Ministry of Health Masaka Regional Public health Emergency operations Center. Outbreak Name Date of report Prepared by ANTHRAX OUTBREAK SITUATION REPORT Human B. Anthrax Disease and Animal B Districts affected Country- Uganda Anthrax (Bacillus anthracis) Kyotera 11-December 2023. Investigation start date Nov 23, 2023 Masaka Regional Public Health Emergency Operations Center & Kyotera District health office Key Highlights Today (Last 24 hours) Cumulative Confirmed Cases 00 07 Human cases Suspected Cases 00 25 Probable Cases 00 07 Confirmed Deaths 00 02 Human deaths Suspected Deaths 00 08 Active Cases in Hospital 03 10 Admissions Admissions in Home based Care 03 16 Hospital 00 07 Recoveries Home based Care 00 16 Sudden animal deaths today 00 60 Animal Deaths Animal Vaccinated today 77 Human Samples 37 Samples collected Animal samples 00 21 Environmental Samples 00 01 Alerts received 02 66 Alert Management Alerts Investigated 02 66 ** Affected Sub counties; - Kabira - Kasasa - Kyotera T/C Case definition: Any person with; Onset of skin itching, swelling and any two of the following difficulty in breathing, chest pain, abdominal pain, headache, fever, vomiting and diarrhea in a resident of Kabira sub-county from June 2023 up to date. 1 Ministry of Health Masaka Regional Public health Emergency operations Center. Current Anthrax EpiCurve in Kyotera The Epidemiological Curve depicts Suspect, Probable, and Confirmed Human Cases and Deaths Reported in Kyotera since June 4 No of cases 3 2 1 0 9 Wk 2 15 21 Wk 3 June 27 Wk 4 3 9 Wk 1 Wk 2 15 21 Wk 3 27 Wk 4 July 2 Wk 1 8 14 Wk 2 20 Wk 3 26 Wk 4 1 7 Wk 1 13 Wk 2 August 19 Wk 3 25 Wk 4 1 7 Wk 1 Sept 13 Wk 2 19 Wk 3 25 31 Wk 4 6 Wk 1 12 Wk 2 Oct Date of symptom onset (2023) Al ive Dead PUBLIC HEALTH ACTIONS 1.1 COORDINATION The Ministry of health is fast tracking resources mobilization The district task force continues to meet three times a week The rapid response teams commenced on the development of the Incident Action Plan. The Quarantine restrictions was issued by RDC and is still effective 1.2 SURVEILLANCE AND LABORATORY 2 alerts were reported with a cumulative of 66 alerts. 4 samples (3 whole blood and 1 swab from 3 persons were collected) Cumulatively 03/ 38 human samples tested positive for anthrax Infectious Diseases Institute committed one Vehicle for the Laboratory Pillar for 1 month Tracking of lab processes has started (timelines documented 2 18 Wk 3 Nov 24 Wk 4 Ministry of Health Masaka Regional Public health Emergency operations Center. 1.3 CASE MANAGEMENT AND CARCASS DISPOSAL There are currently 2 active cases in stable conditions at Kalisizo Hospital and 1 at Masaka Regional Referral Hospital. Three patients are receiving home-based care associated with Kalisizo Hospital Safe disposal of animal carcasses has been implemented, albeit with some community resistance. •Conducted home based case visits to patients on home-based care: - Patient 1 showed signs of improvement but still experienced chest pain. - Patient 2, a confirmed anthrax case previously admitted at Kalisizo, had insisted on returning home to Kachanga. He still had a painful wound in the thumb since it had dug deep, At the time of the visit he had resulted to herbs claiming its entunuka. Unfortunately, the herbs have made the whole hand swallow at the back again. He was engaged and agreed to resume his medication. 1.4 RISK COMMUNICATION AND SOCIAL MOBILIZATION On Saturday, December 9th, 2023, RCCE initiatives focused on the Anthrax outbreak involved sensitizing 84 individuals at the Kyotera Seventh-day Adventist church. On Sunday, December 10th, 2023, RCCE activities were conducted, starting with sensitization sessions held at Calidality Ministries International (323) in Kifukamizi village, Kyotera Town council, and another born-again church near the Roman Catholic church in Kyotera Town council, engaging 74 individuals. Notably, within the Kyotera District Local Government (DLG), a team comprising the RDC, DPC, DPO, along with staff from various departments including District production, health, and Town councils of Kyotera and Kalisiizo, in addition to a Ministry of Health representative, convened to sensitize animal traders, milk handlers, meat sellers, butcher men, and restaurant owners in Kyotera T/C (237 people) and Kalisiizo T/C (120 people) on Anthrax prevention and management. Extensive sensitization efforts also targeted over 1000 individuals during the market day at Kakyanga trading center, emphasizing crucial information related to the outbreak. 3 Ministry of Health Masaka Regional Public health Emergency operations Center. CHALLENGES Lack of vaccines for animal and human There is no facilitation to the vaccination teams increasing the cost of Vaccination to the farmers Limited facilitation/fuel to run response activities by the DSFPs Stock out of drugs (antibiotics) at health supplies. Limited cooperation from the community despite intensive social mobilization Facilitation for trainers and field teams Lack of Printing training materials IPC and Biosafety is lacking among veterinary team 4 Ministry of Health Masaka Regional Public health Emergency operations Center. Inadequate human resources by Veterinary department to collects samples Background In June 2023, a cow died on a farm in Kyamayembe Village, Bwamiija Parish, Kabira Sub-county. The meat of the dead cow was sold by meat dealers at a cost between 5000 - 7000/= within the community. Following the consumption of this meat, people started developing itching, rash, swelling and skin lesions especially on the arms/hands. The first sudden human death occurred early July. More animals continued to die on the farm, and the veterinary team was contacted by the farm manager. The team took off samples and informed the farm manager that East Coast Fever was the cause of the problem on the farm. Treatment of the animals on the farm was conducted but animals continued to die. Cumulatively about 24 animals have died since June on that farm with the last death reported on October 31, 2023. The meat from the dead animals reportedly continued to be consumed within the community, and 3 of the affected people were meat dealers. Two more farms were reported to have been affected but knowledge of the exact number of dead animals is still scanty. On October 17, 2023, a joint team of District Surveillance Focal Person (DSFP) - Masaka, District Laboratory Focal Person-Kyotera, WHO Field Coordinator visited the affected villages in Kyotera District and conducted preliminary field investigations. They collected samples (blood and swabs) from 2 suspected cases. Samples were sent to UVRI for VHFs testing and returned negative. Case definitions Animal case definitions 1. Confirmed: Suspected case that is positive by PCR. 2. Suspected: Sudden death of a domestic ruminant with uncloated blood emerging from body orifices Human case definitions 1. Suspected anthrax case: Any person with acute onset characterized by several clinical forms which are; a) Cutaneous form: Any person with skin lesions evolving from over 1 to 6 days from a popular through a vesicular stage to depressed black eschar invariably accompanied by oedema that may be mild to extensive. b) Gastro-intestinal: Any person with abdominal distress characterized by nausea, vomiting, anorexia and followed by fever. 5 Ministry of Health Masaka Regional Public health Emergency operations Center. c) Pulmonary (inhalation): any person with brief prodrome resembling acute viral respiratory illness, followed by rapid onset of hypoxia, dysponea and high temperature, with x-ray evidence of mediastinal widening. d) Meningeal: any person with acute onset of high fever possibly with convulsions, loss of consciousness, meningeal signs and symptoms; commonly noted in all systemic infections, but may present without any other clinical symptoms of anthrax. e) AND has an epidemiological link to confirmed or suspected animal products. 2. Confirmed anthrax case We defined a confirmed anthrax case as a suspected case with PCR-positivity for Bacillus anthracis from a clinical sample i.e. swab from skin lesions/vesicles and blood. Partners for Anthrax Diseases in Kyotera 1 2 Name of partner World Health Organization Ministry of health 3. Infectious Diseases Institute 3 4 Public Health Fellowship Program Masaka REOC Pillar support Coordination, Risk Communication and Surveillance Surveillance, Risk Communication, Laboratory, coordination Coordination, Laboratory, Community engagement, IPC, and Case Management Case detection, Surveillance Active case search, surveillance, coordination Given the fast-evolving nature of this epidemic, errors and omissions are inevitable. The regional Incident Management Team welcomes feedback and any information that could help rectify this. Send any comments and feedback to: E-mail: mohugpheoc@gmail.com Information Sources; District Veterinary officers and Diseases Surveillance focal persons 6