GlobalData Industry Profile Global Pharmaceuticals October 2023 Reference Code: 0199-0372 Publication Date: October 2023 Primary NAICS: 325412 ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 1 Global Pharmaceuticals Industry Profiles 1. Executive Summary 1.1. Market value The global pharmaceuticals market grew by 4.6% in 2022 to reach a value of $1,299.3 billion. 1.2. Market value forecast In 2027, the global pharmaceuticals market is forecast to have a value of $1,639.3 billion, an increase of 26.2% since 2022. 1.3. Geography segmentation Asia-Pacific accounts for 32.7% of the global pharmaceuticals market value. 1.4. Market rivalry The global research-based pharmaceuticals market is dominated by a relatively small number of multinational corporations, alongside smaller firms such as biotech players focused on a small number of new products; generics companies are also present. The presence of large international incumbents, as well as the number of companies operating within the market, increases the level of rivalry. The leading players in the market include Johnson & Johnson, Bayer, Novartis, and Pfizer. The presence of large-scale global competitors and smaller generics companies fighting for each drug's approval in a lucrative market ensures rivalry is strong. 1.5. Competitive landscape The global pharmaceuticals market is dominated by several large multinational corporations such as Johnson & Johnson, Bayer, Novartis, and Pfizer that leverage their financial muscle, brand reputation, and significant research and development investment to gain a competitive edge. These companies also have a widespread geographical presence, meaning that they benefit from the scale of their international operations. Nonetheless, several smaller firms, such as biotech players, that are focused on a small number of new products also influence the market, and the large number of companies operating overall intensifies competition. ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 3 Global Pharmaceuticals Industry Profiles TABLE OF CONTENTS 1. Executive Summary 3 1.1. Market value ................................................................................................................................................3 1.2. Market value forecast ..................................................................................................................................3 1.3. Geography segmentation.............................................................................................................................3 1.4. Market rivalry...............................................................................................................................................3 1.5. Competitive landscape.................................................................................................................................3 2. Market Overview 8 2.1. Market definition .........................................................................................................................................8 2.2. Market analysis ............................................................................................................................................8 3. Market Data 3.1. 4. Market value ..............................................................................................................................................10 Market Segmentation 4.1. 5. 6. 11 Geography segmentation...........................................................................................................................11 Market Outlook 5.1. 10 12 Market value forecast ................................................................................................................................12 Five Forces Analysis 13 6.1. Summary ....................................................................................................................................................13 6.2. Buyer power...............................................................................................................................................15 6.3. Supplier power ...........................................................................................................................................17 6.4. New entrants .............................................................................................................................................19 6.5. Threat of substitutes ..................................................................................................................................21 6.6. Degree of rivalry.........................................................................................................................................23 7. Competitive Landscape 25 7.1. Who are the leading players? ....................................................................................................................25 7.2. What strategies do leading players follow? ...............................................................................................25 7.3. What are the most recent market developments?....................................................................................26 ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 4 Global Pharmaceuticals Industry Profiles 8. Company Profiles 28 8.1. Bayer AG ....................................................................................................................................................28 8.2. Novartis AG ................................................................................................................................................33 8.3. Pfizer Inc.....................................................................................................................................................38 8.4. Johnson & Johnson ....................................................................................................................................42 9. Macroeconomic Indicators 9.1. 10. 47 Country data ..............................................................................................................................................47 Appendix 48 10.1. Methodology..............................................................................................................................................48 10.2. Industry associations..................................................................................................................................49 10.3. Related GlobalData research .....................................................................................................................50 | About GlobalData ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED 51 Page | 5 Global Pharmaceuticals Industry Profiles LIST OF TABLES Table 1: Global pharmaceuticals market value: $ billion, 2017–22 10 Table 2: Global pharmaceuticals market geography segmentation: $ billion, 2022 11 Table 3: Global pharmaceuticals market value forecast: $ billion, 2022–27 12 Table 4: Bayer AG: key facts 28 Table 5: Bayer AG: annual financial ratios 30 Table 6: Bayer AG: key employees 31 Table 7: Bayer AG: key employees Continued 32 Table 8: Novartis AG: key facts 33 Table 9: Novartis AG: annual financial ratios 35 Table 10: Novartis AG: key employees 36 Table 11: Novartis AG: key employees Continued 37 Table 12: Pfizer Inc.: key facts 38 Table 13: Pfizer Inc.: annual financial ratios 39 Table 14: Pfizer Inc.: key employees 40 Table 15: Pfizer Inc.: key employees Continued 41 Table 16: Johnson & Johnson: key facts 42 Table 17: Johnson & Johnson: annual financial ratios 44 Table 18: Johnson & Johnson: key employees 45 Table 19: Johnson & Johnson: key employees Continued 46 Table 20: Global exchange rate, 2018–22 47 ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 6 Global Pharmaceuticals Industry Profiles LIST OF FIGURES Figure 1: Global pharmaceuticals market value: $ billion, 2017–22 10 Figure 2: Global pharmaceuticals market geography segmentation: % share, by value, 2022 11 Figure 3: Global pharmaceuticals market value forecast: $ billion, 2022–27 12 Figure 4: Forces driving competition in the global pharmaceuticals market, 2022 13 Figure 5: Drivers of buyer power in the global pharmaceuticals market, 2022 15 Figure 6: Drivers of supplier power in the global pharmaceuticals market, 2022 17 Figure 7: Factors influencing the likelihood of new entrants in the global pharmaceuticals market, 2022 19 Figure 8: Factors influencing the threat of substitutes in the global pharmaceuticals market, 2022 21 Figure 9: Drivers of degree of rivalry in the global pharmaceuticals market, 2022 23 ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 7 Global Pharmaceuticals Industry Profiles 2. Market Overview 2.1. Market definition The pharmaceuticals market consists of ethical drugs only and does not include consumer healthcare or animal healthcare. Market values have been calculated at ex-factory prices (the value at which manufacturers sell the drugs to distributors). All market data and forecasts are represented in nominal terms (i.e., without adjustment for inflation) and all currency conversions used in the creation of this report have been calculated using constant 2022 annual average exchange rates. For the purposes of this report, the global market consists of North America, South America, Europe, Asia-Pacific, the Middle East, Ghana, Morocco, Nigeria, and South Africa. North America consists of Canada, Mexico, and the United States. South America consists of Argentina, Brazil, Chile, Colombia, Costa Rica, Dominican Republic, Ecuador, Panama, Peru, Puerto Rico, and Uruguay. Europe consists of Austria, Belgium, Bulgaria, Croatia, the Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Luxembourg, Malta, the Netherlands, Norway, Poland, Portugal, Romania, Russia, Slovak Republic, Spain, Sweden, Switzerland, Turkey, Ukraine, and the United Kingdom. Scandinavia comprises Denmark, Finland, Norway, and Sweden. Asia-Pacific consists of Australia, China, Hong Kong, India, Indonesia, Japan, Kazakhstan, Malaysia, Myanmar, New Zealand, Pakistan, the Philippines, Singapore, South Korea, Sri Lanka, Taiwan, Thailand, Turkmenistan, and Vietnam. The Middle East comprises Bahrain, Egypt, Iran, Israel, Kuwait, Oman, Saudi Arabia, and the United Arab Emirates. 2.2. Market analysis The global pharmaceuticals market experienced healthy growth during the historic period. The market experienced healthy growth of 4.6% in 2022, owing to the increased need for drugs and medicines as a result of the rise in acute and chronic diseases. The market is expected to experience healthy growth over the forecast period. The Asia-Pacific region acquired a 32.7% share of the global pharmaceuticals market in 2022. The growth in the global pharmaceuticals market is mainly due to the growth in emerging markets such as China and India. Emerging markets bring new opportunities to pharmaceutical companies. Moreover, according to GlobalData, by 2025, 50% of the new patients in high-growth areas, including diabetes and oncology, are expected to come from BRIC countries. Additionally, the increasing population of people aged 65 and older consumes more medical solutions than younger people and is more susceptible to chronic diseases such as ALS, which weakens muscles in the elderly, and heart failure. For instance, according to GlobalData, the population aged above 65 years in China increased by 3.8% in 2022 from the previous year. The global pharmaceuticals market had total revenues of $1,299.3 billion in 2022, representing a compound annual growth rate (CAGR) of 5.5% between 2017 and 2022. In comparison, the Asia-Pacific and US markets grew with CAGRs of 9.1% and 4.1%, respectively, over the same period to reach respective values of $424.4 billion and $408.0 billion in 2022. ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 8 Global Pharmaceuticals Industry Profiles The growth of the pharmaceuticals market in recent years can be partly attributed to rising GDP, increased specialty drug innovation, and increasing access to medicines. For instance, the real GDP annual growth rate of China in 2022 stood at 3%, according to in-house research. Moreover, specialty medications are frequently shielded by patents, which give the manufacturer exclusive rights for a predetermined amount of time. In contrast, when these patents expire, generic versions of the medications may be released on the market, increasing competition and possibly driving down prices. Pharmaceutical businesses lessen the effects of patent expirations and continue market expansion by consistently inventing and creating new specialty pharmaceuticals. Taking these factors into consideration, the global pharmaceuticals market is poised for sustained growth. The performance of the market is forecast to decelerate, with an anticipated CAGR of 4.8% over 2022–27, which is expected to drive the market to a value of $1,639.3 billion by the end of 2027. Comparatively, the Asia-Pacific and US markets will grow with CAGRs of 7.6% and 2.6%, respectively, over the same period to reach respective values of $613.1 billion and $463.0 billion in 2027. The global pharmaceuticals market is poised for sustained growth in the future, propelled by a proactive embrace of emerging technologies, digitalization to enhance operational efficiency, and government support and funding. The Indian Ministry has launched a "Strengthening of Pharmaceutical Industry (SPI)" scheme, totaling INR5 billion, to support existing pharma clusters and MSMEs in improving productivity, quality, and sustainability. FDI is allowed up to 100% through the automatic route for greenfield pharmaceutical projects and up to 74% for brownfield pharmaceutical projects through the automatic route and government approval. Moreover, in August 2023, the government also announced a scheme to promote research and innovation in the pharmaceutical medical technology sector, estimated to cost INR50 billion ($636.1 million), to reduce the country's dependence on imports of orphan drugs and medical devices. The government will select nine manufacturers of drugs and medical devices to conduct research in six priority areas. ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 9 Global Pharmaceuticals Industry Profiles 3. Market Data 3.1. Market value The global pharmaceuticals market grew by 4.6% in 2022 to reach a value of $1,299.3 billion. The compound annual growth rate of the market in the period 2017–22 was 5.5%. Table 1: Global pharmaceuticals market value: $ billion, 2017–22 Year $ billion € billion % Growth 2017 994.6 943.9 2018 1,114.3 1,057.4 12.0% 2019 1,135.4 1,077.4 1.9% 2020 1,184.2 1,123.8 4.3% 2021 1,241.7 1,178.3 2022 1,299.3 1,233.0 4.9% 4.6% CAGR: 2017–22 Source: GlobalData 5.5% © GlobalData Figure 1: Global pharmaceuticals market value: $ billion, 2017–22 Source: GlobalData ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 10 Global Pharmaceuticals Industry Profiles 4. Market Segmentation 4.1. Geography segmentation Asia-Pacific accounts for 32.7% of the global pharmaceuticals market value. United States accounts for a further 31.4% of the global market. Table 2: Global pharmaceuticals market geography segmentation: $ billion, 2022 Geography 2022 % Asia-Pacific 424.4 32.7 United States 408.0 31.4 Europe 353.5 27.2 Middle East 21.3 Rest of the World 92.1 1.6 7.1 1,299.3 100% Total Source: GlobalData © GlobalData Figure 2: Global pharmaceuticals market geography segmentation: % share, by value, 2022 Source: GlobalData ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 11 Global Pharmaceuticals Industry Profiles 5. Market Outlook 5.1. Market value forecast In 2027, the global pharmaceuticals market is forecast to have a value of $1,639.3 billion, an increase of 26.2% since 2022. The compound annual growth rate of the market in the period 2022–27 is predicted to be 4.8%. Table 3: Global pharmaceuticals market value forecast: $ billion, 2022–27 Year $ billion € billion % Growth 2022 1,299.3 1,233.0 4.6% 2023 1,363.3 1,293.7 4.9% 2024 1,432.1 1,359.0 5.0% 2025 1,505.7 1,428.9 5.1% 2026 1,569.2 1,489.1 2027 1,639.3 1,555.6 4.2% 4.5% CAGR: 2022–27 Source: GlobalData 4.8% © GlobalData Figure 3: Global pharmaceuticals market value forecast: $ billion, 2022–27 Source: GlobalData ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 12 Global Pharmaceuticals Industry Profiles 6. Five Forces Analysis The pharmaceuticals market will be analyzed taking pharmaceutical manufacturers as players. The key buyers will be taken as hospitals, pharmacies, and government healthcare programs, and providers of active pharmaceutical ingredients, appropriate manufacturing/laboratory equipment and clinical trial services as the key suppliers. 6.1. Summary Figure 4: Forces driving competition in the global pharmaceuticals market, 2022 Source: GlobalData © GlobalData The global research-based pharmaceuticals market is dominated by a relatively small number of multinational corporations, alongside smaller firms such as biotech players focused on a small number of new products; generics companies are also present. The presence of large international incumbents, as well as the number of companies operating within the market, increases the level of rivalry. The leading players in the market include Johnson & Johnson, Bayer, Novartis, and Pfizer. The presence of large-scale global competitors and smaller generics companies fighting for each drug's approval in a lucrative market ensures rivalry is strong. Buyer power is strengthened by the oligopoly status and price control policies of state and private sector institutions that are ultimately the major purchasers of drugs. Obtaining high-quality materials, equipment, personnel, and thirdparty clinical testing services is vital to the business of pharmaceutical companies. The pharmaceuticals market is characterized by strong buyer power, with the ease of market entry strongly affected by legal and regulatory frameworks. Major suppliers to the pharmaceutical market are manufacturers of active pharmaceutical ingredients (APIs), which form a sub-sector of the chemical industry. Some of the leading suppliers of raw ingredients in the global market include BASF, Bayer, and DuPont de Nemours (formerly DowDuPont), which produce key inputs such as disintegrants, glidants, and diluents. New entrants must satisfy regulators that their products are safe and effective. Non-drug therapies are substitutes for many pharmaceuticals. In addition, research-based drugs that are no longer protected by patents may be substituted by cheaper generic copies, with many 'blockbuster' drugs coming off patent in the next few years, giving the market a so-called 'patent cliff' to negotiate. ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 13 Global Pharmaceuticals Industry Profiles There are several substitutes for pharmaceuticals considered in this report. Patients may choose traditional remedies. Physicians may opt for non-drug treatments if they consider them more appropriate. Successful drugs coming off patent also allow buyers to purchase generic drugs. This risk is, however, mildly reduced, as not all drugs have an effective generic replacement, meaning the original can be sold unhindered by competitors even after the patent ends. In some instances, it is even the original company that produces the generic to try to prevent generic makers from smuggling into the market. ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 14 Global Pharmaceuticals Industry Profiles 6.2. Buyer power Figure 5: Drivers of buyer power in the global pharmaceuticals market, 2022 Source: GlobalData © GlobalData Pharmaceutical manufacturers may sell to drug wholesalers, which then sell on to pharmacies or healthcare institutions such as hospitals. Mature markets are facing rising healthcare costs due to aging populations, and governments are therefore putting increasing pressure on prices. Conversely, emerging markets are growing in potential and becoming more important for manufacturers. Some of the largest buyers in the global market include various National Health Services, CVS Corporation, Cigna, and Walgreens, all of which have strong financial muscle and purchase large quantities of drugs. Some independent pharmacies exist, but they often operate on a small scale and supply isolated communities. Except for OTC and similar drugs, prescriptions are generally required to obtain pharmaceutical products. The marketing of prescription drugs by their manufacturers is therefore largely directed at medical practitioners, with whom they wield a significant influence. In fact, with the notable exception of the US, advertising such products directly to consumers is usually illegal. Depending on the medical condition, there may be several different drug treatments available, and product differentiation in these cases weakens buyer power. Such differentiation can include efficacy, ease of use, side effects, and cost-effectiveness. The move towards genetic and genomic research, giving rise to the possibility of personalized medicine, is also likely to decrease buyer power. Conversely, where generic equivalents to a branded drug exist, differentiation is decreased and buyer power is enhanced. The primary source of funds for drug purchases is, in most cases, a public or private-sector health insurer or similar body. These may fund purchases directly, as does the National Health Service in the UK, or they may reimburse some or all of an end-user’s initial purchase. This increases buyer power. Not only can such large purchasers exert monopsony market power, but it is also very common for them to use one or more specific price control strategies. Governments may simply set drug prices directly, in which case it becomes illegal to sell at a different price. Where governments are responsible for the reimbursement of consumers, they may set a very low reimbursement price for new or existing drugs on the market. Reference price regimes, in which reimbursement levels are set by comparison of the price of a drug in peer-group countries and/or therapeutic categories, are common. Where a therapeutic category contains generics, the effect may be to push down the reference price for on-patent drugs in the same category. A similar effect can occur when peer group countries have lower per capita incomes than the country making the comparison. ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 15 Global Pharmaceuticals Industry Profiles Several countries, such as the US and Germany, are moving towards a value-based pricing system in which the price of drugs is based on health outcomes rather than development costs. Price, volume, or profit controls may exist. These set a limit to the volume of a drug that may be sold in the country or to the amount of profit a drug company can make, beyond which manufacturers must offer either compensatory payments to the government or price reductions. Import tariffs are also used to encourage manufacturers to locate in a given economy. Such systems may be regarded as market distortions. However, where they are in force, it is because policymakers consider that the social benefits of lower-cost drugs, such as improved access to healthcare, outweigh the social harms, such as a potential reduction in pharmaceutical companies’ ability to invest in R&D. Price sensitivity is becoming a key issue for new drugs. However, this is not because healthcare providers are unwilling to pay high prices for new and innovative therapies, but because of the growing media backlash against drug companies charging hundreds of thousands, sometimes millions, of dollars for advanced therapy treatment regimens. Vertex Pharmaceuticals exemplifies this debate in the US and UK: having developed multiple therapies for cystic fibrosis, a rare and incurable genetic disease, the company is in an ongoing battle with reimbursement agencies regarding the pricing of its latest therapy—$293,000 per patient. Factors weakening buyer power include the high importance of pharmaceuticals in healthcare. This is obvious in systems such as the US, where many individuals are personally responsible for significant co-pays and private insurance premiums. But even in the UK, where the National Health Service is funded entirely by taxation and free at the point of use, it would be politically hazardous for a government to neglect healthcare. The COVID-19 pandemic has made this issue ever more important as governments around the world demand vaccinations and other treatments to help control the spread of the virus. Although the ultimate users (individual patients, i.e., voters) of pharmaceuticals interact with the pharmaceutical market through the political system rather than a straightforward value chain, they still have a significant impact on the purchasing process. Overall, buyer power is assessed as moderate. ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 16 Global Pharmaceuticals Industry Profiles 6.3. Supplier power Figure 6: Drivers of supplier power in the global pharmaceuticals market, 2022 Source: GlobalData © GlobalData Major suppliers to the pharmaceutical market are manufacturers of active pharmaceutical ingredients (APIs), which form a sub-sector of the chemical industry. Some of the leading suppliers of raw ingredients in the global market include BASF, Bayer, and DuPont de Nemours (formerly DowDuPont), which produce key inputs such as disintegrants, glidants, and diluents. Several leading pharmaceutical companies have major investments in fine chemical manufacturing, providing them with a degree of self-sufficiency, which reduces supplier power to some extent. APIs are supplied on a contractual basis, so pharmaceutical companies are likely to risk high switching costs if they consider taking their business elsewhere. In turn, pharmaceutical companies employ sourcing managers to minimize costs and mitigate supplier power. The development of new therapeutic agents requires the sourcing of newer APIs, for which chemical manufacturers can charge pharmaceutical companies higher prices. If the novel drug successfully reaches the market, the supplier of the API can make a large amount of money. Market players tend to purchase their raw materials from numerous suppliers, reducing their reliance on any particular company. In general, laboratory equipment and chemicals show little differentiation between suppliers, with customers utilizing a high degree of choice to obtain the best quality and cost relationship, reducing supplier power. However, there are instances where specialized facilities or raw materials are required, such as the sterile processing of biological materials. In such cases, supplier power is much stronger. It is unlikely that suppliers would forward-integrate into the pharmaceutical market; however, their capabilities in chemical synthesis make them ideal candidates for forward integration into the manufacture of generic drugs. Over recent years, larger pharmaceutical companies have turned to producing their chemicals in a bid to enhance profits; however, smaller companies lack the resources required to do this and remain reliant on API manufacturers. For instance, Sanofi announced its plans to launch a new standalone business unit called EUROAPI in the recent past. The company intends to become the largest API producer in the European region with the introduction of a new unit. Pharmaceutical companies will likely be keener to backward integrate into APIs because those ingredients are essential to producing the final generic drug and are therefore going to be most in demand. In September 2022, the Department of Health and Human Services announced investment plans of $40 million to expand the role of biomanufacturing for active pharmaceutical ingredients (APIs), antibiotics, and the crucial raw materials required to produce vital medications and combat pandemics. However, several API suppliers in the US ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 17 Global Pharmaceuticals Industry Profiles market could weaken supplier power by providing pharmaceutical companies with a greater ability to shop around and select suppliers based on factors such as price. The Indian pharmaceuticals market has witnessed considerable growth in recent years; however, the country relies heavily on the import of APIs to manufacture pharmaceutical goods and meet rising demand. In response, the Indian government announced plans in recent years to implement a production-linked incentive scheme for the promotion of domestic manufacturing key starting materials (KSMs), drug intermediates (DIs), and APIs. Under the scheme, the government planned to invest in new machinery and equipment, research facilities, and the building of new production plants. India has started manufacturing 38 active pharmaceutical ingredients (APIs) in the last 1.5 years, reducing import dependency under the production-linked incentive (PLI) scheme, according to the Union Health Ministry. It is common for pharmaceutical companies to outsource their drug testing and clinical trials to third-party test service providers. Given the importance of these trials for regulatory approvals, these service providers are also important suppliers. Overall, supplier power is moderate. ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 18 Global Pharmaceuticals Industry Profiles 6.4. New entrants Figure 7: Factors influencing the likelihood of new entrants in the global pharmaceuticals market, 2022 Source: GlobalData © GlobalData Regulation and legal frameworks can affect the ease of market entry in several ways. Firstly, a company wishing to market its products must demonstrate that its drugs are safe and effective, to the satisfaction of the national regulator. Examples of regulators include the Health Sciences Authority in Singapore, India’s Drug Standard Control Organization, and the Pharmaceutical and Food Administration (FDA) in the US. A start-up company that intends to develop an entirely new biotech drug will need significant up-front investment, often from venture capital companies, and this must be available for the time it takes to develop and test the product. In Singapore, the National Medical Research Council (NMRC) offers up to $250,000 in funding for the development of an innovative healthcare-related product up to the point of commercialization. This could provide an opportunity for smaller players with something new to offer to gain entry to the market by assisting with the high costs that act as a barrier. Similarly, the Dutch government offers an Ambitious Entrepreneurship Action Plan, in which a total of EUR75 million ($86 million) of funding has been set aside for entrepreneurs and start-up companies with innovative contributions across a range of industries. Meeting regulatory requirements is time-consuming; it can take 10 to 15 years to bring a drug to market. According to the Pharmaceutical Research and Manufacturers of America (PhRMA), out of 5,000 to 10,000 screened compounds, only 250 enter preclinical testing, of which only five enter human clinical trials, and finally just one will be approved. In addition to investing a significant amount in research and development, manufacturers also spend substantial costs on marketing, which further increases the capital required by new entrants. On the other hand, entering a specific country market with an existing drug is likely to be easier, provided the licensing authority there is satisfied. A further regulatory barrier to entry is the use of restrictive formularies: for a specific therapeutic category, only certain drugs may be listed as preferred. This does not mean that non-formulary alternatives are unsafe or ineffective. Rather, they can only be prescribed in special circumstances with prior approval from the relevant authority or with more substantial co-payments from the patient. The potential market for non-formulary drugs will therefore be smaller than the size of the therapeutic class market might imply. Due to the relatively low manufacturing costs of small molecules, patent protection is the major barrier to entry for new entrants into the market. The intensity of competition can result in significant legal action around the time a major drug reaches the end of its patent life, particularly for ‘blockbuster’ drugs that sell more than $1 billion a year. Secondary patents covering new alterations in the drug formulation, dosing regimens, or methods of administration ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 19 Global Pharmaceuticals Industry Profiles are usually pursued, prompting litigation between major pharmaceutical and generic companies. Indeed, it is usually worthwhile for a manufacturer to spend millions in legal fees to delay the launch of a new generic product by several weeks, due to the profitability of major blockbuster drugs. The nature and strength of intellectual property protection are dependent on the specific market; however, compliance with international IP legislation is improving in developing markets, particularly where these markets are shifting to knowledge-led economies. New entrants will also have to recruit specialists in the field to develop and produce innovative medications. Researchers often have a bachelor’s degree in chemistry or a related field; potential employees with qualifications of this nature often command higher salaries, which could prove to be a barrier for new entrants. Entry into markets around the world varies significantly, but there is an overall trend of reducing opportunities as governments seek to lower drug prices, particularly for generic drugs. Even countries such as South Korea, which has an aging population, have limited prospects for new entrants because of government pressure on companies to reduce prices. Developing markets are improving regarding regulation, making the task of entering the market for large foreign companies easier. In markets with the wealthiest healthcare systems, getting access is difficult. Regulatory authorities impose sets of rules that demand the highest testing standards and are motivated to keep prices as low as possible. Current players in the generics market, with whom new entrants must compete, are well-established companies that benefit from scale economies. These include leading companies such as Teva and Sandoz (a division of Novartis). Barriers to entry for a generics company will depend on factors such as the expiration of patents on those drugs it intends to replicate and the likelihood that the patent holder will protect its market position by offering a similar drug under a new or extended patent. Also, laws defending intellectual property vary from country to country. In some cases, patent law may be undeveloped. In others, governments may explicitly prioritize public health needs over private intellectual property rights. For example, India did not allow drugs to be patented until 2005 (in line with WTO requirements) and currently only grants patents to completely new drugs rather than improvements to existing products. Overall, the barriers to market entry are high, and the threat of new entrants is weak. ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 20 Global Pharmaceuticals Industry Profiles 6.5. Threat of substitutes Figure 8: Factors influencing the threat of substitutes in the global pharmaceuticals market, 2022 Source: GlobalData © GlobalData There are several substitutes for pharmaceuticals considered in this report. Patients may choose traditional remedies. Physicians may opt for non-drug treatments if they consider them more appropriate. Successful drugs coming off patent also allow buyers to purchase generic drugs. Switching costs for patients here are relatively low. However, they may be more significant for the ultimate buyers, the healthcare providers. For example, suppose a national healthcare system reviewed the clinical evidence and decided that a chronic condition that had been treated by drugs taken for the patient’s lifetime could be treated by a simple surgical procedure. This would be a beneficial and cheap alternative. However, it might require more surgical teams to be trained and more operating theaters to be made available, which the healthcare system would also need to fund. These would constitute switching costs. The main substitutes for branded drugs are generics and biosimilars (also known as follow-on biologics). Manufacturers of generics can offer the same drug at a much lower price, as they rely on the safety and efficacy data provided by the innovator product, and they therefore do not have to conduct costly clinical trials. According to the NHS, 81% of all drugs used in primary care in England are prescribed generically to generate savings for the country’s health system. The Australian government has aimed to increase the prescription of generic and biosimilar medicines and is undertaking several initiatives to increase healthcare professionals' and consumers' awareness of and confidence in the use of biosimilar medicines. China’s National Health Commission has also been encouraging the production of generic alternatives in recent years, increasing the threat of this substitute. For example, China is in talks with Pfizer to secure a license allowing domestic drugmakers to manufacture and distribute a generic version of Pfizer's COVID-19 antiviral drug Paxlovid in China. This follows a licensing arrangement with the U.N.-backed Medicines Patent Pool, which allows 35 generic drugmakers, including five Chinese firms, to produce cheap versions of Paxlovid for 95 poorer countries. Overall, the push to use generic drugs where possible in many countries around the world increases the threat of this substitute. Despite the growth of conventional medicine, particularly in the Asia-Pacific region, old ideas about the supposed healing qualities of rhino horn and parts of other animals remain embedded in a large number of people. The continued use of treatments that predate modern medicine is a threat to the pharmaceutical market. Increasing demand for herbal medicines and alternative drugs is expected to offer substantial opportunities to substitute for the pharmaceutical market. Alternative medicines and treatments are also popular in other countries in the region, such as Japan, Singapore, and South Korea. Chinese traditional medicine and Ayurvedic medicine are two of the oldest ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 21 Global Pharmaceuticals Industry Profiles systems of medicine in the world and have been practiced in those regions for thousands of years. They are both extremely popular all over the Asia-Pacific region, and many countries have adopted their take on the teachings. Although there has been a backlash against these products, they have been retained within many systems in part because of their effectiveness as placebo therapy. Medical practitioners consider prescribing a ‘pure’ placebo unethical, and therefore alternative medicines continue to be a prescribed substitute product in many healthcare systems. Counterfeit drugs are also an issue in Russia. A report by Deutsche Welle estimated that some 50% of drugs sold through online pharmacies could be fake, and as many as 27% of drugs on Russian pharmacy shelves are fake. However, the Russian government has enacted several laws, including a 12-year prison sentence and a large fine for counterfeiting or falsifying medicines. The threat of substitutes is assessed as moderate. ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 22 Global Pharmaceuticals Industry Profiles 6.6. Degree of rivalry Figure 9: Drivers of degree of rivalry in the global pharmaceuticals market, 2022 Source: GlobalData © GlobalData The global research-based pharmaceuticals market is dominated by a relatively small number of multinational corporations, alongside smaller firms such as biotech players focused on a small number of new products; generics companies are also present. The presence of large international incumbents, as well as the number of companies operating within the market, increases the level of rivalry. The leading players in the market include Johnson & Johnson, Bayer, Novartis, and Pfizer. A further trend is big players' swapping key asset portfolios. The practical benefit is reducing overall costs by increasing specialization, therefore eliminating research in less profitable areas. The downside is the possibility that drugs will be produced by fewer companies, decreasing the chance of breakthroughs. Large companies often lose revenue due to the expiration of patents and are increasingly motivated to acquire smaller companies that have strong revenue potential due to innovative products. In July 2023, Novartis acquired DTx Pharma, a preclinical biotechnology company that focuses on oligonucleotide therapeutics, for around $1 billion. The acquisition will allow Novartis to develop life-changing medicines for patients with neuromuscular diseases and nervous system disorders, strengthen its neuroscience pipeline, and expand its capabilities in RNA therapeutics. Therefore, acquisitions are common in this particular market and are a key way for companies to establish a competitive edge. Research-based pharmaceutical companies are similar to media companies in that they rely on initially creating valuable intellectual property at a high cost, which can then be used to create mass-produced products at a relatively low cost. The ability of generics companies to be profitable while selling the same molecule at a much lower price than the originator, following patent expiration, shows that establishing high-quality manufacturing processes is not prohibitively costly. A secondary effect of this is that it is relatively easy for research-based companies to expand output, for example, through licensing agreements with other companies, without the need to scale up their production facilities. Given the increasing linkages between regulatory authorities and the greater likelihood of a drug being approved in multiple locations, this tends to boost rivalry. The Asia-Pacific is the largest pharmaceutical market globally, accounting for 32.7% of the global market’s total value in 2022, while the US and European regions accounted for 31.4% and 27.2%, respectively. The US continues to be a good market for new drugs; its consistent growth and sheer size have made it an attractive prospect for doing business. However, growth in the US market is anticipated to decelerate somewhat over the next five years. Comparatively, the Chinese market, which is the largest in the Asia-Pacific region and accounted for 50.2% of total ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 23 Global Pharmaceuticals Industry Profiles Asia-Pacific value in 2022, is expected to grow over the forecast period. Therefore, the global market could see a shift towards production and manufacturing in China, intensifying rivalry if market activity becomes more concentrated in this geography. Overall, the degree of rivalry is strong. ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 24 Global Pharmaceuticals Industry Profiles 7. Competitive Landscape The global pharmaceuticals market is dominated by several large multinational corporations such as Johnson & Johnson, Bayer, Novartis, and Pfizer that leverage their financial muscle, brand reputation, and significant research and development investment to gain a competitive edge. These companies also have a widespread geographical presence, meaning that they benefit from the scale of their international operations. Nonetheless, several smaller firms, such as biotech players, that are focused on a small number of new products also influence the market, and the large number of companies operating overall intensifies competition. 7.1. Who are the leading players? Johnson & Johnson Johnson & Johnson (J&J) is one of the leading companies in the global pharmaceutical market. The company develops, manufactures, and markets pharmaceuticals, consumer healthcare products, and medical devices. It offers pharmaceuticals in the therapeutic areas of immunology, oncology, neuroscience, infectious diseases and vaccines, pulmonary hypertension, cardiovascular, and metabolism. The company is headquartered in the US and has a business presence across various regions, including Europe, Asia-Pacific, Africa, and the Western Hemisphere (excluding the US), allowing it to benefit from the scale of its international operations. Bayer Bayer AG is a Germany-based life science company that develops, manufactures, and commercializes products for human health and agriculture. It offers medicines for various diseases and technologies, including cardiovascular diseases, cancer, hematology, and ophthalmology. It develops, produces, and sells pharmaceutical, agricultural, and polymer products. The company classifies its business into three segments: pharmaceuticals, consumer health, and crop science. The company markets its healthcare and crop protection products through wholesalers, pharmacies, hospitals, and retailers, with subsidiaries in Asia-Pacific, Europe, North America, Latin America, Africa, and the Middle East. Novartis Novartis AG is a Swiss healthcare company that specializes in the discovery, development, manufacture, and marketing of prescription and generic pharmaceutical products and eye care products. It offers drugs for various diseases, including cancer, cardiovascular, dermatological, neurological, ophthalmic, respiratory, hematologic, solid tumors, immune disorders, and infections. The company conducts research through the Novartis Institutes for BioMedical Research (NIBR) and operates through subsidiaries and offices worldwide. Pfizer Pfizer is a US-based biopharmaceutical company that develops, manufactures, and commercializes products for various conditions like cardiovascular, metabolic, pain, women's health, cancer, inflammation, immune disorders, and rare diseases. The company sells its products through wholesalers, retailers, hospitals, clinics, government agencies, and pharmacies. Pfizer has manufacturing facilities in India, China, Japan, Ireland, Italy, Belgium, Germany, Singapore, and the US and distributes its products in North America, South America, Asia-Pacific, Australia, Europe, Africa, and the Middle East. 7.2. What strategies do leading players follow? Johnson & Johnson expands its operations and improves its presence through contracts and agreements. For instance, in February 2023, Johnson & Johnson (China) Investment announced the renewal of the partnership with Zhongchao to further strengthen cooperation in the field of innovative medicine and health. This extended partnership helps in providing online professional medical training and education services for medical workers for their diagnostic and therapeutic capabilities. This helps improve the accessibility and affordability of medical and ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 25 Global Pharmaceuticals Industry Profiles health services and provides quality medical resources. In January 2023, the company, along with Walmart, teamed up with CareSource to launch a new program supporting black maternal health across the state of Georgia. This program aims at four factors: self-care support, high-touch pregnancy care, and healthcare professional education. The agreement helps expand communities in the future and provides quality care to our customers and patients. In October 2022, the company reached a cooperation agreement with Mersana Therapeutics to jointly develop three new-generation ADC drugs. The company and Mersenna Research target candidates during preclinical development. The company offers proprietary antibodies, whereas Mersana provides its Dolasynthen platform to help find new ADC product candidates. After the preclinical stage, J&J handles the clinical development and commercialization of the product. The agreement helps in the introduction of new ADC drugs from the company and increases financial stability. Pfizer's ability to receive approval for its products will enable it to enhance operations and strengthen its market presence. In May 2023, the company announced that the U.S. Food and Drug Administration had approved ABRYSVO for the prevention of respiratory syncytial virus (RSV) in older adults. The approval of this product marks a significant milestone in Pfizer's dedication to addressing the substantial burden of RSV (Respiratory Syncytial Virus) among higher-risk populations, including older adults. In March 2023, the company’s ZAVZPRE (zavegepant) Migraine Nasal Spray received approval from the US Food and Drug Administration (FDA) for the acute treatment of migraine. ZAVZPRET offers an alternative treatment option for people with migraines to gain relief and get back to their daily lives. This increases the company’s migraine franchise by supporting billions of people worldwide. In February 2023, the company’s CIBINQO (abrocitinib) received approval from the US Food and Drug Administration (FDA). CIBINQO was approved to be used in the treatment of refractory, moderate-tosevere atopic dermatitis (AD). The product offers potential relief for young atopic dermatitis patients in need and their families. This presents the company with fresh prospects in adolescent products. In January 2023, the company secured approval from the Therapeutic Goods Administration for the bivalent COVID-19 vaccine. Novartis views acquisitions and divestments as a major part of its growth. These initiatives are intended to supplement Novartis’s growth and help expand its business and territorial coverage. In September 2022, the company planned to invest $300 million in next-generation biotherapeutics. The investment will be $100 million for the NIBR biologics center, $110 million for the clinical manufacturing and technical capabilities improvement of Biocampus in Slovenia, and $60 million for Schaftenau in Austria. In June 2022, the company announced plans to invest in the expansion of RLT production capabilities in both Millburn and Ivrea as well as building a new radioligand manufacturing facility in Indianapolis, Indiana. In the same month, the company invested $250 million over five years to research and develop new treatments for neglected tropical diseases and malaria. In this investment, $100 million is for advanced research and development for Chagas disease, leishmaniasis, dengue fever, and cryptosporidiosis, whereas $150 million is for next-generation antimalarials and a new formulation. In the same month, the company and other investors invested $119 million in AllAdapt Immunotherapeutics. This investment helps in the improvement of ADP101, an FDA-approved therapy to treat food allergies in patients. Bayer's regulatory approvals and product launches have enhanced its outreach and financial performance. In March 2023, the company and Orion received the Chinese National Medical Products Administration's approval for the oral androgen receptor inhibitor (ARi) Nubeqa (darolutamide) in combination with docetaxel for the treatment of patients with metastatic hormone-sensitive prostate cancer. Nubeqa has already received approval in China for treating high-risk patients diagnosed with non-metastatic castration-resistant prostate cancer (nmCRPC) to prevent the development of metastatic disease. This will help the company cater to more patients in the Chinese region. 7.3. What are the most recent market developments? In August 2023, Chinook Therapeutics merged with Novartis AG, acquiring Chinook for $3.2 billion in cash. The merger represents a premium of 83% to Chinook's 60-day volume-weighted average stock price and 67% to its closing price in June 2023. Chinook shareholders will receive contingent value rights (CVRs) for up to $4 per share upon future regulatory milestones for its lead product candidate, atrasentan. The total consideration, including the CVRs, is estimated to be around $3.5 billion. The transaction has been approved unanimously by both companies' boards of directors. ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 26 Global Pharmaceuticals Industry Profiles In July 2023, Novartis acquired DTx Pharma, a preclinical biotechnology company that focuses on oligonucleotide therapeutics, for around $1 billion. The acquisition will allow Novartis to develop life-changing medicines for patients with neuromuscular diseases and nervous system disorders, strengthen its neuroscience pipeline, and expand its capabilities in RNA therapeutics. The Falcon platform enables the delivery and activity of small interfering RNA therapeutics to tissues beyond the liver. In March 2023, Pfizer agreed to acquire Seagen for $43 billion. The acquisition helps in the expansion of the company’s oncology product portfolio. Its major products include Padcev for the treatment of bladder cancer and other ADCs. Seagen’s ADC technology improves innovative cancer care and enhances the existing portfolio across both solid tumors and hematologic malignancies. In October 2022, Pfizer completed the acquisition of Global Blood Therapeutics for $5.4 billion. The acquisition enhances the innovation of the company and improves the potential treatments for people living with sickle cell disease. This acquisition provides an opportunity to transform the lives of patients suffering from sickle cell disease with the help of Global Blood Therapeutics product portfolio and clinical trials. In October 2022, Pfizer completed the acquisition of the US-based Biohaven Pharmaceutical Holding Company. Biohaven is a producer of NURTEC ODT (rimegepant), a migraine therapy used in the treatment of acute migraine and the prevention of episodic migraine in adults. The acquisition helps in the addition of the calcitonin generelated peptide (CGRP) to the Pfizer portfolio, which includes Rimegepant, Zavegepant, and pre-clinical CGRP assets. These products strengthen Pfizer’s innovative internal medicine portfolio. In June 2022, Novartis completed the acquisition of US-based Kedalion Therapeutics and AcuStream technology. The acquisition helps to increase the ophthalmics portfolio of the company and enhances the solution for unmet patient needs in front-of-eye conditions. In February 2022, Novartis acquired the UK-based Gyroscope Therapeutics from Syncona. Gyroscope Therapeutics is used to develop pharmaceutical medicines for rare diseases of the eye to treat diseases of the eye that cause vision loss and blindness. This acquisition enhances the expertise in retinal diseases, gene therapy, and ophthalmology gene therapy of the company. ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 27 Global Pharmaceuticals Industry Profiles 8. Company Profiles 8.1. Bayer AG 8.1.1. Company Overview Bayer AG (Bayer or 'the group') is a life science company that develops pharmaceutical, and chemical products. The company offers prescription and non-prescription medical products, cosmetics, seeds, plant traits, chemical, and biological crop protection products. It also offers products and solutions for the prevention and treatment of diseases in companion and farm animals. The company markets its products under various brands including Adalat, Redoxon, Baytril, Xofigo, Nativo, Serenade, Canesten, Afrin, Cydectin and Seresto brand names. Bayer distributes its products directly to farmers and through pharmacies, retailers, wholesalers, hospitals, veterinarians, supermarkets and drugstore chains. It has business presence in the Asia Pacific, Europe, North America, Latin America, Africa, and the Middle East. The company is headquartered in Leverkusen, Germany. The company reported revenues of (Euro) EUR50,739 million for the fiscal year ended December 2022 (FY2022), an increase of 15.1% over FY2021. In FY2022, the company’s operating margin was 13.8%, compared to an operating margin of 7.6% in FY2021. In FY2022, the company recorded a net margin of 8.2%, compared to a net margin of 2.3% in FY2021. The company reported revenues of EUR10,342 million for the third quarter ended September 2023, a decrease of 6.4% over the previous quarter. 8.1.2. Key Facts Table 4: Bayer AG: key facts Head office: Kaiser-Wilhelm-Allee 1 , Leverkusen, Germany Telephone: 49214301 Fax: 492143066328 Number of Employees: 100873 Website: www.bayer.com Financial year-end: December Ticker: BAYN Stock exchange: XETRA Source: COMPANY WEBSITE 8.1.3. © GlobalData Business Description Bayer AG (Bayer or 'the company) is a manufacturer and distributor of products for preventing, treating, and alleviating diseases. The company develops medicines for cardiovascular diseases, women’s health, cancer, hematology, ophthalmology, and other diseases. As of December 2021, the company operated 374 consolidated companies in 83 countries. The company operates through four reportable segments: Pharmaceuticals, Consumer Health, Crop Science, and All Other segments. The Pharmaceuticals segment offers prescription products for cardiology and women’s healthcare, and specialty therapeutics in the areas of hematology, oncology and ophthalmology. It also includes the radiology business that markets diagnostic imaging equipment together with the necessary contrast agents. It also offers products for curing pulmonary hypertension, bacterial infections, dermatology and diabetes. The segment markets these ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 28 Global Pharmaceuticals Industry Profiles products under Aspirin, yasmin, Xofigo, Adalat, Adempas, Xarelto, Stivarga, Mirena, Levitra brand names. The segment distributes these prescription products through pharmacy wholesalers and hospitals. In FY2022, the Pharmaceutical segment reported revenue of EUR19,252 million, which accounted for 37.9% of the company’s revenue. The Crop Science segment offers prescription products that includes seeds, plant traits, chemical and biological crop protection products and digital for sustainable agriculture. The segment also provides pest and weed control products and services to professional users outside the agriculture industry. It offers products under Acceleron, Adengo, Nativo, Alion, Serenade, Fox, Gaucho, Harness, Maxforce, EsplAnade, FiberMax, Flint, Movento brand names. The company sells these products directly to farmers and through wholesalers and retailer. In FY2022, the Crop Science segment reported revenue of EUR25,169 million, which accounted for 49.6% of the company’s revenue. The Consumer Health segment offers nonprescription (over-the-counter) products, cosmetics, medicines and other self-care solutions in the nutritional, dermatology, allergy, cardiovascular risk prevention, digestive health, foot care, cough and cold and sun protection categories. The company markets these products under Claritin, Aspirin, Aleve, Bepanthen/Bepanthol, Canesten, Afrin, Redoxon, Rennie, and Supradyn. The company sells these products through supermarket and drugstore chains, pharmacies, online retailers and other large retailers. In FY2022, the Consumer Health segment reported revenue of EUR6,080 million, which accounted for 12% of the company’s revenue. The All Other segment offers business support services. It also includes operations of Currenta, which manages and operates the Chempark sites in Krefeld-Uerdingen, Dormagen, and Leverkusen. In FY2021, the All Other segment reported revenue of EUR217 million, which accounted for 0.4% of the company’s revenue. Geographically, the company operates in four regions: Europe, Middle East and Africa; North America; Asia Pacific; and Latin America. In FY2022, the United States with 30.9% of the company’s revenue, followed by Middle East, and Africa (excluding Germany and Switzerland) with 22.4%, Brazil with 10.5%, the Asia Pacific (excluding China) with 10.2%, China with 8.4%, Latin America (excluding Brazil) with 7.8%, Germany with 4.9%, North America (excluding the US) accounted for 3.7% and Switzerland with 1.2%. ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 29 Global Pharmaceuticals Industry Profiles Table 5: Bayer AG: annual financial ratios Key Ratios Growth Ratios Sales Growth % Operating Income Growth % EBITDA Growth % Net Income Growth % EPS Growth % Working Capital Growth % Equity Ratios EPS (Earnings per Share) EUR Dividend per Share EUR Dividend Cover Absolute Book Value per Share EUR Profitability Ratios Gross Margin % Operating Margin % Net Profit Margin % Profit Markup % PBT Margin (Profit Before Tax) % Return on Equity % Return on Capital Employed % Return on Assets % Return on Working Capital % Operating Costs (% of Sales) % Administration Costs (% of Sales) % Liquidity Ratios Current Ratio Absolute Quick Ratio Absolute Cash Ratio Absolute Leverage Ratios Debt to Equity Ratio Absolute Net Debt to Equity Absolute Debt to Capital Ratio Absolute Efficiency Ratios Asset Turnover Absolute Fixed Asset Turnover Absolute Inventory Turnover Absolute Current Asset Turnover Absolute Capital Employed Turnover Absolute Working Capital Turnover Absolute 2018 2019 2020 2021 2022 4.93 -41.49 13.22 -76.89 -25.46 -51.82 18.52 20.50 -1.73 141.36 -4.12 16.17 -4.93 -488.49 -130.54 -356.54 -137.50 -111.85 6.48 120.74 109.53 452.10 -390.48 15.10 109.13 110.88 315.00 84.94 -15.72 3.47 2.80 1.24 49.30 3.33 2.80 1.19 48.10 -1.25 2.00 -0.62 31.07 4.39 2.00 2.20 33.61 8.12 2.40 3.38 39.47 58.14 9.40 4.61 138.88 5.13 3.69 3.33 1.68 43.50 90.60 40.50 59.55 9.56 9.39 147.23 6.55 8.66 4.04 3.24 45.12 90.44 37.10 53.77 -39.06 -25.35 116.32 -41.67 -34.38 -20.20 -8.64 1479.32 139.06 38.60 61.85 7.61 2.27 162.14 4.64 3.03 3.69 0.84 105.61 92.39 34.87 60.84 13.82 8.18 155.34 9.20 10.70 7.81 3.39 262.03 86.18 33.35 1.34 0.86 0.18 1.40 0.94 0.14 0.97 0.67 0.11 1.11 0.72 0.16 1.08 0.69 0.15 0.88 0.78 0.47 0.82 0.71 0.45 1.36 0.97 0.58 1.20 0.96 0.54 1.07 0.80 0.52 0.36 3.57 1.74 1.20 0.35 4.63 0.34 3.43 1.62 1.37 0.42 4.72 0.34 3.42 1.77 1.22 0.52 -37.88 0.37 3.61 1.51 1.29 0.49 13.88 0.41 3.85 1.59 1.44 0.57 18.96 Source: COMPANY FILINGS ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 30 Global Pharmaceuticals Industry Profiles Table 6: Bayer AG: key employees Name Job Title Board Alberto Weisser Director Non Executive Board Andre van Broich Director Non Executive Board Andrea Sacher Director Non Executive Board Antoine Bernet Head Country Division Crop Science Canada Senior Management Asha Hope Head North America Diversity, Equity and Inclusion Senior Management Asha Hope Vice President Senior Management Director Non Executive Board Vice President Communications, Crop Science North America. Senior Management Head Oncology Strategic Business Unit Pharmaceuticals Division Senior Management Global Head, Clinical Development and Operations, Research and Development, Pharmaceuticals Senior Management Claudia Schade Director Non Executive Board Colleen A. Goggins Director Non Executive Board President Consumer Health North America Senior Management Ertharin Cousin Director Non Executive Board Francesco Grioli Director Non Executive Board Frank Lollgen Director Non Executive Board Chief Financial Officer Bayer U.S. Senior Management Barbara Gansewendt Ben Kampelman Christine Roth Christoph Koenen Dave Tomasi Guru Ramamurthy Heike Hausfeld Vice Chairman Executive Board Heike Prinz Chief Talent Officer Senior Management Heike Prinz Labor Director Senior Management Heiko Schipper Head Asia Pacific Senior Management Heiko Schipper President Consumer Health Division Senior Management Heinz Georg Webers Director Non Executive Board Horst Baier Director Non Executive Board Jost Reinhard Head Investor Relations Senior Management Juergen Eckhardt Head Pharmaceuticals Business Development and Licensing, Open Innovation Senior Management Kimberly Mathisen Director Non Executive Board Michael Westmeier Director Non Executive Board Source: COMPANY FILINGS ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 31 Global Pharmaceuticals Industry Profiles Table 7: Bayer AG: key employees Continued Name Job Title Board Head Crop Science, UK, Ireland and Nordics Senior Management Norbert W. Bischofberger Director Non Executive Board Otmar D. Wiestler Director Non Executive Board Paul Achleitner Director Non Executive Board Robert Gundlach Director Non Executive Board Head Crop Science Senior Management Sarena Lin Chief Transformation and Talent Officer Senior Management Sarena Lin Director Labor Senior Management Head US Operations Senior Management Director Non Executive Board President Bayer South Asia Senior Management Head Pharmaceuticals Senior Management Head Oncology Development Oncology Strategic Business Unit Senior Management William N. Anderson Chief Executive Officer Executive Board William N. Anderson Director Executive Board Wolfgang Nickl Chief Financial Officer Senior Management Wolfgang Nickl Head North America Senior Management Yasmin Fahimi Director Non Executive Board Nils Bauer Rodrigo Santos Sebastian Guth Simone Bagel-Trah Simon-Thorsten Wiebusch Stefan Oelrich Tara Frenkl Source: COMPANY FILINGS ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 32 Global Pharmaceuticals Industry Profiles 8.2. Novartis AG 8.2.1. Company Overview Novartis AG (Novartis or ‘the company’) manufactures, and supplies pharmaceutical products, and generic and biosimilar medicines. The company’s product portfolio includes biopharmaceuticals, ophthalmic pharmaceuticals, anti-infectives, retail generics, vision care products, generic medicines and biosimilars. It provides products for cancer, cardio metabolic, cell and gene therapy. Novartis offers its products under Alcon, Azarga, Ciprodex, Cibacen, Cosentyx, Sandoz, Votrient, DAILIES, Clear Care, AIR OPTIX, FreshLook and Lucentis brand names. It also conducts various research and development activities through its Novartis Institutes for BioMedical Research (NIBR). It has operations across Asia, Europe, the US, and Africa. The company is headquartered in Basel, Switzerland. The company reported revenues of (US Dollars) US$51,742 million for the fiscal year ended December 2022 (FY2022), a decrease of 2.1% over FY2021. In FY2022, the company’s operating margin was 17.8%, compared to an operating margin of 22.1% in FY2021. In FY2022, the company recorded a net margin of 13.4%, compared to a net margin of 45.4% in FY2021. The company reported revenues of US$12,092 million for the third quarter ended September 2023, a decrease of 46.9% over the previous quarter. 8.2.2. Key Facts Table 8: Novartis AG: key facts Head office: Lichtstrasse 35 , Basel, Switzerland Telephone: 41613241111 Fax: 41613247826 Number of Employees: 103000 Website: www.novartis.com Financial year-end: December Source: COMPANY WEBSITE 8.2.3. © GlobalData Business Description Novartis AG (Novartis or ‘the company’) is a provider of healthcare products worldwide. It manufactures, develops, and sells eye care, generic and biosimilar medicines, oncology and pharmaceuticals medicines and other products. The company operates through two business segments: Sandoz and Innovative Medicines. Under the Innovative Medicines (IM) segment, the company produces, develops, and sells patented prescription medicines. It performs operations under two business units: Novartis oncology business unit and Novartis pharmaceuticals. The Novartis oncology business unit consists of the global business franchises oncology is responsible in the areas of cancer and hematologic products. Its Novartis pharmaceuticals business unit includes global business franchises ophthalmology, neuroscience, immunology, hepatology and dermatology, respiratory, cardio-metabolic, renal and metabolism, and established medicines. Novartis sell these products under Tasigna, promacta/revolade, Zortress, Voltaren/Cataflam, Jadenu, Zykadia, Travatan Z, Tafinlar + Mekinist, Gilenya, Diovan, Exelon, Galvus, Rydapt, Sandostatin LAR, and Votrient brand names. In FY2022, the Innovative Medicines segment reported revenue of US$41,296 million, which accounted for 81.7% of the total net sales to third parties. Through Sandoz segment, Novartis offers patients and healthcare professional’s generics, anti-infectives and biosimilars under units including biopharmaceuticals, retail generics, and anti-infectives in over 100 countries. It operates manufacturing facilities in Barleben, Holzkirchen and Rudolstadt, Germany; Kundl and Schaftenau, Austria; Ljubljana, Slovenia; and Strykow, Poland. The key products and brands include amoxicillin/clavulanic ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 33 Global Pharmaceuticals Industry Profiles acid (antibiotic); Glatopa (glatiramer acetate injection) 20 mg/mL, multiple sclerosis treatment; zoledronic acid, osteoporosis treatment (retail generics). The company also manufactures classical and semisynthetic macrolides; oral and sterile penicillins; clavulanic acid and mixtures with clavulanic acid (anti-infectives); Omnitrope; Zarzio, Zarxio and Filgrastim Hexal, Zessly, Rixathon, Binocrit and Epoetin alfa Hexal (biopharmaceuticals). In FY2022, the Sandoz segment reported revenues of US$9,249 million, which accounted for 19.3% of the total net sales to third parties. Geographically, the company classifies its operations into three segments: Europe, the Americas, and Asia/Africa/Australasia. In FY2022, the Americas accounted for 42.6% of the total net sales to third parties, followed by Europe (36.5%), Asia/Africa/Australasia (20.9%). ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 34 Global Pharmaceuticals Industry Profiles Table 9: Novartis AG: annual financial ratios Key Ratios Growth Ratios Sales Growth % Operating Income Growth % EBITDA Growth % Net Income Growth % EPS Growth % Working Capital Growth % Equity Ratios EPS (Earnings per Share) USD Dividend per Share USD Dividend Cover Absolute Book Value per Share USD Profitability Ratios Gross Margin % Operating Margin % Net Profit Margin % Profit Markup % PBT Margin (Profit Before Tax) % Return on Equity % Return on Capital Employed % Return on Assets % Return on Working Capital % Operating Costs (% of Sales) % Administration Costs (% of Sales) % Liquidity Ratios Current Ratio Absolute Quick Ratio Absolute Cash Ratio Absolute Leverage Ratios Debt to Equity Ratio Absolute Net Debt to Equity Absolute Debt to Capital Ratio Absolute Efficiency Ratios Asset Turnover Absolute Fixed Asset Turnover Absolute Inventory Turnover Absolute Current Asset Turnover Absolute Capital Employed Turnover Absolute Working Capital Turnover Absolute 2018 2019 2020 2021 2022 6.13 63.08 44.39 63.72 14.85 23.95 5.67 -35.98 -23.15 -6.97 2.03 -79.18 2.62 11.73 11.43 -31.20 13.94 -373.06 5.97 15.14 7.14 197.58 152.32 -558.06 -2.15 -21.32 -8.00 -71.05 -59.79 -46.78 3.79 2.90 1.31 34.01 3.87 3.05 1.27 24.49 4.41 3.39 1.30 25.08 11.12 3.20 3.48 30.27 4.47 3.46 1.29 28.00 70.54 30.84 27.41 239.48 30.63 16.04 12.24 9.05 238.30 69.16 29.75 71.35 18.69 24.13 249.06 18.39 21.15 10.08 8.89 732.74 81.31 29.45 71.14 20.35 16.18 246.51 19.80 14.26 10.72 6.56 -299.82 79.65 28.24 70.81 22.11 45.43 242.58 49.43 35.51 11.51 18.51 75.36 77.89 28.02 71.01 17.77 13.44 244.99 16.18 11.72 10.36 5.58 111.42 82.23 27.42 1.20 0.97 0.45 1.04 0.83 0.39 0.90 0.68 0.29 1.51 1.29 0.41 1.29 1.04 0.10 0.41 0.21 0.29 0.53 0.32 0.34 0.67 0.47 0.40 0.46 0.04 0.31 0.47 0.15 0.32 0.33 2.86 1.96 1.44 0.40 7.73 0.37 3.30 2.15 1.49 0.54 39.21 0.41 3.60 2.20 1.69 0.53 -14.74 0.41 3.91 2.24 1.40 0.52 3.41 0.42 4.09 2.17 1.25 0.58 6.27 Source: COMPANY FILINGS ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 35 Global Pharmaceuticals Industry Profiles Table 10: Novartis AG: key employees Name Job Title Board Chief Strategy and Growth Officer Senior Management Ana de Pro Gonzalo Director Non Executive Board Bridgette Heller Director Non Executive Board Charles L. Sawyers Director Non Executive Board Charlotte Pamer-Wieser Secretary Senior Management Daniel Hochstrasser Director Non Executive Board Aharon Gal Elizabeth (Liz) Doherty Director Non Executive Board Fiona H. Marshall President BioMedical Research Senior Management Frans van Houten Director Non Executive Board Chief Financial Officer Senior Management Harry Kirsch Joerg Reinhardt Chairman Executive Board John D. Young Director Non Executive Board Karen L. Hale Chief Legal Officer Senior Management Kees Roks Chief Audit Officer Senior Management Klaus Moosmayer Chief Ethics, Risk and Compliance Officer Senior Management Lutz Hegemann President Global Health and Sustainability Senior Management Michelle Wees Head Corporate Affairs Senior Management Michelle Weese Head Corporate Affairs Senior Management Nancy C. Andrews Director Non Executive Board Patrice Bula Director Non Executive Board Patrick Horber President International Senior Management Rob Kowalski Chief People & Organization Officer Senior Management Shreeram Aradhye Chief Medical Officer Senior Management Shreeram Aradhye President Development Senior Management Vice Chairman Executive Board President Operations Senior Management Director Non Executive Board Chief Executive Officer Senior Management Simon Moroney Steffen Lang Ton Buechner Vasant Narasimhan Source: COMPANY FILINGS ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 36 Global Pharmaceuticals Industry Profiles Table 11: Novartis AG: key employees Continued Name Victor Bulto Job Title Board President Innovative Medicines US Senior Management Director Non Executive Board William T. Winters Source: COMPANY FILINGS ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 37 Global Pharmaceuticals Industry Profiles 8.3. Pfizer Inc. 8.3.1. Company Overview Pfizer Inc. (Pfizer or 'the company') is a research-based global biopharmaceutical company. It develops consumer healthcare products, vaccines, medicines, and therapies to treat various heath conditions including inflammation and immunology, neuroscience and pain, cardiovascular and metabolic, oncology and rare disease. The company sells its consumer healthcare products through pharmacies, distributors, and convenience stores. It also sells prescription medicines through retailers, wholesalers, hospitals, pharmacies and government agencies. Pfizer has business operations in Americas, Europe, Asia-Pacific, the Middle East and Africa. The company is headquartered in New York, the US. The company reported revenues of (US Dollars) US$100,330 million for the fiscal year ended December 2022 (FY2022), an increase of 23.4% over FY2021. In FY2022, the company’s operating margin was 36.1%, compared to an operating margin of 28.9% in FY2021. In FY2022, the company recorded a net margin of 31.3%, compared to a net margin of 27% in FY2021. 8.3.2. Key Facts Table 12: Pfizer Inc.: key facts Head office: 66 Hudson Boulevard East New York, New York, United States Number of Employees: 83000 Website: www.pfizer.com Financial year-end: December Ticker: PFE Stock exchange: New York Stock Exchange Source: COMPANY WEBSITE 8.3.3. © GlobalData Business Description Pfizer Inc. (Pfizer or 'the company'), a global bio-pharmaceutical company, is involved in the discovery, development, and manufacture of healthcare products. The company operates in more than 185 countries across Europe, Asia, the Americas, the Middle East and Africa. The company conducts its business through two reportable segments: Biopharma and Pfizer CentreOne (PC1). Under the Biopharma it includes six business units – Oncology, Inflammation & Immunology, Rare Disease, Hospital, Vaccines and Internal Medicine. Its major products include Prevnar 13/Prevenar 13, Ibrance, Eliquis, Xeljanz, Enbrel (outside the U.S. and Canada), Chantix/Champix, Sutent , Xtandi , Vyndaqel/Vyndamax. In FY2022, the Pfizer Biopharmaceuticals Group segment reported revenue of US$98,988.0 million, which accounted for 98.7% of the company’s total revenue. Under PC1 the company offers contract development and manufacturing organization and supplies specialty active pharmaceutical ingredients. In FY2022, the PC1 segment reported revenue of US$1,342.0 million, which accounted for 1.3% of the company's total revenue. Geographically, the company classifies its operations into two segments: the US and International. In FY2022, the US accounted for 42.3% of the company’s revenue, followed by Developed market 21.9%, Emerging Markets 20%. ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 38 Global Pharmaceuticals Industry Profiles Table 13: Pfizer Inc.: annual financial ratios Key Ratios Growth Ratios Sales Growth % Operating Income Growth % EBITDA Growth % Net Income Growth % EPS Growth % Working Capital Growth % Equity Ratios EPS (Earnings per Share) USD Dividend per Share USD Dividend Cover Absolute Book Value per Share USD Profitability Ratios Gross Margin % Operating Margin % Net Profit Margin % Profit Markup % PBT Margin (Profit Before Tax) % Return on Equity % Return on Capital Employed % Return on Assets % Return on Working Capital % Operating Costs (% of Sales) % Administration Costs (% of Sales) % Liquidity Ratios Current Ratio Absolute Quick Ratio Absolute Cash Ratio Absolute Leverage Ratios Debt to Equity Ratio Absolute Net Debt to Equity Absolute Debt to Capital Ratio Absolute Efficiency Ratios Asset Turnover Absolute Fixed Asset Turnover Absolute Inventory Turnover Absolute Current Asset Turnover Absolute Capital Employed Turnover Absolute Working Capital Turnover Absolute 2018 2019 2020 2021 2022 -22.31 -68.73 -45.76 -47.67 -54.74 68.64 0.85 203.57 75.58 45.92 17.12 -124.91 1.16 -38.90 -32.88 -43.72 18.34 -303.22 95.16 211.73 132.94 139.98 252.05 86.09 23.43 54.29 44.02 42.73 22.76 -46.42 1.05 1.36 0.77 11.09 1.23 1.44 0.85 11.41 1.45 1.52 0.96 11.36 5.12 1.56 3.28 13.74 6.28 1.60 3.93 17.03 78.27 9.95 27.32 360.16 8.80 17.59 3.18 6.73 22.48 90.05 30.42 80.46 29.95 39.52 411.90 27.90 25.77 9.46 9.95 -273.96 70.05 30.32 79.82 18.09 21.99 395.55 16.89 14.48 5.87 5.69 82.37 81.91 27.38 62.25 28.89 27.04 164.90 29.91 28.47 16.92 13.09 137.97 71.11 14.90 66.02 36.12 31.27 194.25 34.61 32.80 23.37 16.57 397.29 63.88 13.01 1.57 1.33 0.04 0.88 0.69 0.03 1.35 1.04 0.07 1.40 1.19 0.05 1.22 1.00 0.01 0.66 0.36 0.40 0.83 0.67 0.45 0.63 0.44 0.39 0.50 0.10 0.33 0.37 0.14 0.27 0.25 3.00 1.18 0.90 0.32 2.26 0.25 2.98 1.10 1.00 0.32 -9.15 0.26 2.82 1.11 1.23 0.32 4.55 0.48 4.92 3.59 1.72 0.59 4.78 0.53 5.42 3.78 1.81 0.65 11.00 Source: COMPANY FILINGS ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 39 Global Pharmaceuticals Industry Profiles Table 14: Pfizer Inc.: key employees Name Job Title Board Aamir Malik Chief Business Innovation Officer Senior Management Aamir Malik Executive Vice President Senior Management Albert Bourla Chairman Executive Board Albert Bourla Chief Executive Officer Executive Board Chris Boshoff Chief Oncology Research and Development Officer Senior Management Chris Boshoff Executive Vice President Senior Management Dan R. Littman Director Non Executive Board David M. Denton Chief Financial Officer Senior Management David M. Denton Executive Vice President Senior Management Douglas M. Lankler Executive Vice President Senior Management General Counsel Senior Management Douglas M. Lankler Francesca DeMartino Chief Investor Relations Officer Senior Management Helen H. Hobbs Director Non Executive Board James C. Smith Director Non Executive Board James Quincey Director Non Executive Board Joseph J. Echevarria Director Non Executive Board Meenakshi Nevatia Director Executive Board Meenakshi Nevatia Managing Director Executive Board Mikael Dolsten Chief Scientific Officer Senior Management Mikael Dolsten President Worldwide Research, Development and Medical Senior Management Mike McDermott Chief Global Supply Officer Senior Management Mike McDermott Executive Vice President Senior Management Payal Sahni Becher Chief People Experience Officer Senior Management Payal Sahni Becher Executive Vice President Senior Management Ronald E. Blaylock Director Non Executive Board Sally Susman Chief Corporate Affairs Officer Senior Management Sally Susman Executive Vice President Senior Management Scott Gottlieb Director Non Executive Board Source: COMPANY FILINGS ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 40 Global Pharmaceuticals Industry Profiles Table 15: Pfizer Inc.: key employees Continued Name Job Title Board Shantanu Narayen Director Non Executive Board Susan Desmond-Hellmann Director Non Executive Board Susan Hockfield Director Non Executive Board Suzanne Nora Johnson Director Non Executive Board Source: COMPANY FILINGS ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 41 Global Pharmaceuticals Industry Profiles 8.4. Johnson & Johnson 8.4.1. Company Overview Johnson & Johnson (J&J or 'the company') is a health care company that develops, manufactures, and markets consumer health care products, pharmaceuticals, and medical devices. It offers pharmaceuticals in the therapeutic areas of immunology, oncology, neuroscience, infectious diseases and vaccines, pulmonary hypertension, cardiovascular and metabolism. Its medical devices include general surgery, biosurgical, endomechanical and energy products; electrophysiology products, vision products and phthalmic products. The company buy raw material from multiple sources. The company markets its products under Simponi, Remicade, Stelara, Aveeno, Clean & Clear, Johnson's Adult, Dabao, Le Petite Marseillais, Neutrogena and Ogx brand names. J&J distributes its pharmaceutical products, medical devices and consumer products to retailers, wholesalers, health care professionals and hospitals and through a network of retail outlets and distributors. It has business presence across the Americas, Europe, Asia-Pacific and Africa. The company is headquartered in New Brunswick, New Jersey, the US. The company reported revenues of (US Dollars) US$94,943 million for the fiscal year ended January 2022 (FY2022), an increase of 1.2% over FY2021. In FY2022, the company’s operating margin was 22.9%, compared to an operating margin of 24.3% in FY2021. In FY2022, the company recorded a net margin of 18.9%, compared to a net margin of 22.3% in FY2021. The company reported revenues of US$21,351 million for the third quarter ended October 2023, a decrease of 49.7% over the previous quarter. 8.4.2. Key Facts Table 16: Johnson & Johnson: key facts Head office: One Johnson & Johnson Plaza , New Brunswick, New Jersey, United States Telephone: 17325242455 Fax: 17322140332 Number of Employees: 152700 Website: www.jnj.com Financial year-end: January Ticker: JNJ Stock exchange: New York Stock Exchange Source: COMPANY WEBSITE 8.4.3. © GlobalData Business Description Johnson & Johnson (J&J or 'the company') is a manufacturer and marketer of healthcare products. The company offers a range of medical devices, consumer healthcare and pharmaceutical products. J&J sells its products through retailers, wholesalers, hospitals and health care professionals. It has business operations in the Americas, Europe, Asia-Pacific and Africa. The company operates through three reportable business segments: Pharmaceutical, MedTech and Consumer Health. The company’s Pharmaceutical segment produces and markets products in six therapeutic areas, including immunology (rheumatoid arthritis, inflammatory bowel disease and psoriasis), infectious diseases and vaccines (HIV/ AIDS), neuroscience (neurodegenerative disorders, mood disorders and schizophrenia), oncology (prostate cancer and hematologic malignancies), pulmonary hypertension (pulmonary arterial hypertension) and cardiovascular and metabolism (thrombosis and diabetes). The segment’s major products in include Simponi, Remicade, Stelara, Simponi Aria, Edurant, Tremfya, Prezista, Intelence, Symtuza, Prezcobix/Rezolsta, Invega Trinza/Trevicta, Concerta, Risperdal Consta, Invega Sustenna/Xeplion and Zytiga. It also offers Darzalex, ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 42 Global Pharmaceuticals Industry Profiles Procrit/Eprex, Velcade, Imbruvica, Xareltoe, Opsumit, Invokana, Invokamet/Vokanamet and Uptravi. The company distributes these products directly to retailers, wholesalers, hospitals and health care professionals for prescription use. In FY2022, the Pharmaceutical segment reported revenue of US$52,563 million, which accounted for 55.4% of the company’s total revenue. J&J’s MedTech segment manufactures and markets products used by physicians, nurses, hospitals, eye care professionals and clinics. These products include orthopaedic products, general surgery, biosurgical, endomechanical and energy products; electrophysiology products for the treatment of cardiovascular disease; sterilization and disinfection products to reduce surgical infection; and vision products, including disposable contact lenses and ophthalmic products related to cataract and laser refractive surgery. The segment distributes its products to wholesalers, hospitals and retailers. In FY2022, the MedTech segment reported revenue of US$27,427 million, which accounted for 28.9% of the company’s total revenue. The company's Consumer Health segment develops, manufactures and markets products for baby care, oral care, beauty, women's health care and wound care. It also offers over-the-counter (OTC) pharmaceutical products. The company markets baby care products under Johnson's brand, Oral care products under Listerine brand, beauty products under Aveeno, Clean & Clear, Dabao, Johnson's Adult, Le Petite Marseillais, Neutrogena and Ogx brand names. It sells women's health care products under Stayfree and Carefree sanitary pads and O.B. tampon brands outside of North America. The company’s major wound Care brands include Band-Aid and Neosporin. The company's OTC pharmaceutical products include cold, flu, allergy and heartburn products, which are marketed under Tylenol, Sudafed, Benadryl, Zyrtec, Motrin IB ibuprofen and Pepcid brand names. J&J sells its consumer products to both retail outlets and distributors globally. In FY2022, the Consumer segment reported revenue of US$14,953 million, which accounted for 15.7% of the company’s total revenue. Geographically, the company classifies its business operations into four regions: US; Europe; Asia-Pacific, Africa; and Western Hemisphere excluding US. In FY2022, the United States accounted for 51.2% of the company's total revenue, followed by Europe (24.7%), Asia-Pacific, Africa (17.7%), and Western Hemisphere excluding US (6.5%). ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 43 Global Pharmaceuticals Industry Profiles Table 17: Johnson & Johnson: annual financial ratios Key Ratios Growth Ratios Sales Growth % Operating Income Growth % EBITDA Growth % Net Income Growth % EPS Growth % Working Capital Growth % Equity Ratios EPS (Earnings per Share) USD Dividend per Share USD Dividend Cover Absolute Book Value per Share USD Profitability Ratios Gross Margin % Operating Margin % Net Profit Margin % Profit Markup % PBT Margin (Profit Before Tax) % Return on Equity % Return on Capital Employed % Return on Working Capital % Operating Costs (% of Sales) % Administration Costs (% of Sales) % Liquidity Ratios Current Ratio Absolute Quick Ratio Absolute Cash Ratio Absolute Leverage Ratios Debt to Equity Ratio Absolute Net Debt to Equity Absolute Debt to Capital Ratio Absolute Efficiency Ratios Asset Turnover Absolute Fixed Asset Turnover Absolute Current Asset Turnover Absolute Capital Employed Turnover Absolute Working Capital Turnover Absolute 2018 2019 2020 2021 2022 0.59 -3.73 -2.37 -1.16 13.70 -37.11 0.64 -4.80 -2.50 -2.68 -11.24 -6.08 13.55 38.06 27.13 41.89 32.01 80.16 -14.70 -15.00 -12.72 -14.07 -12.32 -103.22 6.46 -22.20 -22.20 95.94 23.51 -100.00 7.87 3.75 2.10 22.44 6.99 3.98 1.76 22.59 9.22 4.19 2.20 24.04 8.09 4.45 1.82 28.16 9.99 4.70 2.12 29.39 66.54 21.12 18.42 198.87 21.12 25.60 14.79 121.59 78.88 27.03 65.70 19.98 17.82 191.54 19.98 25.42 14.23 186.12 80.02 26.74 68.16 24.29 22.26 214.10 24.29 23.25 12.46 188.67 75.71 26.30 69.25 24.20 22.43 225.22 24.20 28.20 16.65 144.58 75.80 25.31 68.82 17.69 41.28 220.71 17.69 23.36 14.71 -3810.83 82.31 25.26 1.47 1.20 0.19 1.26 1.01 0.15 1.21 0.99 0.12 1.35 1.12 0.11 0.99 0.77 0.18 0.50 0.17 0.33 0.47 0.14 0.32 0.56 0.16 0.36 0.46 0.03 0.31 0.52 0.21 0.34 0.53 4.60 1.80 0.67 5.51 0.50 4.30 1.71 0.67 8.81 0.53 4.73 1.67 0.62 9.44 0.43 3.92 1.38 0.69 5.95 0.91 8.15 3.08 0.61 -157.46 Source: COMPANY FILINGS ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 44 Global Pharmaceuticals Industry Profiles Table 18: Johnson & Johnson: key employees Name Job Title Board A. Eugene Washington Director Non Executive Board Anne M. Mulcahy Director Non Executive Board Ashley McEvoy Chairman Medical Devices Executive Board Ashley McEvoy Company Group Chairman, Consumer Medical Devices Senior Management Ashley McEvoy Executive Vice President Executive Board Charles Prince Director Non Executive Board D. Scott Davis Director Non Executive Board Darius Adamczyk Director Non Executive Board Elizabeth Forminard General Counsel Senior Management Eugene A. Woods Director Non Executive Board Hubert Joly Director Non Executive Board Ian E. L. Davis Director Non Executive Board James Swanson Chief Information Officer Executive Board James Swanson Director Executive Board James Swanson Executive Vice President Executive Board Director Non Executive Board Jennifer Taubert Chairman Pharmaceuticals Executive Board Jennifer Taubert Company Group Chairman, Pharmaceuticals, The Americas Senior Management Jennifer A. Doudna Jennifer Taubert Executive Vice President Executive Board Jessica Moore Vice President Investor Relations Senior Management Joaquin Duato Chairman Executive Board Joaquin Duato Chief Executive Officer Executive Board Executive Vice President Pharmaceuticals, Research and Development Senior Management Kathryn E. Wengel Chief Global Supply Chain Officer Senior Management Kathryn E. Wengel Executive Vice President Senior Management Kurt Van den Bosch Chief Financial Officer Senior Management Marillyn A. Hewson Director Non Executive Board Mark A. Weinberger Director Non Executive Board John Reed Source: COMPANY FILINGS ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 45 Global Pharmaceuticals Industry Profiles Table 19: Johnson & Johnson: key employees Continued Name Job Title Board Mark B. McClellan Director Non Executive Board Mary C. Beckerle Director Non Executive Board Michael H. Ullmann Executive Vice President Senior Management Michael H. Ullmann General Counsel Senior Management Nadja West Director Non Executive Board Paula A. Johnson Director Non Executive Board Peter M. Fasolo Chief Human Resources Officer Senior Management Peter M. Fasolo Executive Vice President Senior Management Director Non Executive Board Thibaut Mongon Chairman Consumer Health Executive Board Thibaut Mongon Ronald A. Williams Executive Vice President Executive Board Vanessa Broadhurst Director Executive Board Vanessa Broadhurst Executive Vice President Global Corporate Affairs Executive Board William N. Hait Chief External Innovation, Medical Safety and Global Public Health Officer Executive Board William N. Hait Director Executive Board William N. Hait Executive Vice President Executive Board Source: COMPANY FILINGS ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 46 Global Pharmaceuticals Industry Profiles 9. Macroeconomic Indicators 9.1. Country data Table 20: Global exchange rate, 2018–22 Year Exchange rate (€/$) 2018 1.1810 2019 1.1200 2020 1.1405 2021 1.1832 1.0538 2022 Source: GlobalData ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED © GlobalData Page | 47 Global Pharmaceuticals Industry Profiles 10. Appendix 10.1. Methodology GlobalData Industry Profiles draw on extensive primary and secondary research, all aggregated, analyzed, crosschecked and presented in a consistent and accessible style. Review of in-house databases – Created using 250,000+ industry interviews and consumer surveys and supported by analysis from industry experts using highly complex modeling & forecasting tools, GlobalData’s in-house databases provide the foundation for all related industry profiles Preparatory research – We also maintain extensive in-house databases of news, analyst commentary, company profiles and macroeconomic & demographic information, which enable our researchers to build an accurate market overview Definitions – Market definitions are standardized to allow comparison from country to country. The parameters of each definition are carefully reviewed at the start of the research process to ensure they match the requirements of both the market and our clients Extensive secondary research activities ensure we are always fully up-to-date with the latest industry events and trends GlobalData aggregates and analyzes a number of secondary information sources, including: - National/Governmental statistics - International data (official international sources) - National and International trade associations - Broker and analyst reports - Company Annual Reports - Business information libraries and databases Modeling & forecasting tools – GlobalData has developed powerful tools that allow quantitative and qualitative data to be combined with related macroeconomic and demographic drivers to create market models and forecasts, which can then be refined according to specific competitive, regulatory and demand-related factors Continuous quality control ensures that our processes and profiles remain focused, accurate and up-to-date ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 48 Global Pharmaceuticals Industry Profiles 10.2. Industry associations 10.2.1. International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) Chemin des Mines 9, 1202 Geneva, Switzerland Tel.: 41 22 338 32 00 Fax: www.ifpma.org 10.2.2. Pharmaceutical Research and Manufacturers of America 950 F Street, NW Suite 300, Washington, DC 20004 Tel.: 202 835 3400 Fax: https://phrma.org/ 10.2.3. European Federation of Pharmaceutical Industries and Associations (EFPIA) Leopold Plaza Building, Rue du Trone 108, B-1050 Brussels Tel.: 32 02 626 25 55 Fax: https://www.efpia.eu/ 10.2.4. Association for Accessible Medicines 601 New Jersey Ave NW, Suite 850 Washington DC 20001 Tel.: 202 249 7100 Fax: https://accessiblemeds.org/ 10.2.5. International Pharmaceutical Federation Andries Bickerweg 5 2517 JP The Hague Netherlands Tel.: 31 0 70 30 21 970 ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 49 Global Pharmaceuticals Industry Profiles Fax: https://www.fip.org/ 10.3. Related GlobalData research 10.3.1. Industry Profile Global Generics Pharmaceuticals in Canada Pharmaceuticals in the United States Pharmaceuticals in Europe Pharmaceuticals in Asia-Pacific ©GlobalData THIS PROFILE IS A LICENSED PRODUCT AND IS NOT TO BE PHOTOCOPIED Page | 50 Global Pharmaceuticals Industry Profiles | About GlobalData GlobalData is a leading provider of data, analytics, and insights on the world's largest industries. In an increasingly fast-moving, complex, and uncertain world, it has never been harder for organizations and decision makers to predict and navigate the future. This is why GlobalData’s mission is to help our clients to decode the future and profit from faster, more informed decisions. As a leading information services company, thousands of clients rely on GlobalData for trusted, timely, and actionable intelligence. Our solutions are designed to provide a daily edge to professionals within corporations, financial institutions, professional services, and government agencies. Unique Data We continuously update and enrich 50+ terabytes of unique data to provide an unbiased, authoritative view of the sectors, markets, and companies offering growth opportunities across the world's largest industries. Expert Analysis We leverage the collective expertise of over 2,000 in-house industry analysts, data scientists, and journalists, as well as a global community of industry professionals, to provide decision-makers with timely, actionable insight. Innovative Solutions We help you work smarter and faster by giving you access to powerful analytics and customizable workflow tools tailored to your role, alongside direct access to our expert community of analysts. One Platform We have a single taxonomy across all of our data assets and integrate our capabilities into a single platform – giving you easy access to a complete, dynamic, and comparable view of the world’s largest industries. WWW.GLOBALDATA.COM © GlobalData Plc 2023 | 51 Global Pharmaceuticals Industry Profiles Disclaimer: All Rights Reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission of the publisher, GlobalData. The facts of this report are believed to be correct at the time of publication but cannot be guaranteed. Please note that the findings, conclusions and recommendations that GlobalData delivers will be based on information gathered in good faith from both primary and secondary sources, whose accuracy we are not always in a position to guarantee. As such, GlobalData can accept no liability whatsoever for actions taken based on any information that may subsequently prove to be incorrect. WWW.GLOBALDATA.COM © GlobalData Plc 2023 | 52
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