Gynaecology Abnormal Uterine bleeding Acute - - Chronic - - Bleeding Causes of . abnormal AUB PALM : : iatrogenic cause polyp A- Adenomyosis L Leiomyoma p regularity , Uterine / General - of Aetiology - Blood Malignancy Men Causes dyscrasia - - - - - - Ovulatory dysfunction Hyperplasia I - in are 6 months of absence excluded ) . . clinically any This term . attention detectable been has organic replaced by systemic , AUB or completely now . Endometrial - Iatrogenic - N Not - classified : Contraceptives - pelvic adhesions - Uterine fibroids Endometrial - Hormonal NCD . IDUB Ovulatory - Post tubal sterilisation - progesterone only pills Hyperplasia . irregular ripening irregular shedding Italian 's disease) Anorulatory-metropalhiahaemorrhagi.ca/ Schroeder's disease Adenomyosis - - - . Coagulopathy o DID - occurs ( pregnancy and fibroids pelvic causes Coagulopatny thyroid dysfunction Genital TB - orrhagea & bleeding that immediate to require For past timing C- E - - or quantity AGO Classification - M sufficient of Abnormal Classification COEIN - volume in Bleeding Uterine Dysfunctional : heavy menstrual bleeding Episode of Feminizing tumor of ovary Endometriosis Pelvic congestion Investigations - - - - CBC - Bleeding time & - Thyroid function tests - pelvis Diagnostic Hysteroscopy USG - - Endometrial tissue sampling Diagnostic laparoscopy sono Ipingography pelvic angiography if > may show other by D4C detect cause Arteriovenous fistula investigations fail vaniosity & to . .MX menorrhagia v v Older women Young patient I v Rule out u v Conception and contraception desired desired cancer uterine pathology v ✓ Normal Uterus v . Combined 0C Etnamsylate (NSAID) v ' - cantifibn.no/ytic) - u Medroxy progesterone Acetate Norethisterone 5mg Mirena 10mg aid - × ydays - - Releases LNG Effective as • pills contraindicated over 40 years progesterone and others months v No response v Hysterectomy fails with removal of ovaries v 6- A therapy -0C - v v Medical Rough day GnRH analogues 13-4 continue R, for minimally - month or - required follow - invasive surgeries D4C Endometrial ablation QR) up pathology present pills Progesterone Transexamic acid Uterine . Hysterectomy of ovaries with conservation ( 750 years) Appropriate surgery Dysmenorrhea - It defined is as menstruation a painful enough to incapacitate day day aunties to . Secondary (congestive) Primary (spasmodic) . . . pelvic pathology any confined mostly adolescent to presence of - In - Etiology in occurs 2) DID 3) Ovarian cysts & tumors a) Cervical stenosis 5) fibroids myometn.at hyperactivity Uterine 6) , Junctional zone 132) & hyperplasia hyperactivity H Overactivity of sympathetic nerves 8) Intrauterine adhesions 9) Transverse vaginal septum Hyperion; city of circular fibres , of isthumus . 3) RPG Fa ovulatory cycles in Psychosomatic Ischemia > factors anxiety , myometrium of C1F : 11 low pain threshold , Adenomyosis 7) Polyps , Dys peristalsis 4) Endometriosis 11 . theories : 1) Pain starts C1F : menses , 5) Syncope 6) Clinical in hrs . Investigations USG : . reveal any abnormalities - Rule out Given for Mefehamic acid - - - Na broken pelvic pathologies . : days 950 . -500mg 25mg cycles lid tid 275mg lid Hyaline compounds Drotaverine Glycerol trinitrate transdermal patches 0C pills . progesterone releasing - For 3-6 Antispasmodics - . 1-3 : Indomethacin - Trans a) surgery - - to underlying US9 investigations . : NSAIDs - : Routine : medical related CTIMRI , does not cutaneous - IUD Electrical Relieve paint contraceptive benefits nerve stimulation Rarely required Laparoscopic Uterine Nerve ablation ( LUNA) Laparoscopic pre sacral heurectomyll.HN ) relieves with start in nature dull Hysteroscopy - " is severe cases exam Investigations periods and . may radiate to back & medial aspect of thigh may be alw nausea vomiting cold sweats 4 days prior to 3) Other symptoms 1) Pain begins few hours or just before a) Pain lasts for few hours to 24 3) Spasmodic lower abdominal pain ; 4) its of bleeding 2) Pain . pathology pelvic . ovulation cycles & is usually cured pregnancy and vaginal delivery pain always after - of absence In MX : treatment of underlying cause . pathology present PCOS - Definition : Heterogeneous resulting . Incidence 4- 12% : in characterised syndrome complex menstrual irregularity of women , reproductive age in infertility by chronic and anovulation and hirsutism Hyperandrogen Ism Diagnostic Criteria 1) Oligo C1F : ! - Anovulation or Biochemical : or clinical 12 follicles At least US9 : On size I -9mm , - present within t or both ovaries Investigations 1) Serum 4 women young . Hirsutism Acne nigricans male pattern alopecia Acanthus's - Induction agents : Ovulation : Hormone values in 710Mt ovarian volume . seen Infertility - OR Generally obesity Oligomenorrhoea I Amenorrhoea - b) resistance , central - - a) Hyper androgen ism insulin alw . . . frequently ; . DU0M iphone citrate ( Doctor anovulatory infertility) 50mg 1 day for 5 days ( Day 2-6 or 5-9 of cycle) : E2 4 LH - success rate for ovulation -801 . 4 Testosterone & And rostenedione SHBG ( sex Hormone binding globulin) H a- hydroxy progesterone 7300 nglml 4 Prolactin + 2) Letrozole 2.5mg 1 day X 5 20mg days on day 3 - A 2) USG ovaries ( Necklace - - 1 day X 5 days Insulin fasting - , 4) Anastrozole , size 2 -9mm and volume of 4 echo gene city 4 in endometrial thickness 3) Thyroid function tests ( Reserved placed peripherally pattern) of pearls in 4) Laparoscopy 5) Gonadotropin s volume 710mm's follicles 12 or more - 20 -40mg : Enlarged - serum 3) Tamoxifen - unopposed estrogen stimulation women Injection hCG side Effects : . FSH 5,000-10,000 IU Im Multiple pregnancies a) Ovarian Hyper stimulation syndrome 10USD 3) A risk of epithelial ovarian cancer D SX for Ovulation Induction BIL enlarged ovaries - HMG & Recombinant stroma due to obese in - : for therapeutic purpose) - - Only No in cases of risk of OHSS Laparoscopic : failure with Or drilling medical therapy ovarian multiple pregnancy . RI - - . counselling of patient about disease Lifestyle modification Balance diet Regular exercise . : - Insulin sensitizes : - - stop smoking alcohol , specific 14 D - a) Myoinositol : Irregular periods I amenorrhoea : : - - and RI is 4 upto once a day 1000mg twice a day 0C suppress : 0C pills 1 - Newer insulin sensitize Cyclical progesterone pills Anti androgens Ovulation : Antiandrogen s induction Assisted reproductive 4) Hyper insulin emia Best Can be 500mg -0C - 3) Infertility start at . 2) Hirsutism - - Weight loss . . 1) Metformin technology ( ART) Insulin sensitizes : 1) spironolactone 25 -100mg a) Flutamide 3) Fina sterile a) Cyproterone pills as acne and it regularises cycles Hirsutism . acetate twice a day Prolapse Support Uterus : of ( tier Upper ① Endo pelvic fascia ② Round ligaments - - Remnants of gubernaallum function to maintain anteverted position Double layer of Acts - peritoneum attaching Endo pelvic fascia . of Uterus Broad & Round ligaments are - ④ considered False support Genital Prolapse : Downward displacement . Aetiology : . ) ② Birth injuries - - - - nerve Operative delivery injury - - : - Raised intra abdominal C1F symphysis to anterior cervix 1 Cardinal Imackerodt 's ligament cervix to lateral pelvic walls from utero sacral ligaments normal anatomical position its upper 213 : lower yg : Upper 43 . : 213 Lower Ie stourethrocde } . stage . stage . Stage Enterocele Recto descent of cervix 0 Quantitative) No prolapse : Ii All I points stage III into vagina upto introits Hymen within 1cm of -1 and + Hymen 1) lowest point 71cm below hymen but not complete prolapse : complete prolapse stage II : . above 71cm point lowest : I btw . descent of cervix : ( Pelvic organ prolapse urethra : POPQ staging . Cystocele : to poster lateral cervix From periosteum of 523,4 vertebrae : - pudenda 1 Chronic pubic from c) Uterine descent perineal tear Others . - Large baby - - labor forming perineal body ③ Urogenital diaphragm at places B) posterior vaginal wall multiparty - - - : Prolonged - ③ - Menopause - is condensed A) Anterior vaginal wall weakness of supports Congenital - organ from Classification . Atonicity ① of ② Perineal muscles ligaments : Transverse cervical - . ① Levator ani muscle d) Pubocervical ligament to side - . form to for uterus mesentery as Inferior Tier ① Dericervical ring ② Endo pelvic fascia ③ Broad ligaments - ) middle Tier strongest support descent of cervix outside introits or vault aversion Providential Entire uterus outside introits . pressure bronchitis Mx : : .NU/liparous: Abdominal sling Sx : . pregnancy . post Natal Ring pessary upto : 16 weeks 1) Vaginal symptoms - Sensation of bulge - - - Pressure or profusion 2) Urinary symptoms : frequency 4 , surgery . Young . woman urgency - : straining during defecation - 4) Dyspareunia - Indications : Procedure with 2nd I 3rd 1) Anterior : Colporrhaphy degree uterine - tip of ligament amputated in cervix covered front of cervix by vaginal flap 6) using stormdorff sutures 7) Cold operineorrhaphy is done complications : ① Haemorrhage ② Cervical incompetence ③ Cervical stenosis ④ Cervical dystonia prolapse ⑤ Infertility ⑥ Premature rupture - : posterior Colporrhaphy Manchester operation sling surgeries or : : static , , isthmus , Closed loop anterior sling , Tape anchored to anti abdominal wall 4 ant . aspect of isthumus ② of membranes : ② Purandara 's CerviCOPEXU : Dynamic Khanna 's - . uterine prolapse Closed loop posterior sling Tape anchored to sacral promontory 4 posterior aspect of 3) Amputation of cervix 5) Posterior : ① Shirodkar's sling done Macken rodt 's vaginal wall prolapse Ant.CO/porrhaphy sling surgeries : prolapse 2) Cervix dilated 4) Dlication of . vaginal surgery (Fertility sparing ) family complete vaginal Hysterectomy with Ant ¢ posterior colporrhaphy ( pelvic floor repair) operation : young patients Conservative Women 740 years . Manchester ( Fothergill ) Ant Floor exercises required Posterior vaginal wall - - symptoms ( in Redocele ) : if ( 140 years) incomplete emptying - . & Heaviness Excessive whitish discharge (due to venous congestion ) Blood stained discharge due to deulbitous ulcer independent part 3) Bowel Ring pessary ¢ pelvic ' sling Tape anchored : static open neutral , to A9S ④ Virkud 's composite sling : , sting & anterior aspect of islhumus static + dynamic open , , Anterior + posterior sling . Male infertility ' failure to conceive primary : . previous : Aetiology . 1) Genetic pregnancy , but failure sex . to subsequently conceive [ - Irrespective : . Abnormal y chromosome - regular unprotected of year one conceived Never Secondary . after Kline fetter 's , Investigations : 1) syndrome previous pregnancy ] of of outcome Routine Blood sugar : CBC 2) Diordels - spermatogenesis of Hormonal , Testicular : a) Varicocele - - absence trauma , masturbation & : ideal time - 4) Disorders : - Kartagener syndrome limmotile - Sperm 5) sexual dysfunction : - 6) 7) Zonapelkida binding USG for potency of - drugs smoking , , D) chromosome and genetic analysis : Correct For - , weight Impotence Psychosexual help - loss sildehafil 50.100mg 11 hr before sexual activity ) - thyroid disorders Retrograde ejaculation . - . . phenyl ephrine ( improve tone of Hypogonadotrophk Hypogonadism sphincter) Inj HM9 Dulsatile GnRH . - Treat infections - to Advice - - - - - Surgeries . Astaxanthin Hypogonadism (testicular failure) - IUI IUI - - coenzyme Q multivitamins - Transurethral led E) resection of For obstruction of ejaculatory duds - improves levocarnitine Reproductive technology : IUI , IVFIICSI Semen Exam Not mat v ✓ . IUI 3- E cycles v ( with ovarian stimulation with Abnormal omiphene citrate) Failed IUI v ✓ IVF ICSI t v v If Count more investigations than 10 motile sperms correction of It count 05×106 motile sperms v fails I IVI - donor Adoption abnormality vaslepididymis semen Donor Adoption : Vasovdsotomylvasoepididymostomy - - IVFIICSI - For vaniocele - zinc Assisted Clomiphene citrate Hypergonadotropin ic , Antioxidants - . stop smoking alcohol Medical Mx ' : Inj HCGSOOOIU - - - . alcohol Control sugar - vas a) Sperm function - Exercise - Testosterone , prolactin LH , scrotal USG 8) Vasogram Improve general health - , premature Lifestyle modification - FSH : biopsy 6) Trans rectal Chronic illness - of abstinence Fructose content in seminal fluid 5) Testicular 4 Fusion defect Psychological .MX . 4) 7) 8) Substance abuse days cilia) acrosome defect Impotence - 3- 5 frequency low coital - After electro ejaculation oocyte fusion defect - - , inflammatory blockage , 3) Hormonal evaluation Ivesiculah fluid of sperm ( silicone polyurethane ) vibratory stimulation 4 Penile Radiate sterile container collection in Collection condom , congenital Semen analysis sample - Cryptochordism orchitislmumps.TN Drugs ( cimelidine spironolactone ) 4 - : Urine routine , Absent germ cells - - 3) Duct disorders Hypothyroidism Hyperproladinemia , Kallman n syndrome - - TSH Hypothalamic pituitary : . aleality Aetiology - Female infertility : ② Tubal ① Ovarian peritoneal Anovulation it Diminished iil ③ 4 tuba , obstruction due to ovarian ' Reservation mature ovarian Failure i )pID iiilufealpha Defect irllutenisedunruptored this NTUbd V follicle on ) Adhesions ⑤ vaginal Stenosis iilprolapse ilvaginal Atresia iiilscantdmuw.li) Transverse a) Polyps ( Asherman Endometriosis " ikervicdl 1) fibroids 3) Sisnechiae ii )tB ④ Cervical Uterine syndrome) ivkerviatis a) uterine Hypoplasia g)septalelpsicornuale uterus * body temp Tests for Tubal - potency : - ( forth) - Sr g) - , uterine recent ovulation 3) FSH serum smoking Infections Douglas on TVs are . serum Measure on SIS ASH on ' I cycle days day . + ovaries not well on days 5-9 10 I Back to normal Elevated . : 100mg Clomiphenecitratelday 2) Administer 4) Hyskrosalpingo Contrast nography 5) Hysleroscopy SRLH Cigarette of Clomiphene citrate Challenge Test 4) laparoscopy viiltransvaginal USG ( for follicular study ) t Normal function functioning 5) Laparoscopy 6) Falloscoby Direct method * of 4 Free fluid in touch sonographycsis) progesterone Addison 's disease - - Features 2) HS4 3) Hypothyroidism) thyroiditis - Hyproladinemia 1) Measure saline infusion - srestradiol - E- Galadosemia chemo tradition cervical mucus iffndometrial biopsy estimation II. Ovarian failure anomalies iiilcervi.ca/mucusstudy2IHysIerosalpingograph YLHSGI ivlvaginal cytology vilhlormone - Detects fibroid , polyps . - PCOS - DUSG 1) Rubin 's test 1) Menstrual History ii ) Basal Hypothalamic pituitary failure I. * collapsed follicle Diagnosing Ovulation Indirect methods - I Ovarian failure causes vaginal septum ↳ Anti sperm antibody in Investigations - Anovuldtion - Laparoscopy g) salpingoscobll Test for Ovarian Reserve - FSH 1) Day 's Basal 2) Basal Estradiol [760 pglml phase > in early follicular Reproductive aging & Hastened cykdev) 3) Anti.mu/lerianHormone 4) Inhibits Bt with tin number of oocytes 5) Clomiphene citrate Challenge 6) Test USG - Antral Follicle count Rt • : therapeutic DAnovulalion.fuboblastysx.tt Adhesiolysis Ovulation Induction Hysleroscopy agents : - Clomiphen @ Citrate 150.250mg Iday ) - - - - Fimbrioplasty quality improvement by oestrogen HMG.MG - acetyl eystein d) Diminished - - - reserve iii. steroids Case DHEA 25mg tid IVF 2) Control of sugar in DM 3) Correction of thyroid disorders Reversal of tubal ligation ' stop smoking alcohol improves sperm corneal connotation penetration : weight loss - , ii)N Tubotubal anastomosis Iv - 1) Lifestyle modification Salpingostomy , - : - letrozole Ancestral - General measures itcervicalmucus 4 of endometriosis in of anti sperm antibodies 4) stress relief 5) Appropriate therapy of infections if present R , NF with donor oocyte ' Unexplained infertility - super ovulation ✓ -1 Intrauterine insemination Fails In vitro fertilisation ' In case of Normal ovaries & Absent Uterus Indications for therapeutic Hysleroscopy 1) polyps G fibroids ( Hysleroscopicpolypectomylmyomectomy) a) Intrauterine adhesions 3) Lateral wall metroplasty for 4) Septum resections : surrogacy : 1- shaped uterus Endometriosis Definition ' It : is other defined functional presence of normal endometrial cavity than as endometrial mucosa (glands & stromal - is Extremely rare - Genetic - a hormone proliferative menarche before susceptibility theories - sites : . Endometriosis in seen Isi dependent disease of childbearing period and disappears after cases . menopause 1) . Pelvic . 4) Ovarian 5) Chocolate cyst of ovary 6) Appendix pelvic lymph nodes scar endometriosis 1) Metastatic Lungs : Sampson 's theory of Retrograde menstruation ( most accepted ) a) Coelomic metaplasia Ivan off & Meyer 3) Haematogenous spread a) Lymphatic spread that ban 's theory) 5) Direct implantation , - , : . Investigations 1) Laparoscopy - : Infertility - Dyschezia - Pain - on Cyclical - . findings Mx ( pain on micturition Haematite 'd mostly edometriosis in seen iii) Matchstick of pouch of douglas lif frequency involved ) Bladder burnt spots in Blueberry lesion v ) Red 1 Purple raspberry lesion vi) sub ovarian adhesions vii) sub peritoneal defects ( Allen Master syndrome) defecation ) & Teed cysts iit powder bum spots 21 USG trans vaginal ) 3) CT 4) CA 125 IMRI - Nonspecific marker : symptomatic Asymptomatic medical : symptomatic relief from pain dysmenorrhoed , - Observe 6-8 months t size of lesions for infertility it pills 0C ii ) 1) Minimal Invasive 2 tabs X 6-9 months Medroxy progesterone - acetate ( 10 mgtid ) 110 mg Hay )X Dihydrog estrone - Destruction - progesterone oral surgery . 1) Pseudo pregnancy regimen V Investigate of endometriosis & staging : it chocolate bdominal pain and back Dain 4-Jeep dyspareunia site choice ablation of removal menorrhagia & premenstrual spotting Pelvic pain = Investigation of biopsy surgically treat endometriosis by Dysmenorrhoea - : Take Asymptomatic - : Detects C1F : - Endometriosis 2) Pouch of Douglas 3) Utero sacral ligament . 1) . locations in . Aetiology : . implanted abnormally Xo g months Excision - - f- a month Iii Im progesterone medroxy progesterone 150mg in Levonorgestrel releasing IUD d) Pseudo menopause regimen Danazol 400mg in 4 divided - doses X 6- a months ( Rarely used ) - - - Gastrinone 25mg g) medical castration - - : twice a week × 6- a months GnRH analogue CMK ) leuprolid@3.ls mg Im Nata reline intra nasal 200mg monthly daily X 6 month X 6 months a) Dienogest oral semisynthetic active steroidal progesterone : 1 Laser ablation pain relief LUNA a) Laparotomy : - by cautery cyst presacralneurectomy.fr - at 3 months interval - laparoscopy Adhesions is - ) of : Hysterectomy Excision with bk salpinooophoredomy of scar endometriosis Fibroid v ✓ cervical Uterine t 1 Iv v - u Interstitial subgenus sub mucous - Intramural ) ( most sessile - - common - Anterior posterior Central lateral pedunullated - Effects ' . Incidence 20% : Etiology C1F : - Estrogen dependant tumor Multiparty - ( Infertility - fibroid are - - - infertile 4 causes Infertile women prone - Obesity - Deletions of chromosome - 7 - - * ' smoking protective is Investigations Blood group . USGCIOC) - Doppler USG - . Blood sugar Hyperechoic Determine : → ECG , , , chest hypo echoic Calcification , x ray etc . preterm labor IUGR . . prolonged Iobstructed labor - APHEIPPH Infertility Lump in pressure abdomen symptoms On examination cervix , urinary or firm to hard enlarged uterus with moves dysuria - movement of mass retention 42-14 wks felt or more ) per abdomen . . mass Anechoict Necrosis vanity fibroid differentiate Saline infusion adenomyosis from . ( Blood flow surrounds fibroid , but diffuses through adenomyosis) . nography MR1 1CT . . , , - ' - concentric solid - - ' malpresentations : CBC , . Dysmenorrhoea - to develop fibroids ) Asymptomatic menorrhagia metorrhagia : pregnancy Abortions - . on Hyskroscopy - Diagnostic as well therapeutic as . laparoscopy RI Fibroid ✓ v symptomatic Asymptomatic v w Surgery Regular supervision ↳ months interval ) - - - • ✓ Size stationary t follow - - surgery sizes Rwks Pedunullatd causing hydrometer Symptoms t young Myomectomy ① vaginal : Removal Uterine Family complete Hysterectomy tnyomedomy of fibroid leaving uterus behind u r u . ③ Laparoscopic ② Hysleroscopic + + sub mucous fibroids artery embolisation appear surgery up v Old size tses - For v ✓ fubmucous fibroids not - removable easily by vaginal Implications Route : ① Cervical trauma ④ Uterine adhesions ② thermal injury ③ Bleeding ⑤ Infection ⑥ Failure For a) Peduncle lated fibroid b) sub serous ( not 710cm , not 74in number) preoperative therapeutic Pelvic pain Acute pelvic pain Causes : Obstetric - Abortions - , septic abortion degeneration Red - of fibroid Twisted ovarian cyst Acute - - Molar pregnancy - - Urinary retention Appendicitis Abdominal TB - DID - Endometriosis - syndrome Ovarian Hyperstimulation Ovarian Acute cystitis - mittelschmerz - - Hydraamnios others : Dysmenorrhoea - Ectopic pregnancy - - Gynaecological UT1 - tumors Abrupt'o placenta @ - Chronic pelvic pain Investigations : Aetiology US4 Doppler USG - - 1) Gynaecological causes : mostly Organic Ovaries i - - - ) Iii Tubal - - Adhesions Residual Ovarian syndrome - - parameter 'tis in Uterine MRI Hysterosoopy Diagnostic laparoscopy - fibroids pyelography Intravenous - Adhesions of joints CECT - Tumors colonoscopy Radiography - Chronic P1D - urine tests - Endometriosis pelvic congestion For Conscious - Pain mapping - Laparoscopy interaction Adenomyosis various fixed retro rated uterus pyometra 4 Pelvic TB a) Functional - - and adhesions . - medical - causes : ① NSAIDs ② progesterone therapy : Congestive dysmenorrhoea ③ mittelschmerz SSRI Cpps pelvic varicose veins - - Adjuvant therapy fluoxetine gynaecological causes ! - - - - - - - - - Intestinal TB surgeries Diverticulitis Irritable bowel ① Ca on touching organs song Hay ① Acupuncture : Endometriosis in 1 day wave diathermy presacral Rectum ( LUNA) utero sacral Nerve ablation Laparoscopic > ② Drugs & doses : syndrome Intestinal obstruction ( chronic) patient with 10 -60mg sertraline ② Short g) Non t Mx - - under LA side effects : prolapse , Bladder dysfunction Neuredomy ureteric colic Nerve Joint entrapment - static magnetic therapy stimulation pains - has been for a week helpful in or Transcutaneous some cases nerve . for varicosity of pelvic veins : Embolisation Sderotnerapy 151 ethanol amine . mdleate) Cervical cancer symptoms Risk factors : Young ① at 1st intercourse age ② Multiple sex ③ cigarette smoking 416 years) partners vaginal discomfort malodorous vaginal discharge - ④ Race - ⑨ High parity ⑥ HPV infection ⑦ HN pelvic pain - Dysuria - frequency : Cachexia Anaemia - - , urgency rectum invaded) involved pelvic wall - ⑨ Low socioeconomic status A . constipation ( if - ⑧ Immunosuppression vaginal bleeding Abnormal - leg edema , pain , Hydronephrosis Investigations ' - .MX Pre clinical Pap - stage ( Exfoliate cytology) smear ① stage IA1 HPV DNA test - - : : testing Colposcopy and DNA Diagnostic cone Biopsy - young patient therapeutic cauterisation old patient simple Extra facial Hysterectomy : ② Stage IA2 IB , Clinical stage - Punch - Late ca & Biopsy ③ Stage IB - R, Meigs Obayashi Hysterectomy) operable by Radiotherapy ( External beam RT to pelvis & Brachytherapy ) - ray to rule out pulmonary mats Abdominal 91mm to rule out liver mets Chest - - x Radionuclide - Addition of Cisplatin 40mg weekly improves : . IA Can be - radio sensitivity . Depth of ¥§gi; II to or IA . - - - : are all Radio sensitive : Invasion , depth Max of invasion ( 5mm ⑥ Poorly differentiated tumor 13mm Invasion 3- 5 mm in depth Neo adjuvant Greatest dimension . . beyond uterus to , not extend but does to lower 43 of vagina upper 213 vagina without parametric involvement . size gem size 7,4cm Involvement of Involves lower Extension to : IIB : parametric m but 113 of pelvic not upto pelvic wall . vagina but not pelvic wall wall or Hydronephrosis IN on functioning kidney ( not IIc - : Involvement III ; Pelvic of LN Para aortic pelvic metastasis or only LN metastasis IB : : spread to adjacent pelvic organs spread to distant organs . any other known due to 14 paraorlic lymph nodes II IIA chemotherapy : ① paclitaxel 90mg -11ns Ifosfamide 1000mg -1 Masha 400mg weekly for 3 cycles II II A post op RT: reseated margin ③ Evidence of lymph oracular invasion 74cm limited IA2 . ② Positive pelvic wall : : : invades IA1 IB I invasion 75mm Size Carcinoma : : sgifgelffnfcm.in IB1 - ① Positive LN for metastasis IA2 : I : IA1 IB stage indication of strictly confined to cervix diagnosed only microscopically carcinoma I 89 scanning FIGO staging 12018) - Hysterectomy USG - . I : Not cytoscopy ¢ proctoscopy - - - Colposcopy - Wertheim 's cervix Hysteroscopy - - on RFT 4 left - . ulcer or CBC - : (aka : growth from IA , . cause ) ② cisplatin 50mg weekly Endometrial Cancer Risk Factors : Estrogen dependent Postmenopausal Bleed DIDS cancer - ( Anovulationt Hyperestrogen Ism) ① PCOS cell tumor of ovary ( estrogen menarche and late menopause ② Granulosa ③ Early ④ Age , Uterus : C1F secreting) I so years ⑤ Multiparty - ⑥ Tamoxifen therapy ⑦ Unopposed estrogen therapy in HRT ⑧ Atypical endometrial Hyperplasia ⑨ Lynch a syndrome - Atrophic endometrium - postmenopausal bleeding senile endometntis HRT - perimenopausalpolymenorrhag.io Offensive watery discharge Endometrial Hyperplasia Endometrial cancer - - Simpson 's pain Endometrial polyp - Uterine sarcoma - fibroids - . . Cervix Cancer - Investigations : . Cerviatis - ① Fractional ⑦ Pre op evaluation curettage ② DEI C - ③ Endometrial biopsy - ④ Hysterosoopy ⑤ Transvagindl Ultrasound thickened Endometrium Hyperechoic endometrium with CBC , FBS chest - x , - . RFT LFT , rsedrasalan.ly on Vagina ray - EC9 - . irregular polyps . - - Erosion - Ovary Atrophy Cancer - Tumors Cancer , outline . Doppler Fallopian rare) tube ca( very ⑥ CTIMRI ( if needed) My : . Staging - : Total Abdominal Hysterectomy with BIL salpingo-oopherectomy .tn Tumor confined to uterus → : + IA - IB - No : 142 myometn.at invasion or vaginal cuff radiation Radiotherapy the myometn.at invasion : - 9%3%8%1 : External beam radiation modified Radical Hysterectomy tBKsalpingo-oopheredomyt.tt Cervical stromal invasion but not beyond uterus IN dissection RTC 4500-500044) External > : . I TIA - IIB - - . Beam -1 : Invades : Vaginal lparametn.at aerosol or adnexa invasion IIC > IICI > IC2 : : pelvic LN involved Para aortic LN involved I - - s IIA : IB : Invasion of bladder 1 bowel Distant De bulking surgery followed by Radiotherapy ( External Beam) mucosa metastasis . Chemotherapy Advanced and Hormonal therapy recurrent cases or Chemotherapy Agents - - - - - Cisplatin Carbo plain Cyclophosphamide paclitaxel Adriamycin is used in . Hormonal - - - therapy progestins GnRH analogues Aromatase inhibitors