Government College of Pharmacy, Karad
Pharmaceutical Chemistry [2020-21]
Title : SHIVAJI UNIVERSITY, KOLHAPUR THEORY EXAMINATION, APRIL-MAY 2021, F.Y. M. Pharm.
(Pharmaceutical Chemistry) (Sem II), Advanced Spectral Analysis (70682)
Subject : Advanced Spectral Analysis - Theory
Faculty : Manoj Shrawan Charde
Year : First Year - Second Semester
Date : Mon 25 Oct, 2021
Marks : 50
Duration : 60 Minutes
1 ] Question : Multiple grating system is used in Raman spectroscopy [Single Correct] [2 Marks]
1 ) To isolate the selected wavelength from polychromatic source
2 ) It has multiplex advantage
3 ) To disperse the light emitted by source
4 ) To separate weak Raman lines from other radiations
Explanation :
Bloom's Level: Apply
2 ] Question : Loss of water of crystallization will be represented in DSC plot as [Single Correct] [2 Marks]
1 ) Downward slope
2 ) Upward slope
3 ) Downward peak
4 ) Upward peak
Explanation :
Bloom's Level: Understand
3 ] Question : Base value for the given compound is [Single Correct] [2 Marks]
1 ) 230 nm
2 ) 250 nm
3 ) 246nm
4 ) 217 nm
Explanation :
Bloom's Level: Evaluate
4 ] Question : Metastable ions are easily recognized in the mass spectrum due to its characteristics [Single
Correct] [2 Marks]
1 ) they show broad peaks than normal ion
2 ) they show relatively more abundance
3 ) stable peaks
4 ) uniform peaks
Explanation :
Bloom's Level: Apply
5 ] Question : Which of the following is used to confirm the presence of HIV infection in individuals who are
antibody-positive by ELISA? [Single Correct] [2 Marks]
1 ) Western blot
2 ) Hemagglutination
3 ) Ouchterlony test
4 ) Complement fixation
Explanation :
Bloom's Level: Remember, Apply
6 ] Question : In the application of DTA and DSC which of the following parameters is measured for the
glasses? [Single Correct] [2 Marks]
1 ) Concentration of the glass
2 ) Solubility of the glass
3 ) Cooling temperature
4 ) Transition temperature
Explanation :
Bloom's Level: Remember, Apply
7 ] Question : Which of the following proton has more chemical shift in NMR [Single Correct] [2 Marks]
1 ) Alcohols
2 ) Carboxylic acid
3 ) Ketone
4 ) Vinylic
Explanation :
Bloom's Level: Remember, Apply
8 ] Question : The approximate value of methyl proton in NMR is [Single Correct] [2 Marks]
1 ) 1.5
2 ) 0.9
3 ) 2.1
4 ) 4.5
Explanation :
Bloom's Level: Understand, Evaluate
9 ] Question : How many NMR signals appear in the 1H NMR spectrum of (CH3)4C? [Single Correct] [2 Marks]
1) 1
2)2
3)3
4)4
Explanation :
Bloom's Level: Remember, Apply
10 ] Question : DSC curve is plot of [Single Correct] [2 Marks]
1 ) Differential temperature vs temperature of furnace
2 ) Differential temperature vs time
3 ) Differential temperature vs temperature of reference
4 ) Heat flow against temperature
Explanation :
Bloom's Level: Apply
11 ] Question : Number of signals for Benzaldehyde in NMR are [Single Correct] [2 Marks]
1)1
2)2
3) 3
4)4
Explanation :
Bloom's Level: Understand
12 ] Question : McLafferty Rearrangement is shown by ----- [Single Correct] [2 Marks]
1 ) aldehyde
2 ) ketone
3 ) alcohol
4 ) all of above
Explanation :
Bloom's Level: Apply
13 ] Question : Which of the following statements regarding NMR is wrong? [Single Correct] [2 Marks]
1 ) NMR signals towards the left of spectral chart correspond to larger chemical shifts
2 ) Chemical shifts are larger when the frequencies of the radiation which induces the nuclear transitions are higher.
3 ) Chemical shifts are larger when shielding effects are greater
4 ) A hydrogen signal splits into n + 1 rule peaks by spin-spin coupling when the number of equivalent hydrogen
atoms on adjacent atom is n, and no other neighboring atoms are involved
Explanation :
Bloom's Level: Remember, Analyze
14 ] Question : 2-Heptanone undergoes McLafferty rearrangement with release of _____ [Single Correct] [2
Marks]
1 ) ethane
2 ) propene
3 ) isobutene
4 ) 1-butene
Explanation :
Bloom's Level: Apply
15 ] Question : Molecular ion peak is also known as _____ [Single Correct] [2 Marks]
1 ) Daughter Peak
2 ) Metastable Peak
3 ) Parent ion
4 ) Base Peak
Explanation :
Bloom's Level: Remember, Evaluate
16 ] Question : The number of peaks given by the proton NMR spectrum of 2- methyl -1-pentene are [Single
Correct] [2 Marks]
1)4
2) 5
3)6
4)3
Explanation :
Bloom's Level: Evaluate
17 ] Question : The number of peaks by diethyl ether in NMR spectrum are as--------------- [Single Correct] [2
Marks]
1)4
2) 2
3)1
4)5
Explanation :
Bloom's Level: Understand
18 ] Question : In Mass Spectroscopy, a cation with 100% abundance is known as [Single Correct] [2 Marks]
1 ) Parent ion
2 ) Base peak
3 ) Fragment ion
4 ) Radical cation
Explanation :
Bloom's Level: Understand, Analyze
19 ] Question : DTA can be used for which of the following process [Single Correct] [2 Marks]
1 ) Line positions of the crystals
2 ) Mechanical properties of the crystals
3 ) Phase Diagrams
4 ) Catalytic properties of enzymes
Explanation :
Bloom's Level: Remember, Apply
20 ] Question : Which is working principle of ELISA? [Single Correct] [2 Marks]
1 ) Ag-Ab neturalization
2 ) Ag-Ab complex
3 ) (A) and (B)
4 ) None of the above
Explanation :
Bloom's Level: Remember, Analyze
21 ] Question : Tropylium ion shows peak at m/e [Single Correct] [2 Marks]
1 ) 91
2 ) 77
3 ) 90
4 ) 89
Explanation :
Bloom's Level: Understand, Evaluate
22 ] Question : Bioassays are carried out to --------. [Single Correct] [2 Marks]
1 ) Measure the pharmacological activity of a drug
2 ) Avoid clinical trials for new drugs
3 ) Detect the impurity in given drug
4 ) Screen for phramacogenetic influences of new drugs
Explanation :
Bloom's Level: Evaluate
23 ] Question : Nitriles show absorbance at wavelength_______. [Single Correct] [2 Marks]
1 ) 2250 cm-1
2 ) 2950 cm-1
3 ) 2800 cm-1
4 ) 1800 cm-1
Explanation :
Bloom's Level: Understand, Evaluate
24 ] Question : How many peaks this compound may give in NMR spectroscopy? C6H5-CH2-CH2-CH3
[Single Correct] [2 Marks]
1) 4
2)3
3)2
4)1
Explanation :
Bloom's Level: Remember, Apply
25 ] Question : Finger print region is characteristic of the organic compound. Identify it. [Single Correct] [2
Marks]
1 ) 3300-1400 cm-1
2 ) 3000-1200 cm-1
3 ) 1400-666 cm-1
4 ) 2800-1000 cm-1
Explanation :
Bloom's Level: Apply, Create
Marks distribution as per Bloom's level
Bloom's
Level
Linked Question
Count
Marks
Percentage
Create
1
2
4.00
Evaluate
7
14
28.00
Analyze
3
6
12.00
Apply
12
24
48.00
Understand
7
14
28.00
Remember
9
18
36.00
NOTE : Percentage for each Bloom's level is calculated using following formula
Percentage = ( Marks per Bloom's level / Total marks of all questions ) * 100