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An Exact Test for Hardy-Weinberg and Multiple Alleles on JSTOR
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JOURNAL ARTICLE
An Exact Test for HardyWeinberg and Multiple
Alleles
Edward J. Louis and Everett R. Dempster
Biometrics
Vol. 43, No. 4 (Dec., 1987), pp. 805-811 (7 pages)
Published By: International Biometric Society
https://doi.org/10.2307/2531534
https://www.jstor.org/stable/2531534
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Abstract
Algorithms for generating the exact distribution of a finite sample drawn from a
population in Hardy-Weinberg equilibrium are given for multiple alleles. The finite
sampling distribution is derived analogously to Fisher's 2 X 2 exact distribution
and is equivalent to Levene's conditional finite sampling distribution for HardyWeinberg populations. The algorithms presented are fast computationally and
allow for quick alternatives to standard methods requiring corrections and
approximations. Computation time is on the order of a few seconds for threeallele examples and up to 2 minutes for four-allele examples on an IBM 3081
machine.
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An Exact Test for Hardy-Weinberg and Multiple Alleles on JSTOR
Biometrics is a scientific journal emphasizing the role of statistics and
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theories and the application, development and dissemination of effective
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biologists, mathematicians, statisticians, and others interested in applying
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Biometrics © 1987 International Biometric Society
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