MEGLITINIDE ANALOGUE
DRUGS
DR ESHAPPA
1ST Year postgraduate resident
Department of pharmacology
BMCRI
STRUCTURES OF MEGLTINIDES
DISCOVERY OF MEGLITINIDES
• These drugs developed as insulin
secretagogues.
• Introduced in 1995 and clinically used in 2000.
• Repaglinide developed by Novo Nordisk and
approved by FDA in 1997.
• Nataglinide developed by Ajinomoto and
Novartis, approved in 2000.
MECHANISM OF ACTION
INDICATIONS