Lipids Lipids are naturally occurring organic compounds of animals and plants origin and are soluble in organic solvents. Lipids compounds are composed of carbon, hydrogen and oxygen but the ratio between hydrogen and oxygen is not 2:1. The main characteristics are as, i. Insoluble in water and soluble in non – polar solvents. ii. Their primary building blocks are fatty acids, glycerol and sterols. iii. They are used by the living organism for the energy. Fats and oils are the most important lipids and are obtained from animals, plants and marine sources. Animal fats like butter and ghee, vegetable oil from seeds of plants and marine oils from sea animals are in use. The differences between fat and oil is as, Fats i. Solid or semi-solid at room temperature (25°C) ii. High proportion of long chain saturated acid components. iii. High melting and boiling points iv.Extracted from animals Oils i. Liquids at room temperature (25°C) ii. High proportion of long chain unsaturated acid components iii. Low melting and boiling points iv. Extracted from plants These are classified as, i. Simple lipids are esters of fatty acids with glycerol e.g. common fats and oils. ii. Compound lipids contain radicals in addition e.g. glycerol phospholipids. iii. Derived or associated lipids are the hydrolytic products of compound lipids e.g. sterols. Physical properties of fats and oils: The physical properties are as, Dr. Waheed Mushtaq i. State: Liquid or non-crystalline solids ii. Color, smell, taste: Colorless, odorless and tasteless in pure form iii. Solubility: Insoluble in water and soluble in non-polar solvents iv. Emulsion: Form emulsion with water on agitation v. Conductivity: Poor conductors of heat and electricity Steroids and their types A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and as signaling molecules. Hundreds of steroids are found in plants, animals and fungi. Steroids are the naturally occurring lipids which consists of three six membered rings and one five membered ring called perhydrocyclopentanophenanthrene component. These three rings are fused together and have 17 – carbon atoms. The different types of steroids are cholesterol (animal sterol), ergosterol (on irradiation to U.V is changed to ergocalciferol or vitamin D2), male & female sex hormones and hormones of adrenal cortex. CH3 R CH3 A C D B Structure of Steroid Cholesterol Cholesterol is a form of lipids, just as fats are. It is a sterol (or modified steroid), a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell membranes. When chemically isolated, it is a yellowish crystalline solid. Cholesterol also serves as a precursor for the biosynthesis of steroid hormones, bile acid and vitamin D. Cholesterol is the principal sterol synthesized by all animals including beef, Dr. Waheed Mushtaq chicken, fish, poultry, organic meat and high fat dairy foods. In vertebrates, hepatic cells typically produce the greatest amounts. It is mostly absent among prokaryotes (bacteria and archaea). Cholesterol is a 27 carbon compound with a unique structure with a hydrocarbon tail, a central sterol nucleus made of four hydrocarbon rings, and a hydroxyl group. The center sterol nucleus or ring is a feature of all steroid hormones. Cholesterolemia Cholesterolemia is the presence of cholesterol in your blood. Your body needs cholesterol to form cell membranes and hormones as well as help the body process certain vitamins and fats. Your body relies on the right balance of cholesterol to perform its daily functions. Hypercholesterolemia An elevated levels of cholesterol in the blood lead hypercholesterolemia. Hypercholesterolemia is a lipid disorder in which your low-density lipoprotein (LDL), or bad cholesterol, is too high. This makes fat collect in your arteries (atherosclerosis), which puts you at a higher risk of heart attack and stroke. Hypocholesterolemia Abnormally low levels of cholesterol is termed as hypocholesterolemia. Hypocholesterolemia is defined as total cholesterol (TC) and low density cholesterol (LDC) levels below the 5(th) percentile of the general population adjusted for age, gender and race. Hypocholesterolemia may be attributed to inherited disorders or several secondary causes. Hypocholesterolemia was defined as a total cholesterol concentration of less than 150 mg/dl. The health issues linked with hypocholesterolemia are depression, cancer, and cerebral hemorrhage. Dr. Waheed Mushtaq Cholesterol testing The American Heart Association recommends testing cholesterol every 4–6 years for people aged 20 years or older. A blood sample after 12-hours of fasting is taken by a healthcare professional from an arm vein to measure a lipid profile. Lipid Profile: a) Total cholesterol b) HDL cholesterol (called good fats such as olive oil, sunflower oil) c) LDL cholesterol or VLDL (both called bad fats such as trans-fat) d) Triglycerides. Lipid profile normal or desirable levels: Total cholesterol………………..200 mg/dL or less HDL value……………………….40 mg/dL, or higher ("the higher, the better") LDL value………………………..100 mg/dL or less than Triglycerides level………………150 mg/dL or less than Importance of lipids The importance of lipids is as, i. Good source of energy ii. Insulating effect on the nervous tissue iii. Integral part of the cell protoplasm and cell membranes iv. Precursors of very important physiological compounds v. Excellent source of energy (9.1 calories per gram) vi. Fats prevent heat loss and water loss Trans-fat is a type of dietary fat. Of all the fats, trans fat is the worst for your health. Too much trans-fat in your diet increases your risk for heart disease and other health problems. Trans-fats Dr. Waheed Mushtaq are made when liquid oils are turned into solid fats, like shortening or margarine. Trans-fats are present in fried foods, commercial baked goods, processed food and margarine. Explanation of Lipid profile or lipid panel: Total cholesterol: This is the total amount of cholesterol that’s circulating in your blood. Here’s the formula for calculating it: HDL + LDL + 20% triglycerides = total cholesterol. HDL level: HDL is high-density lipoprotein. This is the “good” cholesterol that moves extra cholesterol from your bloodstream to your liver. Your liver then gets rid of it from your body. When you see HDL, think of “h” for helpful. HDLs help your arteries clear out the cholesterol your body doesn’t need. It’s the one number in your lipid panel that you want to be high. Omega-3/ Omega-6 are good fats present in fish and good for health of human heart. LDL level: LDL is low-density lipoprotein. This is the “bad” cholesterol that contributes to plaque buildup in your arteries. You need some LDLs because they carry cholesterol to your body’s cells. But having too many can cause problems. Dr. Waheed Mushtaq VLDL level: VLDL is very low-density lipoprotein. It’s another “bad” form that contributes to plaque buildup. VLDLs carry a type of fat (triglycerides) in your blood. If you have too many VLDLs, the extra fat can build up in your arteries. Triglycerides: This is a type of fat. You need some triglycerides. But high levels (hypertriglyceridemia) can put you at risk for atherosclerosis and other diseases. Non-HDL cholesterol: This is all the cholesterol in your blood that isn’t HDL. The formula for calculating this number is simple: Total cholesterol – HDL = Non-HDL cholesterol Minerals Minerals are elements or components which are present in food and are required by the body for developing and functioning properly. Minerals are inorganic substances and helps to maintain various bodily functions. Macrominerals Macrominerals are those minerals which are required in relatively large doses. Therefore, they are also called major minerals. Macrominerals include sodium, calcium, magnesium, potassium and phosphorus. These minerals are vital for the proper functioning and metabolism of the body. Our body cannot produce these minerals; hence, they need to be obtained from a food source. Calcium > phosphorus > potassium > sodium > magnesium Teeth and boned are made up of calcium phosphate Ca3(PO4)2 Microminerals Also called trace minerals, these are minerals which are required in small amounts. Therefore, they are also called minor minerals. Trace minerals include iron, copper, iodine, zinc, manganese, fluoride, cobalt, chloride, sulfur and selenium. Dr. Waheed Mushtaq Mineral Function Source Calcium: Calcium is the most abundant mineral in the human body, making up 1.5 to 2% of the total body weight. Helps blood clotting. Almonds, Carrots, Milk, Broccoli, Canned Fish, Papaya, Garlic, and Cashew Helps muscle contraction and nerve function. Essential for building strong and healthy bones. Macro Chloride Micro Cupper Maintains proper blood volume, blood pressure, and pH of our body fluids. Formation of red blood cells. Helps with the functioning Micro Iodine Micro Iron Micro Magnesium Macro of the nervous system. Promotes the normal functioning of the thyroid gland. Helps in the proper functioning of brain functions. Promotes normal growth and development of cells. Helps in transporting oxygen to all parts of the body (Hemoglobin). Produces and stores the energy for further metabolisms. Low levels of iron cause anemia Provides structure for healthy bones. Produces energy from the food molecules. Table Salt, Soy Sauce, liver Unprocessed Meat, Milk and Peanuts Crab, Lobster, Mussels, Oysters, Nuts, Wholegrains and Yeast extract Seafood, Seaweed and Iodised salt Meat, Eggs, Beans, Baked Potato, Dried Fruits, Green Leafy Vegetables, Whole and Enriched Grains Honey, Almonds, Seafood, Tuna, Chocolates, Pineapple, Pecans, Artichokes, and Green Leafy Vegetables Dr. Waheed Mushtaq Maintains proper functioning of muscle and nervous system. Manganese Helps maintain water Micro balance. Controls nerve impulse transmissions. Sodium Macro Sulfur Micro Phosphorous Macro Potassium Macro Maintains cellular osmotic pressure. Helps in maintaining blood volume and blood pressure and fluid balance in the body. Involved in protein synthesis. Protects your cells from damage. Helps in promoting the loosening and shedding of Skin. Helps the body store and use energy. Works with calcium in the formation of strong, healthy bones and teeth. Controls nerve impulses and muscle contractions. Helps in maintaining fluid balance in the body. Maintains proper functioning of muscle and nervous system. Aids in wound healing. Zinc Micro Supports the immune system. Cereals, Nuts, Oils, Vegetables and Wholegrains Table Salt, Cheese, Milk, Soy Sauce, and Unprocessed Meat Cheese, Eggs, Nuts, Turnips, Onions, Fish, Wheat Germ, Cucumbers, Corn, Cauliflower, and Broccoli Mushrooms, Meat, Cashews, Oats, Fish, Beans, Squash, Pecans, Carrots, and Almonds Spinach, Apples, Oranges, Tomatoes, Papaya, Bananas, Lemons, Celery, Mushrooms, Pecans, Raisins, Pineapple, Rice, Cucumbers, Strawberries, Figs, Brussels Sprouts, and Legumes Beef, Pork, Dark Meat, Chicken, Cashews, Almonds, Peanuts, Beans, Split Peas, and Lentil Dr. Waheed Mushtaq vegies Helps in the formation of Cobalt Micro strong bones. Controls the functioning of the sense organs in the nervous system. Important and essential process of cell division and reproduction. Vit B 12 (Cobalamine) Food deterioration Food deterioration is defined as a process that renders a product (food) unacceptable or undesirable for consumption and is the result of the biochemical activity of microbial populations that predominate in the product. When food items kept for a long time gets spoil as germs start growing on it. Spoilage is a process in which food items deteriorate to the point in which it is not edible to human. Types of deterioration in objects Physical agents: The four major factors which affect food nutrients physically are light, oxygen concentration, temperature and water activity. Chemical agents: occurs as a result of a chemical reaction between objects and their environment. Biological deterioration: occurs as a result of living organisms such as insects, bacteria, and mold. Mechanical deterioration: Unsafe transportation and supply of food. Traditional Methods 1. Freezing: In this method, food is cooled below 0 °C. Food kept in a refrigerator remains fresh for some days. Germs do not grow easily in cool places. We preserve food items, like milk fruit, vegetables and cooked food by keeping them in a refrigerator. Deep freezing: Keeping food, vegetables, meat and fish in the freezer for a long period. Dr. Waheed Mushtaq 2. Boiling By this method, we can preserve food for a short period of time by heating or boiling. Germs in milk are killed boiling. It is done by boiling milk for sometimes and then cooling it quickly. 3. Salting We can add salt to preserve pickles and fish. Salt addition cause dehydration (removal of water) which inhibits the growth of microbes. 4. Sweetening Excess sugar in food also acts as a preservative. We store food for a long time in the form of jams, jellies, and murabbas by adding sugar. Sugar remove water contents of food through osmosis. 5. Dehydration In this method, the food items are dried in sun to stop the growth of bacteria in them. Certain foods, like raw mangoes, fishes, potato chips and papads are preserved by this method. 6. Canning In this method, air is removed from food and put in airtight cans so that germs do not grow on them. Some food items are heated at a very high temperature and after that, sealed in a metallic container (metallic containers are mostly made up of tin or aluminum). Food items like vegetables, seafood, corn, dairy products etc are preserved through this method. 7. Pickling: Pickling is a process in which an anti-microbial liquid oil (mustard oil) is added into food as pickling agent. Sometime salt and spices are also added. Example vegetables, peppers, lemons and fruits (mango). Dr. Waheed Mushtaq
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