Simple and accurate process control for research
and pilot plant bioreactors and fermentors
Applikon Biotechnology
S I M P L E A N D A C C U R AT E P R O C E S S C O N T R O L F O R R E S E A R C H A N D P I L O T P L A N T B I O R E A C T O R S A N D F E R M E N T O R S
ez-Control
The system controls pH, Temperature, Dissolved Oxygen, Foam/Level and Agitation.
The color touch screen interface easily guides the user through operation of the controller.
The adaptive control features allow the user to focus on the process while the controller keeps
tight control on the important process parameters.
The controller’s unique design make it easy to use, provides a small footprint, is flexible and
accurate thus giving it capabilities that are beyond any other laboratory process control system.
Advanced computer
interface
The computer connection uses an Ethernet interface.
This means that you can plug it into a network and collect the data from anywhere in the network using one of
Applikon’s BioXpert software or other SCADA programs,
for which an OPC server is available.
Easy communication
The integrated web server allows access to the machine using standard internet browsers. Via the browser the
machine can be operated and actual process data can be
Easy operation
The intuitive color touch screen display gives a clear
overview of all process parameters. Data is presented
viewed. Your standard software can be used to view or
control the system in the laboratory while you are at your
desk.
numerically, in line graphs and bar charts.
Expandibility
Security
The system has three user levels: Viewer, Operator and
Engineer all with their own access rights.
The optional ADDA board offers an additional 8 analog
inputs, 4 analog outputs, 8 digital inputs and 8 digital
outputs.
Using the touch screen interface the user can alter the
This additional I/O power can be used to connect
configuration of the system. This enables the system to
Biomass monitors, balances, gas analyzers, variable speed
be used for different cultures without adding or removing
pumps, fixed speed pumps valves and other
hardware. Just select the desired operation mode from the
equipment to the ez-Control.
display and start the next culture.
Virtually any bioprocess can be controlled through the
standard 5 control loops and the controlled 14 outputs.
Easy updates
With the ADDA card the total I/O count even reaches an
Software updates are easy when functional updates
impressive 21 inputs and 26 control outputs. This is in
are available. Just connect the USB key with the software
addition to the 2 integrated alarm outputs (process alarm
update to the USB port and the system will automatically
and device alarm).
load the latest firmware.
Other options include bottle racks for liquid additions
and a set of lifting brackets for transport of ez-Control.
ez-Control is an easy
to use control system
Ether net computer interface allows
Emergency stop switches
easy integration of the ez-Controller
the system to safe position
into your network
in case of emergency
Sensor conne c t i o n s f o r :
U S B c o n n e c t i on
pH and DO
Temperature a n d
T F T c o l o r t o u c h s c reen
Foam/Level
int e r f a c e fo r e a s y n a v i g a t i on
a n d c l e a r d a t a d i s p lay
Motor and
Encoder (mot o r )
Optional ADDA c a rd
for additional I / O
G a s m i x i n g a n d e a s y gas
s e l e c t i o n s y s t em
User friendly d e t a c h a b l e
and autoclava b l e b o t t l e
U p t o 4 g a s ro t a m e t e r s a nd
rack accomm o d a t e s u p
up t o 4 m a s s f l o w c o n t ro l l ers
to 3 liquid add i t i o n b o t t l e s
f o r f l e x i b l e g a s s u p ply
Pump section with up to
Temperature section for thermocirculator,
3 easy access fixed speed pumps
cooling water valve or heating blanket.Quick release
for controlled liquid addition
connections for condensor and heat exchanger
Applikon Biotechnology
Affordable
ez-Control can be ordered as part of Applikon’s
BioBundle Family, therefore making this advanced system
very affordable.
Enhanced documentation
and validation
ez-Control was developed and documented in compliance with GAMP 4 guidelines to enable users to fully
validate the system for their process.
The system is 21CFR part 11 compliant. The validation
documentation package is available as an option.
Adaptive control
Temperature
measurement
and control
What makes this controller smart is its capability
Temperature is measured using a Pt-100 sensor and
to use adaptive control technology to automatically
can be controlled using a built-in thermocirculator, a
set the PID values. This results in shorter development
times and reduced time to market for your new products.
The adaptive process control can determine the
silicone heating blanket or a cooling water valve.
pH measurement
and control
pH is measured using a standard pH probe and can
be controlled via a choice of acid pump, CO2 mass flow
optimal process conditions while the process is run-
controller, CO2 rotameter with solenoid on/off control valve
ning. This is particularly useful when viscosity of the
and an alkali pump.
culture increases during the process or when other
physical properties of the process change. The adaptive mode guarantees the best process control performance without the need to be a control specialist.
Foam/Level
measurement
and control
Foam/Level is measured through a conductivity sensor (adjustable tripping point) and is controlled using an
antifoaming agent pump or medium addition or removal
pump.
Dissolved oxygen
measurement and
control
Agitation measurement
and control
Dissolved Oxygen is measured using a standard pola-
The powerful but quiet permanent magnet dc stir-
rographic oxygen sensor. The system can accommodate
rer motor uses an incremental encoder for feedback.
up to 3 mass flow controllers for accurate gas flow control,
This guarantees accurate stirrer speed control over the
up to 3 rotameters with optional solenoid on/off control
full stirrer speed range independent of the viscosity of the
valves for gas supply to the culture.
culture.
Specification
Dimensions
H, D, W (mm)
Voltage
115/230 Vac
Power
1300 VA
IP rating
Top, left side and front side: IP54, Right side and rear: IP20 (sensor connections)
Weight
710, 400, 370
approx. 40 kg (depending on configuration)
Utility connections
Gas (air, Oxygen Nitrogen CO2)
6 mm O.D. festo quick connectors
Water in
Quick release connector with hose barb for 6 mm I.D. tubing
Water out
Quick release connector with hose barb for 6 mm I.D. tubing
Electricity
Euro connector
Utility pressure
Gas (air, Oxygen Nitrogen CO2):
2barg, Water: 2 barg
Control loops
Number
5; pH, Temperature, Dissolved Oxygen, Foam/Level and Agitation
Type
Three term PID for pH, Temperature, Dissolved Oxygen and Agitation,
on/off control for Foam/Level
Adaptive auto tuning
Selectable for pH, Temperature and Dissolved Oxygen
Measurement range
0 - 150°C
Measurement accuracy
0.1°C
pH
Measurement range
0 - 14 pH
Measurement accuracy
0.01 pH
Dissolved Oxygen
Measurement range
0 - 120% saturation (both air and pure oxygen via automatic
Temperature
dynamic range)
Measurement accuracy
0.10%
Foam/Level
Measurement range
Conductivity range: 26 or 200 µSiemens
Agitation
Measurement range
P100: 10 - 1250 rpm,
P140 10 - 2000 rpm,
P310 10 - 1250 rpm,
P1000 10 - 1000 rpm
Measurement accuracy
+/- 0.1% full scale
Alarm
2 potential free alarm contacts
Process alarm and device alarm
Communication Interfaces
Ethernet (RJ45 connector)
10 - 100 Mbps
USB
version 1, 3 connections of which one is a host
Compatible SCADA software
BioXpert Lite, BioXpert 2 and BioXpert XP
Other communication functionality
Integrated webserver for remote diagnostics and remote operation
Firmware updates via USB key
Actuators
Pumps
Number
Up to 3 built-in
Voltage
24 Vdc
Type
Fixed speed
Speed
20 rpm
Liquid flow
Depending on tubing size up to 33 ml/min
Additional software functions
Totalizer (dosed volume), timer control, Control via SCADA,
lower and upper limit setting via control loops.
S I M P L E A N D A CUCTUO
RA
CTLE APVRAO B
C EL SES C
SO
Y NSTTR E
OL
M FS O R R E S E A R C H A N D P I L O T P L A N T B I O R E A C T O R S A N D F E R M E N T O R S
ez-Control
Specification
Rotameters
Number
up to 4
Solenoid on/off valve
up to 4
Solenoid on/off valve voltage
24 Vdc
Gas flow
Up to 30 l/min
Additional software functions
Totalizer (dosed volume), timer control, Control via SCADA,
lower and upper limit setting via control loops.
Mass Flow Controllers
Number
up to 4
Voltage
24 Vdc
Communication with controller
RS 485
Flow
Up to 30 l/min
Additional software functions
Totalizer (dosed volume), Control via SCADA,
lower and upper limit setting via control loops.
Options
GAMP 4
Yes
GAMP class
2 (Firmware)
21CFR part 11
system can be used in a 21CFR part 11 compliant environment
CE
CE certified
UL
UL compliant
CSA
CSA compliant
ADDA card
8 x analog inputs (0 - 10 Vdc),
4 x analog outputs (0/4 - 20 mA or 0 - 5 Vdc or 0 - 10 Vdc),
8 x digital inputs (24 Vdc) and
8 x digital outputs (dry contact, maximum switchable 24Vdc 1A)
Bottle rack small volume
For 3 x 0.5 liter bottles
Bottle rack large volume
For 2 x 1 liter bottles and 1 x 0.5 liter bottle
Set lifting brackets
The handles attach to the side of the controller for easy lifting and moving
Applikon Biotechnology BV De Brauwweg 13, P.O. Box 149, 3100 AC Schiedam, The Netherlands.
Phone: +31 10 298 35 66. Fax: +31 10 437 96 48. E-mail: biotech@applikon.com
www.applikon.com
Applikon ez-Control - V3X0120510 - Subject to modifications - Printed by Applikon Biotechnology bv - The Netherlands May 2007
Standards