Topic A1：Critically discuss the implications of stem cell therapy in the treatment of ONE
human disease.
The Implication of Stem Cell Therapy in Lymphoma
In 2020, there were 0.98 cases of Lymphoma for every 100,000 people and 23,376 deaths
cause by the disease that were recorded . The trend of incidents is still rising, particularly
those involving women and teenagers. Lymphoma mainly caused by obesity and smoking
but irrelevance with drunk. Once getting lymphoma, the lymph nodes of patients will be
enlarge under their skin and always fell fatigue and order symptoms. However, the
lymphoma can be treated by processing stem cell therapy but there are both advantages
and disadvantages to this approach. Therefore, a critical evaluation of stem therapy in
lymphoma treatment will be showed as follow.
(cite:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097358/#:~:text=Global%20incidenc
e%20of%20Hodgkin%20lymphoma,the%20geographical%20distribution%20of%20incidence
)
To start with, there is a processing of how stem cell therapy cures the lymphoma. The
natural stem cell occurs in the development of embryo that including totipotent cells and
pluripotent cells. They can replace damaged cells in the human body by proliferating and
differentiating into new types of cells.
(Cite: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104807/ )
Autologous stem cell transplantation (ASCT) is used as a treatment approach for
lymphoma. ASCT is typically performed in patients with relapsed or refractory lymphoma
who have undergone salvage chemotherapy. The process involves collecting the patient's
own stem cells and storing them prior to high-dose chemotherapy. After the
chemotherapy, the stored stem cells are infused back into the patient's body to restore the
bone marrow and immune system. ASCT is considered the standard of care for
relapsed/refractory lymphoma and has shown curative potential. It is particularly effective
in aggressive lymphomas, such as high-grade B-cell lymphoma, mantle cell lymphoma, and
T-cell lymphoma.
(ust library: A Review of Autologous Stem Cell Transplantation in Lymphoma)
Advantages:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510902/
The study analyzed 247 patients with aggressive B-cell lymphomas who underwent ASCT
between 2002 and 2019. ASCT was performed on 247 aggressive B-cell lymphoma patients.
After 3 years, PFS and OS rates were 63% and 68% respectively. Relapse occurred in 28% of
patients, with a 4% non-relapse mortality rate at day 100.
Autologous stem cells transplantation can eliminate the risk of graft rejection or graftversus-host disease, a systemic disorder that occurs when the graft's immune cells recognize
the host as foreign and attack the recipient's body cells. which are potential complications
associated with allogeneic stem cell transplantation where stem cells are obtained from a
donor
ASCT allows for a faster recovery of the immune system, reducing the risk of infections that
commonly occur during the period of compromised immunity following high-dose
chemotherapy [1].可以瞬速恢復細胞數量，把幹細胞植入後
(cite: Autologous Stem Cell Transplant in Hodgkin’s
and Non-Hodgkin’s Lymphoma, Multiple Myeloma, and AL Amyloidosis )
（化療之後）
Evaluation:
Disadvantages:
https://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant
high cost and long period
many discomforts symptoms
https://www.cancer.net/navigating-cancer-care/how-cancer-treated/bone-marrowstemcell-transplantation/side-effects-bone-marrow-transplant-stem-cell-transplant
這種幹細胞治療會先化療
化療期間會大大降低免疫細胞的水平
在移植後的恢復期間很容易感染其他病， 所以要用維生素去預防感染，從而間接導致
任何服藥後的不適症狀
再者失去大量細胞，恢復期間患者會覺得乏力很累
（化療期間）