METABOLISM: Amino Acid Metabolism
Glucose
+
PEPCK
OAA
PEP
Alanine
Pyruvate
Leucine
Aspartate
a
H
O
+
Aspartate
Acetyl CoA
Citrate
OAA
I.C.
Malate
F.T.
- KG
S.C. S. CoA
Tyrosine
Valine
CH2—CH2 —COO-
COO -
NH3+
Glutamate
O
Glutamate
H
Glucose
+
NADH
CH2
NAD+
COO Glutamate
Glutamate
D.H.
CH2
O
•
LDH
•
+
Lactic Acid
•
•
AST
Schiff
Base Linkage
(Imine)
Alanine-NH 3+
A.
L.
T.
Transamination
- PLP
a
- KG
O
H O
•
CH2
H2O
CH2
C
Alpha Keto
Glutamate
CH2
•
N—CH 3
—C—
Alanine Amino Transaminase
•
COO -
- KG
O-
Pyruvate
CH2
a
CH2
+
-
C—C—O CH2
ALT
•
O
H3N—C—COO -
CH3
Alanine
•
C—COO -
NADPH (ra)
NADP+
+
COO
COO
OAA
O O
H3N—C—C—O -
•
G-6-phosphatase
G-6p
H O
+
Aspartate
Amino Transaminase
A.
S.
T.
H3N—C—COO -
CH2
NH3(ammonia)
AKG
•
H
C—COO -
H+
Asp
PLP -
O
Oxidative
Deamination
Keto Acid
CH2
ATP
NH 4+(ammonium)
•
C—COO -
H 3N—C—COO -
a
- KG
•
•
O
O
C—C
OCH3
Pyruvate
+
H3N—C—C—O CH2
CH2
C
•
•
Lactic
Acid
•
Acetyl
CoA
Glutamate
O
O-
•
•
ATP
•
•
•
ETC
•
•
•
•
Metabolism Amino Acid Metabolism
•
f)
I
¥-1