CRITICAL JOURNAL REPORT (CJR)
BIOCHEMISTRY
Lecturer: Rahmad H. Gultom, S.Pd., M.Pd
By: Yesohaya Divina Kaban (4223141025)
BIOLOGY EDUCATION STUDY PROGRAM
FACULTY OF MATH AND SCIENCE
UNIVERSITAS NEGERI MEDAN
SEPTEMBER 2023
Journal Identity
Journal title
Glycine Metabolism and Its Alterations in Obesity and
Metabolic Diseases
Authors
Anaïs Alves, Arthur Bassot, Anne-Laure Bulteau, Luciano
Pirola and Béatrice Morio
DOI
10.3390/nu11061356
Volume, No.
Vol. 11, No. 1356
Pages
Publication Year
Publisher
1-28
2019
Nutrients
Critical Journal Review
No
1
Matter
Research purposes
2
Research Methodology
3
Research result
Article Page 1
This research aims to discuss the role of glycine in
various physiological processes and metabolic
pathways, as well as highlight its importance in
conditions such as diabetes, obesity and liver
disease. This research also explores glycine
metabolism, including its synthesis, conjugation,
and transport, as well as potential therapeutic
targets in measuring insulin secretion,
inflammation, and cancer cell proliferation. This
article also emphasizes the impact of glycine
supplementation on oxidative stress, insulin
sensitivity, and metabolic health, suggesting its
potential benefits in improving various aspects of
health.
This research method involves giving methyldonor supplements, such as betaine, to mice that
have been fed a high-fat diet for several weeks.
The
effects
were
evaluated
through
glucose/insulin tolerance tests and hyperglycemiceuglycemic clamps to measure insulin resistance
and glucose homeostasis. In addition, liver fat
deposition was also measured using chloroformmethanol extract.
Based
on
research
results,
glycine
supplementation has been shown to improve
insulin response, glucose tolerance, and insulin
sensitivity in patients with obesity and metabolic
disorders. Decreased plasma glycine levels are
4
Conclusion
5
Research findings
associated with conditions such as NAFLD,
obesity, and insulin resistance. Reduced glycine
availability in obesity may be due to decreased
intestinal absorption, decreased biosynthesis, and
increased catabolism or urinary excretion. Diet
and gut microbiota composition may also
influence glycine availability. Glycine also plays
a role in regulating insulin secretion,
inflammation, and cancer cell proliferation.
Further research is needed to understand the
impact of glycine supplementation on metabolic
disorders such as type 2 diabetes. Glycine has
potential as a beneficial supplement in improving
metabolic health, especially in conditions such as
diabetes and non-alcoholic steatohepatitis. Further
research is needed to understand the role of
glycine in metabolic conditions and the potential
therapeutic interventions that may be associated.
Based on the summary of the article, it can be
concluded that glycine has an important role in
various metabolic and physiological processes in
the body. Glycine supplementation has been
shown to improve insulin response, glucose
tolerance, and insulin sensitivity in patients with
obesity and metabolic disorders. Decreased
plasma glycine levels are associated with
conditions such as NAFLD, obesity, and insulin
resistance. Reduced glycine availability in obesity
may be due to decreased intestinal absorption,
decreased biosynthesis, and increased catabolism
or urinary excretion. Diet and gut microbiota
composition may also influence glycine
availability. Glycine also plays a role in regulating
insulin secretion, inflammation, and cancer cell
proliferation. Further research is needed to
understand the impact of glycine supplementation
on metabolic disorders such as type 2 diabetes.
Glycine has potential as a beneficial supplement in
improving metabolic health, especially in
conditions such as diabetes and non-alcoholic
steatohepatitis. Further research is needed to
understand the role of glycine in metabolic
conditions and the potential therapeutic
interventions that may be associated.
Glycine supplementation has been shown to
improve insulin response, glucose tolerance, and
insulin sensitivity in patients with obesity and
metabolic disorders. Decreased plasma glycine
levels are associated with conditions such as
NAFLD, obesity, and insulin resistance. Reduced
6
Things that have the
potential to be
developed
glycine availability in obesity may be due to
decreased intestinal absorption, decreased
biosynthesis, and increased catabolism or urinary
excretion. Diet and gut microbiota composition
may also influence glycine availability. Glycine
also plays a role in regulating insulin secretion,
inflammation, and cancer cell proliferation.
Further research is needed to understand the
impact of glycine supplementation on metabolic
disorders such as type 2 diabetes. Glycine has
potential as a beneficial supplement in improving
metabolic health, especially in conditions such as
diabetes and non-alcoholic steatohepatitis. Further
research is needed to understand the role of
glycine in metabolic conditions and the potential
therapeutic interventions that may be associated.
Several things that have the potential to be
developed based on research findings are:
1. Development of pre- and probiotics that
influence the bioavailability of glycine for the
body.
2. Further research into the role of glycine in
metabolic health and metabolic disorders such as
type 2 diabetes.
3. A deeper understanding of glycine metabolism
in relation to cancer, especially in regulating the
methylation status of cancer cells.
4.
Research
into
potential
therapeutic
interventions related to glycine metabolism in
certain metabolic conditions.