BIO1140: Introduction to Cell and Molecular Biology-Winter 2024 Table of contents Course description ..................................................................................................................... 1 Indigenous affirmation ................................................................................................................ 2 Personnel................................................................................................................................... 2 Course format ............................................................................................................................ 2 Course information & content ..................................................................................................... 2 Learning outcomes .................................................................................................................... 3 Textbook .................................................................................................................................... 3 Equity, diversity, and inclusion ................................................................................................... 3 Academic integrity...................................................................................................................... 4 Content ownership ..................................................................................................................... 4 Bilingualism ................................................................................................................................ 4 Evaluations ................................................................................................................................ 5 Grading scheme......................................................................................................................... 6 Consulting midterms & final exams ............................................................................................ 7 Remarking requests ................................................................................................................... 7 Absences and deferral of the final exam .................................................................................... 8 Withdrawing from the course...................................................................................................... 8 Academic accommodations ....................................................................................................... 9 Mentoring centre ........................................................................................................................ 9 Health and wellness ..................................................................................................................10 Course description Welcome to BIO1140! This course addresses the fundamentals of cell and molecular biology. We will cover the structure and varieties of cells, the cytoskeleton, cell membranes and the various transports we can observe across them. We will also look at the general principles of cellular metabolism, cell communication and the cell cycle. Finally, we will study the mechanisms of replication, transcription, and translation as we go from the genes to the proteins they code for. All these concepts will be illustrated with numerous examples. A somewhat more detailed topic list is provided further below. 1 Indigenous affirmation We pay respect to the Algonquin people, who are the traditional guardians of this land. We acknowledge their longstanding relationship with this territory, which remains unceded. We pay respect to all Indigenous people in this region, from all nations across Canada, who call Ottawa home. We acknowledge the traditional knowledge keepers, both young and old. And we honour their courageous leaders: past, present, and future. Learn more here. Personnel Professor: Dr. Vahideh Hassan-Zadeh - vhassanz@uottawa.ca Lab Coordinator: Dr. Fabien Avaron - fabien.avaron@uottawa.ca Large Class Coordinator: Marc Charette - marc.charette@uottawa.ca All emails should have BIO1140A, B or C in the subject line and your name and student # as a signature at the end. You should contact the professor for questions related to lecture material. Contact Marc Charette for logistics, marking, deferred exams, accommodations, and all other non-lecture/course content related issues, and Dr. Fabien for lab-related topics. Please review this syllabus and other course material on the Brightspace website prior to emailing any course personnel. (Note the labs have a separate Brightspace website: here.) We have put significant effort into making these documents as comprehensive as possible, and often the answer to your question is already there. Time, we spend providing information that is already in the syllabus is time we cannot spend on other aspects of the course. With ~1,100 students, this can be substantial. Course format All lectures will be in-person. Presentations will be posted on Brightspace weekly. In order to do well in the course, you must keep up with the material and read the content prior to coming to class. We strongly encourage you to attend the classes as students perform significantly better in exams when they interact with their peers and the instructor. We have designed the course to be accommodating of challenges you may be facing, and we encourage you to make use of the many resources outlined below if you are having difficulty achieving your goals. Course information & content All content and information related to the course will be available on the Brightspace course website. Important announcements will also be made there. The lab component has a separate website (here). Check both regularly and thoroughly, especially prior to emailing any question as the answer is often there already. The course covers 11 modules, they are: 1. 2. 3. 4. 5. 6. 7. 8. 9. Introduction to Biology Cell Structure and Varieties Cell Membrane Structure Cell Membrane Transport Cell Metabolism and Energy Generation Cell Communication Cell Cytoskeleton and Motility Cell Cycle and Cell Division Cell Genetic Material Duplication (DNA replication) 2 10. Cell Protein Synthesis (Transcription and Translation). 11. Cell Protein Trafficking Learning outcomes Learning outcomes are skills that you will acquire in this course and that will help you prepare for the evaluations. These are used by the instructor to design the lectures, the learning activities, and the evaluations, so it is useful to review them as you study for the course. Broad-level learning outcomes are given below; more specific learning outcomes are also provided with each course topic in the videos/slides. By the end of this course, you should be able to… Describe the fundamental principles of cellular biology Apply these principles to current biological questions of today Associate cell structures with their functions Predict movements of molecules inside and outside of the cell and highlight their biological importance Explain the principles of metabolic reactions that occur in cells Describe mechanisms related to cell communication, cell growth, cell division, DNA replication and protein synthesis. Textbook The course is based on material provided in the lectures and Smart Biology Videos. The evaluations (online quizzes, the midterm and the final exams) will be based on this. There is no supported textbook for BIO1140. However, we would like to share some resources that you might find useful as a complement to the lecture material (the most relevant books for this course are in bold): Life: The Science of Biology, David Sadava (12th edition): Click here Essential Cell Biology, Bruc Alberts (any edition): Click here. Molecular Cell Biology, Harvey Lodish (any edition): Click here. Biology 2e from OpenStax (free): Click here. Campbell Biology (any edition): Click here. Karp's Cell and Molecular Biology (any edition): Click here. Again, you will not be directly tested on readings from these textbooks; they are optional to help with your comprehension of some of the lecture material. Equity, diversity, and inclusion In this course, students of all races, colours, cultures, ethnicities, religions, genders, and sexualities are welcome. We commit to providing a learning environment that fosters diversity, equity, and inclusion. A commitment to EDI is a process that requires ongoing action and reflection. We recognize the importance of this commitment to promoting a healthy educational community and to the success of all students. EDI actions and resources: 3 uOttawa’s Academic Accommodations Service is available to all students to help provide an equitable opportunity to fully access and participate in the learning environment with dignity, autonomy and without impediment, while preserving academic freedom, academic integrity, and academic standards. See the ‘Academic accommodations’ section below for more details concerning SASS registered accommodations. The uOttawa library also provides a range of facilities and services to support accessibility. Details here. BIO1140 is a space of respect for each other, including students, teaching assistants, staff, and professors. In support of this, as a code of conduct, we require that participation in this course is based on principles of inclusion, respect, and tolerance. We cannot, and will not, accept abusive or discriminatory behavior online or in person. Academic integrity Academic integrity is fundamental to all scholarly activity. Every member of the University community has the moral obligation to learn and share knowledge with honesty and integrity. Students should be proud to show their diploma, knowing that they have earned it honestly and by respecting the principles of academic integrity. Academic misconduct and plagiarism create irreparable inequities in our community by devaluing the work of others. Let's learn together instead! Because academic integrity is so important, uOttawa created the following website to provide you with information and tools to identify and avoid academic misconduct, and to understand its consequences, accessible here. With respect to all BIO1140 evaluations (i.e., quizzes, midterm and the final exam), you are expected to work individually, not to pass off the work of others as your own (i.e. no plagiarism), and not to post questions or answers online. Violations of this policy can result in serious repercussions that range from a zero on a question or an entire evaluation, to failing the course, suspension, loss of scholarship, or even expulsion. Academic misconduct is a very serious issue, and we treat it as such. Cases will be dealt with following uOttawa’s procedures outlined in Academic regulation A-4 - Academic Integrity and Academic Misconduct. Content ownership The materials you receive for this course are protected by copyright and to be used for this course only. You do not have permission to upload the course materials, including any lecture recordings you may have, to any website. If you require clarification, please consult course personnel. Bilingualism Every student has the right to require that a course be given in the language used to describe the course in the course calendar (Academic Regulation A-1). Except in programs and courses for which language is a requirement, all students have the right to produce their written work and to answer examination questions in the official language of their choice, regardless of the course’s language of instruction. 4 Evaluations There will be 2 online quizzes, 8 Smart Biology quizzes, one midterm, a final exam and laboratory assignments (the latter are detailed on the BIO1140 Laboratory Brightspace website. You are expected to work individually (i.e. on your own) and you will sign a pledge to this effect prior to these examinations. Deferral requests or sick notes will not be accepted for the quizzes. The first online quiz will count for 7.5% of your final grade and will be available on Brightspace on Friday February 16th at 12pm. There will be 18-25 multiple choice questions covering modules 1-4 and contents in the Smart Biology units “From atoms to cells” and “Basic Cell Biology”. You will have a single attempt and once begun, you will have 2 hours to complete this quiz and it must be submitted before February 18th 11pm. The second online quiz will count for 7.5% of your final grade and will be available on Brightspace on Friday March 29th at 12pm. There will be 18-25 multiple choice questions covering modules 6-8. You will have a single attempt and once begun, you will have 2 hours to complete this quiz and it must be submitted before March 31st 11pm. The 8 Smart Biology quizzes will be available on the Smart Biology Website. Smart Biology is an online learning tool which is specially conceived for introductory courses in cellular biology and offers a dynamic and active learning experience. You must purchase a student account on Smart Biology Website with your @uottawa.ca email address. If you use another email address the grades will not be considered. The price will be 48.00 dollars tax included. If you have already purchased this tool, you should still have access to it but to retake the quizzes you must reset all the quizzes. You will find videos organized in three units entitled "From Atoms to Cells, "Photosynthesis and Respiration" and "Basic Cell Biology". The total showtime for the videos is 2 hours and 30 minutes. It is compulsory to take the quizzes in the unit "Photosynthesis and Respiration" (covering the module 5 of the course). There will be a total of 8 Smart Biology quizzes and 74 questions in this unit. The quizzes in this unit will count for 10% of the final grade. Only a single attempt is permitted. It is not compulsory to take the quizzes of the two other units and the quizzes of these units will not be counted towards your final grade. However, there will be questions in the midterm and final exam on the content of all three Smart Biology units. All Smart Biology quizzes will be available from January 21th until February 25th on the Smart Biology website. You can watch these modules at dates specified on the course Brightspace page. All quizzes must be taken prior to February 25th 11pm. The midterm will be held in-person and during class: Section A will have their midterm during class on February 27th. Section B and C will have their midterm during class on February 26th. It will cover the modules 1-5 and Smart Biology contents. You must write the midterm associated with the course section in which you are enrolled (e.g., if you are enrolled in Section A, you must write the midterm on Tuesday, Feb. 27th at 11:30am in-class; you cannot write the midterm for one of the other sections). If you attempt to write in another section any midterm exam that you do write will be disqualified (i.e. will not be marked) and you will be asked to leave the exam. Deferred midterms are NOT offered. If you are ill or otherwise miss the midterm, you do not need to justify your absence; we do not want a doctor’s note or other such letter. The course grading scheme (detailed below) provides options that reweight the missed midterm. This will automatically be applied. With this in mind, we recommend that you do not write the midterm if you are sufficiently ill that you feel it will impact your performance. The mark 5 obtained for the midterm will count, even if a medical certificate is retroactively obtained. You can skip midterm, but there are VERY GOOD reasons why you should not; these are outlined in the grading scheme below. The final exam will be scheduled by the Faculty of Science sometime during the designated final exam period (Apr. 12-25, 2024). It will also be in-person and will cover all material in the course (i.e., it is cumulative) and Smart Biology content. We have no control over the choice of dates nor when this is announced. Information about absences and deferred final exams can be found further below. The precise structure of the midterm (and the final exam) will be communicated closer to the date, but there will always be a mix of multiple choice and short answer questions. The midterm and the final exam will be closed book, meaning that you will not have access to any notes or aids, unless specified by Accommodation Services. Unauthorized electronic devices are not allowed and should not be within your reach (e.g., in your pocket). Phones and devices (e.g., smart watches, unauthorised calculators, etc.) must be turned off and put away in your bag. Failing to do so may result in an allegation of academic fraud. We will be taking attendance during the final exam. Please sign the attendance sheet. A complete exam package (i.e., scantron, exam booklet and exam sheet) need to be returned in order for your exam to be considered complete and properly submitted. We reserve the right to refuse to mark any exam that is incomplete. Lastly, answers to multiple choice questions need to be transferred to the scantron in the appropriate manner, and answers to the short answer questions must be placed in the exam booklet as specified, for them to be marked. We will not transfer multiple choice answers to the scantron, nor mark the exam sheet in any way. Answers not placed in the designated locations will not be marked. Grading scheme We will calculate your mark in the following way: First online Brightspace Quiz............................................... 7.5% Second online Brightspace Quiz................................ ..........7.5% Midterm ………………………….………………………….… 15% 8 Smart Biology Quizzes…………………………….……... 10% Final exam (cumulative) ………………………….……………35% Laboratories………………………….……………………….....25% If you miss the midterm the weight will be transferred to the final exam. A minimum final grade of D (50%) is required to pass the BIO1140 course (this includes the 25% from the labs). You must write the final exam. Student obtaining less than 35% on their final exam will automatically receive a maximal final letter grade of E (49%) in the course. Policies for the lab component of the course are detailed on the Brightspace labs website 6 Consulting midterms & final exams The midterm will be handed back by a TA at various sessions that will be posted on the course website. These will be in the 1st floor lobby of BSC. Please note that picking up your midterm outside these specified sessions is not possible, so please ensure that you attend one of them if you want to pick up your midterm. Due to provincial privacy legislation, you will need to present your uOttawa student ID card or U-Pass to pick up your exam, no exceptions possible. You will be allowed to consult your final exam during sessions that will be held during the month of May. The schedule will be posted on Brightspace once final exams have been marked. If you want to consult your final exam you will need to attend one of these sessions and provide your uOttawa student ID card, again no exceptions. Remarking requests Requests to remark a midterm or the final exam must be based on academic grounds (i.e. an error in marking). Non-academic grounds, such as the following, will NOT be considered: Deserving more marks because you worked really hard and never missed a class The mark not reflecting the time and effort you put in, or not reflecting your understanding of the material Getting A’s in all your other courses Being really close to the letter grade cut-off Feeling that the TA marked too hard Not feeling well, which interfered with your performance Remarking requests must be submitted within 5 business days of receiving your midterm or final exam mark and must include a DETAILED, written justification (grammatically correct, sentence/paragraph form) that explains, with specific reference to the posted marking scheme, why you feel there was a marking error*. Requests are NOT automatically granted; if the professor disagrees with the justification, the original mark will stand. If a remarking is granted, it is done by a course professor and normally entails remarking the entire evaluation. Note that mistakes in both ‘directions’ are possible in the original marking (i.e., awarding marks that were not justified and not awarding marks that were). Therefore, there is no guarantee your mark will increase upon remarking; it may not change, or it could even decrease. Whatever the outcome, the reassessed grade is considered final. Remarking requests are therefore designed for cases in which you feel there is strong academic grounds. To make a request for a midterm, you must submit your exam booklet containing your detailed written justification to Marc Charette prior to the deadline, which will be specified in an announcement on Brightspace. A remarking request drop off box will be available outside Marc’s office (GNN 281). Remarking will be done for all approved cases after the 5 days deadline. It will only be possible to submit remarking requests for exams written in ink. Exams written in pencil will not be accepted for remarking. Any exam suspected of being modified will not be remarked. Please do not contact us asking when remarking will be complete; an announcement will be posted on the course website when updated grades have been uploaded. For the midterm, you will be able to pick up your remarked midterm afterwards. 7 *If the remarking request is a simple addition error, please follow the procedure mentioned above and clearly state that you are requesting a re-addition of your exam. If possible, please indicate where you believe the addition error occurred. Appealing a remarked midterm or final exam: If, after submitting and receiving your remarked midterm or final exam, you still disagree with the grading, you can choose to initiate a grade review. A grade review is a formal process governed by, and subject to, Academic regulation A-9 (Revision of Grades and Appeal), subsection First stage: Grade review. You must follow the procedure outlined in this regulation. Absences and deferral of the final exam Deferred final exams are the responsibility of the Office of Undergraduate Studies within the Faculty of Science; the BIO1140 instructor and staff have no say whatsoever in the granting and scheduling of deferred final exams, nor in anything else concerning them. Information and procedures concerning deferred finals can be found here. To request a deferred final exam, you will need to provide your justification to the Office of Undergraduate Studies. Acceptable justifications are outlined in section A-8.6 Justification of absence from an examination or of late submission of assignments. You should contact the Office of Undergraduate studies (infosci@uottawa.ca) for any and all questions regarding deferred final exams. Typically, students with a justified absence for the final exam are authorised to write the deferred exam. However, eligibility is not automatic, and you must follow the procedure outlined on their website. The deferred final exam period is from July 7th to July 13th 2024, but scheduling of the BIO1140 exam during this period will be decided by the Office of Undergraduate Studies. Withdrawing from the course We recognize that it is sometime necessary for students to withdraw from the course. This practice is commonly called dropping a course. Please note that withdrawing from the course prior to February 2nd will enable you to receive a financial credit (less administrative fees). Withdrawing from the course prior to this date means that the course will not appear on your transcripts. After this date, it is still possible to withdraw from the course until March 22nd, although you will no longer receive a financial credit. Withdrawing from the course means that you will not need to complete any more evaluations and the course will appear on your transcripts as DR (dropped), and it will not affect your GPA. It is not possible to withdraw after March 22nd. If you simply stop attending a course and do not withdraw, you will receive a grade based on the work you have submitted (including zero for unsubmitted work/unwritten evaluations), meaning you may fail. 8 Withdrawing from a course may affect whether you meet all your program requirements. Be sure to consider all changes very carefully before going ahead. Academic accommodations The Academic Accommodations Service works with other campus services to create an accessible campus learning environment, where students with disabilities have an equal opportunity to flourish. They offer a wide range of services and resources, provided with expertise, professionalism, and confidentiality. Some services they offer Help for students with disabilities in making the transition Permanent and temporary accommodation measures Learning strategy development Adaptive exams Transcriptions of learning material Interpretation (ASL and LSQ) Assistive technologies Please note that specific accommodations (e.g., extra time on evaluations) are only granted through this service. BIO1140 course personnel lack the knowledge and background to diagnose any issues and to recommend appropriate accommodations, whereas the Accommodation Service was designed precisely for this reason. You therefore must go through them for an official accommodation. We cannot, for example, grant extra time on an evaluation in the absence of a documented accommodation from Academic Accommodation Services. Students registered with Academic Accommodations Service for extra time accommodations will receive it for their midterm and final exam. Brightspace quizzes are already designed with extra time accommodations in mind, therefore no extra time will be applied to these evaluations. If you have other accommodations that require action on our part, please contact Marc Charette (marc.charette@uottawa.ca) as soon as possible. We will work with Academic Accommodations Service to try and find a solution that incorporates your accommodations. The start of the academic term is a busy time for the Academic Accommodations Service. Please contact them as early as possible to book a meeting with a Learning Specialist prior to your midterm. Failure to do so may mean that your accommodation is note finalized in time. You can contact them at adapt@uottawa.ca. Mentoring centre The Mentoring centre hub is a one-stop shop for academic support. Whether you are an experienced student or just starting out, you’ll find some great resources to help you succeed. With the Academic support, you can: chat with a mentor seven days a week register for study groups take part in study methods workshops (note taking, time management, exam preparation, stress management, etc.) book an appointment with a mentor 9 Health and wellness Your health and wellness are an integral part of your success. If you do not feel well, it can be hard to focus on your studies. Dedicated professionals and fellow students who care about you are always ready to provide advice and support. Depending on your needs, many activities and services exist to accompany you during your academic journey. Services include: opportunities to connect counselling sessions peer support physical activity wellness activities and workshops spiritual guidance You can make an appointment with a counsellor, join a peer chat, or visit the Wellness Lounge in the Jock Turcot University Centre, second floor, room 203 (Monday to Friday from 10 a.m. to 6 p.m.). You can also access 24/7 professional help through the website. For more information and to access these services, click here. We hope that you will enjoy this course and will have a great and enriching learning experience. Your BIO1140 personnel, Prof. Vahideh Hassan-Zadeh Marc Charette 10