• ‘Scientists will not be silenced’: thousands protest Trump research cuts Researchers at Stand Up for Science rallies voice defiance against the policies of US President Donald Trump’s administration. o Julian Nowogrodzki o Humberto Basilio o Alexandra Witze News07 Mar 2025 • Microsoft quantum computing 'breakthrough' faces fresh challenge Analysis pokes holes in protocol that underpins Microsoft’s claim to have created the first topological qubits. o Dan Garisto News07 Mar 2025 • Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis. o Jie Yang o Yumi Yamashita-Kanemaru o Rahul Roychoudhuri ArticleOpen Access05 Mar 2025 • Daily briefing: The second X chromosome isn’t so silent after all The US National Institutes of Health is terminating swathes of diversity- and climate-related grants. Plus, the second X chromosome in female cells might explain why women tend to be more resilient to cognitive decline than men. o Jacob Smith Nature Briefing06 Mar 2025 • o Contents o Subscribe Current Issue06 Mar 2025 Advertisement News & Comment • Rock hunters, tree huggers and taxi drivers: Books in brief Andrew Robinson reviews five of the best science picks. o Andrew Robinson Book Review07 Mar 2025 • ‘I was told to toughen up’: is academia getting resilience all wrong? o Gemma Conroy Career Feature07 Mar 2025 • ‘Scientists will not be silenced’: thousands protest Trump research cuts o Julian Nowogrodzki o Humberto Basilio o Alexandra Witze News07 Mar 2025 • Microsoft quantum computing 'breakthrough' faces fresh challenge o Dan Garisto News07 Mar 2025 • AI tools are spotting errors in research papers: inside a growing movement o Elizabeth Gibney News07 Mar 2025 • Ice-hunting Moon lander runs into trouble ― leaving scientists in suspense o Alexandra Witze News07 Mar 2025 • How a PhD student’s lab size affects their chance of future academic success o Humberto Basilio News07 Mar 2025 Latest Reviews & Analysis • o Designer cannabinoids could be the key to pain relief without adverse effects Current approaches to pain relief are falling short. Chemically modifying a synthetic cannabinoid could enable scientists to capitalize on the body’s natural pain-killing pathway without evoking drug tolerance or psychoactivity. ▪ Iain R. Greig ▪ Ruth A. Ross News & Views05 Mar 2025 o It’s time to shine for LEDs made using ecofriendly quantum dots QLEDs — light-emitting diodes that rely on nanocrystals called quantum dots — are usually made with toxic heavy metals. A strategy has been developed to make QLEDs with a performance comparable to that of commercially available technologies but using a more environmentally friendly alloy of zinc, selenium, tellurium and sulfur, by improving the distribution of the tellurium atoms. Research Briefing05 Mar 2025 o How the brain decides when to stick at it, give up or try something new To survive, animals must continually decide whether to persevere with their current goal, switch to a new one or disengage altogether. Three genetically defined types of neuronal cell in a small midbrain area called the median raphe nucleus are shown to control decisions about whether to persevere, explore or disengage. Research Briefing05 Mar 2025 o Genus-wide plant pangenome could inform next-generation crop design A compilation of genomes from species in the genus Solanum could help scientists to blend the best aspects of productive staple crops and genetically diverse but under-studied indigenous crops. ▪ Nadia Kamal ▪ Manuel Spannagl News & Views05 Mar 2025 o Ancient reef-building corals had a little help from microbial friends Nitrogen-isotope analysis provides geochemical evidence that, similar to modern corals, some extinct coral groups had a symbiotic association with photosynthetic microorganisms. This ‘photosymbiosis’ might have contributed to the high productivity of ancient reefs in low-nutrient environments and puts long-term ecological research on ancient reefs into a fresh perspective. Research Briefing05 Mar 2025 • o Amazonian deforestation makes the wet season wetter, and the dry season dryer ▪ Wim Thiery News & Views05 Mar 2025 o Diversity in neuronal activity could be caused by differences in inputs Research Briefing05 Mar 2025 o Protein waste turned into antibiotics as a defence strategy of human cells ▪ Tim Clausen News & Views05 Mar 2025 o ‘Perfect potato’ designed thanks to unearthed genetic diversity Research Briefing05 Mar 2025 Latest Research articles • Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis o Siting Zhang o Hui Lin o Wei Kong Article06 Mar 2025 • Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis. o Jie Yang o Yumi Yamashita-Kanemaru o Rahul Roychoudhuri ArticleOpen Access05 Mar 2025 • Homogeneous ZnSeTeS quantum dots for efficient and stable pure-blue LEDs By suppressing compositional heterogeneities in cadmium-free quantum dots, environmentally friendly pure-blue-light-emitting diodes with enhanced efficiencies, lifetimes and spectral purity are achieved, rivalling state-of-the-art cadmium-based blue quantum-dot light-emitting diodes. o Qianqian Wu o Fan Cao o Xuyong Yang Article05 Mar 2025 • Real-time inference for binary neutron star mergers using machine learning Analysis of gravitational waves from merging binary neutron stars was accelerated using machine learning, enabling full low-latency parameter estimation and enhancing the potential for multimessenger observations. o Maximilian Dax o Stephen R. Green o Bernhard Schölkopf ArticleOpen Access05 Mar 2025 • TIR1-produced cAMP as a second messenger in transcriptional auxin signalling cAMP produced by the TIR1/AFB receptors of the main endogenous developmental plant hormone auxin acts as a true second messenger, revising the established paradigm of transcriptional auxin signalling. o Huihuang Chen o Linlin Qi o Jiří Friml ArticleOpen Access05 Mar 2025 Collections