Summative 3 Cranial Nerves Nancy Halliday, PhD David Ross Boyd Professor Department of Cell Biology Learning Objectives a. Identify the 12 cranial nerves by name, Roman numeral, and anatomical location. b. Locate the cranial nerves within the distinct regions of the brainstem. c. Describe the functions and distribution of each cranial nerve. d. Trace the path of each cranial nerve through the skull's foramina. e. Link cranial nerve lesions to their associated clinical functional deficits. f. Understand the sensory functions of neurons in ganglia related to cranial nerves. Cranial Nerves I II III IV V VII VIII X XI VI XII IX • There are 12 pairs. • Most emerge directly from the brain. • Two pairs emerge from the cerebrum (CN I, CN II) and the remaining pairs arise from the brainstem. • Cranial nerves are considered part of the peripheral nervous system (except CN I & CN II). • Each cranial nerve exits the cranial cavity through specific foramina (with which you should be familiar). • With the exception of CN X (Vagus), cranial nerves innervate structures only in the head and neck. Midbrain 10 Cranial Nerves emerge from the midbrain, pons, and medulla of the brainstem Midbrain: Oculomotor (CN III), Trochlear (CN IV) III IV Pons V VIII VII VI Pons: Trigeminal (CN V), Abducens (CN VI), Facial (CN VII), Cochlear (CN VIII) IX X Medulla XII XI Medulla: Glossopharyngeal (CN IX), Vagus (CN X), Accessory (CN XI), Hypoglossal (CN XII) Cranial Nerve Nomenclature • Cranial nerves are numbered in the order they have to be cut to take the brain out of the skull! III II IV I VI VII I II III V IV VI XII VIII V VII & VIII IX, X, XI XII XI Either use their name, or their Roman numeral. (Olfactory nerve, or CN I, etc.) X IX Things to consider Cranial nerves can be grouped (chunked) by function: I • Cranial nerves I, II and VIII are devoted to special senses and are related to higher order brain areas and functions • Cranial nerves III, IV, & VI are related to eyes and eye movements • Cranial nerves V, VII, IX, & X are related to branchial (pharyngeal) arches • Cranial nerves X, XI & XII innervate internal viscera, trapezius & sternocleidomastoid, and lastly, the tongue II VI III IV V VII VIII IX XII XI X Simple Rules About CN Functions • Most cranial nerves (7 of the 12) do only one thing! • Two cranial nerves have only two functions I II IV III – Oculomotor – Visceral Efferent (VE) to smooth muscles (ciliary muscle and sphincter pupillae), Somatic Efferent (SE) to extraocular skeletal muscles – Trigeminal – Somatic Afferent (SA) from face, SE to Muscles of Mastication (1st arch) VI V • Three cranial nerves have > two functions & all have the same functions (VII, IX, X) VII – VE (Parasympathetics) / VA – SA from the ear – Motor for branchial arches • 2nd Arch (CN VII) • 3rd Arch (CN IX) • 4th and 6th Arches (CN X) – Taste anterior 2/3 of tongue (CN VII) – Taste posterior 1/3 of tongue (CN IX) – Taste around the epiglottis (CN X) VIII IX XII XI X What are Pharyngeal Arches? • The pharyngeal arches, also known as visceral arches, are structures seen in the early embryo that are precursors for many structures in the head & neck. • They are recognizable in the 4th week of development. • Each arch has its own artery (aortic arches), a nerve that controls a distinct muscle group, and skeletal elements. • You will have a separate session on the pharyngeal arches next week. 4-week-old human embryo Each Branchial (Pharyngeal) Arch has its Own Cranial Nerve 1. Arch I maxillary and mandibular divisions of trigeminal nerve (V2, V3) Trigeminal Ophthalmic div Trigeminal Ganglion V 2. Arch II facial nerve (VII) VII IX X Trigeminal Maxillary div I 3. Arch III glossopharyngeal nerve (IX) I II III IV VI Trigeminal Mandibular div 4. Arches IV and VI superior and recurrent laryngeal branches of vagus nerve (X) Vagus Facial Glossopharyngeal The Details • The remaining slides introduce each of the cranial nerves in order. – Anatomical location – Specific Functions – Deficits associated with lesions of the cranial nerves Olfactory Nerve(s) – CN I Olfactory Tract Cribriform Plate Olfactory Bulb Olfactory Nerves Cribriform Plate Olfactory Epithelium Function is sense of smell (olfaction) Lesion of the Olfactory Nerves • Anosmia • Food tastes funny (loss of smell changes taste perception) • Nose is running (CSF leaking if due to trauma) Optic Nerve CN II Eye Ball Optic N. Enters orbit via optic canal Optic Chiasm Function: Vision CN II actually develops as an extension of the brain rather than a true “nerve” – explains why it is surrounded by dura. It is considered part of the CNS rather than the PNS. Optic Tract Lateral Geniculate Ganglion Optic Radiation Occipital Cortex Nasal Visual Field Temporal Visual Field Temporal Visual Field Problems with CN II (Deficit is based on the location of the lesion) Right Eye Left Eye Nasal Retinal Field Temporal Retinal Projection Nasal Retinal Projections Nerve Optic Nerve Lesion Temporal Retinal Field Tract Lateral Geniculate Ganglia Optic Chiasm Lesion Optic Tract Lesion CN III, CN IV, and CN VI Oculomotor Nerve (CN III) Trochlear Nerve (CN IV) Abducens Nerve (CN VI) Function: Extraocular (eye) movements Enter orbit via superior orbital fissure Oculomotor, Trochlear, Abducens LR6 – SO4 All the rest are 3 & Parasympathetics for the Sphincter Pupillae & Ciliary Muscle Superior Oblique Ciliary Ganglion CNIV Midbrain CNIII Pons CNVI Lateral Rectus CN III, IV, VI in the Brainstem Cross Section of Brainstem Visceral Oculomotor Nucleus Ciliary Ganglion Ciliary Muscle & Sphincter Pupillae CN III Cranial Nerve III Contains Parasympathetic Fibers (VE) that Control Lens Shape (for focus) and Pupillary Constriction in the Iris. Lesions of CN III, IV and VI • There may be diplopia with certain eye movements • Patients may say they are dizzy • If the patient’s eye cannot track medially and the pupil is dilated, think CN III (oculomotor) • If the patient’s eye cannot track laterally, think CN VI (abducens) Right Eye Left Eye Normal Trigeminal Nerve, Sensory Component Portio Major Trigeminal Ganglion (Location of Sensory cell bodies) V1 CNV V2 V3 Note that the tip of the nose is V1 – the ophthalmic division Trigeminal Nerve, Motor Component Portio Minor CN V Motor Root With Mandibular N. Mnemonic: MMATT Muscles of Mastication, Mylohyoid, Anterior belly of digastric, Tensor tympani, Tensor veli palatini Trigeminal Nerve in the Brain Stem (sensory) Divisions exit the skull via: V1 Superior Orbital Fissure V2 Foramen Rotundum V3 Foramen Ovale (sensory) Problems with the Trigeminal • Loss of muscle tone on the side of the lesion • Wasting of the Muscles of Mastication • When asked to open the jaw, the mandible deviates to the side of the lesion • Anesthesia over parts of the head – distribution depends on part of the nerve that is interrupted • Trigeminal Neuralgia (Tic de le Rue) Facial Nerve Motor Branches: To – Temporal Zanzibar – Zygomatic By – Buccal Motor – Mandibular Car - Cervical CN VII Stylomastoid Foramen Most Complex Cranial Nerve! Cranial Nerve VII Parasympathetic Secretions & Taste Functions • Facial Nerve (CN VII) Functions: • Motor root: – All Muscles of facial expression – Stylohyoid – Posterior belly of digastric – Stapedius Greater petrosal Geniculate ganglion Pterygopalatine ganglia Stapedius • Parasympathetics to: – Lacrimal gland, palate glands, and nasal mucosa (via greater petrosal n & pterygopalatine ganglion) – Submandibular and sublingual glands (via chorda tympani & submandibular ganglion) Motor root of VII • Sensory (Geniculate Ganglion) – Taste anterior 2/3’s tongue – Somatic afferents from the ear Posterior digastric Chorda tympani Stylohyoid Facial Nerve Nuclei Enters temporal bone: internal auditory meatus (parasympathetic motor) Exits skull: stylomastoid foramen (somatic motor) (sensory) Lesions of CN VII • Symptoms depend on the location of the lesion • Facial nerve palsy with decreased hearing is really bad! • Facial nerve palsy with increase in sound – not as bad! • Biggest Parasympathetic Nerve to the head • Loss of taste to anterior 2/3rd of tongue • Preservation of upper part of facial muscles – think CNS! Vestibulocochlear Nerve Functions: Hearing & Balance CN VIII Vestibular Portion Vestibule Enters skull: internal auditory meatus Saccule Ampulla of Semicircular Canal Cochlea Cochlear Portion Problems with CN VIII • Vertigo – sensation of movement or spinning and loss of balance • Menier’s disease – disorder of the inner ear that can lead to dizzy spells (vertigo) and hearing loss. • Saccades – rapid movement of the eye between fixation points • Nystagmus – eyes make repetitive, uncontrolled movements • Strabismis – Eyes are not aligned properly and point in different directions Glossopharyngeal Nerve – CN IX CN IX Sensory Functions: Carotid Body/Sinus Endodermal portion of tongue (posterior 1/3), palate, pharynx Gag Reflex Motor Functions: Stylopharyngeus M. (3rd Branchial Arch) Glossopharyngeal VE (Parasympathetic Functions) O-P Exits skull: jugular foramen NOT MUCH!! Problems with CN IX • Loss of gag reflex (loss of sensation on posterior tongue and pharynx) • Glossopharyngeal neuralgia (sharp, stabbing pulses of pain in the back of the throat and tongue, the tonsils, and the middle ear) Vagus Nerve – CN X Parasympathetic to the thorax & foregut/midgut organs Visceral Afferents from Carotid artery, thorax, and foregut/midgut structures CN X Motor Nerves of Pharyngeal Arches 4th (Superior Laryngeal N.) 6th (Recurrent Laryngeal N.) Exits skull: jugular foramen Example Problem with CN X Side of Lesion • Uvula and palate do not elevate on the side of the lesion • Uvula will deviate away from the lesion X Relaxed Only unaffected muscle contracts – so uvula points away from the side of the lesion Accessory Nerve – CN XI Exits skull: jugular foramen Lesion of CN XI • Loss of shoulder shrug • Drooping of the shoulder Hypoglossal Nerve – CN XII Exits skull: hypoglossal canal Lesions of the CN XII • Tongue points toward the side of the lesion Normal Lesion The Charts in the Remaining Slides are Study Resources. Superior orbital fissure Superior orbital fissure Somatic (general) sensory Somatic (general) sensory Trigeminal ganglion Superior orbital fissure Trigeminal ganglion Foramen ovale (Chorda tympani gets to infratemporal fossa to reach submandibular & sublingual glands via petrotympanic fissure) (Innervation to lacrimal gland, nose, palate is via greater petrosal nerve) Via lesser petrosal nerve Anterior Cervical Triangle & Deep Neck Mary Moon, Ph.D. Assistant Professor Department of Cell Biology Session Objectives a. Identify the boundaries and muscles of the anterior triangle of the neck. b. Recall the contents of the various sub-triangles in the anterior neck. c. Observe the major divisions of the cervical fascia and list the major structures contained in each. d. Describe which cervical fasciae contribute to the carotid sheath. e. Identify the innervation of the muscles of the anterior triangle of the neck. f. Trace the vascular supply within the anterior triangle of the neck. g. Describe the sensory nerves in the anterior triangle of the neck. h. Identify the large vascular structures, nerves and lymphatic vessels in the deep neck and root of the neck. i. Identify the visceral organs in the neck (trachea, larynx, thyroid gland, etc. • Orientation to the Neck Lecture Outline – Review of Cervical Fascia – Boundaries & Subtriangles • Skeletal & Cartilaginous Elements • Muscles of the Anterior Triangle – Muscular Triangle – Submandibular Triangle • Carotid Triangle – Branches of the External Carotid Artery • Veins & Lymphatics • Nerves of the Deep Neck • Viscera in Anterior Neck – Thyroid & Parathyroid – Trachea – Esophagus • Root of Neck – Great Vessel Review – Thyrocervical trunk Orientation to the Neck • Serves as a major conduit for structures passing between head and trunk/limbs • C-Spine have characteristics that lend themselves to motility, i.e. muscle attachments and flattened articular facets. • Allows positioning of the head to maximize efficiency of sensory organs • Cervical vertebrae are continuous with the Neurocranium • Viscerocranium is continuous with viscera in anterior triangle of the neck • The attachment of the head to the C-Spine makes this region vulnerable to acceleration and deceleration injury acceleration/deceleration injury Deep Cervical Fascia Pretracheal Fascia Platysma Larynx Anterior Triangle Carotid Sheath S C M * Retropharyngeal Space Danger Space Buccopharyngeal fascia Investing layer of Deep Cervical Fascia Common carotid Internal Jugular Vein Vagus Nerve Prevertebral Muscles Vertebral Body Deep Lymph Nodes Posterior Triangle Back muscles Alar fascia* Prevertebral Fascia Deep Cervical Fascia Occipital Bone Mid-sagittal view Boundaries of the Anterior Cervical Triangle • Anterior Border of SCM • Inferior Border of the Mandible • Midline of the Neck Hyoid Clavicle Subdivisions of the Anterior Triangle For Descriptive Purposes… Submandibular Triangle Carotid Triangle Submental Triangle Sternocleidomastoid Muscular Triangle Lecture Outline • Orientation to the Neck – Review of Cervical Fascia – Boundaries & Subtriangles • • Skeletal & Cartilaginous Elements Muscles of the Anterior Triangle – Muscular Triangle – Submandibular Triangle • Carotid Triangle – Branches of the External Carotid Artery • Veins & Lymphatics • Nerves of the Deep Neck • Viscera in Anterior Neck – Thyroid & Parathyroid – Trachea – Esophagus • Root of Neck – Great Vessel Review – Thyrocervical trunk Mandible Submandibular Fossa For the submandibular gland Mylohyoid Line Attachment point of mylohyoid m Digastric Fossa Attachment point of Ant. Belly of Digastric m Hyoid Bone Greater Horn Lesser Horn Anterior Lateral View Posterior Body Fracture of they Hyoid may occur with compression of the throat which leads to inability to: • Elevate the hyoid bone • Move it anterior under the tongue • Maintain separation between alimentary and respiratory tracts Skeletal & Cartilaginous Elements Hyoid bone Thyrohyoid Membrane Thyroid Cartilage: Lamina Laryngeal prominence Trachea Emergency Cricothyrotomy More Skeletal Elements Greater Horn Lesser Horn Hyoid Thyrohyoid Membrane Thyroid Cartilage Cricothyroid Ligament Cricoid Cartilage First Tracheal Ring Lecture Outline • Orientation to the Neck – Review of Cervical Fascia – Boundaries & Subtriangles • • Skeletal & Cartilaginous Elements Muscles of the Anterior Triangle – Muscular Triangle – Submandibular Triangle • Carotid Triangle – Branches of the External Carotid Artery • Veins & Lymphatics • Nerves of the Deep Neck • Viscera in Anterior Neck – Thyroid & Parathyroid – Trachea – Esophagus • Root of Neck – Great Vessel Review – Thyrocervical trunk Muscle of Facial Expression in the Anterior Triangle of the Neck Platysma CN VII Image from: Ascher et. Al. (2010). See notes for full citation Muscles of the Anterior Triangle Thyroid Cartilage Sternothyroid Sternohyoid Infrahyoid Muscles Thyrohyoid Suprahyoid Muscles Stylohyoid Mylohyoid Mylohyoid Raphe Digastric: ant. belly post. belly Omohyoid: sup. belly inf. belly Lateral View Mylohyoid 1. 4. Stylohyoid 3. Posterior Belly of Digastric Anterior Belly of Digastric 2. 9. Thyrohyoid Sternohyoid 5. Superior belly 6. omohyoid Sternothyroid 8. 7. Inferior belly omohyoid Infrahyoid Muscles (Muscular Triangle) Omohyoid (inferior & superior bellies) Attachments: 1. Sup. Border of scapula (medial to suprascapular notch) 2. Intermediate tendon 3. Body of hyoid bone Nerve: Ansa cervicalis (C1-C3) Function: Depresses & fixes hyoid. Sternohyoid Attachments: 1. Post. Sternoclavicular joint & manubrium 2. Body of hyoid bone Nerve: Ansa cervicalis (C1-C3) Function: Depresses hyoid bone after swallowing. Infrahyoid Muscles (Muscular Triangle) Thyrohyoid Attachments: 1. Thyroid cartilage (Lamina) 2. Hyoid bone Nerve: Nerve to thyrohyoid (C1 running with hypoglossal n) Function: Depresses hyoid. When hyoid is fixed raises the larynx. Sternothyroid Attachments: 1. Posterior surface manubrium 2. Thyroid cartilage Nerve: Ansa cervicalis Function: Draws larynx down. Cricothyroid Muscle Attachments: 1. Anterolateral part of cricoid cartilage 2. Inferior margin & inferior horn of thyroid cartilage Nerve: External laryngeal branch from Vagus Function: Stretches & tenses vocal ligament Anterior MOTOR Cervical Plexus (C1-C4) Posterior Sensory Geniohyoid (C1 via hypoglossal) Thyrohyoid (C1 via hypoglossal) Superior belly Omohyoid Sternothyroid Sternohyoid Inferior belly Omohyoid Loop is called ansa cervicalis (C1-C3) Submandibular Triangle/ Digastric Triangle Mandible Digastric M. Boundaries Anterior: anterior belly of digastric Posterior: posterior belly of digastric Superiorly: Mandible Floor: Mylohyoid Suprahyoid Muscles - Digastric Anterior Belly Attachments: 1. Digastric Fossa of Mandible 2. Tendon to hyoid bone Nerve: CN V3 (Off of Inferior alveolar nerve) Function: raises hyoid bone, opens mouth. Posterior Belly Attachments: 1. Mastoid process (temporal bone) 2. Tendon to hyoid bone Nerve: CN VII Function: pulls hyoid posterosuperiorly. Suprahyoid Muscles Stylohyoid Attachments: 1. Styloid process 2. Lateral hyoid bone Nerve: CN VII Mylohyoid Attachments: 1. Mylohyoid line of mandible 2. Body of hyoid bone 3. Mylohyoid raphe Function: pulls hyoid bone posterosuperiorly. Nerve: Nerve to mylohyoid (from inferior alveolar of CN V3) Function: Support the floor of the mouth, elevate the floor and hyoid bone. Suprahyoid Muscles are Innervated by Cranial Nerves Nerve to Mylohyoid (Branch of Inferior Alveolar from CN V3) Mylohyoid AD PD Facial Nerve (CN VII) AD = Ant. Digastric PD = Post. Digastric Contents of Submandibular Triangle Facial A & V Stylohyoid M Hypoglossal N Submandibular Gland Lymph Nodes (not pictured) Lecture Outline • Orientation to the Neck – Review of Cervical Fascia – Boundaries & Subtriangles • • Skeletal & Cartilaginous Elements Muscles of the Anterior Triangle – Muscular Triangle – Submandibular Triangle • Carotid Triangle – Branches of the External Carotid Artery • Veins & Lymphatics • Nerves of the Deep Neck • Viscera in Anterior Neck – Thyroid & Parathyroid – Trachea – Esophagus • Root of Neck – Great Vessel Review – Thyrocervical trunk The Carotid Triangle – Contents Tendon of Digastric m. Vagus n. Internal carotid a. Carotid a. Bifurcation Transverse cervical n Hypoglossal n. Thyrohyoid Branch (C1) External carotid a.(branches) Common carotid a. Ansa cervicalis n. Omohyoid m. Carotid Triangle & The Carotid Arterial System Superficial Temporal A Maxillary A Posterior Auricular A Occipital A *Ascending Pharyngeal A Lingual A Facial A External Carotid A Superior Thyroid A Internal Carotid A with branch Superior Laryngeal A SALFORMS External Carotid - Anterior Branches Superficial Temporal A Maxillary A Ascending Pharyngeal A Facial A Lingual A Superior Thyroid A with superior laryngeal branch Posterior Branches & Carotid Sinus Posterior Auricular A CN IX Occipital A Carotid Sinus (Sinus has receptors that sense blood pressure) (Carotid Body senses oxygen content) Body Sinus Carotid Endarterectomy Carotid occlusion can be relieved by opening the artery at its origin and removing plaque. This procedure is known as the carotid endarterectomy. Bruits(murmur) in the carotids are a good indication of carotid artery stenosis. Lecture Outline • Orientation to the Neck – Review of Cervical Fascia – Boundaries & Subtriangles • • Skeletal & Cartilaginous Elements Muscles of the Anterior Triangle – Muscular Triangle – Submandibular Triangle • Carotid Triangle – Branches of the External Carotid Artery • Veins & Lymphatics • Nerves of the Deep Neck • Viscera in Anterior Neck – Thyroid & Parathyroid – Trachea – Esophagus • Root of Neck – Great Vessel Review – Thyrocervical trunk Major Veins of the Neck R External Jugular R Internal Jugular R Subclavian vein L Internal Jugular Anterior Jugular L Subclavian vein Right versus Left Internal Jugular Vein (IJV) IJV may be accessed for diagnostic or therapeutic purposes. (SCM) Can be found between the sternal and clavicular head of the SCM The right IJV is preferable because it is usually larger and straighter. Superficial Lymphatics Lymphatics of the Deep Neck Lecture Outline • Orientation to the Neck – Review of Cervical Fascia – Boundaries & Subtriangles • Skeletal & Cartilaginous Elements • Muscles of the Anterior Triangle – Muscular Triangle – Submandibular Triangle • Carotid Triangle – Branches of the External Carotid Artery • Veins & Lymphatics • Nerves of the Deep Neck • Viscera in Anterior Neck – Thyroid & Parathyroid – Trachea – Esophagus • Root of Neck – Great Vessel Review – Thyrocervical trunk Nerves of the Deep Neck External Br. of Superior Laryngeal N. Middle Cervical Ganglion Vagus N (CN X) Phrenic N (C3-5) Sympathetic Chain Left recurrent laryngeal N Inferior cervical ganglion Sympathetic Chain (Trunks) – Bilateral structure located anterior lateral to the vertebral column – No white rami – Preganglionic cell bodies - IML of the upper thoracic spinal cord. – 3 Primary Cervical Sympathetic Ganglia • Superior, Middle, Inferior Sympathetic Trunks- Cervical Sympathetic Ganglia Superior cervical ganglia -to head and neck Middle cervical ganglia -to neck and upper limb Inferior cervical ganglia -to upper limb Receive presynaptic fibers from the superior thoracic spinal levels Contain postganglionic cell bodies Ansa Subclavia Postganglionic cell fibers will leave the chain via gray rami to pass to cervical spinal nerves Sympathetic trunk and Prevertebral Muscles Superior Cervical Ganglion Sympathetic chain Middle Cervical Ganglion Inferior Cervical Ganglion (Stellate ganglion)* Longus CApitis M. Longus Coli M. Sympathetic Chain sits on top of these muscles Innervated by cervical spinal nerves Cervical Lesion of the Sympathetic Trunk Horner Syndrome = ptosis of the eyelid, constriction of the pupil (miosis), dry face (anhydrosis) Due to lesion or damage to the cervical sympathetic chain Where do the Parasympathetics of the deep neck come from? Vagus Nerve But it’s more than just parasympathetics… Sympathetic Chain Subclavian Artery Common Carotid Artery Specific Branches of Vagus Nerve Vagus Nerve (CNX) Pharyngeal Br. (motor to pharynx & soft palate) Superior Laryngeal Internal Branch (sensory to superior larynx) External Branch (motor to cricothyroid muscle) – that’s it! R Recurrent Laryngeal RIGHT loops under subclavian a. LEFT loops under the aorta (Motor to intrinsic larynx muscles* and sensory to inferior larynx) Recurrent Laryngeal Nerves Right approaches the trachea at a more oblique angle. Right Left Recurrent Laryngeal Nerves and the Inferior Thyroid Artery Inferior thyroid artery and Middle thyroid vein Left Recurrent Laryngeal N (mixed motor & sensory) (Becomes inferior laryngeal n inside the larynx) Laryngeal Nerve Branches Sup. Laryngeal N. Internal Branch Sup. Laryngeal A. & V. Mucosa being pulled back Inferior Laryngeal N. Middle Thyroid V. Inferior Thyroid A. Recurrent Laryngeal N. Lecture Outline • Orientation to the Neck – Review of Cervical Fascia – Boundaries & Subtriangles • Skeletal & Cartilaginous Elements • Muscles of the Anterior Triangle – Muscular Triangle – Submandibular Triangle • Carotid Triangle – Branches of the External Carotid Artery • Veins & Lymphatics • Nerves of the Deep Neck • Viscera in Anterior Neck – Thyroid & Parathyroid – Trachea – Esophagus • Root of Neck – Great Vessel Review – Thyrocervical trunk Thyroid Gland • Endocrine Gland • Located inferior to the thyroid and cricoid cartilage – moves with the larynx when swallowing • Originates as an endodermal proliferation in the developing tongue and then migrates inferiorly • Thyroglossal duct is the passage the gland takes from the base of the tongue to its final destination in the anterior neck. • Two lobes connected by an Isthmus • Thyroglossal duct remnant may exist as pyramidal lobe Ectopic Thyroid Foramen Cecum Blood Supply and Relations • Two (sometimes three) Arteries Superior Thyroid Artery Superior Thyroid Vein – Superior Thyroid Artery – Inferior Thyroid Artery – Thyroid Ima (not pictured) • Three Veins – Superior Thyroid Vein – Middle Thyroid Vein(another slide) – Inferior Thyroid Vein Inferior Thyroid Artery • Surgical relation – Inferior Thyroid A. to Recurrent Laryngeal N. – Cricothyrotomy vs Tracheostomy Inferior Thyroid Vein Recurrent Laryngeal Nerve For Review: Thyroid Ima Artery Thyroid Ima A. 1.5-12% of population Venous Drainage of Thyroid Gland Superior Thyroid Inferior Thyroid Middle Thyroid Internal Jugular Subclavian Parathyroid Glands • Tiny! • Embedded in the posterior surface of the thyroid gland • Separated from thyroid tissue by thick CT capsule • Sometimes, parathyroid tissue can be found independently in the neck or chest. Trachea & Esophagus Relative Positions Shape of Cartilage Rings Anatomical Relationships Cervical Trachea Trachea • Consists of C-shaped rings • Extends from cricoid to bifurcation • Rigid airway Why are the tracheal rings C-shaped rather than complete rings? Esophagus Esophagus Cricopharyngeus (Upper Esophageal Sphincter) is normally contracted to close entry to esophagus. It must relax during swallowing. Position of Trachea and Esophagus Position of Trachea and Esophagus Lecture Outline • Orientation to the Neck – Review of Cervical Fascia – Boundaries & Subtriangles • Skeletal & Cartilaginous Elements • Muscles of the Anterior Triangle – Muscular Triangle – Submandibular Triangle • Carotid Triangle – Branches of the External Carotid Artery • Veins & Lymphatics • Nerves of the Deep Neck • Viscera in Anterior Neck – Thyroid & Parathyroid – Trachea – Esophagus • Root of Neck – Great Vessel Review – Thyrocervical trunk Root of the Neck • Junction between the thorax and the neck. – Superior Thoracic aperture – a passage for all things going from head to thorax and vice versa. • Thoracic duct (Already covered) • Right Lymphatic duct (Already covered) • L Brachiocephalic Trunk • Branches off Subclavian Artery – Thyrocervical Trunk – Internal Thoracic A. – Costocervical Trunk – Vertebral A. Subclavian A. Thyrocervical Trunk Internal Thoracic R. Subclavian A R. Common Carotid Brachiocephalic Trunk Thyrocervical Trunk Branches* Ascending Cervical **Branch of inferior thyroid or Comes off separately Transverse Cervical* Suprascapular* Inferior Thyroid* Subclavian Branches in the Root of the Neck Costocervical Trunk: Deep cervical Superior Intercostal 2 1 Vertebral A 3 Internal thoracic a. Innervation and Action Infrahyoid and Suprahyoid Muscles Suprahyoid Muscles Innervation Action Mylohyoid Nerve to mylohyoid (Off inferior alveolar from mandibular of CN V) Elevates hyoid, floor of mouth and tongue during speaking and swallowing Geniohyoid C1 via hypoglossal Pulls hyoid anterior superiorly Stylohyoid Facial nerve CNVII Elevates and retracts the hyoid Digastric Anterior Belly: Nerve to mylohyoid Posterior Belly: Facial nerve CNVII Elevates hyoid during speaking and swallowing Infrahyoid Muscles Innervation Action Sternohyoid C1-C3 by branch of ansa cervicalis Depresses hyoid after elevation Omohyoid C1-C3 by branch of ansa cervicalis Depresses and retracts hyoid Sternothyroid C2-C3 by branch of ansa cervicalis Depresses hyoid Depresses larynx Thyrohyoid C1 via hypoglossal nerve Depresses hyoid Elevates larynx Superficial Face Frederick Miller, Ph.D. Department of Cell Biology Department of Family and Preventive Medicine 9-17-2024 Superficial Face: Learning Objectives 1. Identify the layers of the scalp and recall the clinical significance of each layer. 2. Identify the location of the parotid gland and trace the duct to its termination in the vestibule of the mouth and recognize the importance of parotid anatomy in diseases affecting the gland like mumps and cancers. 3. Correlate the muscles of facial expression with their actions, their innervation by the facial nerve and their individual contributions to facial functions. 4. Trace the arterial supply and venous drainage of the face. 5. Explain the clinical significance of the danger area of the face. 6. Trace the sensory branches of the trigeminal nerve as they supply touch and pain to the different regions of the face (and parotid gland) and correlate that with sensory exam, anesthesia of the face, and the presentation of herpes zoster. Superficial Face • Lecture Outline – Osteology – Facial features and contents – Scalp – Muscles of facial expression – Sensory innervation of the face (branches of CN V) – Motor innervation of the face (branches of CN VII) – Branches of the facial artery – Venous drainage of the face and lymphatics Superficial Face: The Cranium • Neurocranium - Brain and meninges Cranial nerves Vasculature • Viscerocranium - Facial bones - Orifices - Viscera Superficial Face: Osteology Frontal • Viscerocranium Glabella Supraorbital foramen – Orbits – Nose and nasal cavity Sphenoid – Oral cavity • Maxillae Superciliary arch Nasal Infraorbital foramen • Mandible – Houses lower teeth – moveable Zygoma Maxillae – Houses upper teeth – Fixed Mental foramen Orbital part frontal bone Mandible Superficial Face • Lecture Outline – Osteology – Facial features and contents – Scalp – Muscles of facial expression – Sensory innervation of the face (CN V) – Motor innervation of the face (CN VII) – Branches of the facial artery – Venous drainage of the face and lymphatics Superficial Face: Regions of the Face Supraorbital Ridge Superficial Face Epicanthal fold • Facial Features Lateral canthus – Features are constant – Lots of variations of each type of feature from individual to individual Root Medial canthus Ala Nasolabial Fold Labial Commisure Apex Nares Philtrum Vermilion Border Mental Protuberance Superficial Face: Borders and Contents A. Borders 1. Forehead (hairline) 2. Ant. border of external ear 3. Chin B. General Contents 1. Eyes 2. Nose 3. Mouth 4. Muscles of Face 5. Buccal Fat Pad 6. Parotid Gland 7. Trigeminal Nerve branches 8. Facial Nerve branches 9. Facial Arteries & Veins Superficial Face: Parotid Gland • Para – beside / Otic – ear • Superficial to masseter • Innervation: – Parasympathetic - CN IX – Sensory: skin and capsule • Great auricular n. (C2, C3) • Auriculotemporal n. (CN V3) • Parotid (Stensen’s) duct • Found in parotid substance: – Parotid plexus of CN VII – External carotid / Superficial temporal a. – Retromandibular vein Parotid duct Buccinator Parotid gland Superficial Face • Clinical correlation – Parotitis (Parotiditis) – Mumps • Viral infection (paramyxovirus) • Manifests as parotitis – MMR vaccine • 12-15 months • 4-6 years – Frey’s syndrome Swollen parotid gland Superficial Face • Lecture Outline – Osteology – Facial features and contents – Scalp – Muscles of facial expression – Sensory innervation of the face (CN V) – Motor innervation of the face (CN VII) – Branches of the facial artery – Venous drainage of the face and lymphatics Superficial Face - Scalp SCALP 5 Layers: 1. Skin 2. Connective tissue Subcutaneous Tissue 3. Aponeurosis 4. Loose Areolar Connective Tissue 5. Periosteum Superficial Face - Scalp Relationship of the scalp to calvaria and meninges Emissary vein – Dural sinuses – Emissary veins Scalp – Arachnoid granulations – Foveolae Dura mater Arachnoid granulation Dura mater Superior sagittal sinus Superficial Face – Scalp Muscles Gala aponeurotica • Epicranial aponeurosis – Occipitofrontalis – Temporoparietalis – Auricularis muscles • Innervated by motor branches of CN VII Frontalis Auricularis Occipitalis Superficial Face • The temporalis is not considered a scalp muscle. • The temporalis is considered a muscle of mastication and is deep to the temporalis fascia. • The temporalis is innervated by the deep temporal nerves (CN V3). Temporalis Superficial Face • Lecture Outline – Osteology – Facial features and contents – Scalp – Muscles of facial expression – Sensory innervation of the face (CN V) – Motor innervation of the face (CN VII) – Branches of the facial artery – Venous drainage of the face and lymphatics Superficial Face – Overview Muscles • Muscles of Facial Expression – Orbit of the eye – Nose and nostrils – Oris: lips, cheek, mouth – Also: scalp, neck, external ear • No deep membranous fascia in the face • Muscles insert directly into the overlying skin • Primary function: Sphincters and Dilators • Derived from: Mesoderm 2nd pharyngeal arch • Innervation: motor branches of CN VII Muscles of Facial Expression • Scalp (aponeurotic) muscles – Occipitofrontalis – Temporoparietalis – Auricularis muscles • Innervated by motor branches of CN VII – Occipitalis: post. auricular – Frontalis: temporal branches – TP: temporal branches Gala aponeurotica Frontalis Auricularis Occipitalis Muscles of Facial Expression Associated with: Orbit Nose Oris Frontalis Orbicularis oculi ProcerusCorrugator supercillii Orbital Palpebral Attach to the skin Orbicularis Orbital part – closes eyelid tightly Palpebral part – closes eyelid gently Innervated by motor branches of CN VII Orbicularis oculi: Temporal / Zygomatic Corrugator supercillii: Temporal branches Muscles of Facial Expression Associated with: Orbit Nose Oris Nasal muscle group Attach to the skin Levator labii superioris Procerus alaque nasi Nasalis Innervated by CN VII Procerus: Temporal, Zygomatic) Nasalis: Buccal (some zygomatic) Muscles of Facial Expression Associated with: Orbit Nose Oris Levator labii superioris alaque nasi Buccolabial group Attach to the skin Zygomaticus minor Zygomaticus major Levator labii superioris Risorius Innervated by CN VII (see specifics in notes below) Depressor anguli oris Depressor labii inferioris Levator anguli oris Buccinator Masseter Orbicularis oris Mentalis Muscles of Facial Expression Lateral View Frontalis Nasalis Auricularis Occipitalis Levator labii superioris alaque nasi Levator labii superioris Risorius Zygomaticus minor Zygomaticus major Depressor anguli inferioris Platysma Superficial Face • Lecture Outline – Osteology – Facial features and contents – Scalp – Muscles of facial expression – Sensory innervation of the face (CN V) – Motor innervation of the face (CN VII) – Branches of the facial artery – Venous drainage of the face and lymphatics Overview Innervation of the Face • Sensory innervation – Trigeminal Nerve (CN V) – 3 main divisions • Motor innervation – Facial Nerve (CN VII) • Salivary gland innervation – Parotid: Glossopharyngeal Nerve (CN IX) – Submental and submandibular: Facial N. (CN VII) Sensory Innervation of the Face Branches of the Trigeminal N. (CN V) Ophthalmic division (V1) a. Supraorbital b. Supratrochlear c. Lacrimal d. Infratrochlear e. External Nasal Ophthalmic division Maxillary division (V2) a. Zygomaticotemporal Maxillary division b. Zygomaticofacial c. Infraorbital Mandibular division (V3) a. Auriculotemporal Mandibular division b. Buccal c. Mental Great Auricular Nerve (C2,3) Transverse Cervical Nerve (C2,3) Trigeminal ganglion Location of the Trigeminal Ganglion CN V and Ganglion V1 - ophthalmic V2 - maxillary V3 - mandibular Sensory Innervation of the Face Auriculotemporal Lacrimal Supraorbital Supratrochlear V1 Infratrochlear Ext. nasal V2 Zygomatico temporal Zygomatico facial Infraorbital Buccal V3 Posterior cervical rami Greater Occipital Nerve (C2) Third Occipital Nerve (C3) Mental Anterior cervical rami Great Auricular Nerve (C2,3) Lesser Occipital Nerve (C2,3) Sensory Nerves of the Face – CN V Supraorbital Supratrochlear Anterior ethmoid Ophthalmic division (V1) Frontal nerve a. Supraorbital b. Supratrochlear Nasociliary a. post. ethmoid b. anterior ethmoid 1. external nasal c. infratrochlear Lacrimal Frontal nerve Nasociliary V1 Infratochlear Lacrimal Ophthalmic division enters the orbit through the superior orbital fissure Sensory Nerves of the Face – CN V Maxillary Nerve Trigeminal ganglion Maxillary division (V2) Infraorbital Nerve a. Zygomatic nerve i. Zygomaticotemporal ii. Zygomaticofacial b. Infraorbital Infraorbital fissure Infraorbital Nerve Sensory Nerves of the Face – CN V Mandibular division (V3) a. Auriculotemporal b. Buccal c. Inf. Alveolar i. Mental Trigeminal ganglion V3 Buccal Ariculotemporal n. Note: the auriculotemporal, buccal branch, and inferior alveolar Inferior alveolar n. nerves of the mandibular division will be seen in the deep face dissection. Mental n. Sensory Nerves of the Face Cutaneous Nerves emerging onto the face (anterior view) Trigeminal Nerve (CN V) 1. Supratrochlear (V1) 2. Supraorbital (V1) 3. Zygomaticotemporal (V2) Zygomaticofacial (V2) 4. Infraorbital (V2) 5. Buccal (V3) 6. Auriculotemporal (V3) 7. Mental (V3) 2 1 3 6 3 4 5 7 Parotid duct Superficial Face • Clinical Correlation: CN V • Herpes zoster ophthalmicus (Shingles) – Post chicken pox, latent zoster resides in sensory ganglia – Reactivation of Varicella Zoster Virus (VZV) – What ganglia? – Distribution of vesicles along dermatomes Superficial Face • Lecture Outline – Osteology – Facial features and contents – Scalp – Muscles of facial expression – Sensory innervation of the face (CN V) – Motor innervation of the face (CN VII) – Branches of the facial artery – Venous drainage of the face and lymphatics Motor Nerves of the Face Temporal Posterior auricular Zygomatic Facial Nerve (CN VII) Posterior trunk Posterior auricular Anterior trunk Temporofacial Buccal 1. Temporal 2. Zygomatic Marginal mandibular 3. Buccal Cervicofacial 1. Buccal 2. Mandibular 3. Cervical To Zanzibar By Motor Car or …….. Cervical Exits stylomastoid foramen Motor Branches of the CN VII (Facial) Temporal Zygomatic Buccal Mandibular Cervical Superficial Face • Facial nerve review • Clinical Correlation: – Bell’s Palsy • Unilateral facial paralysis • Due to inflammation of the facial nerve • Viral infection, trauma, idiopathic Superficial Face • Lecture Outline – Osteology – Facial features and contents – Scalp – Muscles of facial expression – Sensory innervation of the face (CN V) – Motor innervation of the face (CN VII) – Branches of the facial artery – Venous drainage of the face and lymphatics Arterial Supply to Face Superficial Temporal Ext. carotid artery 1. Facial artery a. Inferior labial b. Superior labial c. Lateral nasal d. Angular 2. Superficial temporal Transverse facial (= X) 3. Posterior auricular 4. Occipital 5. Maxillary Infraorbital Mental Angular Sup. labial Inf. labial Facial Post. auricular X Occipital Maxillary Ext. carotid Int. carotid artery Ophthalmic artery 1. Supratrochlear 2. Supraorbital Common carotid Superficial Face • Lecture Outline – Osteology – Facial features and contents – Scalp – Muscles of facial expression – Sensory innervation of the face (CN V) – Motor innervation of the face (CN VII) – Branches of the facial artery – Venous drainage of the face and lymphatics Veins of the Face Supraorbital Supratrochlear Superficial temporal Angular 1. Supraorbital v. Infraorbital 2. Supratrochlear v. 3. Superficial Temporal v. Sup. labial 4. Retromandibular v. 5. Facial v. 6. Ophthalmic v. (not labeled) Inf. labial a. superior b. inferior Facial 7. Infraorbital v. (not labeled) Post. auricular Occipital Retromandibular EJV IJV Note: there are many variations for the veins of the head and neck. Most texts show the external jugular formed by union of the retromandibular and posterior auricular veins. Veins of the Face Cavernous sinus Superior ophthalmic v. Inferior ophthalmic v. Pterygoid plexus Retromandibular Facial v. Deep facial v. IJV Infections of the face and scalp can be very serious as the superficial veins are in communication with the deep veins of the face and cranium at several locations. Lymphatics of the Face Mastoid nodes Parotid nodes Submental nodes Occipital nodes Submandibular nodes Deep cervical nodes Right lymphatic trunk Superficial View Deep View Superficial Face • Lecture Outline – Osteology – Facial features and contents – Scalp – Muscles of facial expression – Sensory innervation of the face (CN V) – Motor innervation of the face (CN VII) – Branches of the facial artery – Venous drainage of the face and lymphatics Dissection of the Superficial Face Superficial Temporal A&V Auriculotemporal N Orbicularis Oculi Transverse Facial A Parotid Gland Parotid Duct Branches of the facial N Greater Auricular N External Jugular V Platysma M. Mentalis M. Facial A&V Branch CN V Nerve Location Innervates Ophthalmic (V1) Frontal nerve Supraorbital Supraorbital notch Forehead, Scalp Frontal nerve Supratrochlear FH above trochlea Forehead Nasociliary / ant. ethmoid External nasal Side of nose Ala and dorsum of nose; vestibule Nasociliary Infratrochlear Below eye Medial lower eyelid/conjunctiva Skin side of the nose Lacrimal Superolateral orbit Lateral upper eyelid;lat conjunctiva, part lacrimal gland Infraorbital Orbital floor Inf. eyelid, cheek below eye, ala nose, upper lip Zygomatic Zygomaticotemporal Skin from zygomatic region to anterior temporal region Zygomatic Zygomaticofacial Skin over cheekbone Auriculotemporal Deep to ramus of mandible Skin anterior to auricle, skin of posterior temporal region Maxillary (V2) Mandibular (V3) Origin External carotid Internal carotid Branch of carotid Facial artery Artery Location Supplies Inferior labial Deep to orbicularis oris Lower lip Superior labial Deep to orbicularis oris Upper lip/ala nose Some - nasal septum Angular Along nose to angle of eye Cheek, inferior eyelid Superficial temporal Anterior to ear; passes through parotid Muscles/skin of frontal & temporal scalp Posterior auricular Deep to parotid to mastoid and back of ear Scalp posterior, inferior, and medial to the ear. Auricle Occipital Runs with C2 Posterior scalp to vertex Transverse facial Runs superficial to masseter Parotid gland and duct; muscles and skin of face Maxillary/inferior alveolar Mental Mental foramen Muscles/skin chin Ophthalmic Supraorbital Supraorbital foramen Muscles/skin forehead Supratrochlear Supraorbital notch Muscles/skin Extra - Central vs. Peripheral CN VII Lesions • Upper motor neurons – Cell bodies in cerebral cortex or brainstem – Synapse on lower motor neurons in the midbrain, brainstem or spinal cord – Upper motor neurons decussate (cross over) • Lower motor neurons – Cell bodies are in nuclei in the midbrain, brain stem or the ventral horn of the spinal cord – Innervate muscles directly (SME) – Lower motor nerves innervate muscles on the ipsilateral side of the body Extra - Central vs. Peripheral CN VII Lesions • Upper Motor Neurons (UMNs) to Face: • Upper Face (Upper Eyelid and Forehead): • UMNs to the upper face split before crossing over in the brainstem. • As a result, muscles of the upper face receive bilateral innervation from the UMNs of both the left and right cerebral cortices. • UMNs synapse on lower motor neurons in both the left and right facial motor nuclei in the brainstem. • The lower motor neurons innervate the muscles of the upper face (e.g., forehead) on both sides. • Lower Face (Below the Eyes): • UMNs to the lower face do not split before crossing over. • Muscles of the lower face are controlled by UMNs from the contralateral cerebral cortex. • UMNs synapse on lower motor neurons in Peripheral VII Lesion the contralateral facial motor nucleus. • Thus, the lower motor neurons innervate the muscles of the lower face on only one side. Central Lesion Extra - Central vs. Peripheral CN VII Lesions Lesions of Upper Motor Neurons (UMNs): • Effects: UMN lesions typically spare the forehead muscles due to bilateral innervation. • Findings: • • • The patient can wrinkle the forehead on both sides. The patient can close both eyes. Lesion Location: Central lesion, such as those caused by an ischemic stroke affecting the motor cortex or its pathways. Lesions of Lower Motor Neurons (LMNs): • Effects: LMN lesions result in ipsilateral paralysis of both the upper and lower face. • Findings: • • • The patient cannot wrinkle the forehead on the affected side. The patient cannot close the eye on the affected side. Lesion Location: Peripheral lesion, such Peripheral VII Lesion as Bell’s Palsy, affecting the facial nerve. Central Lesion