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Antinuclear antibody (ANA) normal valueNegative at 1:40 dilution
ANAAutoantibodies directed to nuclear material or cytoplastic material (group of protein antibodies that reaction against cellular nuclear material)
ANA use*SLE and other autoimmune disorders
Immunofluorescent patterns of ANA"<div><img src=""quizlet-Zt2Z97Tr5JIVfbWzFIQddQ.png""></div>"
Rheumatoid Factor (RF) normal valueNegative < 60 units/Ml by nephelometric testing<br>To be considered (+) must be found in dilution of greater than 1:80<br>With titers <1:80 think, SLE, scleroderma, and other autoimmune disorders
RF useRA<br>Negative RF does not rule out RA
Anticyclic Citrullinated Peptide Antibody (Anti-CCP) normal value<20 units/mL
Anti-CCP useUnexplained joint inflammation, especially when RF is negative or below 50 units/mL<br>Appears early in the course of RA, and is found in most patients with the disease
Antineutrophil Cytoplasmic antibody (ANCA) normal value<1:20: Not significant
ANCA useAid in the diagnosis of granulomatosis with polyangiitis (Wegener granulomatosis) and microscopic polyangiitis<br>Used to follow course of disease, monitor response to therapy, and provide early detection of relapse
Types of ANCAProteinase 3-ANCA (highly specific in WG)<br>Myeloperoxidase-ANCA
Anti-parietal cell antibody (APCA) normal valueNormally negative<br>Titer levels >1:240 are considered positive
APCA useFound in nearly 90% patients with pernicious anemia