SURIGAO EDUCATION CENTER College of Allied Medical Sciences Nursing Department Km 2 Brgy. Luna, Surigao City CASE STUDY OF CACHEXIA/ SQUAMOUS CELL CARCINOMA, TONGUE PRESENTED BY: GROUP 1 INTRODUCTION Squamous cell carcinoma of the oral tongue (SCCOT) is one of the most prevalent tumors of the tongue and neck region. Squamous cells are the flat, skin like cells that cover the lining of the mouth, nose, larynx, thyroid and throat. Squamous cell carcinoma is the name for a cancer that starts in these cells. Cancer is when abnormal cells start to divide and grow in an uncontrolled way. More than 90% of malignant tumors diagnosed in the oral cavity are Oral Squamous Cell Carcinomas (OSCC) whose preferred location is the tongue. Classically, this disease has affected men preferentially, although recent studies suggest that trends are changing and the proportion of women with OSCC is increasing. In addition, the prevalence of oral cancer is also determined by some risk factors as alcohol consumption and tobacco. Currently, the Tumor, Node, Metastasis (TNM) classification is employed to defined tumor stage and based on this guide specific treatments are established. However, 5-year-survival does not exceed 50% of cases. The objective of this study is to determine whether a histological risk pattern indicative of higher recurrence might be present in T1-T2 tumors located in the anterior two thirds of the tongue. (Yamini Ranchod, Ph.D., M.S. — By Erica Hersh — Updated on March 30, 2019) INTRODUCTION Patient C, a 73-year-old man from Kasilak, Poblacion Tubod, Surigao del Norte was admitted on May 16, 2023 at 12:05 p.m with a chief complaint of body malaise and loss of appetite that he has been suffering that noted for five months due to inability to eat solids and pain in swallowing, and was later diagnosed with Squamous cell carcinoma of the tongue at Surigao Medical Center under the supervision of Dr. Victor Dumagas. We chose this case because we want to know why men are most likely to suffer from squamous cell carcinoma of the tongue and we are curious about the disease process itself. We want to educate them on how to prevent ourselves not to have this oral problem in the future and we are particularly interested in digging into squamous cell carcinoma of the tongue. REVIEW OF RELATED LITERATURE • Squamous cell carcinoma, mostly malignant, is the most common primary carcinoma of oral cavity accounting for more than 90% of all tumors, whereas metastatic tumors to oral cavity account for 1%-1.5% of all tumors. Oral cancer is referred to as a subgroup of head and neck malignant neoplasms affecting the lips, the anterior two-thirds of tongue, the salivary glands, the gingiva, the floor of the mouth, the oral mucosal surface and the palate, with the tongue being the most common location. The peak incidence occurs after the fifth decade of life, most commonly between the sixth and eight decade in men, and rarely in patients under 40 years of age. Yet, current studies reveal a rise in the incidence in this latter group of young patients. The main risk factors for the onset of oral carcinoma are: tobacco and alcohol consumption (both of which a synergistic effect), betel nut, certain dietetic habits, genetic factors, sun exposure, poor oral hygiene and human papillomavirus (HPV) infection. (Slam P, Gale N, et. al. 2017.) • Historically, squamous cell carcinoma (SCC) of the oral cavity has been a disease of older men with medical histories significant for tobacco and alcohol use. Over the past 30 years, the incidence of oral cavity SCC (OCSSC) has been decreasing while the incidence of oropharyngeal SCC (OPSCC) has been increasing. The decline in tobacco uses and the association of the carcinogenic strains of human papilloma virus (HPV) with OPSCC may explain these trends. The incidence of lethal cases due to oral carcinoma remains rather high, not because it is difficult to detect or diagnose but because this carcinoma is routinely detected in the advanced stage of the disease. ETIOLOGY The two most important independent risk factors for the development of tongue SCCA are heavy smoking and alcohol use. Cigarette smoke contains known carcinogens, mainly nitrosamines, and polycyclic hydrocarbons. Alcohol metabolizes into acetaldehyde, which affects DNA repair. Although less known, other important risk factors for the development of tongue cancer are betel use, radiation exposure, immunocompromised states, poor oral hygiene, and genetic factors. Human papillomavirus (HPV) infection is also known to play a role in tongue cancer. More recently, HPV-related carcinoma of the base of the tongue has been linked to an improved response to therapy and improved survival when compared to its HPV-negative counterpart. (N Engl J Med. 2010) DIAGNOSIS The need for a rapid diagnosis and referral of patients to a skilled physician with expertise in the management of tumors of the head and neck is very important because early diagnosis can lead to a reduction in mortality. Any suspicious areas should be biopsied. Incisional or brush biopsy can be done depending on the surgeon’s preference. Direct laryngoscopy and esophagoscopy are done in all patients with oral cavity cancer to exclude a simultaneous second primary cancer. Head and neck CT usually is done and a chest CT or x-ray is done; however, as in most sites in the head and neck, PETCT has begun to play of patients with oral cavity cancer. RISK FACTOR A risk factor is anything that increases a person’s chance of developing SCC. Tobacco use. Using tobacco, including cigarettes, cigars, pipes, chewing tobacco, and snuff, is the single largest risk factor for head and neck cancer. Alcohol. Frequent and heavy consumption of alcohol increases the risk of head and neck cancer. Using alcohol and tobacco together increases this risk even more. Other factors that can raise a person’s risk of developing Oral Squamous Cell Carcinoma include: Prolonged sun exposure. High exposure to the sun, without sun protection measures, is linked with cancer in the lip area. Human papillomavirus (HPV). Research shows that infection with the HPV virus is a risk factor for oral cancer. In recent years, HPV-related oropharyngeal cancer in the tonsils and the base of the tongue has become more common. Sexual activity, including oral sex, with someone who has HPV is the most common way someone gets HPV. There are different types of HPV, called strains. Research links some HPV strains more strongly with certain types of cancers. RISK FACTOR Gender. Men are more likely to develop oral cancers than women. Fair skin. Fair skin is linked to a higher risk of lip cancer Age. People older than 45 have an increased risk for oral cancer, although this type of cancer can develop in people of any age. Poor oral hygiene. Lack of dental care and not following regular oral hygiene practices may cause an increased risk of oral cavity cancer. Poor dental health or ongoing irritation from poorly fitting dentures, especially in people who use alcohol and tobacco products, may contribute to an increased risk of oral and oropharyngeal cancers. Regular examinations by a dentist or dental hygienist can help detect oral cavity cancer at an early stage. Poor diet/nutrition. A diet low in fruits and vegetables and a vitamin A deficiency may increase the risk of oral cancer. Weakened immune system. People with a weakened immune system may have a higher risk of developing oral cancer. (Shanta V, et al. 2003) SIGN AND SYMPTOMS A common first sign of this cancer is an ulcer, sore or bump on Lump in your neck your tongue that doesn’t heal or fade away, and it may bleed Sore throat or persistent feeling that something is caught in easily the throat Signs and symptoms of Squamous Cell Carcinoma may include: White or red patch on the tongue Thickened area on tongue Persistent discomfort or pain in tongue and/or jaw Burning sensation in tongue Numbness in tongue Bleeding from tongue that’s not from an injury Swallowing or chewing problems Difficulty moving tongue or jaw Trouble speaking Bad breath Weight loss Fatigue Loss of appetite CLINICAL MANIFESTATION Appears as reddish rough, thickened, scaly lesion with bleeding and soreness or may be asymptomatic, border may be wider, more infiltrated, and more inflammatory than basal cell carcinoma. May be preceded by leukoplakia (premalignant lesion of mucous membrane) of the mouth or tongue, actinic keratoses, scarred or ulcerated lesions. Seen most commonly on lower lip, rims of ears, head, neck, and backs of the hands. COMPLICATIONS Squamous cell carcinoma of the tongue is a mouth cancer and its treatment can cause several complications, including changes to the appearance of your mouth, difficulty swallowing and speech problem. Sometimes cause emotional problems and withdrawal from normal life. Dysphagia can be potentially serious problem. If small pieces of food enter your airways and become lodged in your lungs, it could trigger a chest infection, known as aspiration pneumonia. (Rivera C. Essentials of oral cancer. Int J Clin Exp Pathol. 2015) TREATMENT Treatment of Oral Squamous Cell Carcinoma Surgery, with postoperative radiation or chemo radiation as needed. For most oral cavity cancers, surgery is the initial treatment of choice. Radiation or chemo radiation is added postoperatively if disease is more advanced or has high-risk histologic features. Selective neck dissection is indicated if the risk of nodal disease exceeds 15 to 20%. Although there is no firm consensus, neck dissections are typically done for any lesion with a depth of invasion > about 3.5 mm. Routine surgical reconstruction is the key to reducing postoperative oral disabilities; procedures range from local tissue flaps to free tissue transfers. Speech and swallowing therapy may be required after significant resections. Radiation therapy is an alternative treatment. Chemotherapy is not used routinely as primary therapy but is recommended as adjuvant therapy along with radiation in patients with advanced nodal disease. Treatment of squamous cell carcinoma of the lip is surgical excision with reconstruction to maximize postoperative function. When large areas of the lip exhibit premalignant change, the lip can be surgically shaved, or a laser can remove all affected mucosa. Mohs surgery can be used. Thereafter, appropriate sunscreen application is recommended. NURSING ASSESSMENT Assessment. The nurse assesses the patient’s skin and oropharyngeal mucosa regularly when radiation therapy is directed to these areas, and also the nutritional status and general well-being should be assessed Symptoms. If systemic symptoms, such as weakness and fatigue, occur, the nurse explains that these symptoms are a result of the treatment and do not represent deterioration or progression of the disease. Monitoring therapeutic and adverse effects. The nurse must be familiar with each agent given and its potential effects, and also, the nurse must be aware of the impact of these side effects on the patient’s quality of life. Stomatitis. Assessment of the patient’s subjective experience and an objective assessment of the oropharyngeal tissues and teeth are important and for the treatment of oral mucositis, Palifermin (Kepivance), a synthetic form of human keratinocyte growth factor, could be administered. Radiation-associated skin impairment. Nursing care for patients with impaired skin reactions includes maintaining skin integrity, cleansing the skin, promoting comfort, reducing pain, preventing additional trauma, and preventing and managing infection. Reducing Anxiety • - Allow patient to express feelings about the seriousness of diagnosis. • - Answer questions; clarify information and correct misunderstandings. • - Emphasize use of positive coping skills and support system. DIAGNOSTIC TEST To make a diagnosis, the doctor will take a medical history and ask specific questions about symptoms. A patient's tongue and neck will be examined and a small, long-handled mirror will be used to look down the throat. • Several tests are used to aid in the diagnosis. These tests include: X-rays of the mouth and throat, including CT (computed tomography) scans (X-rays that show images in thin sections). PET scans (positron emission tomography), which use radioactive materials to identify excessive activity in an organ. This may indicate the tumor is growing. Tongue cancer usually requires a biopsy, a small sample of tissue that is removed from a tumor to diagnose cancer. After the surgeon removes the tissue, a pathologist will examine the cells under a microscope. There are different methods to obtain a biopsy: - Fine needle aspiration biopsy. A thin needle is inserted into the tumor mass and a sample is drawn out by suction into a syringe. Incisional biopsy. A sample is removed with a scalpel (surgical knife). Punch biopsy. A small circular blade removes a round area of tissue. Pan endoscopy. Pan endoscopy is a procedure used to obtain a biopsy when the suspected tissue is at the back of throat or inside nasal cavities. MEDICAL MANAGEMENT Surgery o For mouth cancer, the aim of surgical treatment is to remove any affected tissue while minimizing damage to the rest of the mouth. Photodynamic therapy (PDT) o If the cancer is in its early stages, it may be possible to remove any tumors using a type of laser surgery known as photodynamic therapy (PDT). PDT involves taking a medicine that makes your tissue sensitive to the effects of light. A laser is then used to remove the tumor. Radiotherapy o It uses doses of radiation to kill cancerous cells. It may be possible to remove the cancer using radiotherapy alone, but it is usually used after surgery to prevent the cancer from reoccurring. Chemotherapy o It is often used in combination with radiotherapy when the cancer is widespread, or if it is thought there is a significant risk of the cancer returning. PREVENTION There's no proven way to prevent mouth cancer. However, you can reduce your risk of mouth cancer if you: Stop using tobacco or don't start. If you use tobacco, stop. If you don't use tobacco, don't start. Using tobacco, whether smoked or chewed, exposes the cells in your mouth to dangerous cancer-causing chemicals. Drink alcohol only in moderation, if at all. Chronic excessive alcohol use can irritate the cells in your mouth, making them vulnerable to mouth cancer. If you choose to drink alcohol, do so in moderation. For healthy adults, that means up to one drink a day for women of all ages and men older than age 65, and up to two drinks a day for men age 65 and younger. Avoid excessive sun exposure to your lips. Protect the skin on your lips from the sun by staying in the shade when possible. Wear a broad-brimmed hat that effectively shades your entire face, including your mouth. Apply a sunscreen lip product as part of your routine sun protection regimen. See your dentist regularly. As part of a routine dental exam, ask your dentist to inspect your entire mouth for abnormal areas that may indicate mouth cancer or precancerous changes. EPIDEMIOLOGY Tongue carcinoma is a condition of older males with a history of smoking and/or drinking alcohol. It has a slight male predominance, and the estimated frequency of disease varies widely with geographic location. In the past, there had been a steady decrease in the incidence of the disease, perhaps attributable to a worldwide overall decrease in smoking. However, studies suggest an alarming increasing incidence of both oral and base of the tongue squamous cell carcinoma during the last decades, specifically in women and younger patients without the traditional risk factors of alcohol or tobacco use. This is, in part, believed to be related to the dramatic spike in HPV-associated oropharyngeal squamous cell carcinoma. (Acta Otorhinolaryngol Ital. 2018 Jun;38(3):175-180). PROGNOSIS A recent study using the Surveillance, Epidemiology, and End Results (SEER) database looked at the incidence and survival of oral tongue squamous cell carcinoma. They report that although the incidence is increasing for both oral tongue SCCA and oropharyngeal squamous cell carcinoma, survival has also significantly improved. The study shows that from 1976 to 2015, oral tongue SCCA and oropharyngeal squamous cell carcinoma both showed the highest absolute increase in survival, with conditional survival of over 90% for both diseases independent of the treatment. (Sci Rep. 2020 May 12;10(1):7877) PATIENT HEALTH HISTORY BIOGRAPHIC DATA • Name: Patient C • Case No: 159272 • Date of Birth: April 05, 1950 • Age: 73 • Sex: Male • Civil Status: Widowed • Address: Kasilak, Poblacion, Tubod, SDN • Occupation: None • Father’s Name: [Not Stated] • Mother’s Name: [Not Stated] • Date and Time of Clinical Encounter: May 16, 2023/ 12:05 PM ADMISSION DATA Hospital: Surigao Medical Center Room Number: 301 Room Type: Private Room Date and Time admitted: May 16, 2023/ 12:05 PM Mode of Admission: On Wheelchair May 16, 2023/ 12:05 PM Admitting Vital Signs: Blood Pressure: 80/ 60 Temperature: 38 °C Pulse Rate: 100 bpm Respiratory Rate: 20 cpm SPO2: 97 Weight: 46 kg Chief Complaint: Body Malaise and Loss Appetite Admitting Physician: Catherine C. Jumawan, M.D. Attending Physician: Victor B. Dumngas, MD Impression: Anorexia and Cachexia Diagnosis: Cachexia/Squamous Cell Carcinoma, Tongue Source of Information: Primary source Secondary source : Patient C : SO and Patient’s Chart CLIENT HEALTH HISTORY Clients Profile • Patient C is a 73-year-old male, Filipino citizen born on April 5, 1950, who is permanently living at Kasilak, Poblacion Tubod, Surigao Del Norte. The patient was admitted to Surigao Medical Center due to body malaise and loss of appetite. BRIEF HISTORY OF PRESENT ILLNESS: • On February 20, 2023, Patient C noticed a node in his tongue, and it was painful. Patient C, experiencing difficulty swallowing, which leads to malnutrition, they immediately decided to see a doctor. On March 23, 2023, a patient was admitted to Surigao Doctor Hospital due to inflammation on the right side of his tongue that had a cyst, and then a biopsy was advised. Then, on March 24, 2023, they underwent a biopsy. The result was released on April 13, 2023. On May 16, 2023, the patient was then admitted to Surigao Medical Center due to anorexia, tremors, and cachexia noted for 5 months due to the inability to eat solids due to pain when swallowing. Weight loss with progressive body weakness, thus this admission. PAST HEALTH HISTORY • Patient C's lifestyle is that he is a heavy drinker and cigarette smoker, but he eventually stops his vices due to his illness. He was diagnosed with cancer of the tongue upon a biopsy done by an EENT surgeon and was advised to undergo surgery when physically fit for it. CLIENT HEALTH HISTORY Immunizations • Patient C completed immunizations during childhood. A. Surgical history • The patient underwent biopsy surgery. B. Accidents and injury • Patient C never experienced any accidents or injuries C. Medications • During hospitalization, the patient was taking six (3) prescription drugs such as: o Omeprazole o Cefalixane o Arcoxia o Ensure milk o Amino acid+ multivitamins (moriamin forte) o Feso4 + folic acid o Sodium chloride o Lactulose syrup Family Health History • According to the patient, no one in their family has the disease he has now, but they are susceptible to acquiring high blood pressure. CLIENT HEALTH HISTORY PERSONAL AND SOCIAL HISTORY • Before hospitalization: The patient was able to smoke two packs of cigarettes every day, drink alcohol, and still manage to do daily activities in life. • During hospitalization: After the admission, further therapeutic assessment was done, and after taking the prescribed medication, the patient was able to express minor relief and was advised to be physically fit for surgery. Nutritional Metabolic Pattern • Before hospitalization: The patient eats three full meals a day. There are no food restrictions except for shrimp because he's allergic. The patient experienced a loss of appetite days before admission. The patient is experiencing eating discomfort due to difficulty swallowing and malnutrition. • During hospitalization: The patient, who was on a soft diet, still has a loss of appetite. The patient only eats foods that have a soft consistency and are easy to swallow, and he also drinks milk. Elimination Pattern • Before hospitalization: Patient C shows body weakness and lethargy. The patient does not use any assistive devices.The patient urinates 3–4 times a day in a light yellow color. The client defecates twice a day, in the morning and evening.The stool is formed, soft, and brown. No discomfort or bleeding when defecating. • During hospitalization: Patient C urinates 3–4 times a day in a light yellow color. There is no discomfort during urination. The patient defecates twice a day with a fluid consistency. The patient still shows body weakness. CLIENT HEALTH HISTORY Activity Exercise Pattern Before hospitalization: The patient woke up at 6 a.m. Takes a shower, then eats breakfast. Do chores on his own.In the afternoon, he was able to visit their neighbor. Then take a nap to rest. Patient C is not limited to daily activities. During hospitalization: Patient C wakes up at 5 a.m. and does not have any activity to do. Sleep-Rest Pattern Patient C's sleeping patterns are from 8 p.m. to 6 a.m. every day during hospitalization. The patient doesn’t take any sleeping pill or sleeping aid. Patient C rarely has a sleeping problem. During hospitalization Patient C's sleeping pattern is to go to sleep at 6 p.m. and wake up at 10 p.m. due to the painful right side of his tongue. He is having sleep disturbances. He takes sleeping pills sometimes.. Cognitive Perceptual Pattern Before hospitalization. Patient C's five senses are intact. He is conscious, coherent, and oriented to time, places, events, and people. During hospitalization. There are no changes in his cognitive perception pattern. Still, he is conscious, coherent, and oriented to time, places, events, and people.. CLIENT HEALTH HISTORY Self-Perception Pattern The patient's greatest concern during admission is to get well and to be physically fit so he can have surgery and go back to normal.life and into his family. Role-relationship Pattern The patient speaks Boholano and Surigaonon; he was able to communicate but had difficulty speaking due to a painful right side of the tongue. Fortunately, he was able to express himself verbally. Patient C lives with his family in their own house. He is surrounded with his family, his support system is strong. In terms of needs and assistance, he has family with him. Coping-stress management Pattern Patient C’s coping mechanism with stress is keeping him busy with home chores and bonding with his grandson. Value-Belief Pattern The patient is a Catholic; he goes to church and hears the word every Sunday. PHYSICAL ASSESSMENT GENERAL PHYSICAL SURVEY Patient is properly dressed, lying in bed awake and responsive. With an on-going IVF of D5NM 1L@ 20gtts/min hooked at right metacarpal vein infusing well and regulated. He responds appropriately and shows coordinated movements. He wears Black colored shirt and blue short appropriate for the temperature of the room. Patient shows expressions relevant to his mood. Patient “C” is conscious, oriented and aware of place, time, and people. He listens and responds appropriately as asked and examined. Vital Signs Measurement Temperature: 36.1 degree Celsius Heart rate: 100bpm Respiratory rate: 20cpm Weight: 46kg Blood Pressure: 80/60 Skin: Skin is warm and dry, No edema. Hair has normal integrity GENERAL PHYSICAL SURVEY Head and Face: No scalp lesions or flaking. Head symmetrically rounded upon palpation. No inflammation, lumps and masses noted on the skull. Bilateral corneal reflexes are intact. Eyes: Both eyes were symmetrical, conjuctiva is pink, sclerae white, without jaundice. Eyebrows distributed equally. Irises are uniformly dark-brown. Pupils are round and reactive to light. Ears and Nose: External pinnae are symmetrical with no lesions or abnormalities, no discharge noted. External nose is uniform color and size, both nostrils were patent. Mouth and Throat: Lips are pale and dry. Complete teeth and has teeth anomalies upon inspection. Inflammed tonsils, tongue is swelling, have ulceration and gums are swollen red in color. Neck: Neck is asymmetric have masses in the right digastric anterior belly muscle. Cervical lymph nodes are palpable. Trachea is in mid placement in midline of neck. GENERAL PHYSICAL SURVEY Arms, Hands, and Fingers: Arms are equal in size and symmetry bilaterally: pale, warm and dry to touch without edema. No lesions and bruising on hands and arms. Three flexion creases present in palm. Fingernails are finely cut, clean and clear. No clubbing. Chest: No lesion and rashes were noted. Chest movement is apparent during inhaling and exhaling. Regular breathing, respiratory rate of 20cpm. Abdomen: Symmetrical contour and uniform in color. No tenderness and masses noted, normal active bowel sounds. Legs, Feet and Toes: Legs have no abrasion and wound. Skins are intact, brown, pale and cold to touch without edema. No edema palpated. Toenails are finely cut, clean and clear. No clubbing. Genitalia (female): No bulging or masses in the inguinal area. No presence of pain during urination and in the genital area. REVIEW OF SYSTEM REVIEW OF SYSTEM Integumentary System Patient C has thinner, pale, clear skin but had a pigmented spots both on his hands. No history of scalp lesions or flaking, pigmented lesions, jaundice, cellulitis, or adenopathy. Head, Eyes, Ears, Nose, and Throat (EENT) Head: Patient has no scalp, hair is color black and distribution consistent with no dryness or oiliness and no lesions present. Eyes: The patient has visual problems and wearing reading glasses. Ears: The patient has no history of ear infection, draining ears, lumps or lesions. No discharged (Otorrhea). No history of ear pain (otalgia). Ear Ringing (Tinnitus). Nose: Patient has no history of Nasal Bleeding (Epistaxis), nasal stuffiness. No nasal discharge (Rhinorrhea), laryngitis. Throat: Patient has a lymph node on his right neck (submandibular).. patient has a history of tonsillitis, sore throats bleeding gums (Gingival Hemorrhage) Gastrointestinal System The patient has a history of abdominal pain. REVIEW OF SYSTEM Musculoskeletal system Poor reflexes. No edema at both lower extremities. No inflammations, or bony deformities. No joint pain. No muscle pain. Neurological System Patient is drowsy and not respond easily. Patient has no history of memory loss, seizure. Urinary System Patient has no history of any urinary tract infection. No pain in urination. No discharge. Reproductive System (Male) No history of bulging or masses in the inguinal area. No discharge. Hematologic or Lymphatic Patient has no varicose veins and currently has a lymph node on his neck. Endocrine No history of Diaphoresis. No polyuria. Psychiatric A patient has a history of depression for losing his wife. LABORATORY RESULTS Result Unit Normal Value Hemoglobin 10.6 g/dL 12.0 – 17.0 Anemia Hematocrit 31.3 (Low) % 37 – 54 Anemia RBC 3.37 (Low) x10^12/L 4.0 – 6.0 Anemia MCV 92.9 (High) fL 87+-5 Macrocytic anemia MCH 31.6 (High) pg 29+-2 Macrocytic anemia MCHC 34.0 g/dL 34+-2 Normal RDW 12.4 11.6 – 14.6 Normal Platelet Count 266 x10^9/L 150 – 450 Normal WBC 6.05 x10^9/L 4.5 – 10.0 Normal Neu % 71.3 (High) % 50 – 70 Infection Lym % 14.0 (Low) % 20 – 40 Infection Mon % 9.1 (High) % 0–7 Infection Eos % 4.7 % 0–5 Normal Bas % 0.9 % 0–1 Normal Test Significance HEMATOLOGY RESULTS • HEMATOLOGY • May 16, 2023 • Remarks: • Decreased Hemoglobin and Hematocrit indicates anemia, decreased RBC indicates anemia, increased MCV indicates microcytic anemia, increased MCH indicates microcytic anemia, increased Neutrophils and Monocytes indicates infection and decreased Lymphocytes indicates Infection. BLOOD CHEMISTRY RESULTS • Remarks: • Decreased Sodium indicates hyponatremia and decreased Ionized Calcium indicates hypoparathyroidism. Test SODIUM POTASSIUM IONIZED CALCIUM MAGNESIUM Result Reference/Unit Significance 124.67 (L) 135.00 – 148.00 mmol/L Hyponatremia 3.58 3.50 – 5.30 mmol/L Normal 1.06 (L) 1.10 – 1.35 mmol/L Hypoparathyroidism 2.44 1.7 – 2.4 mg/dL Normal DRUG STUDY DRUG STUDY NO. 1 Generic Name: Omeprazole Brand Name: Losec k-alkali syndrome Adverse Reaction: Classification: Therapeutic class: Antiulcer drugs Prescribed & recommended dosage: 4g Frequency: q24 CNS: Asthenia, dizziness, headache. GI: Abdominal pain, constipation, diarrhea, flatulence, nausea, vomiting, acid regurgitation. Musculoskeletal: back pain, weakness Route of administration: PO, IV Mechanism of action: Inhibits proton pump activity by binding to hydrogenpotassium adenosine triphosphatase, located at secretory surface of gastric parietal cells, to suppress gastric acid secretion. Respiratory: cough, URI Skin: rash Nursing implications: Indication: Symptomatic GERD without esophageal lesions Erosive esophagitis, Pathologic hypersecretory conditions, Duodenal ulcer, Helicobacter pylori infection and duodenal ulcer disease, to eradicate H.pylori with clarithromycin , H.pylori infection and duodenal ulcer disease, to eradicate H.pylori with clarithromycin and amoxicillin, Short-term treatment of active benign gastric ulcer, Frequent heartbur, Dyspepsia Contraindication: Hypersensitive to drug Use cautiously in patients with hypokalemia and respiratory alkalosis and in patients on a low-sodium diet Risk of fundic gland polyps Long-term administration of bicarbonate with calcium or milk can causemil False positive results in diagnostic investigation for neuroendocrine tumors may occur due to increased CGA level. Temporarily stop atleast 14 days Periodically assess patient for osteoporosis Monitor patient for sign and symptoms of acute interstitial nephritis Discontinue drug if sign or symptoms of cutaneous lupus erythmatosus or SLE develop Gstrin level rises in most patients during the first 2 weeks of therapy. DRUG STUDY NO. 2 Generic Name: Cephalexin Brand Name: keflex Classification: Therapeutic class: Antibiotics Prescribed & recommended dosage: 750 g Frequency: q8 Route of administration: IV Use cautiously in patients with history of colitis and in those with re nal insufficiency Adverse Reaction: CNS: dizziness, headache, fatigue, agitation, confusion, hallucination GI: anorexia, diarrhea, gastritis, dyspepsia, abdominal pain, anal pruritus GU: genital pruritus, candidiasis vaginitis Musculoskeletal: arthritis, arthralgia, joint pain. Skin: maculopapular, and erythematous rashes, urticaria Mechanism of action: Inhibit cell-wall synthesis, promoting osmotic instability; usually bactericidal Nursing implications: Indication: Respiratory tract infection caused by susceptible isolates of Streptococcus pneumoniae and streptococcus pyogenes Contraindication: Hypersensitive to cephalosporins Use cautiously in patients hypersensitive to penicillin because of possibility of cross-sensitivity with other beta-lactam antibiotics Drug may increase risk of seizures. Use cautiously in patients with history of seizures If large doses are given monitor patient for superinfection and diarrhea Treat group of A beta-hemolytic streptococcal infections for a minimum of 10 days If anemia develops during or after cephalexin therapy, obtain a diagnostic work-up for drug-induced haemolytic anemia, discontinue drug, and institute appropriate therapy. DRUG STUDY NO. 3 Generic Name: Etoricoxib Brand Name: Arcoxia Adverse Reaction: Classification: • Gastrointestinal effects: Abdominal pain, indigestion, nausea, and potential gastrointestinal ulcers or bleeding. Therapeutic class: NSAID • Cardiovascular effects: Increased risk of heart attack or stroke. Prescribed & recommended dosage: 90 g • Edema and fluid retention: Swelling and exacerbation of heart failure. Frequency: • Hypersensitivity reactions: Rare allergic reactions, including rashes and difficulty breathing. Route of administration: PO • Liver effects: Rare instances of abnormal liver function or liver injury. Mechanism of action: Like any other COX-2 selective inhibitor Etoricoxib selectively inhibits isoform 2 of cyclo-• oxigenase enzyme (COX-2), preventing production of prostaglandins (PGs) from arachidonic acid. • Pregnancy and breastfeeding Other effects: Headache, dizziness, high blood pressure, and visual disturbances. Indication: Nursing implications: Ankylosing spondylitis Assess medical history, allergies, and pre-existing conditions. Gouty arthritis Educate patients about the medication and its potential side effects. Relief of acute pain associated with dental surgery Adjust dosage for elderly or patients with hepatic/renal impairment. Symptomatic relief in the treatment of osteoarthritis Monitor for adverse effects like bleeding, heart events, fluid retention, or liver issues. Symptomatic relief in the treatment of rheumatoid arthritis Be cautious of drug interactions and adjust medications if needed. Contraindication: Avoid Arcoxia during pregnancy and breastfeeding. Hypersensitivity Monitor geriatric patients closely due to higher risk of adverse effects. Active peptic ulcer or gastrointestinal bleeding severe liver impairment Severe heart failure Inflammatory bowel disease DRUG STUDY NO. 4 Generic Name: Albuterol Sulfate Contraindication: Brand Name: Salbutamol Classification: • Therapeutic class: Bronchodilators • Pharmacologic class: Adrenergic beta-2 agonists Prescribed & recommended dosage: Contraindicated in patients hypertensive to drug or it’s ingredients. Use cautiously in patients with CV disorders, hyperthyroidism, or diabetes mellitus and in those who are unusually responsive to adrenergics. Adverse Reaction: CNS: tremor, nervousness, headache, hyperactivity, insomnia, dizziness, Adults and children age 12 and older:2.5 mg by nebulizer, given over 5 to 15 weakness,CNS stimulation, malaise. minutes t.i.d. or q.i.d. EENT: conjunctivitis, otitis media, dry and irritated nose and throat, nasal Frequency: congestion, epistaxis, hoarsness, pharyngitis, rhinitis. • Every 8 hours CV: tachycardia, palpitations, HTN, chest pain, lymphadenopathy, edema. • Given over 5 to 15 minutes t.i.d. or q.i.d. GI: nausea, vomiting, heartburn, anorexia, altered taste, increased appetite. Route of administration: Nasal Mechanism of action: Nursing implications: Relaxes bronchial, uterine, and vascular smooth muscle by stimulating beta2 Advise patient not to chew or crush extended-release tablets or mix them with receptors. food. Indication: To prevent or treat bronchospasm in patients with reversible obstructive airway disease DRUG STUDY NO. 5 Generic Name: Calcium Pantothenic Brand Name: Moriamin Forte Classification: • Therapeutic class: Multivitamins & Minerals • Pharmacologic class: Essential Amino Acids • Folic acid Prescribed & recommended dosage: 1 capsule, per orem Frequency: Twice a day (BID) Route of administration: Oral Mechanism of action: malnutrition, nutrient deficiencies, sarcopenia, pregnancy, lactation; prevention and auxiliary treatment of diseases such as post-operative improvement, convalescence, dysfunction of the liver, biliary duct and pancreas, anemia, auxiliary treatment of tuberculosis, improvement in burns, bone fractures, eczema, urticaria and nephrosis. Contraindication: May color urine yellow Adverse Reaction: • CNS: Headache and unpleasant taste buds. • GI: Diarrhea, GI disorder, nausea, abdominal cramp and vomiting. Nursing implications: Regulate the antioxidant enzyme activity and increase the body's antioxidant capacity by regulating the Keap1-Nrf2/ARE signaling the pathway. Indication: Health maintenance; severe consumption of nutriments such as Assess patient for vital signs of deficiency before and periodically throughout therapy. Assess nutritional status through 24 h diet recall. Determine frequency of consumption off vitamin-rich foods. DRUG STUDY NO. 6 Brand Name: Hemarate FA Classification: Adverse Reaction: • Therapeutic class: Vitamins and Minerals CNS: Headache, insomnia, unpleasant taste bud • Pharmacologic class: Antiemetics GI: abdominal cramp, diarrhea, GI disorder, nausea, vomiting Generic Name: Iron + Folic, Acid + Vitamin B Comple peptic ulcer regional enteritis ulcerative colitis. Prescribed & recommended dosage: 1 capsule, per orem Nursing implications: Frequency: Twice a day (BID) Route of administration: Oral Mechanism of action: • Inhibits proton pump activity by binding to hydrogen-potassium adenosine triphosphatase, located at secretory surface of gastric parietal cells, to suppress gastric acid secreation. Indication: Maintenance of healing of erosive esophagitis. Short-term treatment of erosive esophagitis associated with GERD. Long-term maintenance of healing erosive esophagitis and reduction in relapse rates of da ytime and nighttime heartburn symptoms in patients with GERD. Treatment of pathologic hypersecretion caused by Zollinger-Ellison syndrome. Dyspepsia Contraindication: Hypersensitivity Hemochromatosis check the physicians order. Follow the 14 rights of medication. Advise patient to take medicine as prescribed. Caution patient to make position changes slowly to minimize orthostatic hypotension. Advise patient to consult physician if irregular heartbeat, dyspnea, swelling of hands and feet and hypotension. DRUG STUDY NO. 7 Generic Name: Sodium Chloride Brand Name: Classification: • Therapeutic class: Antacids • Pharmacologic class : Alkalinizers Prescribed & recommended dosage: 4,000 mg, Per Orem Frequency: Thrice a day (TID) Route of administration: Oral Mechanism of action: Renal failure Adverse Reaction: CNS: mood changes, tiredness, muscle weakness, irregular heartbeat, flatulence, hypertonicity CV: hypercalcemia, hypokalemia GI: stomach cramps Respiratory: shortness of breath Nursing implications: Sodium bicarbonate acts as an alkanizing agent by releasing bicarbonate ions. Following oral administration of this medication, it releases bicarbonate which is capable of neutralizing gastric acid. Indication: • Used as an electrolyte replenisher to help prevent heat cramps caused by too much sweating Contraindication: Contraindicated in patients metabolic/ respiratory alkalosis Hypocalcemia Excessive chloride loss Assess fluid balance throughout the therapy, intake and output, edema and lung sounds. Symptoms of fluid overload should be reported (hypertension, edema, DOB) Tablets must be taken with full glass of water Hypertremia manifestations should be assessed and monitored (edema, hypertension, tachycardia, fever, flushed skin and mental irritability) Hypokalemia should also be assessed by monitoring signs and symptoms (weakness, fatigue, polyuria and polydipsia. DRUG STUDY NO. 8 Generic Name: Lactulose Contraindication: Brand name: Constilac Classification: Adverse Reactions: • Therapeutic class: Laxatives GI: flatulence, borborygmi, belching, abdominal cramps, pain, and distention • Pharmacologic class: Disaccharides Initial Dose: diarrhea, Prescribed and recommended Dosage: 30 ml Per Orem Frequency: Every hour of sleep (HS) Route of administration: Oral Mechanism of action: Excessive Dose: nausea, vomiting, colon, accumulation of hydrogen gas, hypernatremia Nursing Implications: • Reduce blood ammonia by acidifying colon contents, thus retarding diffusion of non- ionic ammonia from colon to blood while promoting its migration from blood to colon. In the acidic colon, NH3 is converted to nonabsorbable ammonium ions and is then expelled in feces. Indication: • Prevention and treatment of portal – systemic encephalopathy (PSE), including stages of heaptic precoma and coma, and by prescription for relief of chronic constipation. Contraindicated in patients with low galactose diet. Assess patient for abdominal distention, presence of bowel sounds, and normal pattern of bowel function. Assess color, consistency, and amount of stool produced. Assess mental status ( orientation, level of consciousness) before and per iodically throughout course of therapy. Promote fluid intake during drug therapy for constipation; older adults o ften self- limit liquids. Lactulose induced osmotic changes in the bowel support intestinal water loss and potential hypernatremia. HUMAN ANATOMY AND PHYSIOLOGY INTEGUMENTRY SYSTEM Your integumentary system is the body’s outer layer. It’s made up of skin, nails, hair and the glands and nerves on the skin. The system acts as a physical barrier and protecting the body from bacteria, infection, injury and sunlight. It helps regulate the body temperature and allows to feel skin sensations like hot and cold. MOUTH ANATOMY TONGUE Tongue is a muscular organ in the mouth that aids in chewing, speaking and breathing. The tongue is made of muscles. It’s anchored inside of your mouth by webs of strong tissue and it’s covered by mucosa, a moist, pink lining that covers certain organs and body cavities. The tongue is covered with different types of papillae or bumps and taste buds. The four different types of taste buds, including: Filiform. Located on the front two-thirds of your tongue, filiform papillae are thread-like in appearance. Unlike other types of papillae, filiform don’t contain taste buds. Fungiform. These papillae get their name from their mushroom-like shape. Located mostly on the sides and tip of the tongue, fingiform papillae consis t of approximately 1,600 taste buds. Circumvallate. The small bumps on the back of the tongue are the circumv allate papillae. The appear larger than the other types of papillae. Foliate. Located on each side of the back portion the tongue, the foliate pap illae look like rough folds of tissue. Each person has about 20 foliate papill ae, which contain several hundred taste buds. PHARYNX The pharynx, also known as the throat, is a muscular funnel that extends from the posterior end of the nasal cavity to the superior end of the esophagus and larynx. The pharynx is divided into 3 regions: the nasopharynx, oropharynx, and laryngopharynx. The nasopharynx is the superior region of the pharynx found in the posterior of the nasal cavity. Inhaled air from the nasal cavity passes into the nasopharynx and descends through the oropharynx, located in the posterior of the oral cavity. Air inhaled through the oral cavity enters the pharynx at the oropharynx. The inhaled air then descends into the laryngopharynx, where it is diverted into the opening of the larynx by the epiglottis. PATHOPHYSIOLOGY PATHOPHYSIOLOGY Narrative: The predisposing factors that contribute to squamous cell carcinoma are age, sex, family history, ethnicity, occupation, and exposure to ultraviolet lights. Age 40 above, for males, is much more common to have squamous cell carcinoma. The patient’s age was 73 which still belong to the age group that commonly experiences squamous cell carcinoma. Males are common to have early exposure to SCC because most of them use cigarette smoking. The patient had no family history of any neoplasm conditions. Squamous cell carcinoma is common in the western world as well as in the Philippines in which the patient is living. Smoking is a precipitating factor for the client since patient C smokes 20 sticks per day and this greatly contributes to having oral squamous cell carcinoma. The patient is also an alcoholic in which also contributed to having SCC. Poor diet is manifested on the client as one of the factors that contributed to SCC. Patient C had cachexia in which pale to look and lethargic during assessment, and after calculating his body mass index, he was malnourished. He had been hospitalized twice for having SCC and malnutrition. Cellular aberration happen at the right lateral border of the tongue after the patient was exposed to different factors that contribute to squamous cell carcinoma. The toxins from smoking, alcohol intake and exposure to UV lights damaged the epithelial cells causing hyperproliferative stratified squamous epithelium. Then, the reaction creates pre malignant lesions called leukoplakia and erythroleukoplakia, these are white and red patches that forms in the mucous membranes of the mouth and tongue. Chronic pain, fatigue, and muscle weakness was manifested on the patient. The pre malignant lesions, then proliferates excessively due to genetic changes and finally epithelial cells grow down into underlying connective tissues. Eventually a tumor forms at the right lateral border of the tongue. Tumor cells continue to divide and destroy the underlying tissues. Tissues in the mouth and tongue feel hard and not functioning properly. Tumor invades lymphatic vessels and spreads into cervical lymph nodes in the neck and continues to metastasize. Eventually the tumor turns into oral squamous cell carcinoma, the patient was diagnosed oral SCC after the result of the lymph node biopsy. PATHOPHYSIOLOGY The patient had pale skin, fatigue, body malaise, and alteration of heart rate. Due to chronic inflammation of the mouth and the submandibular section of the neck the patient had been given ceftriaxone omeprazole and arcoxia. The patient had decreased the blood pressure of 80/60 in which he is hypotensive. The patient was restless based on his actions. Meanwhile, tremors, headaches, and apprehensiveness were also present on the client. The patient condition leads into increased pro-inflammatory cytokins and decreased anabolic hormones. The said hormones will create an effect on the patient’s body causing cytokine induced malnutrition which results from the actions of pro-inflammatory cytokines. The tumor necrosis factor and interleukin 1, 6 and 8. Then the patient was anorexic due to poor swallowing with pain and anemia, then cachexia resulting to being malnutrition, associated with decreased turnover of epithelial cells resulting in delayed recovery which may prolong an episode of infectious diarrhea by itself as well as by promoting tissue invasion by other enteropathogens. The diagnosis is now determined, if the illness is left untreated it will cause disrupted signals of the epithelial cells and this will result mucosal ischemia can lead to bacterial translocation of the gut flora, increasing the risk that the patient will present with bacteremia and it eventually becomes tissue infarction. Tissue infarction progresses to bowel necrosis, perforation, and later on will become sepsis/septic shock then organ failure to multiple organ failure then death. Meanwhile, when the said illness will be treated properly through medications or surgical interventions, there will be a restored blood flow. Through surgical interventions and radiotherapy, the dying cells will be saved because they can experience restored blood flow and restored oxygen flow while the dead cells will be removed. Through this, there will be a continuous function of the mucosal membranes and squamous epithelial part of the HEENT and continuous circulation of blood into the body. NURSING CARE PLAN NURSING CARE PLAN NO. 1 Assessment: NURSING INTERVENTIONS Subjective: "Mag hinuktok rakan sija unsahay kay siguro naway an na sija ng pag -asa, kay na feel nija na pabug-at rakan sija sa amo" as verbalized by the SO. Objective: RATIONALE INDEPENDENT: Encourage the patient to share thoughts and feelings. Provide an open environment in which tha patient feels safe to discuss feelings or refrain from talking.. Provide accurate, consistent information regarding diagnosis and prognosis. Avoid arguing about the patient perceptions of the situation. * Altered Behavioral expression * Poor social interactions * decrease in perceptual field Nursing Diagnoses: Anxiety r/t situational crisis as evidence by expressed concerns regarding changes of life events. Planning: • After 8 hrs of nursing intervention, the patient will be able to acknowledge the implications of his fear, as well as to know some relaxation techniques that help alleviate anxiety. Evaluation: • After 8 hrs of nursing intervention the goal has been met. Provides an opportunity to examine realistic fears and misconceptions about the diagnosis. Helps patients feel accepted in their present conditions without feeling judged, and promotes a sense of dignity and control. Can reduce anxiety and enable patients to make decisions and choices based on realities. COLLABORATIVE: Include SO as indicated or patient desires when major decisions are to be made. Provides a support system for the patient and allows SO to be invol ved appropriately. NURSING CARE PLAN NO. 2 Assessment: Subjective: " Dili na sija karajaw mukaon, ginagmay rakan kay sakit kuno itulon" as verbalized by the SO. Objective: abnormal esophageal phase of swallow difficulty iniatiting swallowing Painscale: 7 Nursing Diagnoses: • Impaired swallowing r/t dysphagia secondary to dry oral mocusa. Planning: • After 2 weeks of nursing intervention the patient will be able to demonstrate improved swallowing ability as evidenced by the absence of discomfort when swallowing foods,fluids no evidence of aspirations and ability to ingest foods and fluid. Evaluation: • After 2 weeks of nursing intervention the patient will be able to demonstrate improved swallowing ability as evidenced by the absence of discomfort when swallowing foods, fluids no evidence of aspirations and ability to ingest foods and fluid. Nursing interventions Rationale INDEPENDENT: Determine the clients potentials for swallowing problems, noting age and medical conditions Review the history of the patient medication. Swallowing disorders are specially common in the elderly due to the coexistence of a variety of neurological, neuromuscular, or other conditions. To determine if any medications are one of the factors cause impaired swallowing such as benzodiapines, nsaids, serostomia, etc. Encourage the patient to have rest period To minimize fatigue and pain before swallowing food or drink. COLLABORATIVE: Provide oral hygiene to the patient at Frequent oral hygiene may help to alleviate th least 4hrs as needed. e patient's feeling of dry mouth and improve t heir ability to swallow Monitor the patient's feeding and To determine the ability of the patient to swall swallowing activities. ow. Assess what the patient can safety eat To provide the client with a consistency of fo and drink od and fluid that is most easily swallowed. Nursing interventions Rationale INDEPENDENT: NURSING CARE PLAN NO. 3 Assessment: Subjective: "Mag hinuktok rakan sija unsahay kay siguro naway an na sija ng pag -asa, kay na feel nija na pabug-at rakan sija sa amo" as verbalized by the SO.the patient. Objective: poor eye contact excessive seeking of reassurance exaggerates negative feedback about self overly conforming ; dependent on others opinion hesitant to try new experiences Nursing Diagnoses: • Situational Low Self-Esteem related to social role changes evidenced by Not taking responsibility for self-care. Planning: • The patient will verbalize understanding of body changes, and acceptance of self in the situation. The patient will begin to develop coping mechanisms to deal effecti vely with problems. The patient will demonstrate adaptation to changes/events that hav e occurred as evidenced by the setting of realistic goals and active p articipation in work/play/personal relationships as appropriate. Express positive self-appraisal. Evaluation: After nursing intervention the patient was able to met the goal, ver balize understanding of body changes and acceptance of self in the situation, and develop coping mechanisms to deal effectively with p roblems. Discuss with the patient and SO how the diagnosis and treatment Aids in defining concerns to begin the problem-solving process. are affecting the patient’s personal life, home, and work activities. Encourage discussion of concerns about the effects of cancer and May help reduce problems that interfere with the acceptance of treatments on the role of homemaker, wage earner, parent, and so treatment or stimulate the progression of the disease. forth. Assess negative attitudes and/or self-talk. An individual who is feeling unimportant, incompetent, and not in control is often is unconsciously saying negative things. Assess negative attitudes and/or self-talk. An individual who is feeling unimportant, incompetent, and not in control is often is unconsciously saying negative things. Encourage expression of feelings, anxieties. Facilitates grieving the loss. Help client identify own responsibility and control or lack of control When able to acknowledge what is out of his or her control, situation. client can focus attention on area of own responsibility. Provide emotional support for the patient and SO during diagnostic Although some patients adapt or adjust to cancer effects or tests and treatment phases. side effects of therapy, many need additional support during this period. Use touch during interactions, if acceptable to the patient, and Affirmation of individuality and acceptance is important in maintain eye contact. reducing the patient’s feelings of insecurity and self-doubt. COLLABORATIVE: Refer for professional counseling as indicated. May be necessary to regain and maintain a positive psychosocial structure if the patient and SO support systems are deteriorating. Involve extended family in treatment plan. Increases likelihood they will provide appropriate support to client. Assist with treatment of underlying condition when possible. For example, cognitive restructuring and improved concentration in mild brain injury often result restoration of the positive self-esteem. NURSING CARE PLAN NO. 4 Nursing interventions Assessment: Perform pain assessment each time pain occurs To demonstrate improvement in status or to Subjective: " Sakit ija dila kay hamok luas sanan hubag" as verbalized by the SO. Objective: Distraction behavior Rationale INDEPENDENT: Assess for potential types of pain that may be To aid in understanding reason for severity of affecting client. pain associated with clients condition.. identify worsening of underlying condition/ Facial expression of pain change in physiological parameters sore in the tongue developing complications. observe nonverbal cues and pain behaviors. Pain scale 7 Observations may not be congruent with verbal reports or may be only indicator present Nursing Diagnoses: • Acute Pain related to inflammation and sore of the tongue evidenced by Alteration in muscle tone Planning The patient will report maximal pain relief/control with minimal interference wi th ADLs. The patient will follow the prescribed pharmacological regimen. The patient will demonstrate the use of relaxation skills and diversional activitie s as indicated for the individual situation. The patient will verbalize sense of control of response to acute situation and po sitive outlook for the future. Evaluation: After nursing intervention the patient was able to met the goal report maximal pain relief and demonstrate the use of relaxation skills and diversional activities . when client is unable to verbalize. Monitor skin color and temperature and vital Which are usually altered in acute pain. signs encourage patient to maintain oral hygiene To avoid microbes. COLLABORATIVE: Evaluate pain relief and control at regular To monitor the pain level. intervals. Adjust medication necessary. Administer analgesics as indicated. Collaborate in treatment of regimen as To maintain acceptable level of pain. To treat the patient. underlying Pain medications may include iv dosing, conditions or disease process causing pain. tablets. Nursing interventions NURSING CARE PLAN NO. 5 Rationale INDEPENDENT: Monitor Vital signs To avoid any complications. Encourage the use of relaxation techniques, visualization, May prevent the onset or reduce the severity of nausea, guided imagery, and moderate exercise before meals. decrease anorexia, and enable the patient to increase oral intake. Encourage open communication regarding anorexia. Often a source of emotional distress, especially for SO who wants to feed patients frequently. When the patient refuses, SO may feel rejected or frustrated. Assessment: Subjective: " Dili na sija karajaw mukaon, ginagmay rakan kay sakit kuno itulon" as verbalized by the SO. Objective: Loss of weight with inadequate food intake uscl weakness of muscles required for swallowing or mastication;poor m e tone Sore buccal cavity auscultate bowel sound. Note characteristics of stool To determine ability and readiness of intestinal tract to handle digestive processes. Encourage the patient to eat a high-calorie, nutrient-rich diet, Metabolic tissue needs are increased as well as fluids (to with adequate fluid intake eliminate waste products). Supplements can play an Nursing Diagnoses: important role in maintaining adequate caloric and protein • Imbalanced Nutrition: Less Than Body Requirements related to emotional distress, fatigue, poorly controlled pain evidenced by sore, inflamed buccal cavity Planning: The patient will demonstrate stable weight/progressive weight gain toward the goal with normalization of laboratory values and be free of signs of malnutritio n. The patient will verbalize understanding of individual interferences to adequat e intake. The patient will participate in specific interventions to stimulate appetite/incre ase dietary intake. Evaluation: • After Nursing Intervention the patient was able to met the goal and able to participate in specific interventions to stimulate appetite/increase dietary intake. intake. COLLABORATIVE: Monitor daily food intake; have the patient keep a food diary Identifies nutritional strengths and deficiencies. as indicated. Administer antiemetic on a regular schedule before or during Nausea and vomiting are frequently the most disabling and and after administration of antineoplastic agent as psychologically stressful side effects of chemotherapy. appropriate. Refer to a dietitian or nutritional support team. Provides a specific dietary plan to meet individual needs and reduce problems associated with protein, calorie malnutrition, and micronutrient deficiencies. NURSING CARE PLAN NO. 6 Assessment: Subjective: "Mag inom sija nag tubig ginagmay ra" as verbalized by the SO. Objective: Vitals signs: Nursing interventions INDEPENDENT: decrease fluid intake monitor vitals signs lethargic monitor laboratory results BP: 100/80 mmhg HR=62 bpm RR=16 cpm TEMP=35.1°c Rationale That may cause or be the effect of dehydration To evaluate fluid and electrolyte status. evaluate nutritional status, noting current intake and type of diet encourage increase fluid intake To avoid dehydration Nursing Diagnoses: assess skin and oral mucous membranes for sign • of dehydrations Risk for Fluid Volume Deficit due to insufficient fluid intake Planning: the patient identify individual risk factors and appropriate intervention s. the patient maintain fluid volume at a functional level as evidenced by individually adequate urinary output with normal specific gravity and stable vitals sign. demonstrate behavior or lifestyle changes to prevent development of fl uid volume deficit. Evaluation: • After nursing intervention the patient was able to met the goal maintain fluid volume at a functional level as evidenced by individually adequate urinary output with normal specific gravity and stable vitals sign. That can negatively affect fluid intake. For signs of dehydration, such as dry skin and mucous membranes, poor skin turgor offer a variety of fluids and water-rich foods, Increase the clients daily fluid intake. and make them available throughout the day. Provide encouragement and praise while This approach creates a supportive environment identifying the patient’s progress. and sends a message of caring. COLLABORATIVE: administer medications as appropriate as To stop or limit fluid losses. prescribed provide nutritionally balanced diet or enteral To provide and gain good nutritions feedings, when indicated provide supplemental IV fluids as indicated To avoid dehydration Nursing interventions NURSING CARE PLAN NO. 7 Rationale INDEPENDENT: Assess for conditions that affect speech Neurological conditions such as stroke, tumors, cerebral palsy, autism, or other hearing impairments can affect the patient’s ability to verbally communicate. Assess for a language barrier If a patient does not communicate effectively or seems to refuse to communicate, ensure they are being spoken to in their native language. Assessment: Subjective: as verbalized by the SO. " Dili sija makastorya kay hubag ija dila" Objective: difficulty comprehending communication difficulty expressing thoughts verbally difficulty speaking verbally Nursing Diagnoses: Impaired verbal communication related to physical barriers evidenced by inflamed tongue Planning: the patient will verbalize or indicate an understanding of the com munication difficulty and plans for ways of handling. establish method of communication in which needs can be expres sed. participate in therapeutic communication. demonstrate congruent verbal and nonverbal communication. use resources appropriately. Evaluation: After nursing intervention the patient was able to met the goal est ablish method of communication in which needs can be expressed Continue speaking to the patient even if they can’t Patients with a tracheostomy or physical barrier or respond who have dysphagia or dementia should still be spoken to as a person. assess the style of speech To communicate in a sign language or gestures. establish rapport with client, initiate eye contact, shake To make patient for comfortable. hands, address by preferred name, and meet the family member present. advice other healthcare communication deficits providers of client To minimize the clients frustration and promote understanding. maintain a calm, unhurried manner. Provide sufficient Individuals with expressive aphasia may talk more time for the client to responds easily when they are rested and relaxed and when they are talking to one person at a time. Maintain eye contact with patient when speaking. Patients may have defect in field of vision or they Stand close, within patient's line of vision (generally may need to see the nurses' face or lips to enhance midline). their understanding of what is being communicated COLLABORATIVE: Provide systemic or topical analgesics as prescribed This will provide comfort and relieve pain. NURSING INTERVENTIONS RATIONALE INDEPENDENT: NURSING CARE PLAN NO. 8 Assessment: Subjective: “Walay gana mokaon kay sakit iyang dila” as verbalized by the SO. Objective: Decreased Body Temperature V/S taken as follows: Monitor Vital signs It helps to detect other possible medical condition and monitor the wellbeing of the patient. Practice and emphasize constant and proper hand hygiene A first-line by all caregivers between therapies and clients. Wear gloves infections. when appropriate to minimize contamination of hands, and discard after each client. Wash hands after glove removal. Instruct the client/significant other (SO)/ visitors to wash hands, as indicated. defense against healthcare-associated Monitor the client’s visitors and caregivers for respiratory To limit exposures, thus reducing cross-contamination. illnesses. Ask sick visitors to leave client area or offer masks and tissues to client or visitors who are coughing or sneezing. Perform or instruct daily mouth care. Include use of At high risk for healthcare-associated antiseptic mouthwash for individuals in acute or long-term especially in client on a ventilator. care settings. infections, T: 35.1 Maintain sterile technique for all invasive problems procedures. P: 62 Cleanse incisions and insertion sites per facility protocol To reduce the potential for catheter-related with appropriate antimicrobial topical or solution. bloodstream infections, and to prevent the growth of R: 16 bacteria. Nursing Diagnoses: COLLABORATIVE: • Infection related to Malnutrition as evidenced by decreased of Body Temperature. Administer/monitor medication regimen and note the To determine effectiveness of therapy or presence of client’s response. side effects. Planning: • The patient will remain afebrile and achieve timely healing as appropriate. Evaluation: • After rendering nursing interventions, the goal partially meet. Maintain adequate hydration, stand or sit to void, and To avoid bladder distention and urinary stasis catheterize, if necessary Provide regular urinary catheter and perineal care. This reduces the risk of ascending urinary tract infection Emphasize the necessity of taking antivirals or antibiotics, as Premature discontinuation of treatment when client directed begins to feel well may result in return of infection and potentiation of drug-resistant strains Discuss the importance of not taking antibiotics or using Inappropriate use can lead to development of drug“leftover” drugs unless specifically instructed by healthcare resistant strains or secondary infections. provider. NURSING CARE PLAN NO. 9 Nursing interventions Rationale INDEPENDENT: Assess vital signs To evaluate fluid status and cardiopulmonary response to activity. Ask the client to rate fatigue (using a 0- 10 or similar numerical scale) and its effects on the ability to participate in desired activites.. Interview parent/caregiver regarding specific changes observed in child or elder client. Fatigue may vary intensity and its often accompanied by irritability, lack of concentration, difficulty making decisions, problems with leisure, and relationship difficulties that can add to stress level and aggravate sleep problems. These individuals may not be able to verbalize feelings or relate meaningful information. Encouraged nutritionally dense, easy- to- prepare- and consume foods, and avoidance of caffeine and highsugar food and beverages. Assessment: Subjective: Insufficient energy Tiredness Rest requirements Objective: V/s: Temp: 38°C HR: 100 bpm RR: 20 cpm BP: 80/ 60 mmHg Nursing Diagnoses: • Fatigue related to physiological condition (malnutrition). • Planning: • After rendering of nursing intervention the client will report an improved sense of energy. Promote overall health measures (e.g. nutrition, adequate fluid intake and appropriate vitamin and iron supplementation). COLLABORATIVE: Assist with self- care needs, keep the bed in a low position and keep travel ways clear of furniture, assist with ambulation as indicated. Refer to comprehensive rehabilitation program, physical and occupational therapy for programmed daily exercises and activities. To improve stamina, strength, and muscle tone and to enhances sense of well- being. Review medication regimen/ use. Certain medications, including prescription ( especially beta- adrenergic blockers, chemotherapy), over- the- counter drugs, herbal supplements, and combinations of drugs and or substances, are known to cause and/or exacerbate fatigue. Evaluation: • After rendering of nursing intervention the client will report an improved sense of energy. To promote energy. DISCHARGE PLAN DISCHARGE PLAN Medication: Instruct the patient significant other (S.O) to contibue taking prescribed medications such as Calcium pantothenic BID, Iron+Folic, Acid-Vitamin B Conple BID, Sodium Chloride TID, Lactulose HS , Omeprazole , Cephalexin, Arcoxia, Ensure milk for feeding Emphasized to the patients significant other (S.O) that the frequency of taking medications should be followed as prescribed by the physician. Emphasized to the patients significant other (S.O) about the importance o taking the medications, since it is only to his healing development. Environmental Consideration:Provide a clean environment. Maintaining cleanliness inside and outside in the house at all times. Treatment: Advised the patients significant other (S.O) to follow to take the medications properly as prescribed by the physician and discussed on the importance of strict adherence to medications. Instruct patient significant other (S.O) to follow proper instructions medications prescribed by the physician (dosage). Instruct the patient significant other (S.O) to understand and follow discharge plan instructions religiously and accurately. Health Teaching: Encouraged the patient maintain good personal hygiene. Advised the patient to stop smoking and drinking alcohols. Instruct the patient to have a complete bed rest. Out-patient check-up:` Instruct the patient significant other (S.O) to have a check-up or to consult physician once a while to monitor patient’s condition and for detection of recurrences and other complications that may arise on to it. Remind the patients significant other (S.O) to consult the physician when signs and symptoms is observed. Diet: Encouraged nutritious foods. Instruct the patient significant other (S.O) to have a diet plan for appetite. Spiritual: Encouraged the patient significant other (S.O) to pray for fast recovery and for good health of the patient. Encouraged the patient significant other (S.O) to always believe in God Almighty. Advised the patient significant other (S.O) to pray every day APPENDICES GENOGRAM APPENDICES IV CHART NO. OF BOTTLE DATE SOLUTION VOLUME ADDITIVE RATE OF FLOW TIME 5/16/23 1 1L D5LR 200cc/hr 5/17/23 3 1L D5NM 20gtts/min 4:18 pm 5/18/23 2 SD Dextrose + Multivitamins 80cc/hr 12:00 mid VITAL SIGNS MONITORING SHEETS Date/Time Blood pressure Pulse Rate Respiratory Rate Temperature Oxygen Saturation 4:00 PM 90/60 56 20 36.9 97% 8:00 PM 100/60 73 21 36.6 96% 12:00 MN 100/70 74 20 36.4 97% 4:00 AM 100/60 58 20 36.4 97% 8:00 AM 90/60 55 20 36.4 97% 12:00 NN 100/70 64 21 36.1 98% 4:00 PM 90/70 60 21 36 97% 8:00 PM 100/60 74 21 36.1 97% 12:00 MN 100/70 58 22 36.3 96% 4:00 AM 100/60 60 21 36 97% 100/60 53 20 36.4 97% 5/16/23 5/17/23 5/18/23 8:00 AM APPENDICES INPUT AND OUTPUT IVF Date Clinical shift Oral Fluid Intake Total Urine Credit Consumed 4PM-12MN 800ml 200ml 200ml 400ml 100ml 12MN-4AM 410ml 390ml 500ml 890ml 100ml Vomitus Stool _ _ _ _ Total 100ml 5/16/23 TOTAL = 5/17/23 TOTAL = 1,290ml TOTAL = 4AM-8AM NH 410ml 50ml 460ml 150ml 8AM-12NN 800ml 200ml 420ml 620ml 100ml 12NN-4PM 550ml 330ml 400ml 730ml 150ml 1,810ml TOTAL = 100ml 200ml _ _ _ _ 150ml 1x 100ml+1x 1x 150ml+1x 400ml+2x DEFINITION OF TERMS • Squamous cell carcinoma: Cancer that begins in cells that form the epidermis (outer layer of the skin). • Metastases : the development of secondary malignant growths at a distance from a primary site of cancer. • Synergistic effect: the interaction of two or more drugs when their combined effect is greater than the sum of the effects seen when each drug is given alone. • Human papillomavirus: A type of virus that can cause abnormal tissue growth (for example, warts) and other changes to cells. • Carcinogen: a substance capable of causing cancer in living tissue • Nitrosamines: A type of chemical found in tobacco products and tobacco smoke. • Polycyclic hydrocarbons: a class of chemicals that occur naturally in coal, crude oil, and gasoline. • Biopsy: procedure to remove a piece of tissue or a sample of cells from your body so that it can be tested in a laboratory. • Cachexia: a complicated metabolic syndrome related to underlying illness and characterized by muscle mass loss with or without fat mass loss • Anorexia: an eating disorder and serious mental health condition • Anemia: a condition in which the body does not have enough healthy red blood cells. • Malnutrition: deficiencies or excesses in nutrient intake, imbalance of essential nutrients or impaired nutrient utilization. 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