ETIOLOGY
Mutation of p53
tumor suppression
gene
PATHOPHYSIOLOGY
PREDISPOSING FACTORS
-Age (79 years) Elderly men at
higher risk
- Genetic Factors (2 sisters with
cancer)
Activation of
Immunologic
Mechanism
Release of B
lymphocytes, T
lymphocytes and
Natural Killer Cells
Once mutation occur in genes
like P53 these cells evade
immune detection and bypass
normal regulatory mechanisms
PRECIPITATING FACTORS
- (Former Tricycle Driver, Former
Construction worker) UV exposure
Death Of
Some Cancer
Cells
Immunosuppression
-Not circumcised
Loss of normal squamous cell apoptosis
Squamous cells undergo dysplasia
damaged or mutated cells survive.
Increased abnormal
keratinocytes production
abnormal cells accumulate
more rapidly than normal
Epidermis becomes thicker with
noticeable rough texture
Raised reddish, scaly
patch or plaque
Increase in size with mild
discomfort and itching
Carcinoma In Situ
(epidermis)
Cancel cells invade normal tissue
Malignant Tumor (Cancer)
Palpable mass
Invasion beyond
basement membrane
Raised, firm, scaly crusted
bump forms. Ulcerated
lesions, inflamed or tender
Cytokine
Release
↓ 𝑅𝐵𝐶
Tumor invades deeper tissue,
muscles and bones
Severe Pain
Lymphatic Vessel Affectation (Metastasis)
Tumor infiltrates
lymph nodes (groin)
↓ 𝐻𝑔𝑏
Anemia
Tumor affects distant organs
(Penis)
Decreased RBC and HGB
decreased oxygen transport
Fatigue, weakness, Paleness,
Dizziness Cold extremities
Further penetrate
corpora cavernosa and
corpus spongiosum
Impede Blood
Circulation
Erectile
Dysfunction
Tingling
sensation
Penetrates underlying tissue
Rapidly growing tumor
Not Circumcised
Accumulation of smegma
urinary tract, a tumor
impedes the flow of urine,
Ulcerations and crusted bump
forms surrounding the shaft
Dysuria, Bladder
Retention
Anuria
Incision
(Suprapubic)
Impede Blood
Circulation
bluish brown,
resembling warts or
crusty lesions
Localized
Infection
Cyanotic
Discoloration
The body inhibit angiogenesis, to cut
off blood supply to tumors
Inhibition of Circulation
on affected area
Tumor Hypoxia
Localized
Redness, Swelling,
discharges