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KAPS Training Institute Dr Asad
Doctor of Pharmacy (University of Sargodha)
Studocu is not sponsored or endorsed by any college or university
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KAPS Training Institute
By: Dr Asad Mehmood
KAPS Preparatory Tips
1-
Do these recalls as much as you can. Do it on daily basis.
2-
Do doses all the drugs (5-6 Questions come from doses).
3-
Do all the notes which are attached with this email. This is very important because we havesummarized
all the KAPS specific data in these files.
You don’t need to consider any other book at all!
4- Studying CPR is MUST
Specifically, CPR Chapter number:
2,3,5,19,20,21,22,23,24,25,31,32,33,34,35,36,37,38,39,40,41,42,43,44,46,47,48,51
These chapters will cover pharmacology, therapeutics and pharmaceutics. These are more than enough to
pass the exam.
Note: Few chapters of AMH are attached. Preferably study those chapters from AMH and skip those chapters
from CPR which are mentioned above.
5-APEC Calculation book is attached. Practice calculations as much as you can.
6- Classification of Drugs is important.
7- You need to cover, indications, drug interactions, drug-food interactions, doses, practice points and adverse
effects.
8- You should memorize the CYP enzymes either inhibited or stimulated by different drugs (1-3 Questions
always asked).
9- Questions will be from Emulsions, Ointments, Suspensions, excipients (their role) and capsules.
10-FAMOUS drugs for KAPS examiners.
Phenytoin, Warfarin, Digoxin, Paracetamol, Ibuprofen, LMWH, Thyroxine, HTN drugs, GIT drugs,
Methotrexate, Vancomycin, Rifampicin, Amoxicillin, Ampicillin, Fluoroquinolones, Epileptic drugs, Dopamine,
Dobutamine, Lidocaine, Atropine (its source), Hematocrit value, Aspirin, Loop diuretics, thiazide diuretics,
beta blockers, calcium channel blockers and anticancer drug.
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RECALLS
1.
The atom w is at plane in chair…………Equatorial
2.
Structure of ampicillin
3.
Ether
4.
Phenothiazine
5.
Zwitter ion
6.
Amix acid
7.
Ester……………………….Carboxylic acid in w OH is replaced by alkoxy gp.
8.
All of ! following in alkylating agent except……….. Cytrapine.
9.
Structure of oisplatinm…………… 2 cl atoms are adjacent.
10. Acetyl choline………………………….. Choline ester.
11. Angiotensin 2 blocker……………………….. Block type I receptor
12. Angiotensin 2 blocker………………………. Not used if urea is high.
13. DMARD ‘’ Disease modified Anti Rheumatic drugs’’ used if………………….. No relief with NSAID
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14. Mode of Action of Allopurinol…………………….. Inhibit xanthine oxidase enzyme
15. Not characteristic in gout…………………………….. In Women > Men
16. Used in anticholinesterase toxicity……………….. Atropine + Parlidoxime
17. The most causing vomiting…………………………… Cisplatin
18. Not used in Mania……………………………………….. Halloperidal
19. Not Choice in parkinsonism………………………… Jerky movement.
20. Least acidity……………………………………………….. rise pka.
21. Hematocrit value ………………………………………..45-50%.
22. After centrifuging of blood ………………………….Hematocrit value.
23. Amount urine daily ……………………………………1.5 - 2 Litres.
24. Quinidine is D isomer of……………………………. quinine.
25. Difference between quetiapine and clozapine……………………….. Anticholinergic activity.
26. We reach CSS ……………………………………………..4-5 half lifes.
27. Pethidine doesn’t have………………………………… Anti-cough action.
28. Fentanyl……………………………………………………… Pain killer.
29. Has active metabolite………………………………… Morphine.
30. Tamoxifen………………………………………………….. Antiestrogens is breast cancer.
31. SIDE EFFECTS of Tamoxifen………………………… Hot Flushes.
32. In case of hypophosphatemia…………………….. Rise in Calcium Level.
33. Not protease inhibitor………………………………… lamivudine(Anti Cancer).
34. Completely re-absorbed in urine………………… Glucose.
35. Rifampicin and phenothiazine …………………….Enzyme inducer.
36. Fall in Amphetamine toxicity ………………………Acidify urine.
37. Used for anaerobic bacteria ………………………..Metronidazole.
38. Not Absorbed in stomach…………………………… Aminoglycosides + nitrofuran.
39. SE of vancomycin……………………………………….. Ototoxicity and Red Man syndrome.
40. Antidote for methotrexate………………………….. Folinic acid.
41. Not used in Pregnancy………………………………... Nitrofurantoin.
42. In hypothyroidism ………………………………………..Rise in THYROID STIMULATING HORMONE.
43. Cretinism……………………………………………………… Low in infant.
44. Conformation isomer is detected by ……………..NUCLEAR MAGNETIC RESONANCE.
45. Shape of RBC …………………………………………………Non nucleated biconcave.
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46. Drug contain Ketone…………………………………… Phenobarbitone.
47. w is responsible for spermatogenesis ………….FOLLICLE STIMULATING HORMONE.
48. Increase Testosterone controlled by…………… FOLLICLE STIMULATING HORMONE.
49. Least important for physician in choosing anti-Cancer ………………….Age of patient
50. MAOI………………………. Selegiline
51. Limited use of acetazolamide …………………………...Metabolic acidosis and alkaline urine.
52. In case of hyperkalemia don’t use …………………….spironolactone.
53. Chronic heart failure …………………………………………change morphology of left ventricle.
54. Betaxolol is BETA BLOCKERS…………………………….. Fall in Aquous humor formation.
55. Labetalol ……………………………………………………………Alpha & Beta blocker.
56. Dipyridamol ……………………………………………………….Fall in platelet by Thromboxane A2.
57. DRUG OF CHOICS in shock …………………………………dopamine.
58. Vit. Toxicity due to overdose in…………………………. Fat Sol Vit(A,D,E,K).
59. Structure of Ketoprofen.
60. Cyproheptadine ………………………………………………antihistaminic and anti 5HT.
61. PTH, Vit D ……………………………………………………….Fall in excretion of Ca.
62. Dobutamine……………………………………………………. B against.
63. Filgrastum is…………………………………………………… Protein.
64. Saponification ………………………………………………Inorganic base + organic acid.
65. Structure of Cloxacillin.
66. Phenol……………………. not
resist oxidation.
67. Zalmitriptan and Sumatriptan ……………………………SHTD against in Migraine
68. Cause of travellers diarrhea ………………………………..E-Coli.
69. Loop diuretic……………………………………………………… ototoxicity.
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70. Metronidazole used for all except ……………………..E-Coli.
71. Spiranolactone and Eplerenone………………………...Aldosterone Antagonist.
72. Coal tar used in psoriasis prior to cortisone ………. level of cortisone increase in Absence.
73. A verapamil used in…………………………………………… angina arrhythmia, CHF.
74. Estrogen, Diethy L. stilbostend are similar in ………2 Groups on different side (Trans).
75. Calcitonin…………………………………………………………… treatment hyper-calcemia.
76. Vitamin D is………………………………………………………. steroid hormone.
77. Acetazolamide …………………………………….Carbonic Anhydrase Inhibitors, Fall in Potassium level,
metabolicleads to acidosis but not metabolic alkalosis.
78. Na+ level …………………………………………………………..135-147 mmol/L.
79. Acid resistant……………………………………….………….. amoxicillin.
80. Post-pituitary gland secretes……………………………. vasopressin and Oxytocin.
81. Ketoconazole…………………………………………………….. rise in warfarin level.
82. Carbamazepine phenytoin, valproate………………… HME inducer.
83. Allopurinol ………………………………………………………….take lots of H2O with it.
84. Dose of doxyrubicin ……………………45 mg/m2/day
 Allopurinol …………….Xanthine oxidose enzyme inhibition
 Acetazolamide………. carbonic anhydrase enzyme
inhibition
 Zidovudine lamivudine………….. reverse transcriptive
enzyme inhibition
 Statins …………………………………….HMG Co reductase
enzyme inhibition.
85. Cytarabine………………………………………………..….. Antimetabolite.
86. Side effect of Danurubicin……………………………. Cardiac toxicity.
87. Used oral Nystatin ………………………………………..Rise and Swallow.
88. Definition of Conformational ixmer………………. rotation around single band.
89. Amoxicillin …………………………………………………… otitis media.
90. Adrenaline……………………………………………………. Metabolized by COMT.
91. Noradrenaline……………………………………………… Metabolized by MAO.
92. Isoprenaline………………………………………………… B1, B2, Against
93. Aspirin may induce asthma…………………………. shift axhidonic acid to leukotrienes94.
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94. Zidovudine, lamivudine……………………………… reverse transcriptase inhibitor95.
95. Curve of drug in presence of competitive antagonist will be ……………..shift to the right96.
96. Partial seizure ………………………………………………..may be conscious or non-conscious97.
97. Statins …………………………………………………………HMG Co reductase inhibitor98.
98. Ileum…………………………………………………………. last part of small intestine99.
99. N2O……………………………………… Not analgesic. 100. Nitroglycerin ……….……dilate coronary
arteries.
101. Methadone……………………… Not anti tussive aloo.
102. ACEI + MI………………………….. Not usual increase in creatine
103. Moclobemide Max dose………….. 600 mg
104. Atropine …………………………..0.25-2 mg
105. Misoprostol …………………….200 Mcg/q.i.d
106. Glyceryl trinitrate………….. 0.3-1.2 mg
107. Na Phenobarbitone………………………………………….. Basic
108. Side effect of Lithium………………………………………... Diabetes insipidus
109. Side effect of Fluoroquinolones ………………………….Glidiness, dizziness
110. Amiodarone cause all except…………………………….. Hepatotoxicity
111. Sucralfate…………………………………………………………. not taken food or antacid
112. Candesartan………………………………………………..…… rise in K +
113. Cimetidine………………………………………………………. HME inhibitor, CONTRAINDICATED with digoxin
114. Needle gauge inversely proportional to Diameter.
115. Short-acting Benzodiazepine ………………………………Oxazepam
116. A patient suffers from cough + runny nose…………. Guaifenesin + Pseudoephedrine
117. Patient on Lithium ……………………………………………..shouldn’t r estrict Na diet intake
118. Antifungal used topically or IV only…………………….. Amphotericin-B
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119. Drug formulated in micronized form…………………. To decrease the disintegration time
120. Crystal form ………………………………………… Will effect solubility
121. Used for enteric coated………………………… Cellulose acetate phthalate
122. Vehicle for eye drops……………………………… Polyvinyl alcohol
123. Binding of drug to plasma protein not affected by……………………… Molecular weight
124. TPN stored at…………………………………………………………………….. 2-8 Degree
125. Cross sensitivity beta oxacillin and cephalosporin is………………….. 10%
126. Patient having rash often penicillin injection………………………… infectious mononucleosis
127. Best analgesic with METHOTREXATE……………………………………… Paracetamol
128. COX2 inhibitor…………………………………………………………………. Not inhibit thromboxane
129. Probenecid………………………………………………………………………... Rise in activity of Penicillin
130. Active transport………………………………………………….. Low conscious to high conscious
131. CONTRAINDICATED with Methenamine ……………………………Tartrate (basic) any basic drug
132. Diabetes controlled by……………………………………………………… Glucose in blood
133. Side effect of Antipsychotic by………………………………………….. Muscle rigidity
134. In Renal Failure……………………………….. increase in PO4, increase in K, increase in Uric
acid,decrease in Ca2, decrease in Na+
135. Penicillin…………………………………………….. hydrolysis B-lactam
136. Rickettes…………………………………………….. Vitamin D
137. Thiazide…………………………… increase in Uric Acid, increase in Ca+, increase in Glucose and Lipids
138. Sarcolemma found in………………………….. striated muscle tissue
139. Patient on tea and toast diet……………….. Iron deficiency anemia, decrease in MCV.
140. USED IN METASTATIC PAIN…………………… FENTANYL
141. Penicillin differ…………………………………….. In acyl side chain
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142. Appetite modulating drug…………………….. All except Orlistrate
143. In moderate exercise all happened except:
 Increase in CO
 Increase in TPR
 Increase in blood to viscera
  Increase in diastolic pressure
144. Diabetic patient should perform effort……………………………. To raise in Glucose uptake
145. Increase in HR without diastolic………………………………………. Sinus tachycardia
146. Parasympathetic action on urinary bladder……………………… M3
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