Supplement Figure 1
The expression levels of 6 Genes by Cluster
Vertical axis indicates gene type. Horizontal axis shows relative
expression levels of genes.
Red bar indicates the range of gene expression in Cluster1.
Green bar indicates the range of gene expression in Cluster2.
Blue bar indicates the range of gene expression in Cluster3.
The expression levels of genes in each Cluster were analyzed with the
Wilcoxon rank sum test.
Supplement Figure 2
TMB value for six genetic variants using the
cBioportal database (N=7661)
The vertical axis indicates TMB.
The horizontal axis of upper graph indicates altered genes and unaltered genes.
The horizontal axis of row graph indicates genes.
Alter means genetic mutation.
Supplement Table I
Clinicopathological characteristics of MMR
χ² tests were conducted to analyze associations among MMR protein expression and
clinicopathological characteristics.
Age was analyzed with the Wilcoxon rank sum test.
MMR, mismatch repair; dMMR, deficient MMR; pMMR, proficient MMR.
＊ Statiscally significant
Supplement Table II
Clinicopathological characteristics of TIL
χ² tests were conducted to analyze associations among number of TIL and
clinicopathological characteristics.
Age was analyzed with the Wilcoxon rank sum test.
TIL, tumor-infiltrating lymphocytes; TIL-H, TIL- High; TIL-L, TIL-Low.
＊ Statiscally significant
Supplement Table III Gene List
(A) DNA repair mechanisms (left) and genes corresponding to repair
mechanisms(right)
MMR：Mismatch excision repair; HR：Homologous recombination; NER:Nucleotide
excision repair; DR:Direct reversal of damage;
BER:Base excision repair; NHEJ:Non-homologous end-joining
(B) Assay ID
Sup Table IV
Cases of TMB value measurement
MMR, mismatch repair; dMMR, deficient MMR; pMMR, proficient MMR.
TIL, tumor-infiltrating lymphocytes; TIL-H, TIL- High; TIL-L, TIL-Low.
TMB, tumor mutation burden.
TMB≧10 muts/Mb defines high.TMB<10 muts/Mb defines low.