This article has been accepted for publication in a future issue of this journal, but has not been fully edited. Content may change prior to final publication. Citation information: DOI 10.1109/TIM.2021.3102681, IEEE Transactions on Instrumentation and Measurement 1 High Precision Capacitive Sensors for Intravenous Fluid Monitoring in Hospitals Uzma Salmaz1, M A H Ahsan2, Tarikul Islam1*, Senior Member, IEEE Abstract— Automatic detection of the presence of intravenous fluids (IV) and measuring their drip rates are essential for intelligent health care applications. Conventionally, the drip rate is monitored manually by a gravimetric method which suffers from several drawbacks. Some smart commercial drip systems, which mostly work on the optical technique, have inaccuracy due to external light interference, temperature variation, and misalignment of a photodiode and photodetector. The main motivation of the present work is to investigate the usefulness of the capacitive sensors for the non-contact detection and measurement of flow rates of IV fluids. There is no previous work on IV drop detection by the capacitive sensors. This paper investigated three types of the capacitive sensors such as a crosscapacitive, a semi-cylindrical and a planar parallel plate to detect the presence of IV droplets in the fluid pipe nondestructively. The sensors are specially designed to fulfil the application needs, simulated and fabricated with inexpensive double side copper clad flexible PCB substrates. Experiments are conducted with the sensors for four IV fluids typically used in hospitals to determine their response parameters such as precision, drift, and drop rate when the droplet passes through the inner electric field of the sensors. There is an instantaneous change in the value of capacitance due to sudden change in the dielectric constant of partially filled air medium. The distinctive capacitance peak enables to count the droplets, and drip rate (0.4 m/s crosscapacitive) with highly precise (0.036%), and drift-free readings. All the sensors can be used for the target application but the cross capacitive sensor has single dimension accuracy. Index Terms— Capacitive sensors, IV fluids, droplet detection, response parameters comparisons. I. INTRODUCTION In medical health care, administering intravenous fluids (IV) is a cost-effective method that plays an essential role in maintaining fluids in the body of a patient in case of medical emergency [1]. Typical uses of intravenous injection are fluid replacement for rehydration, blood transfusion, maintaining the balance of electrolytes in the body, quick delivery of medicines that are either ineffective or take a long time when administered orally [2-4]. Due to increasing number of patients, a nursing staff has to attend to several patients to monitor their health conditions and maintaining fluid is one of the essential requirements. IV fluids with correct dose and correct rates should be administered to achieve the treatment goal. An overdose can cause fluid overload, elevation of blood pressure, electrolyte imbalance, and too fast an administration can led to pooling of fluid in the lungs, chances of kidney failure, diabetic emergency, and raised intracranial tension [6]. The rate of flow, type of fluid injected, fluid in the bag, and the number of units emptied are all critical to monitor [7-8]. Due to excess work This work is supported by fellowship from Council of Scientific and Industrial Research (CSIR), Human Resource Development Group, New Delhi, India with ACK. No.- 1431086/2K19/1 and FILE NO. -09/466(0246)/2020-EMR I (Corresponding author: Tarikul Islam) pressure of service providers, there is a possibility of wrong administration of fluids which lead to complication in patient’s conditions. Hence, there is a need to develop an online system that can monitor and alert medical attendants to take measures in correct time. The most common method is the gravimetric sensor which monitors the drop rate and the remaining drug volume. But it has some drawbacks, such as inaccurate calculation of drip rate and volume when the solution in the bottle is small. One of the most common methods is the optical technique using an IR sensor installed around a drip chamber [9]. As the flow rate deviates from its set value, an alarm rings to indicate the nurses [10]. The optical sensors are relatively expensive, prone to physical damage, and cause an error due to external interference of light, temperature variation, and misalignment of devices. In [11], an optical sensor is used to detect the presence of droplets and the capacitive sensor is used to detect the fluid level in the bag. It also consists of a microcontroller and GSM module for sending alert signals. A capacitive MEMS ultrasound sensor is used in [12] to measure the volumetric flow rate (0.05 ml/m) of IV fluids. A noninvasive microwave-reflectometry system is developed for automatic control and real-time monitoring of the flow and liquid level [13]. A flexible sensor integrated with cloud based bidirectional hetero-associative memory (BHAM) network warning tool is reported to detect infiltration and blood leakage [14]. In [15], a strain gauge load cell attached to the fluid bag, and in [16], a flexible MEMS piezoresistive sensors attached to the fluid tube is reported. However, the vibration generated weight measurement error is reported to be about ±10 gm for the 30-40 gm bag, which is quite large. Also, the resistive sensors being nonlinear devices require regular calibration and consumes significant power. Lee et al. have reported a simple and flexible coplanar capacitive sensor integrated with wireless communication module attached at the bottom of the bag to measure its level [17]. A RFID tag is attached to the IV bag to monitor status of fluid bag [18] but the device is not accurate, relatively expensive, and its implementation is not easy. Nowadays IoT enabled drip monitoring system is reported in the literature. The capacitive sensors are excellent devices for measuring different physical and chemical parameters. Essential features of the capacitive sensors are the possibility of non-contact measurement with high precision and reliability, low cost, high sensitivity, and low power consumption. Different types such as parallel plate, coaxial cylindrical, coaxial cross-capacitor, and coplanar interdigital capacitors can be used for sensing applications [19]. Parallel plate capacitive sensor is reported to measure liquid level IV bag but it has demerit of capacitance U. Salmaz and T.Islam are with the Department of Electrical Engineering, Jamia Millia Islamia (A Central University), New Delhi 110025, India. (e-mail: uzmasalmaz2015@gmail.com; tislam@jmi.ac.in). M A H Ahsan is with the department of physics, Jamia Millia Islamia (A Central University), New Delhi 110025, India. (e-mail: mahsan@jmi.ac.in). 0018-9456 (c) 2021 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_standards/publications/rights/index.html for more information. Authorized licensed use limited to: University of Glasgow. Downloaded on August 15,2021 at 16:58:43 UTC from IEEE Xplore. Restrictions apply. This article has been accepted for publication in a future issue of this journal, but has not been fully edited. Content may change prior to final publication. Citation information: DOI 10.1109/TIM.2021.3102681, IEEE Transactions on Instrumentation and Measurement 2 variation due to change in geometrical parameters. On the other hand, the cross-capacitor proposed by Thompson and Lampard consists of four concentration electrodes separated by small insulating gaps effectively can be used to precisely monitor the droplets in IV fluids because of its single-dimensional accuracy [20-21]. The main motivation of the present work is to investigate the usefulness of the capacitive sensors for the non-contact detection and measurement of flow rates of IV fluids. There is no previous work on IV drop detection by the capacitive sensors. Three capacitive sensors such as a cross-capacitive, a semi-cylindrical and a planar parallel plate are designed, simulated and fabricated with double side copper clad flexible PCB substrates. The design and fabrication of the sensors are simple, rugged, and inexpensive but adequate for the said purposes. Working principles are explained in section II, fabrication of the sensors and experimental methods are explained in section III and IV respectively. Experimental results are discussed in section V and the paper is concluded by section VI. II. WORKING PRINCIPLE OF THE SENSORS Three types of the capacitive sensors are used for the detection of IV fluid drops. One capacitor is a cylindrical coaxial crosscapacitor which is based on the Thompson and Lampard theorem. The other one is a semicircular parallel plate capacitor, and the third one is a circular planar parallel plate capacitor. The working of the individual capacitor is explained below. A. Parallel plate Capacitive sensor Fig. 1(a) shows the schematic diagram of the parallel plate capacitor. The structure consists of two circular parallel plates made on double side copper clad PCB. The positive electrode (high potential, H.P) is of 8 mm diameter which is guarded by a guard ring of inner diameter 8.6 mm and thickness 2.4 mm. The gap between the H.P electrode and the guard ring is 0.6 mm. The circular low potential (L.P) electrode of diameter 14 mm is separated from the H.P electrode by a distance of 9 mm. Each electrode is shielded by grounded metal shield. The electrodes are made on a rectangular PCB of dimension 40 mm × 18 mm by chemical etching. If the dielectric medium between the electrodes is free space, the capacitance of the sensor is given by A (1) Cp 0 d where 𝜀𝑜 is the permittivity of free space, A is the area of the circular plate (H.P), and d is the distance between the two plates. If the space of the capacitor is completely filled up by a dielectric medium r , the capacitance value is given by C P r .Now consider a small spherical liquid droplet of IV fluid of radius r (r<<d) and of dielectric constant r is placed at the centre of the capacitor as shown in Fig. 1 (a). The free space is now partially filled by a dielectric sphere of the droplet and if the sphere is not close to either of the electrode, then the capacitance value changes from its initial free space value C . The change in capacitance value due to partially filled condition is given by [23,31]. C 40 Metal r3 r 1 d 2 r 2 (2) Insulator Drop εr d= 9 mm (a) (b) Fig. 1. Circular parallel plate capacitor (a) schematic of the sensor with droplet (b) electric field distribution when a droplet is placed symmetrically at the center. This equation is derived for a planar parallel plate capacitor for a spherical drop but it is valid for the electrodes of any shape provided the electric field E due to excitation in the space is uniform in the region which is larger than the region occupied by the droplet at the position of the drop [23]. If the separation between the plates is 9 mm then for a water droplet of radius 2.3 mm, the theoretical change in capacitance determined using (2) is 17 fF. The structure in Fig. 1(a) is designed using ANSYS Maxwell 3D software. The electrostatic solution is used for analyzing the design of the structure. Triangular mesh is used to design the model due to its high accuracy and less simulation time. The gap between the electrodes is 9 mm, and diameter of the H.P and L.P electrodes are 8 mm and 14 mm respectively. The electrodes are made of copper, and an electrostatic shield is provided to eliminate the effect of external fields. The guard and electrostatic shields were grounded. Fig. 1 (b) shows the electric field distribution of the sensor. The capacitance values for air and with water droplet (with dielectric permittivity 81) are found to be 61.7 fF and 70.7 fF respectively. B. Semi-cylindrical capacitive sensor The structure of the semi-cylindrical sensor as shown in Fig. 2(a) consists of two semi-circular plates in the form of coaxial cylinder. The basic difference between the parallel plate capacitor and the semi-circular capacitor is that the gap between the electrodes in the former structure is fixed but in the semicircular structure it is varying. The electrodes are excited by potential of V and the total charge on an electrode is Q. The curved surface electrode can be represented by n number of distributed parallel plate capacitors with varying gaps between the electrodes. The electric field for the capacitor with air can be written as Q (3) E R1 h 0 where R1 is the radius of the electrode and h is the length of the electrode. The elemental separation between AB, is L = 2R1sinϴ + g, where ϴ is the angle between the radius and the horizontal plane of the curved surface and varies from 0 to π, so the change in elemental length along the surface dL 2R1 cosd . So, the potential difference can be written as V Q Q Q g 2R1 sin g 2 R1 cosd R1h 0 R1h 0 R1h 0 0 0018-9456 (c) 2021 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_standards/publications/rights/index.html for more information. Authorized licensed use limited to: University of Glasgow. Downloaded on August 15,2021 at 16:58:43 UTC from IEEE Xplore. Restrictions apply. This article has been accepted for publication in a future issue of this journal, but has not been fully edited. Content may change prior to final publication. Citation information: DOI 10.1109/TIM.2021.3102681, IEEE Transactions on Instrumentation and Measurement 3 capacitance value per unit length (C) for free space ( 0 ) is given The semi-circular capacitance with air is given by by [21]. R1 h 0 Q for 0 (4) V g 2 R1 sin In the present application, the electrodes are placed on an insulating hollow plastic tube of IV fluid of thickness t and dielectric constant p as shown in Fig. 2(b). If the thickness C 0 C sc t<<R1, then the capacitance value including the thin insulating tube will approximately be given by (4). When a tiny spherical liquid drop of IV fluid of radius r is placed at the centre of the capacitor shown in Fig. 2(a), it causes partial filling of air space by a dielectric liquid of permittivity r . This situation is similar to the situation as observed in the parallel plate capacitor. So, the capacitance value increases partially due to the liquid droplet with respect to the capacitor with air. Metal Insulator Axis V/2 Electrode Droplet A R θ θ A εr Drop B g gap g R Electrode Electrode gap Rsinθ B Rsinθ -V/2 (a) (b) (c) Fig. 2. Semi-cylindrical parallel plate capacitor (a) schematic of the sensor with droplet (b) actual sensor (c) electric field distribution when a droplet is placed symmetrically at the center. The change in capacitance is given by [23] C 4 0 r 3 r 1 2 R1 r 2 F/m (6) So, the capacitance value depends on the length of the electrode only. However, in the present sensor, the flexible electrodes are mounted on a hollow insulating tube which is an IV drip chamber made of polymer material (black color) as shown in Fig. 3(a). The outer radius of the chamber is R2 and its inner radius is R1. Therefore, the above equation is modified by including a parameter k due to the chamber placed within the electrodes of the capacitor. The value of k is constant and depends on the material of the insulating tube. The modified equation is given below ln 2 F/m (7) C k 0 where, 𝑘 = (1 + IV pipe ln 2 2 −1 𝜀𝑝 2𝜀𝑝 𝑙𝑛2 2 𝑅 3 3 𝑅 𝑅 {1+( 2 )4 }{1+( 1 )2 }2 𝑅3 𝑅3 𝑅 {1+(𝑅2 )2 } {1+( 1 )4 } 𝑅 ln[ ]) 𝜀𝑝 is the dielectric constant of the tube material. The above equation (7) is valid if the ratio of R2 1 and the dielectric R3 constant of the insulating tube is below 5. The detailed derivation of the cross-capacitor value for the structure shown in Fig. 3 with a hollow insulating tube of Teflon is reported in [22]. In the proposed work, the sensor was fabricated using double side copper clad Upilex 50S polyimide substrate procured from UBE, Japan. The thickness of the polyimide is 50 µm and the thickness of copper film is 12.5 µm. So, the values of R1, R2, and R3 are measured to be 7.2 mm, 8 mm, and 8.0125 mm respectively. Therefore, by substituting R1, R2, and R3 (5) In practical capacitors, the electrodes are shielded by the external metallic shield and there is a guard electrode on each end of the electrode. The electric field distribution of the capacitive sensor is shown in Fig.2. (c). The structure in Fig. 2(a) is simulated by ANSYS software with geometrical parameters: inner diameter 16 mm, length of electrode 20 mm, the guard length 4 mm. A conducting cylinder of diameter 16 mm and thickness 0.0125 mm is divided in two halves through the center with an insulating gap of 1 mm. The electrodes are excited by 1 V. The simulation procedure of the sensors is the same as described earlier, the only difference is the sensor structure. The simulated capacitance value with air was 894.72 fF. C. Cylindrical cross-capacitor Fig. 3 (a) shows the schematic diagram of the cross-capacitor having four electrodes A, B, C, and D separated by small gaps and enclosed in a conducting shield. R2 and R3 are the inner and outer radius of the electrodes. CAC and CBD are the crosscapacitances across the opposite faces of the electrodes without insulating tube. If the capacitances C AC CBD C , then R2 1 , R1 8.0125 0.8985and 𝜀𝑝 = 2.1 for polypropylene, R3 R3 7.2000 the value of k is found to be 1.01. The necessary conditions for the modified expression are valid. Now if a spherical IV fluid drop of radius r is placed at the centre as shown in Fig. 3(a), the space is partially filled with dielectric medium of permittivity r . This situation is again similar to the condition as mentioned for other two capacitors. The shape of the electrode of the cross capacitor is cylindrical with separation between two crosselectrodes d = 2R1 is much greater than the radius of the drop r. The change in capacitance can be given by (5). From (6), the capacitance value for a 2 cm long electrode is 39.07 fF. On including the k value because of the presence of the drip chamber, the value of capacitance becomes 39.46 fF. So, k will have a small effect on the overall capacitance value, provided its thickness is small. However, in practice two of the diagonally opposite electrodes are connected to the ground terminal and the capacitance between the other pair of electrode CBD is measured. The cross-capacitor then can be equivalently represented by a pi network shown in Fig. 3(b). according to the Thompson and Lampard (TL) theorem, the 0018-9456 (c) 2021 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_standards/publications/rights/index.html for more information. Authorized licensed use limited to: University of Glasgow. Downloaded on August 15,2021 at 16:58:43 UTC from IEEE Xplore. Restrictions apply. This article has been accepted for publication in a future issue of this journal, but has not been fully edited. Content may change prior to final publication. Citation information: DOI 10.1109/TIM.2021.3102681, IEEE Transactions on Instrumentation and Measurement 4 Insulator A B R2 R1 εr Drop D CBD R3 A D . IV pipe B C C (a) (b) Fig.5. Photograph of the cross capacitive sensor (a) front side, (b) backside side. Electrode gap (a) (b) (c) Fig. 3. Cylindrical cross-capacitor (a) schematic of the sensor with droplet (b) equivalent circuit (c) electric field distribution when a droplet is placed at the center. Recently, the cross-capacitor is used in different sensing applications including quantification and identification of liquid droplets of various sizes [24], precise measurement of humidity [25], dielectric constants of liquid samples [26], and metal debris detection in lubricating oil [27]. The cross sensor is designed using finite element software ANSYS Maxwell 3D software with the geometrical parameters R1 = 7.2 mm, R2 = 8 mm, R3 = 8.0125 mm, the length of the electrode 20 mm and the gap between the electrodes 1 mm. Fig. 3 (c) shows the electric field distribution of the cross capacitive sensor. The cylinder is made of copper. Voltage excitation was applied to the B & D electrodes (±1V), and the electrodes A & C including guard electrodes and outer metal shield are grounded. The capacitance values between B and D electrodes for air and water droplet (with dielectric permittivity 81) are found to be 39.4 fF and 44.2 fF respectively. The value with air is approximately equal to the theoretically value. III. FABRICATION OF THE CAPACITIVE SENSORS A. Cross and cylindrical capacitive sensor The cross-capacitive sensor shown in Fig. 4(a) was fabricated on flexible double-sided copper-cladded polyamide substrate (Upilex, Japan) of size 50 mm × 24 mm. The polyamide sheet was thoroughly cleansed with acetone and DI water and then ultrasonicated for 15 m at 60 ℃. The mask of each sensor was designed using AutoCAD software, and it was then screen printed on the polyamide substrate. The size of the electrode was 8 mm θ 20 mm and the size of the gap was 1 mm. Two guard electrodes of width 8 mm were made on each side of the main electrodes with a gap of 1 mm. The screen-printed substrates were then immersed in ferric chloride solution to form the structures shown in the Fig.4 (a). The metal film on the opposite side of the substrate was masked to avoid chemical etching. The structure was then cleansed thoroughly. The two edges of the polyamide sheet were connected by wrapping it on the IV plastic chamber of diameter 16 mm. Fig. 5 shows the image of the sensor. The sensor's terminals, including the guard and shield electrodes, were adequately connected to the AD7150 board to measure capacitance values. A schematic of the semicylindrical parallel plate sensor is shown in Fig. 4 (b). The structure was having two identical electrodes made on the flexible PCB of size 20 mm × 24 mm. The gap between the electrodes was 1 mm. The structure was then wrapped on the outer wall of the IV chamber of diameter 16 mm with main electrodes on the inner side to form the semicircular capacitor. Two electrodes A and B were connected to the evaluation board to measure the capacitance and the metal shield and guard electrodes were connected to the ground terminal of the board. B. Circular Parallel plate sensor To fabricate a circular parallel plate capacitive sensor shown in Fig. 6(a) firstly the double-sided copper-cladded PCB was cut in the dimension of 20 × 40 mm. The PCB was cleaned with acetone and DI water and ultrasonicated for 15 m at 60 ℃. The circular mask was made using AUTOCAD software with dimensions and structure mentioned in the Fig. 6(b). The mask was printed on the PCB. The electrodes are etched out using ferric chloride solution. The sensor was then cleaned properly. The backside of the PCB was kept intact for the shield. The guard ring was provided to the H.P to reduce the fringing field effect. Two parallel plates of the capacitor were separated with by a gap of 9 mm. Terminals of the H.P and L.P including the guard and metal shield were connected to the evaluation board AD7150 for the measurement of the capacitance value. The dispensing unit was placed such that liquid drops passes through the middle of the air gap between the electrodes. 20 mm 18 mm 18 mm 8 mm Front side of PCB Front side of PCB 40 mm Metal Back side of PCB Back side of PCB (b) (a) (c) Fig. 6. Parallel plate sensor for drip monitoring (a) experimental setup (b) schematic of the circular capacitor (c) photo of the sensor. IV. EXPERIMENTAL SETUP (a) (b) Fig. 4. Schematic of the fabricated sensor (a) the cross capacitive sensor. (b) the semi-cylindrical capacitive sensor. The experimental setup consists of a tall stand with clamps to hold the IV-fluid bag. The drip chamber of the IV tube is connected to the bag. Then, all four electrodes are connected to 0018-9456 (c) 2021 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_standards/publications/rights/index.html for more information. Authorized licensed use limited to: University of Glasgow. Downloaded on August 15,2021 at 16:58:43 UTC from IEEE Xplore. Restrictions apply. This article has been accepted for publication in a future issue of this journal, but has not been fully edited. Content may change prior to final publication. Citation information: DOI 10.1109/TIM.2021.3102681, IEEE Transactions on Instrumentation and Measurement 5 the AD7150 board, as shown in Fig. 7 (a, b). Two diagonally opposite electrodes were connected to the ground terminal. The other two electrodes were connected to the Cx pin and EXC pin respectively. An AD7150 evaluation board (EVALAD7150EBZ), is a capacitance-to-digital converter (CDC) having two channels to connect two sensors simultaneously [29]. Experiment was conducted with each sensor separately, so one port was connected to the PC for data acquisition and the other port was disabled. With the proper settings of the port, data was acquired using data acquisition software provided by the manufacturer. The board has different capacitance measurement ranges. Since the capacitance value of each sensor was small and the change in capacitance was of few tens of fF, the minimum range of 0-0.5 pF and highest resolution 1 fF in continuous adaptive mode was selected. The conversion time for each port is 10 ms. The average of about 4 to 5 data points can be acquired using the AD7150 evaluation board in 50 ms. The interfacing circuit and the photograph of the setup are shown in Fig. 7(a), and Fig. 7(b) respectively. card and stored in the datasheet. The capacitance value from the digital data (Data) was determined using the given expression [29] Data 12288 (8) C CR 40944 where CR is the input capacitance range (0-0.5 pF). The capacitance values corresponding to the droplets was acquired for 10 s for cross and semi-cylindrical capacitive sensors and 1500 ms for parallel plate sensor. The drop rate was kept different for each sensor to ensure rapidness of droplet detection. Variation of the capacitance values repeated for several identical drops at different rates are shown in Fig. 8, 9 and 10 for cross, semi-cylindrical and parallel plate capacitive sensors respectively. Fig. 8. Capacitive peaks with cross capacitive sensor for NS IV fluid. (a) IV bag Ad7150 Board Connected to system Sensor AD7150 board IV tube Flow regulator It is observed that initially, the capacitance value is at reference base value without fluid. The base value of each sensor is different due to different expressions and geometrical values. The moment the droplet passes through the inner chamber, the capacitance value rises sharply, and then returns to the base when the droplet goes out of the chamber. Almost a similar capacitance peak is observed for each droplet. Beaker (b) Fig. 7. (a) Interfacing circuit. (b) photograph of the experimental setup. V. RESULTS AND DISCUSSION Experiments were conducted to determine the following parameters A. The variation of capacitance value with IV fluid droplets B. Repeatability of the sensor output C. The speed of the droplet. D. Drift in sensor output E. Comparative study of the sensors . Fig.9. The capacitance peaks with a semicylindrical capacitive sensor for NS IV fluid droplets. A. The variation of capacitance with droplets i. Capacitive response of the sensors for NS IV fluid Initially, the experiment was conducted with the cross capacitive sensor with NS (0.9% w/v Sodium Chloride in 100 ml of water) IV fluid sample at controlled room temperature of 25°C. The droplets of NS fluid were passed through the tube and chamber. The digital data corresponding to the actual capacitance values was acquired through the data acquisition Fig.10. The capacitance peaks with circular parallel plate sensor for NS IV fluid droplets. 0018-9456 (c) 2021 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_standards/publications/rights/index.html for more information. Authorized licensed use limited to: University of Glasgow. Downloaded on August 15,2021 at 16:58:43 UTC from IEEE Xplore. Restrictions apply. This article has been accepted for publication in a future issue of this journal, but has not been fully edited. Content may change prior to final publication. Citation information: DOI 10.1109/TIM.2021.3102681, IEEE Transactions on Instrumentation and Measurement 6 Capacitance peaks for each droplet are visible and repeatable. It was expected that peaks for the identical droplet for each sensor should be exactly identical but there is a minor deviation. This may due to the facts that for cross and semi-circular capacitors experiments were conducted by mounting the sensors on the outer wall of the IV fluid tube. The wall causes series capacitance effect which reduces the overall sensitivity of the sensors. Also, leads have fluctuating contribution to the small value capacitance of the sensor. But for parallel plate, droplets were directly allowed to pass through the inner space of the chamber so the series capacitance effect is neglected except the lead capacitance effect. However, one intriguing phenomenon is observed both in Fig.8 and 9. When the drop enters the tube, the capacitance value goes below the base value and then rises to the peak value. All the three capacitors have guard electrodes which were maintained at ground potential. The electric field lines go from the positive electrode to the negative electrode including the guard electrode. Before falling, the drop is attached to the bulk liquid, and elongates in the vicinity of the guard electrode. Also, the shape of the dispensed droplet fluctuates and passes through the sensor with certain speed. Even long jets can occur, depending on the ejection characteristics of the liquid. The droplet then bypasses some electric field to the ground causing less field to the negative electrode. So, the accumulation of charges to the negative electrode is less causing reduction in capacitance value from the base value. But when the droplet detaches from bulk liquid and passes away through the guard electrode, more electric field reaches to the negative electrode causing increase in capacitance value and it becomes maximum at the middle of the electrodes. By the time droplet also becomes spherical. This effect may be more if the nozzle of the drop is close to the guard electrode. In case of parallel plate capacitor, guard electrode is quite away from the nozzle and there is no insulating layer between the droplet and the electrodes, so this effect is less pronounced as shown in Fig. 10. However, we need to investigate this negative peak phenomenon in more detail considering all these parameters [30,31]. ii. Capacitances change with different Intravenous fluids The experiments were conducted with three others commonly used IV fluids such as DNS (Sodium Chloride 0.9% w/v and Dextrose 5% w/v in 100 ml of water, B. Braun), 5D (5% w/v Dextrose in 100 ml of water, B. Braun), and RL (sodium chloride 6 g/L, sodium lactate 3.1 g/L, potassium chloride 0.3 g/L, and calcium chloride 0.2 g/L, B. Braun). The variation of the cross-capacitance of all the four different IV fluids is shown in Fig. 11. The fabricated sensor can detect the presence of intravenous fluid in the IV bag, and it is also capable of delivering the change in capacitance value for different IV fluids. The average peak heights of drops are 5.65 fF, 6.39 fF, 5.29 fF, and 5.68 fF for NS, DNS, 5D, and RL intravenous fluids respectively. However, the difference is minor because of the significantly less concentration of salts present. The average base value of the sensor is 55.15fF. The averaged capacitance value for six consecutive droplets from each sample are shown in Table I. TABLE I PEAK CAPACITANCE VALUES OF DIFFERENT IV FLUIDS Type of fluid NS DNS 5D RL Average peak capacitance value 60.80 61.54 60.44 60.83 B. Repeatability Repeatability is the property of a measuring instrument that gives the same result for consecutive measurements. But the experiments are performed with the same input, environmental conditions, apparatus used, and experimenter. Data of each sensor for the NS intravenous fluid sample is analyzed to test the repeatability of the sensor output. The repeatability is given by [24] % C1 Cm 2 C2 Cm C3 Cm .................. Cn Cm 2 2 2 n 1 Cm 2 100 (9) Where ℜ is the repeatability index, 𝐶𝑚 is the mean capacitance, 𝐶1 𝐶2 𝐶3 …….𝐶𝑛 are obtained capacitance values at the peak, and n is the number of readings. TABLE II REPEATABILITY OF THE SENSOR OUTPUT FOR NS IV FLUID Drop numbers 1 2 3 4 5 6 Repeatabi lity (%) Cross capacitive (fF) 60.80 60.93 61.03 60.77 60.83 60.91 0.036 Semicylindrical (fF) 960.14 959.75 960.14 960.23 960.14 959.31 0.008 Circular parallel (fF) 96.35 96.32 95.98 95.51 95.13 95.89 0.11 The repeatability of the sensor as calculated using (9) is approximately 0.036%, 0.015%, 0.026%, and 0.055% for NS, DNS, 5D, and RL IV fluids, respectively. The repeatability for all three sensors is shown in Table II. Hence, the sensors' readings are repeatable. The difference in the highest and lowest peak value for the cross capacitive sensor is 0.26 fF, for the semicylindrical capacitive sensor is 0.92 fF, and for the parallel plate sensor 1.22 fF. Fig.11. Sensor response with other IV fluids. 0018-9456 (c) 2021 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_standards/publications/rights/index.html for more information. Authorized licensed use limited to: University of Glasgow. Downloaded on August 15,2021 at 16:58:43 UTC from IEEE Xplore. Restrictions apply. This article has been accepted for publication in a future issue of this journal, but has not been fully edited. Content may change prior to final publication. Citation information: DOI 10.1109/TIM.2021.3102681, IEEE Transactions on Instrumentation and Measurement 7 C. Drop speed E. Comparative study of the sensors Fig. 12. A single peak of NS fluid of the cross capacitive sensor. Drop speed is the speed with which the drop passes through the sensor. The length of the electrode was 20mm. Fig. 12 shows the capacitance vs time plot of a drop for the cross capacitive sensor. The corresponding time for the droplet to enter and leaves the sensor is 0.98 s and 1.03 s, respectively. Hence the drop takes 50 ms to travel between the electrodes of the sensor after detaching from bulk solution. Therefore, droplet fall freely at the speed of 0.4 m/s. Experiments were also conducted with variation of the speed of the droplets keeping the size of the droplet same. The speed was varied in the range of 0.148 to 4 × 10-3 m/s but the capacitance value varies from its mean value (60.63) by ±0.19 fF. So, the capacitance change remains almost same. D. Drift Drift is the gradual decrease in performance of the sensor over a period of time. The experiment was conducted with the crosssensor with NS IV droplet for a month to observe the drift in the output. The average peak capacitance and average nominal capacitance values for the month of February are shown in Table III. Results show that the capacitance values are quite stable for a month. The maximum deviation from the mean value is 0.96% The value of capacitance for cross capacitive sensor only depends upon the length and does not depend on radius or any other dimension. It is also easy to install on an IV pipe. The semi-cylindrical electrodes are also easy to install on the pipes but depends on geometrical parameters. It depends on the inner radius of the chamber, length of the electrode, the gap between the electrode, and angle between the radius and horizontal plane of the curved surface. The parallel plate sensor is not easy to install on curved surfaces. The proposed sensors are highly repeatable, precise, and drift-free. The capacitive sensors are advantageous over other types of sensors. It has a simple structure, easy fabrication, unsophisticated in design, installation, and maintenance. The calculated, simulated, and experimental values with the free space with typical dimensions of the sensors are given in Table IV. Table V consists of the literature survey for the proposed work. Theoretical values for cross and semi-cylindrical capacitive sensor are more than simulated values because the k factor is included in the formula for the presence of IV chamber between the electrodes. The experimental values for all the sensors are larger than the simulated and calculated values because of the presence of fringing capacitance and lead wire capacitance. The sensitivities of the sensors to NS IV fluid are determined from the response curve and are shown in Table VI. The table shows that the parallel plate sensor has the highest sensitivity. This is because the droplets are directly allowed to pass through the electrodes and the capacitance value does not have series capacitance effect due to plastic wall of the chamber. The repeatability index (ℜ) shows the extent to which the data can exist around the mean. A value less than 1 indicate good repeatability of data. The repeatability index of the sensor is the measure of its precision. Hence, we can say that the proposed sensors are highly precise. TABLE IV AIR CAPACITANE VALUES OF THE SENSORS Type of sensor Theoretical value (fF) Simulated value fF) Experimental value (fF) Cross capacitive Semi-cylindrical capacitive Parallel plate 39.46 912.4 39.4 894.7 55.2 947.7 49.5 61.7 70.8 TABLE III PEAK AND NOMINAL CAPACITANCE VALUE OVER A MONTH Days 1 February 8 February 15 February 23 February 29 February Average peak capacitance (fF) 60.80 60.77 60.28 59.82 60.33 Average nominal capacitance (fF) 55.40 55.42 54.61 54.28 55.13 TABLE V LITERATURE SURVEY OF THE PROPOSED WORK Reference Structure Expression Contact Fabrication Proposed work Cross Capacitive Non-contact Easy Semicylindrical Parallel plate simple and exact complex simple Non-contact Contact Easy Easy Piezoresistive Optical complex complex Non-contact Non-contact complex complex [7], [12], [15] [9], [11], [18] Repeatabili ty ℜ (%) 0.036 0.008 0.11 - Drift Drift free - Demerits The low base capacitance value Complicated theoretical relation Not easy to install Temperature error, consumes more power and requires calibration relatively expensive, prone to physical damage, and error due to external interference of light, temperature variation, and misalignment of devices 0018-9456 (c) 2021 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_standards/publications/rights/index.html for more information. Authorized licensed use limited to: University of Glasgow. Downloaded on August 15,2021 at 16:58:43 UTC from IEEE Xplore. Restrictions apply. This article has been accepted for publication in a future issue of this journal, but has not been fully edited. Content may change prior to final publication. Citation information: DOI 10.1109/TIM.2021.3102681, IEEE Transactions on Instrumentation and Measurement 8 [13] Microwave sensing complex Non-contact Simple - - [14], [17] Coplanar complex Contact simple - - TABLE VI COMPARISON OF PROPOSED CAPACITIVE SENSORS Sensor Cross Semicylindrical Parallel plate Peak value (fF) C C0 Drift Repeat. ℜ (%) 5.65 12.25 0.102 0.013 free - 0.036 0.008 Drop speed (m/s) 0.4 0.4 25.09 0.354 - 0.11 0.4 VI. CONCLUSION This paper presents the design, fabrication, and experimental validation of a drip rate monitoring system using capacitive sensors. Three sensors, such as a cylindrical cross capacitor, semicylindrical capacitor, and circular parallel plates, are fabricated on copper-cladded PCB. Experiments are conducted with four IV fluids which are typically used in health care applications. The sensors have shown a minimal variation for different types of IV fluids because of the nearly identical concentration of salt present. The sensors are used to count the drops (number of peaks) and measure the drip-rate. All the sensors are effective to monitor the drip rates (0.4 m/s) without any contact to the medium and the outputs are precise and driftfree. The fabrication of the sensors is easy and inexpensive but installation, precision and accuracy of the cylindrical cross capacitor are better than semi-cylindrical and planar parallel plate capacitors. Hence, cross capacitive sensor is best suited for this application. Acknowledgement: Experiments were conducted in the Sensors and Instrumentation lab, Jamia Millia Islamia, New Delhi with the facilities created from sponsored projects. REFERENCES: [1] G. I. Voss and R. D. Butterfield, "Parenteral Infusion Devices," in The Biomedical Engineering Handbook, 2nd ed., vol. 1, J. D. Bronzino, Ed. Boca Raton, Florida: CRC Press LLC, 2000. [2] Administration, Infusion pumps, US Food & Drug, August 22, 2018. Accessed on: April 23, 2021. [Online]. Available: https://www.fda.gov/medicaldevices/productsandmedicalprocedures/generalh ospitaldevicesandsupplies/infusionpumps/ [3] S. Thurman, M. Sullivan, M. A. Williams, and A. Gaffney, "Intravenous medication safety systems help prevent harm and career-ending mistakes," J Nurs Adm, Vol. 34, December 2004. [4] L. J. Murdoch, and V. L. 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Citation information: DOI 10.1109/TIM.2021.3102681, IEEE Transactions on Instrumentation and Measurement TIM-21-01415R2 9 [28] Analog Devices, "AD 7150 Eval Board," Datasheet, http://www.analog.com/media/ [29] Andreas Ernst, Klaus Mutschler, Laurent Tanguy, Nils Paust, Roland Zengerle, and Peter Koltay, “Numerical Investigations on Electric Field Characteristics with Respect to Capacitive Detection of Free-Flying Droplets,” Sensors, 12, 10550-10565, 2012. [30] A. Ernst, Lin Ju, B. Vondenbusch, Roland Zengerle, Peter Koltay, Noncontact Determination of velocity and volume of nanoliter droplets on the fly, IEEE Sensors J., Vol. 11, No. 8, pp 1736-1742, August 2011. [31] [Online]. Available: http://www.ube.com/upilex/en/ Uzma Salmaz received the Bachelor and Master degree in Electrical Engineering from Jamia Millia Islamia (JMI) University, New Delhi, in 2014 and 2017 respectively, where she is currently working toward the Ph.D. degree. Her research interests include development of sensors, and electronic instrumentation. M A H Ahsan completed his MSc (Physics) from IIT Kanpur and received his PhD (Physics) in 1998 from IIT Bombay, Mumbai. He subsequently carried out post-Doctoral research work at Raman Research Institute, Bangalore (Bengaluru) from 1998 to 2000 and later at IISc, Bangalore (Bengaluru) from 2000 to 2002. He was a Visiting Scientist at SISSA, Italy from September 2004 to January 2005 and later at MartinLuther University, Germany from August 2008 to August 2009. He is recipient of DAAD Research and Study Fellowship. Since 2002, he has been teaching at the Department of Physics, Jamia Millia Islamia, New Delhi where he is currently a (Full) Professor. He has taught a variety of courses including Electromagnetic Theory, Advanced Classical Electrodynamics and Quantum Field Theory at the Undergraduate, Postgraduate and Pre-PhD level. He has guided seven PhD theses. His broad area of research is Condensed Matter Physics. Tarikul Islam (M’16-SM’20) was born in Murshidabad, West Bengal, India. He received the M.Sc. Engg. Degree in instrumentation and control system from A. M. U. Aligarh, U.P. in 1997 and the Ph. D (Engg..) degree from Jadavpur University, Kolkata, India, in 2007. From 1997 to 2006, he was Assistant Professor and from 2006 to 2012, he was Associate Professor with the Electrical Engg. Deptt. Jamia Millia Islamia (A Central University), New Delhi. Since, 2012, he is working as professor with same university.He has over 20 years of teaching and research experiences. He has authored/coauthored 5 book chapters, one edited book, filed two Indian patents and published more than 155 papers in peer reviewed journals and conferences. He received research grants from government agencies like DST, DRDO, MHRD, CPRI, DAE of more than 260,000 (US$). His research interests include sensors and sensing technologies, electronic instrumentation. He is a life member of IETE (India), ISTE (India) and senior member of IEEE. He is a topical editor, IEEE Sensors journal and IEEE Trans. Instrum. & Meas. He is a co-editor of a specialissue of an International Journal of Electronics. 0018-9456 (c) 2021 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. See http://www.ieee.org/publications_standards/publications/rights/index.html for more information. Authorized licensed use limited to: University of Glasgow. Downloaded on August 15,2021 at 16:58:43 UTC from IEEE Xplore. Restrictions apply.