GSTS : FINALS 0581 - Science, Technology, and Society [BS PSYCHOLOGY 1] MODULE 8: BIODIVERSITY, CLIMATE CHANGE AND A HEALTHY SOCIETY “Biodiversity is the variation among living organisms from different sources including terrestrial, marine and desert ecosystems, and the ecological complexes of which they are a part.” ● ● ● ● BIODIVERSITY : HEALTH AND MEDICINE PLANTS LEVELS OF BIODIVERSITY Genetic Diversity Variations among organisms of the same species Species Diversity Variety of species within a particular region Ecological Diversity Network of different species in an ecosystem and their interaction with one another. PHILIPPINES: A MEGADIVERSE COUNTRY ● ● Megabiodiversity: refers to top biodiversity-rich countries. The concept is used to highlight awareness of conservation issues around the world. To qualify as a megadiverse country: must have a high level of endemism and species diversity, as well as have marine ecosystem along its border. PHILIPPINE FLORA AND FAUNA ● ● Flora: refers to the plant life Fauna: refers to the animal life Conservation International: Biodiversity Hotspots (2006) ● Plants: 9253 ● Birds: 535 ● Freshwater fishes: 281 ● Reptiles: 237 ● Mammals: 167 ● Amphibians: 89 BENEFITS OF BIODIVERSITY Utilitarian Value Intrinsic Value - basic needs human obtain from biodiversity ● Source of Food ● Medicine ● Energy ● Aesthetic and cultural benefits ● Ecosystem services - potential usefulness of biodiversity for human beings ● Inherent right of species to exist Regulate Climate and Flood Regulate Pollution Regulate Water and air quality Regulate Decomposition of Waste USES Cupressus sempervirens Cypress Cough, colds, inflammation Salvia apiana California sage Aids in child birthing, boost immune system Alhagi maurorum Camel thorn Contains sugar (manna) Diuretic, diaphoretic,laxative, expectorant, Gastroprotective, antiseptic, anti-diarrhea Ligusticum scoticum Scottish lovage Uterine disorder Willow tree Salicyclic acid Anti-inflammatory Papaver somniferum Opium poppy Morphine, Pain killer Digitalis purpuruea Foxglove Heart condition Pennicilum Fungi Penicillin, Antibiotic Pilocarpine Xerostomia, Dry mouth Cinchona succiruba Pav. Ex Klotzsch Malaria Clinopodium douglasii Peppermint, Yerba buena relieving pain and body aches Blumea balsamifera Sambong diuretic herb for treating urine stones and edema Vitex negundo Lagundi cough and asthma. Moringa oelifera Malunggay effective remedy against many kinds of ailments BIODIVERSITY: AGROBIODIVERSITY ● WHAT BIODIVERSITY PROVIDE AND DO : ● ● ● ● Food Medicine Energy Air and Water ● ● ● “All the component of biological diversity associated with food and agriculture, and all components of biological diversity that related to agricultural ecosystems.”-Convention on Biological Diversity (CBD) Source of food and nutrition (human, livestock & cultivated plants) Medicine and health value Ecosystem services (pollination, food chain) brii | 1 ● ● ● ● Genetic resources (plant/animal) Knowledge (taxonomy) Economic value Socio-economic to support livelihood BIODIVERSITY: ENERGY Stone Age1000 BC Chinese begin burning coal for heating and cooking 400 BC Europeans build wheels in rivers to harness hydropower 100 AD Persian built first windmills as source of wind energy 1700 - 1800 British discovered burning coal to coke which has high fuel content 1820 First natural gas was drilled in Fredonia, NY 1830 Electric generator was developed from Michael Faraday’s discovery of electromagnetism 1850 First oil well was drilled which led to distillation of kerosene from petroleum 1860 Augustine Mouchot developed the first solar energy generator 1892 First use of geothermal energy to heat building in 1942 First nuclear fission reactor ENVIRONMENTAL RISKS OF ENERGY CONSERVATION ● Nuclear reactor accident ● Oil spill ● Coal ash spill ● ● ● ● ● ● ● ● POSITIVE IMPACTS OF ENERGY *Without energy and power, most technologies would not exist or work. ADVERSE EFFECTS ON BIODIVERSITY Wildlife mortality Habitat loss Fragmentation Noise & light pollution Invasive species Changes in carbon stock Changes in water resources 1942 Mangrove as flood barrier BIODIVERSITY: AIR AND WATER TREATMENT ● ● PRIMARY POLLUTANTS ○ Carbon Monoxide (CO) ○ Sulfur dioxide (SO2) ○ Ammonia (NH3) ○ Nitric Oxide (NO) ○ Nitrogen Dioxide ( NO2) ○ Volatile Organic Compounds (VOCs) ○ Particules (PM) SECONDARY POLLUTANTS ○ Sulphur trioxide (SO3) ○ Sulphuric Acid (H2SO4) ○ Ammonium (NH4) ○ Ozone (O3) ○ Nitric Acid (HNO3) ○ Hydrogen Peroxide (H2O2) ○ Particulates (PM) BIODIVERSITY:PROTOCOLS Montreal Protocol Phasing out of ozone-depleting gases (hydrofluorocarbons) Kyoto Protocol Fight global warming by reducing greenhouse gases Cartagena Protocol & Convention on Biological Diversity Protecting biological diversity from potential risks posed by living modified organisms resulting from modern biotechnology Philippine Environmental Jurisprudence Philippine Laws CLIMATE CHANGE 6 MAJOR THREATS TO BIODIVERSITY 1. Climate Change Increase in the temperature of the atmosphere has major effects on the environment such as seasons, rising of the sea levels, and glacial retreats 2. Habitat Loss and Degradation May be caused by natural events like natural calamities and geological events or anthropogenic activities like deforestation and man induced climate change 3. Pollution Be it water, air, or land pollution, all forms of pollution appear to be a threat to all life forms on Earth 4. Invasive Spaces An exotic or unnatural species can be any kind of organism that has been introduced to a foreign habitat. This introduction can cause major threats to the native species BIODIVERSITY: WATER STORAGE AND FLOOD CONTROL 2000 BC Groundwater and wells for irrigation 312 BC Aqueducts for flood ways were built by Romans & Greeks 1900 Dams were developed to maintain water supply 2000 - present Diversion canals Flood barriers (levees) Land use zoning Coastal defenses brii|2 5. Overexploitation 6. Other Potential Threats Refers to the act of over harvesting species and natural resources at rates faster than they can actually sustain themselves in the wild ● Reduction of Biodiversity Epidemics and infectious diseases of wildlife such as Ebola virus disease, infectious bursal disease, and flu affect wildlife and biodiversity WHAT IS CLIMATE CHANGE ? ● number of trees able to capture carbon dioxide from the atmosphere. Climate Change: change in the average temperature and cycles of weather over a long period of time. Since 1880, scientists have kept thermometerbased records of the global surface temperature. WHO CAUSES CLIMATE CHANGE ? ● ● ● ● ● The planet is becoming warmer; the climate is changing. ● WHAT CAUSES CLIMATE CHANGE? ● ● ● ● ● ● Carbon dioxide (CO2), methane (CH4) and water vapor (H2O) are greenhouse gasses that are found in the atmosphere. Energy: travels from the Sun to the Earth as short wave radiation. It does not interact strongly with the greenhouse gas molecules so it reaches the Earth’s surface. The Earth’s surface emits long wavelength radiation. This does interact with the greenhouse gas molecules. The greenhouse gas molecules: absorb some of the energy, trapping it in the atmosphere. Greenhouse effect: Causes the rise in temperature in which the higher the proportion of greenhouse gasses in the atmosphere, the more radiation is absorbed. Climate Change: caused gradually by natural processes or suddenly by large events, such as a massive meteorite strike or volcanic activity. Rapid climate change is due to three main human activities: Burning of Fossil Fuels for heating and cooking, generating electricity and powering vehicles releases carbon dioxide into the atmosphere. Deforestation releases carbon dioxide and reduces the The 50 least developed countries are thought to have contributed 1% of the greenhouse gasses that have caused global warming. The USA, the EU and China alone have contributed around 60%. WHY IS CLIMATE CHANGE A PROBLEM? ● ● creates an unstable ecosystem. Nature loss leads to ecosystems that are less able to capture carbon from the atmosphere and less resilient to rising temperatures. Over millions of years, species become adapted to survive in the conditions in which they live. Stable climate: allows living things to thrive. If the climate changes quickly, organisms don’t have enough time to adapt to new conditions and may no longer be able to survive. Climate Change: disrupts weather patterns and causes extreme weather events to become more common. These include hurricane activity, droughts and floods. As the global temperature has increased, so has the number of reported natural disasters Rising Sea Levels: Rising temperatures are causing sea levels to increase. The rising water can cover coastal areas, destroying habitats and displacing whole populations from low-lying areas. Ice Melt When the atmosphere and ocean get warmer, ice sheets and glaciers melt, resulting in the addition of fresh water to the ocean. Thermal Expansion As ocean water gets warmer, it expands, causing sea levels to rise. ● ● ● The increase in global temperatures is causing a reduction in sea ice. This causes problems for animals that depend on the ice to hunt, mate and sleep. Acting quickly to keep the temperature rise to minimum is extremely important for humans and wildlife. Coral Bleaching Species Loss Drought Rise in Sea Levels brii|3 CLIMATE CHANGE AND HEALTH Intersecting Inequalities • may face exclusion or discrimination because they fall into multiple disadvantaged groups, for example, Black women, disabled LGBTQ+ people or poor children. CLIMATE JUSTICE Climate Justice looking at the climate crisis from the perspective of social justice. Solutions need to not only curb climate change; they need to protect and empower the most vulnerable groups of people too. Responsibility to consider the most vulnerable when planning climate action. Remember, these groups of people contribute to climate change the least. This means putting the people and communities that are most vulnerable to the impact of climate change at the heart of development. MENTAL HEALTH AND WELL-BEING ● Impact of Climate Change on Physical, Mental, and Community Health Medical and Physical Health • changes in fitness and activity level • heat-related illness • allergies • increased exposure to waterborne and vector-borne illness Mental Health • stress, anxiety, depression, grief, sense of loss • strains on social relationships • substance abuse • post-traumatic stress disorder Community Health ● Everyone will feel the effects of climate change Wealth of prosperous countries: has come from activities which contribute to greenhouse gas emissions; allows these countries to protect themselves from the effects of climate change. Poorer countries are less able to adapt to climate change and therefore suffer the most from its effects; less able to develop because they need to focus on addressing the challenges caused by climate change. Governments • can make laws and policies that reduce the amount of greenhouse gas emissions. Businesses • can change their processes to run more sustainably. We Social Justice ● ● ● ● The transition to a low-carbon economy in the years ahead brings with it many opportunities. Innovation: process of turning an idea into a solution that solves a problem Transitioning to low-carbon economies will provide lots of opportunity for innovation. New job sectors will be created and new skills will be valued in the jobs market. COP26 ● • concept of fairness • to fairness within a society • People should have equal access to wealth, health, opportunities and privileges within a society. All humans should have the right to a certain standard of living, including a healthy diet, access to clean water, shelter, clothing, education and healthcare. • can all make choices in our own lives that reduce our carbon footprint • use our voices to let businesses and governments know that we want them to act quickly NEW OPPORTUNITIES SOCIAL JUSTICE Justice will not work if we do not address social justice issues. WHO CAN FIX IT? • increased interpersonal aggression • increased violence and crime • increased social instability • decreased community cohesion MENTAL HEALTH AND WELL-BEING ● ● Climate Solutions ● 197 countries (parties) have signed up to the United Nations Framework Convention on Climate Change (UNFCCC). ○ aims to prevent human activity from causing dangerous levels of climate change. COP: Conference of Paris ○ look at the current state of the climate and discuss the actions they will take to address climate change. brii|4 WHAT HAPPENS AT COP26? ● ● ● ● ● ● ● In 2015: at COP21 in Paris, the nations signed an agreement that set out an ambitious plan to tackle climate change. Paris Agreement: nations agreed to act together to restrict global temperature increases to 2°C and begin efforts to limit warming to 1.5°C. To do this we will need to reach ‘net zero’ by 2050. This means that any carbon emissions will need to be balanced by removing carbon dioxide from the air. The Paris Agreement instructed: governments to renew their commitment to lowering their emissions every five years, each time becoming more ambitious. New Nationally Determined Contributions (NDCs):due to be set by countries at COP26] Global carbon dioxide emissions: continued to rise after The Paris Agreement, and are now 62% higher than they were in 1990. Global net CO2 emissions need to fall by 45% from 2010 levels by 2030 to limit global warming to 1.5°C. improving the sustainability of all aspects of our school life. • The changes that we make as a school are seen by lots of people in our local community. This means that we can influence positive change to spread through society. MODULE 9: IMPACTS OF RISK ASSESSMENTS OF NANOTECHNOLOGY Nano • Expresses a very tiny amount or size • A unit which means one billionth or 10^-9 • 1 inch=25,400,000 nanometer • A sheet of newspaper= 100,000 nanometers thick Nanotechnology • Study and use of structures between 1-100 nanometers in size • Refers to the design, characterization, production and application of structures, devices and systems by controlling shape and size at nanometre scale. Nanoscience • Deals with the materials that are very small using specialized microscopes and nanodevices. • The study of phenomena and manipulation of materials at atomic, molecular and macromolecular scales, where properties differ significantly from those at a larger scale SUSTAINABLE DEVELOPMENT GOALS WHY IS THERE SO MUCH INTEREST/CONCERN ABOUT NANOTECHNOLOGY? ● ● ● ● ● In the same year that the Paris Agreement was signed, 17 Sustainable Development Goals (SDGs) were adopted by all United Nations Member States. The 17 goals set out all of the things that need to be achieved to protect the planet and ensure that all people enjoy peace and prosperity. Sustainable Development: development means that we need to reach this vision of the world without preventing future generations from also being able to meet their needs. We need to be able to continue each action forever without running out of resources or causing damage that stops us from being able to carry on. WHAT CAN WE DO? Speak Up • Make sure that world leaders know we are counting on them. • Your MP is the person that represents your community’s needs and views in parliament. • Reach out to businesses and our local council if we feel like they need to do things differently too. Act • As a school community, we can help in the fight against climate change and biodiversity loss by ● ● ● Huge gaps in knowledge concerning the possible risks Enormous potential Difficulty in detecting and removing Absence of regulation METHODS OF MAKING NANOPARTICLES Top Down Cut objects smaller and smaller until attain size needed. Bottom Up Add atoms together one by one to attain correct property. APPLICATIONS OF NANOTECHNOLOGY ● Nanotechnology: helping to considerably improve, even revolutionize, many technology and industry sectors ○ Information Technology ○ Medicine ○ Homeland Security ○ Food and Food safety ○ Energy and Transportation ○ Environmental Science Environmental Remediations • Radioactive waste cleanup (titanate nanofibers and nanotubes) • Oil spill clean up (nanofabric “paper towel” from tiny wires of brii|5 potassium manganese oxide) • Groundwater cleanup (iron particles) Medical Field Other Applications Agriculture Other Applications Philippines DOST Nanotech Lab • Silver nanoparticles has antimicrobial properties • Drug delivery (nanobots, molecular scale workers) • Gold nanoparticles and nanoflares (detection of cancer cells and gene targets) • Regenerative medicine (graphene nanoribbons) – repair damage tissue • Reduction of pollutants (silver nanoclusters to reduce propylene oxide) • Generation of electricity (silicon nanowires in solar cells) • Heat-resistant & self-cleaning surfaces like floors and benchtops • Silicon dioxide and titanium dioxide for water & stain resistant surfaces RISK ASSESSMENT PROBLEMS ● ● ● ● Very difficult to detect without sophisticated equipment Potential to adsorb toxic chemicals Difficult to predict how particles will behave in the environment (dispersed/clumped ) Persistence : Longevity of particles in the environment and body are unknown ETHICAL DILEMMAS OF NANOTECHNOLOGY ● ● ● ● Playing God? Risk and Harm: patients and testing? Values: individual or community? Control over personal information? • Breeding of crops with higher micronutrients to detect pests & to control food processing • Nanoparticles to control soil, water and air contamination • Bionanotechnology helps in cleaner production of alternative and renewable energy sources • Graphene used as one-layer coating material • Nanofiber from zeolite for purifying methane gas in biodigesters • Chitosan fiber membrane from crustacean shells for heavy metal treatments in water • Nanobiosensors, nanosensors, biosensors, portable nanosensors, portable biosensors DANGERS OF NANOTECHNOLOGY Impacts of Nanotechnology to Health DNA Damage Lung Damage Cell Damage Immunosuppression Can cross the blood-brain barrier MODULE 10: BIOTECHNOLOGY (GMO AND GENE THERAPY) BIOTECHNOLOGY ● AIMS OF BIOTECHNOLOGY ● ● ● ● ● ● ● Nano-bomb Impacts of Nanotechnology to Environment (Nano-contaminants) Laundry: Ag NPs, metal oxide NPs Mining: fine metal oxide particles Combustion: soot/carbon, fly ash, fullerenes Medicine: Ag NPs, Au NPs Auto-traffic: Pa & Pt Nps Battery Waste, Fine Carbon Particles The use of microorganisms, cells, or cell components to make a product such as commercial production of foods, vaccines, antibiotics, and vitamins. Develop new precision tools and diagnostics Speed up breeding gains and efficiency Develop pest-resistant and disease-resistant crops Reduces inputs and production costs, increased profits Combat salinity, drought, and problems of agriculture Enhance the nutritional value of foods Increase crop varieties and choices HISTORY OF GMOs 1953 DNA discovered by Watson & Crick 1973 Boyer & Cohen modified an organism by combining genes from E.coli. 1982 • US Supreme Court allowed patenting of GMOs • FDA approved Humulin (insulin) from E.coli. 1993 FDA approved bovine somatotropin (bST) for increased milk production in cows 1994 FDA approved Flavr Savr tomato with longer shelf-life brii|6 1995 EPA approved Bt potatoes & corn, Roundup Ready Soybeans 1996 • Superweeds resistant to glyphosate were discovered. *glyphosate-herbicide for GMO crops • Dolly was “born” 1997 Mandatory labeling of GMO food 1998 GMO papaya in Hawaii resistant to Ringspot virus; produced Bacillus thuringiences toxin 1999 Over 100 million acres worldwide are planted with Genetically engineered seeds 2000 Golden rice was developed in the Philippines to address vit A deficiency; was thought to compromise 2003 Bt-toxin-resistant Helicoverpa zea was feasting on GMO cotton crops 2006 Yorkshire pigs were genetically modified to produce phytase in their saliva to digest phosphorous 2011 Researchers claimed that Bt toxin was found in blood of pregnant women 2013 Corn and poplars were genetically modified and used to produce biofuel 2014 • Patent on Roundup Ready line of genetically engineered seeds ended. • Monsanto was sued for chemical poisoning; was claimed to be caused by the pesticide Lasso (Roundup Ready line) ● ● traits or the production of desired biological products. Also known as transgenic organisms. Achieved through genetic engineering. BASIC STEPS IN GENETIC ENGINEERING 1. 2. 3. 4. DNA is cut by restriction enzymes. Recombinant DNA is produced. Gene cloning, many copies of the gene of interest are made each time the host cell reproduces. Cells undergo selection and then are screened. HISTORY OF GENE THERAPY 1972 Friedman & Roblin proposed that people with genetic disorders can be treated by replacing defective DNA with god DNA 1985 Anderson & Blaise showed that cells of patients with Adenosine deaminase (ADA) deficiency can be corrected 1990 First approved gene therapy on a 4-year old girl with ADA 1993 First somatic treatment that produced permanent genetic change was performed 2003 Gendicine; the first commercial gene therapy product for cancer treatment was approved in China ● 2016 Committee for Medicinal Products for Human Use of the European Medicines Agency endorsed gene therapy treatment called Strimvelis that was approved in 2018 ● THE PROCESS OF GENETIC ENGINEERING IN PAPAYA ● This is the first fruit tree ever genetically engineered (for resistance to a virus that kills papaya plants), conducted by Land Grant Universities (University of Hawaii and Cornell University) in the USA, and licensed to the Hawaii papaya industry for use and distribution. GENE THERAPY Gene therapy is the method of inserting gene or nucleic acid into cells as drug to treat genetic diseases. Stem cell therapy is the utilization of stem cells to treat or prevent disease or a condition. GENETICALLY MODIFIED ORGANISMS ● Genetically modified organism (GMO):organism whose DNA has been modified in the laboratory in order to favor the expression of desire physiological brii|7 TYPES GENE THERAPY ● ● Somatic Gene Therapy ○ Transfer of a gene to any cell of the body that does not produce sperm/eggs ○ The effects of gene therapy will not be passed onto the patient’s offspring Germline Gene Therapy ○ Transfer of a gene to any cell of the body that produce sperm/eggs ○ The effects of gene therapy will be passed onto the patient’s offspring BASIC STEPS IN GENE THERAPY 1. 2. 3. 4. 5. 6. Identification of the affected gene. Cloning of the required gene. Loading the vector with the required gene. Vector injected into the target cell. Vector delivers the gene into the nucleus of the target cell. Delivered gene performs its function. GENE THERAPY TECHNIQUES ● Gene augmentation therapy:if a required protein is absent or non-functional or defective, a functional gene is inserted to produce the required protein; cystic fibrosis ● Gene inhibition therapy: if protein products of s defective gene encourages the proliferation of disease-related cells, a new gene is inserted to either block the defective gene or its activity; cancer cell BIOTECHNOLOGY: PROGRESS, OPPOSITION AND RISK ASSESSMENT 1. 2. 3. 4. ● Genetic Contamination or Interbreeding ● Ecosystem Impacts Horizontal Transfer or Recombinant gene to other Microorganisms (HGT) ● Could cause unpredicted allergic reactions Biosafety ● Experiments might develop extremely infectious forms that could cause worldwide epidemics Destructive Use of Genetic Engineering Through Terrorism ● Moral and Ethical Issues Killing of specific cells- targets diseased cells by inserting “suicide” gene that produces toxic protein product killing the diseased cell; insertion of protein that will mark the cell for attact by immune system cells;cancer cell brii|8