International Journal of Psychology, 2022 Vol. 57, No. 3, 401–410, DOI: 10.1002/ijop.12825 A longitudinal examination of the relation between academic stress and anxiety symptoms among adolescents in India: The role of physiological hyperarousal and social acceptance Mackenzie Trevethan1 , Anjali T. Jain1 , Anuradha Shatiyaseelan2 , Aaron M. Luebbe1 , and Vaishali V. Raval1 1 Department of Psychology, Miami University, Oxford, Ohio, USA 2 Christ University, Bengaluru, Karnataka, India A cademic stress is a critical aspect of adolescent experience around the world, but particularly in countries with dense populations that lead to highly competitive college admissions. With a population of over one billion people, the competition for higher education in India is significantly high. Although research has shown that academic pressures are associated with anxiety in adolescents, this work is primarily cross-sectional. The current study examined academic stress and anxiety symptoms over time and assessed physiological hyperarousal as a mediator and social acceptance as a moderator of this relation in a sample of adolescents from India (N = 282, 13–18 years, 84% female). Adolescents completed measures of academic stress, physiological hyperarousal, social acceptance and anxiety symptoms at two-time points, 5 months apart. Findings demonstrate direct effects of academic stress on changes in symptoms of generalised anxiety and panic, as well as indirect effects through physiological hyperarousal. Social acceptance did not moderate the relation, although it uniquely predicted changes in panic disorder symptoms over time. The findings of this study contribute to the scientific understanding of a potential mechanism through which academic stress leads to anxiety among adolescents in India. Keywords: Academic stress; Anxiety; Physiological hyperarousal; Social acceptance. Adolescents around the world experience stress associated with their academic work, which may have negative health effects (Casuso-Holgado et al., 2019). Particularly for students in countries with dense populations and restricted higher education prospects, academic competition is exceedingly difficult (Sun et al., 2012). High school students in India and other Asian countries encounter state examinations that determine acceptance into universities and open the door for desired careers. Therefore, these exams are incredibly competitive and stressful (Verma et al., 2002). For some of these adolescents, challenging competition can lead to experiences of anxiety (Sun et al., 2012; Verma et al., 2002). While some cross-sectional research has shown that academic stress is associated with anxiety (Deb et al., 2014), assessments of stress and anxiety over time are limited. Thus, in the current study, we examined the association between academic stress and anxiety longitudinally in a sample of adolescents from India, a country with a population of over one billion people. Beyond demonstrating a cross-sectional association between academic stress and anxiety, there has been little research attention devoted to examining potential mechanisms that may explain this association or factors that may buffer the negative effects of stress on anxiety. Thus, we examined physiological hyperarousal as a potential mediator of this association, and social acceptance as a potential moderator. Such examinations have implications for informing intervention approaches for adolescent anxiety. Academic stress and anxiety in India As the second-most populous country in the world, India is home to 22% of the world’s adolescent Correspondence should be addressed to Mackenzie Trevethan, Department of Psychology, Miami University, 90 N Patterson Avenue, Oxford, OH 45056, USA. (E-mail: trevetma@miamioh.edu) Mackenzie Trevethan contributed to conception, analysis, drafting the article, revising; Anjali T. Jain contributed to analysis, drafting the article, revising; Anuradha Shatiyaseelan contributed to design, collection; Aaron M. Luebbe contributed to drafting the article, revising; Vaishali V. Raval contributed to conception, drafting the article, revising. © 2021 International Union of Psychological Science. 402 TREVETHAN ET AL. population. Adolescents in India experience highly competitive state-wide exams that determine their access to higher education (Verma et al., 2002). Academic success is important because it determines future occupational success and upward social and economic mobility. Thus, it is common for students from urban, middle-class families in India to attend after-school tutoring sessions to be more academically competitive. These high academic demands and pressures to succeed can be experienced as stressful for some adolescents. According to Lazarus and Folkman (1984), stress is experienced when external demands are appraised as exceeding beyond the individual’s capabilities. Given the salience of academic success for adolescents in India, stress experienced in academic situations is likely to have health consequences, including implications for mental health (Deb et al., 2014). In particular, anxiety may be relevant to examine given its prevalence and associations with academic stress. Anxiety is the second most common mental health condition (after depression) worldwide with current global prevalence estimates of 5–10% (Baxter et al., 2013). In India, anxiety symptoms have been found to be just as prevalent, if not more (e.g., 20% as per Deb et al., 2010), and anxiety symptoms are more common among adolescents compared to children (Deb et al., 2010). As children get older, academic demands increase, which may contribute to greater stress related to those demands, making them more prone to developing anxiety (Verma et al., 2002). Academic stress has been associated with anxiety and depression in samples from around the world (e.g., see American Psychological Association, 2018, USA; Deb et al., 2014, India; Casuso-Holgado et al., 2019, Spain). In a study of adolescents from high SES families in India, Bhasin et al. (2010) found that the extreme pressure to perform well on board exams was correlated with stress, depression and anxiety. Whether this pressure is from parents or the individual perceived pressure, the stress of performance expectations may be contributing to students’ experience of anxiety and depression. In another study, the more time these students spent on school-related activities outside of the classroom (e.g., tutoring or homework) the more likely they were to experience anxiety according to their mothers (Verma et al., 2002). While there are some studies that demonstrate an association between academic stress and anxiety, this work is primarily cross-sectional. Examining academic stress and anxiety over time can help establish the direction of effect. Furthermore, mechanisms that explain this relation and factors that may buffer the negative effects of stress on anxiety are understudied. Physiological hyperarousal as a mediator Selye’s (1978) stress response theory suggests that the experience of stress evokes bodily processes that signal an “alarm” response through multiple systems (i.e., cardiovascular, endocrine and nervous systems) that prepares the body to respond to the stressor. Consistent with this theory, research with White American samples has documented an association between perceived stress and physiological stress responses (i.e., heightened autonomic nervous system response, cortisol levels and hypothalamic–pituitary–adrenal axis activity) (Oldehinkel et al., 2011; Van Praag et al., 2004). PH, defined as the overarousal experienced by the autonomic nervous system, specifically the sympathetic branch (Anderson & Hope, 2008) captures this bodily response to stress. Although researchers have not specifically examined the relation between academic stress and PH, PH may be a promising candidate to examine as a potential mediator given its established associations with anxiety. Conceptually, it makes sense that the psychological experience of stress related to academic performance may contribute to increased arousal at a physiological level (Marker et al., 2017). Substantial research has indicated that PH is associated with anxiety and symptoms of panic in White middle-class Americans (Anderson & Hope, 2008). Although researchers have used both objective measures and self-reports of PH, in predicting the subjective state of anxiety, one’s perception of PH, rather than an objective measure of arousal, might be more relevant. The studies that have documented an association between PH and anxiety have utilised self-reports of both constructs (Anderson & Hope, 2008), assessing participants’ perceptions of their physiological and psychological states. Given the cross-sectional relation between academic stress and anxiety, along with a broader association between perceived stress and physiological responses, PH may be one potential mediator between academic stress and anxiety. Although the research supporting the potential mediating role of PH is based on studies with White, middle-class Americans, we expect these associations to hold for adolescents from urban, middle-class families in India. Social acceptance as a moderator In addition to potential mediators, there may be conditions that intensify or reduce the negative effects of academic stress on anxiety such that in some situations academic stress is more likely to contribute to anxiety than in others. According to the stress-buffering model, interpersonal resources or individual characteristics can reduce the negative effects of stress on individuals’ health (Wheaton, 1985). Social acceptance is one such resource (DeWall & Bushman, 2011). Defined as an indication from others (e.g., parents or peers) that they understand or support the individual and want to include them in their relationships or activities (DeWall & Bushman, 2011), © 2021 International Union of Psychological Science. ACADEMIC STRESS AND ANXIETY social acceptance may buffer the negative effects of academic stress on anxiety. Social acceptance may be particularly relevant for adolescents in India due to the salience of interdependence and inclusion of others in one’s self-construal (Roland, 1988). Despite processes of modernization, adolescents in urban-middle-class families in India define themselves in the context of others, and cognitions about others’ expectations guide social behaviour (Patole, 2018). Given this pattern, acceptance from others may be a critical factor in understanding the relation between academic stress and anxiety. Studies have shown that academic stress and social acceptance may interact to contribute to anxiety. For example, social acceptance and support from parents interacted with academic stress to predict anxiety among school children in Hong Kong, such that the association between academic stress and anxiety was weaker when emotional support from parents was high (Leung et al., 2010). In another study, McMahon et al. (2008) argued that social resources from a school (e.g., empathy and support from counsellors and teachers) can have buffering effects on academic stress. They found that social acceptance and belonging within the school was associated with lower academic stress and lower anxiety in a low-income racially diverse sample from the USA (McMahon et al., 2008). Furthermore, although they did not specifically assess social acceptance as a moderator, Renk and Smith (2007) showed a positive association between academic stress and anxiety, and a negative association between support from significant others and anxiety among college students in the USA. For adolescents in urban, middle-class families in India who experience high levels of academic stress due to the familial emphasis on academic achievement, social acceptance may serve a protective function. When adolescents feel accepted by their family members, peers and teachers, high academic stress may be unrelated or weakly related to anxiety (McMahon et al., 2008). However, high levels of academic stress combined with low acceptance from others may be particularly distressing for the adolescent. In such a condition, academic stress may be strongly associated with the experience of anxiety. Current study In the current study, our first aim was to examine the association between academic stress and anxiety symptoms cross-sectionally and longitudinally in a sample of adolescents from India. For a comprehensive assessment of anxiety, we included generalised anxiety, panic symptoms and symptoms of social phobia. For the prospective tests, we examined change in anxiety symptoms from time 1 to 2 to account for anxiety symptomatology at time 1. Based on the existing cross-sectional literature, © 2021 International Union of Psychological Science. 403 we expected academic stress to be associated with higher anxiety symptoms concurrently and over time. Our second aim was to examine the mediating role of PH. We expected significant direct effects of academic stress on anxiety symptoms, as well as significant indirect effects through PH. We expected PH to explain some of the variance in the association (i.e., partial mediation) given that there may be other potential mediators that we have not examined. Our third aim was to examine the buffering role of social acceptance. Based on the stress-buffering model (Wheaton, 1985), the main effect of social acceptance on anxiety symptoms was expected, along with an interaction between academic stress and social acceptance in predicting anxiety such that the association between academic stress and anxiety would be weaker under the condition of high social acceptance. METHOD Participants The participants were 282 adolescents from Bengaluru, India, the third-most populous city in India that represents the religious and regional diversity of the country (City Bengaluru, 2021). The adolescents ranged in age from 13 to 18 years (84% female; M age = 15.00, SD = 1.20). Most parents of the participants reported that they were Hindu (63.5%) and married (85.1%) and had a bachelor’s degree (45.4%). The reported monthly household incomes varied: 13.9% of the sample reported income above INR 61,000, 24.2% between INR 41,000–60,000, 37.3% between INR 21,000–40,000 and 24.6% less than INR 20,000. Household incomes were higher for most participants than the per capita income for the state where the high schools were located (monthly INR 13,321; Government of Karnataka, 2017). All procedures performed in the study that involved human participants was in accordance with the ethical standards of the Institutional Review Board at Miami University and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all the parents of the participants, and assent was obtained from all of the adolescents. Procedure The institutional review board at Miami University approved the study. A packet of information was sent home with adolescents enrolled in standards 9 through 12 at two high schools that represented demographic diversity in Bengaluru towards the beginning of the school year (August 2016). The information packets included a recruitment letter explaining that the study was about 404 TREVETHAN ET AL. adolescents’ feelings, thoughts and mood states, a consent form and a demographic questionnaire for the parents to complete. Parents who agreed to the participation of their child and themselves signed the consent form, completed the questionnaire, and enclosed the forms in the provided sealed envelope delivered to the child’s school. Their children were invited to group sessions at school. In the group sessions, the adolescents gave their assent and then completed four questionnaires. Five months later, these adolescents completed questionnaires for time 2 (93% were sustained at time 2). Families who participated were compensated with educational supplies worth INR 150 (US $2.29). Measures as if I cannot breathe when there is no reason for this). All the items are rated on a 4-point Likert scale ranging from 0 (never) to 3 (always) to assess the frequency of each item occurring in the participant’s life. Mean composite scores of each of the three subscales were calculated. The RCADS has established high convergent and discriminant validity, good internal consistency and an adequate factor structure in samples of children and adolescents in community and clinical settings (Chorpita et al., 2000; Chorpita et al., 2005). In this sample, the three subscales from the RCADS-C demonstrated good internal consistency (𝛼 = .79 and .80 for GAD, 𝛼 = .83 and .83 for social phobia and 𝛼 = .81 and .83 for panic disorder, at times 1 and 2, respectively. Across time, rates of anxiety symptoms ranged from 1.5% for GAD to 18.5% for panic disorder for adolescents. Demographics questionnaire The demographics information questionnaire asked questions about adolescent age, gender, family religion, family income, parents’ education and occupation and their marital status. Adolescent academic stress The Adolescent Stress Questionnaire (ASQ; Byrne et al., 2007) consists of 56 items and 10 subscales. Adolescent participants record the extent to which each item has caused them stress throughout the previous year. All items were rated on a 5-point scale ranging from 0 (not at all stressful) to 5 (very stressful). The present study utilised three of the subscales: school/leisure conflict (five items; e.g., “Not having enough time for fun”), school performance (seven items; e.g., “Keeping up with schoolwork”) and future uncertainty (three items; e.g., “Concern about your future”). In order to evaluate academic stress, a mean composite score of the three subscales was calculated. Adolescents completed the three subscales at both time points. The ASQ has been positively associated with anxiety and depression measures. In addition, this questionnaire has been established as having both good internal consistency and test–retest reliability (Byrne et al., 2007). In this sample, the ASQ demonstrated good internal consistency (𝛼 = .85, 𝛼 = .88 for the composite score at time 1 and 2, respectively). Adolescent anxiety Three subscales from The Revised Children’s Anxiety and Depression Scale (RCADS; Chorpita et al., 2000) were utilised to evaluate anxiety in adolescents. These included Generalised Anxiety Disorder (GAD) (six items; e.g., I worry about what is going to happen), Social Phobia (nine items; e.g., I worry what other people think of me) and Panic Disorder (nine items; e.g., I suddenly feel Adolescent social acceptance The current study used the social acceptance subscale of The Self-Worth Contingency Questionnaire (SWCQ; Burwell & Shirk, 2003). The social acceptance subscale has eight items (e.g., “If other people’s feelings about me change, my feelings of self-worth change as well”) that are rated on a scale from 1 (not at all true for me) to 5 (extremely true for me), indicating the extent to which they agree with eight items in each domain. We also used an additional item (i.e., “People’s feelings about you”) rated from 1 (not at all important) to 4 (extremely important). The items were summed, and a mean composite score was calculated. The SWCQ has established good reliability and validity, good internal consistency and an adequate factor structure in past research (Burwell & Shirk, 2003; Burwell & Shirk, 2006). In the current sample, the internal consistency of the social acceptance subscale was adequate (𝛼s = .76 and .77 for times 1 and 2, respectively). Adolescent PH The Physiological Hyperarousal subscale of the Affect and Arousal Scale (AAS; Chorpita et al., 2000) contains nine self-report items (e.g., “I have trouble breathing” and “Often I feel sick in my stomach”) in which adolescents indicate how true each item is in their lives. The PH subscale is rated using a 4-point Likert scale ranging from 0 (never true) to 3 (always true). The items were summed, and a mean composite score of the subscale was calculated. Adolescents completed the PH subscale at both time points. The full-scale AAS and the PH subscale have established good internal consistency (Chorpita et al., 2000). In this sample, the PH subscale had good internal consistency (𝛼s = .80 and .86 for times 1 and 2, respectively). © 2021 International Union of Psychological Science. ACADEMIC STRESS AND ANXIETY RESULTS Data management All primary variables of interest were approximately normally distributed (skew < 2.00|. and kurtosis < |4.00|) and had an acceptable range of values. Collinearity index <15 indicated no problems of multicollinearity, and Harmon’s one-factor test of common method bias also supported this conclusion (i.e., percent of variance explained by a common factor was only 45.02%). Overall, 9.6% of data were missing at time 1 and 10.1% were missing at time 2. Variables with the highest amounts of missingness were time 2 scores for adolescent GAD, social phobia, panic disorder symptoms. Total mean item scores for analyses were only calculated if participants completed 75% of the items. At times 1 and 2, Little’s MCAR test (χ2 (763) 835.990, p = .37) and (χ 2 (742) 858.99, p = .06), respectively, suggested data were missing in a pattern consistent with missing completely at random. For bivariate analyses, missing data were handled with the recommended multiple imputations (n = 40 imputed datasets using all primary variables and demographic variables in estimating algorithm; Graham, 2009). Bivariate correlations were derived from the “pooled” results of the combined 40 datasets. For path analyses estimated in Mplus, the full-information maximum likelihood was used. Table 1 presents intercorrelations among all study variables displayed separately by time point. Demographic variables (adolescent age, adolescent gender, parent age, parent gender and monthly income) were examined as possible covariates. Adolescent gender and grade were each associated with at least one dependent variable of interest. Primary models with and without these covariates included produced the same results. For parsimony, neither were included as covariates in the analyses presented here. Analyses for aim one: Association between academic stress and anxiety symptoms within and across time Bivariate correlations were examined among key study variables. Specifically, we examined if academic stress was positively correlated with PH, as well as if PH was positively correlated with adolescent anxiety. Within time, academic stress at times 1 and 2 was positively correlated with GAD, social phobia and panic disorder (see Table 1). There were positive correlations between academic stress and PH at times 1 and 2. In addition, there were positive correlations between PH with GAD and panic disorder, but not social phobia, at times 1 and 2. Several important bivariate relations warrant mention (see Table 1). Within both times 1 and 2, all adolescent © 2021 International Union of Psychological Science. 405 anxiety symptoms were positively correlated with one another. The strongest associations appear between the adolescent anxiety symptoms within time. When focusing on academic stress, GAD has the highest association at both time points. In addition, PH was most strongly associated with panic disorder at both time points. Analyses for aim two: Mediating role of physiological hyperarousal The mediation model was assessed using the path analyses via Mplus across time. Path analyses analysed the covariance matrices, and models were just identified so no fit indices are reported. To test the mediation model longitudinally (see Figure 1), rather than control for all-time 1 forms of psychopathology, time 2 GAD, social phobia and panic disorder symptoms were individually regressed on their time 1 counterpart. For example, time 2 GAD was regressed on time 1 GAD. Then, the unstandardized residuals of these regressions were used as endogenous variables to account for changes in symptoms for each symptom cluster (GAD, panic disorder, social phobia). These residuals were then regressed on time 1 academic stress and changes in PH. Results of the mediation model across time can be found in Figure 1. T1 academic stress significantly predicted changes in PH (path a), and changes in PH significantly predicted GAD and panic disorder symptoms, but not social anxiety (b paths). The direct relation between T1 academic stress and changes in GAD and panic disorder symptoms were statistically significant (path c); however, academic stress did not significantly predict changes in social phobia symptoms. The indirect effects were significant (as evidenced by zero not in the confidence interval) for changes in PH mediating the relation between time 1 academic stress and changes in GAD and panic disorder symptoms. However, the indirect effect was non-significant for PH mediating the relation between time 1 academic stress and changes in social phobia symptoms (see Figure 1). Analyses for aim three: Moderating role of social acceptance The moderation model was also assessed through the use of Mplus. The predictors were time 1 academic stress, time 1 social acceptance and the interaction between time 1 academic stress and time 1 social acceptance and the outcome variables were changes in GAD, panic disorder and social phobia symptoms over time. To avoid potentially problematic high multicollinearity with the interaction term, each of the predictor variables was mean-centred and interaction terms between academic stress and social acceptance were created. .51** .29** .06 .42** .31** .40** 9.40 (2.42) .15* .09 .02 .16** .19** .15* .14* .13 .03 .15* .10 .12 .87 (.33) −.08 .10 .01 .16** .09 .17** .01 .10 .05 .02 .06 −.06 9.98 (1.13) .26** .66** .04 .34** .29** .49** .61 (.57) — .13* .32** .31** .59** 4 .16* .11 .42** .20** .30** .06 3.25 (1.15) — .30** .45** .30** 5 .33** .30** .22** .58** .41** .28** 6.42 (3.80) — .69** .55** 6 .33** .29** .32** .54** .56** .32** 11.35 (5.48) — .55** 7 .28** .46** .12 .43** .38** .49** 5.81 (4.97) — 8 — .26** .12 .50** .45** .37** 9.43 (2.56) 9 — .11 .40** .32** .57** .71 (.64) 10 — .23** .32** .09 3.25 (1.07) 11 — .71** .58** 6.32 (3.92) 12 — .50** 10.95 (5.56) 13 — 6.37 (4.98) 14 Note: Displays the Pearson Correlation coefficients between the variables. AAS PH = The Physiological Hyperarousal subscale of the Affect and Arousal Scale; ASQ = Adolescent Stress Questionnaire; GAD = Generalised Anxiety Disorder; PD: Panic Disorder. RCADS = Revised Children’s Anxiety and Depression Scale; SA = Social Acceptance Subscale of Self-Worth Contingency Questionnaire; SOC = Social Phobia; *p < .05, **p < .01. — .28** .20** .40** .39** .30** — — .17** 3 1. Grade 2. Gender Time 1 3. ASQ 4. AAS PH 5. SA 6. RCADS GAD 7. RCADS SOC 8. RCADS PD Time 2 9. ASQ 10. AAS PH 11. SA 12. RCADS GAD 13. RCADS SOC 14. RCADS PD M(SD) 2 1 Measure TABLE 1 Bivariate correlations of academic stress, physiological hyperarousal, social acceptance, and anxiety variables 406 TREVETHAN ET AL. © 2021 International Union of Psychological Science. ACADEMIC STRESS AND ANXIETY 407 Figure 1. Path diagram of mediation analysis: Mediating role of changes in physiological hyperarousal. .Note: Light grey lines are non-significant paths, and bold lines are significant paths. Unstandardized path coefficients and standard errors (in parentheses) are shown before the slash, with standardised path coefficients shown after. Standardised covariances are shown. *p < .05, **p < .01. Effect size was calculated by dividing indirect effect by total effect and multiplying with 100 to derive the percentage of the total effect accounted for by the indirect effect Results revealed no significant interactions, although there were main effects that warrant mention (see Figure 2). Academic stress significantly predicted increases in GAD and panic disorder, but not changes in social phobia. Social acceptance uniquely predicted higher panic disorder symptoms over time, over and above academic stress. DISCUSSION Extending the literature that supports cross-sectional association between academic stress and anxiety, our findings demonstrated that academic stress predicted changes in generalised anxiety and panic symptoms over time. We also found that changes in PH mediated the associations between academic stress and changes in generalised anxiety and panic symptoms. However, social acceptance was not found to moderate the relations. Associations among anxiety symptoms The three types of anxiety symptoms (GAD, panic, social phobia) were highly correlated with one another within time. This may suggest that the differing anxiety measures collectively measure adolescents’ overall anxiety in urban, middle-class families in India. This finding is consistent with previous research with White American youth that demonstrated that social anxiety and generalised anxiety were district factors that loaded on a second-order latent general anxiety factor (Whitmore et al., 2014). Within time, academic stress had the strongest associations with GAD symptoms, compared to social anxiety © 2021 International Union of Psychological Science. and panic symptoms. Previous research has not examined relations of academic stress with specific types of anxiety, and thus, current findings are particularly informative regarding the types of anxiety symptoms most likely to be affected by academic stress. In addition, PH was most strongly associated with panic disorder at both time points. Previous studies with White American samples have found similar associations between PH and panic symptomology (Anderson & Hope, 2008), suggesting PH to be particularly relevant for panic symptomatology. Concurrent and longitudinal association between academic stress and anxiety As predicted, academic stress was associated with each of the anxiety symptom clusters both within and across time. The concurrent associations are consistent with previous findings from India supporting this relation (Casuso-Holgado et al., 2019; Deb et al., 2014). Extending this literature, the current findings are the first to show a longitudinal association at the bivariate level: Adolescents who reported higher academic stress at the beginning of the school year also reported higher changes in generalised anxiety, panic and social phobia symptoms 5 months later. Overall, these findings suggest that the experience of academic stress may contribute to anxiety in multiple forms (e.g., panic), and suggest that reducing academic stress may be a critical goal for psychosocial interventions for anxiety among Indian adolescents. 408 TREVETHAN ET AL. Figure 2. Examination of academic stress, social acceptance in the prediction of changes in anxiety symptom clusters over time. Note: Light grey lines are non-significant paths, and bold lines are significant paths. Unstandardized path coefficients and standard errors (in parentheses) are shown before the slash, with standardised path coefficients shown after. Standardised covariances are shown. *p < .05, **p < .01. Physiological hyperarousal as a mediator Consistent with the stress response theory (Selye, 1978) and previous research (Anderson & Hope, 2008), academic stress was associated with PH (e.g., shortness of breath, dryness, increased heart rate). Furthermore, there were direct effects of academic stress on changes in GAD and panic symptoms over time, and there were indirect effects through PH. These findings support the mediating role of PH, suggesting that PH may be an underlying mechanism that explains the relation between academic stress and symptoms of anxiety and panic among adolescents in India. It is important to highlight that although there was a concurrent and longitudinal association between academic stress and social phobia symptoms at the bivariate level, this association did not hold in the model that included generalised anxiety and panic symptoms. Thus, academic stress does not uniquely predict changes in social phobia symptoms, nor was there an indirect relationship through PH. The current findings suggest a separation between social and academic domains of functioning for adolescents in urban middle-class families in India such that stress in the academic domain seems to not be affecting social situations. Social acceptance as a predictor of anxiety symptoms Contrary to the stress-buffering model (Wheaton, 1985) and previous research (Leung et al., 2010), social acceptance did not moderate the relation between academic stress and changes in any of the anxiety symptoms (i.e., GAD, panic, social phobia). Thus, social acceptance does not buffer the negative effects of academic stress on anxiety. These findings further support the separation of academic and social domains for adolescents in India such that social acceptance does not seem to mitigate the effects of stress related to academics. Interestingly, social acceptance uniquely inversely predicted changes in panic disorder symptoms over time, over and above academic stress. This finding suggests that social acceptance has a stronger effect on panic symptomology in comparison to other anxiety symptoms. The social acceptance measure in this study assessed the extent to which others’ acceptance and approval matters to an individual, and thus, high scores on this measure do not necessarily indicate higher levels of social acceptance but instead that social acceptance matters to the respondent. In future work, it might be helpful to include a measure that assesses perceived levels of social acceptance. Limitations and future directions Our sample was recruited from urban, middle-class families residing in a metropolitan city in South India. Given the diversity with respect to religion, region, languages, cultural norms and lifestyles and social class across India, our findings cannot be considered generalizable to the entire country. We assessed all study variables based on adolescent self-report, and shared method variance may have led to an overestimation of effects. Future work may consider including other reporters to assess academic stress (i.e., parents or teachers) and objective measures of PH. Subjective reports of PH may not align with objective measures of PH (Hoehn-Saric & McLeod, 2000) because bodily sensations can be modified by perceptual distortions created by psychological aspects (e.g., attention to expectations and bodily states). Given that adolescents in many communities around the world experience academic stress, it is important to examine academic stress and anxiety in other parts of Asia, as well as densely populated regions such as Africa and the Middle East. Furthermore, there may be additional moderators and mediators in the relation between © 2021 International Union of Psychological Science. ACADEMIC STRESS AND ANXIETY academic stress and anxiety. PH was the only mediator investigated in this study and social acceptance was the only moderator investigated. Other variables that were not examined (e.g., temperament-based characteristics) may have an influence on this relation, which should be investigated in future work. Conclusion The current findings indicate that academic stress is associated with symptoms of generalised anxiety and panic concurrently and over a 5-month period in a sample of adolescents from India and that PH partially mediates this relationship. Social acceptance uniquely predicted lower panic symptoms over time. The current findings are the first to demonstrate that academic stress contributes to anxiety over time for Indian adolescents and that PH may be a mechanism that explains the effects of academic stress on anxiety. These findings contribute to theoretical frameworks of the development of anxiety symptoms and have practical implications for interventions to reduce anxiety. Specifically, both academic stress and PH may be important targets for interventions aimed at reducing anxiety among Indian adolescents. In addition, strengthening social acceptance may be a critical component of interventions aimed at reducing panic symptoms. Manuscript received March 2021 Revised manuscript accepted November 2021 First published online December 2021 REFERENCES . (2018). Stress in America: Generation Z. American Psychological Association, Stress in America™ Survey, American Psychological Association. Anderson, E., & Hope, D. A. (2008). 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