#separator:tab #html:true Antinuclear antibody (ANA) normal valueNegative at 1:40 dilution ANAAutoantibodies directed to nuclear material or cytoplastic material (group of protein antibodies that reaction against cellular nuclear material) ANA use*SLE and other autoimmune disorders Immunofluorescent patterns of ANA"<div><img src=""quizlet-Zt2Z97Tr5JIVfbWzFIQddQ.png""></div>" Rheumatoid Factor (RF) normal valueNegative < 60 units/Ml by nephelometric testing<br>To be considered (+) must be found in dilution of greater than 1:80<br>With titers <1:80 think, SLE, scleroderma, and other autoimmune disorders RF useRA<br>Negative RF does not rule out RA Anticyclic Citrullinated Peptide Antibody (Anti-CCP) normal value<20 units/mL Anti-CCP useUnexplained joint inflammation, especially when RF is negative or below 50 units/mL<br>Appears early in the course of RA, and is found in most patients with the disease Antineutrophil Cytoplasmic antibody (ANCA) normal value<1:20: Not significant ANCA useAid in the diagnosis of granulomatosis with polyangiitis (Wegener granulomatosis) and microscopic polyangiitis<br>Used to follow course of disease, monitor response to therapy, and provide early detection of relapse Types of ANCAProteinase 3-ANCA (highly specific in WG)<br>Myeloperoxidase-ANCA Anti-parietal cell antibody (APCA) normal valueNormally negative<br>Titer levels >1:240 are considered positive APCA useFound in nearly 90% patients with pernicious anemia