 100 ml, contains Zinc Sulfate drinking water. 1L Monohydrate BP-6 mg. Treatment: 1 ml/litre of drinking water. Soln. Ozinc Each ml contains, Zinc Do 100 ml 85 mg Liq. Each ml contains, Prevention: 1 ml/1 liter 100 ml, Remezinc vet Zinc sulphate drinking water for 5-7days 500 ml, monohydrate-6 mg, 1L Company Acme Popular SK+F Bio pharma Incepta Renata Bengal 223 Vitamin D3- 200 IU. Pulv. AvailaZn 120 Zinc amino acid complex. Zinc: 12%. Treatment: 2 ml/1 liter drinking water for 5-7days Laying hens, broilers and turkeys: Add 333 grams per metric ton of complete diet. 25 kg Renata Calcium preparations Indications: Layer: • Helps to minimize the inadequacy of Calcium & Phosphorous in diet • Prevents drop in egg production • Improves egg shell quality • Prevents cage layer fatigue, prolapse and cannibalism Broiler: • Ensures proper growth of bone • Prevents bone disorders • Ensures proper growth Pharmacology: ✓ Fulfill the Calcium & Phosphorus deficiency in the body. ✓ Vit-C helps in tissue repair, collagen synthesis and acts as an anti-stress vitamin. ✓ Vit-D3 maintains proper plasma calcium level in blood. ✓ The Vit- B12 helps in Haemopoiesis (Blood cell formation). ✓ The Citric acid keeps intestinal PH to 6 for proper absorption of Calcium & Phosphorus from intestine. Problems due to Calcium and Phosphorus deficiency in poultry: ✓ Bones become weaken which may cause Osteoporosis and many other diseases. ✓ Layer may caught by Cage Layer Fatigue disease. ✓ Thin and soft shelled eggs. ✓ Abnormal shaped eggs. ✓ Lower egg production. Trade Name Composition Dose Pack Size Company Pulv. Calvet-FP Each 100 gm powder Poultry 500 gm, ACI contains: 1 gm powder mix with 11 kg Calcium Hydrogen 2 litres of drinking water Phosphate- 13.18 gm (eqv. for 3-5 consecutive days. to Phosphorous 3.00 gm & Or Calcium 3.88 gm) 100-200 gm powder mix Calcium Carbonate-5.30 with 100 kg of feed for gm (eqv. to Calcium 2.12 3-5 consecutive days. gm) Cyanocobalamine- 0.0015 gm Ascorbic Acid- 1.00 gm Vitamin D3- 50,000 IU Citric Acid- 3.00 gm Liq. Calplex Each litre solution 2.5 ml per litre drinking 100 ml, SQUARE containswater for 5-7 days. 1 liter 224 Soln. AciPlex Vet Liq. Minacal Plus Pulv. Cal-P Pulv. CP-vet Pulv. Calvita P Calcium-3.40 % Phosphorus-1.70 % Vitamin D3-2,000,000 I.U. Do Calcium enriched with vitamins, minerals and Shatavari extract Each gm contains – Elemental Calcium- 60 mg Elemental Phosphorus- 30 mg Vitamin-B12- 15 mcg Vitamin C- 10 mg Vitamin D3- 500 IU Citric acid- 30 mg Each g contains, Calcium- 42 mg Phosphorus- 15 mg Vitamin B12- 10 mcg Vitamin D3- 400 I.U Vitamin C- 6 mg Citric Acid- 0.27 g Do Do Broiler and Layer: For 100 birds, Chicken: 20 ml/day Broiler and pullet: 50 ml/day Layer and breeder: 100 ml/day 1 gm / 1.5 – 2 litre of drinking water for 3-5 days. 100 ml, 500 ml, 1L 5L ACI Incepta 500 gm, 1kg SQUARE 1 gram/ 1.5-2 liter drinking water In case of extreme stress, 2 gram/ 1.5-2 liter drinking water 500 gm ACME Do Do Gentry Di-Calcium Phosphate Benefit: • Formation of skeletal structure on of the Broiler & Layer • Formation egg-shell • Maintaining adequate shape & size of egg • Prevention of soft-shelled / shell-less / crack-shelled eggs • Prevention & treatment of rickets, osteomalacia, osteoporosis, osteopetrosis & anemia in poultry • Increasing hatchability of egg in breeder bird, • Increasing production percentage • Improving FCR Trade Name Composition Trade dose Pack Company Size Pulv. Square Calcium--23% Phosphorus-- 0.5% to 1.2% in poultry feed, 25 Kg Square DCP Granular 18% bag. Pulv. ACI DCP Each 1 kg contain 1-5 kg/ton feed 1 kg, ACI Gold Ca phosphate-90%, 5 kg MgSO4: 2%, NaCl-6%, ZnO: 0.02%, I2, Casin, Frocto oligosaccharide: 0.02% 225 Pulv. DCP plus Pulv. Super DCP Trace element (Fe, Mn, I2, Cu, Zn, Co)- 1.96% Each 1 kg contain Di-Ca phosphate-90%, MgSO4: 2%, NaCl-6%, Trace element (Fe, Mn, I2, Cu, Zn, )- 2 % Each kg Contains Di-Calcium Phosphate-900 g Magnesium Sulphate-20 g Sodium Chloride-60 g Elements (Fe, Mn, I, Cu, Zn, Co)-20 g Do Do Opsonin 1-3 kg/ton feed 1 kg AgroVet Pack Size 20 ml 100 ml 500 ml Company Multimineral preparation Usage ✓ Removes essential mineral deficiencies in poultry ✓ Improves FCR ✓ Improves meat & egg production ✓ Improves egg & egg shell quality ✓ Improves hatchability ✓ Improves bone formation ✓ Improves Immunity Trade Name Generic Name Soln. OMB vet (Organic Multi mineral Booster) Each 100 ml contains Copper--2500 mg Zinc--2500 mg Iron--2000 mg Manganese--2000 mg Selenium-- 30 mg Chromium--1.6 mg Dose Poultry: 1 ml/2-3 L drinking water. Pigeon, Pet bird: 1 ml/L drinking water SK+F Vitamins + Mineral + Amino Acids Trade Name Soln. Vitalamino forte vet Composition Each 100 ml contains Vitamin A--2000000 IU, Vitamin D3-500000 IU, Vitamin E--500 mg, Vitamin B1--100 mg, Vitamin B2--200 mg. Vitamin B6--200 mg, Vitamin B12 --1 mg, Vitamin C--300 mg, Vitamin K3--100 mg. Biotin--200 mcg, Sodium (chloride)--500 mg Sodium propionate-500 mg, Magnesium (sulphate)-150 mg. Manganese (sulphate)--60 mg. Trade dose Poultry: 1 ml/4 liter of drinking water. Pack Size 100 ml, 500 ml, 1L Company Acme Pigeon, Fancy Bird: 1.5 ml/liter drinking water. 226 Soln. CozinVet (Mineral & Organic Acid) Liq. Boostbryd Zinc (sniphate)--60 mg. Iron (sulphate)--2 mg. Potassium--100 mg, Glutamic acid--350 mg, Lactic acid--400 mg, Citric acid--20 mcg. Alanine--75 mg. Arginine--100 mg. Potassium citrate--300 mg, Cystine--20 mg. Glycine--300 mg, Histidine--52.5 mg, Isoleucine-50 mg. Lysine--500 mg. Methionine--150 mg. Phenylalanine--90 mg. Proline-90 mg, Serine--90 mg, Threonine--300 mg. Tryptophan--60 mg. Tyrosine--65 mg & Valine 80 mg Zinc sulfate- 15%, Copper sulfate-8% Lactic acid-8% Acetic acid- 10% Each Liter containsVitamin A 2500000 I.U. Vitamin D3 500000 I.U. Vitamin E 3750 mg Vitamin B1 3500 mg Vitamin B2 2000 mg Vitamin B6 2000 mg Vitamin B12 10000 mcg Vitamin K3 250 mg Proline 920 mg Serine 940 mg Tyrosin 670 mg Crude Protein 1.75 % Crude Fiber 0.01 % Crude Fat 1.52 % Crude Ash 0.30 % Sodium 0.07 % Biotin 2000 mcg Potassium— 0.05 % L-Isoleucine 887 mg Lysine 0.11 % L-Valine 898 mg Methionine 0.02 % L-Arginine 1341 mg L-Cystine 0.02 % L-Phenylalanine 933 mg L-Threonine 0.06 % 1 ml/2 Liter of drinking water for 5-7 days. 100 ml Bottle, 1 Liter. Square Poultry: 1-2 ml per liter of drinking water for 5-7 days. 100 ml, 1 Litre. SQUARE 227 Liq. Risovit plus Liq. Vitastar Pulv. Rena WS Pulv. Vitapoultry Pulv. Vitamix ws vet Alanin 3460 mg LTryptophane—0.02 % Histidine 470 mg Glycine—0.07 % Each liter contains – Vit A: 12,000,000 IU, D3: 3,000,000 IU, E: 5000 IU, K3: 1000 mg, B1: 2000 mg, B3: 15000 mg, B5: 10000 mg, B6: 1000 mg, B12: 10 mg, C: 4000 mg, Arginine HCl: 1500 mg, Dl-Methionine: 3000 mg, Lysine HCl: 1200 mg. Glysine: 7000 mg, Threonine: 6000 mg Each 10 ml contains: Vitamin A—120,000 IU Vitamin D3—60,000 IU Vitamin E—15 mg Vitamin H (Biotin)—1.5 mg Vitamin C—10 mg Zinc—100 mg Cobalt—1 mg Selenium—1 mg Taurine—1,000 mcg Vitamin A 1000000 IU, Vitamin D3 250000 IU, Vitamin E 200 mg, Vitamin K3 160 mg, Vitamin B1 120 mg, Vitamin B2 320 mg, Vitamin B6 120 mg, Vitamin B 120.2 mg, Vitamin C 3000 mg, Nicotinamide 200 mg, Pantothenic Acid 184 mg, D biotin 1 mg, Folic Acid 10 mg Vitamins + Amino acid Each 10 g contains Vitamin A 1000000 IU, Vitamin D3 250000 IU, Vitamin E 200 mg, Vitamin B1 120 mg, Vitamin B2 320 mg, Vitamin B6 120 mg, Vitamin B12 0.2 mg, Vitamin C 3000 mg, Vitamin K3 160 mg, Nicotinamide 200 1 ml/ L DW for 5-7 days 1L Novartis For Oral Administration Chicks: 5 ml/100 birds daily Growers: 7 ml/100 birds daily Layers: 10 ml/100 birds daily 100 ml Square 10 gm, 100 gm Renata 100 gm ACI 10 gm 100 gm sachet. Acme For Treatment: 1 gm/ 2.5-5 liter of drinking water for 3-5 days. For Prevention: 1 gm/ 510 liter of drinking water for 3-5 days. Administer 1 g per 2-4 Lit. of drinking water for 3-5 consecutive days. Prevention: 1 g/ 5-10 liter drinking water or 1 g/4 kg feed for 5-7 days. Treatment: 1 g/ 2.5-5 liter drinking water or 1 g/2 kg feed for 3-5 days. 228 mg, Pantothenic acid 184 mg, D-Biotin 1 mg & Folic acid 10 mg. Amino Acid Trade Name Liq. Panamin Generic Name Amino acid + trace minerals Pulv. DLMethionine DL-Methionine- 99% Pulv. L-Lysine Dose Broiler chicken- 5-10 ml / L drinking water Breeding poultry- 0.5 - 1 ml / L drinking water For Broiler: 50-100 gm / 100 kg feed continue For Layer: 40-80 gm / 100 kg feed continue 50-100 gm / 100 kg feed continue Pack Size 100 ml 1 L plastic bottle. Company Square 25 kg bag. Square L-Lysine 25 Kg Square Monohydrochloride bag. 98.5% Indication: L-Lysine HCl improves the efficiency of protein utilization in animal feeding. It increases the efficiency of animal protein production. It promotes the meat quality & increases the growth rate of Broiler. L-Lysine HCl protects bird from heat stress. Feed premix Trade name Composition Trade Dose Pulv. ESKAVIT BROILER SPT PREMIX Each 2.5 kg contains Vitamin A 1000—10 MIU Vitamin D3 500—2.40 MIU Vitamin E50—23 gm Vitamin K MNB—2.33 gm Vitamin B1—2.00 gm Vitamin B2 SG80—5.00 gm Vitamin B6—3.00 gm Niacin/Nicotinic acid30.00gm Cal-D-pantothenate—12.5 gm Vitamin B12—12.00 mg Folic acid—0.80 gm Biotin—60.00 mg Copper Sulfate Pentahydrate —10.00 gm Ferrous Sulfate Anhydrous— 60.00gm Potassium lodide—0.40 gm Manganese Oxide—60.00 gm Zinc Sulphate Monohydrate—50.00 gm Sodium Selenite—150.00 mg Antioxidant—5.00 gm Anticaking agent—12.50 gm Cal Carbonate—QS to 2.5 kg Add 2.5 kg premix per ton of feed. Pack size 25 kg shipper Company SK+F 229 Pulv. Square Premix Broiler Pulv. Square Premix GS Pulv. Square Premix Layer Pulv. RenaBreeder Premix Pulv. RenaBroiler Premix Pulv. RenaLayer Premix Pulv. StressKill WS Vitamins, Minerals, Others 10 kg Pack Do Square Do 250 gm / 100 kg feed continue. Do Do Do Do Do Vitamin, trace minerals, amino acid & calcium 2.5 kg Renata Do To make each 1000 kg feed mix 2.5 kg of Rena Breeder. Do Do Do Do Do Do Do 1 gm / 5 litre of drinking water or, 20-40 gm / 100 kg feed for 4-5 days. 100 gm sachet. Square Liquid. Farmatan Each 100 gm powder contains Vitamin A 25,00,000 IU Vitamin D3 3,00,000 IU Vitamin E (50%) -5,000.00 mg Vitamin K3 (10%)-2,000.00 mg Vitamin B1—1,250.00 mg Vitamin B2 —2,500.00 Vitamin B6 --1,250.00 mg Vitamin B12 (0.1%)—250.00 mg Nicotinamide—2,500.00 mg Calcium-D Pantothenate-2,500.00 mg Vitamin C —5,000.00 mg Folic Acid 125.00 mg Biotin 10.00 mg Cobalt Sulphate, 7H2O— 10.00 mg Copper Sulphate, 5H2O-150.00 mg Ferrous Sulphate, 7H2O— 100.00 mg Potassium Iodide—10.00 mg Manganese Sulphate, 1H2O—1,000.00 mg Zinc Sulphate, 7H2O— 1,000.00 mg DL –Methionine-1,000.00 mg L–Lysine-2,000.00 mg Herbal extracts + Calcium butyrate + Essential oil 1L 10 L ACI Pulv. Galibiotic Medium Chain Fatty Acids with Carrier. 1- 4 L per 1000 liter of drinking water 8-12 hoursly/day for 3-5 consecutive days. Broiler/Layer (up to Laying): Use per ton of finished feed as follows: 1 Kg, 25 Kg Square Do 230 0-10 days: 1.6 Kg 11-21 days: 1.2 Kg 22-35 days: 0.8 - 1.2 Kg >35 days: 0.4 – 0.8 Kg Galibiotic Indication: To improve FCR, digestive & absorptive capacity of small intestine, litter quality, flock uniformity, feed intake etc. To control salmonellosis, necrotic enteritis & reduce chicks mortality in broiler & pullet in layer. Pulv. Bio-Surf Each 1000 gm powder Broiler : 500 gm – 1 Kg per 1 Kg Square contains: Ton of Feed continue. 20 Kg. Hydrolysed Lecithins-Layer : 250 – 500 gm per Lyso – Phospholipids: 20 gms Ton of Feed continues. Phosphatidyl Choline: 33 gms Tri-methyle Glycine: 5 gms Organic Phosphorus: 7.6 gms Active Polypeptides: 10.2 gms Methyle Donars: 38 gms Gut Stabilizers: 2 gms Base: Calcium Carbonate qs Bio-Surf Indication: For digestibility of fat and availability of energy as it acts as natural emulsifier and improves absorption of fat soluble vitamins and other nutrients. Pulv. Fishlog Poultry Meal – CP 60% (min.) In poultry feed, 5-20 kg 25 Kg Square (Protein mixed with each 100 kg bag Supplement) finished feed Fishlog Indication: To fulfil dietary requirement of protein in poultry, To ensure proper growth and production, To ensure balanced protein in feed Pulv. Fishtin Pure Fishmeal – CP 60% Up to 10% in poultry Do Do (min.) Egg formula Indications: To increase production, prevention & treatment of sudden fall in egg production of laying hen, stresses (Vaccination, Weather change, Debeaking etc), during first production of pullet and prevention & treatment of diseases caused by vitamin deficiency. Trade name Composition Trade Dose Pack Company size Each g powder contains During Starting Vitamin A-3000 I.U production: 1 g/L Vitamin D3-1000 I.U drinking water for first 5 Vitamin E-2 mg weeks followed by 1 g/3Vitamin K3-2 mg 4 L of drinking water Pulv. Vitamin B1- 0.5mg monthly for 5 Acme’s Egg Vitamin B2-2 mg 100 gm Acme consecutive day. Formula Vitamin B6- 0.3 mg Vitamin C -10 mg Sudden fall of egg Vitamin B12 - 2.2 mg production: 1 g/2-3 L of Nicotinamide - 15 mg drinking water for 5-7 Folic Acid- 0.1 mg consecutive days. Calcium Pantothenate -5 mg ১ গ্রাম/ ভকক্সজ খাটিয ৩-৫ হিন। Pulv. I2- 10 gm 100 gm ACI Promone Casein- 90 gm 500 gm Plus Fructo-oligosaccharide- 20 gm Protein & Wheat- q.s 231 Growth promoters Benefits: ✓ Increasing appetite, digestion, weigh gain. ✓ Probiotics. ✓ Increase the activity of vaccines. Trade name Composition Trade Dose Pulv. Gro-Up Minerals, Yeast 1 gm/ kg of feed Each gm contains: 1 gm/2-3 L drinking water for Pulv. Promax Bacillus subtilis, B. 7-10 days coagulans, Saccharomyces 20 gm/100 kg feed for 10-14 9 boulardii 4.5Х 10 CFU days Soln. Amivet Multi Vitamin, Amino 1 ml/3-4 liter drinking water. Acids Pack size 1 kg 100 gm Company ACI SK+F 100 ml 500 ml 1L Gentry Prebiotics and Probiotics Indication: • To reduce pathogenic micro-organism (Salmonella, Clostridium, E. coli etc.) concentration in gut. • To reinforce intestinal microflora equilibrium • To stimulate poultry immune system • To increase production performance in layer & breeder. • To improve FCR in broiler birds. Precautions: For better result do not administer with antibiotic(s) in oral route. Trade Name Composition Trade Dose Pack Size Company Pulv. Rumi Each 24 gm sachet 48 gm per 100 kg feed for 24 gm Popular cell contains: 3-4 days orally, sachet Saccharomyces cerevisiae 10X1010 CFU Lactobacillus sporogenes 10X107 CFU Aspergillus oryzae 10X107 CFU Biotin-20 mg DL-Methionine-8 gm Zinc Sulphate-400 mg Cobalt Sulphate- 80 mg Copper Sulphate-200 mg Fructo-Oligosaccharide- 1 gm Excipients q.s Pulv. Saccharomyces cerevisiae Per Ton of finished Feed: 100 gm, Square LEVUCELL type boulardii (CNCM IBroiler 1 kg & SB 20 1079)-- 2.0 x 1010 cfu/gm Pre-starter--100 gm 20 kg Starter--50 gm Finisher--25 gm Layers Chick--100 gm Grower--50 gm 232 Pulv. LEVUCELL SB 10 ME TITAN Saccharomyces cerevisiae type boulardii (CNCM I1079) 1.0 x 1010 cfu/gm. Pulv. Probiozyme Each kg contains, Bacillus subtilis 1.0x108 CFU, Bacillus licheniformis 1.0x108 CFU, Lactobacillus acidophilus 1.0x104 CFU, Lactobacillus plantarum 1.0x104 CFU, Cellulase 10,00,000 Unit, Xylanase 10,00,000 Unit, Beta-glucanase 5,00,000 Unit, Alpha-amylase 15,00,000 Unit, Protease 10,000 Unit, Phytase 25,000 Unit Each 1 kg contains – Bacilus subtilis: 5.7×109 CFU, Aspergillus oryzae: 1.9×109 CFU, Protease: 5000 Unit amylase: 21,000 unit, FeSO4: 100 gm, yeast culture: qs. Each gram contains Bacillus subtilis 1x109 cfu, Lactic Acid Bacteria 5x108 cfu, Saccharomyces cerevisiae 1x108 cfu, (Probiotics & Enzymes) Pulv. Nexpro Pulv. PROZYME VET (Probiotic, Prebiotic, Layer--25 gm Breeders Chick--100 gm Grower--50 gm Layer--50 gm Per Ton of finished Feed: Broiler Pre-starter--200 gm Starter--100 gm Finisher--50 gm Layers Chick--200 gm Grower--100 gm Layer--50 gm Breeders Chick--200 gm Grower--100 gm Layer--100 gm Poultry (breeder, layer, broiler): 250-500 grams per ton of complete feed or 1 gm per 3-4 liters water. 1 kg & 20 kg. Square 10 gm 100 gm Square Layer: 50-100 gm/100 kg feed. Broiler: 100 gm/100 kg feed. 1 kg ACI Broiler & Pullet: 1-2 g/L drinking water or per kg fed for 5-7 days & repeat when necessary. Laying Hen: 0.8-1g/L drinking water or per kg fed for 5-7 days. It is better 100 g, 500 g 1 kg sachet. Acme 233 Enzymes, Vitamins & Minerals) Pulv. Poultrystar Sol Pulv. Grobiio-Pro vet Streptomyces spp. 5x107 cfu, Protease 1000 Unit, Amylase 10000 Unit, Cellulase 50 Unit, Vitamin A 10000 IU, Vitamin D 1000 IU, Vitamin E 20 IU, Vitamin B Complex 15000 ppm, Niacin 8000 ppm, Pantothenic Acid 10000 ppm, Iron 60 ppm, Manganese 30 ppm, Zinc 10 ppm, Copper 30 ppm, Maltodextrin 25000 ppm, Oligofructose 50000 ppm Bio peptide 20000 ppm. Each kg contain Enterococcus faecium 5×10 12CFU, Pediococcus acidilactici 5×10 12CFU, Lactobacillus reuteri 5×10 12CFU, Lactobacillus salivarius 5×10 12CFU Each gram powder contains- (Bacillus subtilis, Bacillus licheniformis, Bacillus coagulans, Saccharomyces boulardii)2 Billion CFU, Amylase-30 U, Lipase-100 U, Pectinase10 U, Protease-200 U, Beta Glucanase-15 U, Beta Xylanase-2000 U, Vit-A1000 IU, Vit-D3-200 IU, VitE-8 mg, Vit-K-2 mg, Zinc Sulphate-9 mg, Cobalt – Sulphate-4 mg, Copper Sulphate-20 mg, DL Methionine-20 mg. to use for 7 days each month. 20 gm/1000 birds 10 gm Renata 100 gm 500 gm Incepta (With drinking water) Broiler, Shonali & Pullet: 1 gm/1-2 liter once daily for 3-5 days. Layer & Breeder: 1 gm/1-2 liter once daily for 3-5 days or 0.5 gm/kg feed for 5-7 days. Enzymes Indication: ✓ For laying hens: to improve digestion & production performance, egg quality and lengthen peak production period. ✓ For broiler chicken: to improve digestion & FCR. ✓ Improves gut health; reduces the incidence of bacterial diarrhea. Trade name Composition Trade Dose Pack size Company 234 Liq. Polzyme Liq. Liquid enzyme Pulv. Q-zyme Pulv. Rena Phytase 400 Each 1000 ml contains: Protease - 400000 IU Cellulase- 100000000 IU Xylanase - 1500000 IU Lipase- 6500 IU Amylase - 250000 IU Pectinase- 30000 IU B-Glucosidase - 10000 IU Galactosidase - 10000 IU Arabinase- 7000 IU Multi enzyme Pepsin, Pancreatine Lypase, Cellulose, Concentrated Enzymes Phytase Enzyme 400 ftu per g. Pulv. Alquerzim Each 1 g containsPepsin- 50 mg Pancreatin -100 mg Lipase - 10 mg Cellulase- 20 mg Pulv. ACMEZYME Cellulase, Xylanase, Protease Amylase, Phytase, Pectinase Invertase, Hemicellulase, Lipase, -Galactosidase. Pulv. ESKAZYME PLUS Each gm powder contains; Cellulase 28,000 Unit Xylanase 6,000 Unit Beta glucanase 700 Unit Amylase 40,000 Unit Pectinase 70 Unit Protease 3,000 Unit Lipase 5 Unit Phytase 750 Unit Mannanase 60 Unit Each Kg contains Enzymes Cellulase-180,000,000 U Amylase-125,000 U Xylanase -1,800,000 U Phytase- 200,000 U Protease-16,000 U Pulv. Caplix 1-2 ml Liquid per Litre of drinking water regularly. 250 ml Square 1-2 ml Liquid per Litre of drinking water regularly. 1 gm 1-2 ltr of drinking water for 3-5 days. 100 ml, 500 ml 100 gm, 500 gm Navana AlMadina Layer upto 1 kg/ton of feed. Broiler upto 1.5 kg/ton of feed. Via water: 0.5 – 1g per 1 liter of drinking water for 5 to 7 days. Via feed: 1g per 1 kg of final balanced feed for 5 to 7 days. Powder Layer: 150 gm/Ton of Feeduse regularly Broiler: 200 gm/Ton of Feed-use regularly Breeder: 150gm / Ton of Feed-use regularly Liquid 0.5-1 g per liter of drinking water 350 to 500 gm per ton of feed 1 kg Renata 10 gm, 100 gm ACI 100 gm sachet ACME 1 kg sachet & 25 kg bag SK+F 25 kg Speed 350 g per Tonne of Feed 235 Liq. Nutriplex (Digestive Enzyme with Carminative Feed Supplement) Lipase- 40,000 U Pectinase-7000 U Probiotics Lactobacillus acidophilus -1 billion CFU Saccharomyces boulardii -1 billion CFU Bacillus subtilis natto -1 billion CFU Bacillus licheniformis -1 billion CFU Each 5ml contains Amylase (1:300) 85mg, Papain 25 mg, Pancreatin 2.15 mg, Swertia Extract 2.5 mg, Sodium Bi-Carbonate 20 mg, Dill Oil 0.0015 ml, Iron 2.5 mg, Ajwain Oil 0.005 ml, Strychnos Tincture 0.010 ml 5 ml/100 chicks (1 ml/2 Liter drinking water bid daily) Or 10-15 ml/100 birds (1 ml/Liter drinking water daily) 100 ml 500 ml Square Phospholipid Choline Pharmacology: Choline Chloride helps for the production & maintenance of cell. It prevents excess deposition of fat into liver by metabolism of fat. It helps for the production of Acetylcholine essential for the transmission of nerve impulse. Choline Chloride is essential for transamilation reaction (Transamilation reaction: Transfer of amino group between two compound for the formation of new essential compound). It is essential for detoxification reaction. Cause of deficiency: Excess dietary protein, fat or fatty substance demand excess Choline in the body as a result this condition causes Choline deficiency. Indication: ✓ Perosis in Chick. ✓ To prevent decreased egg size. ✓ To increase production percentage. ✓ For mobilization of excess fat from the liver (Fatty Liver Syndrome), ✓ To decrease chick mortality during rapid growth. Trade name Composition Trade Dose Pack size Company Choline Chloride Poultry: 1-2 ml/L drinking water for 75% 7-10 days Liq. Fitbird 1 Liter Square Pet bird: 1 ml/L drinking water for 7-10 days Each ml contains, Per kg complete feed (88% dry Choline Chloride matter), 750 mg Chickens starter -0.95 - 1.67 ml Liq. Nava 1100 kg Chickens pullets- 0.60 - 0.95 ml Navana Choline 75 IBC Laying hens- 0.71 - 1.19 ml Breeding hens- 0.95 - 1.43 ml Broiler- 0.71 - 1.43 ml 236 n Sol . Liverex Vet Choline Chloride, Inositol, DL Methionine, Vitamins 1 ml/ 2 liter of drinking water for 57 consecutive days. 100 ml 500 ml 1000 ml Gentry Pack Size 100 gm Company Acme Pack Size 100 gm Company ACI Dose 1 mL / L of drinking water for 5-7 days Pack Size 100 mL 500 mL Bottle. Company SK+F Do 100 ml 500 ml ACME Do 500 ml Gentry Lecithin Indication in Poultry: ✓ Fatty liver syndrome ✓ Improve FCR ✓ Increase body weight gain ✓ Increase egg production ✓ Reduce the risk of stroke ✓ Increase digestion Trade Name Composition Pulv. LECIPHOS Lecithin 95% Trade dose 1-2 g/kg feed daily Lysolecithin Indication in Broiler and Layer: ✓ Make easily digestable fat containing feed ✓ Produce extra energy in body ✓ Improve feed quality ✓ Improve FCR ✓ To gain growth of broiler and increase egg production of layer Trade Name Composition Trade dose Pulv. Lysolecithin Broiler: 50-60 g per 100 kg feed or 1 g Eurolipid per 2-3 liter drinking water for 7 consecutive days. Layer: 40-50 g per 100 kg feed or 1 g per 3-4 liter drinking water for 7 consecutive days. Hematinic mixtures Usages: ✓ To Reduce anemia by production of RBC ✓ To increase feed Intake ✓ To increase metabolism Trade Name Generic Name Soln. HIMAFILL Each ml contains Ferrous Sulphate--0.5 mg, Copper Sulphate--0.2 mg Zinc Sulphate-- 0.2 mg Cobalt Sulphate--0.1 mg Vitamin B12 BP--0.1 mg n Sol . Ferovet Each 100 ml contains, Iron- 50 mg Copper - 20 mg Cobalt - 10 mg Zn -20 mg B12 -10 mg Soln. Feromin Vet Do 237 Electrolytes Mode of action: Increase the amount of necessary mineral and maintain electrolyte balance in the body. Indications: Diarrhoea, Dehydration, Stress due to transportation, antibiotic therapy, electrolyte imbalance, mineral deficiency. Trade Generic Name Dose Pack Size Company name Pulv. Each Kg Electromin® Powder 1 gm / 2 Litre of 20 gm, SQUARE Electromin containsdrinking water or 1 kg, Sodium bicarbonate BP - 500.0 gm 100 – 200 gm / 100 20 kg Sodium Chloride BP - 256.1 gm kg feed for 4-5 days. Pot. Chloride BP- 50.0 gm Dextrose BP- 180.0 gm Vitamin A- 1.0 gm Zinc sulphate BP- 7.9 gm Calcium Chloride BP- 2.5 gm Mag. Sulphate BP - 2.5 gm Pulv. Electrolytes + Vitamin A + Dextrose 1.25 gm in 1 liter 1 kg Popular E-Lyte drinking water for 35 days or 3 gm in 1 kg feed for 3-5 days Pulv. In per kg – 1.5 gm/L water daily 100 gm TECHNO ElectroNaHCO3: 500 gm, 500 gm, Plus Dextrose anhydrous: 175.04 gm, 1 kg, KCl: 50 gm, NaCl: 266 gm, 25 kg Vit A: 2,000,000 IU, Vit D3: 500,000 IU Pulv. Na, K, Mg, Ca, Zn, HCO3, Cl, Vit A, 1 gm/1.5-2 Lwater 500 gm, SK+F Eskalyte Dextrose 1 kg, 20 kg Pulv. Each 25 g contains With water: 1.25 g ACME Glucolyte Sodium bicarbonate BP--12.5 g GLUCOLYTE mixed 25 gm, Sodium chloride BP--6.65 g with 1 L water for 310 kg Potassium chloride BP--1.25 g 5 days. 20 kg Vitamin A BP--50,000 IU With feed: 2 g mixed Glucose anhydrous BP--4.50 g with 1 kg feed for 3-5 days. Pulv. NaHCO3, KCl, NaCl, Vit A, Glucose 2-4 gm/L water daily. 25 gm, OPSONIN Oralyte 500 gm, 1 Kg Pulv. In per kg – 1-1.5 g powder 1 kg NAVANA Dexolyte Dextrose Anhydrous + Potassium mixed with 1 L water Chloride + Sodium Bicarbonate + for 3-5 days. Sodium Chloride + Vitamin A: 18 gm + 5 gm + 50 gm + 26.6 gm + 20 Lac IU Pulv. Each 100 gm Powder contains1.5 gm / 1 Litre of 100 gm, Bengal Remelyte Sodium bicarbonate BP-50.0 gm drinking water or 500 gm, Sodium Chloride BP- 26.6 gm 100 – 200 gm / 100 1 kg Potassium Chloride BP- 5.0 gm kg feed for 4-5 days 238 Liq. Energy chicks Pulv. Betain-Vet Dextrose Anhydrous- 17.5 gm Vitamin A- 200000 IU Vitamin D3 - 50000 IU 50% dextrose 1-1.5 L/500 chicks Betaine Hydrochloride 1L, 500 ml 500 gm Sachet, 25 kg bag. Popular Poultry: 0.5 – 1 kg Square per ton of complete feed or 1 gm per litre of DW for 25-30 days. Rabbit: 1 - 2 kg per ton of complete feed. Indication of Betain-vet: Enhances stress resistance, Saves methionine to cut feed costs, Regulates osmotic pressure to maintain cell water balance, Improves meat quality, Feeding stimulation Liver tonics Indication: is indicated in conditions of disordered metabolism and infectious diseases to help overcoming vitamin deficiencies. Benefits: ✓ Helps in regeneration of liver ✓ Overcome deficiency of vitamin ✓ Increases function of liver in case of indigestion & infectious diseases in poultry & livestock ✓ Gives extra energy & repair liver immediately in case of infection when stored vitamins & energy sources are decreased ✓ Choline chloride, vitamin- B12, liver extract, inositol prevents fatty change of liver. Sometimes remove excess fat from the liver. ✓ The B-vitamins are components of enzyme system, which needed for metabolism of carbohydrate, fat & protein Trade Name Composition Trade dose Pack Size Company Liq. Liva vit Each Litre containsBroiler & Layer: 1 ml / 1-2 100 ml, SQUARE Vitamin B1- 5,000 mg Liter of drinking water for 1 liter Vitamin B2- 2,000 mg 5-7 consecutive days. Vitamin B6- 2,000 mg Vitamin B12 - 10,000 mcg Vitamin K3- 650 mg Folic Acid- 300 mg Nicotinamide- 60,000 mg Liver extract - 200 mg Vitamin B5- 11,000 mg Inositol- 1,000 mg Cholin Chloride- 50,000 mg DL-Methionine- 50,000 mg Liq. Superliv Andrographis paniculata Per day per 100 birds, 500 ml ACI (Kalmegh), Chicks- 5 ml 5L Azadirachta indica (Neem), Growers- 10 ml Achyranthes aspera Layers/Broiler/Breeder(Chirchita), 20 ml Eclipta alba (Bhringraj). Administer Superliv Liquid by mixing in morning water for 7 days. Duration 239 Liq. Hepatovit Liq. Hepafit Vet Liq. Superliv Liq. Renaliv Liq. HepaAmine Liq. Hepatonic প্রহত্ ১০০ হম. হল. ভত্ রটয়টছআফানাহমক্সিস হলস্টাহচয়া- ২০০ হম. গ্রা. োরহমনাহলয়া ভচবুলা- 800 হম. গ্রা. হরয়াম এটমাহি- ২৫০ হম. গ্রা. এনটরাগ্রাহফস ভ হনকুলাো- ২০০০ হম. গ্রা. বারটবহরস এহরসোো-800 হম. গ্রা. ও অনযানয ভেষজ উ ািান এবং হেোহমন হব১- ১৫ হম. গ্রা. হেোহমন হব- ৫. ৮ হম. গ্রা. হনটকাষ্টেনামাইি- ৮৪ হম. গ্রা. হেোহমন হব১২- ১০ হম. গ্রা. ইটনাহসেল- ২০০ হম. গ্রা. ভকাহলন বাইোরটেে- ৫ হম. গ্রা. of usage may be extended in severe conditions Poultry: 1ml/L drinking water for 5-7 consecutive days. Or for 100 birds: Chicks 5 ml, grower 10 ml and finisher 20 ml daily. 100 ml, 500 ml ACME 100 ml, 500 ml 1 Liter bottle. Acme Do 500 ml, 1 L ACI Do 250 ml, 500 ml, 1 L 100 ml, 500 ml RENATA 100 ml SK+F This should be used in morning water and treatment can be extended as needed. Each ml contains Sorbitol-500 mg, Sodium (Chloride)-19 mg, Magnesium (Chloride)3.045 mg, Methionine hydroxy analogue-18.25 mg, Choline (Chloride)-80 mg, L-Carnitine-25 mg, Betaine (HCl)-30 mg & Vitamin PP (B3)-2 mg. Each Litre contain, Choline chloride: 0.5 gm, Sorbitol: 5 gm, L-Lysine: 10 gm, DL-methionine-10 gm Elemnetal copper-100 mg Herbal extract- q.s to 1 litre DO 1 ml/Liter drinking water for 3-5 days. Betain HCl: 60 gm, Acetyl methionine: 100 gm, Choline chloride: 75 gm, D-Sorbitol: 350 gm, L-Lysine: 20 gm, Herb extract: q. s. to 1 liter Per litter solution contains, DL-methionione-50 g, Colin chloride-190 g, Innositol- 2.5 g, Biotin- 0.25 mg, D-panthenol-11 g, Vit-B12-10 mg, Vit-B2-200 mg. Do Do not exceed an administration longer than 10 days. 1-2 ml/litter drinking of drinking water for 5-7. ACI 240 Liq. Hepaton Vitamins, Pro-vitamin & Substances, Amino acids & their salts Poultry: 1 ml in 1-2 Ltr. of drinking water for 5-7 days. Liq. Toxol Choline, Methionine, Inositol, Vitamin B12 in a base fortified with predigested protein, Aminonitrogen (Lipoacceptor Protein) and Liver extract. Choline chloride + DLmethionine + L-lysine + Inositol + Vitamin B12+ Biotin + Vitamin E + Sorbitol + Liver fraction II + Yeast extract + Herbal extract Q.S. Broiler (As a liver tonic): 5 ml per 100 birds for 15-20 days. Layer (Treatment): 15-20 ml per 100 birds for 3-5 days. Chicks: 5 ml/100 birds daily for 5-7 days Growers: 10 ml/100 birds daily for 5-7 days Layers: 20 ml/100 birds daily for 5-7 days Broilers: 20 ml/100 birds daily for 5-7 days Breeders: 30 ml/100 birds daily for 5-7 days Treatment: 0.5 ml/ liter of drinking water for 5-7. Prevention: 1 ml/ liter of drinking water for 5-7. Soln. Livaplex Soln. Restoliv Pulv. Toxol (Liver Tonic: Nonnutritional Feed Additives) Each ml contains , Carnitine HCl- 25 mg DL-methionine- 10 mg Choline chloride- 18.75 mg Magnesium sulphate-10 mg Sorbitol (E420)- 200 mg Cynarine (antichoke extract)5 mg Carriers and preservativesQS Choline, Methionine, Inositol, Vitamin B12 in a base fortified with predigested protein and Aminonitrogen (Lipoacceptor Protein). Broiler: 1 kg/Ton of feed for 3 weeks. This will be reduced to 600 gm/Ton of feed upto end. Layer: 1 kg/Ton of feed up to 10 weeks. When laying starts it will be reduced to 700 gm/Ton of feed. After 40 weeks again 1 kg/Ton of feed. 100 ml, 500 ml, 1 Ltr 25 Ltr. 100 ml & 1 Liter plastic bottle. AlMadina 100 ml, 500 ml, 1 L POPULAR Square OPSONIN Do 1 Kg 20 Kg Square Pack size Company Hepatorenal preparations Indication: ✓ Depressed feed intake ✓ Liver & kidney dysfunction ✓ During production slumps ✓ During convalescence period ✓ Fatty changes, hepatitis and nephritis due to noxious metabolites. ✓ Any stress leading to low weight gain. Trade name Composition Trade dose 241 Liq. Digestim (Natuaral Liver & Kidney Tonic) Soln. Urinex (Renal traffic controller) Soln. Lumix (kidney tonic) Each 20 ml Liquid containsVishamusti (Extract Nuxvomica): 20 mg Bhringaraj (Extract Eclipta erecta): 25 mg Ela (Cardamom Powder): 25 mg Twak (Cinnamon Powder) : 10 mg Methica (Fennel Powder): 10 mg Peppermint Oil, Extract of Milk & etc. Each ml containCommon nettle extract-100 mg, brick extract-100 mg, horse tail extract-100 mg, potassium citrate-20 mg, Na citrate-35 mg, Ammonium propionate-50 mg Vitamin cCitric Acid Halite, Salmiac, Glucitol, Citrosodine, Alpha propylene. Should be given for 57 days by mixing with drinking water. 100 ml, 1L Square For prevention-1 ml/2 L water BID 3-5 days. For treatment-1 ml/L water BID 3-5 days. 100 ml, 500 ml Opsonin 1 ml/1-2 L drinking water 100 ml, 500 ml SK+F Chicks: 5 ml/100 birds Broiler & grower: 20 ml/100 birds. Layer: 25-30 ml/100 birds. Large animal: 50 ml/2 times daily. Antiseptics & Disinfectants Uses: For use in controlling microbial contamination in animal production facilities and farm equipment such as poultry and turkey houses, swine housing and farrowing areas. Barns and large animal buildings, hatcheries, setters, and chick processing facilities, cages and transport vehicles, and hatching eggs and for sanitizing industrial or non-food contact surfaces such as equipment for mixing, packing or packaging products, products transfer lines, storage tanks, floors and walls and for use by manufacturers and formulators in formulating products for animal housing and industrial sanitizing applications. Trade name Composition Trade Dose Pack size Company Soln. Virucide 2 quaternary NH3; NH4CL: Spray: 3 ml/1 L 100 ml, 1 ACI 170.6 gm\L, Foot bath: 12 ml/1 L L, (Buffering Glutaraldehyde: 107.25 g Water: 1 ml/5 L 20 L agent & /L, Stabilizer) Isopropanol: 146.25 g/L, Pine oil: 20 g/L, Soln. GLUTEX GQ1 (Disinfectant & Sanitizer) Glutaraldehyde- 14.0% Alkyl (C14 50%, C12 40%, C16 10%) dimethyl benzyl ammonium chloride- 2.5% Inert Ingredients- 83.5% Prepare a solution by mixing 0.45 to 1.8 fluid ounces per gallon of water (3.5 to 14.1 milliliters per liter), then thoroughly saturate all surfaces using a mop or by spraying with a solution prepared. 100 ml, 1L, 1 gallon Square 242 Liq. FAM 30 Liq. GPC-8 (Disinfectant) Soln. Povidon Vet Iodin, Non Ionic Surfectant, Sulfuric Acid, Phosphoric Acid Gluteraldehyde-25.483%, Quarternary ammonium9.686%, Non-ionic surfactant 7.995%, Phosphoric acid- 1.081% Povidon Iodine 10% USP Solution Liq. Timsen N-alkyl Dimethyl benzyl Ammonium Chloride Soln. Bioclean plus Glutaraldehyde: 15% Benzyl conium: 10% Soln. Povin Povidine iodine 10% Spray: Mix 5.5 ml/L, then spray Spray: Mix 5 ml/L, then spray. Farm, utensils, equipment’s & footbath: 7 mL/liter water Ruminant and Poultry: Spray: 1 gm/L water Idw: 1 gm/16 L water Apply directly on affected body area Regular sterilizationDilute 2.5 ml with 1 liter water and spray 300 ml/m2 area. Footpath-Dilute 10 ml with 1 liter water. Fogging-Mix 7 ml with 1 liter water and fogging 100 m3 area. Shed waterer, feeder, Litter, fodder area: 5 ml/L Foot bath, Utensils: 10 ml/L Wound: 10 ml/L 100 ml, 1L, 5 L, 25 L DO Renata 100 mL, 500 mL 1L 1 gallons, 5 gallons SK+F 100 ml, 1 L Chemist 100 ml, 500 ml, 1L Opsonin Renata EON 243 Rabbit medicine Certain antibiotics (e.g. clindamycin, lincomycin, Neomycin, Spectinomycin, Spiramycin, Tilmicosin, Vancomycin, ampicillin, amoxicillin, amoxicillin-clavulanate, cephalosporins, many penicillins, and erythromycin) can alter large bowel ecology, threaten favorable microorganisms, and promote bacterial pathogen growth (e.g., E coli and Clostridium) and toxin production. The resulting bacterial dysbiosis can lead to enteritis, enterotoxemia, and gastrointestinal (GI) stasis. Severe cases can be life-threatening. Antibiotic-associated dysbiosis may be avoided by using only appropriate broadspectrum antibiotics (e.g., trimethoprim-sulfas, fluoroquinolones, chloramphenicol, aminoglycosides, azithromycin, and metronidazole). Oral antibiotics are more likely to cause dysbiosis in rabbits than are injectable antibiotics. Good example: oral penicillins are strictly contraindicated in rabbits, but procaine + benzathine penicillin combination is safe and effective (especially for anaerobes/odontogenic abscesses) when administered as a subcutaneous (SC) injection. (https://www.vetfolio.com/learn/article/rabbit-therapeutics-whats-safe-effective-or-deadly) 244 Disclaimer: There are very few products that are licensed for use in rabbits. The responsibility for the use of unlicensed products lies with the prescribing veterinary surgeon. The following dose rates are based on the current state of knowledge and some dose rates are anecdotal. Preparation Type of drug Dosage Route Frequency Comments or Indication Acepromazine Sedation 0.5–1 mg/kg IM, SC Not analgesic. Acepromazine Sedation 0.5 mg/kg IM, SC Can be mixed in + Butorphanol + same syringe 0.5 mg/kg Vasodilatory. Albendazole Anthelmintic 20 mg/kg PO Daily Used to treat E. cuniculi, Continue for 3–14 days. Amprolium Anticoccidial 1 mL/7 kg BW PO once daily Prolonged high for 5 days. dosages may cause (Using 9.6% thiamine solution) deficiency; treatment is usually no longer than 14 days. Aspirin Analgesic 100 mg/kg PO First aid pain relief. Atropine Premedication, 0.05 mg/kg IM 40% rabbits Organophoshate (50 μg/kg) produce toxicity atropinesterase that metabolizes atropine. Azithromycin Staphylococcus osteomyelitis- 50 PO once daily mg/kg. Jaw abscesses- 15–30 mg/kg. Betamethasone Glucocorticoid 0.1 mg/kg IV Buserelin FSH/LH 0.2 ml/rabbit SC Used to induce (Receptal, ovulation and Hoechst) improve conception rate in breeding does. Carprofen Analgesic 2–4 mg/kg sid SC Care in hypotensive 1.5 mg/kg bid PO patients Tablets can be mixed with fruit juice, jam or syrup. Cephalexin Staphylococcal 15 mg/kg SC bid infections. 20 mg/kg SC sid Cholestyramine Ion exchange 0.5 g/kg, PO bid Enterotoxaemia resin 2 g/20 ml or Can be used water sid prophylactically Chlorphenamine Antihistamine 200–400 μ/kg PO bid Paediatric syrup maleate available 245 Preparation Chlorpromazine Chlortetracycline Type of drug or Indication Tranquillizer, anti-emetic mycoplasma, spirochetes, Chlamydia, Rickettsia. Gram-(+) & gram-(+) Dosage Route Frequency 3-5 mg/kg 50 mg/kg IV IM PO q12–24h Comments Antibiotic. High calcium, magnesium or iron supplemented diets may inhibit the absorption of this drug. Hindered absorption, when concurrent administration of antacids. Product withdrawn Contact manufacturers Used to treat labyrinthine disorders in humans Ciprofloxacin treating pasteurellosis 5–20 mg/kg PO q12h Cisapride Prokinetic 0.5 mg/kg PO bid Cyclizine Torticollis 8 mg/ rabbit PO Bid Dexamethasone Antiinflammatory Sedation Respiratory stimulant For mycoplasmal pneumonia Antibiotic 1–2 mg/kg IM, IV 1–2 mg/kg 5 mg/kg IM, IV IM, IV 2.5–5 mg/kg PO q12h 5–10 mg/kg, 200 mg/L DW, 20 mg/kg 0.2–0.3 ml/kg SC PO bid sid PO IM, SC daily 10–20 ml/kg/hour, 10–15 ml/kg 1.1 mg/kg for 5 doses Can be used in combination with midazolam or diazepam (0.5–2 mg/kg) Warm before use SC Bid Care in hypotensive patients 0.3–2 mg/kg IV,SC, IM Diazepam Doxapram Doxycycline Enrofloxacin Fenbendazole Fentanyl/fluanisone Anthelmintic Premedication, Analgesia, Anaesthesia. Fluid therapy: intravenous subcutaneous Flunixin Analgesia Furosemide Diuretic Not analgesic Do not use in young or pregnant animals. Licensed for use in rabbits 246 Preparation Type of drug or Indication Fusidic acid: eye drops for Conjunctivitis, Ointment for Superficial pyoderma Gentamicin Conjunctivitis Gentamicin effective against gramnegative organisms. Glucose Anorexia 5% Perioperatively Glycopyrrolate Premedication OP poisoning Dosage Route Comments 1 drop/eye, Topical sid or bid 1–2 drops/eye 5–8 mg/kg If given IV, dilute into 4 mL/kg of saline and give over 20 minutes 10 ml/kg tid Give for 5–7 days daily May induce acute renal failure. SC, IM or IV. IV, SC 0.01 mg/kg 0.1 mg/kg IV SC, IM Griseofulvin Ringworm 25 mg/kg PO Imidacloprid Fleas 10 mg/kg Topical Ivermectin Ketoprofen Mites Analgesia 400 μg/kg 1–3 mg/kg SC PO Ketamine Dissociative general anesthetic; also inhibits NMDAreceptors so may be adjunctively useful to control pain for induction Alone: 20–60 mg/kg, IM, IV. Alone: 20–50 mg/kg IM or 15–20 mg/kg IV Ketamine and Diazepam Frequency Warm before use Does not cross blood–brain barrier and cause mydriasis sid Continue for at least 2 weeks Active against fleas not mites Repeat after 10–14 days Bid Care in hypotensive patients Irritant by IM route. Must be diluted and injected with care to avoid the sciatic nerve. Diazepam 5–10 mg/kg IM, give ketamine 30 minutes after diazepam at 20–40 mg/kg IM or Diazepam 0.2–0.5 mg/kg and Ketamine 10– 15 mg/kg (to effect) IV. Not recommended for pet rabbits. Ketamine and Xylazine Liquid paraffin for induction Gastric or impactions 1–2 ml/kg PO Bid Meloxicam Analgesia 0.1–0.2 mg/kg PO Sid Can be used to soften and lubricate caecal/intestinal contents Palatable 247 Preparation Metoclopramide Metronidazole Nandrolone Oxytetracycline Oxytocin Penicillin (Procaine) Penicillin Procaine + Benzathine Penicillin Penicillamine Piperazine citrate Praziquantel Prednisolone Prochloperazine Type of drug or Indication Motility stimulant, Anti-emetic, Dosage Route Frequency Comments 0.5 mg/kg SC, PO Bid Antibiotic, antiprotozoal Anabolic steroid 20 mg/kg Po Bid 2 mg/kg SC, IM May not be effective in young rabbits. Used to treat gastric trichobezoars in rabbits. Treatment of choice for enterotoxaemia Appetite stimulant Adjunct to treatment for anaemia especially in CRF Antibiotic 15 mg/kg 30 mg/kg (depot) 1 mg/ml 50 mg/kg 1–2 IU/kg SC,IM SC Induction of parturition and milk let down Antibiotic Antibiotic Chelating agent Antiparasitic (ascarids) For treatment of cestodes Antiinflammatory Torticollis sid every 3d DW PO SC, IM 40 000 IU/kg (40 mg/kg) 20 mg/kg PP + 15 mg BP/kg SC Sid Contain 1 000 IU/mg SC wkly Treatment of choice for Treponema cuniculi Give 3 weekly injections 30 mg/kg PO Bid Copper and lead toxicity For Pinworms: Piperazine citrate 100 mg/kg PO q24h for 2 days. Piperazine adipate: Adults: 200–500 mg/kg PO q24h for 2 days. Young rabbits: 750 mg/kg, PO once daily for 2 days. Wash the perianal area. 6 mg/kg SC Repeat after 10 days 0.5–2 mg/kg 0.2–0.5 mg/kg PO,IM, SC PO Tid sid bid Ranitidine Gastric ulceration 2 mg/kg 2–5 mg/kg IV PO Sulphadimidine Coccidiosis 100–233 mg/l DW Doses as high as 30 mg/kg tid are used to treat labyrinthine disorders in humans Gastric ulcers often occur in inappetant rabbits 248 Preparation Trimethoprim/ sulphadiazine Trimethoprim/ sulfamethoxazole Tetracycline Toltrazuril Tylosin Verapamil Type of drug or Indication Antibiotic Antibiotic, Coccidiosis Antibiotic. For tyzzers disease, pasteurellosis, mycoplasmosis, Gram-(+) & gram-(+) Coccidiosis Antibiotic To prevent postsurgical adhesions Dosage Route Frequency 30 mg/kg 48 mg/kg 40 mg/kg PO SC PO Bid 50–100 mg/kg PO q8–12h Bid 25 ppm by DW, 25 mg/kg by PO. Give daily for 2 Days. Repeat after 5 days. 10 mg/kg SC, IM bid 200 μg/kg SC tds Comments ‘Co-trimoxazole’ human formulation available as paediatric syrup Continue for 7 days Can be used for treatment of rabbit colonies Start immediately postop then eight hourly for doses. Not used routinely. (Human trade & veterinary trade are available. Follow trade of Farm animal medicine, Pet animal medicine, Poultry medicine, DIMS & DIMS VET app. Calculate by ownself) ✓ Rabbits drink approximately 10% of their bodyweight daily and eat approximately 5%. Abbreviations: sid: once daily; bid: twice daily; tid: three times daily; wkly: once weekly; IV: intravenous injection; SC: subcutaneous injection; IM: intramuscular injection; PO: by mouth; DW: in drinking water. Reference for above drug’s chart: Textbook of Rabbit Medicine by Frances Harcourt-Brown & Plumb’s Veterinary Drug Handbook- 7th Edition. 249 Fish Medicine Antibiotics and Antimicrobials Amino-penicillin: Amoxicillin Specific Indication on Fish: Fin rot disease, tail rot disease, dropsy, white & red spot disease and gill disease. Trade name Composition Trade Dose Pack size Company Pulv. Amoxivet Amoxycillin Trihydrate Fish & Shrimp: 80 mg/kg 100 gm, Techno : 30 gm/100 gm body weight daily. 500 gm Pulv. Moxillin Vet Do Fish & Shrimp: 4-5 g/kg 100 gm, Acme DS feed daily for 5-7 days. 500 gm Pulv. Moxacil-Vet Do Fish & Shrimp : 50-60 mg 100 gm Square / kg fish for 5-7 days. 500 gm container Quinolone Ciprofloxacin Indications : Ciprofloxacin is indicated for bacterial (Aeromonas sp. & Pseudomonas sp.) disease of catfish such as stinging catfish, walking catfish etc. Trade name Composition Trade Dose Pack size Company Bol. Proxacin Each bolus contains 1 bolus/ 20-40 kg feed 1 gm Bridge Ciprofloxacin BP 1 gm. for 10 days. bolus Bol. Cipro-A Vet Do 1-2 bolus/ kg feed for Do Acme 5-7 days. For Aquaculture pond: 5-7 bolus/ decimal (3 feet depth of water) for 3-4 days. Pefloxacin Fish & Shrimp: Pefloxacin is indicated for the disease of fish & shrimp such as Aromonus, Septicemia, Furunculosis, Columnaria, Vivriosis, Bacterial Gill etc. Trade name Composition Trade Dose Pack size Company Pulv: Peflox Each 10 g powder Fish & Shrimp: 1 g/20 kg 10 gm Acme vet contains Pefloxacin body weight for 3-5 days. 100 gm Mesylate Dihydrate BP equivalent to 1 gm Pefloxacin. Aminoglycosides Neomycin Description: Neomycin Sulfate is a broad-spectrum antibiotic of the aminoglycoside class. Effective against: Open Sores, Internal Swelling, Loss of Color, Body Distortion, Body and Fin Rot, Bacterial Infections, Guppy Disease, Furunculosis. Trade name Composition Trade dose Pack size Company Pulv. Neoxel Each gm powder Fish/Shrimp: In feed, 2 gm per 10 gm SK+F vet contains Neomycin 20 kg feed. 100 gm, 500 gm, 250 Pulv. Neovet Sulphate USP 500 mg. Each gm powder contains Neomycin Sulphate USP 700 mg. 1 kg Do 100 gm, 500 gm, Techno Tetracycline Oxytetracycline Description: It has been proven highly effective in controlling diseases caused by Gram-positive and Gram-negative organisms that adversely affect salmonids, catfish and lobsters. ✓ In catfish for the control of bacterial hemorrhagic septicemia, and pseudomonas disease. ✓ In Salmonids for the control of ulcer disease, furunculosism bacterial hemorrhagic septicemia, and pseudomonas disease; ✓ In freshwater Salmonids for the control of cold water disease; ✓ In freshwater-reared Oncorhynchus mykiss for the control of columnaris disease; ✓ In treating Pacific Salmon for skeletal marking. ✓ In lobster it is used for the control of gaffkemia. Trade name Composition Trade Dose Pack size Company Bol. Livet Each Bolus contains General Dosage: 5-7 1 gm Bridge Oxytetracycline BP 1 gm. bolus per 100 kg fish. bolus Bol. Tetravet Each bolus contains Fish- 75 mg/kg body 500 mg Renata Oxytetracycline (as weight for 5-10 days. bolus Oxytetracycline Shrimp- 450 mg/kg Hydrochloride BP) 500 body weight once mg daily. Pulv. TetravetEach gram contains Fish 100 g ACME 200 WSP Oxytetracycline (as for prevention: 3-4 1 kg Hydrochloride) BP 200 g/kg feed sachet mg. for treatment: 4-6 g/kg feed; Shrimp for prevention: 4-6 g/kg feed for treatment: 8-10 g/kg feed for 5-7 days. Sulfur drugs + Erythromycin Indications: is effective in case of gram-positive cocci infection of fish. Trade name Composition Trade Dose Pulv. EROTIN Each gm powder contains Fish: 1 g/10 kg body (Vet) Erythromycin thiocyanate weight for 3-5 days. INN-180 mg Sulphadiazine USP-150 mg Trimethoprim USP-30 mg Pulv. Eraprim Vet Do Do Pulv. ETS Vet Do Do Pack size 10 gm Company Albion Do 100 gm Acme Bridge Pack size Company Natural Coccidiostat Trade name Composition Trade Dose 251 Pulv. Herb-Al COCC-X Natural compound Aquaculture: up to 2 kg/MT of feed depending on species 20 kg Bag and 500g container Square Pack size Company 15 mL, 100 mL & 500 mL SK+F Ivermectin Indications: acts against following endo and ecto parasites: Endo-parasites: Round worm Ecto-parasites: Tick, Lice, Mite, Flea Trade name Composition Trade Dose Each ml solution Pond: 1 mL/ decimal (per feet contains depth of water) Soln. Verkil vet Ivermectin BP 10 mg Ammonia reduction Trade name Pulv. ACME’S ZEOLITE Vet Composition Trade Dose Pack size 10 kg Company Aluminium Sodium During Pond Preparation: Acme Silicate Old Pond: 20-25 kg/Acre Composition: New Pond : 15-20 kg/acre (ammonia SiO2-65% During Culture Period: reduction) Al2O3--13% Depth Dosage CaO--4% 3-4 ft 10-15 kg/acre MgO--2% 5-7 ft 20-25 kg/acre Na2O--1% Above 7 ft 30-35 kg/acre K2O--2% Fe2O3--1% ACME’S ZEOLITE indications: ✓ Reduce toxic gases like ammonia, hydrogen sulphide, nitrites, sulphur dioxides etc from pond. ✓ Removes off flavors from pond water and bottom ✓ Improves water quality by minimizing the production of pollutant ✓ Maintain Optimum pH Level Pulv. Freeze dried biological Pond preparation: 3 bags (300 11 kg ACI PondToss formula of natural gm)/acre bucket microbes, enzymes, During cultivation: 2 bags (220 micronutrients and gm)/acre every 15 days apart amino acids Hatchery & Nursery: 1-2 gm/ton water PondToss™ combines the best probiotic and water conditioning bacteria in one formula. PondToss™ creates improved water quality beneficial to health and growth. PondToss™ produces small peptides that have a probiotic effect on fish, improving survival. PondToss™ creates a natural, beneficial Bio-Floc, while reducing ammonia, nitrite and nitrate. PondToss™ digests organic solids and bottom sludge. Pulv. Contains Amino acids + Do Do Do ShrimpShield Probiotics + Enzymes + Yeast + Nutrients Pulv. Oxy-A Sodium Percarbonate Immediately after mixing with 1 Kg Acme water, sprinkle evenly over the pond. 252 For 3-6 feet depth of water: In general Oxygen Deficiency: 300-400 g/acre In acute Oxygen deficiency: 500700 g/acre For live fish transportation and marketing: 1-2 g/ 6 liter water For fish fry transportation: For short distance: 1 tablet/ 2 liter water For long distance: 1 tablet/ 1 liter water Tab. Oxyfil Sodium percarbonateDuring pond preparation: 100 250 1 gm 150 g per 33 Decimal for 3-5 Feet gm of Water. 500 During culture period: Normal gm Situation: 250 - 500 g per 100 Decimal for 3-5 Feet of Water. Critical Situation: 500 - 750 g per 100 Decimal for 3-5 Feet of Water. Harvested Fish Transportation: 5-6 Tablet per 100 Liter of Water 3-4 hours. Tab. Oxy Aqua Sodium Percarbonate For 3 - 6 feet deep pond 1 kg (2Na2CO3 3H2O2) General dose: 250 - 500 gm per Tablet acre Critical situation: 500 - 600 gm per acre Tab. Oxy Aqua-- A quick dissolve oxygen reliever for aquaculture. Indications: ✓ Increases dissolve oxygen in pond water ✓ Long time sustained released of oxygen (13 ±1) % ✓ Reduces mortality due to oxygen deficiency ✓ Improves water quality and easy to use ✓ Environment friendly ✓ Potential water sanitizer Pulv. Oxyren Do Do 1 kg (Sustained release oxygen 13%) Pulv. Gas Free Yucca Schidigera 100 Aqua gm Liq. Do 500 ml PondKleen Pulv. Renu Different types of According to body weight of fry. 1 kg Gold essential amino acids, See leaflet. phosphorus, calcium, (Enriched with zinc, copper, cobalt, all Probiotics) kinds of essential vitamins and minerals, Popular Navana Renata Renata ACI ACI 253 Liq. Ammocure Vet betaine, enzymes, ascorbic acid, folic acid, pantothenic acid, natural growth promoters etc. Each ml contains extract of Yucca Schidigera 500 mg. Fish and Shrimp: 2-3 ml/ decimal 100 ml Acme pond of 3-4 feet depth. Repeat after 2 to 3 weeks. Feed: 1-2 ml/ kg feed Pulv. AQUA contains hydrated During pond preparation: 105 Kg PURE sodium alumino silicate 16Kg per Acre; at 3-6 ft water PP with natural adsorbing depth Woven (Deodorizer) and deodorizing agent, During Pond management: 8Bag Square having the fastest 10Kg per Acre; at 3-6 ft water mode of action depth through highest CEC Administration: Mix with pond water and broadcast throughout the pond homogenously Pulv. Aqua SiO2: 60-65%, During pond preparation: 10 5 Kg Square Rock Al2O3: 18-22%, Kg/Acre; at 3-6 feet water depth bag Fe2O3: 2-3%, During pond management: 8-10 (Deodorizer) CaO: 15-18%, Kg/Acre; at 3-6 feet water depth MgO: 2-5% and Administration: Broadcast Na2O: 1-2% directly to the pond. Benefits: Removes toxic gases like NH3, H2S, NO2 & CH4 etc from pond water, Deodorizes the bad odor from the culture pond, Ensures healthy aquatic environment , Increases the overall productivity of pond. Control Unwanted Fish Indications: To control predator and unwanted fish. Trade name Composition Pulv. Rota Plus Rotenone-9 % Pulv. Tea Seed Meal Saponin-15-18% Trade Dose ২০-৩০ গ্রাম প্রহত্ শত্াংটশ প্রহত্ ফুে াহনর জনয ৬০০-১২০০ গ্রাম প্রহত্ শত্াংটশ প্রহত্ হমোর াহনর জনয সূযাটলাটকর ম উ হস্থহত্টত্ াহনটত্ হেক্সজটয় ভরটখ ভরাটির মট য প্রটয়াগ করটত্ িটব । Pack size 1 kg Company 10 kg ACI Pack size 25 kg bag Company Do Navana ACI Control pH of water Trade name Composition Trade Dose Pulv. Zeo Fresh Zeolite Pulv. Nava Zeolite Granular Do For Pond Preparation: 24 Kg/Acre During culture period: 10 Kg/Acre Highly polluted: 20 Kg/Acre Do Square Nutritional products Aqua Probiotics Benefits: 254 • Enhances degradation of organic wastes • Prevents black soil formation • Prevents formation of noxious gases like hydrogen sulphide, ammonia, nitrite etc • Increases the production of beneficial bacteria • Inhibits the growth of harmful bacteria e.g. Vibrio spp. • Compatible with fresh & marine water • Able to work in rainy season & cloudy conditions • Biotechnological product • No residual effect Trade name Composition Trade Dose Pack size Company Liq. ProbioA combination of During Pond Preparation: 1-2 1 Liter Square Aqua LQ Rhodopseudomonas Lit/Acre/3 feet water depth Container. palustris During Culture Period : 2-3 (Photosynthetic Lit/Acre/3 feet water depth Or, bacteria) and some as advised by an aquaculture basic mediums. consultant. Method of Application: To get the best result mix 1 Lit ProbioAqua LQ with 0.5 Kg molasses with the sufficient pond water and stay 5-6 hours before application. Liq. Protox Rhodopseudomonas During pond prevention: 1-2 Do Square Aqua palustris and L/Acre/3 ft depth Rhodobactor During pond management: 2-3 capsulatus (1.2 × 109 L/Acre/3 ft depth cfu/ml), Bacillus spp. (2 Administration: Mixing with × 109 cfu/ml) coarse sand or Aqua Rock/ZeoFresh and broadcast directly to the pond. Pulv. Maximum consortium During Pond Preparation: 3-4 1 Kg Square Biomax of probiotics bio-fixed Kg/Acre/3 feet water depth Sachet Power on a calcareous matrix. During Culture Period : 4-5 Kg/Acre/3 feet water depth Method of Application: Mix with dry, coarse sand and broadcast directly to the pond to get the best result. Pulv. Each 500 gm Gastrap® 200 gm Gastrap® Powder per 100 gm Square Gastrap Powder contains: acre of culture pond by mixing container. Lactic acid bacilluswith coarse sand or Zeo-Fresh® 30,000 million CFU and broadcast directly to the Bacillus subtillis-3,000 pond. (Probiotics million CFU + Enzyme) Saccharomyces cereviceae--25,000 million CFU Xylanase: 8,000 IU Amylase: 30,000 IU Protease: 75,000 IU Cellulase: 5,500 IU 255 Pulv. NavioPlus Hemicellulase: 24,000 IU Phytase: 45,000 FTU Betaglucanase : 4, 00,000 IU Lipase: 30,000 IU Aminonitrogen in a fortified base Benefitsq.s. Bacillus subtillis, Bacillus lichenifomis, Lactobacillus acidophilis, Lactobacillus plantarum & (Sacharomyces cerevisiae) ইস্ট shrimp and fish : 4-5 grams per 1 kilogram of feed. 500 gram per bag. ACI ভপ্রাবাটয়াষ্টেকস: 1x10^9 5 kg bag ACI পুর্ুর প্রস্তুছতলত: ১০-১২ ভকক্সজ CFU/kg (Bacillus subtilis, প্রহত্ একটর ৩ ফুে গেীরত্ার জনয Bacillus lichenformis, চাষর্ােীি সমলয়: ৭-৮ ভকক্সজ Nitrosomonas, Nitrobactor, প্রহত্ একটর ৩ ফুে গেীরত্ার জনয Rhodococcus,) ক্সজওলাইে: SiO2-60-65%, Al2O3-18-22%, Fe2O3-1-2%, CaO 15-18%, MgO 2-5%, Na2O 1-2%, ইউকা: Yucca schidigera নামক গাটছর হনযাস ম যা Saponin এর উৎস | Pond Life:- ব্যব্হার ক্ষেত্র: িাইটরাটজন সালফাইি, এটমাহনয়া, হমটথন ইত্যাহি ক্ষহত্কর গযাস িূর কটর, ুকুর ও ভঘটরর ত্লটিটশর যাবত্ীয় তজব বজময ভশা ন কটর, ুকুর ও ভঘটর ক্ষহত্কর জীবািুসমূটির বৃক্সে বযািত্ কটর, াহনটত্ দ্রবীেূ ত্ অক্সিটজন এর হরমান বাডায়, প্ল্যাঙ্কেন উৎ ািটন সিায়ত্া কটর যা মাছ ও হচংহডর দ্রুত্ বৃক্সে হনক্সিত্ কটর | ভপ্রাবাটয়াষ্টেকস: 1x10 ^9 Pulv. Pond 5 kg ACI ুকুর প্রস্তুহত্র সময়: ১০-১২ ভকক্সজ CFU/kg Guard প্রহত্ একটর Bacillus subtilis , Bascillus চাষকালীন সময়: ০৭-০৮ ভকক্সজ licheniformis, Nitrosomonas প্রহত্ একটর প্রহত্ হমোর গেীরত্ার spp, Nitrobacter spp, জনয Aerobacter spp, ক্সজওলাইে, ইউকা: Yucca schidigera নামক গাটছর হনযাস ম যা Saponin এর উৎস Pulv. Pond Life Pulv. Aquastar Growout Pulv. Aquastarpond Bacillus, Enterococcus, Pedicoccus, Lactobacillus Bacillus subtilis 1.0 x109 CFU/ g, Enterococcus faecium 3.0 x109 CFU/g, Thiobacillus denitrificans 2.0 x106 CFU/ g , Fish/Shrimp: In feed, 2-3 gm per kg feed. In pond: 0.5-2 kg/hactor, q5-25 days depending on culture system and animal density. Do 100 gm Renata 500 gm 1 kg Renata 256 Pulv. Probiozyme (Probiotics & Enzymes) Pulv. Oxylife Paracoccus pantotrophus 2.0 x106 CFU/ g Each kg contains, Bacillus subtilis 1.0x108 CFU, Bacillus licheniformis 1.0x108 CFU, Lactobacillus acidophilus 1.0x104 CFU, Lactobacillus plantarum 1.0x104 CFU, Cellulase 10,00,000 Unit, Xylanase 10,00,000 Unit, Betaglucanase 5,00,000 Unit, Alpha-amylase 15,00,000 Unit, Protease 10,000 Unit, Phytase 25,000 Unit Oxygen Precursors, Probiotics, Prebiotics and Detoxificants Aquatic animal: 2-3 grams per 1 kg of feed. 10 gm Square 100 gm Usually, 500 gm/Acre in 3-6 ft 1 Kg Square depth water Container. During stress (Cloudy weather & high bacterial count: 1 Kg/Acre Usage Instructions: Mix evenly with coarse sand/water and broadcast over the pond Benefits of Oxylife: • Promotes & maintains dissolved oxygen level • Enhances decomposition and utilization of organic matters • Prevents sludge formation and reduces the population of harmful bacteria like vibrio • Reduces the adverse effect of bacterial toxins • Improves growth Pulv. MEach kg contains: For 3-5 feet depth of water 1 kg Acme Lime Probiotic (Bacillus sp.) During pond preparation: 1201%, Yeast 0.4%, 240g/decimal During culture Fermented Plants 40%, period: 20-40g/decimal Humus 20%, Molasses 10% & Dolomite 28.6%. Benefits of M-Lime: 1. Enhance natural food (plankton) & benthos, thus help to reduce the cost of feed, 2. Control pH for the optimum level, 3. Improve growth & survival rate of fish and shrimp Phytoplankton Grower Trade Name Composition Trade dose Pulv. Aquagreen G Fermented biomass of seaweed extract, enzyme precursors and micronutrients. During Pond Preparation: 4-5 Kg/Acre/3 feet water depth During Culture Period: 3-4 Kg/Acre/3 feet water depth Pack Size 1 kg Company Square 257 Or, as advised by an aquaculture consultant Method of Application: Mix with dry, coarse sand and broadcast directly to the pond. To get the best result apply at 9.00am-11.00am in the morning. Benefits: • Ensures stable plankton bloom • Helps in faster development of natural food (phytoplankton, zooplankton & benthos) • Boosts up beneficial soil microbial activity • Acts as an alternative medium of organic and inorganic fertilizer • Promotes sustainable ethical aquaculture • Increases productivity • Biotechnological product • No residual effect Di-Calcium Phosphate Benefit: মাটছর িাটডর গঠন বৃক্সে কটর ও দ্রুত্, মাটছর হমনাটরটলর ঘােহত্ ুরন কটর ও দ্রুত্ ওজন বাডায়। Trade Name Composition Trade dose Pack Size Company Pulv. ACI DCP Each 1 kg contain Fish & shrimp: 1-5 kg/ton of 1 kg, ACI Gold Ca phosphate-90%, feed 5 kg MgSO4: 2%, NaCl-6%, 10 kg ZnO: 0.02%, I2, Casin, Frocto oligosaccharide: 0.02% Trace element (Fe, Mn, I2, Cu, Zn, Co)- 1.96% মাছ, হচংডী--১ ভকক্সজ াউিার ১০০ Pulv. Super Each kg Contains 1 kg AgroVet ভকক্স জ খাটিযর সাটথ হমহশটয় DCP Di-Calcium Phosphate-900 g Magnesium Sulphate-20 g Sodium Chloride-60 g Elements (Fe, Mn, I, Cu, Zn, Co)-20 g Phospholipid Lecithin Indication in Aquaculture: ✓ Reduce fry mortality rate ✓ Reduce physical deformities ✓ Increase body weight gain ✓ Increase egg production ✓ Improve fertility & hatchability ✓ Increase immunity Trade Name Composition Pulv. LECIPHOS Lecithin 95% Trade dose Aquaculture: (g/kg) Type of feed Shrimp Fish Nursery/starter 7.5-10 5-7.5 Grower Finisher 5-7.5 5 Pack Size 100 gm Company Acme 5 3-5 258 Lysolecithin Indication in Shrimp and Fish: ✓ Improves survival rate of shrimp and fish larvae ✓ Improves growth rate of shrimp and fish ✓ Increases resistance to stress ✓ Provides a consistent source of bio-available phospholipds ✓ Add Eurolipid in fishfood, it reduces leaching of water soluble nutrients ✓ It's acts as natural antioxidant ✓ It increases the feed tastable (palatable) Trade Name Composition Trade dose Pack Size Pulv. Eurolipid Lysolecithin Fish: 50-60 g per 100 kg feed. 100 gm Company ACI Multivitamin Benefits: ✓ Supplies more nutrients and replenishes vitamin deficiency ✓ Increases survival rate ✓ Helps in the fast larval development of fish/shrimp ✓ Helps in the shrimp molting, providing healthy after molting ✓ Improves resistance towards diseases ✓ Helps Fish/shrimp larva to be more active ✓ Uses as an adjunct therapy with antibiotics ✓ Boosts immunity & reduce stress Trade Name Composition Trade dose Liq. Panvit-Aqua Each 100 ml contains: In hatchery: 0.5-1 ml/ton of Vitamin A- 500000 IU water. Vitamin D3- 100000 In nursery pond: 0.5-10 IU ml/Kg of nursery feed. Vitamin B1- 160 mg Vitamin B2- 100 mg Vitamin B6-100 mg Nicotinamide- 1 gm Calcium D Pantothenate-500 mg Ascorbic Acid- 5 gm Soln. Liquavit Each 100ml contains: মাছ ও চ িংচির ররনু ও র ানা: Vitamin A 250000 IU; ৫-১০ চমচি প্রচি রেজি Vitamin D 80000 IU; খাবারর Vitamin B1 160mg; বি মাছ/চ িংচি: ৫-১০ চমচি Vitamin B2 100 mg; প্রচি রেজি খাবারর Vitamin B6 50 mg; হ্যা াচর ও র ানা চরবহ্রন: vitamin 50 mg; ০.৫-১ চমচি প্রচি টন Vitamin C 5 gm; াচনরি Immunostimulant q. s. to 100 ml Pack size 100 ml Company Square 100 ml ACI Pack size Company Feed Premix Trade Name Composition Trade dose 259 Pulv. Bio-Surf Each 1000 gm powder Fish : 500 gm – 1 Kg per 1 Kg Square contains: Ton of Feed continue. 20 Kg. Hydrolysed Lecithins-Lyso – Phospholipids: 20 gms Phosphatidyl Choline: 33 gms Tri-methyle Glycine: 5 gms Organic Phosphorus: 7.6 gms Active Polypeptides: 10.2 gms Methyle Donars: 38 gms Gut Stabilizers: 2 gms Base: Calcium Carbonate--qs Bio-Surf Indication: For digestibility of fat and availability of energy as it acts as natural emulsifier and improves absorption of fat soluble vitamins and other nutrients. Pulv. Square Vitamin, Mineral, Amino Acid, 1 gm premix per Kg of 1 Kg Square Aquamix Prebiotics, feed or 1 Kg/MT of Feed 25 Kg Antioxidant, Yeast (Blend homogeneously with the daily feed ration Pulv. Contains 12 Enzymes, 2 For Fish: 0.5-1 g / Kg 500 g Popular Prebiotics, Antioxidant, 3 feed 1 Kg NutriFish Vitamins, 12 Minerals, 2 For Shrimp: 2-3 g / Kg Amino Acids & feed Fish Flavor For Brood Fish: 1-2 g / Kg feed Liq. Aminovit Amino Acids + Vitamins + Hatchery: 100 ml Popular Plus aqua Minerals + Dextrose Fish Larvae: 3-5 ml per 500 m 100 liter water. Shrimp Larvae: 8-10 ml per 100 liter water. Brood Fish: 4-6 ml per Kg feed. Culture Period: Catfish: 2-3 ml per Kg feed. Other Fishes: 1 ml per Kg feed Indications of Aminivt Plus aqua Aminovit Plus Aqua is a highly enriched with essential amino acids, vitamins, minerals and dextrose. These unique combination aims to optimize the growth performance, fecundity, egg maturity, hatchability, immune response, digestion and survival of fish and shrimp larvae. Pulv. Hyvit Vitamin A, D3,E,K3, B1, 1 kg per ton feed. 1 kg AlAqua WS B2,B6,B7, B9, B12, C, Madina Nicotinamide, Pentothenic Acid, Folic Acid, Manganese,Zinc, Iron, Copper, Iodine, methionine and L-lysine. Pulv. 13 Vitamins, 7 Mineral & 1 1-2 g/feed 100 g SK+F Nutrimax Antioxidant 1 kg container 260 Pulv. Biomin Aquaboost Pulv. Hepaprotect Aqua Pulv. Renafish Pulv. ESKAVIT FISH SP PREMIX Amino Acid, Natural Immunustimulator, Active Fish Attractant Flavonoids, Natural Occurring Cell Wall Each kg contains, Vitamin A- 5000000 IU, B1-1 g, B2-2 g, B6-1 g, B12-2g, D3300000 IU, E-8 g, K3-6 g, Niacinamide-10 g, D pantothenate-5 g, Folate-0.25 g, Biotin-20 mg, Vitamin C-5 g, Co-0.10 g, Cu-3 g, Fe 10 g, I0.20 g, Mn- 20 g, Calcium qs to 1000g Vitamins, minerals & calcium enriched nutrition premix 100-200 gm/100 kg feed 100 gm Renata 1-2 gm /kg fish feed 100 gm Renata 1 kg per ton fish feed. 1 kg Renata Add 2.5 kg premix per ton of feed. 25 kg shipper SK+F Liq. Hepafit aqua Each ml contains Sorbitol 500 For use in Fish/Shrimp 100 ml, Acme mg, Sodium Chloride-19 mg, Feed. 1 ml/kg feed. 500 ml Magnesium (Chloride)-3.045 1 Liter. mg, Methionine hydroxy Or, as directed by the analogue-18.25 mg, Choline Aqua Expert. (a liver tonic) (Chloride)-80 mg, L-Carnitine25 mg, Betaine (HCl)-30 mg & Vitamin PP (B3)-2 mg. Hepafit aqua is effective in fatty liver syndrome, hepatic dysfunctions, and metabolic disorders in aquaculture Pulv. Vitamin, Mineral, Amino Acid, 1 kg 1 g/ kg feed regularly. Acme VITAMIX-F Antioxidant & Anti caking AQUA agent VITAMIX-F AQUA indications: Increases growth and body weight, To ensure Feed utilization by improving Feed Conversion Ratio (FCR), Maintains better immunity & reduce mortality rate, Helps to improve reprodutive performance & Hatchability, Helps to normalize the molting of shrimp Pulv. Fishlog Poultry Meal – CP 60% (min.) (Protein Supplement) In Fish feed, 5-20 kg mixed with each 100 kg finished feed 25 Kg bag Square Fishlog Indication: To fulfil dietary requirement of protein in poultry, To ensure proper growth and production, To ensure balanced protein in feed Pulv. Fishtin Pure Fishmeal – CP 60% (min.) Up to 30% in Fish feed Do Do Pulv. Acimix Super fish চিটাচমন, চমনাররি ও এমাইরনা এচিড িম্মৃদ্ধ চিড চপ্রচমক্স ১-২.৫ রেজি প্রচি টন খাদ্য 2.5 kg ACI Pulv. Orulina Protein-60-65%, Carbohydrate-15-16%, Mineral-9-12%, For nursery pond: 10 gm per kg feed 100 g Sachet Square 261 Lipid-5-6% Pigment-8-12% For culture pond: 5 gm per kg feed Or, as recommended by aquaculture specialist. Method of Application: Mix with feed and broadcast directly to the pond. Electrolytes Vitamin C + Glucose Indications: ✓ Provides fast energy to fish fry ✓ Helps to reduce stress during transportation ✓ Increases immunity ✓ Reduces fish fry mortality Trade Name Composition Trade dose Pulv. NRG C Each gram powder For fry transport: 1-2 gm/ contains litre water Anhydrous Glucose For Big fish transport: 3-5 BP--980 mg gm/ litre water Ascorbic Acid USP--20 For Fry stock: 5 gm/ litre mg water dip bath for 5-10 mins. Pulv. Albi DO DO Glucose-C (Vet) Pulv. Eskavit C Ascorbic acid-1000 mg/gm Pulv. Cevit-Aqua Each gram powder contains L-Ascorbic Acid (Vitamin-C) 990 mg. For Fish & Shrimp In water: 2-3 gm/ton. In feed: 1-2 gm/kg feed. For de-chlorination: 1 gm Eskavit C neutralizes (1 mg of chlorine/liter of water) 380-liter water For hatchery & nursery: Prevention: 0.5 - 1 gm/ton of water. Treatment: 2 gm/ton of water. For culture farm: Prevention: 1 gm/Kg of feed. Treatment: 2-3 gm/Kg of feed. Or, as advised by an aquaculture consultant. Pack size 500 gm Company SK+F DO Albion 1 kg SK+F 100 gm Square 1 Kg container. Betaine Hydrochloride Trade Name Pulv. Betain-Vet Composition Betaine Hydrochloride Trade dose 2 – 3 kg per ton of complete feed. Pack size 500 gm Sachet, Company Square 262 25 kg bag. Indication: Enhances stress resistance, Saves methionine to cut feed costs, Regulates osmotic pressure to maintain cell water balance, Improves meat quality, Feeding stimulation Sanitizer Trade name Composition Soln. Povidon Vet Povidon Iodine 10% USP Solution Trade dose Pack size 100 mL, 500 mL 1L Company Aqua: SK+F Hatchery fry & eggs disinfection: 2-3 mL/100 liter water (10 min dip bath) Brood fish disinfection: 3-5 mL/100 liter water (10 min dip bath) Pond or Gher: 1-1.5 liter/ Acre for 3-4 ft. depth Indication: Povidon Vet Controls Viral, bacterial, fungal diseases and certain protozoan in shrimp/Fish, Poultry & Dairy. Povidon Vet deodorize and purifies pond water . Povidon vet Used as Disinfectant & to maintain Bio-security in Aquaculture, poultry & Dairy Farm ুকুর/ভঘটরেঃ ১০০ হমহল. প্রহত্ হবঘায় ৩Liq. Pathonil It contains Alkyl 100 ACI ৫ ফুে গেীরত্ার জনয ৬-৮ হলোর dimethylbenzyl ml াহনটত্ হমহশটয় হছোটত্ িটব। ammonium chloride 80% িযাচাহর ও যন্ত্র াহত্ জীবানুমুক্তকরটিেঃ ১which is also known as ২ হমহল. প্রহত্ েন াহনটত্; বযবিাটরর Benzalkonium chloride ূটব অবশযই ম ১ হমহল. ১ হলোর াহনটত্ (BKC) 80%. হমহশটয় হনটত্ িটব। অথবা মৎসয হবটশষটের রামশ অনু ম যায়ী বযবিায ম Pathonil is effective in the prevention and cure of fish and shrimp diseases caused by harmful bacteria, virus, fungus, and protozoa. It also controls massive algal growth and prevents parasites like Zoothamnium. Fish and shrimp become shining due to the sanitization. Molting of shrimp is also accelerated with the help of Pathonil. It can be used for water treatment and to keep water supply and equipment hygienic. ২০০ গ্রাম প্রহত্ হবঘায় (৩৩ শত্াংশ) ৩-৬ Pulv. Virex Potassium 20 kg ACI ফুে গেীর জলাশটয়র জনয Peroxymonopersulphateিযাচাহরটত্েঃ ২-৩ গ্রাম ১ হলোর াহনটত্ 50% হমহশটয় বযবিার করটত্ িটব Sodium Dichlorisocyanurate-5% Virex ব্যব্হারলেত্রঃ খামাটর হবহেন্ন োইরাস, বযাকটেহরয়া, ফাংগাস এবং জীবািু দ্বারা সৃি ভরাগ প্রহত্টরা কটর Liq. Aquakleen Each 1000 ml contains Benzalkonium Chloride 89.6 gm & Amino nitrogen as (DLMethionine) 10000 ppm For Fish: 1 litre/1 Acre (100 1L Square decimal) 4 ft-6ft water depth each in every 15 days For shrimp: 1 litre/1 Acre 3.35 ft-6 ft water depth each in every 15 days. Mix 1 litre of Aqua-fresh liquid with 10 litre of pond water and broadcast all over the pond. Benefits of Aquakleen: Reduces excessive production of green and blue algae, Sanitizes pond water, Improves pond water quality parameter, Helps in cleaning the body and gill of shrimp and fish, Helps in molting of shrimp, Increases the brightness of fish body color, Cleans up the antenna rot, gill rot and tail rot, Facilitates feed intake 263 Hormonal drugs Estrogen (Estradiol cypionate) Mode of action: It stimulates growth and maintenance of the reproductive tract, female body configuration, bone growth and maintenance, epiphyseal plate closure, distinctive pubic hair pattern, cervical mucus secretion, breast development and function, prolactin secretion, and myometrial contractions. Indication: Retained placenta, mild postpartum hemorrhage, increased contraction uterine, metritis, pyometra, mummified fetus, induced parturition (mare), artificial induction of lactation. Generic: Dog: 44 micrograms/kg (0.044 mg/kg) IM once; during day 4 estrus to day 2 of diestrus. Cat: 250 micrograms/kg (0.25 mg/kg) IM once 6 days after coitus; or 0.25 mg/cat IM at 40 hours after coitus. Horse: 5–10 mg (total dose) IM once. Cattle: 4–20 mg, IM. Contraindication: Pregnancy, bone marrow cancer, ovarian cyst, prolapsed vagina. Trade name: No veterinary trade but Human trade available. (This drug is rarely used for this indication today as there are safer, more effective treatments.) Progesterone Indication: Prevent habitual abortion, promote conception rate, estrous synchronization, birth control pill, vaginal prolapse, tranquilizing effect and androgenic effect, artificial milk induction Generic: Dog, Cat: 1.1–2.2 mg/kg q7d, IM. Cattle: 100–200 mg for Implant. 500 mg for IM Horse: 150 mg, q24h, IM Contraindication: Pregnancy-prolonged gestation, Fetal death. Trade name Composition Dose Pack Company size HPC Hydroxy-progesterone Cattle: 2 ml ,IM 1 ml, Popular (Human) Caproate- 250 mg/ mL 2 ml GnRH (Gonadotropin-releasing Hormone) Mode of action: Act on anterior pituitary gland to release FSH and LH. It acts directly on ovary and FSH helps to develop ovarian follicle & LH helps for ovulation & leutinization. Indication: True and post partum anestrous, silent heat, follicular cyst, delayed ovulation, anovulation acyclicity, and increased fertility at the time of insemination, Improve conception rate. Generic: Gonadorelin acetateCow/Buffalo/Sheep/Goat: 250-500 mcg (total), IM/IV Dog: 50–100 mcg (total) IM, q24-48h. Cat: 25 mcg (total), IM, once. Contraindication: Pregnancy Trade name Composition Dose Pack size Company Inj. Fertilon Gonadorelin Cystic ovary, Repeat breeding & 5 ml vial Techno acetate: 100 Anoestrus cycle: 2.5-5 ml single µgm/ml dose, IM. 264 Inj. Gonarelin Vet Do Inj. Gonadon Do Inj. Fertagyl Do Inj. Ovurelin Do Inj. GODOREL Gonadorelin acetate: 50 µgm/ml Inj. Receptal Each ml contains 0.0042 mg buserelin acetate equivalent to 0.004 mg buserelin and, as antimicrobial additive, 2 % benzyl alcohol as preservative. For cystic ovarian disease: 5 ml as a single IM injection For Improvement of fertility/Improvement of conception rate/Repeat breeding: 2.5–5 ml as a single IM injection For improvement of fertility in post-partum: 1–2.5 ml as a single IM injection For the prevention of delayed ovulation: 2.5 ml as a single IM injection before insemination. Cows -Ovarian cyst: 5 ml (500 ㎍) IM. -Stimulate Ovulation: 2.5 ml (250 ㎍) , IM. Sows -1ml (100㎍) 2~3 hours before insemination, IM. Cow: 5 ml, IM Rabbit: 0.2 ml ,IM Cow: For intramuscular injection to the anterior half of the neck. -Oestrus synchronisation: 1 ml (100 µgm) -Prevention of delayed ovulation: 2.5 mL (250 µgm) -Improvement of postpartum fertility: 2.5 mL (250 µgm ) -Cystic ovaries: 5 mL (500 µgm) IM injection Treatment of anoestrus on the first day: 2 ml On the seventh day: 3 ml On the ninth day: 2 ml Cattle: IM/IV/SC -For the treatment of follicular cysts with or without symptoms of nymphomania: 20 μg (5 ml) / animal. -For improvement of conception rate: 10 μg (2.5 ml) / animal. - For synchronization of oestrus and ovulation before fixed time AI: 10 μg (2.5ml) / animal. Do Bengal 10 ml 20 ml Wilts marketing 20 ml 100 ml 20 ml, 100 ml Intervet 10 ml ACI 2.5 ml, 5 ml, 10 ml 50 ml Intervet Renata Prostaglandin Mode of action: Lysis of corpus leutium, decrease progesterone level and increase estrogen level. 265 Indication: Estrous synchronization, Induction of parturition, abortion, Pyometra, Mummified fetus, Anestrus due to persistence of CL, Incomplete dilatation of cervix, Luteal cyst treatment, metritis, routine use in early post partum period for uterine involution. Generic: Two typesCloprostenol: Dog: 1–5 mcg/kg q24h, SC. Horse: 100 mcg/horse, IM. Cattle: 500 mcg/cattle, IM Swine: 175 mcg, IM Sheep, Goat: 62.5–125 mcg, IM. Dinoprost tromethamine: Dog, cat: 0.1–0.25 mg/kg q24h, SC. Horse: 1 mg/45 kg, IM. Cattle: 25–30 mg, IM. Swine: 5–25 mg, IM Sheep, goat: 2.5–20 mg, IM. Contraindication: Pregnant, BCS>2, Do not administer i/v, readily absorb with skin so after use hands should be washed with soap. Trade name Composition Dose Pack Company size Inj. Lutalyse Dinoprost Cow- 5ml (25 mg) IM 30 ml Zoetis tromethamine: 5 mg/ 100 ml (Imported ml by Techno) Inj: Reprolyse Do Ruminant: 10 ml ACI 3 ml, IM for 350 kg bw. 4 ml, IM for above 350 kg bw. Inj. Ovuprost Cloprostenol sodium: IM in the anterior half of the 20 ml Renata 250 µgm/ml neck. Cows: 2 mL Mares: Up to 400 kg bodyweight0.5 – 1 mL Over 400 kg bodyweight: 1-2 mL Sows: Single dose of 0.7mL, within 3 days of expected farrowing date. Inj. Prostenol Do Do 2 ml Techno Inj. Remeprost Do Do Do Bengal Vet Inj. Dinorin Cloprostenol sodium: Cow- 500 µgm/5ml, IM 10 ml Dong 100 µgm/ml Pig- 175 µgm/1.75ml, IM 30 ml Bang Co. Ltd. FSH (Follicle-stimulating hormone) Mode of action: FSH helps to develop ovarian follicles. Indication: Induce super ovulation for embryo transfer, induce estrus in anestrus animal. Contraindication: Pregnancy 266 Trade name Inj. Folligon Composition Pregnant Mare Serum Gonadotrophin (PMSG): 1000 IU/ml Dose Pack size Company -Anoestrus in the cow & buffaloes: 500-1000 IU by I/M route. -Super ovulation (required for embryo transplantation) in the cow: 1500-3000 IU by I/M route between day 8-13 of cycle. -Increase of fertility rate after progesterone pre-treatment: 300-750 IU by I/m route at the end of a progesterone treatment. 5 ml Intervet (1 vial with solvent for reconstitution.) LH (Luteinizing hormone) Mode of action: LH helps for ovulation & leutinization Indication: COD, nymphomania, delayed ovulation, anovulation, diagnosis for the presence of testicle (Rig test) Generic dose of human chorionic gonadotropin (hcg): Dog: 500–1000 IU, repeat in 48h, IM. Cat: 100–500 IU, IM. Horse: 1,000–5,000 IU, IV. Cattle: 2500–5000 IU, IV or 10,000 IU, IM. Sheep, goat: 250–1,000 IU IV/IM. Swine: 200 IU, IM Contraindication: Pregnancy Trade Composition Dose Pack size Company name Inj: Human Chorionic Cow, heifer: 5 ml Intervet Chorulon Gonadotrophin Improvement of conception rate: (hcg) as a white 1500 IU, IM/IV at AI or mating freeze dried and / or 4 to 6 days later (1 vial with crystalline Treatment of follicular cysts: solvent for powder: 1500 IU/ 3000 IU IV. reconstitution.) ml Mare: Induction of ovulation (follicles > 3,5 cm diameter): 1500 - 3000 IU IM/IV 24 hours before AI or mating Oxytocin Mode of action: Increase uterine tone help in parturition, stimulate myo-epithelial cell of mammary gland and help in milk lay down. Indication: Induction of parturition, open cervix pyometra, myometrial contraction, postpartum haemorrhage, uterine involution, incomplete dilation of cervix, uterine inertia, retained placenta, agalactia, mastitis, abortion. Generic: Dog: 5–20 IU/dog IM. Cat: 3–5 IU/cat, IM. Horse: 10–20 IU/450 kg, IM/IV. Cattle: 20–60 IU, IM. Swine: 20–50 IU, IM or 5–10 IU, IV. Sheep, goat: 10–20 IU, IM. 267 Contraindication: Close cervix during parturation, displaced foetus. Trade name Composition Dose Inj. Oxcin-10 vet Synthetic Oxytocin BP- 10 IU/mL Inj. IntertocineS Do Inj. Unioxytocin Inj. Pitocin Do Do IM/SC Cow, Buffalo: 1-5 ml, Horse: 0.5-5 ml, Calves, Goat, sheep: 0.5-3 ml, Dog, cat- 0.5-1 ml Cow, Buffalo: 1-5 ml, IM/SC. Goat, sheep: 0.5-3 ml, IM/SC. Dog: 0.1 – 1 ml, IM/SC Cat: 0.1 - 0.5 ml, IM/SC Pig: 0.5 – 3 ml, IM/SC Cow, Mare: 4-6 ml, IM/SC Doe, Ewe: 1-2 ml, IM/SC IM/SC Cow, Horse, Buffalo: 4-5 ml, Goat, sheep: 1-3 ml, Dog, cat- 0.5-1 ml Milk let-down in cow: 0.5-1 ml Pack size Company 10 ml vial Techno Do Intervet Do ACI Do Chemist 268 Anesthetics ❖ Preanesthetics a. Anticholinergics Atropine and glycopyrrolate are the anticholinergics used most commonly in veterinary medicine. Both are relatively nonselective muscarinic antagonists, but despite this lack of selectively the effectiveness of muscarinic blockade varies considerably from tissue to tissue. Atropine sulphate Pharmacology/Actions: Atropine, like other antimuscarinic agents, competitively inhibits acetylcholine or other cholinergic stimulants at postganglionic parasympathetic neuroeffector sites. High doses may block nicotinic receptors at the autonomic ganglia and at the neuromuscular junction. Pharmacologic effects are dose related, ✓ At low doses salivation, bronchial secretions, and sweating (not horses) are inhibited. ✓ At moderate systemic doses, atropine dilates and inhibits accommodation of the pupil, and increases heart rate. ✓ High doses will decrease GI and urinary tract motility. Very high doses will inhibit gastric secretion. Generic dose- 0.02 to 0.04 mg/kg, IM/IV/SC but IM and IV routes are preferred for better uptake. ➢ After intramuscular (IM) administration, onset of cardiovascular effects occurs within 5 min and peak effects occur within 10 to 20 min. ➢ After intravenous (IV) administration at a dose of 0.03 mg/kg, onset of cardiovascular effects occurs within 1 min, peak effects occur within 5 min and heart rate increases by 30% to 40% for approximately 30 min. ➢ The effects of atropine on other body systems subside within a few hours, but ocular effects can persist for 1 to 2 days. Contraindication: Atropine use in pregnancy may cause fetal tachycardia. Trade name Composition Dose Pack size Company Inj. Tropin vet Each ml injectable As Pre-anaesthetia 10 ml ACME solution contains Dog & Cat: 1 ml/25 kg body vial Atropine Sulphate weight subcutaneously. BP 1 mg Sheep/Goat: 1 ml/5 kg body weight intravenously. Inj. Atrovet Do Do Do Techno ✓ Glycopyrrolate isn’t available in BD. b. Benzodiazepine These are the important sedatives and hypnotics because of their high therapeutic index, least adverse effects on the cardiopulmonary functions. These are used as hypnotics, sedatives, tranquilizers and anticonvulsants in animals. All compounds of this class hasten the onset of sleep, reduce the intermittent awakening and increase the total sleep time. Benzodiazepines produce relaxation, without affecting the voluntary activity. Depending on the duration of action, these are divided into two groups: a) Long acting Benzodiazepines: Diazepam, Flurazepam, Nitrazepam etc. b) Short acting Benzodiazepines: Midazolam, Triazolam, Lorazepam, Oxazepam etc. ✓ Diazepam, midazolam and zolazepam are the benzodiazepine agonists used most commonly in animals. 269 Diazepam Mechanism of action.: Benzodiazepines activate GABA-gated Cl− channels to potentiate the channel opening activity of GABA, thereby evoking hyperpolarization of the neurons. Uses/Indications: Diazepam is used clinically for its anxiolytic, muscle relaxant, hypnotic, appetite stimulant, and anticonvulsant activities. It is also used in preanesthesia protocols for neuroleptanalgesia. Generic dose: ✓ Ruminants- 0.5 to 1.1 mg/kg, IV. Diazepam at 0.2 mg/kg, IV has been used to produce mild tranquilization. ✓ Dogs- 0.3–0.5 mg/kg, IV for Status epilepticus. Or 0.1–0.5 mg/kg, IV for Preanesthetic. ✓ Cat- 0.05–0.15 mg/kg, IV for Appetite stimulant. ✓ Horse- 0.03–0.5 mg/kg; IV before induction of anesthesia with ketamine. (The drug should not be administered IM because it is very irritating and is poorly absorbed. The parenteral formulation of diazepam is administered by slow IV injection to avoid pain, thrombophlebitis, and cardiotoxicity.) Pregnancy Safety: not safe. Trade name Composition Dose Pack size Company Inj. Sedil Diazepam1 ml/10 kg, IV 2 ml ampoule Square 5 mg/ml (as 0.5 mg/kg) Inj. Easium Opsonin Do Do Do Inj: G Diazepam Gonoshasthaya Do Do Do Tab. Sedil-5 mg Diazepam1 tab/10 kg, PO 5 mg tablet Square 5 mg (as 0.5 mg/kg) Tab: Easium-5 mg Opsonin Do Do Do Tab. G Diazepam Gonoshasthaya Do Do Do Midazolam Pharmacology/Actions: Midazolam exhibits similar pharmacologic actions as other benzodiazepines. The subcortical levels (primarily limbic, thalamic, and hypothalamic), of the CNS are depressed by the benzodiazepines thus producing the anxiolytic, sedative, skeletal muscle relaxant, and anticonvulsant effects seen. Uses/Indications: In veterinary patients, midazolam is used principally as a premedicant for general anesthesia. Alone, it does not appear to provide predictable sedation in animals. Animals may become sedated or dysphoric and excited. Cats may be more prone to develop the “excited” effect more than dogs. When used in combination with other drugs (i.e., opioids or ketamine), midazolam does provide more predictable sedation. Midazolam may also be of benefit to treat status epilepticus when given either IV or IM (not rectally). Generic Dose: Dogs and cats- As a preoperative agent: 0.2–0.4 mg/kg IV/IM. For status epilepticus: 0.1–0.25 mg/kg IV/IM. Pregnancy Safety: not safe. Trade name Composition Dose Pack size Company Inj. Midolam Midazolam- 5 mg/ml 1 ml/25 kg, IV/IM 3 ml ampule Opsonin (as 0.2 mg/kg) C. Alpha 2 adrenergic Alpha 2-agonists are the most widely used class of sedatives in veterinary medicine for their reliable dose dependent sedation, analgesia and muscle relaxation that can be readily reversed by administration of selective antagonists. 270 Mode of Action: The α2 agonists (Xylazine, Detomidine, Meditomidine, Romifidine) produce their pharmacologic effects by their actions on both the central and peripheral α2 adrenoceptors. Stimulation of central (presynaptic) α2 adrenoceptors inhibits the release of catecholamines, thus reducing the response to excitatory input and as a result sedation occurs. Xylazine Function at therapeutic dose✓ Emesis in dog and cats ✓ Reliable sedation ✓ Good muscle relaxation ✓ Reduce intraocular pressure ✓ Causes excessive salivation ✓ Relief visceral pain ✓ Increase urine output ✓ Bradycardia ✓ Decreased cardiac output ✓ Reduces gastrointestinal and ruminal motility ✓ Increase myometrial and intrauterine pressure in ruminants ✓ Can be used as epidural anesthetic. Generic Dose: ✓ Ruminats-0.1-0.2 mg/kg, IM/IV. ✓ Dogs and cats- 1-2 mg/ kg, IM/IV. ✓ Horse- 1 mg/kg IV; 2 mg/kg IM ✓ Pig: 0.5-3 mg/kg, IM. (The drug is also used in combination with ketamine to provide anesthesia for brief surgical procedures. Pregnancy Safety: Limited information was located on the safety of xylazine in pregnancy; apparently, there are no reports of teratogenicity in animals. Xylazine may induce premature parturition in cattle. Xylazine does not appear to be excreted in detectable quantities in cows’ milk. Trade name Composition Dose Pack size Company Inj. Xylazine Xylazine Ruminats-1 ml/ 200-100 kg, 30 mL Indian (20 mg/ml) IM/IV. vials immunologicals Dogs and cats- 1 ml/20-10 kg, Ltd. IM/IV. Horse- 1 ml/20-10 kg, IM/IV. ➢ The pharmacologic effects induced by any one of the α2 agonists can be antagonized effectively with alpha 2 antagonist, such as yohimbine, tolazoline, or atipamezole. Yohimbine is used as a selective α2-receptor antagonist of the sedative and cardiovascular effects of xylazine at ratios of approximately 10:1, 2:1, and 10:1, for dogs, cats, and deer, respectively. Therefore, if the initial dose of xylazine is 0.5 mg/kg for a dog, then yohimbine would be given IV at a dose of 0.05 mg/kg. ✓ Detomidine, Meditomidine, Romifidine aren’t available in BD. D. Opioid analgesics Examples of drugs in this class are Morphine Sulphate, Buprenorphine, Fentanyl, Nalbuphine Hydrochloride, Oxymorphone Hydrochloride, Pentazocine Hydrochloride, and Tramadol Hydrochloride. The drugs bind to opioid receptors in the CNS which usually have inhibitory effects on neurons. Mechanism of action: ➢ When opioid agents are bound to their specific receptors, the membrane G-proteins are activated. 271 ➢ Activated G-proteins open potassium channels in the neuronal membrane, hyperpolarizing the neuron. ➢ The neuron becomes unresponsive to excitatory input, and blocks the neurotransmission. ➢ Primary clinical effects are analgesia and sedation. Main clinical uses: are to provide analgesia, decrease anxiety, provide sedation/chemical restraint (variable, depends on species, agent and dose), and decrease doses of other agents for synergism . Duration of action: depends on the type of agents used as well as dose and route of administration, widely ranging from 30 minutes (fentanyl) to several hours (buprenorphine). Combination of opioid with tranquilizer is the most popular practice for sedating or chemically restraining animals (neuroleptanalgesia). These combinations provide heavy sedation and analgesia for minor surgical procedures or allow endotracheal intubation (airway support or anesthetic induction). Pregnancy Safety: not safe. Some examples of commonly used combinations are: ✓ Morphine + acepromazine ✓ Morphine + diazepam ✓ Morphine + medetomidine ✓ Butorphanol + medetomidine ✓ Butorphanol + diazepam ✓ Hydromorphone + acepromazine ✓ Hydromorphone + diazepam ✓ Hydromorphone + medetomidine ✓ Oxymorphone + acepromazine oxymorphone + diazepam ✓ Oxymorphone + medetomidine. ✓ Fentanyl+droperidol, etc... 1. Morphine Sulphate: Morphine is used for the treatment of acute pain in dogs, cats, horses, swine, sheep, and goats. It may be used as a preanesthetic agent in dogs and swine. Additionally, it has been used as an antitussive, antidiarrheal, and as adjunctive therapy for some cardiac abnormalities (see doses) in dogs. Due to its poor oral bioavailability in dogs, oral morphine is not recommended in canines. Generic Dose: Trade name Composition Dose Pack size Company 272 Inj. G Morphine Morphine sulphate- 15 mg/ml Tab: G Morphine SR Morphine sulphate-15 mg Calculate dose as per generic requirement Do 5 ml ampoule Gonoshasthaya 15 mg tab Do 2. Buprenorphine: Buprenorphine is most often used as an analgesic for mild to moderate pain in small animals. Partial mu-opiate agonist used primarily as an injectable & buccal analgesic in small animals, especially cats; has been used in horses also. Generic Dose: Trade name Tab: Bugesic Composition Buprenorphine-200 mcg Dose Calculate dose as per generic requirement Pack size 200 mcg tablet Company Beximco 3. Fentanyl: used parenterally & transdermally in small animals ( dog,cat) for postoperative pain. Generic Dose: Trade name Inj. Fentyl Composition Fentanyl- 25 mcg/ml Dose Pack size Company Calculate dose as per 2 ml Popular generic requirement 4. Tramadol Hydrochloride: Tramadol may be a useful alternative or adjunct for the treatment of post-operative or chronic pain or cough in dogs and potentially, other species. Generic Dose: Trade name Inj: Anadol Composition Tramadol Hydrochloride- 50 mg/ml ❖ Dose Calculate dose as per generic requirement Pack size 2 ml amp Company square General anesthetics- (Injectable anesthetics, Inhalation anesthetics) 1. Injectable anesthetics A. Barbiturates Barbiturates are classified according to the duration of action: Long acting: phenobarbital Short acting: pentobarbital Ultra-short acting: thiopental, thiamylal, methohexital. Pharmacologic effects barbiturates: 273 (1) Cardiovascular effects: IV injection in the normovolemic patient causes transient hypotension and an increase in heart rate. (2) Ventilatory effects: Transient apnea following the IV injection of these compounds occurs fairly commonly as a result of depression of the respiratory centers in the brain stem. (3) CNS effects: (a) Barbiturates cause a dose-dependent depression of the CNS function. i. Low doses may cause sedation or excitement. ii. Moderate doses cause general anesthesia. iii. High doses lead to profound CNS depression. iv. Overdoses cause apnea and, eventually, cardiovascular depression and death. (b) Barbiturates decrease cerebral blood flow, cerebral oxygen consumption, cerebral blood volume, and intracranial pressure. (4) Effects during pregnancy and delivery: Placental transfer of barbiturates is rapid after IV injection. (5) Analgesic effects: Barbiturates are not analgesic in subanesthetic doses. There is evidence that some barbiturates are hyperalgesic at subanesthetic doses. Phenobarbital Long-acting barbiturates is the least lipid soluble and the slowest in their onset of action, but they have a long duration of action (6–12 hours). Phenobarbital is used primarily as an anticonvulsant/ antiseizure at subanesthetic doses, not as a general anesthetic. Generic Dose: Dog, cat: Loading dose of 16–20 mg/kg once IV; maintenance dose 1–5 mg/kg PO q12h. Pregnancy Safety: not safe. Trade name Composition Dose Pack size Company Inj: Barbit Phenobarbitone sodiumCalculate dose as per 1 ml Incepta 200 mg/ml generic requirement Inj. Emer Incepta Do Do Do Tab: Barbit 30 Phenobarbitone sodiumDo 30 mg, Do 30 mg Tab: Barbit 60 Phenobarbitone sodiumDo 60 mg Do 60 mg Soln: Barbit Phenobarbitone sodiumDo 50 ml, Do 20 mg/5 ml 100 ml Thiopental Sodium Thiopental is administered by IV injection for short duration anesthesia in dogs and cats. In large domestic animals (e.g., horses, cattle), the thiobarbiturates are commonly administered with guaifenesin, a central acting muscle relaxant. Therapeutic uses i. Thiobarbiturates are considered one of the drugs of choice for induction of anesthesia in animals with suspected increased intracranial pressure. ii. The plasma t1/2 is 3–4 hours. iii. These agents can be used for maintenance of anesthesia; however, repeat doses may lead to slow recovery because of saturation of the redistribution sites. iv. Thiobarbiturates are safe for induction of anesthesia for cesarean section because these drugs redistribute rapidly in the dam and fetus. By the time the fetus is delivered, the fetal blood levels are quite low. Pharmacology/Actions: Because of their high lipid solubility, thiobarbiturates rapidly enter the CNS and produce profound hypnosis and anesthesia. They are also known as ultrashort-acting barbiturates. Their duration of action is short (10–30 minutes). Pregnancy Safety: not safe. Generic Dose: 274 Dog, Cat: 8-22 mg/kg IV. Horse: 4-15 mg/kg, IV. Cow: 4-22 mg/kg, IV. Sheep: 8-15 mg/kg, IV. Goat: 8-20 mg/kg, IV. Trade name Composition Inj. Genisia Thiopental Sodium 500 mg/ vial Inj. G-Thiopentone IV Inj. Thiopen 500 Inj. Thiopen 1 g Inj. G-Thiopentone IV Do Do Thiopental Sodium 1 gm/ vial Do Dose Calculate dose as per generic requirement Do Do Do Do Pack size 500 mg vial+ 10 ml WFI Do Do 1 gm vial+ 10 ml WFI Do Company Square Gonoshasthaya ACI ACI Gonoshasthaya B. Non-barbiturates Propofol (Phenol derivative) Short-acting injectable hypnotic agent. In appropriate patients, propofol may be useful as an induction agent (especially before endotracheal intubation or an inhalant anesthetic), and as an anesthetic for outpatient diagnostic or minor procedures (e.g., laceration repair, radiologic procedures, minor dentistry, minor biopsies, endoscopy, etc.). Propofol is used as a treatment for refractory status epilepticus, as it tends to cause less cardiovascular depression and recoveries can be smoother than with pentobarbital. Propofol may be of particular usefulness for use in Greyhounds and in patients with preexisting cardiac dysrhythmias. At low dosages, propofol is being investigated as an appetite stimulant in dogs. In dogs, propofol’s labeled indications are: 1) for induction of anesthesia; 2) for maintenance of anesthesia for up to 20 minutes; 3) for induction of general anesthesia where maintenance is provided by inhalant anesthetics. Generic Dose: Without premedication: 6-8 mg/kg, IV With premedication: 2-4 mg/kg, IV After IV administration, propofol rapidly crosses the blood brain barrier and has an onset of action usually within one minute. Pregnancy Safety: safe. Trade name Composition Dose Pack size Company Inj. Pofol IV Propofol- 10 mg/ml Calculate dose as per 20 ml vial Popular generic requirement Inj. Propofol Do Do Do Techno Inj. Fresofol Do Do Do Fresenius Kabi Austria GmbH, Austria. C. Dissociative anesthetic ketamine, and tiletamine are dissociative anesthetics currently available in veterinary practice. Ketamine 275 Ketamine is a rapid acting general anesthetic that has significant analgesic activity (Profound analgesia without muscle relaxation) and a relative lack of cardiopulmonary depressant effects in healthy animals. It is thought to induce both anesthesia and amnesia by functionally disrupting the CNS through over stimulating the CNS or inducing a cataleptic state. Ketamine inhibits GABA, and may block serotonin, norepinephrine, and dopamine in the CNS. The thalamoneocortical system is depressed while the limbic system is activated. It induces anesthetic stages I and II, but not stage III. In cats, it causes a slight hypothermic effect as body temperatures decrease on average by 1.6°C after therapeutic doses. Caution: Significant hypertension, heart failure, & arterial aneurysms, hepatic or renal insufficiency, seizure disorders, Cats’ eyes remain open after ketamine; protect. Adverse Effects: Hypertension, hypersalivation, respiratory depression, hyperthermia, emesis, vocalization, erratic & prolonged recovery, dyspnea, spastic jerking movements, seizures, muscular tremors, hypertonicity, opisthotonos, & cardiac arrest; pain after IM injection may occur. Overdosage/Acute Toxicity: Ketamine is considered to have a wide therapeutic index (approximately 5 times greater when compared to pentobarbital). Generic Dose: Dog, Cat: 4-10 mg/kg, IV/IM. Ruminants: 2-4 mg/kg, IV/IM. Rabbit: 20-50 mg/kg, IM. Horses: 2 mg/kg, IV. (Note: Ketamine is often combined in use with other anesthetics and sedatives such as benzodiazepines (diazepam), propofol, opiates (hydromorphone) or alpha 2 agonists (medetomidine, dexmedetomidine, and xylazine). Such combinations have been synergistic and allowed lower doses of each individual component.) Trade name Composition Dose Pack size Company Inj. Ketalar Ketamine- 50 Calculate dose as per 10 ml vial Popular mg/ml generic requirement Inj. G-ketamine Do Do Do Gonoshasthya Inj. Kain Do Do Do Renata Inj. Ketaride Do Do Do Incepta ✓ Tiletamine: is not available in BD. 2. Inhalation anesthetics ✓ Isoflurane, Halothane, Sevoflurane, Enflurane, Desflurane are currently in use. Isoflurane Inhalant general anesthetic. It is associated with rapid induction of anesthesia and rapid recovery rates. Some key pharmacologic effects noted with isoflurane include: ✓ CNS depression, ✓ depression of body temperature regulating centers, ✓ increased cerebral blood flow, ✓ respiratory depression, ✓ hypotension, ✓ vasodilatation, ✓ myocardial depression ✓ muscular relaxation. Contraindications: History or predilection towards malignant hyperthermia Adverse Effects: Dose related hypotension, respiratory depression, & GI effects (nausea, vomiting, ileus); cardiodepression generally is minimal at doses causing surgical planes of anesthesia. Arrhythmias are rare. Pregnancy Safety: May be fetotoxic. Use during pregnancy with caution. 276 Generic Dose: Dog, Cat: 5% (induction); 1.5–2.5% (maintenance). Trade name Composition Dose Flurane Isoflurane Calculate dose as per (solution for inhalation) 100% generic requirement Pack size 100 ml Company Techno Halothane Classic inhalant general anesthetic. It is associated with rapid induction of anesthesia and rapid recovery rates. However, it is rarely used today and has been replaced by newer inhalant anesthetics (eg, isoflurane) in many veterinary practices. Some key pharmacologic effects noted with halothane include: ✓ CNS depression, ✓ depression of body temperature regulating centers, ✓ increased cerebral blood flow, ✓ respiratory depression (pronounced in ruminants), ✓ hypotension, ✓ vasodilatation, ✓ myocardial depression. Contraindications: History or predilection towards malignant hyperthermia; significant hepatotoxicity after previous exposure. Adverse Effects: Dose related hypotension, malignant hyperthermia-stress syndrome, cardiac depression & dysrhythmias, hepatotoxicity. Pregnancy Safety: May be teratogenic; use with caution in pregnancy. Generic Dose: Dog, Cat: 3% (induction); 0.5–1.5% (maintenance). Trade name Composition Dose Pack size Company Halosin Halothane- 1.87 Calculate dose as per 200 ml, ACI (solution for inhalation) gm/ml generic requirement 250 ml ✓ Sevoflurane: Inhalational anesthetic similar to isoflurane, but with more rapid induction & Recovery. Currently much more expensive than isoflurane. ✓ Enflurane, Desflurane are not available in BD. ❖Local anesthetics Mode of Action: Local anesthetics are a group of chemically related compounds that reversibly bind sodium channels and block impulse conduction in nerve fibers. The interruption of neural transmission in sensory afferent nerves or tracts by a local anesthetic drug after local tissue infiltration, regional nerve blocks, or epidural or intrathecal (subarachnoid) injection uniquely and most effectively prevents or reduces pain or nociceptive input during and after surgery. Classification: Esters- Cocaine, Benzocaine, Procaine, Chloroprocaine, Tetracaine. Amides- Lidocaine, Mepivacaine, Prilocaine, Bupivacaine. Benzocaine Trade name Oral Gel: Oratics Composition Each gram gel contains 0.2 gm of Benzocaine. Dose Pack size Company Apply topically 5 gm tube Acme as per requirement Oratics Indication : It is indicated for the temporary relief of pain due to minor injury or irritation of the mouth and gums like- toothache, canker sores, sore gums, minor dental procedures, and dentures. It is also indicated as a topical anesthetic for use on oral mucosa prior to local anesthetic injections, scaling and prophylaxis. Lidocaine Therapeutic uses 277 1. Anesthesia a. Topical anesthesia. b. Infiltrative anesthesia. c. Peripheral nerve blocks are used to desensitize larger areas. For example, a paravertebral nerve block would be used to desensitize the paralumbar fossa of a cow prior to a laparotomy. d. Epidural injection of a local anesthetic desensitizes the spinal cord or cauda equine and is useful for procedures such as caudal abdominal, pelvic limb, or perineal surgery. 2. Control of arrhythmias: Lidocaine infused or injected IV is used to control premature ventricular contractions. 3. Constant rate IV infusion of lidocaine produces analgesia which facilitates general anesthesia and may be part of a multimodal approach to pain control postoperatively. 4. IV infusion of lidocaine in the horse may increase intestinal motility and be useful in treating some forms of hypomotility. The mechanism of action is unknown but thought to involve antiinflammatory, analgesia, or altering the sympathetic inhibitory reflexes by suppressing the nerve transmission in afferent sensory pathways. Three time more potent than procaine Generic Dose: 4-7 mg/kg. or 1 ml/ cm area. Toxic dose- 8 mg/kg, much lower in cat- 2 mg/kg. Route- Topical/Surface, Infiltration, Regional IV. Onset of action- 5 to 10 mins. Duration- Duration of action is variable (depending on uptake) but wil l be around 1 hour without epinephrine, and 2 hours with epinephrine. Pregnancy Safety: safe. Trade name Inj. Jasocaine 1% Composition Lidocaine Hydrochloride10 mg/ml Inj. Jasocaine 2% Lidocaine Hydrochloride20 mg/ml Inj. G-Lidocaine (2%) Inj. Jasocaine 4% Gel: Jsocaine 2% Spray: Jasocaine Spray: Lido Spray: Xyloken Dose Calculate dose as per generic requirement Do Pack size 50 ml vial Company Jayson 50 ml vial Jayson Do Do Gonoshasthaya Lidocaine Hydrochloride40 mg/ml Lidocaine Hydrochloride2% Do 2 ml ampoule 50 ml vial 2 ml amp Apply topically as per requirement Do 15 gm, 30 gm tube 30 ml Jayson Do Do 30 ml 10 ml, 50 ml Square Opsonin Lidocaine Hydrochloride10 mg/spary Do Do Jayson Jayson Bupivacaine Pharmacology and Mechanism of Action: Bupivacaine inhibits nerve conduction via sodium channel blockade. Bupivacaine has a slow onset of action (20 minutes), but is longer acting (6-8 hours) and 278 more potent than lidocaine or other local anesthetics. Epidural onset of action is approximately 1520 minutes with a duration of 2-4 hours. Indications and Clinical Uses: Bupivacaine is used for local anesthesia and epidural analgesia/anesthesia. It is administered by local infiltration or by epidural injection. Generic Dose: Dogs and Cats: Epidural dose- 1-1.5 mg/kg for nerve blocks, usually 0.2 ml/kg of 0.5% solution is used. Large Animal Dosage: Limited to local infiltration for minor surgery. Trade name Composition Dose Pack size Company Inj. Ultracaine -0.25% Bupivacaine: 2.5 mg/5 ml Calculate dose 20 ml Jayson as per generic requirement Inj. Ultracaine -0.5% Bupivacaine: 5 mg/ml Do 30 ml Jayson Inj. Ultracaine Heavy Bupivacaine + Dextrose: Do 4 ml amp Jayson (Intraspinal injection) 0.5% + 8% ({20 mg + 320 mg}/ 4 ml) Prilocaine Trade name Cream: Topican Composition Dose Pack size Company Lidocaine + Prilocaine topical: Apply topically 5gm tube Popular (2.5 gm + 2.5 gm)/ 100 gm. as per requirement Indication of Topican: Topical anesthetic for local analgesia on normal intact skin, vaginal mucous membranes for superficial minor surgery, and as a preparation for infiltration anesthesia. ✓ Cocaine, Procaine, Chloroprocaine, Tetracaine, Mepivacaine, aren’t available in BD. ➢ (Anesthetics are Human trade, not veterinary. Follow DIMS app for more trade.) 279 Vaccines Vaccine: Vaccine is a biological preparation of attenuated or killed micro-organisms or parts or products of it, used as antigen to confer immunity. Classification of vaccines: A) Classical: 1) Live attenuated 2) Inactivated: a) Organism b) Toxin c) Subunit B) Synthetic: 1) Recombinant vaccine 2) DNA vaccine Vaccination: Vaccination is the administration of an antigen (vaccine) to stimulate a protective immune response against an infectious agent. Types of vaccination: 1) Individual vaccination 2) Mass vaccination Vaccines/vaccine providers to do: The purpose of vaccination or vaccination is to protect animals from disease, but many times the incidence of disease cannot be reduced with vaccines, even before the development of immunity, many animals have accidents. Adverse reactions such as severe pain, salivation, restlessness and even death in animals have occurred immediately after vaccination. Sometimes, as a side effect of the vaccine, the muscles at the injection site become very swollen or boil. Even the milk dries up. In order to avoid these accidents, the vaccine provider must adhere to the following points. (1) Validity of the vaccine should be checked i.e. the expiry date of the vaccine should be confirmed. (2) Vaccine should be kept in cool box or flux until use. (3) Shake the bottle well before use so that the vaccine is evenly mixed. (4) The vaccine is usually best given in the morning. (5) The vaccine bottle should be kept away from direct sunlight. (6) All cows-buffaloes, goats-sheep should be vaccinated together. (7) It is best to complete administration of the vaccine within 2 hours of opening the bottle. (8) The vaccine should be used in a shade or under a tree. (9) Any vaccine should be administered to one animal first and observed for 15-20 minutes for any side effects, if not then safely administered to the rest of the animals. (10) Vaccines to be given under the skin should not be injected into the muscles under any circumstances. (11) Vaccination should be given only to healthy animals. (12) Vaccination should not be given to weak animals and animals below 4 months of age. Reasons why vaccines are ineffective: Reasons why cattle are not protected against disease after vaccination are given below. 1. If the disease that the animal is vaccinated against is already dormant in the animal's body, the vaccine will not be effective, but the disease will appear more quickly. For this reason, after showing symptoms of disease in any animal farm/flock, the farm/flock should not be vaccinated against the disease at any time. 280 2. If the quality of the vaccine is not correct i.e. if it is of low quality, even applying the vaccine will not work. Usually the pathogen strain, type and the vaccine strain, type need to be the same. Otherwise, animals may still be infected with the disease even after vaccination. 3. If the vaccine does not enter the body properly or in sufficient quantity, the vaccine is not effective. 4. If the vaccine is not stored in a proper environment i.e. at the right temperature, the disease can occur even after the vaccine is administered. 5. Vaccines made with live bacteria can become ineffective if the bacteria are dead. 6. If the vaccine administration equipment is not clean and sterile, the effectiveness of the vaccine may be compromised. 7. The use of chlorinated water during the administration of the vaccine through drinking water destroys the effectiveness of the vaccine. 8. The vaccine must be used immediately after mixing with water and cannot be stored. 9. 15 to 25℃ after taking the vaccine out of the refrigerator during the use of the vaccine. Apply after bringing to temperature. Shake well before use. After opening the bottle, the vaccine should be used within 4 hours in summer and 8 hours in winter. Otherwise the efficacy of the vaccine may be impaired. 10. Vaccines that have expired will not be effective. 11. Vaccination to sick and weak animals does not build immunity. Farm animal vaccines Vaccines of Livestock Research Institute (LRI), Mohakhali Vaccine against Foot & Mouth Disease (FMD) Vaccine name Composition Age, Dose ক্ষুরা ভরাটগর ষ্টেকা Master seed: A, O & Asia-1 serotype Age 1. This vaccine should be administered to animals of 1 (one) month of age if the mother has not been vaccinated and of 4 (four) months of age if the mother has been vaccinated. However, a booster dose administered 21 days after the first dose of birth increases immunity. 2. Regularly vaccinated animals should be vaccinated every 6 (six) months and irregularly vaccinated animals every 4 (four) months. Dose Cattle, Buffalo: 6 ml, Under the skin of the neck S/Cly. Calves: 3 ml, Under the skin of the neck S/Cly. Sheep, goat: 2 ml, Under the skin of the neck (S/Cly). Foot & Mouth Disease Vaccine (Trivalent) (killed vaccine) Preservation, Caution 1) Can be stored at 4° to 8° C temperature up to 3-6 months. 2) Pregnant cows can be vaccinated. Pack size (Supply) Trivalent vaccine: 16 doses of vaccine for cattle/ buffalo and 48 doses of vaccine for goats/ sheep per vial. Price: Tk 160.00 only. Vaccine against Anthrax 281 Vaccine name Composition Age, Dose ত্ডকা ষ্টেকা Master seed: 34 F2 strain Origin: Australia Age 1. This vaccination is administered to cattle and buffaloes of six months of age or above. 2. Boostering: In all the areas where there is a history of Anthrax disease i.e. Enzootic areas, this vaccination should be applied regularly once a year. Dose Cattle, Horse, Buffalo: 1 ml, Under the skin of the neck (S/Cly). Sheep, goat: 0.5 ml, Under the skin of the neck (S/Cly). Anthrax Vaccine (Live vaccine) Preservation, Pack size Caution (Supply) 1) Can be 100 doses stored at 4° to of vaccine 8° C for cattle, temperature up buffaloes, to 6 months. horses and 2) Vaccination 200 doses in pregnant of vaccine cows above six for months is likely goats/sheep to cause per vial. abortion, so it is better not to Price: Only give vaccination Tk 50.00 at that time. per vial. 3. In case of goats/sheep it should not be given after 3 months of pregnancy. Vaccine against Black Quarter Vaccine name Composition বািলা ষ্টেকা Master seed: Local strain Black Quarter Vaccine (killed vaccine) Age, Dose Preservation, Pack size Caution (Supply) Age 1) Can be stored 20 doses of 1. Animals aged 6 months to 3 at 4° to 8° C vaccine for years are vaccinated against temperature up cattle/ distemper. to 6 months. buffalo and 2. Full immunity develops 50 doses of within 2 to 3 weeks of 2) Vaccination vaccine vaccination. Immunity lasts up of this disease is for goats/ to 6 months, so vaccination no longer sheep per should be given every 6 required after vial. months (boostering). A 2nd 2.5-3 years of dose given 4 weeks after the cow/buffalo. Price: Only st 1 dose provides long-term Tk 30.00 immunity. In that case, per vial. vaccination should be done every 1 year. Dose Cattle, Buffalo: 5 ml, Under the loose skin of the throat or neck S/Cly. Sheep, goat: 2 ml, Under the loose skin of the throat or neck S/Cly. Vaccine against Haemorrhagic Septicaemia Vaccine name Composition Age, Dose Preservation Pack size (Supply) 282 গলাফুলা ষ্টেকা Haemorrahagic Septicemia vaccine Master seed: Local strain Age: ≥2 years, 2-3 weeks after vaccination, immunity begins to develop. Immunity lasts up to 6 (six) months after vaccination. So vaccination should be given every 6 months (boostering). Dose Oil adjuvant vaccine Adults (above 2 years) should be administered in 2 ml dose to cattle, buffaloes and 1 ml dose to goats, sheep. Under the skin of the neck S/Cly. (killed vaccine) 1) Can be stored at 4° to 8° C temperature up to 6 months. Calves 6 months of age and older in enzootic (history of disease) areas should be vaccinated at half the dose of adult cows. Under the skin of the neck (S/Cly). Alum precipitated vaccine Cattle, Buffalo: 5 ml, I/M Sheep/goat: 2 ml, I/M Oil Adjuvanted Vaccine: 80 doses of vaccine for Cow/Buffalo and 100 doses of vaccine for Goat/Sheep/Calf per vial. Alum precipitated vaccine 20 doses of vaccine for Cow/Buffalo and 50 doses of vaccine for Goat/Sheep/Calf per vial. Price: Per Vial a) Oil Adjuvant Vaccine: Tk 30.00 only b) Alum precipitated vaccine: Tk 30.00 only. Vaccine against PPR Vaccine name Composition ছাগটলর হ হ আর ষ্টেকা Master seed: Local (Shahid Tito) strain Age, Dose Caution Age: This vaccine is Goats/sheep of 4 months safe to of age are vaccinated, but administer up goats/sheep of 2 months to 4 and a half PPR Vaccine Origin: BLRI, of age can also be months of Savar, Dhaka vaccinated. In that case pregnancy. (PPR=Peste des booster vaccination should This vaccine Petits Ruminants) be applied at the age of 6 should not be months. administered Boosting: Yearly. to infected (Live vaccine) Dose: goats/sheep or 1 mL per goat/sheep after affected areas. reconstitution with 100 mL diluent per vial of vaccine, administered subcutaneously Preservation Preservation temperature Expiry date after preservation -20°C 1 year Pack size (Supply) 100 doses of vaccine and 100 mL diluent per vial. Price: TK.50.00 per vial. 283 -5 to 0°C 2-8°C 6 months 1 months Vaccine against Goat Pox Vaccine name Composition ছাগটলর বসটন্তর ষ্টেকা Goat pox vaccine Master seed: Local strain (Live Spore vaccine) Dose Pack size (Supply) 100 doses of vaccine and 100 mL diluent per vial. Dose: 1 mL per goat/sheep after reconstitution with 100 mL Origin: BLRI, diluent per vial of vaccine, Price: TK.55.00 per vial Savar, Dhaka administered subcutaneously. Preservation Preservation temperature Expiry date after preservation -20°C 1 year 2-8°C 1 month Vaccine against Rabies Vaccine name: জলাত্ঙ্ক ভরাটগর ষ্টেকা (Rabies Vaccine) Composition: Master seed: Flurry strain Origin: WHO Types of vaccines and rules of use: Two types namely 1) HEP (High Embryo Passage) and 2) LEP (LEP: Low Embryo Passage) vaccines. HEP vaccine is used in cattle, cats, monkeys, guinea pigs etc. The LEP vaccine is only used in dogs. Generally: Dogs over three months of age are given this vaccine. If the mother is vaccinated, the baby has maternal antibodies for up to 6 months which act as immunity. If the mother is not vaccinated, HEP should be given at 2 months of age and LEP at 4 months of age. This vaccine should be administered regularly in healthy conditions. Name, dose and method of administration of vaccine by species and age: Animal Vaccine Age Amount Place of Resistance name application period and subsequent Dosage LEP Dog Above 3 months 3 ml IM Every 1 year HEP Puppy Below 3 months 1.5 ml IM Vaccination should be given after 12 months (LEP). HEP Cat/ Above 2 months 1.5 ml IM Every 1 year mongoose/ Monkey HEP Sheep/Goat Above 2 months 1.5 ml IM Booster dose after 1 month, Every 1 year. HEP Cattle Adult 3 ml IM Do HEP Calf After 3 months 1.5 ml IM Do Caution: Vaccination must be administered in the flesh. Under no circumstances should it be applied under the skin. Preservation: Preservation temperature Expiry date after preservation 284 -20°C 1 year 0°C 48 hours Pack size (Supply): 1 dose vaccine and 5 mL diluent per vial Price: Tk 25.00 per vial. Reference: http://lri.gov.bd/site/page/de62cf55-2f6f-495f-b8ea-7072e965280d/- Commercial preparations Vaccines of Indian Immunologicals Limited Vaccine name: RAKSHA-OVAC TRIVALENT Raksha - Ovac (FMD Oil Adjuvant vaccine) is a unique Double Emulsion Oil Adjuvant Vaccine and is recommended for prophylactic vaccination against Foot and Mouth Disease in cattle, buffaloes, sheep, goats and pigs. Composition: Raksha - Ovac Trivalent (FMD Oil Adjuvant vaccine) contains tissue culture virus strains, O, A, Asia-1, and inactivated with Aziridine compound. Mineral oil is added as an adjuvant. Administration: The vaccine vial should be kept cold until used and each vial should be well shaken before contents are withdrawn. Syringes and needles must be sterilized before use. The vaccine should be injected subcutaneously or intramuscularly through an area of clean, dry skin with precautions taken against contamination. Dosage: Cattle, Buffaloes, Calves and Pigs: 2 ml Sheep and Goats: 1 ml Vaccination regimen: Primary vaccination : 4 months of age (Cattle, Buffaloes, Sheep and Goats). 2 months of age (Pigs). Booster: 9 months after primary vaccination (Cattle/buffaloes/Sheep and Goats). Revaccination: Every 12 months thereafter (Cattle, Buffaloes, Sheep and Goats), Every 6 months thereafter (Pigs). Storage and transport: The vaccine should be stored and transported between 2°C and 8°C. Antigenicity of the vaccine deteriorates if the temperature is allowed to rise above this range, the rate of deterioration depending on both temperature and time. At no stage should the vaccine be frozen. Presentation: Raksha - Ovac Trivalent vaccine is available in 100 ml Packs. Manufactured and marketed by Indian Immunologicals Limited Vaccines of Incepta Vaccine name: KhuraVax Vet (ÿzivf¨v· ‡fU) Composition: Each dose of vaccine contains Trivalent Foot and Mouth Disease Inactivated antigens O, A and Asia-1 strains, adjuvanted with mineral oil. Age: Primary vaccination: 3 to 4 months of age and onwards Booster: 1-1.5 month after primary vaccination Revaccination: Every 6 months after booster and every 4 months in endemic areas like Bangladesh. Or as directed by the registered Veterinarian. Dosages: Regardless of the age and weight of the animal, refer to the label on the container according to the following schedule. Cattle, Buffaloes & Calves: 2 ml Goat & sheep: 1 ml Vaccine should be injected intramuscularly in the middle or deep gluteal muscle. Preservation: The vaccine should be stored and transported between +2 ℃ and +8 ℃. Do not freeze the vaccine. 285 Use in pregnancy & lactation: There is no contraindication of the vaccine for pregnant animals Commercial Packaging: Khuravax Vet 5 Doses: Each vial contains 10 ml vaccine which is closed by chlorobutyl rubber stopper and flip off seal. Khuravax Vet 10 Doses: Each vial contains 20 ml vaccine which is closed by chlorobutyl rubber stopper and flip off seal. Vaccines of Square Pharmaceuticals Vaccine name: Rabisin Ingredients and content Rabies virus glycoprotein: > = 1 IU Thiomersal, most: 1 mg Aluminium adjuvant (hydroxide form): 1.7 mg Excipients q.s for 1 dose in 1 ml Uses: Rabies prevention for dogs, cats, horses, sheep, buffaloes, cows and weasels. Instructions and dosage: Pre exposure vaccination- 1 ml vaccine by subcutaneous injection according to the schedule as follows Dogs and Cats: First vaccination done from 12 weeks of age * - Repeat according to veterinary regulations Weasel: From 3 months old- Repeat every year Horse: Less than 6 months old: The first injection should be done from 4 months of age **, the second injection should be done 1 month later. From 6 months of age and older: one injection. Repeat every year. Buffalo, Cow, and Sheep: Less than 9 months old: The first injection is done from 4 months old ***, the second injection is done at about 9-12 months old. From 9 months of age and older: one injection. Repeat every year. * In the case of a dog or cat being vaccinated before 12 weeks of age, the first vaccination schedule must have one additional injection at 12 weeks of age or older. ** In all cases, the timing of repetition should be in accordance with the laws of each country. *** For horses, buffaloes, cows or sheep that were vaccinated before 4 months of age, the first vaccination schedule must be vaccinated with 1 additional injection at 4 months of age or older. Post exposure vaccination: IM/SC Species 1st day 7th day 21st day Sheep/Goat/Dog/Cat 1 ml 2 dose in 2 sites 1 ml one dose 1 ml one dose Calf/Horse/Camel/Donkey 1 ml 3 dose in 3 sites 1 ml 2 dose in 2 sites 1 ml 2 dose in 2 sites Cattle/Buffalo 1 ml 4 dose in 4 sites 1 ml 3 dose in 3 sites 1 ml 3 dose in 3 sites Contraindication: Do not inject under the skin for the horse. USE DURING PREGNANCY AND LACTATION: No adverse reactions have been reported in female cattle during pregnancy Storage: From 2°C - 8°C, protect from light. Commercial Packaging: 10 ml doses. Vaccines of Bengal Overseas Vaccine name: Lumpyvax Indications: For the prophylactic immunisation of cattle against lumpy skin disease. Composition: Each 1 mℓ (1 dose) of the vaccine contains 104 TCID50 of freeze-dried, live, attenuated virus (SIS Neethling-type). Dosage: Inject 1 mℓ per animal subcutaneously. Recommendations for use: 286 ✓ If possible, all animals should be vaccinated during spring. ✓ Calves from vaccinated cows should be vaccinated at 6 months of age. Calves from unvaccinated cows may be vaccinated at any age. ✓ Pregnant cows may be vaccinated with Lumpyvax®. ✓ A booster vaccination should be given annually. ✓ Immunity starts to develop about 10 days after immunisation and animals should be fully protected after 3 weeks. (The vaccine may not necessarily confer absolute immunity to all animals.) ✓ A small percentage of cattle are naturally immune to lumpy skin disease virus and do not develop antibodies following vaccination. When this occurs, there is no colostrum antibody protection and the calves of these cows may be at risk from an early age. Storage: Store between 2 °C and 8 °C. Do not freeze. Presentation: Vials containing 20 mℓ (20 doses) and 100 mℓ (100 doses). Manufacturer: MSD Animal Health Vaccine name: Nobivac Rabies (Inactivated vaccine) Indications: For the active immunization of healthy dogs, cats, cattle, sheep, goats, horses, ferrets, foxes and in principle all healthy mammals against rabies. It can be used for both prophylactic immunization & post bite therapy. Dosage and Administration: 1 ml by subcutaneous or intramuscular injection. Shake well before use. Vaccination Programme: Prophylaxis (Pre-exposure) Species Age at Primary Vaccination Revaccination Dog & Cat After 3 months of age * 3 years** Cattle, Horse, Sheep & Goat After 6 months of age * 2 years** Ferret After 3 months of age * 1 year** * Primary vaccination can be administered at an earlier age, but then a repeat vaccination must be given at the age of 3 or 6 months depending on the species. ** Annual revaccination is recommended in endemic areas. Post-Bite treatment (Post-exposure Prophylaxis) In all species, repeated single dose of vaccine should be administrated (by the above recommended route) according to the following schedule. Dose number Timing st 1 Day 0 (as soon as possible following bite/exposure) 2nd 3rd Day 3 Day 7 4th Day 14 th Day 28 5 Storage: Between 2 – 8°C. Avoid freezing. Presentation: One box contains 10 vials of 1 dose. One box contains 10 vials of 10 doses. Manufacturer: MSD Animal Health Vaccines of ACI Vaccine name: Bovivax LSD-N Vaccine Indications: Prophylactic immunization of cattle against Lumpy Skin Disease. 287 Composition: Each dose of vaccine contains: Live attenuated Lumpy Skin Disease virus. Strain Neethling-----103,5TClDSO Vaccination schedule: ✓ Primary-vaccination: Calves from vaccinated mothers: vaccination is carried out from the age of 4 to 6 months, Calves from unvaccinated mothers: vaccination is carried out from any age. ✓ Booster: one annual injection. It is preferable to vaccinate animals before the risk period: early spring. Dose: young and adult animals: 2 ml per animal. Administer the vaccine subcutaneously. Use during pregnancy or lactation: Tolerated. Pack sizes: Vial of 10 doses of freeze-dried vaccine Vial of 20 ml of MCI Sterile Diluent. Vial of 25 doses of freeze-dried vaccine Vial of 50 ml of MCI Sterile Diluent. Pet animal vaccines World Small Animal Veterinary Association (WSAVA) guideline Canine vaccination schedule Vaccine 1st dose DHPPi2 L 6-8 wk 2-4 wk interval until 16 wk Rabies 12 wk 1-3 yearly (high risk areas: 2nd dose 2-4wks after 1st dose) Subsequent dosages 6 m/1y later 3 yearly (DHPPi2L: D=Canine distemper, H= Infectious canine hepatitis, P= Parvo virus, Pi2=Parainfluenza type 2, L= Leptospira) Feline vaccination schedule Vaccine 1st dose Calicivirus Panleukopenia Rhinotracheitis Chlamydia 6-8 wk Rabies 12 wk Subsequent dosages 2-4 wk interval until 16 wk 6 m/1y later 3 yearly 1 yearly (RCPC= Rhinotracheitis, Calicivirus infection, Panleukopenia, Chlamydiasis) 288 Commercial preparations Vaccines manufactured by Intas Pharmaceuticals LTD. Vaccine name: CaniShot K5 CaniShot K5 is a live attenuated freeze-dried vaccine for the immunization of dogs. CaniShot K5 is a 5 in 1 vaccine against canine distemper virus (CDV), canine adenovirus type 1 (CAV1) and 2 (CAV2), canine parvovirus (CPV), and canine parainfluenza virus (Cpi). CaniShot K5 is a core vaccine. Ingredients & Composition: Each ml of CaniShot K5 after reconstitution contains: (Live and attenuated) Canine Distemper Virus (Rockborn strain) Canine Adeno Virus Type 2 (Manhattan strain) Canine Parvo Virus (780916-LP Cornell strain) Canine Parainfluenza (D008 Cornell strain) Dosage and administration: 1.0 ml (1 dose) subcutaneously. After reconstitution with enclosed diluents. Initial vaccination: 6-7 weeks after birth Second Vaccination: 8-9 weeks after birth Third Vaccination: 11-14 weeks after birth Booster Vaccination: Annually Pharmaceutical precautions / Instructions: Store in a cool and dry place or refrigerator at 2-8°C. The cold chain should be maintained. Do not freeze. Protect from light. Safety: Age / Pregnancy/ Withdrawal: Safety in lactating female or pregnant female dogs is not warned by the manufacturer. Presentation: 1 ml dose vial along with diluent Vaccines of Bioveta Vaccine name: BIOFEL PCH Composition in 1 ml: Virus panleucopeniae contagiosae felis inactivatum RP ≥ 1* Calicivirus felis inactivatum RP ≥ 1* Herpesvirus felis inactivatum RP ≥ 1* Adjuvant – oil-in-water emulsigen ad 1 ml * RP = Relative potency (ELISA test) compared with the reference serum obtained after vaccination of guinea pigs with a vaccine batch that has successfully passed the challenge test on the target species. Indication: For active immunization of cats against panleukopenia, calicivirus and feline herpesvirus. Route of administration and dosage: SC (subcutaneously) behind the shoulder blade. -1 ml irrespective of age, weight and breed of the animal since the age of 8-10 weeks. -Revaccination in 3-4 weeks after the 1st vaccination and booster vaccination every 12 months. -In cause of kitten from an immunized queen, one more revaccination about the age of 16 weeks may be needed to overcome interference of maternally derived antibodies with the vaccine. Storage: Store in a dark and dry place at 2°C-8°C. Protect from light. Do not freeze. Shelf life: 24 months. Package: 20 x 1 ml, 10 x 1 ml, 5 x 5 ml, 10 x 5 ml, 20 x 1 ml, 100 x 1 ml. Vaccine name: BIOFEL PCHR Composition in 1 ml Virus panleucopeniae contagiosae felis inactivatum RP ≥ 1* 289 Calicivirus felis inactivatum RP ≥ 1* Herpesvirus felis inactivatum RP ≥ 1* Virus rabiei inactivatum min 1 IU Adjuvant – oil-in-water Emulsigen ad 1 ml * RP = Relative potency (ELISA test) compared with the reference serum obtained after vaccination of guinea pigs with a vaccine batch that has successfully passed the challenge test on the target species. IU= International unit Indication: For active immunization of cats against panleukopenia, calicivirus, feline herpesvirus and rabies. Route of administration and dosage: SC (subcutaneously) behind the shoulder blade. -1 ml irrespective of age, weight and breed of the animal since the age of 12 weeks. -One dose of Biofel PCHR from 3 months of age, after previous administration of one dose of Biofel PCH in kittens from 8 to 10 weeks of age. -Booster vaccination every 12 months. Storage: Store in a dark and dry place at 2°C - 8°C. Protect from light. Do not freeze. Shelf life: 24 months. Package: 2 x 1 ml, 10 x 1 ml, 5 x 5 ml, 10 x 5 ml, 20 x 1 ml, 100 x 1 ml. Vaccines of Merck Animal Health Vaccine name NOBIVAC FELINE 1HCPCh Composition Dose, Age Preservation Pack size A quality core vaccine shown to be effective for vaccination of healthy cats against feline rhinotracheitis, calici, and panleukopenia viruses, as well as feline Chlamydophila Age: 9 weeks of age or older -Subcutaneous or intramuscular injection -Initial 1 mL dose administered at 9 weeks of age or older -Second 1 mL dose administered 3 to 4 weeks later -Historically, annual revaccination has been recommended for this product. Store at 2° 8°C (35°-46°F). 1 vaccine vial + 1 diluent vial (1 ml) Do not freeze. Vaccines of Square Pharmaceuticals Vaccine name: Recombitek C4 (rDAPP) Recombitek® C4 is recommended for the vaccination of healthy dogs 6 weeks of age and older for prevention of disease due to canine distemper virus, canine parvovirus, canine adenovirus type 1 (canine hepatitis), canine adenovirus type 2 (canine respiratory disease complex), and canine parainfluenza virus. Modified Live Virus. Dosage and Administration: Reconstitute the lyophilized vaccine with accompanying liquid diluent. Adminsiter 1 mL (1 dose) Recombitek C4 (rDAPP) Subcutaneous or Intramuscular into healthy dogs. For primary vaccination, revaccinate with a second 1 mL dose 2 to 3 weeks later. Dogs less than 12 weeks of age should be revaccinated with a single 1 mL dose every 2 to 3 weeks, the last dose given at or over 12 weeks of age. Revaccinate annually with a single 1 mL dose. Storage: Store in the dark at 2° to 7°C (35° to 45°F). Caution: Use immediately after reconstitution. Consult a veterinarian before administering vaccines. Vaccine name: Rabisin See farm animal vaccine, page-273 290 Poultry vaccines Vaccination schedule For Commercial Broilers Disease Type of vaccine (IB+ND)/ND Live Age Day 4-5 Day 10-12 IBD (Intermediate/ Intermediate plus strain) Live Route Eye drop Eye drop/water Day 17-18 (IB+ND)/ND Live Eye drop Day 20-22* IBD Live Eye drop/water [* If farmers rare broiler more than 28 days then last dose of IBD are taken into consider] (IB= Infectious Bronchitis, ND= Newcastle Disease, IBD= Infectious Bursal Disease) For Commercial Layers Age Disease Type of vaccine Route Day 1 Marek’s Serotype/Recombinant 0.2 ml, SC neck Day 4-5 (IB+ND)/ND Live Eye drop IBD (Intermediate Day 12-14 Live Eye drop/water /Intermediate plus strain) Day 17-18 (IB+ND)/ND Live Eye drop Day 20-22 IBD Live Eye drop/water Neck S/C or I/M in Day 28-30 ND-Killed Killed Thigh muscle Day 35 Fowl Pox Live Wing Web Method Orally by drinking Day 45 Deworming …….. water Day 55 Coryza Killed Neck S/C Neck S/C or I/M in Day 65 ND-Killed Killed Thigh muscle Day 75 Fowl Cholera Killed I/M in Thigh muscle Orally by drinking Day 90 Deworming ………. water Day 105 Coryza Killed Neck S/C Day 115 IB+ND+EDS Killed Neck S/C Day 130 Fowl Cholera Killed I/M in Thigh muscle (EDS= Egg drop syndrome) Debeaking: The best age to debeak chicks is 1 day or 7 to 14 days. Debeak a second time between 12 and 17 weeks (84-119 days) of age. Vaccines of Livestock Research Institute (LRI), Mohakhali Vaccine name Marek’s disease vaccine Composition Master seed: HVT FC-126, serotype-3 মাটরি ষ্টেকা Origin: England Dose, Age The vaccine is mixed with 200 ml diluents then administer 0.2 ml s/c-ly in day old chicks (DOC) Boostering: Not required, adapt long lasting immunity Preservation The vaccine is preserved at 25˚C for 6 months and in -20˚C (deep freeze) up to 1 year Pack size Each vial contains 1000 dose vaccine + 200 ml diluents. Price: Tk 350.00 per vial only. 291 Baby Chick Ranikhet Disease Vaccine (BCRDV) Master seed: Lantogenic F strain বাচ্চা মুরগীর রািীটক্ষত্ ষ্টেকা (হব,হস,আর,হি,হে) Origin: FAO Each vial contains 0.5 ml freeze dried vaccine. 6 ml distilled water (DW) added in the vial and agitate slowly to melt the vaccine. Then taken in eye dropper and instilled one drop in either eye. Master seed: Mesogenic muktesor M strain Vaccinate at 4-7 days old and Boostering at 21 days old. Immunity persists up to 6 to 7 weeks of age. Each vial contains 0.3 ml freeze dried vaccine. 100 ml distilled water (DW) added in the vial and agitate slowly to melt the vaccine. Then 1 ml taken in syringe and give intramuscularly in thigh muscle. Ranikhet Disease Vaccine (RDV) বড মুরগীর রািীটক্ষত্ ষ্টেকা (আর,হি,হে) Fowl pox vaccine ফাউল ি ষ্টেকা Origin: FAO Master seed: Beaudette strain Origin: Malaysia Chickens 2 months or older should be vaccinated. Immunity persists up to 6 months of age. (1) First mix well with 3 mL of distilled water in the vaccine vial. For this vaccination application, a special type of needle (Biforked Pricking Needle) or alternatively half of the injection needle is dipped into the skin of the triangular feather/featherless area of chickens aged 30 days or more. (2) This vaccine produces lifelong immunity. (3) This vaccination is sufficient once in a lifetime. It preserved in 4 to 8˚c up to 4 months, -5 to 0˚c upto 6 months and -20˚c upto one year. It can also be preserved in thermoflask with ice up to 15 days. Each vial contains 100 dose vaccine Do Each vial contains 100 dose vaccine Price: Tk 15.00 per vial only. Price: Tk 15.00 per vial only. It is preserved in -5 to 0˚c up to 5 months and 20˚c up to 1 year. Each vial contains 200 doses per vial. Price: Tk 40.00 per vial. 292 Pigeon pox vaccine হ ক্সজয়ন ি ষ্টেকা Salmonellosis/ Fowl typhoid vaccine ফাউল োইফটয়ি/ সালটমাটনটলাহসস ষ্টেকা Infectious bursal Disease vaccine Master seed: LRI, Mohakhali, Dhaka. Master seed: Salmonella gallinarumfield strain LRI49 and 9R strain. Master seed: BAU-404 strain This vaccine is administered to chicks and pigeons aged 3 to 7 days. Other rules for use of this vaccine are similar to rules for use of fowl pox vaccine. Follow serial (1). 0.5 ml of vaccine is given s/c. The first dose of vaccine is given in more than 6 weeks old chicken. Second dose of vaccine should be given after 30 days of initial vaccination. Boostering: Boostering should be done every 6 months interval. Just 1 drop in 1 eye after mixing with 50 cc diluent. It is preserved in-5 to 0˚c up to 6 months and -20˚c up to 1 year. Each vial contains 200 doses vaccine Price: Tk 20.00 per vial. It is preserved in 2 to 8˚C up to 6 months. Each vial contains 200 dose vaccine. Price: Tk 40.00 per vial. It is preserved in 0˚C for up to 6 month. গামটবাটরা ষ্টেকা Fowl cholera vaccine Master strain: Local strain. িাঁস-মুরগীর কটলরা ষ্টেকা Duck plague vaccine িাকটপ্ল্গ ষ্টেকা Master seed: Local strain 1st dose at 10-21 days of age. Boostering: Boostering should be done after 7 days of initial vaccination. Oil-adjuvanted vaccine is administered subcutaneously at 1 mL to poultry 2 months of age or older. Second dose of vaccine should be given after 15 days of initial vaccination. Boostering: Boostering should be done every 6 months interval. (1) Small glass vials contain 100 doses of vaccine. 100 ml DW is mixed with freeze dried vaccine and administered 1 ml intramuscularly in the breast muscle. It is preserved in 2 to 8˚C for 6 months. Each vial contains 1000 doses vaccine and 50 ml diluents. Price: Tk 200.00 per vial. Each vial contains 100 dose vaccine. Price: Tk 30.00 per vial. It is preserved in -20˚c up to 1 year, -5 to 0˚c upto 6 months. It can also be preserved in thermoflask with ice for 1 day. Each vial contains 100 doses vaccine. Price: Tk 30.00 per vial. 293 Ducklings at 3 weeks of age should receive their first vaccination. A booster dose should be given on the 21st day after the first vaccination. Immunity of this vaccine lasts up to six months. So this vaccination should be given after 6 months. Reference: http://lri.gov.bd/site/page/de62cf55-2f6f-495f-b8ea-7072e965280d/- Commercial preparations Vaccines of ACI Animal Health Vaccine name Composition Dose, age Preservation Pack size Never deep freezing. Preserve in 28°C 500 or 1000 doses vial Never deep freezing. Preserve in 28°C 1000 doses vial Never deep freezing. Preserve in 28°C 500, 1000 doses vial List of Live Vaccines CEVAC IBDL Winter field 2512 G61 Strain of Infectious bursal disease virus. Cevac GUMBO L LIBDV strain of Infectious bursal disease virus. CEVAC BI L Hitchner B1 Strain of Newcastle disease virus and Massachusetts B-48 Strain of Infectious bronchitis virus Broiler bird: 1st dose: 7-10 days of age 2nd dose: 1 week later by eye drop/with drinking water. Pullet bird: 1st dose: 7-10 days of age 2nd dose: 1 week later by eye drop/with drinking water. Broiler bird: 1st dose: 7-10 days of age 2nd dose: 1 week later by eye drop/with drinking water. Pullet bird: 1st dose: 7-10 days of age 2nd dose: 1 week later by eye drop/with drinking water. Broiler bird: 1st dose: 1-3 days of age, 2nd dose: 3-4 weeks later eye drop/with drinking water. Pullet bird: 1st dose: 1-3 days of age; 2nd dose: 3-4 weeks later. Booster: 10-12 weeks of age eye drop/with feeding water. 294 Cevac NEW L Cevac FP L La Sota Strain of Newcastle disease virus Fowl Pox Virus Cutter Strain Cevac POXIMUNE AE L Fowl Pox Virus Ges and Avian encephalomyelitis Virus Cevac MD Serotype 1 (Rispens Rispens CVI988) strain of Marek’s Disease Virus Cevac Winter field 2512 GTRANSMUNE 61 Strain of Infectious Bursal Disease Virus which is enveloped by VPI (Virus Protecting Immunoglobulin) Broiler bird: 1 dose: 1-3 days of age 2nd dose: 3-4 weeks later by eye drop/spray/with feeding water. Pullet bird: 1st dose: 1-3 days of age 2nd dose: 3-4 weeks later. Booster: 8 weeks of age with feeding water. 0.01 ml/Chicken once by Wing Web method (Make sure not in blood vessels) at 4-16 weeks of age. 0.01 ml/Chicken once by Wing Web method (Make sure not in blood vessels) at 4-16 weeks of age. 1-3 days age: 0.2 ml S/C st 1 day age: 0.1 ml S/C or I/M Never deep freezing. Preserve in 28°C 500, 1000 doses vial Never deep freezing, Preserve in 28°C Never deep freezing, Preserve in 28°C Preserve it inliquid nitrogen. Never deep freezing, Preserve in 28°C 1000 doses vial 1000 doses vial 2000 doses vial 5000 doses vial List of Killed vaccines Vaccine name Cevac NEW K Cevac ND IBD K Cevac ND IB EDS K Cevac CORYMUNE 4K Composition Dose, Age Preservation Pack size La Sota Strain of Newcastle Disease Breeder and Layer pulletat 12 weeks of age: 0.5 ml S/C or I/M 1000 doses vial La Sota Strain of Newcastle Disease and GP Strain of Infectious Bursal Disease Virus La Sota Strain of Newcastle Disease, Massachusetts 41 Strain of Infectious bronchitis virus and B8/78 Strain of EDS Virus Avibacterium paragallinarum serotypes A, B, C and In breeder and Layer 7-10 days of age or 12-16 weeks of age: 0.5 ml S/C or I/M Never deep freezing, Preserve in 28°C Never deep freezing, Preserve in 28°C Breeder and Layer pullet: At least 12 weeks of age: 0.5 ml S/C or I/M Never deep freezing, Preserve in 28°C 1000 doses vial Breeder and Layer pullet: 8-10 weeks of age: 0.5 ml I/M Never deep freezing, 1000 doses vial 1000 doses vial 295 Cevac CORYMUNE 7K Cevac MULTIMUNE K5 k Cevac REOMUNE 3 k Cevac REPROMUNE 4k Cevac Broiler ND K Salmonella enteritidis strain Avibacterium paragallinarum Serotypes A, B & C, Salmonella enteritidis strain, La Sota Strain of ND Virus, IB Virus of Massachusetts B-48 and B8/78 Strain of EDS Virus 5 isolates of Pasteurella multocida: 1,3,4 & 3x4, 2 isolates 3 strain: Strain S1133 (Tenosynovitis pathotype), Strain 2408 (malabsorption pathotype) and SS 412 (Proventriculitis pathotype) 2 Strains of Reo Virus: S1133 (Tenosynovitis pathotype) & Strain 2408(malabsorption pathotype), La Sota Strain of Newcastle Disease, Luckert strain of Bursal disease, (Holland and M41) strain of Bronchitis disease virus. La Sota Strain of Newcastle Disease, which is homogenized with oil adjuvant & thiomersal as a preservative. Breeder and Layer pullet: 12-16 weeks of age: 0.5 ml I/M Preserve in 28°C Never deep freezing, Preserve in 28°C 1000 doses vial Breeder and Layer pullet: primary vaccination at 7-8 weeks and booster at 1112 weeks of age by subcutaneous injection of 0.5 ml. Breeder and Layer pullet: 12-16 weeks of age: 0.5 ml S/C. Never deep freezing, Preserve in 28°C 1000 doses vial Never deep freezing, Preserve in 28°C 1000 doses vial Breeder and Layer pullet: 12-16 weeks of age: 0.5 ml S/C. Never deep freezing, Preserve in 28°C 1000 doses vial 1-3 days age: 0.1 ml S/C or I/M Never deep freezing, Preserve in 28°C 5000 doses vial Preservation Pack size List of Vector vaccines Vaccine name Composition Dose, Age 296 Vectormune AI Vectorimune NDV Vectorimune FP MG Genetically engineered Marek’s disease vaccine of Serotype 3 (Turkey Herpes virus of HVT) expressing Avian Influenza key protective antigens. Genetically engineered Marek’s Disease vaccine of Serotype 3 (Turkey Herpes Virus) expressing Newcastle key protective antigens. Mycoplasma gallisepticum- S 6 & R strain single gene inserted in nonessential region of Fowl Pox virus and recombination is done of both. Prevent fowl pox and mycoplasma. 1 day of age: 0.2 ml S/C Preserved in Liquid N2 2000 doses vial 1 day of age: 0.2 ml S/C. Preserved in Liquid N2 2000 doses vial Double Pronged Applicator should be inserted in the prepared vaccine in such a way that it fills the opening of the needle properly. 3-5 weeks age: 0.1 ml in Wing Web. (Make sure not in blood vessels, muscle, bones and feather). Never deep freezing, Preserve in 28°C 1000 doses vial Vaccines of Renata Vaccine name Composition Dose, Age Preservation IZOVAC B1 HITCHNER live attenuated Newcastle Disease virus, strain B1 Hitchner: 10^6.5 EID50 in stabilizing solution. Administer by eye drop, spray or via drinking water. First administration: 1 day of age (spray or eye drop). Second administration: 2-3 weeks later. Booster: every 2-3 months in layers or breeders. The amount of water changes according to the age or season. Inject subcutaneously (at the back of the neck) or intramuscularly (pectoral muscles) in breeders and hens. First vaccination at about 28 days of age; booster at 18 weeks, before the laying period. A first vaccination with live vaccine against Newcastle Store at +2/+8°C. (Live vaccine) IZOVAC ND (Inactivated vaccine) Each dose of 0.5 ml of vaccine contains: Inactivated Newcastle Disease virus : 50 PD50 in oil emulsion Do Pack size 1000 doses 1000 doses 297 IZOVAC CLONE (Live vaccine) IZOVAC CORYZA 3 (Inactivated vaccine) IZOVAC LASOTA (Live vaccine) IZOVAC H120 LASOTA (Live vaccine) IZOVAC GUMBORO 2 (Live vaccine) Live attenuated Newcastle Disease virus, strain Clone: 10^6 EID50 in stabilizing solution. Each dose of 0.5 ml of vaccine contains Inactivated cultures of : Haemophilus paragallinarum serotype A : 5x10^9 CFU; Haemophilus paragallinarum serotype B : 5x10^9 CFU; Haemophilus paragallinarum serotype C : 5x10^9 CFU; in oil emulsion Each dose of vaccine contains : Live attenuated Newcastle Disease Virus, strain Lasota : 10^6 EID50 in stabilizing solution. Each dose of vaccine contains : Live attenuated Newcastle Disease Virus strain Lasota : 10^6 EID50; live attenuated Infectious Bronchitis Virus strain Massachusetts H120: 10^3 EID50; in stabilizing solution. Each dose of vaccine contains: Live intermediate Gumboro Disease virus, strain Disease is recommended. DO Do 1000 doses Inject subcutaneously (at the back of the neck) or intramuscularly (pectoral muscles) of breeders and laying hens. First vaccination at 6-8 weeks, booster dose 4 weeks before point of lay. The second vaccination can be done alone or in association with other antigens. Do 1000 doses Administer via drinking water. The vaccine is administered at 21-28 days of age and then every 2-3 months in layers or breeders. The vaccine Izovac B1 Hitchner or Izovac Clone must be administered at 1 day of age as first vaccination. The amount of water changes according to the age or season. Administer in drinking water. The amount of water changes according to the age or season. The vaccine is administred at 21-28 days of age and then every 2-3 months in layers or breeders. The vaccine IZOVAC H120-B1 HITCHNER or IZOVAC H120-CLONE must be administered at 1 day of age as first vaccination. First vaccination: 8-10 days of age via drinking water. Second vaccination: 18-20 days of age via drinking water. Do 1000 doses Do 1000 doses Do 1000 doses 298 Winterfield 53rd passage: 10^3 EID50 in stabilizing solution. IZOVAC GUMBORO 3 (Live vaccine) IZOVAC NDEDS (Inactivated vaccine) Each dose of vaccine contains: Live intermediate plus Gumboro Disease virus, strain Winterfield 2512/90: 10^2.7 EID50 in stabilizing solution. Each dose of 0.5 ml of vaccine contains: Inactivated Newcastle Disease Virus: 50 PD50; Inactivated EDS '76 Virus : 108 EID50 before inactivation; in oil emulsion Third vaccination (breeders): before point of lay via drinking water together with inactivated IBD vaccine. In case of emergency the vaccine can be administered by eyedrop at 1 day of age. The amount of water changes according to the age or season. First vaccination: 8-10 days of age via drinking water. Second vaccination: 18-20 days of age via drinking water. Third vaccination (breeders): 28-32 days of age via drinking water. Fourth vaccination: before point of lay via drinking water together with inactivated IBD vaccine. In case of emergency the vaccine can be administered by eye-drop at 1 day of age. The amount of water changes according to the age or season. Inject subcutaneously (at the back of the neck) or intramuscularly (pectoral muscles) at 18-20 weeks of age before the laying period. A single administration is sufficient to protect the birds against EDS, while in the case of Newcastle Disease, the administration should be preceded by other vaccinations with live or inactivated vaccine, as is usual in the prophylaxis of this infection. Do 1000 doses Do 1000 doses 299 References 1 2 3 4 5 Plumb’s Veterinary Drug Handbook- 7th Edition by Donald C. Plumb, Pharm.D. Handbook of Veterinary Pharmacology by Walter H. Hsu. Saunders Handbook of VETERINARY DRUGS, Small and Large Animal-fourth edition MSD Veterinary Manual (Pharmacology part) https://www.ema.europa.eu/en/documents/mrl-report/marbofloxacin-summary-report-2committee-veterinary-medicinal-products_en.pdf 6 https://actavet.vfu.cz/media/pdf/avb_2009078010155.pdf 7 Textbook of Rabbit Medicine by Frances Harcourt-Brown. 8 Product list of Square Pharmaceuticals Ltd. Agrovet division 9 Product list of Novartis (Bangladesh) Ltd. 10 Product list of Renata Ltd. 11 Product list of Opsonin Pharma 12 Product list of Incepta Pharma 13 Product list of Axon Animal Health 14 Product list of Navana Pharmaceuticals Ltd 15 Product list of Chemist Pharma 16 Product list of super power pharma 17 Product list of FnF 18 Product list of Techno Drugs 19 Product list of Gentry Pharmaceuticals Ltd. 20 Product list of ALBION LABORATORIES LIMITED 21 Product list of BRIDGE PHARMACEUTICALS LIMITED 22 Product list of Al-Madina Pharmaceuticals Limited 23 Product list of BENGAL REMEDIES LTD. 24 Product list of ACI Ltd. 25 Product list of SK+F Pharmaceuticals 26 Product list of Popular Pharmaceuticals Ltd. 27 Product list of ACME Laboratories Ltd. 28 Product list of PHARMA & FIRM 29 গবাহি শু াহখ ও িাঁস মুরহগর ভরাগ প্রহত্টষ ক ষ্টেকােঃ উৎ ািন, সংরক্ষি ও বযবিার হনটিম হশকা-2019; প্রাহিসম্পি গটবষিা প্রহত্ষ্ঠান, মিাখালী, ঢাকা. 30 Vaccines of Indian Immunologicals Limited. 31 Vaccines of Square Pharmaceuticals. 32 Vaccines of Large Animal Marketed by Bengal overseas Ltd. 33 Different Poultry Vaccines marketed by ACI Ltd. 34 Different Poultry Vaccines marketed by Renata Ltd. 35 Different Poultry Vaccines marketed by Novartis Ltd. 36 Different Poultry Vaccines marketed by Incepta Pharma 37 Intas Pharmaceuticals LTD 38 Vaccines of Bioveta 39 Vaccines of Merck Animal Health 40 Trade manual of different companies drug. 41 A Compandium of Veterinary Medicine by Dr. A.K.M. Saifuddin & Dr. Abu Bakar (Ahad) 42 Apps: DIMS, DIMS Vet 300

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