Multiple Choice Questions (MCQs):
1. What is the diameter of the DNA double helix?
A. 11 nm
B. 2 nm
C. 30 nm
D. 700 nm
2. Which structure is described as “beads on a string”?
A. DNA double helix
B. 30 nm fiber
C. Nucleosomes on DNA
D. Entire mitotic chromosome
3. At which level does DNA first interact with histone proteins?
A. 2 nm
B. 11 nm
C. 300 nm
D. 1400 nm
4. Which structure represents chromatin in its most condensed form?
A. Beads on a string
B. Chromatin looped domains
C. 30 nm fiber
D. Mitotic chromosome
5. Which level of chromatin structure is 700 nm wide?
A. 30 nm fiber
B. Extended chromatin
C. Condensed chromatin
D. Entire chromosome
Short Answer Questions:
6. Explain the significance of nucleosomes in chromatin structure.
7. Describe the structural changes that chromatin undergoes to form a mitotic
chromosome.
8. What is the role of the centromere during chromosome condensation?
9. Compare the 30 nm fiber and the 300 nm extended chromatin structure.
10.Why is DNA packaging necessary in eukaryotic cells?
Labeling Activity (Descriptive):
11.Given a diagram of chromatin condensation (like the one you uploaded), label each
level of organization, and indicate the approximate diameter at each level.
12.Arrange the following in order of increasing compaction:
● Condensed section of chromosome
● DNA double helix
● "Beads on a string"
● 30 nm fiber
● Entire mitotic chromosome
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