Dallas ISD - Dallas, TX SCIENCE AN INTRODUCTION TO NEUROSCIENCE 2023-2024 The vision of the United States Academic Decathlon® is to provide students the opportunity to excel academically through team competition. Toll Free: 866-511-USAD (8723) • Direct: 712-326-9589 • Fax: 712-366-3701 • Email: info@usad.org • Website: www.usad.org This material may not be reproduced or transmitted, in whole or in part, by any means, including but not limited to photocopy, print, electronic, or internet display (public or private sites) or downloading, without prior written permission from USAD. Violators may be prosecuted. Copyright ® 2023 by United States Academic Decathlon®. All rights reserved. Table of Contents SECTION I: CELLS AND THE ANATOMY OF THE BRAIN . . . . . . . . . . . . . . . . . . . 3 Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Exercises . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 SECTION III: SENSORY AND MOTOR SYSTEMS . . . . . . . . . . . . . . . . . . . . . . . . 12 Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Exercises . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 SECTION IV: SYNAPTIC PLASTICITY AND MEMORY . . . . . . . . . . . . . . . . . . . . 18 Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 Exercises . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 SECTION V: TECHNOLOGY AND NEUROSCIENCE . . . . . . . . . . . . . . . . . . . . . . 23 Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Exercises . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 ANSWER KEYS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Section I Answer Key . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Section II Answer Key . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Section III Answer Key . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 Section IV Answer Key . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 Section V Answer Key . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 2023–2024 Science Student Exercise Book 2 Dallas ISD - Dallas, TX SECTION II: NEURAL COMMUNICATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Exercises . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Section I Cells and the Anatomy of the Brain OVERVIEW Neuroscience is the study of the nervous system, and the main role of the nervous system is communication. This scientific field examines the way our nerves communicate to our brains, our brains to our bodies, and our bodies to our brains. The nervous system is not only responsible for our thoughts, it also controls body functions like breathing. Studying the nervous system helps us understand how the whole human body works. To begin to understand neuroscience, we’ll study the cells and systems that make up the nervous system. Cells of the Nervous System: Neurons and Glial Cells ● The soma is the cell body where the nucleus is typically found and where DNA is stored. ● The dendrites bring information to the cell. The dendrites bring in input (information) from many points of contact, including other neurons. ● The axon sends signals out from the neuron, often to other regions of the brain or body. The axon looks similar to a wire and ends at the axon terminal, where the neuron releases its signal. That signal is either an electrical signal, called an action potential, or a chemical signal, called a neurotransmitter. Information passes between neurons at a synapse. Signals float across the synaptic cleft. They bind to receptors that receive the signal. Cells in the nervous system that are not neurons are called glia, or glial cells. There are a variety of glial cell types, including these: ● Oligodendrocytes and Schwann cells form the myelin sheath around many neuronal axons. Myelin is a fatty substance that insulates axons. ● Astrocytes help balance the chemical makeup of the fluid that’s between nervous system cells. Astrocytes contribute to the blood brain barrier by wrapping around blood vessels. The blood brain barrier keeps unwelcome substances in the bloodstream from entering the brain. ● Microglia help prevent toxins from harming neurons in the brain. Anatomy of the Central Nervous System The brain and spinal cord make up the central nervous system. The bones of the skull and the vertebrae protect but do not touch the nervous system. The brain is made up of several parts: ● The cerebrum is the largest part of the brain. It has a left and a right cerebral hemisphere. The cerebral cortex is the outer layer of the cerebrum and is where most of the brain’s neurons are found. Each hemisphere of the cerebrum is divided into four lobes: ♦ The frontal lobe is behind the forehead. This area helps us with tasks including decision-making and logical problem-solving. 2023–2024 Science Student Exercise Book 3 Dallas ISD - Dallas, TX The most well-known cell type in the nervous system is the neuron, or nerve cell. Neurons are at the center of how our bodies receive, process, and transfer information. They are made up of three main parts: ♦ ♦ ♦ The parietal lobe is located just behind the frontal lobe. It helps process the sense of touch. The occipital lobe is at the back of the cerebrum. It helps us analyze visual information. The temporal lobe is located on the sides of the head. It helps process sound and is also key to object recognition. ● The cerebellum sits underneath the cerebrum and helps with learning movement and making coordinated movements. ● The brainstem connects the brain to the spinal cord and helps control involuntary functions such as breathing. ● There are many other regions of the brain, called subcortical structures. The amygdala is found in the temporal lobe and helps control emotions, like fear and arousal. The hippocampus aids with long-term memory and spatial navigation. These are two of many such structures in the brain. Aside from the brain, the spinal cord is the other main component of the central nervous system. The spinal cord is positioned within the vertebrae (or back bones) that make up the spine. The spinal cord transfers information between the brain and the body. This includes information regarding touch, pain, temperature, and movement. The Peripheral Nervous System ● The somatic nervous system is made up of the axons leaving and entering the spinal cord. They bring information to and from the tissues of our bodies. This is what controls the conscious movement of body parts. ● The autonomic nervous system controls involuntary responses that occur without us specifically thinking about them or consciously trying to do them. Specifically, it regulates the functions of our internal organs and smooth muscle—like the muscle in the heart. The sympathetic division of the autonomic nervous system is responsible for the body’s “fight or flight” response. The parasympathetic division of the autonomic nervous system is responsible for “rest and digest.” 2023–2024 Science Student Exercise Book 4 Dallas ISD - Dallas, TX The peripheral nervous system is what helps our brains respond to the physical environment around the body. It consists of two systems: EXERCISES TRUTH OR REPAIR DIRECTIONS: Read each of the following statements and determine whether it is true or false. If the sentence is false, cross out the incorrect part of the sentence and write the correction in the space provided. 1. A typical feature of a neuron is a long axon. ___________________________________________________________________________________ 2. The largest part of the brain is called the cerebellum. ___________________________________________________________________________________ 4. Dendrites often have many branches, like a tree. ___________________________________________________________________________________ SCIENCE 5. Cells in the nervous system that aren’t neurons are called glia, or glial cells. ___________________________________________________________________________________ 6. The area where one neuron communicates with another is called an axon. AN INTRODUCTION TO NEUROSCIENCE ___________________________________________________________________________________ 7. The peripheral nervous system delivers information from the body to the brain, and from the brain to the body. ___________________________________________________________________________________ 2023-2024 8. Microglia help balance the chemical makeup of the fluid in between cells of the nervous system. ___________________________________________________________________________________ The vision of the United States Academic Decathlon® is to provide students the opportunity to excel academically through team competition. Toll Free: is 866-511-USAD (8723) • Fax: 712-366-3701 • Email: info@usad.org • Website: www.usad.org brainstem located at the• Direct: back712-326-9589 of the brain. 9. The This material may not be reproduced or transmitted, in whole or in part, by any means, including but not limited to photocopy, print, electronic, or internet display (public or private sites) ___________________________________________________________________________________ or downloading, without prior written permission from USAD. Violators may be prosecuted. Copyright 2023 by United States Academic Decathlon . All rights reserved. ® ® 10. The cerebrum contains two equal parts, the top and the bottom hemispheres. ___________________________________________________________________________________ 2023–2024 Science Student Exercise Book 5 Dallas ISD - Dallas, TX 3. The brain and brainstem make up the central nervous system. ___________________________________________________________________________________ VOCAB MATCH-UP DIRECTIONS: Match each vocabulary term to its corresponding definition by writing the appropriate letter in the space provided. Terms A. Parasympathetic division B. Frontal lobe C. Sympathetic division D. Subcortical structures E. Central nervous system F. Peripheral nervous system G. Cerebellum H. Cerebrum I. Parietal lobe J. Spinal cord 1. __________ This region of the brain is primarily concerned with the motor system and movement. 2. __________ Located below the brainstem, this is a main structure of the central nervous system. SCIENCE 3. __________ This part of the brain contains two hemispheres, left and right. 4. __________ This part of the nervous system is responsible for the “fight or flight” response. AN INTRODUCTION TO NEUROSCIENCE 5. __________ This part of the nervous system is responsible for the “rest and digest” response. 6. __________ This area of the cerebrum helps with tasks like problem-solving and decision-making. 2023-2024 7. __________ This area of the cerebrum processes the sense of touch from the body. 8. __________ This helps the brain stay in touch with the physical environment, sending information fromStates different of® the bodystudents back the to opportunity the brain. The vision of the United Academicareas Decathlon is to provide to excel academically through team competition. Toll Free: 866-511-USAD (8723) • Direct: 712-326-9589 • Fax: 712-366-3701 • Email: info@usad.org • Website: www.usad.org This material may not be reproduced or transmitted, in whole or in part, by any means, including but not limited to photocopy, print, electronic, or internet display (public or private sites) 2023 by United States Academic All rights reserved. or downloading, without prioris written permission from USAD. Violators be prosecuted.below Copyright the 9. __________ This found underneath themaysurface cerebral cortexDecathlon and .includes the amygdala, ® ® hippocampus, and thalamus. 10. __________ This part of the nervous system is encased in bone; it is made up of the brain and spinal cord. 2023–2024 Science Student Exercise Book 6 Dallas ISD - Dallas, TX Definitions Section II Neural Communication OVERVIEW One of the main roles of the nervous system is communication. Neurons can send electrical signals very long distances across the body, which is how they communicate to our brains and our bodies. Ions found in the nervous system allow neurons to communicate. Ions can have a positive or negative electrical charge. The electrical charge of a cell compared to what is outside its membrane is called its membrane potential. A neuron can be in a resting or excited state depending on which ions are either inside or outside the cell. The Resting Membrane Potential ● cytosol, the fluid inside the cell, which is mostly water ● the extracellular fluid, the fluid outside the cell, which is mostly water the neuronal membrane, which separates the fluid inside the cell from the fluid outside the cell ● There are charged ions in the water of the cytosol and extracellular fluid. This difference in concentration of the fluids is the key to neuronal communication. Movement of an ion across the membrane occurs in two possible ways: ● Passive transport occurs when an ion moves from one area to another naturally, requiring no energy from the neuron. This can occur due to ionic concentration (diffusion) or an electrical charge (potential). ● Active transport occurs when an ion is forced to go against a concentration gradient or electrical potential to cross a membrane. The main example of active transport in a neuron is when ions move from one side of the membrane to the other via a pump. The Action Potential The action potential is the electrical potential across the neuronal membrane when the cell is active. The action potential creates a sudden change in the membrane potential. Ions can flow in and out of the cell when this occurs. Action potentials are also referred to as spikes or nerve impulses. Action potentials can be triggered by many things. For instance, when exposed to heat or cold, the neurons in the skin may fire action potentials. Action potentials travel down the neuron’s long axon very quickly. Once the action potential reaches the bottom of the axon (the terminal), synaptic transmission occurs—this is when neurons transfer signals. The neuron releasing the signal is called the presynaptic neuron. The neuron receiving the signal is called the postsynaptic neuron. Most neurons transform the action potential from an electrical to a chemical signal to move across the synapse. These chemicals are called neurotransmitters. 2023–2024 Science Student Exercise Book 7 Dallas ISD - Dallas, TX If a neuron that can send electrical signals is not doing so, the cell is at rest. The electrical charge inside the neuron in this state is called the resting membrane potential. The three things that dictate the resting potential of a neuron are: Neuropharmacology Dallas ISD - Dallas, TX Scientists and doctors study neurotransmitter release for many reasons but often do so because understanding how the brain works, and how medication can alter brain function, can help them prescribe the right medicine. Many of the drugs that alter the brain’s function and its behavior (such as serotonin selective reuptake inhibitors or SSRIs) work by altering the function of the neurotransmitter receptors in our nervous system. 2023–2024 Science Student Exercise Book 8 EXERCISES CROSSWORD PUZZLE SCIENCE AN INTRODUCTION TO NEUROSCIENCE 2023-2024 Across Down 4. The neuron that receives a signal from another 1. W hen an ion moves from one area to another neuron naturally, requiring no energy 5. ConductsThe electrical impulses or action potentials 2. The neuron thatacademically releasesthrough a signal to another neuron ® vision of the United States Academic Decathlon is to provide students the opportunity to excel team competition. Free:body 866-511-USAD (8723) • Direct: 712-326-9589 • Fax: 712-366-3701 • Email:the info@usad.org • Website: www.usad.org in and out of away from theTollcell 3. C ontrols movement of substances This material may not be reproduced or transmitted, ininformation whole or in part, by anyfrom means, including butthe not limited to photocopy, print, electronic, or internet display (public or private sites) 7. A nerve impulse used to transmit neuron or downloading, without prior written permission from USAD. Violators may be prosecuted. Copyright 2023 by United States Academic Decathlon . All rights reserved. one place to another 6. W hen an ion is forced to go against a concentration 8. A chemical messenger that carries information from gradient or electrical potential to cross a membrane one neuron to the next target cell 9. Fluid inside of a cell body 10. A n atom or molecule with a net positive or negative electrical charge ® 2023–2024 Science Student Exercise Book 9 ® Dallas ISD - Dallas, TX DIRECTIONS: Complete the crossword puzzle below using terms you learned in section II of your resource guide. Good luck! FILL IN THE BLANKS DIRECTIONS: Using the word bank as a reference, fill in the missing words. Some words will become plural in construction, and some may be used more than once. action potential neurotransmitter axon neuron chemical postsynaptic electrical presynaptic nerve synaptic transmission ____________ can send ____________ signals very long distances across the body. These signals are called ____________. They are key to communication between ____________, the brain, and the body. SCIENCE Action potentials travel down the neuron’s long ____________ very quickly. Once the action potential reaches the bottom, ____________ occurs—this is when neurons transfer signals. The neuron releasing the signal is called the ____________ neuron. The neuron receiving the signal is called the ____________ neuron. AN INTRODUCTION TO NEUROSCIENCE To send a signal to the next neuron, most cells translate the action potential from a(n) ____________ signal into a(n) ____________ signal that moves across the space between cells. The chemicals involved are called ____________, which are various in kind. 2023-2024 The vision of the United States Academic Decathlon® is to provide students the opportunity to excel academically through team competition. Toll Free: 866-511-USAD (8723) • Direct: 712-326-9589 • Fax: 712-366-3701 • Email: info@usad.org • Website: www.usad.org This material may not be reproduced or transmitted, in whole or in part, by any means, including but not limited to photocopy, print, electronic, or internet display (public or private sites) or downloading, without prior written permission from USAD. Violators may be prosecuted. Copyright ® 2023 by United States Academic Decathlon®. All rights reserved. 2023–2024 Science Student Exercise Book 10 Dallas ISD - Dallas, TX Word Bank SHORT-ANSWER QUESTIONS DIRECTIONS: In one to three sentences per question, answer the following questions. 1. Describe what an action potential is and how it occurs. _________________________________________________________________________________ _________________________________________________________________________________ _________________________________________________________________________________ 2. Describe at least two examples of stimuli in the environment that might trigger sensory neurons. _________________________________________________________________________________ _________________________________________________________________________________ 3. Describe the process of diffusion and how it relates to ions. SCIENCE _________________________________________________________________________________ _________________________________________________________________________________ _________________________________________________________________________________ AN INTRODUCTION TO NEUROSCIENCE 4. What is the resting membrane potential? _________________________________________________________________________________ 2023-2024 _________________________________________________________________________________ _________________________________________________________________________________ 5. Why might a doctor or scientist want to study or understand neurotransmitter release? The vision of the United States Academic Decathlon is to provide students the opportunity to excel academically through team competition. _________________________________________________________________________________ Toll Free: 866-511-USAD (8723) • Direct: 712-326-9589 • Fax: 712-366-3701 • Email: info@usad.org • Website: www.usad.org ® _________________________________________________________________________________ This material may not be reproduced or transmitted, in whole or in part, by any means, including but not limited to photocopy, print, electronic, or internet display (public or private sites) or downloading, without prior written permission from USAD. Violators may be prosecuted. Copyright ® 2023 by United States Academic Decathlon®. All rights reserved. _________________________________________________________________________________ 2023–2024 Science Student Exercise Book 11 Dallas ISD - Dallas, TX _________________________________________________________________________________ Section III Sensory and Motor Systems OVERVIEW Sensory systems convert external stimuli into chemical and electrical signals that the nervous system processes to communicate to the brain and body. When a sensory receptor is activated by an external stimulus, it generally fires an action potential or releases a chemical neurotransmitter. This causes the next neuron in the pathway to do the same. Said another way, the sensory system is in charge of transducing, or converting, environmental signals into electrochemical signals for neurons to process. The electrical signal is an action potential. The chemical signal is a neurotransmitter. We only become aware of an external stimulus (like a scent) when sensory information reaches the cerebral cortex. The motor system is similar to sensory systems, but the neural signal travels in the opposite direction—from the brain out to the body. The Visual System ● The visual system begins with the eye. The transduction of light into an electrochemical signal takes place in the retina with the photoreceptor neurons. ● Rods and cones are the two types of photoreceptor cells. Cones do the bulk of transduction work for environments with bright light, while rods handle environments with low levels of light. ● The primary visual cortex (V1) is responsible for the initial processing of visual input. Information about color, shape, and form is sent from V1 to other areas of the cortex. These processes are how we visually recognize objects, faces, symbols, colors, and text. The Auditory System ● The auditory system begins with the ear. Pressure changes in the air are the sources of sound. These can vary in frequency, which changes the pitch or tone of a sound. They can also vary in intensity, which adjusts loudness or volume. These pressure changes are encoded by the brain and enable us to hear. ● Sound waves bounce off the folds of the external ear folds (or pinnae) and travel down the auditory canal. In the canal, they vibrate the ear drum or tympanic membrane. ● The ear drum’s movements change the pressure waves of the air into physical movements in the middle ear. These movements are transmitted through the middle ear by ossicles, which are the tiniest bones in the human body. The three ossicles in the middle ear take the physical movement of the ear drum and transport it to the fluid of the inner ear. ● The inner ear contains the cochlea, which is in charge of transducing sound. The organ of Corti is inside the cochlea. This is where the pressure wave in the fluid is converted into an electrochemical 2023–2024 Science Student Exercise Book 12 Dallas ISD - Dallas, TX Smell, taste, sight, touch, and hearing are senses that tell us about the world around us and often help protect us from dangerous or harmful situations. For instance, hearing a clap of thunder and then seeing the white streak of lightning across the sky tell us in an instant that the threat of a storm is near and to take cover for safety. The sour smell of expired milk warns us not to drink it. signal. The inner ear also contains semicircular canals, which transduce the movement of the head, impacting our balance. The Chemical Senses ● The senses of taste and smell are chemical senses. Both odors and tastes are how we experience chemical sensations in the environment that stimulate specific chemoreceptors. ● Humans can identify many different types of chemicals in the things we eat. These are our tastes. The basic tastes perceivable by humans are sweet, sour, bitter, salty and umami. Tastebuds on the tongue contain clusters of sensory cells, with each cell having a taste receptor for one of the five tastes. The transduction mechanism for each of the five tastes is unique. ● The olfactory epithelium is a large cluster of cells lining the nasal cavity. The olfactory epithelium contains olfactory receptor neurons. These neurons have dendrites that help airborne particles bind to olfactory receptors. When those molecules bind to their receptors, these cells transduce that event into a series of action potentials. This is how we smell things. Humans have approximately twelve million olfactory receptors to translate different scents. Most dogs have about one billion olfactory receptors. ● Somatosensation includes not just touch, but all sensations received from the skin and mucous membranes, including temperature, pain, pressure, and vibration. It also includes the vestibular sense of balance and proprioception, which is the sense of our body’s place in relation to its environment. ● Below the epidermis and dermis (the top layers of skin) is the subcutaneous layer. This layer contains the axons of the sensory neurons. These neurons have a variety of receptors to transduce a wide range of sensory inputs. ● The touch receptors or mechanoreceptors provide information to the brain about the sensations of the skin—including touch, pressure, and vibration. Mechanoreceptors are typically connected to large axons, which helps transmit tactile information to the brain quickly. ● The temperature receptors or thermoreceptors are divided into low- and high-threshold types. The lowthreshold receptors are activated by moderate temperatures, which are usually not painful and do not damage tissue. High-threshold receptors respond mainly to extreme temperatures, which are perceived as painful and can cause damage to tissue. ● Scientists studying pain at the tissue level refer to it as nociception. Pain is how neurons process a stimulus that causes injury, or tissue damage. The Motor System ● Planning and executing movement is a major role of our central and peripheral nervous systems. The type of movement dictates which brain regions will be involved in creating the movements. ● In some parts of the body, somatosensory input goes directly to motor neurons. This creates a reflex. This circuit produces a motor output without any communication with the brain. It is a type of involuntary movement. ● The basal ganglia are brain structures that regulate the body’s willingness to initiate movement. Damage to the basal ganglia leads to motor impairments like spastic twitches. Examples of damage to the basal ganglia can be seen in Parkinson’s disease and Huntington’s disease. ● The cerebellum is located at the back of the brain. Although the cerebellum is only about 10 percent of the brain’s volume, it contains over 50 percent of the total number of neurons in the brain. With all these neurons, the cerebellum plays a major role in the learning of new motor tasks and skills. 2023–2024 Science Student Exercise Book 13 Dallas ISD - Dallas, TX Somatosensory System EXERCISES CROSSWORD PUZZLE SCIENCE AN INTRODUCTION TO NEUROSCIENCE 2023-2024 Across Down 4. Very small bones of the middle ear 1. Creates the sense of balance and spatial orientation 5. The process of translating sensory stimuli ®into 2. T he targets of this system are the muscles The vision of the United States Academic Decathlon is to provide students the opportunity to excel academically through team competition. electrochemical signals themselves Toll Free: 866-511-USAD (8723) • Direct: 712-326-9589 • Fax: 712-366-3701 • Email: info@usad.org • Website: www.usad.org 6. Regulates a body’s willingness to induce movement 3. I ncludes all sensations received skin This material may not be reproduced or transmitted, in whole or in part, by any means, including but not limited to photocopy, print, electronic, or internet displayfrom (public orthe private sites) and or downloading, without prior written permission from USAD. Violators may be prosecuted. Copyright 2023 by United States Academic Decathlon . All rights reserved. 8. The sense of where our bodies are in space mucous membranes 9. The taste described as savory 7. Where the transduction of light occurs in the body 10. R esponsible for detecting odorant molecules in the air ® 2023–2024 Science Student Exercise Book 14 ® Dallas ISD - Dallas, TX DIRECTIONS: Complete the crossword puzzle below using terms you learned in section III of your resource guide. Good luck! SHORT-ANSWER QUESTIONS DIRECTIONS: Write one to three sentences to answer the following questions. 1. Explain what it means to transduce. Give one example of the way the sensory system transduces environmental signals. _________________________________________________________________________________ _________________________________________________________________________________ _________________________________________________________________________________ _________________________________________________________________________________ _________________________________________________________________________________ SCIENCE _________________________________________________________________________________ 3. Describe the difference between voluntary and involuntary movements and give an example of each. AN INTRODUCTION TO NEUROSCIENCE _________________________________________________________________________________ _________________________________________________________________________________ 2023-2024 _________________________________________________________________________________ 4. Describe what the taste of umami is and where it originated. _________________________________________________________________________________ The vision of the United States Academic Decathlon® is to provide students the opportunity to excel academically through team competition. Toll Free: 866-511-USAD (8723) • Direct: 712-326-9589 • Fax: 712-366-3701 • Email: info@usad.org • Website: www.usad.org _________________________________________________________________________________ This material may not be reproduced or transmitted, in whole or in part, by any means, including but not limited to photocopy, print, electronic, or internet display (public or private sites) or downloading, without prior written permission from USAD. Violators may be prosecuted. Copyright ® 2023 by United States Academic Decathlon®. All rights reserved. _________________________________________________________________________________ 2023–2024 Science Student Exercise Book 15 Dallas ISD - Dallas, TX 2. Describe somatosensation in one sentence. FILL IN THE BLANKS DIRECTIONS: Fill in the missing words with vocabulary you learned in section III of your resource guide. 1. As we interact with our environments, the ___________ systems bring information about the world into the brain and motor systems. 2. Somatosensation includes our ___________ sense of balance and position in space. 4. Sound itself is a series of pressure changes in the air and can vary in ___________ (which we experience as pitch or tone) and in ___________ (which we experience as loudness or volume) over time. SCIENCE 5. The eardrum’s movements change the pressure waves of the air into physical movements in the ______ ear. 6. Vision is the product of a complex visual system. The ability to see is made possible by ___________ neurons of the retina, inside the eye. AN INTRODUCTION TO NEUROSCIENCE 7. The basic tastes perceivable by humans are sweet, sour, ___________, salty, and ___________. 8. 2023-2024 Humans have approximately twelve million ___________. That’s impressive, but rabbits have about one hundred million, and most dogs have about one billion. The vision of the United States Academic Decathlon® is to provide students the opportunity to excel academically through team competition. Toll Free: 866-511-USAD (8723) • Direct: 712-326-9589 • Fax: 712-366-3701 • Email: info@usad.org • Website: www.usad.org This material may not be reproduced or transmitted, in whole or in part, by any means, including but not limited to photocopy, print, electronic, or internet display (public or private sites) or downloading, without prior written permission from USAD. Violators may be prosecuted. Copyright ® 2023 by United States Academic Decathlon®. All rights reserved. 2023–2024 Science Student Exercise Book 16 Dallas ISD - Dallas, TX 3. ___________ is our sense of the location and position of our bodies in relation to the world and the space we’re in. EITHER/OR DIRECTIONS: Read the sentences below and choose the word or words from the provided pair that correctly completes the thought. 1. The sense of smell can also be described as (olfaction / transduction). 2. The sense of taste is also called (gestation / gustation). 3. Light travels to the (photoreceptor / electromagnetic) neurons of the retina. 4. (Rods / Rails) and cones are two types of photoreceptor cells. 6. The area of the ear that transduces sound is the (inner ear / outer ear). SCIENCE 7. The area of the ear that transduces the movement of the head are the (semicircular canals / spherical canals). 8. Pain at the tissue level is called (nociception / proprioception). 9. When somatosensory input goes straight to the motor system, it creates a (synaptic / reflex) response. AN INTRODUCTION TO NEUROSCIENCE 10. The (cerebrum / cerebellum) is approximately 10 percent of the brain’s volume. 2023-2024 The vision of the United States Academic Decathlon® is to provide students the opportunity to excel academically through team competition. Toll Free: 866-511-USAD (8723) • Direct: 712-326-9589 • Fax: 712-366-3701 • Email: info@usad.org • Website: www.usad.org This material may not be reproduced or transmitted, in whole or in part, by any means, including but not limited to photocopy, print, electronic, or internet display (public or private sites) or downloading, without prior written permission from USAD. Violators may be prosecuted. Copyright ® 2023 by United States Academic Decathlon®. All rights reserved. 2023–2024 Science Student Exercise Book 17 Dallas ISD - Dallas, TX 5. The scientific word for ears is (proline / pinnae). Section IV Synaptic Plasticity and Memory OVERVIEW ● Neuroplasticity is our brain’s remarkable ability to continue to change and adapt throughout our lives. When we learn something new, we create connections between our neurons. ● Synaptic plasticity is change that occurs at synapses. These changes are connected to the brain’s capacity to learn and grow. ● Changes in synaptic strength based on experience are likely connected to encoding and storing memories. For that reason, synaptic plasticity is widely researched. Strengthening and Weakening Synapses ● It was once thought that as we become adults, the brain’s networks become fixed. It’s true the brain becomes less plastic as we grow older, but it never stops changing and adjusting entirely. The brain is always acquiring new information from our experiences. ● Storing information in our brains is referred to as memory. Learning and memory both rely on plastic changes in our neural networks. ● Scientists can use electrophysiological recordings to measure whether the strength of a synapse changes as a result of experience. ● Electrodes can be placed in animals doing tasks like mazes. Scientists can observe in real time how the synaptic strength in a circuit may change or grow during these tasks. Memory Systems ● Our brain’s memory system focuses on important memories. These are often connected to experiences that yielded an emotional response or in response to situations or thoughts that regularly occur. The hippocampus plays a key role in picking which memories to keep and store away. ● The hippocampus receives connections from all the brain’s primary sensory areas as well as its neighboring areas. It helps to choose where to store the memories. For instance, a memory connected to a song is stored close to the auditory cortex. ● Short-term memory means exactly what it sounds like. Not everything we experience needs to be stored in our brains long-term. Instead of holding onto something mundane for years—like what we ate for breakfast yesterday—this memory will likely disappear after we stop focusing attention on it. ● Long-term memory is divided into the subgroups of explicit memory and implicit memory. ♦ Explicit memory is the kind that a person can recall consciously. Explicit memories can be semantic memories. These are facts that we may remember forever—like lines from a nursery rhyme learned in school. Explicit memories can also be episodic memories. These are related to 2023–2024 Science Student Exercise Book 18 Dallas ISD - Dallas, TX Brain plasticity (or neuroplasticity) is an unusual term for a cool thing that happens in our brains when we learn things. Neuroplasticity doesn’t have anything to do with plastic, the hard and rigid material. The word plasticity refers to the ability to be shaped and molded. particularly unforgettable “episodes” from our lives—for instance, a first kiss. Implicit memories take a lot of effort to learn and are not recalled consciously. They are automatic. Once these memories are in our brains, they’re likely going to be stored there forever. For instance, learning to type on a keyboard exhibits implicit memory. This type of implicit memory is a procedural memory. This is a learned motor skill. ♦ Explicit memories are pulled together by the hippocampus and “packaged” up for long-term storage. Implicit memories don’t need the hippocampus to be stored. Dallas ISD - Dallas, TX ♦ 2023–2024 Science Student Exercise Book 19 EXERCISES MULTIPLE-CHOICE QUIZ DIRECTIONS: Select the option that best answers the question or completes the statement. 1. Plasticity is our brain’s ability to a. retain short-term memories b. adapt and change c. prune trivial information d. harden as it ages e. retain long-term memories 3. A memory that we remember long-term but that isn’t connected to an emotional response is called a(n) a. episodic memory b. factual memory c. intelligent memory d. non-emotive memory e. semantic memory SCIENCE 4. An explicit memory is a A N and I N Texperiences RODUCTION a. conscious recollection of factual information b. type of short-term memory c. memory that is subconscious and difficult to recollect d. vivid memory e. formative memory from early childhood TO NEUROSCIENCE 2023-2024 5. An implicit memory is a(n) a. type of short-term memory b. unconscious and automatic memory c. formative memory from early childhood ® d. vision memory that’s to an emotional response The of the United Statestied Academic Decathlon is to provide students the opportunity to excel academically through team competition. Toll Free: 866-511-USAD (8723) • Direct: 712-326-9589 • Fax: 712-366-3701 • Email: info@usad.org • Website: www.usad.org e. conscious recollection of an experience This material may not be reproduced or transmitted, in whole or in part, by any means, including but not limited to photocopy, print, electronic, or internet display (public or private sites) or downloading, without prior written permission from USAD. Violators may be prosecuted. Copyright ® 2023 by United States Academic Decathlon®. All rights reserved. 6. Which of the following packages up long-term memories for storage in our brains? a. synapses b. neural networks c. hippocampus d. neuroplastic cells e. amygdala 2023–2024 Science Student Exercise Book 20 Dallas ISD - Dallas, TX 2. When we learn new things, we create new connections between a. neurons b. our brain hemispheres c. the spinal cord and our brain d. ossicles e. procedural memories 7. The more we engage _________, the stronger the connections between them become. a. reflexes b. the auditory reflex c. semantic memories d. plasticity e. synapses Dallas ISD - Dallas, TX 8. A procedural memory is a(n) a. learned motor skill b. short-term memory c. long-term memory that is solely based on emotion d. episodic memory of a one-time event e. memory that is difficult to recall 2023–2024 Science Student Exercise Book 21 SHORT-ANSWER QUIZ DIRECTIONS: Respond briefly to each of the following items to test your understanding of some of the concepts introduced in this section. 1. Describe the concept of neuroplasticity and why it is important. _________________________________________________________________________________ _________________________________________________________________________________ _________________________________________________________________________________ 2. Explain the difference between explicit memory and implicit memory and give one example of each. _________________________________________________________________________________ _________________________________________________________________________________ SCIENCE 3. Give three different examples of semantic memory. a) Example one: ________________________________________________________________ b) Example two: _______________________________________________________________ AN INTRODUCTION TO NEUROSCIENCE c) Example three: ______________________________________________________________ 4. The sensory cortex can adapt to changes in sensory input. Describe one of the examples of cortical changes discussed in section IV. 2023-2024 _________________________________________________________________________________ _________________________________________________________________________________ _________________________________________________________________________________ The vision of the United States Academic Decathlon® is to provide students the opportunity to excel academically through team competition. Toll Free: 866-511-USAD (8723) • Direct: 712-326-9589 • Fax: 712-366-3701 • Email: info@usad.org • Website: www.usad.org This material may not be reproduced or transmitted, in whole or in part, by any means, including but not limited to photocopy, print, electronic, or internet display (public or private sites) or downloading, without prior written permission from USAD. Violators may be prosecuted. Copyright ® 2023 by United States Academic Decathlon®. All rights reserved. 2023–2024 Science Student Exercise Book 22 Dallas ISD - Dallas, TX _________________________________________________________________________________ Section V Technology and Neuroscience OVERVIEW What we know about neuroscience today is thanks to scientific and technological developments. Technology is evolving to give scientists and doctors new ways to study the brain and nervous system. Technological advancements have progressed more rapidly in the past two decades than ever before. New Methods of Perturbing the Brain ● Transcranial direct current stimulation (tDCS) uses one positive and one negative electrode to run current through the brain, increasing or decreasing activity in particular regions. ● Transcranial magnetic stimulation (TMS) creates an electric field within the cortex. This changes the normal electrical activity and confirms findings from lesion studies and imaging studies. For example, studies that record brain activity might show a certain task utilizes a certain brain region. Scientists can use TMS to temporarily “turn off” that brain region. They can then see if the subject can still perform the task properly. New Methods of Recording from the Brain Techniques and tools for recording brain activity have progressed as well. ● Extracellular recording uses an electrode to measure the membrane potentials from a population of cells from just outside those cells. This can be done in animals under local anesthesia, so that extracellular recordings can be gathered from these animals as they perform natural behavior or learned tasks, like mazes. This can tell scientists more about how neurons impact behavior. ● Modern EEG (electroencephalogram) uses electrodes attached to the surface of the scalp to record the electrical impulses created by large populations of neurons right through the skull. An EEG can show differences in individuals who have conditions such as epilepsy. EEG is also routinely used in studying sleep. ● Magnetic resonance imaging (MRI) uses a strong magnetic field to capture detailed images of the inside of the body. MRIs can also show where oxygenated blood flows over time. This can show which regions of the brain are more active at certain times. An MRI can be used to see changes in blood flow in the brain in almost real time in order to see where neural activity likely is in the brain. This allows us to create activation maps of parts of the brain that may be involved in a particular task. This is a process called functional MRI (fMRI). ● A brain−machine interface or BMI (sometimes also called a brain−computer interface) is a system 2023–2024 Science Student Exercise Book 23 Dallas ISD - Dallas, TX Many aspects of the nervous system have been studied previously by perturbing the brain. This means changing or altering something in it and then seeing what changes occur in the resulting behavior. This method uses small metal discs called electrodes to gather data about the cells of the brain. Previously, the only way to do this required drilling a hole in the skull. Given that this was painful and dangerous, scientists looked for noninvasive methods to study the brain, such as these: that allows a person to control a device or machine using only their thoughts. It usually consists of a device that records neural activity from a particular brain region. Then, a computer system translates that activity into commands that can be used to control an external device. One day, this brain-machine technology may allow people with limited mobility more freedom to do physical tasks. A New Type of Neuroscience Dallas ISD - Dallas, TX The use of computer algorithms has allowed scientists to create models and simulations of neurons to better understand how they may work under different circumstances. This new branch of neuroscience is called computational neuroscience, and it has the potential to help scientists and clinicians better assess data via powerful computers. In doing so, they will better understand disorders and diseases of the brain and treat them more effectively. 2023–2024 Science Student Exercise Book 24 EXERCISES TRUTH OR REPAIR DIRECTIONS: Read each of the following statements and determine whether it is true or false. If the sentence is false, correct the statement in the space provided. 1. In 2013, then U.S. President Obama outlined the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. _________________________________________________________________________________ 2. The Human Neuroinnovation Project is creating the world’s largest map of neural circuit structure and function. _________________________________________________________________________________ 4. Paul Broca studied a patient with memory impairment and was able to map the function to the corresponding part of the brain. _________________________________________________________________________________ SCIENCE 5. Lesion studies require implanting an electrode in the brain. _________________________________________________________________________________ N I Nwith T R external O D U C Telectrodes, I O N T O such N E as U Rwith O S an C IEEG. ENCE 6. It is possible to record neural activity through theA skull _________________________________________________________________________________ 7. Transcranial direct current stimulation is used in clinical settings and is approved by the FDA to treat depression. _________________________________________________________________________________ 2023-2024 8. Magnetic resonance imaging (MRI) uses a strong magnetic field to produce detailed images of the inside of the body or other organism. _________________________________________________________________________________ ® The vision of the United States Academic Decathlon is to provide students the opportunity to excel academically through team competition. Toll Free: 866-511-USAD (8723) • Direct: 712-326-9589 • Fax: 712-366-3701 • Email: info@usad.org • Website: www.usad.org may not be reproduced or transmitted, allows in whole or inapart, by any means, but not to photocopy, print, electronic,using or internetonly display (public sites) 9. This A material brain−machine interface person to including control a limited device or machine theiror private thoughts. or downloading, without prior written permission from USAD. Violators may be prosecuted. Copyright 2023 by United States Academic Decathlon . All rights reserved. _________________________________________________________________________________ ® 2023–2024 Science Student Exercise Book 25 ® Dallas ISD - Dallas, TX 3. Two mechanisms for studying the nervous system include perturbing the brain and recording from the brain. _________________________________________________________________________________ FILL IN THE BLANKS DIRECTIONS: Fill in the missing words using what you learned in section V. Some words may be used more than once. ________________ the brain means to purposely change or alter something in the brain, with the objective of seeing what behavioral changes occur. Scientists used to create ________________ on animals’ brains to study them. One method of perturbing the brain uses ________________ to add current to the brain. These can stimulate certain ________________ and gather data about what the cells in the brain are doing. ________________ can also be used to record information from the brain, both intracellularly (inside a cell) Any type of neuroscience that uses mathematical models, computer simulations, or theoretical analysis to understand the ________________ may be referred to as ________________ neuroscience. SCIENCE Using computer ________________ or simulator programs to model the behavior of ________________ has a wide range of applications. For example, the fast-growing field of ________________ makes use of modeling and machine learning to supplement patients’ subjective reports of their emotions and physical states during diagnosis. AN INTRODUCTION TO NEUROSCIENCE 2023-2024 The vision of the United States Academic Decathlon® is to provide students the opportunity to excel academically through team competition. Toll Free: 866-511-USAD (8723) • Direct: 712-326-9589 • Fax: 712-366-3701 • Email: info@usad.org • Website: www.usad.org This material may not be reproduced or transmitted, in whole or in part, by any means, including but not limited to photocopy, print, electronic, or internet display (public or private sites) or downloading, without prior written permission from USAD. Violators may be prosecuted. Copyright ® 2023 by United States Academic Decathlon®. All rights reserved. 2023–2024 Science Student Exercise Book 26 Dallas ISD - Dallas, TX and ________________ (outside a cell). Answer Keys SECTION II ANSWER KEY Truth or Repair Crossword Puzzle 1. TRUE 2. FALSE; The largest part of the brain is called the cerebellum cerebrum. 3. FALSE; The brain and brainstem spinal cord make up the central nervous system. 4. TRUE 5. TRUE 6. FALSE; The area where one neuron communicates with another is called an axon a synapse. 7. TRUE 8. FALSE; Microglia Astrocytes help balance the chemical makeup of the fluid in between cells of the nervous system. 9. FALSE; The brainstem is located at the back bottom of the brain. 10. FALSE; The cerebrum contains two equal parts, the top left, and the bottom right hemispheres. Across 4. Postsynaptic neuron 5. Axon 7. Action potential 8. Neurotransmitter 9. Cytosol 10. Ion Vocab Match-Up 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. G J H C A B I F D E Down 1. Passive transport 2. Presynaptic neuron 3. Neuronal membrane 6. Active transport Fill in the Blanks Neurons can send electrical signals very long distances across the body. These signals are called action potentials. They are key to communication between nerves, the brain, and the body. Action potentials travel down the neuron’s long axon very quickly. Once the action potential reaches the bottom, synaptic transmission occurs—this is when neurons transfer signals. The neuron releasing the signal is called the presynaptic neuron. The neuron receiving the signal is called the postsynaptic neuron. To send a signal to the next neuron, most cells translate the action potential from an electrical signal into a chemical signal that moves across the space between cells. The chemicals involved are called neurotransmitters, which are various in kind. 2023–2024 Science Student Exercise Book 27 Dallas ISD - Dallas, TX SECTION I ANSWER KEY SECTION III ANSWER KEY Naturally, your responses may vary somewhat from the answers given in this key, but they should be similar. 1. An action potential is the electrical potential of a cell when the cell is active and firing. It is also referred to as a spike or a nerve impulse. An action potential is the method neurons use to encode and send signals over long distances. 2. Sensory neurons can be triggered by exposure to light or darkness or to something hot to the touch. They can be triggered by sound waves from a clap of thunder or any other environmental stimuli that results in a sensation. 3. When ions are in a higher concentration in one part of a cell, they will move or disperse to other areas to make a more even concentration of ions throughout the cell. 4. When a neuron is capable of sending an electrical signal, but it is not doing so, it is at rest. The resting membrane potential is the electrical charge of the neuron in this state. 5. It can help them understand what sort of drugs to create or prescribe to people to help with conditions or imbalances in the brain. Crossword Puzzle Across 4. Ossicles 5. Sensory transduction 6. Basal ganglia 8. Proprioception 9. Umami 10. Olfactory receptors Down 1. Vestibular system 2. Motor system 3. Somatosensation 7. Retina Short-Answer Questions Naturally, your responses may vary somewhat from the answers given in this key, but they should be similar. 1. To transduce means to convert. The sensory system transduces (converts) environmental signals into electrochemical signals, which travel to the brain to create a sensation. An example from the visual system is how light is transduced into electrochemical signals in the retina which, once processed in the brain, allows us to see. 2. Possible sentences include these: (1) Somatosensation includes not just touch, but also the sensory experience of temperature, pain, pressure, and vibration; (2) Somatosensation includes all sensations received from the skin and mucous membranes. 3. Voluntary movements are movements we consciously think about and purposefully do, such as sitting upright to get out of bed. Involuntary movements are things our bodies do without conscious thought or effort, such as breathing. 4. Umami is the taste of something savory. The idea of umami originated in Japan. 2023–2024 Science Student Exercise Book 28 Dallas ISD - Dallas, TX Short-Answer Questions SECTION IV ANSWER KEY Fill in the Blanks Either/Or 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. olfaction gustation photoreceptor rods pinnae inner ear semicircular canals nociception reflex cerebellum Multiple-Choice Quiz 1. 2. 3. 4. 5. 6. 7. 8. b a e a b c e a Short-Answer Quiz Naturally, your responses may vary somewhat from the answers given in this key, but they should be similar. 1. Neuroplasticity is our brain’s ability to continue to change and adapt. It is important because we can continue to grow and adjust to experiences throughout our lives. 2. Implicit memories are recalled unconsciously, whereas explicit memories are things we consciously remember and recall. Remembering how to type on a computer or ride a bike are examples of implicit memories. Remembering how to recite the fifty states of the U.S. in alphabetical order or remembering when you scored the winning goal in a soccer game are explicit memories. 3. Examples may vary, but they must be examples of remembered facts that don’t have context or emotions attached, such as remembering a nursery rhyme, the capital city of a state, or the names of colors. 4. The three examples discussed in section IV are these: a) Monocular deprivation (depriving one eye of stimulation); scientists discovered that even a short period of deprivation during a critical period of early life can change the structure of the synapses and dendrites in the cortex permanently. b) Rodent barrel fields; scientists discovered that if a row of whiskers is plucked from a newly born rat, the corresponding whisker barrels (the areas in the somatosensory cortex that respond to those whiskers) will never form. Instead, an expansion of the representation for neighboring whiskers is seen in the cortex 2023–2024 Science Student Exercise Book 29 Dallas ISD - Dallas, TX 1. As we interact with our environments, the sensory systems bring information about the world into the brain and motor systems. 2. Somatosensation includes our vestibular sense of balance and position in space. 3. This body functionality also includes proprioception, which is the location and position of our bodies in relation to the world and space we’re in. 4. Sound itself is a series of pressure changes in the air and can vary in frequency (which we experience as pitch or tone) and in intensity (which we experience as loudness or volume) over time. 5. The eardrum’s movements change the pressure waves of the air into physical movements in the middle ear. 6. Vision is the product of a complex visual system. The ability to see is made possible by photoreceptor neurons of the retina, inside the eye. 7. The basic tastes perceivable by humans are sweet, sour, bitter, salty, and umami. 8. Humans have approximately twelve million olfactory receptors. That’s impressive, but rabbits have about one hundred million, and most dogs have about one billion. SECTION V ANSWER KEY Truth or Repair 1. TRUE 2. FALSE; The Human Neuroinnovation Connectome Project is creating the world’s largest map of synapses neural circuit structure and function. 3. TRUE 4. FALSE; Paul Broca studied a patient with memory speech impairment and was able to map the function to the corresponding part of the brain. 5. FALSE; Lesion studies Electrical brain stimulation requires implanting an electrode in the brain. 6. TRUE 7. FALSE; Transcranial direct current stimulation Transcranial magnetic stimulation (TMS) is used in clinical settings and is approved by the FDA to treat depression. 8. TRUE 9. TRUE Fill in the Blanks Perturbing the brain means to purposely change or alter something in the brain, with the objective of seeing what behavioral changes occur. Scientists used to create lesions on animals’ brains to study them. One method of perturbing the brain uses electrodes to add current to the brain. These can stimulate certain neurons and gather data about what the cells in the brain are doing. Electrodes can also be used to record information from the brain, both intracellularly (inside a cell) and extracellularly (outside a cell). Any type of neuroscience that uses mathematical models, computer simulations, or theoretical analysis to understand the nervous system may be referred to as computational neuroscience. Using computer algorithms or simulator programs to model the behavior of neurons has a wide range of applications. For example, the fast-growing field of computational psychiatry makes use of modeling and machine learning to supplement patients’ subjective reports of their emotions and physical states during diagnosis. 2023–2024 Science Student Exercise Book 30 Dallas ISD - Dallas, TX permanently. c) Phantom limb syndrome; when a patient has lost part of their body—such as a limb—in an accident, they may still perceive sensations coming from the part of the body that is no longer there. This is due to cortical changes wherein the missing limb is taken over in the brain by representations elsewhere.