Background of the Study Despite being a prerequisite for students planning to major in STEM, calculus has been demonstrated to deter pupils from pursuing degrees in STEM. According to Hurtado (2018), up to 40% of students who declare a major in science, technology, engineering, or mathematics (STEM) do not earn a STEM degree. This is particularly troublesome in the USA, where it is estimated that in the coming ten years, an additional one million STEM graduates would be needed to meet labor expectations (PCAST 2019). Several mathematics courses are compulsory in all programs of science and engineering students in higher education institutions. The justification for teaching mathematics at senior high school level of education in science and engineering fields is to enable students to handle, use, and interpret quantitative relationships of variables and deal with data in research in their own fields of study. Learning difficulties in differential calculus and reasoning skills prepare students to deal effectively with analytical and statistical tasks of the world of work (Bandura, 2020 and Tobias, 2018). In a broader sense, self-directed readiness is the capacity to take charge of one’s own learning (Holec, 2018). To be specific, self-directed readiness can be defined as a process where the learner takes initiative to discover his or her needs during the process of learning, sets learning objectives, identifies resources, adopts suitable learning strategies and evaluates the outcomes (Knowles, 2019). Knowles (2019) also emphasized that it is the natural progression for learners to pursue autonomous learning so as to learn and remember better in any given learning situation. According to Reinders (2018), it is an integral part to help raise students’ awareness of undertaking learning outside the classroom and preparing them on their path toward autonomy. In addition to awareness, it also requires students to have great amount of motivation as well as diversified learning strategies in order to be take the initiative to pursue a learning experience that is most beneficial in the long run. As such, gauging the level of self-directed learning readiness is crucial as this will indicate whether one has the willingness, motivation and ability to participate in the task (Littlewood, 2020). Wiley (2019) defined self-directed learning readiness as the degree to which an individual possesses attitudes, abilities, and personality characteristics necessary for self-directed learning. In the field of mathematics known as calculus, functions that describe actual processes and quantities are differentiated and integrated (Suwarto, 2013). Five years after the implementation of the K-12 Curriculum, the country's standing in mathematics education did not improve compared to neighboring countries according to 2018 Programme for International Student Assessment (PISA). It revealed that the Philippines scored the lowest in reading comprehension and the second lowest in mathematics and science among the seventy-nine participating countries (San Juan, 2019). Although the value of self-directed learning has been emphasized heavily in educational research, studies examining the connection between STEM students' selfdirected readiness and their mastery of differential calculus in particular schools, like Monkayo National High School, are conspicuously lacking. This research gap emphasizes the necessity to investigate the possible influence of self-directed preparedness on differential calculus students' learning results in order to further our understanding of efficient teaching and learning practices in the subject.