Assess the patient Comorbidities and psychosocial conditions Check vital signs, temperature and blood sugar Assess the ulcer Ischemic, Neuro-osteoarthropathic or Neuropathic SINBAD (Site, Ischemia, Neuropathy, Bacterial infection, Area and Depth) assess signs of infection purulence, hotness, redness, swelling or tenderness a Assess biochemical and radiological status CBC, Electrolytes, Creatinine, Cardiac enzymes Inflammatory Markers (CRP, ESR, WBCs, Procalcitonin) Imaging (two View Foot X-RAY, Probe-to-Bone test, Chest X-RAY) Sent tissue culture Severe Infection Deep tissues or bone infection Extensive cellulitis (>2cm) Mild Infection Severe inflammation with necrosis or gangrene Assess Severity of Infection Assess need for admission Severe Foot ischemia Not meet criteria for admission Care of the ulcer (dressing, debridement, offloading) Initiate appropriate antimicrobial regiment Set up follow up visit Presence of the following admission criteria: Admit the patient Acute onset or rapidly progressive course Assess need for debridement or amputation Fever, Dehydration, Hypotension or confusion Start empirical parental wide spectrum antimicrobial regimen for at least one to two weeks if no bone infection and up to 3 weeks if bone infection proved Significant Metabolic abnormalities Maintain adequate fluid volume Highly elevated inflammatory markers Monitor inflammatory markers Presence of foreign body Monitor electrolytes, sugar control, oxygen and metabolic status Require extensive debridement Reassess in 2-7 days NO IMPROVEMENT Reassess the patient clinically at least once daily Reassess need for debridement Regular care of dressing Reassess wound care Check inflammatory markers trending Check patient adherence Consider repeat culture NO IMPROVEMENT Improved Reassess need for surgical intervention (abscess drainage, debridement, amputation) Further patient education Change to oral antimicrobial regimen Consider Advanced imaging (MRI, Duplex, CTA, MRA) Regular follow up Consider outpatient follow up Consider vascular consultation IMPROVED De-escalate antimicrobial regimen Check culture results Escalate antimicrobial regimen